Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glycogen phosphorylase activity	PYGB PYGM	1.28e-04	3	131	2	GO:0008184
GeneOntologyMolecularFunction	G protein-coupled receptor activity	TPRA1 GPR17 OR2B2 GPR39 OR52P1 OPRL1 OR1N1 PROKR1 CELSR1 OR52A5 PROKR2 BRS3 OR51M1 OR52E6 CXCR2 OR1L4	2.24e-04	884	131	16	GO:0004930
GeneOntologyMolecularFunction	telomeric D-loop binding	POT1 RECQL4	2.54e-04	4	131	2	GO:0061821
GeneOntologyMolecularFunction	1,4-alpha-oligoglucan phosphorylase activity	PYGB PYGM	4.22e-04	5	131	2	GO:0004645
GeneOntologyMolecularFunction	helicase activity	SETX ZNFX1 SUPV3L1 MOV10L1 RECQL4 TDRD12	6.18e-04	158	131	6	GO:0004386
GeneOntologyMolecularFunction	D-loop DNA binding	POT1 RECQL4	6.30e-04	6	131	2	GO:0062037
Domain	ARM-type_fold	USP34 LRRK2 ZNFX1 HEATR1 UNC45A URB1 ARID2 ANKAR NUP188 ATM STAG3 KPNA3	3.50e-06	339	127	12	IPR016024
Domain	PHOSPHORYLASE	PYGB PYGM	1.37e-04	3	127	2	PS00102
Domain	Glycg_phsphrylas	PYGB PYGM	1.37e-04	3	127	2	IPR011833
Domain	Glyco_trans_35	PYGB PYGM	1.37e-04	3	127	2	IPR000811
Domain	Phosphorylase	PYGB PYGM	1.37e-04	3	127	2	PF00343
Domain	ARM-like	SETX LRRK2 HEATR1 UNC45A ARID2 ANKAR STAG3 KPNA3	5.23e-04	270	127	8	IPR011989
Domain	GPCR_Rhodpsn_7TM	GPR17 OR2B2 GPR39 OPRL1 OR1N1 PROKR1 OR52A5 PROKR2 BRS3 OR51M1 OR52E6 CXCR2 OR1L4	6.48e-04	670	127	13	IPR017452
Domain	7tm_1	GPR17 OR2B2 GPR39 OPRL1 OR1N1 PROKR1 OR52A5 PROKR2 BRS3 OR51M1 OR52E6 CXCR2 OR1L4	7.13e-04	677	127	13	PF00001
Domain	G_PROTEIN_RECEP_F1_1	GPR17 OR2B2 GPR39 OPRL1 OR1N1 PROKR1 OR52A5 PROKR2 BRS3 OR51M1 OR52E6 CXCR2 OR1L4	7.95e-04	685	127	13	PS00237
Domain	G_PROTEIN_RECEP_F1_2	GPR17 OR2B2 GPR39 OPRL1 OR1N1 PROKR1 OR52A5 PROKR2 BRS3 OR51M1 OR52E6 CXCR2 OR1L4	8.61e-04	691	127	13	PS50262
Domain	GPCR_Rhodpsn	GPR17 OR2B2 GPR39 OPRL1 OR1N1 PROKR1 OR52A5 PROKR2 BRS3 OR51M1 OR52E6 CXCR2 OR1L4	8.72e-04	692	127	13	IPR000276
Domain	Ricin_B_lectin	GALNT14 MAB21L2 GALNT13	1.09e-03	30	127	3	IPR000772
Domain	Arm	UNC45A ANKAR KPNA3	1.20e-03	31	127	3	PF00514
Domain	-	RASGRF2 KIF1B APBA3 MTMR6 CCM2 PLCL2 PLCG1 FAM43A PSD4	1.42e-03	391	127	9	2.30.29.30
Domain	NPY_rcpt	PROKR1 PROKR2	1.60e-03	9	127	2	IPR000611
Domain	RFX_DNA_binding	RFX2 ARID2	1.60e-03	9	127	2	PF02257
Domain	DNA-bd_RFX	RFX2 ARID2	1.60e-03	9	127	2	IPR003150
Domain	RFX_DBD	RFX2 ARID2	1.60e-03	9	127	2	PS51526
Domain	Rap_GAP_dom	SIPA1L3 RALGAPB	2.42e-03	11	127	2	IPR000331
Domain	RAPGAP	SIPA1L3 RALGAPB	2.42e-03	11	127	2	PS50085
Domain	-	AANAT ATAT1 CFAP61	2.52e-03	40	127	3	3.40.630.30
Domain	PH_dom-like	RASGRF2 KIF1B APBA3 MTMR6 CCM2 PLCL2 PLCG1 FAM43A PSD4	2.55e-03	426	127	9	IPR011993
Domain	PTB/PI_dom	APBA3 CCM2 FAM43A	2.71e-03	41	127	3	IPR006020
Domain	Acyl_CoA_acyltransferase	AANAT ATAT1 CFAP61	3.54e-03	45	127	3	IPR016181
Domain	Armadillo	UNC45A ANKAR KPNA3	4.00e-03	47	127	3	IPR000225
Domain	-	LRRK2 HEATR1 UNC45A ANKAR STAG3 KPNA3	4.13e-03	222	127	6	1.25.10.10
Domain	EF-hand_like	PLCL2 PLCG1	4.55e-03	15	127	2	PF09279
Domain	PI-PLC-Y	PLCL2 PLCG1	4.55e-03	15	127	2	PF00387
Domain	PLCYc	PLCL2 PLCG1	4.55e-03	15	127	2	SM00149
Domain	PLipase_C_Pinositol-sp_Y	PLCL2 PLCG1	4.55e-03	15	127	2	IPR001711
Domain	PIPLC_Y_DOMAIN	PLCL2 PLCG1	4.55e-03	15	127	2	PS50008
Domain	PI-PLC_fam	PLCL2 PLCG1	4.55e-03	15	127	2	IPR001192
Domain	PLC_EF-hand-like	PLCL2 PLCG1	4.55e-03	15	127	2	IPR015359
Domain	PI-PLC-X	PLCL2 PLCG1	6.54e-03	18	127	2	PF00388
Domain	PLCXc	PLCL2 PLCG1	6.54e-03	18	127	2	SM00148
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	USP34 SETX CAMTA2 HEATR1 GCNT2 LCLAT1 KIAA0753 MTMR6 URB1 KCNJ8 HPS1 PLCL2 LRP2 TYW1 PLCG1 NUP188 HERC4 KPNA3	1.62e-07	1084	132	18	11544199
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	USP34 TPRA1 NUP85 BCAS3 SIPA1L3 HECTD4 ZDHHC8 DUS1L URB1 CELSR1 AATK CLCN7 CCDC3 PYGB PLCG1 NUP188 TRIB1	1.05e-06	1105	132	17	35748872
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	CCDC170 IPPK SETX RNF213 URB1 ARHGEF33 RECQL4 LRP2 NUP188 ATM CTPS1 CXCR2 DOP1B	4.92e-06	736	132	13	29676528
Pubmed	Expression of prokineticin receptors in mouse cultured astrocytes and involvement in cell proliferation.	PROKR1 PROKR2	1.43e-05	2	132	2	16901473
Pubmed	Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor.	PROKR1 PROKR2	1.43e-05	2	132	2	11886876
Pubmed	Modeling of human prokineticin receptors: interactions with novel small-molecule binders and potential off-target drugs.	PROKR1 PROKR2	1.43e-05	2	132	2	22132188
Pubmed	Functional Heterodimerization between the G Protein-Coupled Receptor GPR17 and the Chemokine Receptors 2 and 4: New Evidence.	GPR17 CXCR2	1.43e-05	2	132	2	36613703
Pubmed	Prokineticin receptor variants (PKR1-I379V and PKR2-V331M) are protective genotypes in human early pregnancy.	PROKR1 PROKR2	1.43e-05	2	132	2	23687280
Pubmed	The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor.	EGLN3 KIF1B	1.43e-05	2	132	2	18334619
Pubmed	Ubiquitin-specific protease 34 in macrophages limits CD8 T cell-mediated onset of vitiligo in mice.	USP34 ATM	1.43e-05	2	132	2	37043976
