Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-8 ERVK-19 ERVK-7 ERVK-10	1.54e-06	37	46	4	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-8 ERVK-19 ERVK-7 ERVK-10	1.72e-06	38	46	4	GO:0070001
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-8 ERVK-7 ERVK-10	1.86e-06	11	46	3	GO:0004523
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-8 ERVK-7 ERVK-10	4.09e-06	14	46	3	GO:0003964
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-8 ERVK-7 ERVK-10	1.48e-05	21	46	3	GO:0035613
GeneOntologyMolecularFunction	phosphodiesterase I activity	ENPP1 ENPP3	5.17e-05	5	46	2	GO:0004528
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-8 ERVK-7 ERVK-10	8.42e-05	37	46	3	GO:0016891
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-8 ERVK-7 ERVK-10	9.12e-05	38	46	3	GO:0034061
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-8 ERVK-7 ERVK-10	1.62e-04	46	46	3	GO:0016893
GeneOntologyMolecularFunction	nuclease activity	ERVK-8 ERVK-7 ERVK-10 ENPP1 ENPP3	1.85e-04	231	46	5	GO:0004518
GeneOntologyMolecularFunction	nucleoside triphosphate diphosphatase activity	ENPP1 ENPP3	2.31e-04	10	46	2	GO:0047429
GeneOntologyMolecularFunction	nucleotidyltransferase activity	ERVK-8 ERVK-7 ERVK-10 PARP15	4.11e-04	152	46	4	GO:0016779
GeneOntologyMolecularFunction	hydrolase activity, acting on ester bonds	ERVK-8 ERVK-7 ERVK-10 PNPLA1 PGAP6 ENPP1 ENPP3 INPP5K	4.59e-04	807	46	8	GO:0016788
GeneOntologyMolecularFunction	RNA endonuclease activity	ERVK-8 ERVK-7 ERVK-10	8.00e-04	79	46	3	GO:0004521
GeneOntologyMolecularFunction	zinc ion binding	ERVK-8 ERVK-19 ERVK-7 ERVK-10 ENPP1 ENPP3 TAB3 AGTPBP1	8.79e-04	891	46	8	GO:0008270
GeneOntologyMolecularFunction	polysaccharide binding	ENPP1 HLA-DRB5	2.31e-03	31	46	2	GO:0030247
GeneOntologyMolecularFunction	endopeptidase activity	ERVK-8 ERVK-19 ERVK-7 ERVK-10 ADAM20	3.00e-03	430	46	5	GO:0004175
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	ERVK-8 ERVK-7 MSH3 ERVK-10	3.07e-03	262	46	4	GO:0140097
GeneOntologyMolecularFunction	G protein-coupled peptide receptor activity	QRFPR MRGPRX1 INPP5K	3.56e-03	133	46	3	GO:0008528
GeneOntologyMolecularFunction	peptidase activity	ERVK-8 ERVK-19 ERVK-7 ERVK-10 ADAM20 AGTPBP1	3.71e-03	654	46	6	GO:0008233
GeneOntologyMolecularFunction	RNA nuclease activity	ERVK-8 ERVK-7 ERVK-10	3.79e-03	136	46	3	GO:0004540
GeneOntologyMolecularFunction	endonuclease activity	ERVK-8 ERVK-7 ERVK-10	3.79e-03	136	46	3	GO:0004519
GeneOntologyMolecularFunction	peptide receptor activity	QRFPR MRGPRX1 INPP5K	4.11e-03	140	46	3	GO:0001653
GeneOntologyMolecularFunction	transition metal ion binding	ERVK-8 ERVK-19 ERVK-7 ERVK-10 ENPP1 ENPP3 TAB3 AGTPBP1	5.33e-03	1189	46	8	GO:0046914
GeneOntologyMolecularFunction	peptide binding	QRFPR GRIN1 MRGPRX1 HLA-DRB5	6.09e-03	318	46	4	GO:0042277
