Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionphosphatidylinositol 3-kinase inhibitor activity

WASH6P WASH3P WASHC1

7.71e-078493GO:0141039
GeneOntologyMolecularFunctionalpha-tubulin binding

WASH6P WASH3P WASHC1 TAOK1

7.94e-0652494GO:0043014
GeneOntologyMolecularFunctionphosphatidylinositol 3-kinase regulator activity

WASH6P WASH3P WASHC1

1.10e-0518493GO:0035014
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor binding

WASH6P WASH3P WASHC1

7.88e-0534493GO:0050750
GeneOntologyMolecularFunctiongamma-tubulin binding

WASH6P WASH3P WASHC1

1.10e-0438493GO:0043015
GeneOntologyMolecularFunctionlipoprotein particle receptor binding

WASH6P WASH3P WASHC1

1.19e-0439493GO:0070325
GeneOntologyMolecularFunctionstructural constituent of presynaptic active zone

PCLO BSN

1.64e-048492GO:0098882
GeneOntologyMolecularFunctiontranscription corepressor binding

PCLO PER1 BSN

4.10e-0459493GO:0001222
GeneOntologyMolecularFunctiontubulin binding

WASH6P WASH3P CEP295NL WASHC1 NAV3 TAOK1

6.00e-04428496GO:0015631
GeneOntologyMolecularFunctionkinase regulator activity

CDKN2A WASH6P WASH3P WASHC1 TAOK1

8.85e-04305495GO:0019207
GeneOntologyMolecularFunctiontranscription factor binding

CDKN2A HDAC9 PCLO KLF14 PER1 BSN EBF4

2.28e-03753497GO:0008134
GeneOntologyBiologicalProcesspositive regulation of cholesterol import

WASH6P WASH3P WASHC1

2.21e-076473GO:1904109
GeneOntologyBiologicalProcessregulation of cholesterol import

WASH6P WASH3P WASHC1

9.23e-079473GO:0060620
GeneOntologyBiologicalProcesspolar body extrusion after meiotic divisions

WASH6P WASH3P WASHC1

1.32e-0610473GO:0040038
GeneOntologyBiologicalProcessmeiotic cytokinesis

WASH6P WASH3P WASHC1

3.12e-0613473GO:0033206
GeneOntologyBiologicalProcessnegative regulation of protein localization to nucleolus

CDKN2A POLR1A

5.08e-062472GO:1904750
GeneOntologyBiologicalProcesscholesterol import

WASH6P WASH3P WASHC1

6.08e-0616473GO:0070508
GeneOntologyBiologicalProcessdendritic cell antigen processing and presentation

WASH6P WASH3P WASHC1

1.43e-0521473GO:0002468
GeneOntologyBiologicalProcesspresynapse to nucleus signaling pathway

PCLO BSN

1.52e-053472GO:0099526
GeneOntologyBiologicalProcessendosome to plasma membrane protein transport

WASH6P WASH3P WASHC1

2.17e-0524473GO:0099638
GeneOntologyBiologicalProcesspresynaptic signal transduction

PCLO BSN

3.04e-054472GO:0098928
GeneOntologyBiologicalProcessmeiotic spindle assembly

WASH6P WASH3P WASHC1

3.49e-0528473GO:0090306
GeneOntologyBiologicalProcessregulation of cholesterol transport

WASH6P WASH3P FURIN WASHC1

3.81e-0583474GO:0032374
GeneOntologyBiologicalProcessregulation of sterol transport

WASH6P WASH3P FURIN WASHC1

3.81e-0583474GO:0032371
GeneOntologyBiologicalProcesspositive regulation of protein localization to cell surface

WASH6P WASH3P WASHC1

3.89e-0529473GO:2000010
GeneOntologyBiologicalProcessregulation of Arp2/3 complex-mediated actin nucleation

WASH6P WASH3P WASHC1

4.77e-0531473GO:0034315
GeneOntologyBiologicalProcesspresynaptic active zone assembly

PCLO BSN

5.06e-055472GO:1904071
GeneOntologyBiologicalProcessregulation of lipid transport

WASH6P WASH3P FURIN WASHC1 REPIN1

5.31e-05179475GO:0032368
GeneOntologyBiologicalProcessmaintenance of presynaptic active zone structure

PCLO BSN

7.58e-056472GO:0048790
GeneOntologyBiologicalProcessmeiotic spindle organization

WASH6P WASH3P WASHC1

8.16e-0537473GO:0000212
GeneOntologyBiologicalProcessnegative regulation of microtubule depolymerization

NAV3 TAOK1 CKAP2

8.85e-0538473GO:0007026
GeneOntologyBiologicalProcessregulation of plasma lipoprotein particle levels

WASH6P WASH3P FURIN WASHC1

8.87e-05103474GO:0097006
GeneOntologyBiologicalProcesspositive regulation of sterol transport

WASH6P WASH3P WASHC1

1.03e-0440473GO:0032373
GeneOntologyBiologicalProcesspositive regulation of cholesterol transport

WASH6P WASH3P WASHC1

1.03e-0440473GO:0032376
GeneOntologyBiologicalProcessregulation of actin nucleation

WASH6P WASH3P WASHC1

1.11e-0441473GO:0051125
GeneOntologyBiologicalProcesslow-density lipoprotein particle clearance

WASH6P WASH3P WASHC1

1.11e-0441473GO:0034383
GeneOntologyBiologicalProcessregulation of microtubule depolymerization

NAV3 TAOK1 CKAP2

1.20e-0442473GO:0031114
GeneOntologyBiologicalProcessregulation of lipid localization

WASH6P WASH3P FURIN WASHC1 REPIN1

1.26e-04215475GO:1905952
GeneOntologyBiologicalProcessoocyte maturation

WASH6P WASH3P WASHC1

1.68e-0447473GO:0001556
GeneOntologyBiologicalProcessArp2/3 complex-mediated actin nucleation

WASH6P WASH3P WASHC1

1.68e-0447473GO:0034314
GeneOntologyBiologicalProcesscytoskeleton-dependent cytokinesis

WASH6P WASH3P WASHC1 CKAP2

1.99e-04127474GO:0061640
GeneOntologyBiologicalProcessnegative regulation of microtubule polymerization or depolymerization

NAV3 TAOK1 CKAP2

2.14e-0451473GO:0031111
GeneOntologyBiologicalProcessregulation of protein localization to cell surface

WASH6P WASH3P WASHC1

2.14e-0451473GO:2000008
GeneOntologyBiologicalProcesspresynaptic active zone organization

PCLO BSN

2.26e-0410472GO:1990709
GeneOntologyBiologicalProcessfemale meiotic nuclear division

WASH6P WASH3P WASHC1

2.27e-0452473GO:0007143
GeneOntologyBiologicalProcesscholesterol transport

WASH6P WASH3P FURIN WASHC1

2.45e-04134474GO:0030301
GeneOntologyBiologicalProcessregulation of protein localization to nucleolus

CDKN2A POLR1A

2.76e-0411472GO:1904749
GeneOntologyBiologicalProcesssterol transport

WASH6P WASH3P FURIN WASHC1

2.81e-04139474GO:0015918
GeneOntologyBiologicalProcessantigen processing and presentation

WASH6P WASH3P WASHC1 RELB

2.81e-04139474GO:0019882
GeneOntologyBiologicalProcesspresynapse assembly

NLGN4X PCLO BSN

3.46e-0460473GO:0099054
GeneOntologyBiologicalProcessregulation of cytokine production

