| Category | Name | IntersectionWithQuery | PValue | GenesInTerm | GenesInQuery | GenesInTermInQuery | ID |
|---|---|---|---|---|---|---|---|
| GeneOntologyMolecularFunction | L-glutamate uniporter activity | 1.29e-05 | 3 | 42 | 2 | GO:0140788 | |
| GeneOntologyMolecularFunction | membrane potential driven uniporter activity | 4.30e-05 | 5 | 42 | 2 | GO:0022810 | |
| GeneOntologyMolecularFunction | uniporter activity | 1.92e-04 | 10 | 42 | 2 | GO:0015292 | |
| GeneOntologyMolecularFunction | sodium:phosphate symporter activity | 2.81e-04 | 12 | 42 | 2 | GO:0005436 | |
| GeneOntologyMolecularFunction | L-glutamate transmembrane transporter activity | 4.46e-04 | 15 | 42 | 2 | GO:0005313 | |
| GeneOntologyMolecularFunction | acidic amino acid transmembrane transporter activity | 8.01e-04 | 20 | 42 | 2 | GO:0015172 | |
| GeneOntologyMolecularFunction | neurotransmitter transmembrane transporter activity | 8.84e-04 | 21 | 42 | 2 | GO:0005326 | |
| GeneOntologyMolecularFunction | phosphate transmembrane transporter activity | 1.16e-03 | 24 | 42 | 2 | GO:0005315 | |
| GeneOntologyMolecularFunction | cysteine-type endopeptidase inhibitor activity involved in apoptotic process | 1.16e-03 | 24 | 42 | 2 | GO:0043027 | |
| GeneOntologyMolecularFunction | protein serine/threonine kinase binding | 1.16e-03 | 24 | 42 | 2 | GO:0120283 | |
| GeneOntologyBiologicalProcess | regulation of apoptosis involved in tissue homeostasis | 1.27e-05 | 3 | 43 | 2 | GO:0060785 | |
| GeneOntologyCellularComponent | pericellular basket | 1.24e-05 | 3 | 43 | 2 | GO:1990030 | |
| Domain | BIR | 1.31e-04 | 8 | 41 | 2 | SM00238 | |
| Domain | BIR_REPEAT_2 | 1.31e-04 | 8 | 41 | 2 | PS50143 | |
| Domain | - | 1.31e-04 | 8 | 41 | 2 | 1.10.1170.10 | |
| Domain | BIR_rpt | 1.31e-04 | 8 | 41 | 2 | IPR001370 | |
| Domain | BIR_REPEAT_1 | 1.31e-04 | 8 | 41 | 2 | PS01282 | |
| Domain | BIR | 1.31e-04 | 8 | 41 | 2 | PF00653 | |
| Domain | PH_dom-spectrin-type | 1.68e-04 | 9 | 41 | 2 | IPR001605 | |
| Domain | VWC | 1.71e-03 | 28 | 41 | 2 | PF00093 | |
| Domain | VWFC_1 | 2.83e-03 | 36 | 41 | 2 | PS01208 | |
| Domain | VWC | 3.14e-03 | 38 | 41 | 2 | SM00214 | |
| Domain | VWFC_2 | 3.14e-03 | 38 | 41 | 2 | PS50184 | |
| Domain | PH | 3.16e-03 | 278 | 41 | 4 | SM00233 | |
| Domain | PH_DOMAIN | 3.20e-03 | 279 | 41 | 4 | PS50003 | |
| Domain | PH_domain | 3.24e-03 | 280 | 41 | 4 | IPR001849 | |
| Domain | VWF_dom | 3.83e-03 | 42 | 41 | 2 | IPR001007 | |
| Domain | CH | 8.96e-03 | 65 | 41 | 2 | SM00033 | |
