Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sodium channel activity	GRIK1 SCN4A SCN5A SCN8A	1.18e-04	52	97	4	GO:0005272
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN4A SCN5A SCN8A	2.66e-04	26	97	3	GO:0005248
GeneOntologyMolecularFunction	MAP kinase kinase kinase kinase activity	MAP4K3 MAP4K1	3.46e-04	6	97	2	GO:0008349
GeneOntologyCellularComponent	sodium channel complex	GRIK1 SCN4A SCN5A SCN8A	9.86e-06	29	98	4	GO:0034706
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN4A SCN5A SCN8A	6.48e-05	17	98	3	GO:0001518
Domain	IQ	ADGB SCN4A SCN5A MYO1F SCN8A IQCE	4.22e-06	81	98	6	SM00015
Domain	IQ_motif_EF-hand-BS	ADGB SCN4A SCN5A MYO1F SCN8A IQCE	7.80e-06	90	98	6	IPR000048
Domain	IQ	ADGB SCN4A SCN5A MYO1F SCN8A IQCE	9.43e-06	93	98	6	PS50096
Domain	Na_channel_asu	SCN4A SCN5A SCN8A	1.64e-05	10	98	3	IPR001696
Domain	Na_trans_assoc	SCN4A SCN5A SCN8A	1.64e-05	10	98	3	IPR010526
Domain	Na_trans_assoc	SCN4A SCN5A SCN8A	1.64e-05	10	98	3	PF06512
Domain	Znf_FYVE_PHD	RAG2 PCLO BAZ1B DIDO1 PHF2 RIMS2	1.25e-04	147	98	6	IPR011011
Domain	ZF_PHD_2	RAG2 BAZ1B DIDO1 PHF2 RAI1	1.43e-04	95	98	5	PS50016
Domain	ZF_PHD_1	RAG2 BAZ1B DIDO1 PHF2 RAI1	1.50e-04	96	98	5	PS01359
Domain	MAPKKKK	MAP4K3 MAP4K1	1.62e-04	4	98	2	IPR021160
Domain	Na_trans_cytopl	SCN5A SCN8A	4.03e-04	6	98	2	PF11933
Domain	Na_trans_cytopl	SCN5A SCN8A	4.03e-04	6	98	2	IPR024583
Domain	IQ	SCN4A MYO1F SCN8A IQCE	5.29e-04	71	98	4	PF00612
Domain	G_CP_dom	NOA1 GNL1	5.63e-04	7	98	2	IPR030378
Domain	G_CP	NOA1 GNL1	5.63e-04	7	98	2	PS51721
Domain	zf-C2H2_11	ZNF532 ZNF592	9.58e-04	9	98	2	PF16622
Domain	PHD	BAZ1B DIDO1 PHF2 RAI1	1.24e-03	89	98	4	SM00249
Domain	Znf_PHD	BAZ1B DIDO1 PHF2 RAI1	1.34e-03	91	98	4	IPR001965
Domain	-	DHX16 NOA1 SPEF2 ABCC5 RHOU DHX9 DNAH1 SAMD9L MYO1F EIF5B GNL1	1.82e-03	746	98	11	3.40.50.300
Domain	CNH	MAP4K3 MAP4K1	2.38e-03	14	98	2	SM00036
Domain	CNH	MAP4K3 MAP4K1	2.74e-03	15	98	2	PF00780
Domain	CNH	MAP4K3 MAP4K1	2.74e-03	15	98	2	PS50219
Domain	CNH_dom	MAP4K3 MAP4K1	2.74e-03	15	98	2	IPR001180
Domain	Ion_trans_dom	SCN4A SCN5A SCN8A TRPM1	3.06e-03	114	98	4	IPR005821
Domain	Ion_trans	SCN4A SCN5A SCN8A TRPM1	3.06e-03	114	98	4	PF00520
Domain	Channel_four-helix_dom	SCN4A SCN5A SCN8A	3.34e-03	57	98	3	IPR027359
Domain	-	SCN4A SCN5A SCN8A	3.34e-03	57	98	3	1.20.120.350
Domain	MMR_HSR1	NOA1 GNL1	3.52e-03	17	98	2	PF01926
Domain	DUF1605	DHX16 DHX9	3.52e-03	17	98	2	IPR011709
Domain	OB_NTP_bind	DHX16 DHX9	3.52e-03	17	98	2	PF07717
Domain	HA2	DHX16 DHX9	3.95e-03	18	98	2	SM00847
Domain	HA2	DHX16 DHX9	3.95e-03	18	98	2	PF04408
Domain	Helicase-assoc_dom	DHX16 DHX9	3.95e-03	18	98	2	IPR007502
Domain	GTP_binding_domain	NOA1 GNL1	4.40e-03	19	98	2	IPR006073
Domain	Zinc_finger_PHD-type_CS	BAZ1B DIDO1 PHF2	4.84e-03	65	98	3	IPR019786
Domain	P-loop_NTPase	DHX16 NOA1 SPEF2 ABCC5 RHOU DHX9 DNAH1 SAMD9L MYO1F EIF5B GNL1	4.85e-03	848	98	11	IPR027417
Domain	Znf_C2H2_jaz	DNAJC21 ZNF385B	5.88e-03	22	98	2	IPR022755
Domain	zf-C2H2_jaz	DNAJC21 ZNF385B	5.88e-03	22	98	2	PF12171
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	DHX16 SIN3B TMA16 BCORL1 BAZ1B DIDO1 LYAR HP1BP3 PHF2 ZNF592 UBTF TPX2 ELF2 CDC27 RAI1 DNMT1 NPAT	1.31e-12	608	98	17	36089195
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	NOP56 BCORL1 BAZ1B DIDO1 RPS25 LYAR HP1BP3 DHX9 PHF2 SUGP2 UBTF AHNAK TPX2 EIF5B ELF2 L3MBTL3 LCOR RAI1 DNMT1 NPAT	2.17e-12	954	98	20	36373674
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SIN3B TMA16 NOP56 MAFK BCORL1 BAZ1B DIDO1 RPS25 LYAR HP1BP3 DHX9 PHF2 UBTF AHNAK TPX2 ELF2 CDC27 L3MBTL3 LCOR RAI1 DNMT1	6.78e-11	1294	98	21	30804502
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	DHX16 TMA16 NOP56 BAZ1B DIDO1 RPS25 LYAR HP1BP3 DHX9 SUGP2 UBTF AHNAK EIF5B DNMT1	1.57e-09	601	98	14	33658012
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	SIN3B TMA16 MAFK BCORL1 DIDO1 PHF2 LIG1 SUGP2 UBTF TPX2 EIF5B ELF2 L3MBTL3 LCOR HSPA4 RAI1 DNMT1	1.20e-08	1103	98	17	34189442
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	NOP56 BAZ1B DNAJC21 DIDO1 RPS25 LYAR HP1BP3 DHX9 SUGP2 UBTF PNMA8A TPX2 L3MBTL3 DNMT1	2.97e-08	759	98	14	35915203
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	SIN3B NOP56 BCORL1 DIDO1 SUGP2 UBTF ELF2 L3MBTL3 DNMT1 NPAT	4.45e-08	339	98	10	30415952
Pubmed	Human transcription factor protein interaction networks.	SIN3B NOP56 SH3KBP1 BCORL1 BAZ1B DIDO1 RPS25 ZHX2 HP1BP3 PHF2 SUGP2 ZNF592 UBTF TPX2 ELF2 L3MBTL3 HSPA4 NPAT	9.08e-08	1429	98	18	35140242
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	AMER1 NOP56 SPEF2 PCLO DACT2 DNAJC21 ABCC5 RPS25 SH3D21 HP1BP3 AHNAK SCN4A EIF5B RIMS2 CDC27 RAI1 PHTF1 MYBPC2	1.04e-07	1442	98	18	35575683
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	TMA16 NOP56 BAZ1B DIDO1 RPS25 LYAR DHX9 LIG1 SUGP2 ZNF592 UBTF AHNAK TPX2 HSPA4 DNMT1	1.17e-07	989	98	15	36424410
