Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	CCZ1B DENND2D BCR TIAM2 TIAM1 CCZ1 KIAA1755 RPGR RHOF RABIF	7.75e-07	231	113	10	GO:0005085
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	CCZ1B DENND2D BCR TIAM2 TIAM1 CCZ1 KIAA1755 RPGR RHOF RABIF	6.12e-04	507	113	10	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	CCZ1B DENND2D BCR TIAM2 TIAM1 CCZ1 KIAA1755 RPGR RHOF RABIF	6.12e-04	507	113	10	GO:0030695
GeneOntologyMolecularFunction	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	INPP5D INPP5J	6.54e-04	7	113	2	GO:0052659
GeneOntologyMolecularFunction	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	INPP5D INPP5J	6.54e-04	7	113	2	GO:0034485
GeneOntologyMolecularFunction	inositol-polyphosphate 5-phosphatase activity	INPP5D INPP5J	8.69e-04	8	113	2	GO:0004445
GeneOntologyMolecularFunction	inositol-1,4,5-trisphosphate 5-phosphatase activity	INPP5D INPP5J	8.69e-04	8	113	2	GO:0052658
GeneOntologyCellularComponent	gamma-tubulin complex	MARK4 MZT2A MZT2B	1.96e-04	21	114	3	GO:0000930
GeneOntologyCellularComponent	extrinsic component of membrane	TENM2 TIAM1 PIK3C2B CLTC KIAA1755 SLA2 UVRAG	2.70e-04	230	114	7	GO:0019898
GeneOntologyCellularComponent	Mon1-Ccz1 complex	CCZ1B CCZ1	2.92e-04	5	114	2	GO:0035658
GeneOntologyCellularComponent	phosphatidylinositol 3-kinase complex	PIK3C2B SLA2 UVRAG	5.20e-04	29	114	3	GO:0005942
Domain	MOZART2	MZT2A MZT2B	3.63e-05	2	113	2	IPR024332
Domain	DUF1712	CCZ1B CCZ1	3.63e-05	2	113	2	PF08217
Domain	MOZART2	MZT2A MZT2B	3.63e-05	2	113	2	PF12926
Domain	DUF1712_fun	CCZ1B CCZ1	3.63e-05	2	113	2	IPR013176
Domain	Quinoprot_gluc/sorb_DH	MED16 EML5 HHIPL2	4.56e-05	12	113	3	IPR011041
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	CBLC PFAS LAMC3 BCR ZBTB42 ADGRA2 LYST C8orf58 TIAM2 RABL6 ZC3H11A KMT2D ZNF276 MDN1 MROH6 TULP4 PIK3C2B RRS1 ZNF408 MARK4 NAV2 PLEC UVRAG RHOF	2.91e-13	1105	117	24	35748872
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	EDC3 CAMKK1 CKAP5 USP43 GIGYF1 BCR LYST MDN1 TIAM1 PIK3C2B SAMD11 SEC24B MARK4 NAV2 ANKRD17 PLEC MAPK4 UVRAG	6.85e-10	861	117	18	36931259
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	EDC3 GIGYF1 BCOR ZC3H11A KMT2D UBR5 SEC24B MKI67 RAVER1	1.35e-08	184	117	9	32908313
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	CHAF1A CAST CKAP5 CBLC MED1 BCOR ZC3H11A KMT2D MDN1 CLTC MKI67 ANKRD17 PLEC KAT6B RAVER1	5.49e-08	774	117	15	15302935
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TNIK ZNF536 CKAP5 TENM2 KIAA0319 ZC3H11A UBR5 RRS1 MARK4 CLTC ST18	1.41e-07	407	117	11	12693553
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	TNIK EDC3 CAST CKAP5 PFAS GPATCH4 MED1 PHAX BCOR ZC3H11A RRS1 SEC24B MKI67 C1orf52 ANKRD17	6.03e-07	934	117	15	33916271
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	ZNF536 PFAS NACAD KIAA0319 MDN1 KAT6B	1.48e-06	104	117	6	9205841