HDAC9 ZBTB37 OSM SIGIRR FURIN NAV3 PER1 RELB EIF2AK3

3.96e-041010479GO:0001817
GeneOntologyBiologicalProcessplasma lipoprotein particle clearance

WASH6P WASH3P WASHC1

4.00e-0463473GO:0034381
GeneOntologyBiologicalProcessactin nucleation

WASH6P WASH3P WASHC1

4.39e-0465473GO:0045010
GeneOntologyBiologicalProcessregulation of supramolecular fiber organization

WASH6P WASH3P WASHC1 NAV3 TAOK1 CKAP2

4.55e-04438476GO:1902903
GeneOntologyBiologicalProcessmicrotubule depolymerization

NAV3 TAOK1 CKAP2

4.59e-0466473GO:0007019
GeneOntologyBiologicalProcesspresynapse organization

NLGN4X PCLO BSN

6.17e-0473473GO:0099172
GeneOntologyBiologicalProcesscytokine production

HDAC9 ZBTB37 OSM SIGIRR FURIN NAV3 PER1 RELB EIF2AK3

6.93e-041091479GO:0001816
GeneOntologyBiologicalProcessestablishment of protein localization to plasma membrane

WASH6P WASH3P WASHC1

6.94e-0476473GO:0061951
GeneOntologyBiologicalProcessregulation of organelle organization

CACNA1B WASH6P WASH3P OSM TBC1D4 CEP295NL WASHC1 NAV3 TAOK1 CKAP2

7.43e-0413424710GO:0033043
GeneOntologyBiologicalProcessprotein localization to cell surface

WASH6P WASH3P WASHC1

7.77e-0479473GO:0034394
GeneOntologyBiologicalProcessprotein localization to nucleolus

CDKN2A POLR1A

8.48e-0419472GO:1902570
GeneOntologyBiologicalProcessepigenetic regulation of gene expression

FAM47A HDAC9 MBD1 ZNFX1 BAHD1

8.99e-04330475GO:0040029
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

CDKN2A OSM ZNF142 ZNF219 KLF14 PER1 RELB CKAP2 IQCE EBF4

9.74e-0413904710GO:0045944
GeneOntologyBiologicalProcessnegative regulation of protein depolymerization

NAV3 TAOK1 CKAP2

1.10e-0389473GO:1901880
GeneOntologyBiologicalProcesssynaptic vesicle clustering

PCLO BSN

1.14e-0322472GO:0097091
GeneOntologyBiologicalProcessmicrotubule cytoskeleton organization

WASH6P WASH3P CEP295NL WASHC1 NAV3 TAOK1 CKAP2

1.14e-03720477GO:0000226
GeneOntologyBiologicalProcesscytokinesis

WASH6P WASH3P WASHC1 CKAP2

1.19e-03204474GO:0000910
GeneOntologyBiologicalProcesssupramolecular fiber organization

CDKN2A WASH6P WASH3P FURIN WASHC1 NAV3 TAOK1 CKAP2

1.31e-03957478GO:0097435
GeneOntologyBiologicalProcessendocytic recycling

WASH6P WASH3P WASHC1

1.33e-0395473GO:0032456
GeneOntologyBiologicalProcessvocalization behavior

NLGN4X BRINP1

1.36e-0324472GO:0071625
GeneOntologyBiologicalProcessoocyte development

WASH6P WASH3P WASHC1

1.49e-0399473GO:0048599
GeneOntologyBiologicalProcessnegative regulation of protein-containing complex disassembly

NAV3 TAOK1 CKAP2

1.54e-03100473GO:0043242
GeneOntologyBiologicalProcesspositive regulation of lipid transport

WASH6P WASH3P WASHC1

1.63e-03102473GO:0032370
GeneOntologyBiologicalProcessnegative regulation of multicellular organismal process

CDKN2A HDAC9 ATXN2 SIGIRR FURIN MBD1 NAV3 RELB BRINP1 EIF2AK3

1.63e-0314884710GO:0051241
GeneOntologyBiologicalProcessoocyte differentiation

WASH6P WASH3P WASHC1

1.67e-03103473GO:0009994
GeneOntologyBiologicalProcessregulation of protein ubiquitination

CDKN2A WASH6P WASH3P WASHC1

1.73e-03226474GO:0031396
GeneOntologyBiologicalProcessregulation of protein depolymerization

NAV3 TAOK1 CKAP2

1.77e-03105473GO:1901879
GeneOntologyBiologicalProcessendosome organization

WASH6P WASH3P WASHC1

1.82e-03106473GO:0007032
GeneOntologyBiologicalProcessregulation of protein polymerization

WASH6P WASH3P WASHC1 NAV3

1.87e-03231474GO:0032271
GeneOntologyBiologicalProcessregulation of microtubule polymerization or depolymerization

NAV3 TAOK1 CKAP2

1.91e-03108473GO:0031110
GeneOntologyBiologicalProcessregulation of cytoskeleton organization

WASH6P WASH3P WASHC1 NAV3 TAOK1 CKAP2

1.93e-03579476GO:0051493
GeneOntologyBiologicalProcessretrograde transport, endosome to Golgi

WASH6P WASH3P WASHC1

1.97e-03109473GO:0042147
GeneOntologyBiologicalProcessnegative regulation of autophagy

WASH6P WASH3P WASHC1

2.12e-03112473GO:0010507
GeneOntologyBiologicalProcessmeiotic nuclear division

WASH6P WASH3P OSM WASHC1

2.15e-03240474GO:0140013
GeneOntologyBiologicalProcessvesicle organization

CACNA1B WASH6P WASH3P TBC1D4 WASHC1

2.47e-03415475GO:0016050
GeneOntologyBiologicalProcessmicrotubule-based process

WASH6P WASH3P CEP295NL WASHC1 NAV3 TAOK1 CKAP2 BSN

2.47e-031058478GO:0007017
GeneOntologyBiologicalProcessnegative regulation of catabolic process

CDKN2A WASH6P WASH3P FURIN WASHC1

2.54e-03418475GO:0009895
GeneOntologyBiologicalProcessnegative regulation of organelle organization

OSM TBC1D4 NAV3 TAOK1 CKAP2

2.62e-03421475GO:0010639
GeneOntologyBiologicalProcesscellular component disassembly

CDKN2A FURIN WASHC1 NAV3 TAOK1 CKAP2

2.65e-03617476GO:0022411
GeneOntologyBiologicalProcessmeiotic chromosome segregation

WASH6P WASH3P WASHC1

2.71e-03122473GO:0045132
GeneOntologyBiologicalProcesspeptide biosynthetic process

FURIN EIF2AK3

2.72e-0334472GO:0043043
GeneOntologyBiologicalProcessregulation of vesicle fusion

CACNA1B TBC1D4

2.88e-0335472GO:0031338
GeneOntologyBiologicalProcessmulticellular organismal response to stress

CACNA1B OSM BRINP1

2.97e-03126473GO:0033555
GeneOntologyBiologicalProcessexocytosis

CACNA1B WASH6P WASH3P PCLO WASHC1

2.99e-03434475GO:0006887
GeneOntologyBiologicalProcesssynaptic vesicle cycle

CACNA1B NLGN4X PCLO BSN

3.04e-03264474GO:0099504
GeneOntologyCellularComponentWASH complex

WASH6P WASH3P WASHC1

5.40e-0615493GO:0071203
GeneOntologyCellularComponentBLOC-1 complex

WASH6P WASH3P WASHC1

9.63e-0618493GO:0031083
GeneOntologyCellularComponentexocyst

WASH6P WASH3P WASHC1

1.56e-0521493GO:0000145
GeneOntologyCellularComponentBLOC complex

WASH6P WASH3P WASHC1

2.07e-0523493GO:0031082
GeneOntologyCellularComponentinhibitory synapse

NLGN4X PCLO BSN

5.19e-0531493GO:0060077
GeneOntologyCellularComponentcytoskeleton of presynaptic active zone

