Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnucleosome binding

HDAC2 MLLT6

1.05e-0398102GO:0031491
GeneOntologyMolecularFunctionhistone binding

HDAC2 MLLT6

7.36e-03265102GO:0042393
MousePhenoscoliosis

LASP1 ENPP1

5.68e-046482MP:0000161
MousePhenoabnormal vertebral body morphology

LASP1 ENPP1

6.04e-046682MP:0000141
MousePhenoabnormal intervertebral disk morphology

LASP1 ENPP1

6.22e-046782MP:0004173
MousePhenoabnormal symphysis morphology

LASP1 ENPP1

6.98e-047182MP:0030877
MousePhenoabnormal exocrine gland morphology

WRNIP1 LASP1 HDAC2 ENPP1

7.90e-0485384MP:0013558
MousePhenoabnormal cartilaginous joint morphology

LASP1 ENPP1

9.99e-048582MP:0030875
MousePhenoabnormal response/metabolism to endogenous compounds

LASP1 HDAC2

1.49e-0310482MP:0003638
MousePhenoabnormal fibrous joint morphology

LASP1 ENPP1

2.50e-0313582MP:0030878
MousePhenoabnormal vertebrae morphology

LASP1 HDAC2 ENPP1

2.86e-0354683MP:0000137
MousePhenoabnormal spinal reflex

WRNIP1 HDAC2

2.99e-0314882MP:0012079
MousePhenoabnormal response to tactile stimuli

WRNIP1 HDAC2

2.99e-0314882MP:0005316
MousePhenoabnormal digestive system morphology

WRNIP1 LASP1 HDAC2 MLLT6

3.16e-03123384MP:0000462
MousePhenoabnormal reflex

WRNIP1 PLA2G7 HDAC2 ENPP1

3.77e-03129484MP:0001961
MousePhenoabnormal internal male genitalia morphology

WRNIP1 ADAM7 LASP1 HDAC2

4.93e-03139284MP:0009205
MousePhenoabnormal male reproductive system morphology

WRNIP1 ADAM7 LASP1 HDAC2

5.24e-03141584MP:0001145
MousePhenoabnormal male genitalia morphology

WRNIP1 ADAM7 LASP1 HDAC2

5.24e-03141584MP:0009198
MousePhenoabnormal sensory capabilities/reflexes/nociception

WRNIP1 PLA2G7 HDAC2 ENPP1

6.26e-03148684MP:0002067
MousePhenodigestive/alimentary phenotype

WRNIP1 LASP1 HDAC2 MLLT6

6.48e-03150084MP:0005381
MousePhenoabnormal total retina thickness

WRNIP1 HDAC2

6.66e-0322382MP:0011963
MousePhenoabnormal induced morbidity/mortality

PLA2G7 LASP1 ENPP1

6.69e-0373783MP:0001657
DomainKRAB

ZNF177 ZNF585A

1.49e-02358102PS50805
DomainKRAB

ZNF177 ZNF585A

1.49e-02358102PF01352
DomainKRAB

ZNF177 ZNF585A

1.58e-02369102SM00349
DomainKRAB

ZNF177 ZNF585A

1.59e-02370102IPR001909
PathwayWP_17Q12_COPY_NUMBER_VARIATION_SYNDROME

LASP1 MLLT6

7.19e-049962M46448
PathwayWP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES

PLA2G7 ENPP1

1.02e-0238162M48063
Pubmed

Mutagenic transgene insertion into a region of high gene density and multiple linkage disruptions on mouse chromosome 11.

LASP1 MLLT6

6.76e-061410212438746
Pubmed

Age-associated alteration of gene expression patterns in mouse oocytes.

WRNIP1 HDAC2

9.42e-055110215317747
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

WRNIP1 LASP1 HDAC2 MLLT6

1.81e-04110310434189442
Pubmed

The Deubiquitinase USP37 Regulates Chromosome Cohesion and Mitotic Progression.