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	TNIK CHAF1A CAST CKAP5 NBEA TULP4 PIK3C2B SEC24B MKI67	1.83e-06	329	117	9	17474147
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FLYWCH1 BCOR BCR ADGRA2 NACAD KIAA1614 TIAM2 NRXN2 NAV2 ANKRD17 KAT6B	1.85e-06	529	117	11	14621295
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	MED16 INPP5D CKAP5 MED1 BCOR MIDEAS ZC3H11A KMT2D UBR5 CCZ1 CLTC MKI67 C1orf52 MZT2B RAVER1	4.63e-06	1103	117	15	34189442
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZNF536 TUT4 CHAF1A PRSS56 GPATCH4 GIGYF1 BCOR BCR KIF7 EML5 UBR5 MARK4 ANKRD17 KAT6B CDH16	5.33e-06	1116	117	15	31753913
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	TNIK LCA5 EDC3 CAST CKAP5 IFT46 BCR KIF7 UBR5 SEC24B PLEC MZT2B RAVER1	6.29e-06	853	117	13	28718761
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	TUT4 EDC3 CAST CKAP5 GPATCH4 MED1 BCR RRS1 MKI67 ANKRD17 PLEC RAVER1	6.32e-06	724	117	12	36232890
Pubmed	Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.	ZNF536 MED1 BCOR MIDEAS KMT2D	9.31e-06	83	117	5	28794006
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	TNIK EDC3 CCDC28A GIGYF1 PHAX LRRC58 BCR RABL6 MROH6 UBR5 PIK3C2B SEC24B UVRAG RHOF	1.08e-05	1038	117	14	26673895
Pubmed	Cytoskeleton-associated protein 5 and clathrin heavy chain binding regulates spindle assembly in mouse oocytes.	CKAP5 CLTC	1.12e-05	2	117	2	28177917
Pubmed	A gene trap integration provides an early in situ marker for hepatic specification of the foregut endoderm.	AFP ANKRD17	1.12e-05	2	117	2	11165478
Pubmed	Nrk, an X-linked protein kinase in the germinal center kinase family, is required for placental development and fetoplacental induction of labor.	NRK MKI67	1.12e-05	2	117	2	21715335
Pubmed	Characterization of STEF, a guanine nucleotide exchange factor for Rac1, required for neurite growth.	TIAM2 TIAM1	1.12e-05	2	117	2	11707441
Pubmed	Roles of STEF/Tiam1, guanine nucleotide exchange factors for Rac1, in regulation of growth cone morphology.	TIAM2 TIAM1	1.12e-05	2	117	2	14550769
Pubmed	Crystallographic characterization of the membrane-targeting domains of the Rac-specific guanine nucleotide-exchange factors Tiam1 and Tiam2.	TIAM2 TIAM1	1.12e-05	2	117	2	18997336
Pubmed	HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.	GPATCH4 MIDEAS ZC3H11A RRS1 MKI67 RAVER1	1.14e-05	148	117	6	32538781
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	CHAF1A CAST MDN1 UBR5 RRS1 CLTC MKI67 ANKRD17 KAT6B RABGGTA	1.47e-05	538	117	10	28524877
Pubmed	KMT2D deficiency disturbs the proliferation and cell cycle activity of dental epithelial cell line (LS8) partially via Wnt signaling.	KMT2D MKI67	3.36e-05	3	117	2	34724040
Pubmed	PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.	CCZ1B CCZ1	3.36e-05	3	117	2	32160108
Pubmed	MZT Proteins Form Multi-Faceted Structural Modules in the γ-Tubulin Ring Complex.	MZT2A MZT2B	3.36e-05	3	117	2	32610146