PCLO BSN

1.49e-048492GO:0048788
GeneOntologyCellularComponentpresynaptic cytoskeleton

PCLO BSN

4.81e-0414492GO:0099569
GeneOntologyCellularComponentGABA-ergic synapse

GABRE NLGN4X PCLO BSN

5.88e-04164494GO:0098982
GeneOntologyCellularComponentvesicle tethering complex

WASH6P WASH3P WASHC1

6.44e-0472493GO:0099023
GeneOntologyCellularComponentcentriole

WASH3P CEP295NL WASHC1 SFI1

7.03e-04172494GO:0005814
GeneOntologyCellularComponenttrans-Golgi network

MMP24 ATXN2 PCLO FURIN BSN

7.32e-04306495GO:0005802
GeneOntologyCellularComponentpresynaptic active zone cytoplasmic component

PCLO BSN

1.32e-0323492GO:0098831
GeneOntologyCellularComponentcell cortex

WASH6P WASH3P PCLO WASHC1 BSN

1.72e-03371495GO:0005938
GeneOntologyCellularComponentexcitatory synapse

NLGN4X PCLO BSN

2.02e-03107493GO:0060076
GeneOntologyCellularComponentrecycling endosome membrane

WASH6P WASH3P WASHC1

2.31e-03112493GO:0055038
GeneOntologyCellularComponentGolgi-associated vesicle

PCLO FURIN BSN

2.42e-03114493GO:0005798
GeneOntologyCellularComponentribbon synapse

PCLO BSN

2.55e-0332492GO:0097470
GeneOntologyCellularComponentautophagosome

WASH6P WASH3P WASHC1

2.74e-03119493GO:0005776
GeneOntologyCellularComponentfilopodium

WASH6P WASH3P WASHC1

3.01e-03123493GO:0030175
GeneOntologyCellularComponentGolgi apparatus subcompartment

MMP24 ATXN2 PCLO FURIN BSN

3.70e-03443495GO:0098791
GeneOntologyCellularComponentpresynaptic active zone

CACNA1B PCLO BSN

4.41e-03141493GO:0048786
GeneOntologyCellularComponentcell cortex region

PCLO BSN

5.00e-0345492GO:0099738
GeneOntologyCellularComponentmicrotubule organizing center

WASH6P WASH3P CEP295NL WASHC1 RELB SFI1 CKAP2

5.32e-03919497GO:0005815
MousePhenoabnormal ectoplacental cavity morphology

WASH6P WASH3P WASHC1

7.60e-0615373MP:0011202
MousePhenoabnormal extraembryonic coelom morphology

WASH6P WASH3P WASHC1

1.89e-0520373MP:0011200
MousePhenoabnormal amniotic cavity morphology

WASH6P WASH3P WASHC1

3.77e-0525373MP:0011199
DomainZnf_piccolo

PCLO BSN

5.42e-062442IPR008899
Domainzf-piccolo

PCLO BSN

5.42e-062442PF05715
DomainWH2

WASHC1 WASH2P

1.45e-0324442PS51082
DomainIPT

RELB EBF4

1.83e-0327442SM00429
DomainTIG

RELB EBF4

2.42e-0331442PF01833
DomainIPT

RELB EBF4

2.57e-0332442IPR002909
DomainZnf_FYVE_PHD

TCF19 PCLO BSN

5.00e-03147443IPR011011
Domainzf-C2H2

ZBTB37 ZNF142 ZNF219 ZNF775 KLF14 REPIN1

5.42e-03693446PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZBTB37 ZNF142 ZNF219 ZNF775 KLF14 REPIN1

5.46e-03694446IPR013087
DomainZINC_FINGER_C2H2_2

ZBTB37 ZNF142 ZNF219 ZNF775 KLF14 REPIN1

9.21e-03775446PS50157
DomainZINC_FINGER_C2H2_1

ZBTB37 ZNF142 ZNF219 ZNF775 KLF14 REPIN1

9.32e-03777446PS00028
DomainZnf_C2H2-like

ZBTB37 ZNF142 ZNF219 ZNF775 KLF14 REPIN1

1.04e-02796446IPR015880
DomainZnf_C2H2

ZBTB37 ZNF142 ZNF219 ZNF775 KLF14 REPIN1

1.10e-02805446IPR007087
DomainZnF_C2H2

ZBTB37 ZNF142 ZNF219 ZNF775 KLF14 REPIN1

1.12e-02808446SM00355
Domain4_helix_cytokine-like_core

OSM ZNF142

1.32e-0274442IPR009079
Pubmed

Characterization of the murine orthologue of a novel human subtelomeric multigene family.

WASH6P WASH3P WASHC1 WASH2P

2.40e-11553411701968
Pubmed

Human subtelomeric WASH genes encode a new subclass of the WASP family.

WASH6P WASH3P WASHC1 WASH2P

7.19e-11653418159949
Pubmed

Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region.

WASH6P WASH3P WASHC1 WASH2P

3.35e-10853410655549
Pubmed

Changes in bile acid composition are correlated with reduced intestinal cholesterol uptake in intestine-specific WASH-deficient mice.

WASH6P WASH3P WASHC1

3.34e-09353338086439
Pubmed

WASH Regulates Glucose Homeostasis by Facilitating Glut2 Receptor Recycling in Pancreatic β-Cells.

WASH6P WASH3P WASHC1

3.34e-09353330425062
Pubmed

WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.

WASH6P WASH3P WASHC1

3.34e-09353325225459
Pubmed

WASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector function.

WASH6P WASH3P WASHC1

1.34e-08453323275443
Pubmed

Inactivation of Rho GTPases by Burkholderia cenocepacia Induces a WASH-Mediated Actin Polymerization that Delays Phagosome Maturation.

WASH6P WASH3P WASHC1

1.34e-08453332492429
Pubmed

The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance.

WASH6P WASH3P WASHC1

1.34e-08453331167970
Pubmed

Loss of MAGEL2 in Prader-Willi syndrome leads to decreased secretory granule and neuropeptide production.

WASH6P WASH3P WASHC1

1.34e-08453332879135
Pubmed

Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks.

WASH6P WASH3P WASHC1

1.34e-08453322718907
Pubmed

Dendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell priming.

WASH6P WASH3P WASHC1

1.34e-08453324886983
Pubmed

Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia.

WASH6P WASH3P WASHC1

3.33e-08553324344185
Pubmed

Functional characterization of Wiskott-Aldrich syndrome protein and scar homolog (WASH), a bi-modular nucleation-promoting factor able to interact with biogenesis of lysosome-related organelle subunit 2 (BLOS2) and gamma-tubulin.

WASH6P WASH3P WASHC1

3.33e-08553320308062
Pubmed

Diverse fates of paralogs following segmental duplication of telomeric genes.

WASH6P WASHC1 WASH2P FOXD4

3.44e-082253415233989
Pubmed

WASH complex regulates Arp2/3 complex for actin-based polar body extrusion in mouse oocytes.

WASH6P WASH3P WASHC1

6.66e-08653324998208
Pubmed

WASH maintains NKp46+ ILC3 cells by promoting AHR expression.