WRNIP1 HDAC2

2.56e-048410226299517
CytobandEnsembl 112 genes in cytogenetic band chr17q12

LASP1 MLLT6

4.63e-04149102chr17q12
CoexpressionMYLLYKANGAS_AMPLIFICATION_HOT_SPOT_12

LASP1 MLLT6

7.19e-0611102M16845
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLCO6A1 ENPP1

4.88e-041501027a9d6a7ff8000e9a061e1b586e4c258cc91a2a09
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLCO6A1 ENPP1

4.88e-04150102e5b843cb2bc847f6cab4cbec0a2a6a72fac50fee
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ZNF177 PLA2G7

5.55e-041601026d941e584360975e1fdbb2fc67af8e31f18759d8
ToppCellsaliva-Severe-critical_progression_d28-40-Myeloid-Macrophage-macrophage,_alveolar-Macro_c6-VCAN|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

ZNF585A ENPP1

5.55e-041601028374ae912337947b2cc8d17d5840f306361fe1ff
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage|368C / Donor, Lineage, Cell class and subclass (all cells)

ZNF177 PLA2G7

6.48e-04173102bba8265a58f8f5659dc7b9da2fe27b15033fce34
ToppCelldroplet-Marrow-nan-18m-Hematologic-proerythroblast|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLA2G7 LASP1

6.48e-0417310203cee3d24bc433e91a867ce951589de64a0538af
ToppCelldroplet-Marrow-nan-18m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLA2G7 LASP1

6.78e-041771025d70fe2b0592362d664b3b4c84eb450ec2335957
ToppCelldroplet-Marrow-nan-18m-Hematologic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLA2G7 LASP1

6.78e-0417710248bcf603ec9593eedd81f3831cf9fde89fad368f
ToppCell10x_5'_v1-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PLA2G7 ENPP1

6.86e-04178102c90e9048fc786ba8559972ae25c25ecab4bc1b7c
ToppCell10x_5'_v1-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PLA2G7 ENPP1

6.86e-041781029e426ce23a4a33b91d139ad85685cf8483bcd01a
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Dendritic-conventional_dendritic_cell|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LASP1 ENPP1

7.41e-041851022aa5e9f6f167d27317a01d22392b59512333fa64
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Dendritic|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

LASP1 ENPP1

7.41e-04185102405bd4ba7ca7f7b625c49f1313ff946509e17c13
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLCO6A1 ENPP1

8.05e-04193102e5016959f24370579a8770787e96869f264cf7b3
ToppCellControl-Myeloid-MoAM4|Myeloid / Condition, Lineage and Cell class

PLA2G7 ENPP1

8.14e-041941027ab808dd1876b0eec2831caa16d04fd859b1dc50
ToppCellControl-Myeloid-MoAM4|Control / Condition, Lineage and Cell class

PLA2G7 ENPP1

8.22e-04195102211a736acbe875bd3c1942c62aaacc9b170ece6d
ToppCellCaecum-ILC|Caecum / Region, Cell class and subclass

MLLT6 ENPP1

8.64e-04200102a9a1f03b4f415da860fb52eaedb07f0743692c98
ToppCellCaecum-(3)_ILC-(30)_ILC|Caecum / shred on region, Cell_type, and subtype

MLLT6 ENPP1

8.64e-04200102ccd323997613b65f0189c0c66d76fbf273e18c03
ToppCellCaecum-ILC-ILC|Caecum / Region, Cell class and subclass

MLLT6 ENPP1

8.64e-042001023ac18c3ef335cb83d6a826f6c7519a5e7804929d
ToppCellCaecum-(3)_ILC|Caecum / shred on region, Cell_type, and subtype