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	DHX16 NOP56 BAZ1B DIDO1 RPS25 LYAR AP3B1 HP1BP3 DHX9 PHF2 LIG1 AHNAK EIF5B CDC27 MAP2K3 HSPA4 DNMT1	1.56e-07	1318	98	17	30463901
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	DHX16 BAZ1B DIDO1 LYAR HP1BP3 DHX9 SUGP2 ZNF532 ZNF592 UBTF AHNAK TPX2 EIF5B MAP2K3 DNMT1	1.61e-07	1014	98	15	32416067
Pubmed	Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.	SCN4A SCN5A SCN8A	2.16e-07	5	98	3	17724025
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	DHX16 BAZ1B DIDO1 DHX9 LIG1 SUGP2 ZNF592 MAP4K1 TPX2 EIF5B ELF2 PRG4 DNMT1	2.81e-07	774	98	13	15302935
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	NOP56 BAZ1B AP3B1 HP1BP3 PHF2 ZNF592 UBTF TPX2 EIF5B CDC27 DNMT1	3.33e-07	533	98	11	30554943
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	TMA16 MYL3 NOP56 DNAJC21 RPS25 LYAR SHC3 HP1BP3 DHX9 UBTF AHNAK TPX2 EIF5B MAP2K3	4.49e-07	949	98	14	36574265
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	DHX16 TMA16 BAZ1B LYAR HP1BP3 SUGP2 UBTF EIF5B	5.92e-07	251	98	8	28077445
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	NOP56 LYAR LIG1 ZNF592 UBTF AHNAK TPX2 L3MBTL3 LCOR DNMT1	8.78e-07	469	98	10	27634302
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	SIN3B PCLO BCORL1 RPS25 DHX9 SAMD9L ZNF592 AHNAK SCN8A PRG4 RAI1 IQCE	1.14e-06	736	98	12	29676528
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	MAFK APC PHF2 SUGP2 ZNF592 UBTF EIF5B ELF2 L3MBTL3 LCOR RAI1 PHTF1 DNMT1	1.14e-06	877	98	13	20211142
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	NOP56 BAZ1B RPS25 LYAR HP1BP3 DHX9 ZNF296 SUGP2 ZNF592 UBTF RAI1	1.15e-06	605	98	11	28977666
Pubmed	BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.	BAZ1B HP1BP3 DHX9 DNMT1	1.76e-06	31	98	4	23086144
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN4A SCN5A SCN8A	1.80e-06	9	98	3	16382098
Pubmed	Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.	SCN4A SCN5A SCN8A	1.80e-06	9	98	3	15746173
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	SIN3B NOP56 BAZ1B DIDO1 HP1BP3 SUGP2 UBTF AHNAK TPX2 EIF5B ELF2 HSPA4 DNMT1	2.28e-06	934	98	13	33916271
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	DHX16 TMA16 NOP56 BAZ1B DNAJC21 DIDO1 RPS25 LYAR HP1BP3 DHX9 UBTF AHNAK TPX2 EIF5B DNMT1	2.37e-06	1257	98	15	36526897
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	DHX16 BAZ1B DIDO1 HP1BP3 SUGP2 UBTF AHNAK EIF5B HSPA4 RAI1 DNMT1	2.40e-06	653	98	11	22586326
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	AMER1 NOP56 APC RPS25 LYAR HP1BP3 DHX9 ZNF592 AHNAK EIF5B CDC27 HSPA4	3.02e-06	809	98	12	32129710
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	MAP4K3 SH3KBP1 MAP4K1 TPX2 RIMS2 CDC27 PRG4 GABRA3	4.43e-06	329	98	8	17474147
Pubmed	Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.	DHX16 HP1BP3 DHX9 ZNF592 UBTF EIF5B CDC27 HSPA4 DNMT1	4.54e-06	441	98	9	31239290
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	NOP56 BAZ1B RPS25 HP1BP3 DHX9 UBTF AHNAK MYO1F	5.63e-06	340	98	8	29478914
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DHX16 NOP56 MAP4K3 BAZ1B RPS25 LYAR DHX9 SUGP2 UBTF AHNAK EIF5B CDC27 MAP2K3 HSPA4 DNMT1	5.78e-06	1353	98	15	29467282
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	NOP56 APC DNAJC21 RPS25 AP3B1 SUGP2 AHNAK EIF5B CDC27 MAP2K3 LCOR	6.40e-06	724	98	11	36232890
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	DHX16 TMA16 NOP56 DIDO1 LYAR AP3B1 SHC3 HP1BP3 PHF2 SUGP2 AHNAK TPX2 TRPM1 GNL1 DNMT1	6.77e-06	1371	98	15	36244648
Pubmed	Suppression of intestinal neoplasia by DNA hypomethylation.	APC DNMT1	7.86e-06	2	98	2	7537636
Pubmed	SIM2 maintains innate host defense of the small intestine.	APC SIM2	7.86e-06	2	98	2	25277798
Pubmed	Complete genetic suppression of polyp formation and reduction of CpG-island hypermethylation in Apc(Min/+) Dnmt1-hypomorphic Mice.	APC DNMT1	7.86e-06	2	98	2	11888894
Pubmed	Regulatory mechanism of transforming growth factor beta receptor type II degradation by interleukin-1 in primary chondrocytes.	TGFBR2 IL1B	7.86e-06	2	98	2	22425785
Pubmed	AMER1 regulates the distribution of the tumor suppressor APC between microtubules and the plasma membrane.	AMER1 APC	7.86e-06	2	98	2	17925383
Pubmed	Suppressing TGFβ signaling in regenerating epithelia in an inflammatory microenvironment is sufficient to cause invasive intestinal cancer.	APC TGFBR2	7.86e-06	2	98	2	25687406
Pubmed	Mouse heart Na+ channels: primary structure and function of two isoforms and alternatively spliced variants.	SCN4A SCN5A	7.86e-06	2	98	2	11834499
Pubmed	Suppressive effect of global DNA hypomethylation on gastric carcinogenesis.	APC DNMT1	7.86e-06	2	98	2	20622006