WASH6P WASH3P WASHC1

1.16e-07753328589939
Pubmed

The Proteome of BLOC-1 Genetic Defects Identifies the Arp2/3 Actin Polymerization Complex to Function Downstream of the Schizophrenia Susceptibility Factor Dysbindin at the Synapse.

WASH6P WASH3P WASHC1

1.86e-07853327927957
Pubmed

A FAM21-containing WASH complex regulates retromer-dependent sorting.

WASH6P WASH3P WASHC1

1.86e-07853319922874
Pubmed

RNF2 is recruited by WASH to ubiquitinate AMBRA1 leading to downregulation of autophagy.

WASH6P WASH3P WASHC1

2.79e-07953324980959
Pubmed

Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination.

WASH6P WASH3P WASHC1

3.98e-071053323452853
Pubmed

WASH inhibits autophagy through suppression of Beclin 1 ubiquitination.

WASH6P WASH3P WASHC1

3.98e-071053323974797
Pubmed

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL.

WASH6P WASH3P WASHC1

5.47e-071153326965651
Pubmed

The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex.

WASH6P WASH3P WASHC1

7.28e-071253319922875
Pubmed

Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour.

WASH6P WASH3P WASHC1

7.28e-071253327390154
Pubmed

Calcium channels link the muscle-derived synapse organizer laminin β2 to Bassoon and CAST/Erc2 to organize presynaptic active zones.

CACNA1B PCLO BSN

1.20e-061453321228161
Pubmed

Parkin mediates the ubiquitination of VPS35 and modulates retromer-dependent endosomal sorting.

WASH6P WASH3P WASHC1

1.50e-061553329893854
Pubmed

Bassoon and Piccolo maintain synapse integrity by regulating protein ubiquitination and degradation.

PCLO BSN

2.28e-06253223403927
Pubmed

Role of Bassoon and Piccolo in Assembly and Molecular Organization of the Active Zone.

PCLO BSN

2.28e-06253226793095
Pubmed

An unusual C(2)-domain in the active-zone protein piccolo: implications for Ca(2+) regulation of neurotransmitter release.

PCLO PER1

2.28e-06253211285225
Pubmed

Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis.

PCLO BSN

2.28e-06253220332206
Pubmed

Active zone density is conserved during synaptic growth but impaired in aged mice.

PCLO BSN

2.28e-06253221935939
Pubmed

WASH and the Arp2/3 complex regulate endosome shape and trafficking.

WASH3P WASHC1

2.28e-06253220175130
Pubmed

Dual-color STED microscopy reveals a sandwich structure of Bassoon and Piccolo in active zones of adult and aged mice.

PCLO BSN

2.28e-06253227321892
Pubmed

No symphony without bassoon and piccolo: changes in synaptic active zone proteins in Huntington's disease.

PCLO BSN

2.28e-06253232493491
Pubmed

RelB-induced expression of Cot, an MAP3K family member, rescues RANKL-induced osteoclastogenesis in alymphoplasia mice by promoting NF-κB2 processing by IKKα.

MAP3K8 RELB

2.28e-06253224488495
Pubmed

Synaptic activity controls localization and function of CtBP1 via binding to Bassoon and Piccolo.

PCLO BSN

2.28e-06253225652077
Pubmed

Genetic variants in DNA repair genes and the risk of cutaneous malignant melanoma in melanoma-prone families with/without CDKN2A mutations.

CDKN2A POLN

6.83e-06353221671477
Pubmed

Impact of Ataxin-2 knock out on circadian locomotor behavior and PER immunoreaction in the SCN of mice.

ATXN2 PER1

6.83e-06353227791392
Pubmed

Bisphenol A Induces Accelerated Cell Aging in Murine Endothelium.

CDKN2A EIF2AK3

6.83e-06353234680063
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

CACNA1B WASH6P WASH3P SPATS2L ATXN2 WASHC1 NAV3

7.60e-0647553731040226
Pubmed

NONO couples the circadian clock to the cell cycle.

CDKN2A PER1

2.27e-05553223267082
Pubmed

Genome wide SNP comparative analysis between EGFR and KRAS mutated NSCLC and characterization of two models of oncogenic cooperation in non-small cell lung carcinoma.

CDKN2A HDAC9

2.27e-05553218549475
Pubmed

A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1.

PCLO BSN

3.40e-05653219812333
Pubmed

Physical and functional interaction of the active zone proteins, CAST, RIM1, and Bassoon, in neurotransmitter release.

PCLO BSN

3.40e-05653214734538
Pubmed

Human BAHD1 promotes heterochromatic gene silencing.

MBD1 BAHD1

3.40e-05653219666599
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

ZBTB37 TBC1D4 MAP3K8 MBD1 PER1 RELB EIF2AK3 FOXD4

4.37e-0585753825609649
Pubmed

An atlas of combinatorial transcriptional regulation in mouse and man.

HDAC9 ZNF219 TCF19 POLR1A MBD1 PER1 RELB EBF4

5.14e-0587753820211142
Pubmed

New common variants affecting susceptibility to basal cell carcinoma.

CDKN2A KLF14

6.34e-05853219578363
Pubmed

Potential target genes of EMX2 include Odz/Ten-M and other gene families with implications for cortical patterning.

WASH6P WASH3P WASHC1

6.61e-055153316919471
Pubmed

Superresolution imaging of chemical synapses in the brain.

PCLO BSN

8.15e-05953221144999
Pubmed

Regulation of NF-κB by the p105-ABIN2-TPL2 complex and RelAp43 during rabies virus infection.

MAP3K8 RELB

1.02e-041053229084252
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

FAM47A MXRA5 ZNF775 TBC1D4 PCLO FAM186B IQCE

1.22e-0473653729676528
Pubmed

Multiple roles of integrin-α3 at the neuromuscular junction.

PCLO BSN

1.49e-041253228386022
Pubmed

Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma.

CDKN2A KLF14

2.05e-041453224403052
Pubmed

O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry.

PCLO BSN

2.05e-041453216452088
Pubmed

Long noncoding RNA PiHL regulates p53 protein stability through GRWD1/RPL11/MDM2 axis in colorectal cancer.

PCLO NAV3

2.36e-041553231903119
Pubmed

A directed protein interaction network for investigating intracellular signal transduction.

OSM ZNF219 ZNF775 TCF19 TAOK1 WASH2P BAHD1 GPRASP2

2.83e-04112453821900206
Pubmed

The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.

CDKN2A OSM CKAP2 EIF2AK3

4.03e-0422753426410627
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

ATXN2 RELB BSN FAM186B IQCE

4.97e-0443053535044719
Pubmed

p16 Protein and gigaxonin are associated with the ubiquitination of NFκB in cisplatin-induced senescence of cancer cells.

CDKN2A MAP3K8

5.16e-042253225331947
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

TBC1D4 PCLO SFI1

5.61e-041055339628581
Pubmed

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.

CACNA1B SPATS2L POLR1A PCLO GPRASP2

9.44e-0449653531343991
Pubmed

Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays.

CACNA1B HDAC9

1.03e-033153214684825
Pubmed

The synaptic vesicle cycle.

PCLO BSN

1.03e-033153215217342
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

TBC1D4 ZNFX1 BAHD1

1.04e-0313053312421765
Pubmed

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.

CDKN2A KLF14

1.24e-033453220581827
Pubmed

A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.