Pubmed	Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG.	CKAP5 CLTC	3.36e-05	3	117	2	22891263
Pubmed	Clathrin heavy chain mediates TACC3 targeting to mitotic spindles to ensure spindle stability.	CKAP5 CLTC	3.36e-05	3	117	2	20566684
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	LCA5 EDC3 IFT46 GIGYF1 MED1 BCR KIF7 POM121 EML5 TIAM1 SEC24B RPGR UXT PLEC RAVER1	3.83e-05	1321	117	15	27173435
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	TNIK CCZ1B ZNF536 TUT4 EDC3 CHAF1A BCR RRS1 C1orf52 MZT2A MZT2B	3.88e-05	733	117	11	34672954
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	CKAP5 MED1 TIAM1 CLTC ANKRD17 PLEC	6.53e-05	202	117	6	33005030
Pubmed	The in vivo roles of STEF/Tiam1, Rac1 and JNK in cortical neuronal migration.	TIAM2 TIAM1	6.70e-05	4	117	2	12912917
Pubmed	A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging.	CKAP5 CLTC	6.70e-05	4	117	2	21297582
Pubmed	Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex.	BCR TIAM1	6.70e-05	4	117	2	24960694
Pubmed	Neurobeachin: A protein kinase A-anchoring, beige/Chediak-higashi protein homolog implicated in neuronal membrane traffic.	NBEA LYST	6.70e-05	4	117	2	11102458
Pubmed	Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells.	CCZ1B CCZ1	6.70e-05	4	117	2	20305638
Pubmed	The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module.	TIAM2 TIAM1	6.70e-05	4	117	2	19893486
Pubmed	Identification of novel candidate genes in heterotaxy syndrome patients with congenital heart diseases by whole exome sequencing.	KIF7 KMT2D	6.70e-05	4	117	2	32738303
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	CKAP5 PFAS ZC3H11A MDN1 UBR5 RRS1 CLTC MKI67 ANKRD17 PLEC	7.49e-05	653	117	10	22586326
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	CCZ1B EDC3 FLYWCH1 CAST ZCCHC2 BCOR TIAM2 ZC3H11A EML5 CCZ1 CLTC ANKRD17 PLEC	7.56e-05	1084	117	13	11544199
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ZNF536 CKAP5 BCOR BCR KMT2D UBR5 ANKRD17 PLEC	8.87e-05	418	117	8	34709266
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TNIK CKAP5 NBEA BCOR BCR TENM2 KIF7 KIAA0319 MDN1 UBR5 CLTC ANKRD17	1.01e-04	963	117	12	28671696
Pubmed	Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord.	BCR KIAA0319 NAV2	1.02e-04	27	117	3	19026994
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	CAST MED1 PHAX BCOR MIDEAS ZC3H11A KMT2D SEC24B CLTC	1.04e-04	549	117	9	38280479
Pubmed	The p90 ribosomal S6 kinase-UBR5 pathway controls Toll-like receptor signaling via miRNA-induced translational inhibition of tumor necrosis factor receptor-associated factor 3.	RPS6KA1 UBR5	1.11e-04	5	117	2	28559278
Pubmed	Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver.	AFP MKI67	1.11e-04	5	117	2	18669658
Pubmed	Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality.	MKI67 MAPK4	1.11e-04	5	117	2	19805361
Pubmed	Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling.	CBLC SLA2	1.11e-04	5	117	2	12024036