Pubmed	Mutations in beta-myosin S2 that cause familial hypertrophic cardiomyopathy (FHC) abolish the interaction with the regulatory domain of myosin-binding protein-C.	MYBPH MYBPC3	1.43e-05	2	132	2	10024460
Pubmed	Rothmund-Thomson Syndrome	ANAPC1 RECQL4	1.43e-05	2	132	2	20301415
Pubmed	Association between polymorphisms of prokineticin receptor (PKR1 rs4627609 and PKR2 rs6053283) and recurrent pregnancy loss.	PROKR1 PROKR2	1.43e-05	2	132	2	26984842
Pubmed	Isoform-selective regulation of glycogen phosphorylase by energy deprivation and phosphorylation in astrocytes.	PYGB PYGM	1.43e-05	2	132	2	25130497
Pubmed	Polymorphisms in GEMIN4 and AGO1 Genes Are Associated with the Risk of Lung Cancer: A Case-Control Study in Chinese Female Non-Smokers.	AGO1 GEMIN4	1.43e-05	2	132	2	27669275
Pubmed	Genetic and physical delineation of the region overlapping the progressive motor neuropathy (pmn) locus on mouse chromosome 13.	HEATR1 RYR2 GNG4	1.89e-05	14	132	3	11472062
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	USP34 SIPA1L3 RALGAPB URB1 AATK RHOBTB2 DOP1B	2.57e-05	225	132	7	12168954
Pubmed	USP9X promotes apoptosis in cholangiocarcinoma by modulation expression of KIF1Bβ via deubiquitinating EGLN3.	EGLN3 KIF1B	4.28e-05	3	132	2	34112167
Pubmed	The chemokine Bv8/prokineticin 2 is up-regulated in inflammatory granulocytes and modulates inflammatory pain.	PROKR1 PROKR2	4.28e-05	3	132	2	19667192
Pubmed	Revisiting the role of hCG: new regulation of the angiogenic factor EG-VEGF and its receptors.	PROKR1 PROKR2	4.28e-05	3	132	2	22138749
Pubmed	Divergent roles of prokineticin receptors in the endothelial cells: angiogenesis and fenestration.	PROKR1 PROKR2	4.28e-05	3	132	2	20023120
Pubmed	Gene-gene interactions and risk of recurrent miscarriages in carriers of endocrine gland-derived vascular endothelial growth factor and prokineticin receptor polymorphisms.	PROKR1 PROKR2	4.28e-05	3	132	2	25064403
Pubmed	Placental expression of EG-VEGF and its receptors PKR1 (prokineticin receptor-1) and PKR2 throughout mouse gestation.	PROKR1 PROKR2	4.28e-05	3	132	2	17531315
Pubmed	Antagonism of the Prokineticin System Prevents and Reverses Allodynia and Inflammation in a Mouse Model of Diabetes.	PROKR1 PROKR2	4.28e-05	3	132	2	26730729
Pubmed	ATM-dependent activation of SIM2s regulates homologous recombination and epithelial-mesenchymal transition.	SIM2 ATM	4.28e-05	3	132	2	30531838
Pubmed	Polymorphisms of endocrine gland-derived vascular endothelial growth factor gene and its receptor genes are associated with recurrent pregnancy loss.	PROKR1 PROKR2	4.28e-05	3	132	2	20847187
Pubmed	Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to β-arrestin 2.	PROKR1 PROKR2	4.28e-05	3	132	2	33811988
Pubmed	The SWI/SNF chromatin remodeling factor DPF3 regulates metastasis of ccRCC by modulating TGF-β signaling.	CCM2 PYGB PYGM CTPS1	5.82e-05	55	132	4	35945219
Pubmed	The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.	USP34 SETX RNF213 HEATR1 PYGB ATM CTPS1	6.73e-05	262	132	7	36880596
Pubmed	The endocrine-gland-derived VEGF homologue Bv8 promotes angiogenesis in the testis: Localization of Bv8 receptors to endothelial cells.	PROKR1 PROKR2	8.54e-05	4	132	2	12604792
Pubmed	Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression.	LRRK2 AGO1	8.54e-05	4	132	2	20671708
Pubmed	Identification of pathogenic variants in genes related to channelopathy and cardiomyopathy in Korean sudden cardiac arrest survivors.	RYR2 MYBPC3	8.54e-05	4	132	2	28202948
Pubmed	LRRK2 interacts with ATM and regulates Mdm2-p53 cell proliferation axis in response to genotoxic stress.	LRRK2 ATM	8.54e-05	4	132	2	28973420
Pubmed	Molecular cloning and characterization of prokineticin receptors.	PROKR1 PROKR2	8.54e-05	4	132	2	12427552
Pubmed	The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy.	PROKR1 PROKR2	8.54e-05	4	132	2	16763065
Pubmed	Ras-guanine-nucleotide-releasing factors 1 and 2 interact with PLCγ at focal adhesions to enable IL-1-induced Ca(2+) signalling, ERK activation and MMP-3 expression.	RASGRF2 PLCG1	8.54e-05	4	132	2	23145787
Pubmed	Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle.	PROKR1 PROKR2	8.54e-05	4	132	2	15126578
Pubmed	R-loops in proliferating cells but not in the brain: implications for AOA2 and other autosomal recessive ataxias.	SETX ATM	8.54e-05	4	132	2	24637776
Pubmed	Abnormal Pain Sensation in Mice Lacking the Prokineticin Receptor PKR2: Interaction of PKR2 with Transient Receptor Potential TRPV1 and TRPA1.	PROKR1 PROKR2	8.54e-05	4	132	2	31883821
Pubmed	Rac1/osmosensing scaffold for MEKK3 contributes via phospholipase C-gamma1 to activation of the osmoprotective transcription factor NFAT5.	CCM2 PLCG1	8.54e-05	4	132	2	21712438
Pubmed	Prokineticins in central and peripheral control of human reproduction.	PROKR1 PROKR2	8.54e-05	4	132	2	26574895