ATXN2 TAOK1

1.24e-033453224026423
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

FURIN PER1 RELB SFI1 REPIN1 BAHD1 IQCE

1.38e-03110553735748872
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

CDKN2A OSM ZNF219 MBD1 PER1 REPIN1 PSMG3-AS1

1.46e-03111653731753913
Cytoband9p24.3

WASHC1 FOXD4

1.18e-04145329p24.3
CytobandXp22.33

MXRA5 NLGN4X

3.86e-0425532Xp22.33
Cytoband7p22.3

PSMG3-AS1 IQCE

7.16e-04345327p22.3
Cytoband22q12.2

OSM SFI1

2.07e-035853222q12.2
Cytoband7q36.1

ZNF775 REPIN1

3.35e-03745327q36.1
GeneFamilyWiskott-Aldrich Syndrome protein family

WASH6P WASH3P WASHC1 WASH2P

1.65e-081633414
GeneFamilyZinc fingers|Zinc fingers PARP-type|Poly(ADP-ribose) polymerases

PCLO BSN

3.34e-041533226
GeneFamilyMitogen-activated protein kinase kinase kinases|RAF family

MAP3K8 TAOK1

8.70e-0424332654
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZBTB37 ZNF142 ZNF219 ZNF775 KLF14 REPIN1

1.70e-0371833628
ToppCell367C-Myeloid-Dendritic-cDC_activated|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

TBC1D4 PCLO RELB REPIN1 EBF4 FOXD4

5.97e-08177526a0ff337f11bdb11959ac71805ff94be6b4ec1083
ToppCell(3)_MNP-(3)_DC_activated|(3)_MNP / Lung cell shreds - cell class (v4) and cell subclass (v4)

MMP24 TBC1D4 RELB REPIN1 EBF4 FOXD4

9.36e-081915260353bf797c4ef237b9bb82460c173c7d03cb8883
ToppCellNS-moderate-d_0-4-Epithelial-Ionocyte|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MMP24 TBC1D4 NLGN4X NAV3 CKAP2

1.88e-06175525a1e0a15c69211d6db2edeb101476f0f6e08b90c8
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_10|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TBC1D4 RELB REPIN1 EBF4 FOXD4

2.16e-0618052532d871738a24071b70084a7e80148a516110c78b
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_10|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TBC1D4 RELB REPIN1 EBF4 FOXD4

2.16e-06180525067ca8a15228c7f3b3bc7aecbc9b1611ca05e176
ToppCell(3)_DC_activated|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

MMP24 TBC1D4 RELB REPIN1 FOXD4

2.75e-06189525e977838793fc0eb1499e81018e33e4ccb4a5f0c5
ToppCell367C-Myeloid-Dendritic-cDC_activated|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

TBC1D4 RELB REPIN1 EBF4 FOXD4

2.97e-06192525e44e37e5aeba8628556020d05e1606b28e2faa4f
ToppCelldroplet-Lung-30m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l14|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

OSM TBC1D4 POLN BSN

2.99e-051525240fda8980b10ce16179dea92301db74d728f41794
ToppCell356C-Myeloid-Dendritic-cDC_activated|356C / Donor, Lineage, Cell class and subclass (all cells)

TBC1D4 REPIN1 EBF4 FOXD4

4.31e-0516752443a9375fdbafd7450c553e4620e21537e08639dd
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_4|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

HDAC9 TBC1D4 SPATS2L POLN

4.42e-0516852463437b3c3a66f953eaed600965ab193f9cc49da2
ToppCell356C-Myeloid-Dendritic-cDC_activated|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

TBC1D4 REPIN1 EBF4 FOXD4

4.52e-0516952444d201361eb497222a4972a0e10bac1e05dcfd0a
ToppCellControl-Classical_Monocyte-cMono_4|Classical_Monocyte / Disease condition and Cell class

OSM MAP3K8 FURIN RELB

4.62e-051705249e328e1f904c77dcce8aee4df775d7f0ac725775
ToppCell367C-Myeloid-Dendritic-cDC_activated|367C / Donor, Lineage, Cell class and subclass (all cells)

TBC1D4 RELB REPIN1 FOXD4

4.95e-0517352494f99f7e7813d6e53e0bedf97087400b1bf00129
ToppCelldroplet-Lung-30m-Hematologic-myeloid-Basophil/Mast_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

OSM TBC1D4 POLN BSN

5.06e-05174524e9e4532a474b4b0938a50ff85c9508aca53cd3ae
ToppCelldroplet-Lung-nan-18m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDKN2A ZNF142 TBC1D4 RELB

5.29e-0517652424b2e94ee5defcefb64a1f2447a2cc71b015b0fd
ToppCellsystemic_lupus_erythematosus-managed|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

GABRE OSM MAP3K8 PER1

5.29e-05176524e406a05345461d23cba21c5444223c937143e96a
ToppCellT_cells-Tph_and_Tfh|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

TBC1D4 SPATS2L MAP3K8 FURIN

5.29e-0517652456c055488e34605d32562571a2fee621b47c9441
ToppCelldroplet-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CDKN2A ZNF142 TBC1D4 RELB

5.41e-05177524f360f7099570d248531897b96e0de282e58f59e9
ToppCellwk_15-18-Hematologic-Myeloid-aDC_1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

TBC1D4 RELB REPIN1 FOXD4

5.41e-05177524ccf5dc54780d6039a4d062dee88440c011ddc0a3
ToppCellBAL-Mild-Myeloid-Neutrophil-Neutrophil-Neu_3|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

OSM PER1 TAOK1

5.51e-05635231c8f4d173a6348cf5ea3d7d099b48dabc15d07ac
ToppCellBAL-Mild-Myeloid-Neutrophil-Neutrophil|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

OSM PER1 TAOK1

5.51e-05635239c108339b9d03a5f88de61c25e4ba920138245cc
ToppCellMild_COVID-19-Myeloid-Neutrophil|Mild_COVID-19 / Disease group,lineage and cell class (2021.01.30)

OSM PER1 TAOK1

5.51e-0563523de62e0692cda074dffb036c2d276ac33656c8a43
ToppCellBAL-Mild-Myeloid-Neutrophil|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

OSM PER1 TAOK1

5.51e-05635238874c58f3996f98323ca894647a25569727e3652
ToppCellBAL-Mild-Myeloid-Neutrophil-Neutrophil-Neu_3|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

OSM PER1 TAOK1

5.51e-056352363471d9ae567d3275561729048a4cb78407d28f6
ToppCellBAL-Mild-Myeloid-Neutrophil-Neutrophil|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

OSM PER1 TAOK1

5.51e-056352313aa61e3d54d7290df7ef982c70b2b4e9f6c7a32
ToppCellBAL-Mild-Myeloid-Neutrophil|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

OSM PER1 TAOK1

5.51e-0563523bc8a5e40d828110c650a4760eaf682dbfacd8b5b
ToppCellSubstantia_nigra-Neuronal|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CACNA1B MMP24 PCLO BSN

6.56e-051865243f889083fcffe516388e9b03a5e23af2010ced33
ToppCellPBMC-Mild-cDC_5|Mild / Compartment, Disease Groups and Clusters

OSM MAP3K8 FURIN PER1

6.69e-051875240afef5baf3752314dbfb024790347d5e51f9b84b
ToppCellMild-Myeloid-mDC-|Mild / Condition, Lineage, Cell class and cell subclass

HDAC9 RELB REPIN1 EBF4

7.41e-051925248520b3fdf4508ac66f7918da613abc928ab5832a
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_5|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

HDAC9 OSM SPATS2L MAP3K8

7.41e-05192524dfb9101622f7d2f2c392e850cff07becfc8c655e
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_5|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HDAC9 OSM SPATS2L MAP3K8