Pubmed	Elevated circulating TGFβ1 during acute liver failure activates TGFβR2 on cortical neurons and exacerbates neuroinflammation and hepatic encephalopathy in mice.	TGFBR2 IL1B	7.86e-06	2	98	2	30940161
Pubmed	Reducing DNA methylation suppresses colon carcinogenesis by inducing tumor cell differentiation.	APC DNMT1	7.86e-06	2	98	2	25939752
Pubmed	Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation.	APC TGFBR2	7.86e-06	2	98	2	17047044
Pubmed	Unifying roles for regulatory T cells and inflammation in cancer.	RAG2 APC	7.86e-06	2	98	2	19795459
Pubmed	Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice.	APC DNMT1	7.86e-06	2	98	2	12538347
Pubmed	Human DNA methyltransferase gene DNMT1 is regulated by the APC pathway.	APC DNMT1	7.86e-06	2	98	2	12538344
Pubmed	Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif.	SCN4A SCN5A	7.86e-06	2	98	2	30944319
Pubmed	Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis.	APC DNMT1	7.86e-06	2	98	2	16174748
Pubmed	The Shc family protein adaptor, Rai, acts as a negative regulator of Th17 and Th1 cell development.	SHC3 RAI1	7.86e-06	2	98	2	23345394
Pubmed	Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice.	RAG2 IL1B	7.86e-06	2	98	2	18977329
Pubmed	Helicobacter hepaticus infection promotes colon tumorigenesis in the BALB/c-Rag2(-/-) Apc(Min/+) mouse.	RAG2 APC	7.86e-06	2	98	2	18411292
Pubmed	ApcMin/+ mouse model of colon cancer: gene expression profiling in tumors.	APC DNMT1	7.86e-06	2	98	2	15486983
Pubmed	Escherichia coli-induced temporal and differential secretion of heat-shock protein 70 and interleukin-1β by human fetal membranes in a two-compartment culture system.	IL1B HSPA4	7.86e-06	2	98	2	25600910
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	SIN3B APC ZNF385B DHX9 SCN8A EIF5B GNL1 HSPA4 DNMT1	8.24e-06	475	98	9	31040226
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DHX16 TMA16 NOP56 APC DIDO1 RPS25 LYAR HP1BP3 DHX9 PHF2 SUGP2 ZNF532 EIF5B	1.11e-05	1082	98	13	38697112
Pubmed	NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency.	NOP56 BAZ1B ZNF592 UBTF RAI1	1.13e-05	103	98	5	32744500
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	AHI1 AMER1 NOP56 MAP4K3 APC BAZ1B DIDO1 AP3B1 UBTF CDC27 LRRC18 LRRC71 NPAT	1.13e-05	1084	98	13	11544199
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	NOP56 PCLO AP3B1 HP1BP3 DHX9 SUGP2 AHNAK EIF5B GNL1	1.20e-05	498	98	9	36634849
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	AMER1 APC ABCC5 AP3B1 HP1BP3 DHX9 LIG1 SUGP2 AHNAK IQCE DNMT1	1.24e-05	777	98	11	35844135
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	NOP56 BCORL1 PHF2 ZNF592 AHNAK TPX2 ELF2 L3MBTL3 LCOR RAI1	1.45e-05	645	98	10	25281560
Pubmed	Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.	NOP56 MAFK BAZ1B DIDO1 RPS25 LYAR HP1BP3 DHX9 AHNAK TPX2	1.59e-05	652	98	10	31180492
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	DHX16 BAZ1B DIDO1 DHX9 SUGP2 TPX2 DNMT1	1.61e-05	283	98	7	30585729
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	DHX16 NOP56 BAZ1B LYAR AP3B1 DHX9 TPX2 CDC27 GNL1 DNMT1	1.62e-05	653	98	10	33742100
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	NOP56 DIDO1 LYAR AP3B1 DHX9 AHNAK TPX2 RAI1	1.64e-05	394	98	8	27248496
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	NOP56 PCLO RPS25 AP3B1 HP1BP3 DHX9 DNAH1 AHNAK SCN8A EIF5B HSPA4	1.76e-05	807	98	11	30575818
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	MAFK BAZ1B DIDO1 PHF2 ZNF296 ZNF592 UBTF ELF2 LCOR PHTF1 DNMT1	1.78e-05	808	98	11	20412781
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SIN3B TMA16 NOA1 APC BAZ1B DNAJC21 DIDO1 LYAR AP3B1 ZHX2 PHF2 ZNF592 TPX2 EIF5B CDC27	1.91e-05	1497	98	15	31527615
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DIDO1 NUAK1 ZNF532 ZNF592 RIMS2 L3MBTL3 LCOR RAI1 IQCE	1.93e-05	529	98	9	14621295
Pubmed	ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing.	MYL3 APC TGFBR2 SCN5A	2.09e-05	57	98	4	23788249
Pubmed	PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.	TMA16 NOP56 NOA1 RPS25 LYAR DHX9 SUGP2 EIF5B HSPA4 NPAT	2.23e-05	678	98	10	30209976
Pubmed	Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress.	APC NUAK1	2.35e-05	3	98	2	29500295
Pubmed	Stat3 is indispensable for damage-induced crypt regeneration but not for Wnt-driven intestinal tumorigenesis.	APC TGFBR2	2.35e-05	3	98	2	30156908
Pubmed	TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway.	APC TGFBR2	2.35e-05	3	98	2	19208363
Pubmed	Prostate cancer induced by loss of Apc is restrained by TGFβ signaling.	APC TGFBR2	2.35e-05	3	98	2	24651496
Pubmed	Reduction of pancreatic acinar cell tumor multiplicity in Dnmt1 hypomorphic mice.	APC DNMT1	2.35e-05	3	98	2	21362628
Pubmed	Correlation between the expression of DNMT1, and GSTP1 and APC, and the methylation status of GSTP1 and APC in association with their clinical significance in prostate cancer.	APC DNMT1	2.35e-05	3	98	2	25738352