Pubmed	Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.	POT1 ATM	8.54e-05	4	132	2	17687332
Pubmed	ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres.	POT1 ATM	8.54e-05	4	132	2	26586433
Pubmed	Prokineticin Ligands and Receptors Are Expressed in the Human Fetal Ovary and Regulate Germ Cell Expression of COX2.	PROKR1 PROKR2	8.54e-05	4	132	2	26192875
Pubmed	Ribosomes guide pachytene piRNA formation on long intergenic piRNA precursors.	PNLDC1 MOV10L1	8.54e-05	4	132	2	32015435
Pubmed	Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding.	GALNT14 GALNT13 LRP2	1.02e-04	24	132	3	31740596
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	SETX BCAS3 PARP8 SIPA1L3 KIF1B RALGAPB NCKIPSD UNC45A ATAT1 KIAA0753 CAMSAP2 DOP1B	1.14e-04	861	132	12	36931259
Pubmed	Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis.	POT1 ATM	1.42e-04	5	132	2	17948054
Pubmed	RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance.	POT1 RECQL4	1.42e-04	5	132	2	22039056
Pubmed	Paracrine Interaction of Cancer Stem Cell Populations Is Regulated by the Senescence-Associated Secretory Phenotype (SASP).	POT1 CXCR2	1.42e-04	5	132	2	31043491
Pubmed	ATM activation is impaired in human cells defective in RecQL4 helicase activity.	RECQL4 ATM	1.42e-04	5	132	2	30594395
Pubmed	Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association.	ATM KPNA3	1.42e-04	5	132	2	15929992
Pubmed	Expression of PROKR1 and PROKR2 in human enteric neural precursor cells and identification of sequence variants suggest a role in HSCR.	PROKR1 PROKR2	1.42e-04	5	132	2	21858136
Pubmed	Mouse endocrine gland-derived vascular endothelial growth factor: a distinct expression pattern from its human ortholog suggests different roles as a regulator of organ-specific angiogenesis.	PROKR1 PROKR2	1.42e-04	5	132	2	12746324
Pubmed	Defining the membrane proteome of NK cells.	NUP85 RNF213 HEATR1 TUBGCP2 LCLAT1 CLCN7 PREP RECQL4 GEMIN4 PYGB NUP188 CTPS1 ALG12 PSD4	1.48e-04	1168	132	14	19946888
Pubmed	The DNA sequence and comparative analysis of human chromosome 20.	RALGAPB ZNFX1 PTPRT OPRL1 NKAIN4 PROKR2 PYGB PLCG1 CFAP61	1.67e-04	517	132	9	11780052
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	TPRA1 BCAS3 SIPA1L3 KIF1B RALGAPB HECTD4 RNF213 ATAT1 INTS3 OPRL1 TTLL11 ANKAR TBCK PLCG1 GNG4 ALG12	1.72e-04	1489	132	16	28611215
Pubmed	Characterising the dynamics of placental glycogen stores in the mouse.	GJB3 PYGB PYGM	1.82e-04	29	132	3	32798765
Pubmed	Mapping of QTLs for oral alcohol self-administration in B6.C and B6.I quasi-congenic RQI strains.	TPRA1 PROKR1 KCNJ8	2.01e-04	30	132	3	17273929
Pubmed	Prokineticin-1 modulates proliferation and differentiation of enteric neural crest cells.	PROKR1 PROKR2	2.12e-04	6	132	2	17324478
Pubmed	SOCS1 links cytokine signaling to p53 and senescence.	SOCS1 ATM	2.12e-04	6	132	2	20005840
Pubmed	Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain.	RALGAPB MRPL28 AGO1 PLCL2 CTPS1	2.23e-04	143	132	5	32560809
Pubmed	Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.	BCAS3 LRRK2 GALNT13 RYR2 AATK ANAPC1 ANKAR MOV10L1 HPS1 TRIB1 KPNA3	2.87e-04	814	132	11	23251661
Pubmed	Potential protein partners for the N-terminal domain of human topoisomerase I revealed by phage display.	GEMIN4 PYGM ATM	2.93e-04	34	132	3	12549820
Pubmed	Telomere protection by TPP1/POT1 requires tethering to TIN2.	POT1 ATM	2.97e-04	7	132	2	22099311
Pubmed	Single-stranded DNA-binding protein hSSB1 is critical for genomic stability.	INTS3 ATM	2.97e-04	7	132	2	18449195
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	PARP8 SIPA1L3 KIF1B RALGAPB NCKIPSD TUBGCP2 KIAA0753 ANAPC1	3.17e-04	446	132	8	24255178
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	USP34 SETX POT1 INTS3 RECQL4 CENPI GEMIN4 ATM	3.51e-04	453	132	8	29656893
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	USP34 NUP85 RNF213 MRPL28 HEATR1 UNC45A MAB21L2 TUBGCP2 LCLAT1 URB1 GEMIN4 NUP188 ATM CTPS1 KPNA3	3.86e-04	1440	132	15	30833792
Pubmed	Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in MicroRNA processing genes.	AGO1 GEMIN4	3.94e-04	8	132	2	20211803
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	NUP85 SIPA1L3 TUBGCP2 FBXO38 URB1 NUDT5 ANAPC1 ARID2 RECQL4 PYGM NUP188 ATM KPNA3	4.68e-04	1155	132	13	20360068
Pubmed	Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure.	NUP85 NUP188 KPNA3	4.76e-04	40	132	3	37516964
Pubmed	BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage.	SETX POT1	5.06e-04	9	132	2	34112789
Pubmed	Misreading of termination codons in eukaryotes by natural nonsense suppressor tRNAs.	OPRL1 AGO1	5.06e-04	9	132	2	11726686
Pubmed	Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2.	PROKR1 PROKR2	5.06e-04	9	132	2	16537498
Pubmed	Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.	PARP8 KIF1B KIAA0753 PREP STAG3	5.07e-04	171	132	5	28700664
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	HEATR1 TUBGCP2 INTS3 NUDT5 ATM CTPS1 KPNA3	5.51e-04	370	132	7	22922362