7.41e-05192524d39133cf1a20af6f2970188630fc3b27a4cfc9c5
ToppCellMild-Myeloid-mDC|Mild / Condition, Lineage, Cell class and cell subclass

HDAC9 RELB REPIN1 EBF4

7.41e-05192524da3952bd5c96242c15eb76678d0608ae2926a16e
ToppCellBAL-Severe-Myeloid-cDC-cDC-cDC_10|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TBC1D4 RELB REPIN1 EBF4

7.56e-05193524a2194012dfa0174c6160900625c44e0fd04c50e7
ToppCellBAL-Severe-Myeloid-cDC-cDC-cDC_10|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TBC1D4 RELB REPIN1 EBF4

7.56e-051935247426a30ed01e5c8376b3e0ebe0f1057cfee88340
ToppCellnormal_Pleural_Fluid-Myeloid_cells-Activated_DCs|normal_Pleural_Fluid / Location, Cell class and cell subclass

TBC1D4 RELB REPIN1 EBF4

7.72e-05194524219056d4ad256cda73208b8c570bbf689219df83
ToppCellnormal_Pleural_Fluid-Myeloid_cells-Activated_DCs|Myeloid_cells / Location, Cell class and cell subclass

TBC1D4 RELB REPIN1 EBF4

7.72e-0519452430f683725cb13ae32ef6846618801ec78e12397d
ToppCellHippocampus-Neuronal|Hippocampus / BrainAtlas - Mouse McCarroll V32

CACNA1B PCLO TAOK1 BSN

7.72e-051945248aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCell390C-Myeloid-Dendritic-cDC_activated|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

TBC1D4 RELB REPIN1 EBF4

7.87e-05195524ecf7d9856a5b507ec17c325c9a772dc5a184bc8e
ToppCellCOVID-19_Severe-cDC|COVID-19_Severe / disease group, cell group and cell class

HDAC9 OSM MAP3K8 PER1

7.87e-051955246419090b19de7b5d5140eaecf231860273da2c0d
ToppCellCOVID-19_Severe-cDC|World / disease group, cell group and cell class

HDAC9 SPATS2L MAP3K8 PER1

8.35e-05198524c452334249f047265ae89dcabe7de446d968cae6
ToppCellLPS-antiTNF-Myeloid-Monocytes,_Macrophages-Erythroid|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1B MMP24 CKAP2

6.33e-041445231b9e95e4f6e40042d3cf2f94c067f3a6b19428ea
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c14-MKI67-CCL5_h|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

C20orf203 CDKN2A ZNF775

6.33e-04144523bdd6d00b2d1c9dad989df82367a60e8be79de816
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

GABRE ZBTB37 IQCE

7.12e-04150523b6f1fc62d08199fed6156c7cd32f66d9926531b5
ToppCellPND28-Immune-Immune_Myeloid-DC-maDC|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CDKN2A TBC1D4 RELB

7.54e-04153523b03375c54aa701817c0fc2c3fef32b870169e697
ToppCellPND28-Immune-Immune_Myeloid-DC-maDC-maDC_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CDKN2A TBC1D4 RELB

7.54e-0415352318bd770a18e642581a6df144d47184c1ac383713
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_2|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TBC1D4 SPATS2L NAV3

7.69e-04154523b16f3139ce50e70a6a2377b1da7d7877b4000ea1
ToppCellPND28-Immune-Immune_Myeloid-Granulocytic-Basophil|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZNF219 ZNF775 TBC1D4

8.13e-041575238c42af7aa1f1b6f4fe2f8d00a8b4a800f121e804
ToppCellPND28-Immune-Immune_Myeloid-Granulocytic|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZNF219 ZNF775 TBC1D4

8.13e-04157523ee1be3c756b72fceac6b4ccb416dd4bd031a2193
ToppCellPND28-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZNF219 ZNF775 TBC1D4

8.13e-04157523008f938a338f43c3251dcac574f1b4f689926c71
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CDKN2A SIGIRR BSN

8.13e-041575236730b775308f45a2f3946016bdbb7f8e5b5efe49
ToppCellPND10-Immune-Immune_Myeloid-Granulocytic-Mast|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

OSM POLN BAHD1

8.58e-041605236393e3d5c5c8176c93aecd89b313bd054a00d474
ToppCellPND07-Immune-Immune_Myeloid-DC-maDC-maDC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CDKN2A TBC1D4 RELB

8.58e-0416052301f22cdb2a2f73776b7f91746e95c1850df94235
ToppCellPND10-Immune-Immune_Myeloid-Granulocytic-Mast-Mast_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

OSM POLN BAHD1

8.58e-041605232065938e944eb99478fd8132c2c03adeaee6d447
ToppCellPND07-Immune-Immune_Myeloid-DC-maDC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CDKN2A TBC1D4 RELB

8.58e-041605237db30647b596f0c419087e6fabb9b99dcd5bddd4
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P5-P5_1|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

CDKN2A TCF19 CKAP2

8.74e-041615230dd1401b4c990d49fccb702a9f9867590a58e203
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GABRE KLF14 NAV3

8.74e-04161523a006491c991e6a134be20ad75092a91f3b7c3c91
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P5-P5_1-Mitotic.MkI67_(Mitotic.MkI67)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

CDKN2A TCF19 CKAP2

8.74e-04161523b6a31c033edc74f23a20aab1f18e80cc83ffee4c
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P5|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

CDKN2A TCF19 CKAP2

8.74e-04161523efb811dda4d73107983a5f68302bdcf4f408d5b4
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_5|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

HDAC9 OSM PER1

8.74e-0416152378cc5bc488bc47726195a649946d414e6bfabf94
ToppCellGlobus_pallidus-Macroglia-POLYDENDROCYTE-P5-P5_1-Mitotic.MkI67_(Mitotic.MkI67)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

CDKN2A TCF19 CKAP2

8.74e-0416152328d5dbd20c9f8e0069f172d552997a044790e1a7
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GABRE KLF14 NAV3

8.74e-041615234f25eeabb841b0b9204cdd4e71d5e131e7868184
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_5|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HDAC9 OSM PER1

8.90e-041625230fa93efc9c005d1e649b3f7069ae8641d6e41ed8
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HDAC9 SFI1 EIF2AK3

9.06e-041635238dc0128eeede933537e3bcc5d6ec0322711552f3
ToppCell390C-Lymphocytic-CD4_T-cell-Treg_cell_4|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TBC1D4 SPATS2L POLN

9.06e-04163523bca9abd02ffb2a90c8386a59f5e25126ae7b6acd
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_11|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

HDAC9 SPATS2L REPIN1

9.06e-04163523a09449a502627aa369db600dba5bda93de7ce5c0
ToppCellfacs-Liver-Non-hepatocytes-24m-Myeloid-neutrophil|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OSM PER1 FOXD4

9.06e-04163523abec4389cd88252449f110fe95416d67424b403a
ToppCellCOVID-mono3|COVID / Condition, Cell_class and T cell subcluster

OSM CEP295NL FOXD4

9.06e-041635236ab4cbcd411b40920b81162c0f4b03ea67408f52
ToppCellCOVID-mono3-|COVID / Condition, Cell_class and T cell subcluster

OSM CEP295NL FOXD4

9.06e-0416352326661c7a3a0a449ed32d4b3b28fc2fc0b237025d
ToppCelldroplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HDAC9 SFI1 EIF2AK3

9.06e-04163523fd243ca223079033be480a24817a399f281fa4d4
ToppCellInt-URO-Myeloid-cDC1|Int-URO / Disease, Lineage and Cell Type

