Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	-	TNPO2 HECTD1 NCAPG2 XPOT EFR3A	4.87e-04	222	55	5	1.25.10.10
Domain	IBN_N	TNPO2 XPOT	8.72e-04	15	55	2	PF03810
Domain	IBN_N	TNPO2 XPOT	9.95e-04	16	55	2	SM00913
Domain	Importin-beta_N	TNPO2 XPOT	1.13e-03	17	55	2	IPR001494
Domain	ARM-like	TNPO2 HECTD1 NCAPG2 XPOT EFR3A	1.17e-03	270	55	5	IPR011989
Domain	RUN	RUFY2 DENND5B	1.26e-03	18	55	2	SM00593
Domain	RUN	RUFY2 DENND5B	1.41e-03	19	55	2	PS50826
Domain	RUN	RUFY2 DENND5B	1.41e-03	19	55	2	PF02759
Domain	Run_dom	RUFY2 DENND5B	1.41e-03	19	55	2	IPR004012
Domain	ARM-type_fold	TNPO2 HECTD1 NCAPG2 XPOT EFR3A	3.17e-03	339	55	5	IPR016024
Domain	Abhydrolase_1	ABHD12B ABHD6	3.75e-03	31	55	2	PF00561
Domain	AB_hydrolase_1	ABHD12B ABHD6	4.24e-03	33	55	2	IPR000073
Domain	zf-C4	THRB PPARA	8.11e-03	46	55	2	PF00105
Domain	Znf_hrmn_rcpt	THRB PPARA	8.11e-03	46	55	2	IPR001628
Domain	Nuclear_hrmn_rcpt	THRB PPARA	8.11e-03	46	55	2	IPR001723
Domain	NUCLEAR_REC_DBD_2	THRB PPARA	8.11e-03	46	55	2	PS51030
Domain	NUCLEAR_REC_DBD_1	THRB PPARA	8.11e-03	46	55	2	PS00031
Domain	ZnF_C4	THRB PPARA	8.11e-03	46	55	2	SM00399
Domain	-	THRB PPARA	8.46e-03	47	55	2	1.10.565.10
Domain	HOLI	THRB PPARA	8.81e-03	48	55	2	SM00430
Domain	Nucl_hrmn_rcpt_lig-bd	THRB PPARA	8.81e-03	48	55	2	IPR000536
Domain	Hormone_recep	THRB PPARA	8.81e-03	48	55	2	PF00104
Domain	HEAT	TNPO2 NCAPG2	8.81e-03	48	55	2	PF02985
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	NIFK DSP NUP210 RCL1 URB2 HECTD1 CNOT1 TASOR2 XPOT	9.47e-07	653	56	9	22586326
Pubmed	Cloning of novel members of the steroid hormone receptor superfamily.	THRB PPARA	2.55e-06	2	56	2	1958530
Pubmed	Tagging genes with cassette-exchange sites.	MAP4K3 TNPO2 RABGAP1L SOCS4 GPATCH8 XPOT	1.65e-05	335	56	6	15741177
Pubmed	Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor.	THRB PPARA	2.54e-05	5	56	2	9325263
Pubmed	Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor.	THRB PPARA	3.80e-05	6	56	2	11733490
Pubmed	Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors.	THRB PPARA	3.80e-05	6	56	2	9795230
Pubmed	Nuclear receptor binding factor-2 (NRBF-2), a possible gene activator protein interacting with nuclear hormone receptors.	THRB PPARA	3.80e-05	6	56	2	10786636
Pubmed	Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation.	THRB PPARA	5.32e-05	7	56	2	11903058
Pubmed	Chromosome localization of the mouse zonadhesin gene and the human zonadhesin gene (ZAN).	LIMK1 ZAN	7.09e-05	8	56	2	9126492
Pubmed	Cloning and characterization of RAP250, a novel nuclear receptor coactivator.	THRB PPARA	7.09e-05	8	56	2	10681503
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	NIFK ZNF592 NUP210 MAD2L2 CNOT1 TASOR2	1.07e-04	469	56	6	27634302
Pubmed	The developmental regulation of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression in the liver is partially dissociated from the control of gluconeogenesis and lipid catabolism.	PPARA ACOX3	1.14e-04	10	56	2	15178647
Pubmed	Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription.	THRB CNOT1	1.14e-04	10	56	2	16778766
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ENOSF1 THRB NUP210 PRKAR1B PPARA HECTD1 CNOT1 SLC4A5 CKLF TASOR2	1.18e-04	1489	56	10	28611215
Pubmed	TBL2, a novel transducin family member in the WBS deletion: characterization of the complete sequence, genomic structure, transcriptional variants and the mouse ortholog.	LIMK1 ZAN	1.39e-04	11	56	2	10575226