Pubmed	Association of a common AGO1 variant with lung cancer risk: a two-stage case-control study.	AGO1 GEMIN4	6.31e-04	10	132	2	20721975
Pubmed	A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints.	USP34 ATM	6.31e-04	10	132	2	17478428
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	SIPA1L3 RALGAPB RNF213 RB1CC1 PTPRT KIAA0753 FBXO38 MTMR6 NUDT5 CLCN7 PLCL2 KPNA3	6.75e-04	1049	132	12	27880917
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	USP34 SIPA1L3 KIF1B URB1	7.05e-04	105	132	4	9628581
Pubmed	Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome.	SIM2 DOP1B	7.69e-04	11	132	2	9503011
Pubmed	Cardiac disease and arrhythmogenesis: Mechanistic insights from mouse models.	RYR2 MYBPC3	7.69e-04	11	132	2	27766308
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	GGNBP2 SETX NUP85 RALGAPB ZNFX1 INTS3 SUPV3L1 RECQL4 PYGB	8.72e-04	650	132	9	38777146
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	USP34 HEATR1 URB1 ANAPC1 PREP GEMIN4 PYGB NUP188 ATM	9.00e-04	653	132	9	22586326
Pubmed	A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library.	TPRA1 BEND5	9.20e-04	12	132	2	9776767
Pubmed	Large-scale cDNA transfection screening for genes related to cancer development and progression.	FBXO38 CCM2 ALG12 FAM43A	9.58e-04	114	132	4	15498874
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KIF1B RALGAPB CAMTA2 RHOBTB2 PLCL2 CAMSAP2 DOP1B	9.61e-04	407	132	7	12693553
Pubmed	Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis.	MOV10L1 ATM	1.26e-03	14	132	2	21079677
Pubmed	Cell-autonomous involvement of Mab21l1 is essential for lens placode development.	MAB21L2 CRYGA	1.26e-03	14	132	2	12642482
Pubmed	Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study.	GALNT13 GNG4	1.26e-03	14	132	2	17903295
Pubmed	Pot1a prevents telomere dysfunction and ATM-dependent neuronal loss.	POT1 ATM	1.26e-03	14	132	2	24899707
Pubmed	Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis.	ATM STAG3	1.26e-03	14	132	2	22346761
Pubmed	BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein.	LRRK2 MTMR6 PYGM	1.35e-03	57	132	3	27433848
Pubmed	Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters.	OR52A5 OR51M1	1.45e-03	15	132	2	11121057
Pubmed	Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes.	OR52A5 OR51M1	1.45e-03	15	132	2	10220430
Pubmed	Localization of the muscle, liver, and brain glycogen phosphorylase genes on linkage maps of mouse chromosomes 19, 12, and 2, respectively.	PYGB PYGM	1.45e-03	15	132	2	2575583
Pubmed	Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus.	PROKR1 PROKR2	1.45e-03	15	132	2	12024206
Pubmed	Identification of potential protein interactors of Lrrk2.	LRRK2 AGO1	1.45e-03	15	132	2	17400507
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	USP34 NUP85 HEATR1 URB1 ANAPC1 NUP188 CTPS1 KPNA3	1.56e-03	571	132	8	37167062
Cytoband	22q13.33	MOV10L1 SELENOO ALG12	1.82e-04	38	132	3	22q13.33
Cytoband	9q33.2	OR1N1 TTLL11 OR1L4	1.97e-04	39	132	3	9q33.2
Cytoband	2p23.1	GALNT14 LCLAT1	2.27e-04	8	132	2	2p23.1
GeneFamily	UPF1 like RNA helicases	SETX ZNFX1 MOV10L1	2.25e-05	11	95	3	1169
GeneFamily	Prokineticin receptors	PROKR1 PROKR2	2.73e-05	2	95	2	216
GeneFamily	Glycogen phosphorylases	PYGB PYGM	8.17e-05	3	95	2	437
GeneFamily	Fibronectin type III domain containing\|I-set domain containing\|Myosin binding proteins	MYBPH MYBPC3	7.49e-04	8	95	2	658
GeneFamily	Fibronectin type III domain containing	MYBPH INSRR PTPRT FNDC9 MYBPC3	1.56e-03	160	95	5	555
GeneFamily	Olfactory receptors, family 52	OR52P1 OR52A5 OR52E6	2.17e-03	49	95	3	165
CoexpressionAtlas	dev gonad_e12.5_M_GermCellTestis_Oct_top-relative-expression-ranked_1000	EGLN3 SETX NUP85 POT1 HEATR1 PNLDC1 GCNT2 GJB3 URB1 MOV10L1 CENPI NUP188 ATM CTPS1 STAG3 TDRD12	1.77e-05	795	125	16	gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_1000
CoexpressionAtlas	dev gonad_e12.5_M_GermCellTestis_Oct_top-relative-expression-ranked_500	EGLN3 POT1 HEATR1 PNLDC1 GJB3 URB1 MOV10L1 ATM CTPS1 STAG3 TDRD12	1.85e-05	387	125	11	gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_500
CoexpressionAtlas	dev gonad_e13.5_M_GermCell_Oct_top-relative-expression-ranked_1000	SETX BCAS3 POT1 RNF213 HEATR1 PNLDC1 GCNT2 GJB3 URB1 MOV10L1 NUP188 ATM CFAP61 CTPS1 STAG3 TDRD12	2.23e-05	810	125	16	gudmap_dev gonad_e13.5_M_GermCell_Oct_1000
CoexpressionAtlas	dev gonad_e13.5_M_GermCell_Oct_top-relative-expression-ranked_500	SETX POT1 HEATR1 PNLDC1 GJB3 URB1 MOV10L1 ATM CTPS1 STAG3 TDRD12	2.29e-05	396	125	11	gudmap_dev gonad_e13.5_M_GermCell_Oct_500
CoexpressionAtlas	dev gonad_e12.5_F_GermCellOvary_Oct_top-relative-expression-ranked_1000	CCDC170 EGLN3 SETX POT1 RNF213 HEATR1 PNLDC1 GJB3 URB1 MOV10L1 CENPI NUP188 ATM CTPS1 STAG3 TDRD12	2.66e-05	822	125	16	gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_1000