HDAC9 SPATS2L REPIN1

9.22e-04164523f4628a7ff0dc765a5337ab499b3d61fc25573a16
ToppCellPND14-Immune-Immune_Myeloid-Granulocytic-Basophil|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

OSM TBC1D4 BSN

9.22e-04164523dc22b1fef49c1557a0b63c536eaba574dfcab715
ToppCellMild-MAIT|World / Disease group and Cell class

HDAC9 MMP24 TAOK1

9.22e-0416452321dc02997dfae73cf70ce291661928526605dba1
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_11|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HDAC9 SPATS2L REPIN1

9.22e-04164523ed888b55d9c685096fd785878fcb264f4fee88d6
ToppCellPND14-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

OSM TBC1D4 BSN

9.22e-04164523f4de9f18134a06f3d7fcf5b50b8e21c1506e2083
ToppCellfacs-Marrow-T_cells-18m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBC1D4 SPATS2L POLN

9.55e-04166523c22b0f3bf990d94b615a3aacee5de548da2db628
ToppCellfacs-Marrow-T_cells-18m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBC1D4 SPATS2L POLN

9.55e-041665230975fc165bcc7e85f053d9d0244fffe407c23571
ToppCellICU-NoSEP-Lymphocyte-T_NK-MAIT|ICU-NoSEP / Disease, Lineage and Cell Type

OSM ZNF775 EBF4

9.55e-04166523d3fa2e42497201f1ca57f4f977fbaa0def950033
ToppCellDividing_Macrophages-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

CDKN2A TCF19 CKAP2

9.55e-04166523ea95b94ccc2ac67df741b30c27f4ae698925875f
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-T_cells-Th1|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TBC1D4 MAP3K8 FURIN

9.71e-041675239c55ec8f70b86d4d3d5c2a6ecd9bff2dafe68c11
ToppCelldroplet-Lung-18m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l26|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

OSM TBC1D4 POLN

9.88e-041685230e99ecd94ab8e5372e30433d7d0aa76b4d54257a
ToppCellBAL-Severe-cDC_5|Severe / Compartment, Disease Groups and Clusters

MAP3K8 PER1 TAOK1

9.88e-04168523857a80c217a5513553460798a625612031bc7bb7
ToppCelldroplet-Lung-18m-Hematologic-myeloid-Basophil/Mast_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

OSM TBC1D4 POLN

9.88e-0416852334722e14f28313f2e4644b3c1861ef12958cee9f
ToppCelldroplet-Lung-nan-18m-Myeloid-Basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OSM TBC1D4 POLN

1.01e-03169523f2e20049a17eee533d49bd5f24a51962d123d132
ToppCelldroplet-Lung-nan-18m-Myeloid-basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OSM TBC1D4 POLN

1.01e-031695234c6892551e9dec94fc62b3beab1e6d424639a1e9
ToppCelldroplet-Lung-nan-3m-Myeloid-basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OSM TBC1D4 POLN

1.01e-03169523da607c1d068038d5a3d1117f6aa6e4c6f3552e97
ToppCelldroplet-Lung-nan-3m-Myeloid-Basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OSM TBC1D4 POLN

1.01e-03169523a14b46231e079a0fd9f3ca13d5d48113be76fd0f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CDKN2A TCF19 CKAP2

1.02e-0317052321bfe070e63722672176052b386167ea4c3dc4e5
ToppCell(7)_MNP-(7)_DC_activated|(7)_MNP / Spleen cell shreds - cell class (v1) and cell subclass (v1)

TBC1D4 RELB FOXD4

1.02e-031705234ab495b38a071fa8207331df2ce0d78a2dcd034e
ToppCellfacs-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CDKN2A TBC1D4 RELB

1.02e-03170523df1a34a69ae404c56f00751a01f52359535f5469
ToppCell356C-Myeloid-Dendritic-cDC_activated|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

TBC1D4 RELB FOXD4

1.02e-03170523513d9036aa41d4d902da8baa66a66206abb6f3b0
ToppCellMild-Treg|World / Disease group and Cell class

HDAC9 TBC1D4 SPATS2L

1.02e-03170523f3f177534badca34e1ae8671b7f583ee6688e14b
ToppCellILEUM-non-inflamed-(3)_MNP-(3)_mature_DC|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

TBC1D4 RELB EBF4

1.04e-03171523341f9f79c1ed654ab347e25dc4936f89ffdf9617
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Activated_DCs|Myeloid_cells / Location, Cell class and cell subclass

TBC1D4 RELB REPIN1

1.04e-03171523ce290930385cac35dbd21a5e91cf0f93cf3e99f8
ToppCellfacs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l15|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CDKN2A TCF19 NAV3

1.06e-03172523de4961f4037c439d3e0ec706a257b0ec17f4d5be
ToppCellfacs-GAT-Fat-18m-Lymphocytic-T_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SIGIRR PCLO FURIN

1.06e-0317252317a486c5d0430abb133eab9f087e2ef8b60f7d25
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-Regulatory_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBC1D4 SIGIRR KLF14

1.06e-031725233acf35b774ebc0f9e96299d0bd3e9d03bbf6b90c
ToppCellPND01-Immune-Immune_Myeloid-Granulocytic-Basophil|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

OSM TBC1D4 FURIN

1.06e-031725236503e85182eb6e8a40a890e393e9ac5c5350e322
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-T4_reg-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

TBC1D4 SPATS2L FAM186B

1.06e-031725239497948bbe53fb88c6ff6b347f743d456da587e5
ToppCelldroplet-Lung-nan-21m-Myeloid-basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OSM TBC1D4 POLN

1.06e-03172523b3c53fd7e50f36de6a8585ae21d04e17932f262c
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-regulatory_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TBC1D4 SIGIRR KLF14

1.06e-031725234d04df9776394ea156ed5822f92ae74fdefbaa3d
Diseaseparental longevity

ATXN2 PCLO FURIN SFI1 BSN FAM186B IQCE

7.92e-06494447EFO_0007796
Diseaseautism spectrum disorder (implicated_via_orthology)

NLGN4X TAOK1 BRINP1 GPRASP2

7.83e-05152444DOID:0060041 (implicated_via_orthology)
Diseasecoronary artery disease, plasminogen activator inhibitor 1 measurement

HDAC9 ATXN2 FURIN

1.15e-0463443EFO_0001645, EFO_0004792
Diseasetissue plasminogen activator measurement, coronary artery disease

HDAC9 ATXN2 FURIN

1.65e-0471443EFO_0001645, EFO_0004791
Diseasemean reticulocyte volume

C20orf203 HDAC9 TBC1D4 POLR1A ATXN2 MBD1 BAHD1

1.66e-04799447EFO_0010701
Diseasebipolar disorder

HDAC9 SPATS2L POLR1A PCLO FURIN BRINP1

2.05e-04577446MONDO_0004985
DiseaseIschemic stroke, tissue plasminogen activator measurement

HDAC9 ATXN2

2.25e-0415442EFO_0004791, HP_0002140
DiseaseIschemic stroke, plasminogen activator inhibitor 1 measurement

HDAC9 ATXN2

2.57e-0416442EFO_0004792, HP_0002140
Diseasefactor XI measurement, Ischemic stroke

HDAC9 ATXN2

2.91e-0417442EFO_0004694, HP_0002140
Diseasetuberculosis

FAM47A SPATS2L NLGN4X NAV3

3.01e-04216444MONDO_0018076
Diseasefactor VIII measurement, Ischemic stroke

HDAC9 ATXN2

3.66e-0419442EFO_0004630, HP_0002140
Diseasecoronary artery disease, factor VII measurement