GeneOntologyMolecularFunction	neuropeptide receptor activity	QRFPR MRGPRX1	6.64e-03	53	46	2	GO:0008188
GeneOntologyBiologicalProcess	DNA integration	ERVK-8 ERVK-7 ERVK-10	2.73e-06	13	45	3	GO:0015074
GeneOntologyBiologicalProcess	inorganic diphosphate transport	ENPP1 ENPP3	4.63e-05	5	45	2	GO:0030505
GeneOntologyBiologicalProcess	regulation of D-glucose transmembrane transport	C3 PRKAG2 ENPP1 INPP5K	8.05e-05	105	45	4	GO:0010827
GeneOntologyBiologicalProcess	DNA synthesis involved in DNA repair	ERVK-8 ERVK-7 ERVK-10	1.57e-04	48	45	3	GO:0000731
GeneOntologyBiologicalProcess	protein poly-ADP-ribosylation	ENPP1 PARP15	2.53e-04	11	45	2	GO:0070212
GeneOntologyBiologicalProcess	D-glucose transmembrane transport	C3 PRKAG2 ENPP1 INPP5K	3.02e-04	148	45	4	GO:1904659
GeneOntologyBiologicalProcess	negative regulation of glycogen biosynthetic process	ENPP1 INPP5K	3.03e-04	12	45	2	GO:0045719
GeneOntologyBiologicalProcess	nucleoside triphosphate catabolic process	ENPP1 ENPP3	3.03e-04	12	45	2	GO:0009143
GeneOntologyBiologicalProcess	hexose transmembrane transport	C3 PRKAG2 ENPP1 INPP5K	3.26e-04	151	45	4	GO:0008645
GeneOntologyBiologicalProcess	monosaccharide transmembrane transport	C3 PRKAG2 ENPP1 INPP5K	3.51e-04	154	45	4	GO:0015749
Domain	NUC	ENPP1 ENPP3	7.36e-05	6	42	2	SM00477
Domain	-	ENPP1 ENPP3	7.36e-05	6	42	2	3.40.570.10
Domain	Endonuclease_NS	ENPP1 ENPP3	7.36e-05	6	42	2	PF01223
Domain	Endonuclease_NS	ENPP1 ENPP3	7.36e-05	6	42	2	SM00892
Domain	Extracellular_endonuc_su_A	ENPP1 ENPP3	7.36e-05	6	42	2	IPR020821
Domain	DNA/RNA_non-sp_Endonuclease	ENPP1 ENPP3	7.36e-05	6	42	2	IPR001604
Domain	E-NPP	ENPP1 ENPP3	1.03e-04	7	42	2	IPR024873
Domain	Somatomedin_B	ENPP1 ENPP3	1.37e-04	8	42	2	PF01033
Domain	SO	ENPP1 ENPP3	1.76e-04	9	42	2	SM00201
Domain	Somatomedin_B_dom	ENPP1 ENPP3	2.20e-04	10	42	2	IPR001212
Domain	SMB_1	ENPP1 ENPP3	2.20e-04	10	42	2	PS00524
Domain	SMB_2	ENPP1 ENPP3	2.20e-04	10	42	2	PS50958
Domain	Phosphodiest	ENPP1 ENPP3	2.20e-04	10	42	2	PF01663
Domain	Phosphodiest/P_Trfase	ENPP1 ENPP3	2.20e-04	10	42	2	IPR002591
Domain	Alkaline_phosphatase_core	ENPP1 ENPP3	2.20e-03	31	42	2	IPR017850
Domain	Alkaline_Pase-like_a/b/a	ENPP1 ENPP3	2.20e-03	31	42	2	IPR017849
Domain	-	ENPP1 ENPP3	2.20e-03	31	42	2	3.40.720.10
Domain	HEAT	UTP20 CAND1	5.22e-03	48	42	2	PF02985
Domain	zf-RING_2	RNF38 RNF44	6.10e-03	52	42	2	PF13639
Domain	HEAT	UTP20 CAND1	7.54e-03	58	42	2	IPR000357
Domain	HEAT_REPEAT	UTP20 CAND1	1.08e-02	70	42	2	PS50077
Pathway	REACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_INTERLEUKIN_SIGNALING	LIFR ELF1	4.36e-05	5	30	2	M27800
Pubmed	Genomic structure and promoter analysis of the ecto-phosphodiesterase I gene (PDNP3) expressed in glial cells.	ENPP1 ENPP3	1.71e-06	2	46	2	10524196
Pubmed	Diadenosine 5',5''-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors.	ENPP1 ENPP3	1.71e-06	2	46	2	21090681