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_1000	SETX BCAS3 POT1 HEATR1 PNLDC1 GJB3 URB1 MOV10L1 CENPI NUP188 ATM CFAP61 CTPS1 STAG3 TDRD12	9.71e-05	820	125	15	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_1000
CoexpressionAtlas	DevelopingGonad_e14.5_ testes_emap-6710_k-means-cluster#4_top-relative-expression-ranked_1000	GGNBP2 BCAS3 HEATR1 PNLDC1 PROKR2 TDRD12	1.55e-04	136	125	6	gudmap_developingGonad_e14.5_ testes_1000_k4
CoexpressionAtlas	dev gonad_e13.5_M_GermCell_Oct_k-means-cluster#1_top-relative-expression-ranked_1000	SETX BCAS3 POT1 HEATR1 PNLDC1 URB1 NUP188 ATM CTPS1	1.60e-04	333	125	9	gudmap_dev gonad_e13.5_M_GermCell_Oct_k1_1000
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SIM2 PTPRT GALNT13 RYR2 AADACL2 MOV10L1 LRP2	5.12e-07	160	132	7	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SIM2 PTPRT GALNT13 RYR2 AADACL2 MOV10L1 LRP2	5.12e-07	160	132	7	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZNFX1 SIM2 RFX2 MCTP1 SUPV3L1 TRIB1 CXCR2	1.22e-06	182	132	7	dc32f8f6a3b13918eb8e93c018f5823d86344080
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	RNF213 HEATR1 URB1 ARID2 TBCK TYW1 DOP1B	1.68e-06	191	132	7	9454f642c3621370fa23640b631301346b300950
ToppCell	facs-Liver-Non-hepatocytes-3m-Myeloid-neutrophil\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	POT1 GCNT2 GALNT13 MCTP1 CXCR2 MYBPC3	9.59e-06	164	132	6	8e6dbddacd56a07769163813e3ebfad13302bb62
ToppCell	356C-Myeloid-Monocyte-CD16+_Monocyte\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	BCAS3 PNLDC1 DUOX1 AATK CLCN7 CGRRF1	1.06e-05	167	132	6	7e61c5d2cdcfa6a2e3484b3994aec6b64ad75f07
ToppCell	356C-Myeloid-Monocyte-CD16+_Monocyte\|Monocyte / Donor, Lineage, Cell class and subclass (all cells)	BCAS3 PNLDC1 DUOX1 AATK CLCN7 CGRRF1	1.26e-05	172	132	6	9dca1542145d88559527db7e0f6ad150df59ca2d
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF1B LCLAT1 KIAA0753 CLCN7 CAMSAP2 TRIB1	1.63e-05	180	132	6	be10fe5bf7c3a671c42704ce7dd8226ab6896794
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIF1B LCLAT1 KIAA0753 CLCN7 CAMSAP2 TRIB1	1.63e-05	180	132	6	3b747a517ce75ef2ff09011c037dad7b01ed3e03
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	USP34 PARP8 RNF213 ARID2 ATM HERC4	1.68e-05	181	132	6	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal-podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	POT1 RFX2 PROKR1 AATK NKD1 NKAIN4	1.90e-05	185	132	6	ca69499ba8c39b7ed6717d05685d6f70066a77bd
ToppCell	pdx\|World / Sample and Cell Type and Tumor Cluster (all cells)	CCDC170 RASGRF2 SIPA1L3 HECTD4 NKD1 TBCK	1.96e-05	186	132	6	de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCell	pdx-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	CCDC170 RASGRF2 SIPA1L3 HECTD4 NKD1 TBCK	1.96e-05	186	132	6	0b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GALNT14 SIPA1L3 LRRK2 SIM2 PTPRT CELSR1	2.08e-05	188	132	6	63a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CCDC170 SETX ANKAR ATM HERC4 PAQR7	2.21e-05	190	132	6	63018acb7ad80415e861643162abdc2e55968ee4
ToppCell	Adult-Epithelial\|Adult / Lineage, Cell type, age group and donor	GPR39 LRRK2 GCNT2 DUOX1 CELSR1 RHOBTB2	2.34e-05	192	132	6	efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	GPR39 LRRK2 GCNT2 DUOX1 RHOBTB2 LRP2	2.86e-05	199	132	6	725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCell	Parenchymal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	GPR39 SIPA1L3 GCNT2 DUOX1 CELSR1 RHOBTB2	2.86e-05	199	132	6	5cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	SETX PARP8 RNF213 PLCG1 CXCR2 PSD4	2.94e-05	200	132	6	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6-Excitatory_Neuron.Slc17a7.Syt6-Etv1_(Deep_layer_pyramidal_cells-Etv1_typically_marks_layer_5b,_but_some_expression_in_layer_6,_especially_in_medial_regions_like_cingulate)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	AANAT PNLDC1 SIM2 TDRD12	3.04e-05	60	132	4	f20230c11a2ca2f66650e53ea6eaa301402294c0
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6-Excitatory_Neuron.Slc17a7.Syt6-Etv1_(Deep_layer_pyramidal_cells-Etv1_typically_marks_layer_5b,_but_some_expression_in_layer_6,_especially_in_medial_regions_like_cingulate)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	AANAT PNLDC1 SIM2 TDRD12	3.04e-05	60	132	4	71e2aa3da41319c72b4eac30e54c65e65e62a3d9
Drug	Fluticasone propionate [80474-14-2]; Down 200; 8uM; MCF7; HT_HG-U133A	FKBP10 SIPA1L3 TUBGCP2 SIM2 RYR2 HPS1 GSTCD SOCS1 ATM PSD4	2.08e-07	196	131	10	7348_DN
Drug	Isoflupredone acetate [338-98-7]; Down 200; 9.6uM; MCF7; HT_HG-U133A	SIPA1L3 UNC45A RYR2 HPS1 GSTCD LRP2 PLCG1 ATM DOP1B	2.25e-06	198	131	9	5545_DN
Drug	Methiothepin maleate [19728-88-2]; Up 200; 8.4uM; PC3; HT_HG-U133A	FKBP10 GPR17 GPR39 TUBGCP2 KIAA0753 AATK CLCN7 GSTCD MYBPC3	2.34e-06	199	131	9	6312_UP
Drug	Ethynylestradiol 3-methyl ether [72-33-3]; Down 200; 12.8uM; MCF7; HT_HG-U133A	SIPA1L3 APBA3 MTMR6 AGO1 CLCN7 HPS1 PLCG1 ATM GNG4	2.34e-06	199	131	9	3346_DN