| Domain | CH | 1.03e-02 | 70 | 41 | 2 | PF00307 | |
| Domain | HEAT_REPEAT | 1.03e-02 | 70 | 41 | 2 | PS50077 | |
| Domain | - | 1.04e-02 | 391 | 41 | 4 | 2.30.29.30 | |
| Pathway | REACTOME_SMAC_XIAP_REGULATED_APOPTOTIC_RESPONSE | 7.92e-05 | 6 | 33 | 2 | MM14489 | |
| Pathway | REACTOME_ACTIVATION_OF_CASPASES_THROUGH_APOPTOSOME_MEDIATED_CLEAVAGE | 1.11e-04 | 7 | 33 | 2 | MM14486 | |
| Pathway | REACTOME_REGULATION_OF_PTEN_LOCALIZATION | 2.36e-04 | 10 | 33 | 2 | MM15539 | |
| Pathway | REACTOME_FORMATION_OF_APOPTOSOME | 2.36e-04 | 10 | 33 | 2 | MM14485 | |
| Pathway | REACTOME_ORGANIC_ANION_TRANSPORTERS | 3.46e-04 | 12 | 33 | 2 | M27350 | |
| Pathway | REACTOME_ORGANIC_ANION_TRANSPORTERS | 3.46e-04 | 12 | 33 | 2 | MM15087 | |
| Pathway | REACTOME_CYTOCHROME_C_MEDIATED_APOPTOTIC_RESPONSE | 3.46e-04 | 12 | 33 | 2 | MM14487 | |
| Pathway | BIOCARTA_BCELLSURVIVAL_PATHWAY | 7.07e-04 | 17 | 33 | 2 | MM1353 | |
| Pathway | REACTOME_APOPTOTIC_FACTOR_MEDIATED_RESPONSE | 7.07e-04 | 17 | 33 | 2 | MM14490 | |
| Pubmed | Over-expression of X-linked inhibitor of apoptosis protein slows presbycusis in C57BL/6J mice. | 1.64e-06 | 2 | 45 | 2 | 18755525 | |
| Pubmed | Attenuation of MPTP-induced neurotoxicity and behavioural impairment in NSE-XIAP transgenic mice. | 1.64e-06 | 2 | 45 | 2 | 12667469 | |
| Pubmed | 1.64e-06 | 2 | 45 | 2 | 36769152 | ||
| Pubmed | X-linked inhibitor of apoptosis deficiency in the TRAMP mouse prostate cancer model. | 1.64e-06 | 2 | 45 | 2 | 18259199 | |
| Pubmed | XIAP regulates intracellular ROS by enhancing antioxidant gene expression. | 1.64e-06 | 2 | 45 | 2 | 18692482 | |
| Pubmed | 1.64e-06 | 2 | 45 | 2 | 20427267 | ||
| Pubmed | 1.64e-06 | 2 | 45 | 2 | 15888033 | ||
| Pubmed | 1.64e-06 | 2 | 45 | 2 | 31438981 | ||
| Pubmed | 1.64e-06 | 2 | 45 | 2 | 12812761 | ||
| Pubmed | 1.64e-06 | 2 | 45 | 2 | 28300832 | ||
| Pubmed | 1.64e-06 | 2 | 45 | 2 | 29605544 | ||
| Pubmed | 1.64e-06 | 2 | 45 | 2 | 29250796 | ||
| Pubmed | 1.64e-06 | 2 | 45 | 2 | 9205126 | ||
| Pubmed | Overexpression of XIAP inhibits cisplatin-induced hair cell loss. | 1.64e-06 | 2 | 45 | 2 | 35026350 | |
| Pubmed | 1.64e-06 | 2 | 45 | 2 | 31841118 | ||
| Pubmed | 1.64e-06 | 2 | 45 | 2 | 18687476 | ||
| Pubmed | 1.64e-06 | 2 | 45 | 2 | 11597143 | ||
| Pubmed | XIAP regulates cytosol-specific innate immunity to Listeria infection. | 1.64e-06 | 2 | 45 | 2 | 18769721 | |
| Pubmed | 1.64e-06 | 2 | 45 | 2 | 21099289 | ||
| Pubmed | 1.64e-06 | 2 | 45 | 2 | 19570023 | ||