Pubmed	Identification of hydrolytically stable and selective P2Y(1) receptor agonists.	ENPP1 ENPP3	1.71e-06	2	46	2	18760862
Pubmed	Ectonucleotide pyrophosphatase/phosphodiesterase activity in Neuro-2a neuroblastoma cells: changes in expression associated with neuronal differentiation.	ENPP1 ENPP3	1.71e-06	2	46	2	24947519
Pubmed	Molecular cloning and chromosomal localization of PD-Ibeta (PDNP3), a new member of the human phosphodiesterase I genes.	ENPP1 ENPP3	1.71e-06	2	46	2	9344668
Pubmed	Expression and localization of ecto-nucleotide pyrophosphatase/phosphodiesterase I-1 (E-NPP1/PC-1) and -3 (E-NPP3/CD203c/PD-Ibeta/B10/gp130(RB13-6)) in inflammatory and neoplastic bile duct diseases.	ENPP1 ENPP3	1.71e-06	2	46	2	15072822
Pubmed	Differential mechanisms of inorganic pyrophosphate production by plasma cell membrane glycoprotein-1 and B10 in chondrocytes.	ENPP1 ENPP3	5.13e-06	3	46	2	10513816
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-8 ERVK-19 ERVK-7 ERVK-10	7.48e-06	94	46	4	21542922
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-19 ERVK-10	1.03e-05	4	46	2	7983737
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-7 ERVK-10	1.03e-05	4	46	2	10469592
Pubmed	Extracellular pyrophosphate metabolism and calcification in vascular smooth muscle.	ENPP1 ENPP3	1.71e-05	5	46	2	21490328
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-19 ERVK-7	1.71e-05	5	46	2	12629516
Pubmed	The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1.	RNF38 RNF44	9.34e-05	11	46	2	28536267
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-8 ERVK-19	1.12e-04	12	46	2	14557543
Pubmed	Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3.	VPS53 INPP5K	2.88e-04	19	46	2	12621583
Pubmed	Global analysis of genes differentially expressed in branching and non-branching regions of the mouse embryonic lung.	NFIX TAB3	3.54e-04	21	46	2	15328023
Pubmed	Maternal hypervitaminosis D reduces fetal bone mass and mineral acquisition and leads to neonatal lethality.	ENPP1 ENPP3	3.54e-04	21	46	2	23895994
Pubmed	Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons.	PCDH11X NEGR1	5.88e-04	27	46	2	24496616
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	DCBLD1 LIFR UTP20 CACHD1 CACYBP NEGR1 ENPP1	9.49e-04	1201	46	7	35696571
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	SZT2 VPS53 AGTPBP1	9.83e-04	147	46	3	29576527
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	LIFR B3GAT1 ENPP3	1.32e-02	394	23	3	471
GeneFamily	Fibronectin type III domain containing	LIFR MYOM2	1.74e-02	160	23	2	555
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	MYOM2 NEGR1	1.76e-02	161	23	2	593
ToppCell	Sepsis-URO-Myeloid-cDC1\|URO / Disease, condition lineage and cell class	CACYBP NEGR1 ENPP1 ENPP3 HLA-DRB5	1.23e-06	200	42	5	c5ca81218be40b30e2f9252c1a004cb95d988447
Drug	isodApdC	ENPP1 ENPP3	3.48e-06	2	43	2	CID000477021