Pubmed	Patient Mutation Directed shRNA Screen Uncovers Novel Bladder Tumor Growth Suppressors.	TGFBR2 SAMD9L	2.35e-05	3	98	2	26078295
Pubmed	ADGB variants cause asthenozoospermia and male infertility.	SPEF2 ADGB	2.35e-05	3	98	2	36995441
Pubmed	Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents.	SCN4A SCN5A	2.35e-05	3	98	2	20038812
Pubmed	Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor β Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation.	APC TGFBR2	2.35e-05	3	98	2	27835699
Pubmed	PARP1, DIDO3, and DHX9 Proteins Mutually Interact in Mouse Fibroblasts, with Effects on DNA Replication Dynamics, Senescence, and Oncogenic Transformation.	DIDO1 DHX9	2.35e-05	3	98	2	38247850
Pubmed	Modulation of skeletal and cardiac voltage-gated sodium channels by calmodulin.	SCN4A SCN5A	2.35e-05	3	98	2	15746172
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	SIN3B BCORL1 APC ZNF532 ZNF592 AHNAK L3MBTL3 NPAT	2.50e-05	418	98	8	34709266
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	SIN3B NOP56 BAZ1B DIDO1 AP3B1 SUGP2 AHNAK TPX2 DNMT1	2.58e-05	549	98	9	38280479
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	NOP56 APC ABCC5 RPS25 AP3B1 DHX9 AHNAK EIF5B CDC27 HSPA4	3.21e-05	708	98	10	39231216
Pubmed	Identification of 14-3-3epsilon substrates from embryonic murine brain.	AHI1 RAB11FIP2 NUAK1 RIMS2 HSPA4	3.74e-05	132	98	5	16944949
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	DHX16 NOP56 PCLO BAZ1B RPS25 LYAR PRDM7 AP3B1 DHX9 PHF2 UBTF EIF5B HSPA4 DNMT1	4.61e-05	1425	98	14	30948266
Pubmed	TGFβ engages MEK/ERK to differentially regulate benign and malignant pancreas cell function.	APC TGFBR2	4.70e-05	4	98	2	28368414
Pubmed	Intestinal cancer progression by mutant p53 through the acquisition of invasiveness associated with complex glandular formation.	APC TGFBR2	4.70e-05	4	98	2	28628120
Pubmed	T cell receptor (TCR) and transforming growth factor β (TGF-β) signaling converge on DNA (cytosine-5)-methyltransferase to control forkhead box protein 3 (foxp3) locus methylation and inducible regulatory T cell differentiation.	RAG2 DNMT1	4.70e-05	4	98	2	23687305
Pubmed	Dnmt1N/+ reduces the net growth rate and multiplicity of intestinal adenomas in C57BL/6-multiple intestinal neoplasia (Min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of Min 1(AKR) resistance allele.	APC DNMT1	4.70e-05	4	98	2	10919675
Pubmed	CIN85 modulates TGFβ signaling by promoting the presentation of TGFβ receptors on the cell surface.	SH3KBP1 TGFBR2	4.70e-05	4	98	2	26169354
Pubmed	PHF2 regulates sarcomeric gene transcription in myogenesis.	PHF2 MYBPC2	4.70e-05	4	98	2	38701072
Pubmed	Adenomatous polyposis coli (APC) membrane recruitment 3, a member of the APC membrane recruitment family of APC-binding proteins, is a positive regulator of Wnt-β-catenin signalling.	AMER1 APC	4.70e-05	4	98	2	24251807
Pubmed	Nuclear DNA helicase II (RNA helicase A) binds to an F-actin containing shell that surrounds the nucleolus.	DHX9 UBTF	4.70e-05	4	98	2	14729462
Pubmed	Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1.	LIG1 DNMT1	4.70e-05	4	98	2	36928068
Pubmed	'Default' generated neonatal regulatory T cells are hypomethylated at conserved non-coding sequence 2 and promote long-term cardiac allograft survival.	RAG2 DNMT1	4.70e-05	4	98	2	24944101
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	NOP56 BAZ1B LYAR HP1BP3 SUGP2 RAI1 DNMT1	6.11e-05	349	98	7	25665578
Interaction	ZNF330 interactions	DHX16 NOP56 BCORL1 BAZ1B LYAR HP1BP3 PHF2 ZNF592 UBTF ELF2 CDC27 L3MBTL3 LCOR RAI1 DNMT1	4.04e-09	446	98	15	int:ZNF330
Interaction	H3C3 interactions	SIN3B TMA16 BCORL1 BAZ1B DIDO1 LYAR HP1BP3 PHF2 UBTF TPX2 ELF2 CDC27 RAI1 DNMT1 NPAT	1.63e-08	495	98	15	int:H3C3
Interaction	SMC5 interactions	NOP56 BCORL1 BAZ1B DIDO1 RPS25 LYAR HP1BP3 DHX9 PHF2 SUGP2 UBTF AHNAK TPX2 EIF5B ELF2 L3MBTL3 LCOR RAI1 DNMT1 NPAT	5.83e-08	1000	98	20	int:SMC5
Interaction	CENPA interactions	NOP56 BCORL1 BAZ1B LYAR HP1BP3 PHF2 UBTF ELF2 L3MBTL3 LCOR RAI1 DNMT1	2.95e-07	377	98	12	int:CENPA
Interaction	H3-3A interactions	DHX16 TMA16 BCORL1 BAZ1B DIDO1 LYAR HP1BP3 PHF2 ZNF592 UBTF TPX2 ELF2 CDC27 RAI1 DNMT1 NPAT	6.23e-07	749	98	16	int:H3-3A
Interaction	H2BC8 interactions	DHX16 BCORL1 BAZ1B DIDO1 LYAR HP1BP3 PHF2 ZNF592 UBTF TPX2 ELF2 L3MBTL3 RAI1 DNMT1	7.45e-07	576	98	14	int:H2BC8
Interaction	BRD2 interactions	NOP56 BAZ1B LYAR ELOF1 HP1BP3 PHF2 LIG1 ZNF592 UBTF CDC27 LCOR DNMT1	1.16e-06	429	98	12	int:BRD2
Interaction	NCL interactions	NOP56 RAB11FIP2 DIDO1 RPS25 LYAR DHX9 ENAM BNC1 PNMA8A EIF5B CDC27 MAP2K3 PRG4 GNL1 HSPA4 ADAP2	1.43e-06	798	98	16	int:NCL