Pubmed	Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG.	CHAF1A UVRAG	1.11e-04	5	117	2	18843052
Pubmed	FcgammaRIIB signals inhibit BLyS signaling and BCR-mediated BLyS receptor up-regulation.	INPP5D BCR	1.11e-04	5	117	2	18791164
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	FLYWCH1 CHAF1A CKAP5 GPATCH4 MED1 BCOR MIDEAS ZC3H11A KMT2D ZNF276 MDN1 MKI67 ZNHIT1 RAVER1	1.18e-04	1294	117	14	30804502
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	TNIK ADGRA2 NRXN2 UBR5 NAV2 KAT6B	1.18e-04	225	117	6	12168954
Pubmed	Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.	CAST CKAP5 LAMC3 RABL6 UBR5 UXT	1.21e-04	226	117	6	31452512
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	MED16 MED1 POM121 UBR5 RRS1 CLTC MKI67 ANKRD17	1.26e-04	440	117	8	34244565
Pubmed	The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing.	POM121 MKI67 ZNHIT1	1.27e-04	29	117	3	17577209
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	CHAF1A CAST CKAP5 ZC3H11A MDN1 CLTC PLEC	1.37e-04	332	117	7	32786267
Pubmed	Tagging genes with cassette-exchange sites.	RPS6KA1 RANBP17 MKI67 NAV2 RPGR PLEC KAT6B	1.45e-04	335	117	7	15741177
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	DNHD1 BCOR KMT2D MDN1 CLTC PLEC	1.46e-04	234	117	6	36243803
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	ZNF536 FLYWCH1 CHAF1A CKAP5 KIF7 ZC3H11A KMT2D MDN1 UBR5 ANKRD17 BARX1	1.55e-04	857	117	11	25609649
Pubmed	Nav2 hypomorphic mutant mice are ataxic and exhibit abnormalities in cerebellar development.	MKI67 NAV2	1.67e-04	6	117	2	21419114
Pubmed	Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl.	INPP5D BCR	1.67e-04	6	117	2	9108392
Pubmed	Systematic identification of factors for provirus silencing in embryonic stem cells.	CHAF1A MDN1 UBR5 ANKRD17 UXT	1.74e-04	153	117	5	26365490
Pubmed	TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains.	MED16 CHAF1A MED1	1.88e-04	33	117	3	33567268
Pubmed	Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.	CES1 NBEA RABGGTA	2.24e-04	35	117	3	15188402
Pubmed	Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs.	RPS6KA1 UBR5	2.33e-04	7	117	2	12594221
Pubmed	The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development.	MED16 MED1	2.33e-04	7	117	2	12093747
Pubmed	Expression pattern of Nav2 in the murine CNS with development.	MKI67 NAV2	2.33e-04	7	117	2	32081718
Pubmed	Dominant role of DNA methylation over H3K9me3 for IAP silencing in endoderm.	AFP MKI67	2.33e-04	7	117	2	36123357
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	TUT4 PFAS BCR TIAM2 POM121 UBR5 RRS1 SEC24B MKI67 INPP5J	2.40e-04	754	117	10	35906200
Pubmed	TRIM65 regulates microRNA activity by ubiquitination of TNRC6.	EDC3 PFAS GPATCH4 PHAX ZC3H11A RRS1 MKI67	2.40e-04	364	117	7	24778252
Pubmed	USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c.	GPATCH4 MKI67 ANKRD17 PLEC	2.49e-04	90	117	4	35654790