Drug	pinicolic acid	ENPP1 ENPP3	3.48e-06	2	43	2	CID005320604
Drug	5-iodoindoxyl-3-phenylphosphonate	ENPP1 ENPP3	3.48e-06	2	43	2	CID000126064
Drug	RI-64	ENPP1 ENPP3	1.04e-05	3	43	2	CID000065758
Drug	4mupt	ENPP1 ENPP3	1.04e-05	3	43	2	CID000196156
Drug	phenylphosphonic dichloride	ENPP1 ENPP3	1.04e-05	3	43	2	CID000069990
Drug	quinovic acid	ENPP1 ENPP3	1.04e-05	3	43	2	CID000120678
Drug	lysinoalanine	C3 ENPP1 ENPP3	1.58e-05	26	43	3	CID000029269
Drug	benzoylsalireposide	ENPP1 ENPP3	2.09e-05	4	43	2	CID000639684
Drug	hebucol	ENPP1 ENPP3	2.09e-05	4	43	2	CID000072065
Drug	tartryl diazide	C3 MYOM2	3.47e-05	5	43	2	CID000193925
Drug	dMPA (r	ENPP1 ENPP3	3.47e-05	5	43	2	CID000078501
Drug	8-acetyl-2-(dipropylamino)tetralin	ENPP1 ENPP3	3.47e-05	5	43	2	CID000132276
Drug	3,5-heptanedione	ENPP1 ENPP3	3.47e-05	5	43	2	CID000081923
Drug	streptomycin 6-phosphate	ENPP1 ENPP3	3.47e-05	5	43	2	CID011953794
Drug	saterinone	ENPP1 ENPP3	5.20e-05	6	43	2	CID000065874
Drug	diadenosine diphosphate	ENPP1 ENPP3	5.20e-05	6	43	2	CID000188326
Drug	4-methylumbelliferyl phenylphosphonate	ENPP1 ENPP3	5.20e-05	6	43	2	CID000134928
Drug	NSC343256	ENPP1 ENPP3	5.20e-05	6	43	2	CID000335091
Drug	AC1L6XCD	ENPP1 ENPP3	5.20e-05	6	43	2	CID000325952
Drug	m-aminobenzamidine	ENPP1 ENPP3	7.27e-05	7	43	2	CID000197789
Drug	1-dodecanoyllysolecithin	ENPP1 ENPP3	7.27e-05	7	43	2	CID000460605
Drug	fluocortolone	C3 POF1B	7.27e-05	7	43	2	CID000009053
Drug	boric acid gel	ENPP1 ENPP3	9.69e-05	8	43	2	CID003016474
Drug	11-keto-beta-boswellic acid	ENPP1 ENPP3	9.69e-05	8	43	2	CID006918114
Drug	acronycine	C3 ENPP1	9.69e-05	8	43	2	CID000345512
Drug	auromomycin	ENPP1 ENPP3	9.69e-05	8	43	2	CID005748693
Drug	AC1NBVLZ	ENPP1 ENPP3	9.69e-05	8	43	2	CID004474584
Drug	cadeguomycin	ENPP1 ENPP3	1.24e-04	9	43	2	CID000133738
Drug	ddUMP	ENPP1 ENPP3	1.24e-04	9	43	2	CID003081662
Drug	chartreusin	ENPP1 ENPP3	1.24e-04	9	43	2	CID005281394
Drug	sodium lauryl sarcosinate	ENPP1 ENPP3	1.24e-04	9	43	2	CID000061426
Drug	taurodehydrocholate	ENPP1 ENPP3	1.24e-04	9	43	2	CID000121933
Drug	NSC285223	ENPP1 ENPP3	1.55e-04	10	43	2	CID000323607
Drug	2-(p-n-butylanilino)-2'-deoxyadenosine	ENPP1 ENPP3	1.55e-04	10	43	2	CID003062886
Drug	guanidinium-phosphate	ENPP1 ENPP3	1.90e-04	11	43	2	CID000160593
Drug	diethyl azodicarboxylate	ENPP1 ENPP3	1.90e-04	11	43	2	CID000220568
Drug	AC1L3ULO	ENPP1 ENPP3	1.90e-04	11	43	2	CID000095563
Drug	1,8-diaminooctane	ENPP1 ENPP3	2.27e-04	12	43	2	CID000024249
Drug	ethyl gallate	ENPP1 ENPP3	2.27e-04	12	43	2	CID000013250
Drug	BuAdATP	ENPP1 ENPP3	2.27e-04	12	43	2	CID000127308
Drug	phenylphosphonic acid	ENPP1 ENPP3	2.27e-04	12	43	2	CID000015295
Drug	AC1L2SH7	ENPP1 ENPP3	2.68e-04	13	43	2	CID000102258
Drug	PdNP	ENPP1 ENPP3	2.68e-04	13	43	2	CID000151930
Drug	glycerol-3-phosphocholine	LIFR C3 ENPP1 ENPP3	3.08e-04	172	43	4	CID000000823