Interaction	CEBPA interactions	SIN3B TMA16 NOP56 MAFK BCORL1 DIDO1 RPS25 HP1BP3 PHF2 LIG1 SUGP2 UBTF TPX2 EIF5B ELF2 L3MBTL3 LCOR HSPA4 RAI1 DNMT1	1.88e-06	1245	98	20	int:CEBPA
Interaction	APEX1 interactions	DHX16 AHI1 NOP56 CCDC28B BCORL1 BAZ1B DIDO1 LYAR HP1BP3 PHF2 LIG1 UBTF AHNAK TPX2 ELF2 MAP2K3 L3MBTL3 LCOR RAI1 DNMT1	2.59e-06	1271	98	20	int:APEX1
Interaction	ASF1A interactions	NOP56 BCORL1 PHF2 ZNF592 TPX2 ELF2 LCOR RAI1 NPAT	3.51e-06	249	98	9	int:ASF1A
Interaction	HECTD1 interactions	NOP56 APC BAZ1B DNAJC21 DIDO1 RPS25 LYAR HP1BP3 DHX9 SUGP2 UBTF PNMA8A TPX2 CDC27 L3MBTL3 HSPA4 DNMT1	4.84e-06	984	98	17	int:HECTD1
Interaction	BRD3 interactions	NOP56 BAZ1B LYAR HP1BP3 PHF2 ZNF592 UBTF TPX2 EIF5B CDC27 RAI1 DNMT1	4.95e-06	494	98	12	int:BRD3
Interaction	H2BC21 interactions	PCLO BCORL1 BAZ1B DNAJC21 DIDO1 HP1BP3 PHF2 MAP4K1 AHNAK TPX2 CDC27 L3MBTL3 LCOR RAI1	6.73e-06	696	98	14	int:H2BC21
Interaction	KLF16 interactions	SIN3B NOP56 BAZ1B ZHX2 HP1BP3 UBTF TPX2 ELF2 L3MBTL3 HSPA4 NPAT	6.96e-06	425	98	11	int:KLF16
Interaction	PYHIN1 interactions	DHX16 TMA16 BAZ1B LYAR HP1BP3 SUGP2 UBTF EIF5B RAI1 DNMT1	9.66e-06	358	98	10	int:PYHIN1
Interaction	H2BC9 interactions	NOA1 PCLO BAZ1B DNAJC21 ZNF385B REEP2 DNAH1 AHNAK TRPM1 RAI1 DNMT1	1.10e-05	446	98	11	int:H2BC9
Interaction	TERF2IP interactions	DHX16 DIDO1 HP1BP3 SUGP2 ZNF592 UBTF TPX2 ELF2 HSPA4 RAI1 DNMT1 NPAT	1.51e-05	552	98	12	int:TERF2IP
Interaction	KCNA3 interactions	NOP56 SPEF2 APC ABCC5 RPS25 AP3B1 SHC3 DHX9 UBTF AHNAK EIF5B TRPM1 CDC27 HSPA4 PHTF1	1.95e-05	871	98	15	int:KCNA3
Interaction	POLR1G interactions	DHX16 NOP56 BCORL1 LYAR PHF2 LIG1 ZNF592 UBTF ELF2 LCOR RAI1	2.57e-05	489	98	11	int:POLR1G
Interaction	RNF123 interactions	SIN3B PCLO BCORL1 GRIK1 RPS25 DHX9 SAMD9L ZNF592 AHNAK SCN8A PRG4 LCOR RAI1 IQCE	4.39e-05	824	98	14	int:RNF123
Interaction	SIRT7 interactions	DHX16 NOP56 BAZ1B DIDO1 LYAR HP1BP3 SUGP2 UBTF AHNAK EIF5B HSPA4 RAI1 DNMT1	6.35e-05	744	98	13	int:SIRT7
Interaction	CBX3 interactions	DHX16 AMER1 BCORL1 BAZ1B HP1BP3 LIG1 UBTF TPX2 EIF5B ELF2 LCOR DNMT1	6.97e-05	646	98	12	int:CBX3
Interaction	MYCN interactions	SYNPO2 TMA16 NOP56 NOA1 BAZ1B DNAJC21 DIDO1 RPS25 LYAR HP1BP3 DHX9 SUGP2 UBTF EIF5B ELF2 HSPA4 RAI1 DNMT1	9.91e-05	1373	98	18	int:MYCN
Interaction	OBSL1 interactions	DHX16 TMA16 NOP56 PCLO PAK5 BAZ1B GRIK1 HP1BP3 DHX9 DNAH1 SUGP2 UBTF AHNAK EIF5B	1.15e-04	902	98	14	int:OBSL1
Interaction	SCN8A interactions	SCN4A SCN5A SCN8A	1.20e-04	20	98	3	int:SCN8A
Interaction	DCPS interactions	NOP56 BAZ1B RPS25 HP1BP3 DHX9 UBTF AHNAK MYO1F CDC27	1.29e-04	394	98	9	int:DCPS
Interaction	NR2C2 interactions	DHX16 NOP56 BAZ1B DIDO1 RPS25 LYAR AP3B1 HP1BP3 DHX9 PHF2 LIG1 AHNAK EIF5B ELF2 CDC27 MAP2K3 HSPA4 DNMT1	1.30e-04	1403	98	18	int:NR2C2
Interaction	AURKA interactions	SIN3B AMER1 PAK5 ELOF1 DHX9 LIG1 SUGP2 UBTF TPX2 CDC27 MAP2K3 HSPA4	1.41e-04	696	98	12	int:AURKA
Interaction	SNCA interactions	NOP56 PCLO RPS25 AP3B1 HP1BP3 DHX9 SUGP2 AHNAK EIF5B GNL1 HSPA4 ADAP2	1.83e-04	716	98	12	int:SNCA
Interaction	NUP43 interactions	NOP56 APC ZHX2 HP1BP3 PHF2 ZNF532 ZNF592 UBTF ELF2 LCOR NPAT	2.27e-04	625	98	11	int:NUP43
Interaction	FBXW7 interactions	DHX16 TMA16 NOP56 BAZ1B DNAJC21 DIDO1 RPS25 LYAR HP1BP3 DHX9 SUGP2 UBTF MAP4K1 AHNAK EIF5B DNMT1	2.42e-04	1215	98	16	int:FBXW7
Interaction	USP37 interactions	SIN3B RHOU PHF2 SUGP2 CDC27	2.47e-04	115	98	5	int:USP37
Interaction	HDLBP interactions	DHX16 TMA16 DIDO1 LYAR AP3B1 SHC3 DHX9 PHF2 SUGP2 AHNAK TPX2 TRPM1 DNMT1	2.52e-04	855	98	13	int:HDLBP
Interaction	NAA40 interactions	DHX16 SIN3B NOP56 BAZ1B DIDO1 HP1BP3 SUGP2 UBTF AHNAK TPX2 EIF5B ELF2 HSPA4 DNMT1	2.66e-04	978	98	14	int:NAA40
Interaction	LHX2 interactions	BCORL1 BAZ1B ZHX2 PHF2 ELF2 L3MBTL3	2.72e-04	183	98	6	int:LHX2
Interaction	CHD3 interactions	SIN3B NOP56 BAZ1B RPS25 LYAR HP1BP3 DHX9 ZNF296 SUGP2 ZNF592 UBTF RAI1	3.04e-04	757	98	12	int:CHD3
Interaction	POLR1E interactions	NOP56 BCORL1 LYAR PHF2 ZNF592 UBTF EIF5B LCOR	3.09e-04	350	98	8	int:POLR1E
Interaction	RPS6 interactions	NOP56 NOA1 PCLO RPS25 LYAR HP1BP3 DHX9 PHF2 UBTF TPX2 EIF5B MAP2K3 HSPA4	3.12e-04	874	98	13	int:RPS6
Interaction	L3MBTL3 interactions	LIG1 DPPA4 ELF2 L3MBTL3 DNMT1	3.37e-04	123	98	5	int:L3MBTL3
Interaction	ING2 interactions	SIN3B TARS3 AHNAK ELF2	3.37e-04	68	98	4	int:ING2
Interaction	UTP23 interactions	BAZ1B LYAR AP3B1 HP1BP3 DHX9 UBTF	3.42e-04	191	98	6	int:UTP23
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN4A SCN5A SCN8A	3.34e-06	9	63	3	1203
GeneFamily	Mitogen-activated protein kinase kinase kinase kinases	MAP4K3 MAP4K1	1.19e-04	5	63	2	655
GeneFamily	Zinc fingers\|Zinc fingers PARP-type\|Poly(ADP-ribose) polymerases	PCLO LYAR	1.22e-03	15	63	2	26
GeneFamily	DEAH-box helicases	DHX16 DHX9	1.39e-03	16	63	2	500
GeneFamily	PDZ domain containing	SYNPO2 PCLO AHNAK RIMS2	1.95e-03	152	63	4	1220