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	CKAP5 GIGYF1 RABL6 POM121 SEC24B MKI67	2.74e-04	263	117	6	34702444
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	NBEA RABL6 MDN1 PIK3C2B RRS1 ZNF408 NAV2 ADGRF3	2.88e-04	497	117	8	36774506
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	MED16 MED1 BCOR MIDEAS KMT2D RAVER1	3.03e-04	268	117	6	33640491
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	EDC3 NBEA GPATCH4 RABL6 ZC3H11A UBR5 SEC24B CLTC MKI67 RPGR	3.04e-04	777	117	10	35844135
Pubmed	Paracrine effect of regulatory T cells promotes cardiomyocyte proliferation during pregnancy and after myocardial infarction.	LYST MKI67	3.10e-04	8	117	2	29946151
Pubmed	Tyrosine phosphorylation of SHIP promotes its proteasomal degradation.	INPP5D BCR	3.10e-04	8	117	2	20304029
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	EDC3 CHAF1A GIGYF1 MED1 ZC3H11A MKI67 NAV2 RAVER1	3.12e-04	503	117	8	16964243
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	ZNF536 NBEA MED1 BCOR KIF7 KMT2D MDN1 ANKRD17 RAVER1	3.17e-04	638	117	9	31182584
Pubmed	Human transcription factor protein interaction networks.	ZNF536 EDC3 GPATCH4 GIGYF1 BCOR MIDEAS KIF7 KMT2D SAMD11 SEC24B MKI67 ANKRD17 ZNHIT1 RAVER1	3.25e-04	1429	117	14	35140242
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	GPATCH4 GIGYF1 MIDEAS UBR5 RRS1 MKI67 ANKRD17 PLEC RAVER1	3.83e-04	655	117	9	35819319
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	FLYWCH1 NBEA BCOR KIAA1614	3.86e-04	101	117	4	10997877
Pubmed	Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha.	MED16 MED1	3.98e-04	9	117	2	14636573
Pubmed	Survival and lung pathology of mouse models of Hermansky-Pudlak syndrome and Chediak-Higashi syndrome.	LYST RABGGTA	3.98e-04	9	117	2	10193444
Pubmed	Kif7 promotes hedgehog signaling in growth plate chondrocytes by restricting the inhibitory function of Sufu.	KIF7 MKI67	3.98e-04	9	117	2	21795282
Pubmed	Ectoderm, endoderm, and the evolution of heterodont dentitions.	AFP BARX1	3.98e-04	9	117	2	20533405
Pubmed	Molecular basis for GIGYF-Me31B complex assembly in 4EHP-mediated translational repression.	EDC3 GIGYF1	3.98e-04	9	117	2	31439631
Pubmed	TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4.	MED16 MED1	3.98e-04	9	117	2	12101254
Pubmed	Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex.	MED16 MED1	3.98e-04	9	117	2	8710870
Pubmed	A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression.	MED16 MED1	4.96e-04	10	117	2	12218053
Pubmed	Normal radial migration and lamination are maintained in dyslexia-susceptibility candidate gene homolog Kiaa0319 knockout mice.	KIAA0319 MKI67	4.96e-04	10	117	2	27510895
Pubmed	CDK5RAP2 stimulates microtubule nucleation by the gamma-tubulin ring complex.	MZT2A MZT2B	4.96e-04	10	117	2	21135143