Drug	Nomegestrol acetate [58652-20-3]; Down 200; 10.8uM; MCF7; HT_HG-U133A	SIPA1L3 GCNT2 RYR2 RHOBTB2 GSTCD NUP188 ATM PSD4	1.83e-05	196	131	8	5461_DN
Drug	Todralazine hydrochloride [3778-76-5]; Down 200; 14.8uM; HL60; HT_HG-U133A	SIPA1L3 UNC45A TUBGCP2 CLCN7 PREP PLCL2 GEMIN4 ATM	1.83e-05	196	131	8	1841_DN
Drug	Ethamsylate [2624-44-4]; Down 200; 15.2uM; MCF7; HT_HG-U133A	CCDC170 IPPK FKBP10 SIPA1L3 NCKIPSD SIM2 RYR2 ALG12	1.90e-05	197	131	8	7335_DN
Drug	Mepenzolate bromide [76-90-4]; Down 200; 9.6uM; PC3; HT_HG-U133A	USP34 GCNT2 CLCN7 RHOBTB2 PLCG1 CAMSAP2 ALG12 PSD4	1.90e-05	197	131	8	3748_DN
Drug	Clindamycin hydrochloride [21462-39-5]; Down 200; 8.6uM; PC3; HT_HG-U133A	GALNT14 UNC45A SIM2 PREP KCNJ8 PLCL2 ATM STAG3	1.90e-05	197	131	8	5815_DN
Drug	Harmalol hydrochloride dihydrate [6028-07-5]; Down 200; 14.6uM; MCF7; HT_HG-U133A	TPRA1 TUBGCP2 GJB3 CLCN7 LRP2 SOCS1 GNG4 HERC4	1.97e-05	198	131	8	5495_DN
Drug	Isometheptene mucate; Down 200; 8.2uM; MCF7; HT_HG-U133A	USP34 SIPA1L3 POT1 GJB3 CENPI LRP2 ATM GNG4	2.04e-05	199	131	8	5502_DN
Drug	Iobenguane sulfate; Down 200; 10.8uM; MCF7; HT_HG-U133A	SIPA1L3 TUBGCP2 SIM2 GJB3 HPS1 NUP188 ALG12 PSD4	2.04e-05	199	131	8	2878_DN
Drug	Gvapspat amide	RYR2 PYGB PYGM	8.05e-05	15	131	3	CID000125015
Drug	3,5-dimethylphenyl isocyanate	PYGB PYGM	9.82e-05	3	131	2	CID000521488
Drug	5'-deoxy-5'-fluoro-5'-(methylthio)adenosine	PYGB PYGM	9.82e-05	3	131	2	CID000147839
Drug	NSC758405	PYGB PYGM	9.82e-05	3	131	2	CID000003201
Drug	3,5-dinitrophenyl phosphate	PYGB PYGM	9.82e-05	3	131	2	CID000151920
Drug	pyridoxal phosphoglucose	PYGB PYGM	9.82e-05	3	131	2	CID000196007
Drug	5-ethyl-4-hydroxy-2-methyl-3(2H)-furanone	PYGB PYGM	9.82e-05	3	131	2	CID000093111
Drug	adenosine-5'-chloromethylphosphonate	PYGB PYGM	9.82e-05	3	131	2	CID000191554
Drug	hydan	PYGB PYGM	9.82e-05	3	131	2	CID000008360
Drug	EHMF	PYGB PYGM	9.82e-05	3	131	2	CID000033931
Drug	pyridoxal 5'-methylenephosphonate	PYGB PYGM	9.82e-05	3	131	2	CID003082249
Drug	Plp 5'-mpa	PYGB PYGM	9.82e-05	3	131	2	CID003082151
Drug	glucose-1,2-cyclic phosphate	PYGB PYGM	9.82e-05	3	131	2	CID000191723
Drug	3'-FFdUrd	PYGB PYGM	9.82e-05	3	131	2	CID000072260
Drug	2',3',4',5,5'-pentachloro-2-biphenylol	PYGB PYGM	9.82e-05	3	131	2	CID000119518
Drug	AC1L8XK3	PYGB PYGM	9.82e-05	3	131	2	CID000409735
Drug	N-acetyl-N'-beta-D-glucopyranosyl urea	PYGB PYGM	9.82e-05	3	131	2	CID000446801
Drug	riboflavin tetraacetate	PYGB PYGM	9.82e-05	3	131	2	CID000094186
Drug	2,5-dimethyl-3-furanone	PYGB PYGM	9.82e-05	3	131	2	CID000085730
Drug	3,5-dinitrophenol	PYGB PYGM	9.82e-05	3	131	2	CID000011459
Drug	Hexetidine [141-94-6]; Up 200; 11.8uM; HL60; HT_HG-U133A	BCAS3 SIPA1L3 UNC45A PYGB GNG4 CAMSAP2 ALG12	9.98e-05	185	131	7	2457_UP
Drug	Lanatoside C [17575-22-3]; Down 200; 4uM; PC3; HT_HG-U133A	BEND5 KCNJ8 RHOBTB2 HPS1 GEMIN4 ATM PSD4	1.14e-04	189	131	7	3771_DN
Drug	Antimycin A [1397-94-0]; Down 200; 7.2uM; MCF7; HT_HG-U133A	EGLN3 TUBGCP2 RYR2 FBXO38 GJB3 CLCN7 PSD4	1.22e-04	191	131	7	2261_DN
Drug	Carcinine [56897-53-1]; Down 200; 22uM; PC3; HT_HG-U133A	TPRA1 SIPA1L3 CELSR1 HPS1 ALG12 STAG3 PSD4	1.30e-04	193	131	7	4225_DN
Drug	CP-319743 [172078-87-4]; Down 200; 10uM; PC3; HT_HG-U133A	TPRA1 UNC45A URB1 MCTP1 RHOBTB2 HERC4 PSD4	1.34e-04	194	131	7	7537_DN
Drug	Flunisolide [3385-03-3]; Down 200; 9.2uM; PC3; HT_HG-U133A	USP34 BEND5 BCAS3 TUBGCP2 CAMSAP2 ALG12 PSD4	1.34e-04	194	131	7	3747_DN
Drug	Gliquidone [33342-05-1]; Up 200; 7.6uM; HL60; HT_HG-U133A	APBA3 UNC45A SIM2 OPRL1 BRS3 LRP2 ALG12	1.34e-04	194	131	7	3126_UP
Drug	Hesperidin [520-26-3]; Up 200; 6.6uM; MCF7; HT_HG-U133A	FKBP10 POT1 TUBGCP2 PLCG1 ATM HERC4 STAG3	1.38e-04	195	131	7	5313_UP
Drug	Carbimazole [22232-54-8]; Down 200; 21.4uM; MCF7; HT_HG-U133A	FKBP10 RALGAPB GCNT2 TUBGCP2 RYR2 HPS1 LRP2	1.38e-04	195	131	7	5399_DN
Drug	H-AKH	RB1CC1 PYGB PYGM	1.43e-04	18	131	3	CID000123821
Drug	Ifenprodil tartrate [23210-58-4]; Down 200; 8.4uM; HL60; HT_HG-U133A	SIPA1L3 KIF1B TUBGCP2 KIAA0753 LRP2 CAMSAP2 HERC4	1.43e-04	196	131	7	2372_DN
Drug	Kynurenine, 3-hydroxy (R,S) [2147-61-7]; Down 200; 17.8uM; MCF7; HT_HG-U133A	APBA3 GJB3 RHOBTB2 CENPI ATM GNG4 HERC4	1.43e-04	196	131	7	5276_DN
Drug	fludrocortisone acetate; Up 200; 1uM; MCF7; HG-U133A	OPRL1 GJB3 AATK CLCN7 HPS1 CENPI NUP188	1.47e-04	197	131	7	282_UP
Drug	Bendroflumethiazide [73-48-3]; Down 200; 9.4uM; MCF7; HT_HG-U133A	FKBP10 GJB3 RHOBTB2 PLCG1 ATM GNG4 PSD4	1.47e-04	197	131	7	3934_DN
Drug	Isoquinoline, 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro, hydrochloride; Up 200; 16.4uM; PC3; HT_HG-U133A	FKBP10 GPR17 CLCN7 HPS1 LRP2 PLCG1 NUP188	1.47e-04	197	131	7	4226_UP
Drug	Metformin hydrochloride [1115-70-4]; Up 200; 24.2uM; HL60; HT_HG-U133A	RALGAPB KIAA0753 URB1 GSTCD NUP188 CAMSAP2 HERC4	1.47e-04	197	131	7	1858_UP
Drug	Isopropamide iodide [71-81-8]; Down 200; 8.4uM; MCF7; HT_HG-U133A	UNC45A SIM2 RYR2 GJB3 HPS1 GSTCD ALG12	1.47e-04	197	131	7	6781_DN