GeneFamily	PHD finger proteins	BAZ1B DIDO1 PHF2	3.82e-03	90	63	3	88
Coexpression	GSE369_PRE_VS_POST_IL6_INJECTION_IFNG_KO_LIVER_UP	APC AP3B1 MAP4K1 AHNAK MYO1F RAI1 DNMT1 GABRA3	8.74e-07	200	98	8	M5973
Coexpression	PUJANA_ATM_PCC_NETWORK	DHX16 NOP56 APC BAZ1B DIDO1 GRIK1 RPS25 SIM2 AP3B1 ZHX2 DHX9 MAP4K1 EIF5B HSPA4 DNMT1 MYBPC2 NPAT	1.51e-05	1394	98	17	M9585
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	AHI1 OXR1 PCLO PAK5 ZNF385B SCN8A RIMS2 PHTF1	1.37e-08	198	98	8	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH3KBP1 APC BAZ1B HP1BP3 DHX9 SAMD9L AHNAK	1.72e-07	184	98	7	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	AHI1 OXR1 PCLO PAK5 ZNF385B SCN8A RIMS2	2.65e-07	196	98	7	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	H1299-infected-SARSCoV2\|infected / Cell line, Condition and Strain	AHI1 NOP56 LYAR AHNAK EIF5B RIMS2 DNMT1	2.74e-07	197	98	7	0fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	AHI1 OXR1 PCLO PAK5 ZNF385B SCN8A RIMS2	2.83e-07	198	98	7	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	AHI1 OXR1 PCLO PAK5 ZNF385B SCN8A RIMS2	2.83e-07	198	98	7	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	AHI1 OXR1 PCLO PAK5 ZNF385B SCN8A RIMS2	2.83e-07	198	98	7	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	AHI1 OXR1 PCLO PAK5 ZNF385B SCN8A RIMS2	2.83e-07	198	98	7	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	AHI1 OXR1 PCLO PAK5 ZNF385B SCN8A RIMS2	3.03e-07	200	98	7	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-late_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAG2 GRIK1 REEP2 ELOF1 LIG1 DPPA4	2.41e-06	174	98	6	021ebc6ec022b992d7b25333ba0b7416371e041b
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-late_pro_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAG2 GRIK1 REEP2 ELOF1 LIG1 DPPA4	2.41e-06	174	98	6	c2fc78dd6c440737ded59676961e4c7b923084ce
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Mesenchymal-Mes-Myofibroblast\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DACT2 TGFBR2 SSC5D SAMD9L AHNAK SCN4A	2.74e-06	178	98	6	1802ff1c6cb18ee62cfef7270c0971048fae5315
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Mesenchymal-Mes-Myofibroblast-VLMC_L1-3_CYP1B1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DACT2 TGFBR2 SSC5D SAMD9L AHNAK SCN4A	2.74e-06	178	98	6	4368d20130e5a08716564c19470b6014f16902ac
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal-6\|World / Primary Cells by Cluster	PDE1A PCLO PAK5 APC NUAK1 RIMS2	5.21e-06	199	98	6	1b1bccf4293f11048709d15a3c892c0edf3da3d2
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal\|World / Primary Cells by Cluster	PDE1A PCLO PAK5 APC NUAK1 RIMS2	5.21e-06	199	98	6	4bee94c116c0da5eba951cb4cea7cc9dcdd6e30f
ToppCell	H1299\|World / Cell line, Condition and Strain	NOP56 BAZ1B RPS25 LYAR SUGP2 DNMT1	5.36e-06	200	98	6	23f08d7cffacfced48785cd3ad230ecadb95713f
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c4-RSAD2\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CMTM2 APC SAMD9L DENND6B CDC27	2.46e-05	156	98	5	f5889a6899904dfb7f596600b3a76857cf9d5378
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma\|TCGA-Brain / Sample_Type by Project: Shred V9	CDHR1 RAB11FIP2 SHC3 RIMS2 GABRA3	2.86e-05	161	98	5	5f6b2d7f80a8ee16651e304481d2da3fae313824
ToppCell	PND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NOP56 SH3KBP1 LIG1 TRPM1 DNMT1	3.51e-05	168	98	5	ade02beb8d663fce4be2aefa10392ab849a4bbe7
ToppCell	3'-GW_trimst-1-SmallIntestine-Hematopoietic-B_cells-Pre-B\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RAG2 ENAM ZNF296 MAP4K1 MYO1F	4.50e-05	177	98	5	ecd26d086c1aff3be442fcb055611a563ca034ef
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SPEF2 DNAH1 ADGB DENND6B LRRC71	4.62e-05	178	98	5	3b12db04006db6e94fc45649a4b3a63b92f21a61
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	PCLO DACT2 GRIK1 SIM2 RIMS2	4.75e-05	179	98	5	06f92c884189197c86793191c05f65e34925c097
ToppCell	11.5-Airway-Immune-Hematopoietic,_B_Cells\|Airway / Age, Tissue, Lineage and Cell class	RAG2 ENAM ZNF296 MAP4K1 SCN4A	5.00e-05	181	98	5	727344d7b2953568b7b3463398c7d56878cf2c2b
ToppCell	droplet-Marrow-nan-3m-Myeloid-nan\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAG2 SH3KBP1 DHX9 SAMD9L AHNAK	5.13e-05	182	98	5	f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Cortical_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC28B ELOF1 ZNF296 EIF5B RIMS2	5.55e-05	185	98	5	60e223cd0ed3022e3f98ce6b766bedd14c534885
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	AMER1 OXR1 APC LCOR NPAT	5.69e-05	186	98	5	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	PND03\|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SPEF2 APC AHNAK IL1B LRRC71	5.84e-05	187	98	5	b3fcb36d853adfdea7172c5591de06f027e50af3