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	EDC3 FLYWCH1 MED16 CHAF1A CKAP5 GPATCH4 DENND2D MED1 BCOR ZC3H11A MDN1 RRS1 SEC24B ANKRD17	5.16e-04	1497	117	14	31527615
Pubmed	Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.	ZNF536 CLTC CARS2 UVRAG	5.34e-04	110	117	4	37219487
Pubmed	Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.	TIAM1 PIK3C2B CLTC ANKRD17	5.52e-04	111	117	4	22558309
Pubmed	Purification and identification of protein-tyrosine kinase-binding proteins using synthetic phosphopeptides as affinity reagents.	INPP5D CLTC	6.05e-04	11	117	2	15215307
Pubmed	Bookmarking by Non-pioneer Transcription Factors during Liver Development Establishes Competence for Future Gene Activation.	AFP MKI67	6.05e-04	11	117	2	32023452
Pubmed	Loss-of-function mutations in FREM2 disrupt eye morphogenesis.	CBLC FREM2	6.05e-04	11	117	2	30802441
Pubmed	Znhit1 Regulates p21Cip1 to Control Mouse Lens Differentiation.	MKI67 ZNHIT1	6.05e-04	11	117	2	35472217
Pubmed	Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain.	LAMC3 MKI67	6.05e-04	11	117	2	21084308
Interaction	TOP3B interactions	CBLC PFAS LAMC3 BCR ZBTB42 ADGRA2 LYST C8orf58 TIAM2 RABL6 ZC3H11A KMT2D ZNF276 MDN1 MROH6 TULP4 PIK3C2B RRS1 ZNF408 SEC24B MARK4 NAV2 ANKRD17 PLEC UVRAG RHOF	1.71e-07	1470	115	26	int:TOP3B
Interaction	YWHAH interactions	LCA5 EDC3 CAMKK1 RPS6KA1 CKAP5 USP43 GIGYF1 MED1 BCR LYST KIF7 TIAM1 PIK3C2B SAMD11 SEC24B MARK4 NAV2 ANKRD17 PLEC UVRAG	3.93e-06	1102	115	20	int:YWHAH
Interaction	YWHAG interactions	LCA5 EDC3 CAMKK1 RPS6KA1 CHAF1A CKAP5 USP43 GIGYF1 BCR LYST KIF7 MDN1 TIAM1 PIK3C2B SAMD11 SEC24B MARK4 CLTC NAV2 ANKRD17 UVRAG	7.03e-06	1248	115	21	int:YWHAG
Interaction	YWHAQ interactions	LCA5 EDC3 CAMKK1 RPS6KA1 CHAF1A USP43 GIGYF1 MED1 BCR LYST PANK1 TIAM1 PIK3C2B SAMD11 CLTC NAV2 ANKRD17 PLEC UVRAG	1.79e-05	1118	115	19	int:YWHAQ
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEA LYST	5.08e-04	9	69	2	1230
ToppCell	droplet-Kidney-nan-18m-Epithelial-collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RTN4R USP43 NBEA MIDEAS NACAD KIAA1755	7.18e-06	176	117	6	533d544852038c0612aacf87f4b1c88ff7aace82
ToppCell	facs-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	THSD1 MYZAP BCR LRG1 NRXN2 HHIPL2	8.70e-06	182	117	6	d22ab50b135482915687c70e6dad29bfe2bb2c68
ToppCell	wk_20-22-Mesenchymal-Chondrocyte-intermediate_chondrocyte\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	ENTPD7 IL11RA CHAF1A SAMD11 NRK MARK4	8.97e-06	183	117	6	1464b5c4425e8776c4aeb4d2b560481d4bf13931
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	ENTPD7 CKAP5 MED1 BCOR LRRC58 CLTC	1.21e-05	193	117	6	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-NPC-like-NPC-like_Prolif-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CKAP5 TENM2 NRXN2 MKI67 LRRN2 RAVER1	1.25e-05	194	117	6	7a66bd7d4fc9c6db861cedd2487f241e406869d1
Disease	cataract 48 (implicated_via_orthology)	TIAM2 TIAM1	1.40e-05	2	111	2	DOID:0070354 (implicated_via_orthology)