Drug	tetracene	ENPP1 ENPP3	3.13e-04	14	43	2	CID000007080
Drug	epsilon NAD	ENPP1 ENPP3	3.13e-04	14	43	2	CID000170119
Drug	ddUrd	ENPP1 ENPP3	3.13e-04	14	43	2	CID000065161
Drug	pyridin-3-ol	ENPP1 ENPP3	3.13e-04	14	43	2	CID000007971
Drug	Probestin	ENPP1 ENPP3	3.13e-04	14	43	2	CID000130013
Drug	NSC 208734	MYOM2 ENPP1 ENPP3	3.14e-04	70	43	3	CID000002008
Drug	cytidine diphosphate-glucose	ENPP1 ENPP3	3.60e-04	15	43	2	CID000000292
Drug	Nppp	ENPP1 ENPP3	3.60e-04	15	43	2	CID003080789
Drug	alpha-amyrin	ENPP1 ENPP3	4.11e-04	16	43	2	CID000073170
Drug	Ret-P-Man	ENPP1 ENPP3	4.11e-04	16	43	2	CID006438377
Drug	AC1L1GZ2	ENPP1 ENPP3	4.11e-04	16	43	2	CID000003905
Drug	hydroxymethyltrioxsalen	ENPP1 ENPP3	4.11e-04	16	43	2	CID000104953
Drug	dG-C8-PhIP	ENPP1 ENPP3	4.11e-04	16	43	2	CID000132509
Drug	Mepenzolate bromide [76-90-4]; Down 200; 9.6uM; PC3; HT_HG-U133A	UTP20 ELF1 MSH3 NFIX	4.41e-04	189	43	4	4304_DN
Drug	Amp-NH2	ENPP1 ENPP3	4.65e-04	17	43	2	CID000440142
Disease	response to angiotensin receptor blocker	MACC1 PRKAG2	8.39e-04	30	42	2	EFO_0010735
Disease	blood barium measurement	UTP20 NEGR1	1.08e-03	34	42	2	EFO_0021528
Disease	Developmental delay (disorder)	SZT2 VPS53	1.28e-03	37	42	2	C0424605

Protein segments in the cluster

Peptide	Gene	Start	Entry
IHVVTPTYSRPVQKA	B3GAT1	86	Q9P2W7
PTQVTKQHTFPLESY	PRKAG2	166	Q9UGJ0
SPYPTQLFRTVHVVQ	ELF1	376	P32519
VEVPTVSPISRFTYH	ERVK-19	181	O71037
VEVPTVSPISRFTYH	ERVK-8	181	Q902F8
YFTSPEVVIPLKVIS	ADAM20	36	O43506
PIYVSTVRPQSKHIV	CACHD1	216	Q5VU97
IPIVTSPYQIHFTKT	C3	346	P01024
IKSSFHFQLPVIPVT	AGTPBP1	336	Q9UPW5
TSPVHQKIYTTFILV	QRFPR	206	Q96P65
YIPHPFLVVSVTLTS	RIC1	636	Q4ADV7
VKSLTLFVTHYPPVC	MSH3	1001	P20585
TLTRVQPVFHFKPTT	C20orf96	56	Q9NUD7
PITSPLQEVHFLVYT	PARP15	236	Q460N3
IIQQSSPYFTHPTIR	NFIX	376	Q14938
PKVTVYPARTQTLQH	HLA-DRB5	126	Q30154
VHLTVQVPPKIYDIS	NEGR1	131	Q7Z3B1
CPKEVYPHVSTIINI	CAND1	286	Q86VP6
FVKIYITLTGVHQVP	CACYBP	86	Q9HB71
PLVHVKETVSKPYVT	PNPLA1	476	Q8N8W4
VYPTKTFPNHYSIVT	ENPP1	251	P22413
PQTLLSHPSYLKVFV	PGAP6	201	Q9HCN3
YPVTTFEVPVSVHTR	PCDH11X	996	Q9BZA7
LHSPTVKLTTYPQTT	POF1B	121	Q8WVV4
VEVPTVSPISRFTYH	ERVK-7	941	P63135
ITIIHQVKANYFPSP	BCLAF3	476	A2AJT9
NTDVPIPTHYFVVLT	ENPP3	771	O14638
HLPYIQILSTKSTPT	INPP5K	106	Q9BT40
GPKYIHPSFTVVLTV	MACC1	376	Q6ZN28
VEVPTVSPISRFTYH	HERVK_113	181	Q902F9
TYPNHTVCEKTITVP	DCBLD1	61	Q8N8Z6
NITEKVYPHTPTSFK	LIFR	426	P42702
VVQYILFPPHSTSTK	SZT2	866	Q5T011
PHVPAILQYLSKTTI	UTP20	1301	O75691
VPVSYTVTTVAPHGI	RNF38	196	Q9H0F5
HIPRYSTNPITVTVS	TAB3	186	Q8N5C8
LVAIPVSIFYSVPHQ	KYAT1	376	Q16773
SFISIPHTISKILYP	MRGPRX1	86	Q96LB2
HQGPVPLSYTVTTVT	RNF44	101	Q7L0R7
PPQISSTYHKKTVYT	GEMIN5	461	Q8TEQ6
VEVPTVSPISRFTYH	ERVK-10	941	P10266
NHTLFPEKQIYTTSP	ZNF281	701	Q9Y2X9
PYVTSVILHIKQNVP	VPS53	636	Q5VIR6
KVTSISLPVAPAYHV	TRAPPC10	861	P48553
HKVLVVSVCPQSLPY	NARF	91	Q9UHQ1
VIKVQAALTVPSHPY	MYOM2	701	P54296
VTIHQEPFVYVKPTL	GRIN1	401	Q05586