Drug	Epitiostanol [2363-58-8]; Down 200; 13uM; MCF7; HT_HG-U133A	TPRA1 UNC45A HPS1 CENPI ATM ALG12 PSD4	1.52e-04	198	131	7	4788_DN
Drug	Xamoterol hemifumarate [73210-73-8]; Up 200; 5uM; MCF7; HT_HG-U133A	FKBP10 POT1 TUBGCP2 FBXO38 SOCS1 PLCG1 PSD4	1.52e-04	198	131	7	5363_UP
Drug	Zardaverine [101975-10-4]; Down 200; 15uM; PC3; HT_HG-U133A	USP34 BCAS3 GCNT2 AATK GSTCD GNG4 ALG12	1.57e-04	199	131	7	4209_DN
Drug	Protoveratrine A [143-57-7]; Down 200; 5uM; PC3; HT_HG-U133A	BEND5 UNC45A URB1 CLCN7 KCNJ8 GSTCD ALG12	1.57e-04	199	131	7	6618_DN
Drug	Torsemide [56211-40-6]; Up 200; 11.4uM; HL60; HT_HG-U133A	BCAS3 RYR2 CELSR1 HPS1 PYGB NUP188 CAMSAP2	1.57e-04	199	131	7	2956_UP
Drug	Disulfiram [97-77-8]; Down 200; 13.4uM; MCF7; HT_HG-U133A	GALNT14 SIPA1L3 GCNT2 GJB3 GSTCD GNG4 HERC4	1.57e-04	199	131	7	2215_DN
Drug	Dubinidine [22964-77-8]; Down 200; 14.6uM; PC3; HT_HG-U133A	GALNT14 USP34 FKBP10 BEND5 RYR2 RHOBTB2 GNG4	1.62e-04	200	131	7	5774_DN
Drug	Ethynylestradiol 3-methyl ether [72-33-3]; Down 200; 12.8uM; HL60; HT_HG-U133A	SIPA1L3 APBA3 KIAA0753 CENPI CAMSAP2 HERC4 ALG12	1.62e-04	200	131	7	3008_DN
Drug	Trichlormethiazide [133-67-5]; Down 200; 10.6uM; MCF7; HT_HG-U133A	FKBP10 TPRA1 TUBGCP2 HPS1 PLCG1 GNG4 PSD4	1.62e-04	200	131	7	4783_DN
Drug	galocitabine	PYGB PYGM	1.96e-04	4	131	2	CID000065950
Drug	5-deoxyribose-1-phosphate	PYGB PYGM	1.96e-04	4	131	2	CID000135786
Drug	ingliforib	PYGB PYGM	1.96e-04	4	131	2	CID006451325
Drug	uric acid riboside	PYGB PYGM	1.96e-04	4	131	2	CID000164933
Drug	pseudo-dl-glucose	PYGB PYGM	1.96e-04	4	131	2	CID000125259
Drug	pyridoxal diphosphate	PYGB PYGM	1.96e-04	4	131	2	CID000125696
Drug	2,5-anhydro-D-mannitol 1-phosphate	PYGB PYGM	1.96e-04	4	131	2	CID000189134
Drug	AC1LAMW2	PYGB PYGM	1.96e-04	4	131	2	CID000491364
Drug	FdUrd-C8	PYGB PYGM	1.96e-04	4	131	2	CID000094262
Drug	Mem-CC	PYGB PYGM	1.96e-04	4	131	2	CID003081269
Drug	BCIp4A	PYGB PYGM	1.96e-04	4	131	2	CID000192417
Drug	3'-chloromethotrexate	PYGB PYGM	1.96e-04	4	131	2	CID000097703
Drug	N-nitrosomorpholine	MOV10L1 GSTCD PYGB PYGM	2.29e-04	52	131	4	CID000006046
Disease	uric acid measurement	IPPK USP34 BCAS3 SIPA1L3 INSRR HECTD4 GCNT2 CCM2 SELENOO LRP2 PYGB PYGM HERC4 TRIB1	3.70e-07	610	126	14	EFO_0004761
Disease	Rothmund-Thomson syndrome (is_implicated_in)	ANAPC1 RECQL4	1.81e-05	2	126	2	DOID:2732 (is_implicated_in)
Disease	eosinophil count	CCDC170 FKBP10 PARP8 SIPA1L3 POT1 NCKIPSD HECTD4 ZDHHC8 LCLAT1 CELSR1 CCM2 NKD1 ANAPC1 PLCL2 SOCS1 ATM TRIB1 FAM43A	6.31e-05	1488	126	18	EFO_0004842
Disease	colorectal cancer (is_implicated_in)	POT1 PTPRT ARID2 SOCS1 ATM	1.75e-04	121	126	5	DOID:9256 (is_implicated_in)
Disease	lymphocyte count	CCDC170 IPPK PCDHGC5 BCAS3 KIF1B INSRR HECTD4 GCNT2 PTPRT OPRL1 ANAPC1 SUPV3L1 ATM TRIB1 PSD4 KPNA3	5.14e-04	1464	126	16	EFO_0004587
Disease	renal cell carcinoma	POT1 RHOBTB2 ATM	7.73e-04	42	126	3	EFO_0000681
Disease	urinary 6‑hydroxymelatonin sulfate to creatinine ratio	GALNT14 GALNT13	7.96e-04	10	126	2	EFO_0021488
Disease	Small Lymphocytic Lymphoma	POT1 ATM	7.96e-04	10	126	2	C0855095
Disease	B-CELL MALIGNANCY, LOW-GRADE	POT1 ATM	7.96e-04	10	126	2	C1868683
Disease	cerebral cavernous malformation (implicated_via_orthology)	RNF213 CCM2	9.70e-04	11	126	2	DOID:0060669 (implicated_via_orthology)
Disease	Tachycardia, Ventricular	RYR2 KCNJ8	9.70e-04	11	126	2	C0042514
Disease	Sensory hearing loss	GJB3 LRP2	9.70e-04	11	126	2	C1691779
Disease	Cognitive impairment	PTPRT RYR2	9.70e-04	11	126	2	HP_0100543
Disease	Alcoholic Intoxication, Chronic	RASGRF2 OPRL1 AGO1 ANAPC1 GEMIN4 KPNA3	1.05e-03	268	126	6	C0001973
Disease	unipolar depression, information processing speed, cognitive function measurement	SLC25A46 GALNT13 TBCK	1.07e-03	47	126	3	EFO_0003761, EFO_0004363, EFO_0008354
Disease	hepatocellular carcinoma (is_implicated_in)	KIF1B POT1 ARID2 SOCS1 PLCG1	1.10e-03	181	126	5	DOID:684 (is_implicated_in)
Disease	Charcot-Marie-Tooth Disease	SLC25A46 SETX	1.16e-03	12	126	2	C0007959
Disease	pulse pressure measurement, social deprivation	PLCL2 CTPS1	1.59e-03	14	126	2	EFO_0005763, EFO_0009696
Disease	Antithrombotic agent use measurement	HECTD4 OPRL1 TRIB1	1.70e-03	55	126	3	EFO_0009925
Disease	cystatin C measurement	BCAS3 HECTD4 LRP2 PYGB TRIB1 MYBPC3 TDRD12	1.74e-03	402	126	7	EFO_0004617
Disease	YKL40 measurement	MYBPH TRIB1	1.83e-03	15	126	2	EFO_0004869
Disease	Congenital total cataract	SIPA1L3 GCNT2	2.09e-03	16	126	2	C0266539
Disease	allergic sensitization measurement	SLC25A46 NKD1 ANAPC1	2.39e-03	62	126	3	EFO_0005298
Disease	oral squamous cell carcinoma (is_marker_for)	ARID2 PLCG1 ATM	2.50e-03	63	126	3	DOID:0050866 (is_marker_for)
Disease	anorexia nervosa	NCKIPSD MCTP1 LRP2	3.38e-03	70	126	3	MONDO_0005351
Disease	cardiovascular disease	CCDC170 USP34 BCAS3 OPRL1 NKAIN4 TRIB1 MYBPC3	3.55e-03	457	126	7	EFO_0000319
Disease	BREAST CANCER	RB1CC1 ATM	3.60e-03	21	126	2	114480
Disease	renal system measurement, blood urea nitrogen measurement	BCAS3 HECTD4	3.95e-03	22	126	2	EFO_0004741, EFO_0004742