Disease	Hermansky-Pudlak syndrome (implicated_via_orthology)	CCZ1B CCZ1 RABGGTA	1.83e-05	14	111	3	DOID:3753 (implicated_via_orthology)
Disease	level of Sterol ester (27:1/18:2) in blood serum	CBLC MARK4 ANKRD17	1.26e-04	26	111	3	OBA_2045194
Disease	stomach cancer (is_marker_for)	CES1 NBEA KMT2D UBR5 MKI67	2.05e-04	142	111	5	DOID:10534 (is_marker_for)
Disease	brain disease (implicated_via_orthology)	TIAM2 TIAM1	2.08e-04	6	111	2	DOID:936 (implicated_via_orthology)
Disease	Hypermetropia	EDC3 PRSS56 TULP4 MARK4	6.30e-04	103	111	4	HP_0000540
Disease	Microphthalmos	PRSS56 KMT2D	7.54e-04	11	111	2	C0026010
Disease	gastric adenocarcinoma (is_implicated_in)	KMT2D UBR5	7.54e-04	11	111	2	DOID:3717 (is_implicated_in)
Disease	antibody measurement	ZNF536 KIAA1755 LRRN2	8.42e-04	49	111	3	EFO_0004556
Disease	frontotemporal dementia, age at onset	TNIK ST18	1.06e-03	13	111	2	EFO_0004847, MONDO_0017276
Disease	Disorder of eye	LCA5 BCOR KIF7 FREM2 RPGR	1.26e-03	212	111	5	C0015397
Disease	C-reactive protein measurement	ZNF536 RPS6KA1 CAST CBLC ZCCHC2 CYP2W1 RANBP17 ZNF276 MROH6 MARK4 LINC00208 UVRAG	1.96e-03	1206	111	12	EFO_0004458
Disease	family history of Alzheimer’s disease	INPP5D CBLC MARK4	2.46e-03	71	111	3	EFO_0009268
Disease	respiratory symptom measurement, COVID-19	FREM2 ST18 RAVER1	2.77e-03	74	111	3	EFO_0007939, MONDO_0100096
Disease	cortical thickness	TNIK ZNF536 CHAF1A LAMC3 ADGRA2 TENM2 KIAA1614 NAV2 KIAA1755 PLEC ST18	3.19e-03	1113	111	11	EFO_0004840
Disease	white matter microstructure measurement	TNIK TENM2 KIAA1614 ZNF276 NAV2 PLEC	3.63e-03	390	111	6	EFO_0005674

Protein segments in the cluster

Peptide	Gene	Start	Entry
QEGRKQGRLLPAPSA	LINC00208	6	Q96KT6
LDLQGDPRESQPLLG	CES1	306	P23141
LSEGPPAEKRQALLG	ADGRF3	956	Q8IZF5
GENQLETLPPDLLRG	LRG1	196	P02750
LLKGNSPPAALGPQD	CBLC	456	Q9ULV8
AGLRLRGPLAQNPKA	ADGRA2	946	Q96PE1
LKDNLIDANGGSRPP	BCR	256	P11274
GADPSLRNKANELPA	ANKRD29	266	Q8N6D5
KEALAGPGQELADRP	CYP2W1	86	Q8TAV3
PPAQVGRLLASQKLG	C8orf58	101	Q8NAV2
LARGPSLGEALKQLP	DNHD1	1471	Q96M86
GDDAPQNAKKARLLP	C1orf52	136	Q8N6N3
GRVLLDKGADVNAPP	ANKRD17	1301	O75179
DFRPKLVNGKGPLDN	CHAF1A	86	Q13111
LGLDRPASDKQSPLN	BCOR	166	Q6W2J9
KRILENPQGLSDPGN	RANBP17	311	Q9H2T7
TALNRGKGLLPEPNI	RAVER1	316	Q8IY67
SDQAPGRDKNIPAGL	RABL6	11	Q3YEC7
QAGSPEKPLSDLGRL	KAT6B	886	Q8WYB5
AGGQKLLQKSRPCDP	HS3ST2	61	Q9Y278
RDGEPKLLQGPDSGL	IL11RA	61	Q14626
LDSTLKGPGNLNRPI	MDN1	3051	Q9NU22
LQALKPPRGGDQNLL	GIGYF1	616	O75420
NRLLGQKTGLSPDNP	ENTPD7	336	Q9NQZ7
LPLSEANEGPSLGNR	KIAA1755	321	Q5JYT7
LPDNKLGDLNGACIP	MAPK4	556	P31152
QREKLPSLALPEGLG	FLYWCH1	186	Q4VC44
AAQGGPAKQLLPLER	CAMKK1	181	Q8N5S9
LDLNKNPLQRVGPGD	LRRN2	266	O75325
DNDALAQRPGRLSPK	FREM2	111	Q5SZK8
QAADQGPLRSKPDLA	KIAA1614	481	Q5VZ46
KPALSDGSNPDGDLL	RABIF	51	P47224
LQLRGKLEAAGPGEP	BARX1	121	Q9HBU1
PRATLGEQEKAGLPL	CCDC28A	6	Q8IWP9
SLKELQSNLGVPPGR	MGAT5B	336	Q3V5L5
