Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	IgC2-like_lig-bd	IL12RB2 CSF3R	2.16e-05	4	36	2	IPR010457
Domain	Lep_receptor_Ig	IL12RB2 CSF3R	2.16e-05	4	36	2	PF06328
Domain	Hematopoietin_rcpt_Gp130_CS	IL12RB2 CSF3R	7.54e-05	7	36	2	IPR003529
Domain	HEMATOPO_REC_L_F2	IL12RB2 CSF3R	1.00e-04	8	36	2	PS01353
Domain	C2_dom	C2CD6 OTOF ITSN2 SYNGAP1	2.71e-04	164	36	4	IPR000008
Domain	C2	OTOF ITSN2 SYNGAP1	2.03e-03	131	36	3	PF00168
Domain	C2	OTOF ITSN2 SYNGAP1	2.31e-03	137	36	3	SM00239
Domain	C2	OTOF ITSN2 SYNGAP1	2.56e-03	142	36	3	PS50004
Domain	-	OTOF ITSN2 SYNGAP1	2.87e-03	148	36	3	2.60.40.150
Domain	fn3	IL12RB2 CSF3R MYBPC2	3.71e-03	162	36	3	PF00041
Domain	FN3	IL12RB2 CSF3R MYBPC2	5.37e-03	185	36	3	SM00060
Domain	FN3	IL12RB2 CSF3R MYBPC2	6.57e-03	199	36	3	PS50853
Domain	FN3_dom	IL12RB2 CSF3R MYBPC2	7.52e-03	209	36	3	IPR003961
Domain	PHD	KDM5A BAZ2B	9.18e-03	75	36	2	PF00628
Domain	PH	RAPH1 ITSN2 SYNGAP1	9.64e-03	229	36	3	PF00169
Domain	Znf_PHD-finger	KDM5A BAZ2B	1.01e-02	79	36	2	IPR019787
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CCP110 SSH2 KIAA1191 RAPH1 MAP2 KDM5A VCPIP1	2.48e-05	861	36	7	36931259
Pubmed	p53 regulates neural stem cell proliferation and differentiation via BMP-Smad1 signaling and Id1.	MAP2 SMAD1	3.73e-05	9	36	2	23199293
Pubmed	A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2.	C2CD6 RAPH1	8.07e-05	13	36	2	11586298
Pubmed	Helios modulates the maturation of a CA1 neuronal subpopulation required for spatial memory formation.	MAP2 SYNGAP1	9.41e-05	14	36	2	31712124
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	CCP110 PCARE PDE3A OTOF	9.93e-05	234	36	4	36243803
Pubmed	FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells.	CAT MAP2	3.08e-04	25	36	2	28069738
Pubmed	D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function.	COL4A2 CAT	4.75e-04	31	36	2	22925884
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	SETD1B KDM5A BAZ2B	5.78e-04	157	36	3	30186101
Pubmed	BMP/SMAD Pathway Promotes Neurogenesis of Midbrain Dopaminergic Neurons In Vivo and in Human Induced Pluripotent and Neural Stem Cells.	MAP2 SMAD1	7.15e-04	38	36	2	29321139
Pubmed	Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly.	COL4A2 SMAD1	7.93e-04	40	36	2	27068110
Cytoband	Ensembl 112 genes in cytogenetic band chr2p23	PCARE OTOF ITSN2	2.21e-04	149	36	3	chr2p23
Cytoband	Ensembl 112 genes in cytogenetic band chr1p32	C1orf185 C1orf87	6.62e-03	155	36	2	chr1p32
Cytoband	Ensembl 112 genes in cytogenetic band chr2q33	C2CD6 RAPH1	1.13e-02	205	36	2	chr2q33
GeneFamily	Fibronectin type III domain containing	IL12RB2 CSF3R MYBPC2	8.05e-04	160	21	3	555
GeneFamily	PHD finger proteins	KDM5A BAZ2B	4.84e-03	90	21	2	88
Disease	glomerulonephritis (biomarker_via_orthology)	MS4A1 SMAD1	2.71e-04	20	36	2	DOID:2921 (biomarker_via_orthology)
Disease	monocyte count	COL4A2 ARHGAP30 SSH2 NCLN CSF3R BAZ2B ITSN2	9.42e-04	1320	36	7	EFO_0005091
Disease	major depressive episode	SETD1B BAZ2B	1.51e-03	47	36	2	EFO_0007634
Disease	renal agenesis, unilateral	POLR1G KDM5A	2.53e-03	61	36	2	MONDO_0019636
Disease	Major Depressive Disorder	CAT RAPH1 MAP2	3.22e-03	243	36	3	C1269683
Disease	serum alanine aminotransferase measurement, response to combination chemotherapy	POLR1G RAPH1	3.41e-03	71	36	2	EFO_0004735, EFO_0007965

Protein segments in the cluster

Peptide	Gene	Start	Entry
MMDISAPFFRDPPAP	C4orf33	31	Q8N1A6
PSNMPPGIEASPDKM	CAT	336	P04040
AKMPPESEVMTPKPN	BAZ2B	1476	Q9UIF8
PMPSLGEPLMEKVFS	C1orf185	166	Q5T7R7
APLPMMPVAEDEIKP	COL4A2	1571	P08572
TFPAEPMKGPIAMQS	MS4A1	11	P11836
APPMEPEVPEMSQSK	C1orf87	406	Q8N0U7
AEPTATMDDMALPPP	RAPH1	1191	Q70E73
PIMKQPPMFSPLISA	ITSN2	101	Q9NZM3
EKGTPPDMPVFTEQM	NCLN	431	Q969V3
KPIPFEPYISMDAMP	NIPAL3	326	Q6P499
KDMMHSASSPPPPRA	IL12RB2	741	Q99665
PSMFMNLAPPPERTD	C2CD6	261	Q53TS8
PETMMFLDKPILAPE	PDE3A	661	Q14432
DPAALKPPKMDIPVM	KIAA1191	266	Q96A73
PPPSFIMSYKLPMED	KDM5A	1671	P29375
PTSELMMKFFPSLKP	CENPJ	861	Q9HC77
SPPMAPTLFPMESKS	IFITM10	96	A6NMD0
YAKLPSPEPSMSPKM	CCP110	361	O43303
KLEPPMLRTMDPSPE	CSF3R	226	Q99062
FPMDMPAPGTPLDIS	OTOF	1711	Q9HC10
PPPPMEVLMDKSFAS	PCARE	831	A6NGG8
PPKPQFAKMPSAMCS	ARHGAP30	941	Q7Z6I6
AMEPVEPEMKPLESP	POLR1G	346	O15446
FIPPGASEELMPLMP	SPPL2C	616	Q8IUH8
MPSAPITSADCPKPM	SETD1B	646	Q9UPS6
YQMPTPDPLVPSKPM	MED13	561	Q9UHV7
PMDTNMMAPPLPSEI	SMAD1	241	Q15797
AIPEMPMFEIPSPDF	TDRKH	286	Q9Y2W6
LPMEELTSPLKDPPM	SSH2	611	Q76I76
MDMARLPSPTKEKPP	SYNGAP1	781	Q96PV0
MMAPQEAVPAEPSPK	ZNF574	101	Q6ZN55
KDMMKPLAPAFLSSP	ZNF385B	406	Q569K4
FPPKELMPPQAGMEK	VCPIP1	821	Q96JH7
PDKMAEAPPSEAMTL	MAP2	376	P11137
HKPLPRATMASDPMP	VWA5B1	666	Q5TIE3
MNTKPFMPIAPTSEP	MYBPC2	726	Q14324