Disease	Granulomatous Slack Skin	PLCG1 ATM	3.95e-03	22	126	2	C0376407
Disease	myocardial infarction	BCAS3 NCKIPSD HECTD4 CCM2 PLCL2 TRIB1	3.99e-03	350	126	6	EFO_0000612
Disease	hematocrit	EGLN3 BCAS3 KIF1B HECTD4 SIM2 ARID2 PLCL2 LRP2 TRIB1 PSD4 TDRD12	4.10e-03	1011	126	11	EFO_0004348

Protein segments in the cluster

Peptide	Gene	Start	Entry
SPHKLSIVRECLYDR	BEND5	361	Q7L4P6
PLTYILTCQHDLLRD	AADACL2	331	Q6P093
LSTDEIVPYDHLILC	CFAP61	756	Q8NHU2
RIVLCTLDRHLPYDR	AIFM3	221	Q96NN9
LSCVLVLPTRLVYHF	GPR17	106	Q13304
QILHYELLAIRDACI	AGO1	676	Q9UL18
ATPHARIIELLTEAY	APBA3	536	O96018
YLRDLPECISLVHVV	ARHGEF33	361	A8MVX0
DQDSYREIICHLTLP	ARID2	396	Q68CP9
IVLVHYLNVPALEDC	CAMTA2	141	O94983
ELAEEYLDIVREHPC	DUS1L	251	Q6P1R4
FRLPEIYSLHVLEGC	CRYGA	116	P11844
ILRVPIHDIAAVSYV	CCM2	131	Q9BSQ5
ENPFLCTVVAILLHY	CELSR1	2526	Q9NYQ6
PIYDLHCNKRILVVV	BCAS3	186	Q9H6U6
LEKIALEYIVPCLHE	EGLN3	11	Q9H6Z9
LLVAVATVHLVICPY	ALG12	16	Q9BV10
HLRELPALVVYESQA	NKD1	431	Q969G9
VRLLCHLTPSIYTEF	INTS3	736	Q68E01
LQTYRFAEHRPILCV	IPPK	121	Q9H8X2
EPEVHSRCAVILYDI	ANKAR	796	Q7Z5J8
IALPIRDAIYHCREQ	ANAPC1	951	Q9H1A4
VRIACLALGTTEYHP	DUOX1	1306	Q9NRD9
KIPLLECLTRHSYRE	RB1CC1	201	Q8TDY2
EPIIVRLHCSLTQYL	PARP8	206	Q8N3A8
VLAYALDISPVVHRI	PAQR7	211	Q86WK9
QEILPALCVLIYHTD	KPNA3	241	O00505
VLTLSFERYIAICHP	GPR39	126	O43194
IICHVIDKRSPLYDI	KCNJ8	266	Q15842
EKACILVDHLREPLY	MCTP1	311	Q6DN14
LPSRLFYHRELEVCA	MOV10L1	981	Q9BXT6
EEVLTCLGIHLYERL	GGNBP2	296	Q9H3C7
IVPRERDCHDIYNSL	MTMR6	81	Q9Y217
CAYVHTRLSPTVILD	MMRN1	211	Q13201
VVLEHLAPSTLYFLC	FNDC9	61	Q8TBE3
NTYPLTVECLELRHR	GCNT2	371	Q8N0V5
SAYLELDHCIQPAVI	KIF1B	1386	O60333
DPITHDLIISLARYI	LRRC75A	106	Q8NAA5
HAAVSVRPVLLTLYE	DOP1B	116	Q9Y3R5
IDYFCDIHEPLQLLI	LCLAT1	186	Q6UWP7
YIHRPCLQVIEAVLV	CLCN7	406	P51798
YCPELGRVSLELHIE	NUP85	426	Q9BW27
VAICHPLRYSVIITG	OR51M1	136	Q9H341
ALDRYVAICIPLRHA	OR52A5	121	Q9H2C5
ILSHIRILYAVFCLP	OR52E6	216	Q96RD3
PVLQRTLHYECIVLV	NUDT5	66	Q9UKK9
PLDREATSHYIIELL	PCDHGC5	411	Q9Y5F6
LLACISVDRYLAIVH	CXCR2	136	P25025
IYNCTIVDLHFPLAL	HERC4	806	Q5GLZ8
VVLLVSPRFLYLAHC	PPM1N	166	Q8N819
ELPHCENSEIIIRLY	LRRK2	1681	Q5S007
IRELVHRILPVAASY	TUBGCP2	256	Q9BSJ2
LLAYCEAHVREDPLI	GNG4	41	P50150
IIRHPYALTLFEDSV	LRP2	1641	P98164
VAICHPLRYATILTD	OR52P1	126	Q8NH57
EKLRCAIHYREDPLS	HECTD4	3981	Q9Y4D8
ILPLRFVELQVCDHY	GARIN1B	146	Q96KD3
YIAVDEVRVLAHPCR	PTPRT	176	O14522
PLLHRVKEDYTRVVC	GALNT14	211	Q96FL9
RSPHYLLSEVILVDD	GALNT13	141	Q8IUC8
IIYHCDLTKEELEPR	PREP	406	P48147
EVLCHIFRYLPLQDI	FBXO38	36	Q6PIJ6
ELLLERLVCIGYPHE	NT5DC4	41	Q86YG4
DFCQTVLPYLIHDIL	ATM	1836	Q13315
LEDVVIERYHIPRAC	FKBP10	41	Q96AY3
ETIVYARVLALHPEA	CCDC3	41	Q9BQI4
TLLLYECEKHPRETD	MAB21L2	276	Q9Y586
LLHRVTYCVADARLP	FAM43A	136	Q8N2R8
PRLCLEHIYRLEEVT	INSRR	446	P14616
VEPLCILDFYIHESV	ATAT1	116	Q5SQI0
LIACVLPYHETRIFV	HEATR1	131	Q9H583
PDYEIIKCLERLVHS	CCDC170	671	Q8IYT3
LLLHYINCVRDEPVL	CENPI	371	Q92674
AVRCYELLALHLSVI	HPS1	661	Q92902
CPSLLVILHVAYREE	GJB3	86	O75712
VIHIPDRTYKLSCRI	CGRRF1	196	Q99675
LCSHVDEPQLLYAIE	RYR2	1676	Q92736
LYFTLADIVLLPCIH	GSTCD	281	Q8NEC7
LIHFYCPDVVRLEDI	CAMSAP2	261	Q08AD1
ELLEPVCHQLFELYR	FAM126B	51	Q8IXS8
DRFVAICRPLHYSII	OR2B2	121	Q9GZK3
PDLRRDVYLQDIHCV	ARHGAP30	76	Q7Z6I6
IDRLVAICNPLHYDV	OR1L4	121	Q8NGR5
CIVTSYIHIVPAILR	OR1N1	211	Q8NGS0
VDRYVAICHPIRALD	OPRL1	146	P41146
GVCPLYLDEIRHFLT	AANAT	61	Q16613
YLDEIRHFLTLCPEL	AANAT	66	Q16613
PTAEEVHLLLSYLCA	AATK	386	Q6ZMQ8
CDHILYQALVEILIP	RFX2	446	P48378
TLLDHVIFRSIPYEE	RASGRF2	1011	O14827
PEEAIETLLCYLELH	RECQL4	916	O94761
VVVISHCESNPLLYL	TDRD12	456	Q587J7
ILKEYRDHPTLCISL	PNLDC1	471	Q8NA58
HELCTRPEIYFLLVQ	PLCL2	336	Q9UPR0
ILTDHQYLERTPLCA	POT1	336	Q9NUX5
ETYVQLLVARLHCPS	PSD4	976	Q8NDX1
LCLPHLVALTEQYTV	RHOBTB2	581	Q9BYZ6
VICVHDVSSIYRVPL	CTPS1	241	P17812
RPHCIVSVNYVLTEI	SIM2	321	Q14190
VRRVLKLLETPYHCE	SELENOO	616	Q9BVL4
LEYVIPELNIHCLRL	SIPA1L3	586	O60292
PYLLLHERVNELCVE	SETX	121	Q7Z333
VLERYHPTTCTISDL	MYBPH	316	Q13203
IQHIPLSLRVRYVFC	SUPV3L1	561	Q8IYB8
NLAIRYSCPHAIRIE	KIAA0753	46	Q2KHM9
CLFELLEHYVAAPRR	SOCS1	146	O15524
DDFLPLIHVYLQCRT	URB1	1266	O60287
YTLCGLRPEELQHIS	STRC	1596	Q7RTU9
DEGVIRCYLEELLHI	NCKIPSD	406	Q9NZQ3
LLLTCVPVDATHYLA	BRS3	96	P32247
EPSYVEALHSCLQIL	NKAIN4	141	Q8IVV8
LAIAIDRYLAIVHPL	PROKR1	156	Q8TCW9
PCHLYIVEILERRTS	RNF213	2091	Q63HN8
VPHRCLLLLYEDIGT	TPRA1	26	Q86W33
PLHEQVASLIDLCEY	TTLL11	726	Q8NHH1
IADYLLLPLAEREHV	TRIB1	91	Q96RU8
CLHVITLYNRIKREP	PYGM	581	P11217
HRYRDVLPEIRAICI	STAG3	311	Q9UJ98
CSDVILYPLETVLHR	SLC25A46	326	Q96AG3
CLHVVTLYNRIKRDP	PYGB	581	P11216
ILRCVLHLLTYFQDE	NUP188	136	Q5SRE5
EYPVILSIEDHCSIA	PLCG1	406	P19174
LLAIAIDRYLAIVHP	PROKR2	146	Q8NFJ6
CSRLPGHYLRSLEEE	MRPL28	21	Q13084
RRDDPHSLCYDITVI	RAET1L	26	Q5VY80
EVDIPRCHQYDELLS	TBCK	506	Q8TEA7
INDYVCHPVLASVIL	RALGAPB	551	Q86X10
IVECNSHVKEPRYLL	ZNFX1	536	Q9P2E3
EHVLCSPLAPRYVVE	ZDHHC8	241	Q9ULC8
VQYPLEVLCLHLIES	TTC37	236	Q6PGP7
NDVEVPLHLLRYVCL	USP34	201	Q70CQ2
VHELVDLIPEYEIAC	TYW1	631	Q9NV66
YEVVRPLVSLLHLNC	UNC45A	731	Q9H3U1
IRQVIHLILECYADL	GEMIN4	476	P57678
LEHYRRTHCVVPELI	MYBPC3	1116	Q14896