| Pubmed | 1.64e-06 | 2 | 45 | 2 | 16115895 | ||
| Pubmed | XIAP deficiency in hematopoietic recipient cells drives donor T-cell activation and GvHD in mice. | 1.64e-06 | 2 | 45 | 2 | 30585320 | |
| Pubmed | 1.64e-06 | 2 | 45 | 2 | 16154537 | ||
| Pubmed | Eliminating encephalitogenic T cells without undermining protective immunity. | 1.64e-06 | 2 | 45 | 2 | 24277699 | |
| Pubmed | 1.64e-06 | 2 | 45 | 2 | 22065417 | ||
| Pubmed | XIAP-deficiency leads to delayed lobuloalveolar development in the mammary gland. | 1.64e-06 | 2 | 45 | 2 | 15540113 | |
| Pubmed | Regulation of the Hippocampal Network by VGLUT3-Positive CCK- GABAergic Basket Cells. | 1.64e-06 | 2 | 45 | 2 | 28559797 | |
| Pubmed | 1.64e-06 | 2 | 45 | 2 | 12042762 | ||
| Pubmed | Analysis of inhibitor of apoptosis protein family expression during mammary gland development. | 1.64e-06 | 2 | 45 | 2 | 20584313 | |
| Pubmed | XIAP inhibits gentamicin-induced hair cell damage and ototoxicity through the caspase-3/9 pathway. | 1.64e-06 | 2 | 45 | 2 | 33713642 | |
| Pubmed | Inability to resolve specific infection generates innate immunodeficiency syndrome in Xiap-/- mice. | 1.64e-06 | 2 | 45 | 2 | 25190756 | |
| Pubmed | 1.64e-06 | 2 | 45 | 2 | 11313486 | ||
| Pubmed | 1.64e-06 | 2 | 45 | 2 | 34025452 | ||
| Pubmed | X-linked inhibitor of apoptosis regulates T cell effector function. | 1.64e-06 | 2 | 45 | 2 | 18025200 | |
| Pubmed | 1.64e-06 | 2 | 45 | 2 | 18055022 | ||
| Pubmed | Identification of an Xiap-like pseudogene on mouse chromosome 7. | 1.64e-06 | 2 | 45 | 2 | 19956646 | |
| Pubmed | 1.64e-06 | 2 | 45 | 2 | 34739342 | ||
| Pubmed | Skeletal muscle differentiation evokes endogenous XIAP to restrict the apoptotic pathway. | 1.64e-06 | 2 | 45 | 2 | 19333375 | |
| Pubmed | IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells. | 1.64e-06 | 2 | 45 | 2 | 29386580 | |
| Pubmed | S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease. | 4.91e-06 | 3 | 45 | 2 | 19273858 | |
| Pubmed | Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family. | 4.91e-06 | 3 | 45 | 2 | 11390657 | |
| Pubmed | 4.91e-06 | 3 | 45 | 2 | 38351372 | ||
| Pubmed | The Sept4 septin locus is required for sperm terminal differentiation in mice. | 4.91e-06 | 3 | 45 | 2 | 15737931 | |
| Pubmed | Median raphe controls acquisition of negative experience in the mouse. | 4.91e-06 | 3 | 45 | 2 | 31780530 | |
| Pubmed | XIAP decreases caspase-12 cleavage and calpain activity in spinal cord of ALS transgenic mice. | 4.91e-06 | 3 | 45 | 2 | 16566922 | |