HDAC9 ATXN2 FURIN

6.13e-04111443EFO_0001645, EFO_0004619
Diseaselarge artery stroke

HDAC9 ATXN2 FURIN

6.46e-04113443EFO_0005524
DiseaseAntihypertensive use measurement

C20orf203 HDAC9 ATXN2 FURIN

6.51e-04265444EFO_0009927
Diseasefactor XI measurement, coronary artery disease

HDAC9 ATXN2 FURIN

6.80e-04115443EFO_0001645, EFO_0004694
Diseasevon Willebrand factor measurement, coronary artery disease

HDAC9 ATXN2 FURIN

7.33e-04118443EFO_0001645, EFO_0004629
Diseaseattention deficit hyperactivity disorder (implicated_via_orthology)

PER1 BRINP1

8.01e-0428442DOID:1094 (implicated_via_orthology)
DiseaseIschemic stroke, factor VII measurement

HDAC9 ATXN2

8.60e-0429442EFO_0004619, HP_0002140
Diseaselongevity, healthspan, parental longevity

ATXN2 FURIN

8.60e-0429442EFO_0004300, EFO_0007796, EFO_0009762
Diseaseangina pectoris

HDAC9 FURIN BRINP1

8.66e-04125443EFO_0003913
Diseasetriglycerides:total lipids ratio, intermediate density lipoprotein measurement

ATXN2 KLF14 RELB

9.06e-04127443EFO_0008595, EFO_0020947
Diseasediastolic blood pressure, unipolar depression

ATXN2 FURIN

9.21e-0430442EFO_0003761, EFO_0006336
DiseaseIschemic stroke, von Willebrand factor measurement

HDAC9 ATXN2

9.21e-0430442EFO_0004629, HP_0002140
Diseaseself rated health

NAV3 BSN

9.83e-0431442EFO_0004778
DiseaseGlobal developmental delay

CACNA1B ZNF142 TAOK1

1.04e-03133443C0557874
Diseasestroke

HDAC9 ATXN2 FURIN

1.30e-03144443EFO_0000712
Diseaselactate measurement

SPATS2L ATXN2

1.55e-0339442EFO_0007745
Diseasemajor depressive disorder

PCLO FURIN BSN

1.61e-03155443MONDO_0002009
Diseasespleen volume

CDKN2A ATXN2

1.89e-0343442EFO_0600047
Diseasemouth morphology measurement

HDAC9 NAV3

2.54e-0350442EFO_0007955
Diseaseattention deficit hyperactivity disorder, bipolar disorder, autism spectrum disorder, schizophrenia, major depressive disorder

PCLO FURIN

2.65e-0351442EFO_0003756, EFO_0003888, MONDO_0002009, MONDO_0004985, MONDO_0005090
Diseaseperipheral arterial disease

HDAC9 ATXN2

2.96e-0354442EFO_0004265
DiseasePeripheral Nervous System Diseases

CDKN2A CACNA1B

2.96e-0354442C4721453
Diseasediastolic blood pressure, alcohol consumption measurement

ATXN2 FURIN

2.96e-0354442EFO_0006336, EFO_0007878

Protein segments in the cluster

PeptideGeneStartEntry
QQHPRHSRPRKTAAS

CEP295NL

186

Q96MC4
RHPVPRQRKCRRQHS

LINC00242

116

Q5T6M2
RRLFHPHPHRQRKES

EIF2AK3

541

Q9NZJ5
LSVRCRHNPNHQLPR

BRINP1

366

O60477
RRGAQLRRPRHSHPT

CDKN2A

81

Q8N726
SRTQSAHQSRRPHLP

FAM186B

581

Q8IYM0
EPRRHRAHRHQDPSK

CACNA1B

931

Q00975
RRRPLPRIHAHDQQL

POLN

741

Q7Z5Q5
QLVRPPIRSHHSNTR

CKAP2

251

Q8WWK9
PPRRRRHRNRAPSSH

ERVK-16

11

P61578
RLRPHVSPRHSFNNL

RELB

211

Q01201
KRPHLRRSASNGHVP

IQCE

121

Q6IPM2
VPDHPHLSRRRRNKR

MMP24

141

Q9Y5R2
RIHSPSERKHERQPR

MMP24

346

Q9Y5R2
KARRSPGRRRHPHSS

PSMG3-AS1

141

Q96PY0
PRMSPKAQRHPRNHR

ATXN2

621

Q99700
KAQRHPRNHRVSAGR

ATXN2

626

Q99700
QQRKARHRSHGPLLP

BSN

1021

Q9UPA5
RRTSKAQRVHPQPSH

C20orf203

66

Q8NBC4
RKRPSSARRHHLGPT

MBD1

406

Q9UIS9
RNPNHRPRAADLLKH

MAP3K8

371

P41279
RSKAKRSRHHQNPRA

PER1

836

O15534
ESKQQRKARHRPHGP

PCLO

1751

Q9Y6V0
DHPPKDLRIRRQHSS

NAV3

1656

Q8IVL0
PPKRRPNHRRFLHNQ

C19orf85

41

A0A1B0GUS0
AHASPKLRHPRINSR

GABRE

371

P78334
RRKRFQRHQPTPGAH

FOXD4

196

Q12950
HNNSKHGRRARRLDP

EBF4

236

Q9BQW3
SLSPHRPRHSRLQRE

FURIN

76

P09958
RHTARSKAARRPSHP

BAHD1

556

Q8TBE0
EHPKTRRRSSLHSQP

FAM47A

481

Q5JRC9
QAPRRRSVTPAAKRH

KLF14

181

Q8TD94
HHRPRQSLRRRPQSS

LCE5A

71

Q5TCM9
GTHKLPRHRPLNRTQ

HDAC9

436

Q9UKV0
DKRRHETHRRPSPQR

NLGN4X

701

Q8N0W4
TAHSARKQPRRPHFL

SFI1

1001

A8K8P3
NRQPTLHRPSIQAHR

POLR1A

551

O95602
APAHSEKPRRRQHAA

SPATS2L

501

Q9NUQ6
SRHRAKHQTNPRSRP

GPRASP2

256

Q96D09
RDPAHPALRLLRQHR

SIGIRR

266

Q6IA17
SPPQVSRHKSHYRNR

TAOK1

421

Q7L7X3
PNRSRRHSPHQALRK

OSM

216

P13725
RRKQLRAHLRRCHPP

REPIN1

156

Q9BWE0
SAPPQRNRRKSVHRV

TCF19

216

Q9Y242
RSLSPRHNTPKGNRR

ZBTB37

161

Q5TC79
QRRPRHRIQSKHRPL

WASH2P

116

Q6VEQ5
QRRPRHRIQSKHRPL

WASHC1

116

A8K0Z3
KPNLTRHRRNHTGER

ZNF775

486

Q96BV0
QRRPRHRIQSKHRPL

WASH3P

116

C4AMC7
QKSQPRRRHASAPSH

TBC1D4

331

O60343
PHLDARPRNSHTNHR

ZNFX1

6

Q9P2E3
RSSPPRAAGHRSHKR

nan

236

Q8N9G6
RLHQKRRHPTAAPAR

ZNF142

1151

P52746
PRHRIQSKHRPLDER

WASH6P

101

Q9NQA3
QVHHSRRARGRRPPQ

ZNF219

666

Q9P2Y4
RLRPNKFRHRHKQTP

MXRA5

1156

Q9NR99