ToppCell	Int-URO-Lymphocyte-T_NK-T_NK_proliferative\|Int-URO / Disease, Lineage and Cell Type	CCDC28B CDHR1 LIG1 TPX2 SCN8A	6.30e-05	190	98	5	005967c540418b85311308072a07c684f4296aef
ToppCell	facs-Lung-nan-3m-Mesenchymal-pulmonary_interstitial_fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE1A SYNPO2 ZNF385B RHOU SSC5D	6.30e-05	190	98	5	c7bd087f36321cec61b98657433b4d19d135791f
ToppCell	facs-Lung-nan-3m-Mesenchymal-Myofibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE1A SYNPO2 ZNF385B RHOU SSC5D	6.30e-05	190	98	5	834218fcc59df5e7e52de154272f3d55d81d0dac
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAJC21 HP1BP3 SAMD9L UBTF LCOR	6.45e-05	191	98	5	60c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAJC21 HP1BP3 SAMD9L UBTF LCOR	6.45e-05	191	98	5	09db184cb90fe282a14474d7217068c58092c6f8
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAJC21 HP1BP3 SAMD9L UBTF LCOR	6.45e-05	191	98	5	973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCell	H1299-infected\|H1299 / Cell line, Condition and Strain	NOP56 BAZ1B HP1BP3 SUGP2 EIF5B	6.61e-05	192	98	5	9cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	PDE1A SYNPO2 ZNF385B NUAK1 GABRA3	6.61e-05	192	98	5	5c7e8b80b44d9ce55c797cdf8267ac5382e26cac
ToppCell	moderate-Epithelial-FOXN4+\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	AHI1 NOP56 LIG1 TPX2 DNMT1	6.95e-05	194	98	5	dff3fb10372053951d41e0ccd41aac3ece6009bd
ToppCell	tumor_Lung-Myeloid_cells-CD163+CD14+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	SH3KBP1 RPS25 IL1B MAP2K3 DNMT1	7.29e-05	196	98	5	7aa6778b78a8549dd4d0a5278ef8017334b00c38
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Neuroepithelial\|10w / Sample Type, Dataset, Time_group, and Cell type.	SYNPO2 SIM2 TGFBR2 SAMD9L AHNAK	8.02e-05	200	98	5	ff0b2675c68e9fc1fa16b3276431f199f3642eac
ToppCell	Sepsis-Int-URO-Lymphocyte-T/NK-T/NK_proliferative\|Int-URO / Disease, condition lineage and cell class	CCDC28B CDHR1 LIG1 TPX2 SCN8A	8.02e-05	200	98	5	99acc1ea01288efdd5b166aa20d66735f2bbe543
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Neuroepithelial-Proteoglycan-expressing_cell\|10w / Sample Type, Dataset, Time_group, and Cell type.	SYNPO2 SIM2 TGFBR2 SAMD9L AHNAK	8.02e-05	200	98	5	07d2133c85e0a4eb8bef653ee15ecd0f1b2bbd44
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN4A SCN5A SCN8A	4.06e-06	10	97	3	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN4A SCN5A SCN8A	4.06e-06	10	97	3	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN4A SCN5A SCN8A	7.42e-06	12	97	3	DOID:0060170 (implicated_via_orthology)
Disease	Malignant tumor of colon	SH3KBP1 APC TGFBR2 IL1B MAP2K3 DNMT1	1.47e-05	159	97	6	C0007102
Disease	Colonic Neoplasms	SH3KBP1 APC TGFBR2 IL1B DNMT1	1.49e-04	152	97	5	C0009375
Disease	Pleocytosis	APC IL1B	1.59e-04	6	97	2	C0151857
Disease	Leukocytosis	APC IL1B	1.59e-04	6	97	2	C0023518
Disease	Bipolar Disorder	PCLO GRIK1 ZNF592 SCN8A IL1B HSPA4 DNMT1 GABRA3	1.81e-04	477	97	8	C0005586
Disease	sunburn	RAB11FIP2 ADAM30 PRDM7 TRPM1	2.89e-04	96	97	4	EFO_0003958
Disease	Arthritis, Collagen-Induced	RAG2 IL1B DNMT1	3.11e-04	40	97	3	C0971858
Disease	Arthritis, Experimental	RAG2 IL1B DNMT1	3.11e-04	40	97	3	C0993582
Disease	Arthritis, Adjuvant-Induced	RAG2 IL1B DNMT1	3.11e-04	40	97	3	C0003865
Disease	Lynch Syndrome	APC TGFBR2	3.79e-04	9	97	2	C4552100
Disease	Childhood Medulloblastoma	APC L3MBTL3 DNMT1	3.86e-04	43	97	3	C0278510
Disease	Melanotic medulloblastoma	APC L3MBTL3 DNMT1	3.86e-04	43	97	3	C1275668
Disease	Medullomyoblastoma	APC L3MBTL3 DNMT1	3.86e-04	43	97	3	C0205833
Disease	Desmoplastic Medulloblastoma	APC L3MBTL3 DNMT1	3.86e-04	43	97	3	C0751291
Disease	Adult Medulloblastoma	APC L3MBTL3 DNMT1	3.86e-04	43	97	3	C0278876
Disease	membranoproliferative glomerulonephritis (implicated_via_orthology)	TGFBR2 IL1B	4.73e-04	10	97	2	DOID:2920 (implicated_via_orthology)
Disease	alkaline phosphatase measurement	BAZ1B AP3B1 ELOF1 HP1BP3 TREH AHNAK L3MBTL3 HSPA4 RAI1 PHTF1 DNMT1	5.06e-04	1015	97	11	EFO_0004533
Disease	Gastric cancer	APC IL1B	5.77e-04	11	97	2	cv:C0024623
Disease	cocaine use	GRIK1 HSPA4	5.77e-04	11	97	2	C3496069
Disease	Neoplasm of stomach	APC IL1B	5.77e-04	11	97	2	cv:C0038356
Disease	GASTRIC CANCER	APC IL1B	5.77e-04	11	97	2	613659
Disease	Medulloblastoma	APC L3MBTL3 DNMT1	6.03e-04	50	97	3	C0025149
Disease	Profound Mental Retardation	AHI1 APC SCN8A RAI1	1.16e-03	139	97	4	C0020796
Disease	Mental Retardation, Psychosocial	AHI1 APC SCN8A RAI1	1.16e-03	139	97	4	C0025363
Disease	Mental deficiency	AHI1 APC SCN8A RAI1	1.16e-03	139	97	4	C0917816
Disease	basophil percentage of leukocytes	AHI1 SPEF2 ABCC5 L3MBTL3 PHTF1	1.27e-03	243	97	5	EFO_0007992
Disease	Eye Abnormalities	APC TGFBR2	1.41e-03	17	97	2	C0015393