Pubmed	Seventy-five genetic loci influencing the human red blood cell.	THRB ABO RCL1	1.40e-04	62	56	3	23222517
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	ZBTB38 ZNF592 DSP TAX1BP1 PPARA MAD2L2	1.47e-04	497	56	6	23414517
Pubmed	Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma.	ABO AGBL2	1.66e-04	12	56	2	25173106
Pubmed	Condensin I and II Complexes License Full Estrogen Receptor α-Dependent Enhancer Activation.	HECTD1 NCAPG2	2.29e-04	14	56	2	26166704
Pubmed	Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha.	THRB PPARA	2.29e-04	14	56	2	12039952
Pubmed	Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis.	LRRC34 DSP	2.64e-04	15	56	2	23583980
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	RUFY2 RABGAP1L TAX1BP1 FASTKD1 TOR1A NCAPG2 XPOT SEMA4C	2.83e-04	1061	56	8	33845483
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	DSP NUP210 HECTD1 CNOT1	3.20e-04	202	56	4	33005030
Pubmed	Phosphoproteome analysis of the human mitotic spindle.	DSP NUP210 GPATCH8 NCAPG2	3.71e-04	210	56	4	16565220
Pubmed	Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein alpha.	THRB PPARA	5.24e-04	21	56	2	11940593
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	DSP NUP210 TOR1A PFKFB3 CNOT1 XPOT	6.47e-04	657	56	6	36180527
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	NIFK DSP NUP210 ABHD6 URB2 GPATCH8 CNOT1 XPOT	6.51e-04	1203	56	8	29180619
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	NIFK ZNF592 NUP210 GPATCH8 HECTD1	7.12e-04	440	56	5	34244565
Pubmed	Capillary endothelial fatty acid binding proteins 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle.	PPARA PFKFB3	7.46e-04	25	56	2	23968980
Pubmed	Identification of 15 loci influencing height in a Korean population.	ZBTB38 KBTBD8	8.71e-04	27	56	2	19893584
Pubmed	Recent acquisition of imprinting at the rodent Sfmbt2 locus correlates with insertion of a large block of miRNAs.	ST8SIA6 PFKFB3	8.71e-04	27	56	2	21510876
Pubmed	Genome-wide association study of hematological and biochemical traits in a Japanese population.	THRB ABO RCL1	8.81e-04	116	56	3	20139978
Pubmed	Genomic architecture of Shh-dependent cochlear morphogenesis.	THRB DSP	9.37e-04	28	56	2	31488567
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	RUFY2 LIMK1 ZBTB38 ZNF592 DSP TNPO2 HECTD1 XPOT	9.98e-04	1285	56	8	35914814
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	DSP TAX1BP1 NUP210 TOR1A URB2 HECTD1 CNOT1 XPOT	1.06e-03	1297	56	8	33545068
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	TNPO2 NUP210 FASTKD1 TOR1A URB2 HECTD1	1.32e-03	754	56	6	33060197
Pubmed	Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy.	THRB URB2 MAD2L2	1.42e-03	137	56	3	30862715
Pubmed	Fine-scale comparative mapping of the human 7q11.23 region and the orthologous region on mouse chromosome 5G: the low-copy repeats that flank the Williams-Beuren syndrome deletion arose at breakpoint sites of an evolutionary inversion(s).	LIMK1 ZAN	1.46e-03	35	56	2	11013070
Pubmed	Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.	ZAN RCL1	1.46e-03	35	56	2	19862010
Cytoband	10p15.1	PFKFB3 TASOR2	5.41e-04	28	56	2	10p15.1
Cytoband	14q22.1	ABHD12B SOCS4	6.22e-04	30	56	2	14q22.1
Cytoband	16q21	CNOT1 CKLF	1.40e-03	45	56	2	16q21