| Pubmed | Quercetin ameliorates XIAP deficiency-associated hyperinflammation. | 4.91e-06 | 3 | 45 | 2 | 35687753 | |
| Pubmed | 4.91e-06 | 3 | 45 | 2 | 15258565 | ||
| Pubmed | 4.91e-06 | 3 | 45 | 2 | 25782435 | ||
| Pubmed | 4.91e-06 | 3 | 45 | 2 | 23928917 | ||
| Pubmed | Involvement of the Edar signaling in the control of hair follicle involution (catagen). | 4.91e-06 | 3 | 45 | 2 | 17148670 | |
| Pubmed | Vesicular Glutamate Transporters (SLCA17 A6, 7, 8) Control Synaptic Phosphate Levels. | 4.91e-06 | 3 | 45 | 2 | 33440152 | |
| Pubmed | Lack of evidence for vesicular glutamate transporter expression in mouse astrocytes. | 4.91e-06 | 3 | 45 | 2 | 23467360 | |
| Pubmed | Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size. | 4.91e-06 | 3 | 45 | 2 | 29775577 | |
| Pubmed | Loss of XIAP facilitates switch to TNFα-induced necroptosis in mouse neutrophils. | 4.91e-06 | 3 | 45 | 2 | 27735938 | |
| Pubmed | MiR-96 promotes myocardial infarction-induced apoptosis by targeting XIAP. | 4.91e-06 | 3 | 45 | 2 | 33752931 | |
| Pubmed | Interaction between XIAP and Smac/DIABLO in the mouse brain after transient focal cerebral ischemia. | 4.91e-06 | 3 | 45 | 2 | 12973017 | |
| Pubmed | 4.91e-06 | 3 | 45 | 2 | 24395041 | ||
| Pubmed | The X-linked inhibitor of apoptosis regulates long-term depression and learning rate. | 4.91e-06 | 3 | 45 | 2 | 27189977 | |
| Pubmed | 4.91e-06 | 3 | 45 | 2 | 19595300 | ||
| Pubmed | 4.91e-06 | 3 | 45 | 2 | 26825770 | ||
| Pubmed | 4.91e-06 | 3 | 45 | 2 | 24335231 | ||
| Pubmed | Interaction of checkpoint kinase 1 and the X-linked inhibitor of apoptosis during mitosis. | 4.91e-06 | 3 | 45 | 2 | 14759516 | |
| Pubmed | 4.91e-06 | 3 | 45 | 2 | 24422988 | ||
| Pubmed | Sept4/ARTS is required for stem cell apoptosis and tumor suppression. | 4.91e-06 | 3 | 45 | 2 | 20952537 | |
| Pubmed | Docking and homology modeling explain inhibition of the human vesicular glutamate transporters. | 4.91e-06 | 3 | 45 | 2 | 17660252 | |
| Pubmed | 4.91e-06 | 3 | 45 | 2 | 21709246 | ||
| Pubmed | Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes. | 4.91e-06 | 3 | 45 | 2 | 29743550 | |
| Pubmed | 4.91e-06 | 3 | 45 | 2 | 20129247 | ||
| Pubmed | 4.91e-06 | 3 | 45 | 2 | 12395105 | ||
| Pubmed | FAIM-L regulation of XIAP degradation modulates Synaptic Long-Term Depression and Axon Degeneration. | 4.91e-06 | 3 | 45 | 2 | 27767058 | |
| Pubmed | 9.81e-06 | 4 | 45 | 2 | 29899110 | ||