Disease	rheumatoid arthritis (is_marker_for)	IL1B HSPA4 DNMT1	1.54e-03	69	97	3	DOID:7148 (is_marker_for)
Disease	Uterine leiomyoma, estrogen-receptor positive breast cancer	HSPA4 ADAP2	1.58e-03	18	97	2	EFO_1000649, HP_0000131
Disease	cytomegalovirus virus reactivation, response to allogeneic hematopoietic stem cell transplant	PDE1A PCLO	1.76e-03	19	97	2	EFO_0007044, EFO_0020106
Disease	epilepsy (implicated_via_orthology)	DHX9 SCN4A SCN5A SCN8A	2.09e-03	163	97	4	DOID:1826 (implicated_via_orthology)
Disease	status epilepticus (implicated_via_orthology)	GRIK1 IL1B	2.16e-03	21	97	2	DOID:1824 (implicated_via_orthology)
Disease	neuroticism measurement, cognitive function measurement	PDE1A PCLO APC ZNF385B SH3D21 RAI1 MYBPC2	2.68e-03	566	97	7	EFO_0007660, EFO_0008354
Disease	carnosine measurement	OXR1 AP3B1	2.82e-03	24	97	2	EFO_0010470
Disease	Neoplasm Invasiveness	NUAK1 AHNAK IL1B DNMT1	3.23e-03	184	97	4	C0027626

Protein segments in the cluster

Peptide	Gene	Start	Entry
TKAATKFMLKEKPPN	CDHR1	761	Q96JP9
EMPSPKKMHQGKKKK	DNMT1	711	P26358
DSMQDDTKPKPKKTK	AHI1	291	Q8N157
KMTPAPDTQKKKKGK	ADGB	1651	Q8N7X0
SKSPKKGLKTPKTKM	BAZ1B	421	Q9UIG0
PSGNKDAKPLLKEMK	GRIK1	206	P39086
TESLPPKKMKCGKEK	BCORL1	1111	Q5H9F3
ALPKKKSRKSSMPIK	BNC1	531	Q01954
EKMSIKGSKVLCPKK	DPPA4	51	Q7L190
GSKLNVPKMKVPKFS	AHNAK	426	Q09666
EGKLKGSKFKMPKLN	AHNAK	1761	Q09666
GSKFKMPKLNIKAPK	AHNAK	1766	Q09666
KLKGPKFKMPDVHFK	AHNAK	4501	Q09666
KLKGPKFKMPEINIK	AHNAK	4831	Q09666
PKIHMSGPKIKAKKQ	AHNAK	5026	Q09666
GPEAKIKFPKFSMPK	AHNAK	5226	Q09666
KIKMPKFNFSKPKGK	AHNAK	5711	Q09666
AEKFPSMPKPKKGLK	AMER1	156	Q5JTC6
SMPKPKKGLKGFFSS	AMER1	161	Q5JTC6
LEDPHAKKMPKKIGK	DHX16	1021	O60231
MSGDLPKQVKLKKPS	DENND6B	356	Q8NEG7
SKRKPPPKKKMTGTL	ELOF1	6	P60002
FMEKTGPKQKEPFKK	ADAP2	261	Q9NPF8
KEKTDKKKKPYTMDP	AP3B1	281	O00203
KLPGKGKSTMKKSFR	HP1BP3	536	Q5SSJ5
PLKKPPMKSLRKKGS	RAG2	496	P55895
KRMSSPKKAKPTKGN	RAI1	1271	Q7Z5J4
PLGEKKTGAKRQKKM	IQCE	276	Q6IPM2
AFKVKPPHGFQKKMK	L3MBTL3	466	Q96JM7
IKKKKLPSSFPAGMD	NPAT	1401	Q14207
MFGKKKKKIEISGPS	PAK5	1	Q9P286
KNPAPMRKKKKVSLG	PNMA8A	356	Q86V59
VDPKNYPKKKMEKRF	IL1B	201	P01584
MTKSNFQPPKLKDKM	MAP4K3	226	Q8IVH8
MEDPSISFSKPKKKK	NOP56	496	O00567
MTTNPKPNKALKVKK	MAFK	1	O60675
SKDKKMDQPPQAKKA	HSPA4	556	P34932
MAPKKPEPKKDDAKA	MYL3	1	P08590
KEPKKPKAGKTAMNG	ELOVL4	271	Q9GZR5
KKEEPKKAQTKMSPK	PCLO	851	Q9Y6V0
KKAQTKMSPKPDAKP	PCLO	856	Q9Y6V0
GTLKNPPKKKMKLMR	LCOR	391	Q96JN0
GMTKKKPEEKPKFRS	PDE1A	106	P54750
MVKGEKGPKGKKITL	LRRC18	1	Q8N456
QTMKTPKGLGKKKEK	LRRC71	366	Q8N4P6
GKKVPEALEMKKKTP	GABRA3	371	P34903
MPRKKPFSVKQKKKQ	GNL1	1	P36915
AKSVPKPKGKKTKDM	DNAJC21	451	Q5F1R6
PPKPHKSKKGGKMRQ	RIMS2	526	Q9UQ26
MTKDKNSPGLKKKSQ	OXR1	1	Q8N573
IQNSPKLTPKMKKDK	ABCC5	506	O15440
CIMKGIKPKKVPGEK	DNAH1	2956	Q9P2D7
LKPKQEKMPLSKAKT	ADAM30	716	Q9UKF2
SLKMGPPKSKAEKIK	DACT2	486	Q5SW24
MKFLSSGKEQKPKPK	DIDO1	426	Q9BTC0
SGKEQKPKPKEKMKM	DIDO1	431	Q9BTC0
KIKKPPKVTMKTGKS	BPIFB6	316	Q8NFQ5
DSHEPMKKKKVGRKP	ELF2	166	Q15723
DSKKKKMKLPEHPEG	LYAR	281	Q9NX58
KQEKTAQMKPPKPTK	KIAA1210	1636	Q9ULL0
SFPKLDNLVPKGKMK	ENAM	11	Q9NRM1
MDDKKKKRSPKPCLA	CCDC28B	1	Q9BUN5
MSFFHPKKEGKAKKP	LIG1	6	P18858
ENSKKLKMKFPPKIP	CDC27	391	P30260
MPPKNKEKGKKSGAQ	CCDC153	1	Q494R4
KPPSLMYNVRKKKGK	NOA1	681	Q8NC60
MTHFVPPPKDKKKKD	DHX9	581	Q08211
SMPQSKGKSKRKKDL	MAP2K3	11	P46734
LLPPKKEKMKRKGCA	MAP4K1	471	Q92918
PPSQSQDKDMKKKKM	TARS3	101	A2RTX5
VTPKPKTKSVLKGKM	SPEF2	1221	Q9C093
KSPQMGANKKVKKEP	SPEF2	1291	Q9C093
EKVSKKKTPKTVKMP	PHF2	486	O75151
LTKMEPPKKGKATKS	PHF2	556	O75151
NAMKKLGSKKPQKPI	SCN4A	1321	P35499
PKKLMPKTSLPTVKK	SH3D21	146	A4FU49
KKKGKLKPEQLTCMP	SAMD9L	151	Q8IVG5
ENPKKGLLSEMKKKG	SLC35G2	51	Q8TBE7
EKKKGPSKATVKAMQ	EIF5B	331	O60841
AVMTKPKVKRSKKGP	PRDM7	476	Q9NQW5
IKKEMKKDPLTNKAP	SH3KBP1	56	Q96B97
NAMKKLGSKKPQKPI	SCN5A	1496	Q14524
KGAFKKRKPPSKMLS	SHC3	196	Q92529
KPKNTKMKTKLRTNP	SIM2	371	Q14190
PAKKKMKLRGTKDLS	SIN3B	281	O75182
AASPKCIMKEKKKPG	TGFBR2	116	P37173
PKQSATMPKKGILKK	NUAK1	456	O60285
TTTKAPGKMPKSTKK	SSC5D	616	A1L4H1
MPPKDDKKKKDAGKS	RPS25	1	P62851
KAPKKPTSTKKPKTM	PRG4	1026	Q92954
AMPKGKSHKPFRVKK	APC	1731	P25054
AMPKKKKPSRLKGDN	APC	2046	P25054
KKAKKHMLVPPPGKE	CMTM2	206	Q8TAZ6
QPKKSKSRTPDKMKN	RHOU	231	Q7L0Q8
EKLEKKSPSPVKKSM	ZNF532	1001	Q9HCE3
KSPSPVKKSMETKKV	ZNF532	1006	Q9HCE3
DMGDKAPKRAKPIKK	REEP2	211	Q9BRK0
QPSKMGKKKGKKPLN	SYNPO2	946	Q9UMS6
GKKKGKKPLNALDVM	SYNPO2	951	Q9UMS6
LKNKPKKMGHIKPDL	PHTF1	36	Q9UMS5
KESSKGSPKMPKSPK	ZNF592	316	Q92610
RPMSKKKKPKDLDFA	SUGP2	991	Q8IX01
KKLGKKMKPEVLSHP	TREH	136	O43280
AMKKLGSKKPQKPIP	SCN8A	1491	Q9UQD0
SSGEIQMKSKPKKPF	RAB11FIP2	201	Q7L804
TKNKPKMVPSKDSAK	ZNF385B	191	Q569K4
KATEKEKKPPMATTK	TRPM1	411	Q7Z4N2
IMKPGKPKADAKKVP	ZHX2	186	Q9Y6X8
NSSKKMKFQGEPKKP	UBTF	556	P17480
MPKAPKGKSAGREKK	TMA16	1	Q96EY4
SQKASPKKMPKSGGK	ZNF296	366	Q8WUU4
PSKKMKVSNNKKKPE	TPX2	156	Q9ULW0
KSSKPTRKGMAKGKP	MYO1F	921	O00160
MPEAKPAAKKAPKGK	MYBPC2	1	Q14324