FLARLKGQDPGAPQL	GPATCH4	181	Q5T3I0
NLKLGERPPALLGSQ	NRXN2	181	Q9P2S2
LQAEPGLPGAAARKV	KIF7	426	Q2M1P5
RILNEDGSPNLDFKP	NENF	146	Q9UMX5
PLNFLPGNKGSRDQE	LCA5	636	Q86VQ0
SLFQDLGRLQSDPKP	MROH6	641	A6NGR9
ALTLLGGPNRLNPKN	EDC3	316	Q96F86
LDLLGNLPGSKRQPQ	MKI67	2411	P46013
LLAKNNRLGGPSALP	LRRC58	96	Q96CX6
QLDGLARAPGQPKID	MED16	766	Q9Y2X0
IRGLQLLQDGNDPDP	PIK3C2B	1526	O00750
NGDDGLIPQRKSRKP	POTEB3	441	A0JP26
LNDRPNIKCPKGGLA	NPC1L1	1016	Q9UHC9
NGNLLEPRTLLEGPD	POM121	116	Q96HA1
NSLKPLPGEAARALG	KCTD18	401	Q6PI47
ARENIPKSLAGSLGP	EEF1DP3	51	Q658K8
PNIGELPTALKGRLN	CKAP5	896	Q14008
RPDGKPDNLGLLVLD	IFT46	121	Q9NQC8
APDLRATDNGLGKPD	KCNA6	486	P17658
RFLTGPLNLNDPDAK	CCZ1	281	P86791
PPRDLGNLDKGQAAS	CENPJ	1111	Q9HC77
GNLDKGQAASPREPL	CENPJ	1116	Q9HC77
RFLTGPLNLNDPDAK	CCZ1B	281	P86790
LDKLSDSLGQRQPDP	CAST	571	P20810
SRPGAKLNIEGELPA	LYST	3421	Q99698
ERPSLLPNGKENSSG	MARK4	521	Q96L34
ESQLLPDGERLAPNG	MIDEAS	406	Q6PJG2
LAPGSKGLLLEDNPS	EML5	946	Q05BV3
PDGSRLEQPFLDLKN	HHIPL2	246	Q6UWX4
PSLGAGLLQSREDPN	SEC24B	816	O95487
PPADANLSKNGGLEV	SLC22A6	51	Q4U2R8
QLEPRLGALALSPKG	CDH16	181	O75309
RLLQLRAGPPQDNSG	DENND2D	16	Q9H6A0
LNKDAPLPDGRSLQG	MED1	376	Q15648
EKPEGLSPNLNRFLG	AFP	321	P02771
NGCPGLEPLRQKLAA	PRSS56	471	P0CW18
QDRPKSQDSLGLLAP	nan	246	A6NNC1
DRPLQLPKVLGGDSA	PHAX	26	Q9H814
APALRLLNRKPQGGS	PANK1	96	Q8TE04
DLLRAPNSNNSKPLG	NRK	646	Q7Z2Y5
EPENGKLGLPNQLLG	RPGR	216	Q92834
VLEPGRPASAGNALK	RTN4R	346	Q9BZR6
APKRANDSLGGLSPA	SYNPO2L	491	Q9H987
GLGTPDLRQTLPNLK	UVRAG	441	Q9P2Y5
ALAQTAAPGPGRKEL	RHOF	6	Q9HBH0
NGQLRASLKEPEGPR	CARS2	431	Q9HA77
REKAEELLLLPGNPG	SLA2	101	Q9H6Q3
DSGPQGRLPEDVLLK	RABGGTA	196	Q92696
GNLSPIKDPDRLLQD	NBEA	1526	Q8NFP9
LQEPAGEGLPLRKSG	NAV2	66	Q8IVL1
LGKNAGDTLPQEDLP	INPP5D	996	Q92835
KQENGTLALLPGAPD	SAMD11	661	Q96NU1
PSCNGLAEGNKLLAP	TENM2	1226	Q9NT68
RKDPQNALAEPLDGN	ST18	256	O60284
LLDALKNNRPSEGPL	CLTC	566	Q00610
DQAGRPFRPNGLLDK	CYP2D7	166	A0A087X1C5
KANGLSDPGPLADFR	ZCCHC2	151	Q9C0B9
KNAALGPSEPRLALA	INPP5J	46	Q15735
RQTQLGELPNGPLLK	TULP4	306	Q9NRJ4
PALARKNSPGNGSAL	TNIK	681	Q9UKE5
LAPGNSDGPNTARKL	USP43	901	Q70EL4
GLRELQGLQNFPEKP	UXT	141	Q9UBK9
ASLQGGELPNPKRLL	TIAM1	626	Q13009
LQGGELPNPKSLLAA	TIAM2	701	Q8IVF5
LGNLLASDRNPPTGL	RRS1	36	Q15050
PGSNDLLLEVGPRLN	PFAS	81	O15067
LGQPLRKPDLGDHQA	THSD1	731	Q9NS62
AGGDSDPPLKRSLAQ	ZC3H11A	291	O75152
SKDSQPLGPLLQDGD	ZNF408	246	Q9H9D4
LCRAPGQLGEKQLPS	ZNF276	331	Q8N554
KTLPNGRDALDGPAA	PLEC	2761	Q15149
LSPDDPAGLLDLRQG	TNFSF9	76	P41273
ARKPEGSKNLPADGQ	nan	146	Q3C1V9
QGLLQAQDPLAGLPK	ZNF536	1236	O15090
GRLQEKDRSLDPGNP	ZBTB42	116	B2RXF5
QDDPHAGLPQLGKRL	ZNHIT1	41	O43257
AGLPQLGKRLPQFDD	ZNHIT1	46	O43257
NAANLPGPKDLGLVL	TUT4	76	Q5TAX3
PDRLELGKPDNNDGS	UBR5	76	O95071
TELGRPNPLALEAGK	KMT2D	2971	O14686
DLLQPSGKQEPRGSA	KIAA0319	166	Q5VV43
PGALPQKSRAEDLGL	LAMC3	1256	Q9Y6N6
LFKRNPANRLGSGPD	RPS6KA1	296	Q15418
SPQNLKEEGGLDLPS	NACAD	561	O15069
GSAAPPGLEAARQKL	MZT2A	11	Q6P582
GSAAPPGLEAARQKL	MZT2B	11	Q6NZ67
LDLSNGEPTRKLPQG	MYZAP	56	P0CAP1