| Pubmed | Inhibitor of Apoptosis Proteins (IAPs) Limit RIPK1-Mediated Skin Inflammation. | 9.81e-06 | 4 | 45 | 2 | 28647349 | |
| Pubmed | 9.81e-06 | 4 | 45 | 2 | 16543147 | ||
| Pubmed | 9.81e-06 | 4 | 45 | 2 | 21533085 | ||
| Pubmed | 9.81e-06 | 4 | 45 | 2 | 38278147 | ||
| Pubmed | 9.81e-06 | 4 | 45 | 2 | 19473982 | ||
| Pubmed | Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo. | 9.81e-06 | 4 | 45 | 2 | 15798218 | |
| Pubmed | 9.81e-06 | 4 | 45 | 2 | 9990045 | ||
| Pubmed | Regulation of the copper chaperone CCS by XIAP-mediated ubiquitination. | 9.81e-06 | 4 | 45 | 2 | 20154138 | |
| Pubmed | Sept4/ARTS regulates stem cell apoptosis and skin regeneration. | 9.81e-06 | 4 | 45 | 2 | 23788729 | |
| Pubmed | 9.81e-06 | 4 | 45 | 2 | 31756561 | ||
| Pubmed | 9.81e-06 | 4 | 45 | 2 | 23954782 | ||
| Pubmed | X-Linked inhibitor of apoptosis protein is involved in mutant SOD1-mediated neuronal degeneration. | 9.81e-06 | 4 | 45 | 2 | 12153481 | |
| Pubmed | 9.81e-06 | 4 | 45 | 2 | 18761086 | ||
| Pubmed | 9.81e-06 | 4 | 45 | 2 | 15207275 | ||
| Pubmed | Unique anti-apoptotic activity of EAAC1 in injured motor neurons. | 9.81e-06 | 4 | 45 | 2 | 16858406 | |
| Pubmed | 9.81e-06 | 4 | 45 | 2 | 19897582 | ||
| Pubmed | The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms. | 9.81e-06 | 4 | 45 | 2 | 28656888 | |
| Pubmed | The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif. | 9.81e-06 | 4 | 45 | 2 | 11602612 | |
| Pubmed | 9.81e-06 | 4 | 45 | 2 | 18684108 | ||
| Pubmed | 9.81e-06 | 4 | 45 | 2 | 32060280 | ||
| Pubmed | IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα. | 1.63e-05 | 5 | 45 | 2 | 27129149 | |
| Pubmed | XIAP activity dictates Apaf-1 dependency for caspase 9 activation. | 1.63e-05 | 5 | 45 | 2 | 17562856 | |
| Pubmed | 1.63e-05 | 5 | 45 | 2 | 21695558 | ||
| Pubmed | 1.63e-05 | 5 | 45 | 2 | 11355574 | ||
| Pubmed | XIAP restricts TNF- and RIP3-dependent cell death and inflammasome activation. | 1.63e-05 | 5 | 45 | 2 | 24882010 | |
| Pubmed | 1.63e-05 | 5 | 45 | 2 | 33845129 | ||
| Pubmed | Protocol to map multi-transmitter neurons in the mouse brain using intersectional strategy. | 1.63e-05 | 5 | 45 | 2 | 36595933 | |
| Pubmed | XIAP discriminates between type I and type II FAS-induced apoptosis. | 1.63e-05 | 5 | 45 | 2 | 19626005 | |
| Pubmed | 1.63e-05 | 5 | 45 | 2 | 8643514 | ||
| Cytoband | 1q25 | 2.88e-04 | 26 | 44 | 2 | 1q25 | |
| Cytoband | 19q13.3 | 2.84e-03 | 82 | 44 | 2 | 19q13.3 | |