MLLT6 ENPP1

8.64e-042001026857863b3200162c250123688af2cba681afcb35
DrugRodeo

WRNIP1 HDAC2

2.35e-0517102CID000038078
Drug20 alpha-hydroxycholesterol

HDAC2 ENPP1

5.66e-0482102CID000121935
Drug4-nitro-phen-yl

PLA2G7 ENPP1

7.27e-0493102CID000119211
Drugp-hydroxymandelonitrile

LASP1 MLLT6

1.15e-03117102CID000166768
Drugbenomyl

WRNIP1 ENPP1

1.37e-03128102CID000028780
DrugTopo

LASP1 MLLT6

1.95e-03153102CID000065577
DrugPergolide mesylate [66104-23-2]; Up 200; 9.8uM; HL60; HT_HG-U133A

PLA2G7 LASP1

2.29e-031661022403_UP
DrugWarfarin

LASP1 ENPP1

2.29e-03166102ctd:D014859
Drugglycerol-3-phosphocholine

PLA2G7 ENPP1

2.45e-03172102CID000000823
DrugBromocryptine mesylate [22260-51-1]; Up 200; 5.4uM; HL60; HG-U133A

PLA2G7 LASP1

2.48e-031731022007_UP
Drugmolybdenum

LASP1 MLLT6

2.71e-03181102CID000023932
Druglipopolysaccharide, Escherichia coli O111 B4

PLA2G7 ENPP1

2.92e-03188102ctd:C440499
DrugTolazamide [1156-19-0]; Up 200; 12.8uM; PC3; HT_HG-U133A

WRNIP1 ENPP1

3.14e-031951024003_UP
DrugProadifen hydrochloride [62-68-0]; Up 200; 10.2uM; HL60; HT_HG-U133A

WRNIP1 PLA2G7

3.17e-031961022707_UP
DrugBromopride [4093-35-0]; Up 200; 11.6uM; MCF7; HT_HG-U133A

ADAM7 PLA2G7

3.20e-031971023617_UP
DrugMethacycline hydrochloride [3963-95-9]; Up 200; 8.4uM; MCF7; HT_HG-U133A

WRNIP1 ADAM7

3.20e-031971024143_UP
DrugLetrozole [112809-51-5]; Up 200; 14uM; PC3; HT_HG-U133A

WRNIP1 PLA2G7

3.20e-031971024240_UP
DrugNilutamide [63612-50-0]; Up 200; 12.6uM; PC3; HT_HG-U133A

PLA2G7 ENPP1

3.23e-031981026763_UP
Drug0317956-0000 [391210-11-0]; Up 200; 10uM; MCF7; HT_HG-U133A

WRNIP1 PLA2G7

3.27e-031991023966_UP
DrugBendroflumethiazide [73-48-3]; Up 200; 9.4uM; MCF7; HT_HG-U133A

ADAM7 ENPP1

3.27e-031991023934_UP
DrugFurazolidone [67-45-8]; Up 200; 17.8uM; HL60; HT_HG-U133A

ADAM7 ENPP1

3.30e-032001023019_UP
Drugmethenamine silver

LASP1 MLLT6

3.33e-03201102CID000004101
Drugphosphorylcholine

PLA2G7 ENPP1

3.33e-03201102CID000001014
DiseaseEndometrioma

HDAC2 ENPP1

1.29e-03161102C0269102
DiseaseEndometriosis

HDAC2 ENPP1

1.29e-03161102C0014175
Diseasetype 2 diabetes mellitus (is_implicated_in)

PLA2G7 ENPP1

1.46e-03171102DOID:9352 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
VKYCGYCKYHFSKMK

MLLT6

171

P55198
CYKMNTKGNKFGYCK

ADAM7

526

Q9H2U9
MKNYKGYEKKPYCNA

LASP1

41

Q14847
MEQGSCKKYIYLNKY

ENPP1

426

P22413
YFQYPANIIKMKKCY

PLA2G7

321

Q13093
MAYSQGGGKKKVCYY

HDAC2

1

Q92769
GCTYSKAQNQKKMYY

SLCO6A1

531

Q86UG4
YCKGEKCYKYIKYSK

ZNF177

141

Q13360
QKMYPGEKAYECAKF

ZNF585A

121

Q6P3V2
MKDLGYGKGYKYNPM

WRNIP1

626

Q96S55