GeneFamily	Abhydrolase domain containing	ABHD12B ABHD6	8.21e-04	22	35	2	4
Coexpression	GSE20366_CD103_POS_VS_CD103_KLRG1_DP_TREG_UP	THRB DSP MAP4K3 RABGAP1L PCDHB15 XPOT	3.89e-06	200	55	6	M4344
Disease	glucose-dependent insulinotropic peptide measurement, glucose tolerance test	ABO ST8SIA6	2.84e-04	14	53	2	EFO_0004307, EFO_0008464
Disease	asthma, endometriosis	ABO RABGAP1L XPOT	3.24e-04	74	53	3	EFO_0001065, MONDO_0004979
Disease	citrate measurement	ABO PFKFB3 CNOT1	3.93e-04	79	53	3	EFO_0010114
Disease	blood aluminium measurement	ZBTB38 EFR3A	5.89e-04	20	53	2	EFO_0007575
Disease	complement factor D measurement	ABO ZNF519 EFR3A	6.33e-04	93	53	3	EFO_0020283
Disease	interleukin-2 receptor subunit alpha measurement	PFKFB3 TASOR2	6.50e-04	21	53	2	EFO_0010587
Disease	hemoglobin measurement, mean corpuscular hemoglobin	THRB RCL1	7.15e-04	22	53	2	EFO_0004509, EFO_0004527
Disease	Huntington disease, disease progression measurement	ST8SIA6 EFR3A	1.33e-03	30	53	2	EFO_0008336, MONDO_0007739
Disease	thyroid carcinoma	ENOSF1 LRRC34	2.25e-03	39	53	2	EFO_0002892
Disease	diet measurement	ZBTB38 ABO ST8SIA6 PFKFB3 GPATCH8 MAP2K5 CNOT1	2.60e-03	1049	53	7	EFO_0008111
Disease	obsolete_red blood cell distribution width	THRB ABO ST8SIA6 RABGAP1L NUP210 RCL1 KBTBD8 FDXACB1	2.63e-03	1347	53	8	EFO_0005192

Protein segments in the cluster

Peptide	Gene	Start	Entry
SILQCHPKVMLKAIP	URB2	1376	Q14146
VKFLPKNLHLVCVDM	ABHD6	91	Q9BV23
KPKCHALRPMILFLI	ABO	11	P16442
MFKSPLKVPALIQCL	ACOX3	96	O15254
MVIFPPGFQHNLLCK	ABHD12B	331	Q7Z5M8
LPEHIFRDKCMLPKS	EFR3A	636	Q14156
LECHFMPPEKVHKEL	NIFK	116	Q9BYG3
SLLCLAPFMKHPLKI	RCL1	101	Q9Y2P8
IMIHDLCLVFPAPAK	NUP210	956	Q8TEM1
QKFMLIKHIDFPIPC	MAP4K3	706	Q8IVH8
IKHIDFPIPCPLRMF	MAP4K3	711	Q8IVH8
AICKPLQYPLVMNHK	OR10AG1	116	Q8NH19
CMEKSQKINPFILHI	LRRC34	61	Q8IZ02
KKYNVPVQMSCHPEL	MAD2L2	46	Q9UI95
VLLMAKKFEIPVCPH	ENOSF1	341	Q7L5Y1
HCKVKPNFPFLLFMR	GPATCH8	401	Q9UKJ3
PFVHFITQCMRKQPK	MAP2K5	391	Q13163
ETHCPKMNLPAKYVI	PGLYRP3	191	Q96LB9
EMPYLKCPLHTVLKL	PFKFB3	406	Q16875
PCIMHFQVLLKKPLE	PCDHB15	101	Q9Y5E8
AKFPLCMVFHIIDLL	RABGAP1L	706	Q5R372
HLPEIFAKCIRFPLM	KBTBD8	231	Q8NFY9
LVDLPISKPFFKLMC	HECTD1	2261	Q9ULT8
VPLLTHLLCLPMKFK	DCST1	276	Q5T197
KKYPCDKNMPLQHLL	DSP	401	P15924
MIPLCNHPASFVKLF	FASTKD1	296	Q53R41
LHAIAKDPKMVVCPL	GALNTL5	241	Q7Z4T8
TPLPFMQACKKFLIQ	DENND5B	196	Q6ZUT9
PLMLCKNAPDKFSFH	AGBL2	586	Q5U5Z8
VHLCISKPERPMKFL	PRKAR1B	36	P31321
KYPCLLQHLMPQEKE	CCDC168	3411	Q8NDH2
VFQKCHILPFTMPAF	FDXACB1	376	Q9BRP7
HPDDIFLFPKLLQKM	PPARA	416	Q07869
CKPLHYKRILTPQVM	OR52I1	131	Q8NGK6
VHKKCPLCELMFPPN	TAX1BP1	726	Q86VP1
PPLQQFFVVMEHCLK	RUFY2	41	Q8WXA3
KIHISELMLDKCPFP	SOCS4	121	Q8WXH5
EIPIKKNIFHMFPVS	ST8SIA6	161	P61647
LPDNILNFVKKHPLM	SEMA4C	386	Q9C0C4
MDNVQPKIKHRPFCF	CKLF	1	Q9UBR5
FKCLPMILDNKLSHP	NCAPG2	441	Q86XI2
QLFSFPIKHCPDMLV	CNOT1	471	A5YKK6
KCLILLVPSFIMPFK	RNFT1	266	Q5M7Z0
TEPCIPMNKYQHKFL	ZNF519	136	Q8TB69
FVPFLPLEYKHLKMC	TOR1A	266	O14656
FIHVKPCIAEFMPIL	TNPO2	696	O14787
ECPLLFVQKPELMQH	ZNF592	896	Q92610
HMKVECPTELFPPLF	THRB	441	P10828
ERCKLFLMPAKHQPD	SLC4A5	991	Q9BY07
PATCKQELPKLMDLH	ZNF75D	341	P51815
DILCFNFPSKMIKLP	VN1R5	26	Q7Z5H4
KFFTVEPQHIPCVLM	XPOT	511	O43592
KVFEMLLHKIPLICQ	TOMM20L	121	Q6UXN7
PHMVQSKKVNLCRPF	TASOR2	356	Q5VWN6
MQLHKPTQEPLVCKY	ZBTB38	361	Q8NAP3
VLVKVCHPAMALPFF	ZAN	1956	Q9Y493
KVMRCLEHPNVLKFI	LIMK1	386	P53667