| GeneFamily | Ring finger proteins|Baculoviral IAP repeat containing|Caspase recruitment domain containing | 6.44e-05 | 8 | 28 | 2 | 419 | |
| GeneFamily | Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing | 3.87e-03 | 206 | 28 | 3 | 682 | |
| GeneFamily | Actins|Deafness associated genes | 1.32e-02 | 113 | 28 | 2 | 1152 | |
| Disease | total hip arthroplasty, osteoarthritis | 1.57e-03 | 42 | 41 | 2 | EFO_0009806, MONDO_0005178 | |
| Disease | cup-to-disc ratio measurement | 2.94e-03 | 430 | 41 | 4 | EFO_0006939 | |
| Disease | asthma | 3.70e-03 | 751 | 41 | 5 | MONDO_0004979 |
| Peptide | Gene | Start | Entry |
|---|---|---|---|
| PSWKDFWKPVGPALH | 56 | Q6ZRU5 | |
| HLDQTGNWPWTSPKD | 416 | Q9H2F5 | |
| WGAPFPAPKDDWAAA | 61 | P47902 | |
| RPRAWGAAAPSAPHW | 61 | O75077 | |
| WSPFPHGGWTDTSEP | 106 | A4D250 | |
| TYPHPRSSPAWADWG | 391 | C9J069 | |
| WAGWGHASENPKLPE | 206 | Q13085 | |
| AAAHIGPAPDPEDWW | 21 | O75493 | |
| GPAPDPEDWWSYKDN | 26 | O75493 | |
| GDPGAMEPWALPTWH | 11 | O95153 | |
| GHWPVPESFWPDQNS | 281 | Q9UL03 | |
| ASPWTQPGVHGPWTE | 161 | Q96DU7 | |
| EQWAWSKPNISGPSP | 266 | Q6P3S6 | |
| VFPGPPASSHWEFWV | 16 | Q8WZ33 | |
| PSPVSWNWNSKDVGP | 146 | P04066 | |
| SATPHLSPPDWWKKA | 616 | Q6AI08 | |
| EATVHWAPPTWPSHK | 146 | Q6UWB1 | |
| HDPWEPKPDWAHTGS | 116 | Q15599 | |
| WTKWFDVDFPSPGPH | 3526 | P98088 | |
| KETAHWKPPPWNDVD | 56 | O75306 | |
| PKEDPWEQHAKWYPG | 51 | Q96P09 | |
| DSAWPHEEQLPGSWK | 3451 | Q8TD57 | |
| VWQPSPDTWHPREQS | 266 | Q6P2H3 | |
| GTPADKPQREWHNSW | 131 | Q9BRP7 | |
| PSWPQKVIWHGSSPH | 1316 | P39059 | |
| LWSDVVSHPPEGPWQ | 291 | P28340 | |
| EWPQNGDHWSRKWPP | 61 | Q8NEE0 | |
| GDHWSRKWPPPCAFT | 66 | Q8NEE0 | |
| FWGWKSLEHPSGPSD | 1546 | A6NES4 | |
| KSGAQATWTELPWPH | 386 | P02790 | |
| WGEPPKPKSQHWGDG | 571 | Q9HCJ0 | |
| DPTSPQPHNWVWLGT | 886 | Q24JP5 | |
| DTYPWAASPQQHEWP | 2396 | Q8IVL1 | |
| HPVQPWASLSPEGWQ | 386 | Q8NDX1 | |
| PPAEDWKPQSSHWGA | 331 | Q05823 | |
| ESWGQPEAWEEKPTH | 1486 | Q9H2D6 | |
| PWSEASCHPGPGDAW | 836 | Q9NRC6 | |
| HPQVTPTDDSNPWWA | 311 | Q03154 | |
| GQWFPESQSWHPSVP | 876 | Q9H2X0 | |
| ESPDVGDFPHEWTWK | 496 | Q7Z3I7 | |
| PACHGIWSKWAPPLE | 196 | Q9P2U8 | |
| GLTDWKPSEDPWEQH | 306 | P98170 | |
| PGLWSPAHSPWSSDI | 1221 | Q96PX9 | |
| DIPSPWEAVGHAWDA | 181 | Q96FX7 | |
| GNGMSWEPPPWVTAH | 356 | Q969W1 | |
| SWRDPGPAQSPDVHW | 141 | P59923 | |
| PSWAPEDAWMGTHPK | 31 | Q8WW01 | |
| PACHGMWSKWAPPLE | 201 | Q8NDX2 | |
| PAPGRWWSFQPHKAF | 116 | Q6UXV3 | |
| DTWPHWHGPPAEGVE | 651 | Q8N1T3 |