Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionTRAIL receptor activity

TNFRSF10B TNFRSF10A

2.58e-054422GO:0036463
GeneOntologyMolecularFunctionTRAIL binding

TNFRSF10B TNFRSF10A

4.30e-055422GO:0045569
GeneOntologyMolecularFunctionnuclear receptor activity

NR6A1 NR1I3 VDR

2.72e-0460423GO:0004879
GeneOntologyMolecularFunctionligand-activated transcription factor activity

NR6A1 NR1I3 VDR

2.86e-0461423GO:0098531
GeneOntologyMolecularFunctionpeptidase activator activity

TNFRSF10B TNFRSF10A PSME4

4.29e-0470423GO:0016504
GeneOntologyMolecularFunctiondeath receptor activity

TNFRSF10B TNFRSF10A

8.84e-0421422GO:0005035
GeneOntologyMolecularFunctioncysteine-type endopeptidase activator activity involved in apoptotic process

TNFRSF10B TNFRSF10A

1.69e-0329422GO:0008656
GeneOntologyMolecularFunctionpeptidase regulator activity

TNFRSF10B TNFRSF10A PSME4 SLPI

2.04e-03257424GO:0061134
GeneOntologyMolecularFunctionpeptidase activator activity involved in apoptotic process

TNFRSF10B TNFRSF10A

2.06e-0332422GO:0016505
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor binding

LRP2 DKK1

2.32e-0334422GO:0050750
GeneOntologyMolecularFunctionlipoprotein particle receptor binding

LRP2 DKK1

3.05e-0339422GO:0070325
GeneOntologyMolecularFunctionmolecular function activator activity

WNT10A TNFRSF10B TNFRSF10A PSME4 DNAJC10 DKK1 DEFB109B CCN3

3.72e-031233428GO:0140677
GeneOntologyMolecularFunctioncysteine-type endopeptidase regulator activity involved in apoptotic process

TNFRSF10B TNFRSF10A

5.77e-0354422GO:0043028
MousePhenodecreased cellular sensitivity to gamma-irradiation

ATM TNFRSF10B TNFRSF10A

2.14e-0522353MP:0003207
MousePhenoabnormal myeloid leukocyte morphology

RNF216 NCAM2 PLAT CHD7 ATM SBF1 SUCO ALG1L2 FBXO28 ZFAND2B CCN3 VDR

4.10e-0512923512MP:0008250
MousePhenodecreased cellular sensitivity to ionizing radiation

ATM TNFRSF10B TNFRSF10A

5.57e-0530353MP:0004228
DomainVitD_rcpt

NR6A1 NR1I3 VDR

3.51e-0614413IPR000324
DomainTNFR_10

TNFRSF10B TNFRSF10A

2.81e-054412IPR020465
Domainzf-C4

NR6A1 NR1I3 VDR

1.40e-0446413PF00105
DomainZnf_hrmn_rcpt

NR6A1 NR1I3 VDR

1.40e-0446413IPR001628
DomainNuclear_hrmn_rcpt

NR6A1 NR1I3 VDR

1.40e-0446413IPR001723
DomainNUCLEAR_REC_DBD_2

NR6A1 NR1I3 VDR

1.40e-0446413PS51030
DomainNUCLEAR_REC_DBD_1

NR6A1 NR1I3 VDR

1.40e-0446413PS00031
DomainZnF_C4

NR6A1 NR1I3 VDR

1.40e-0446413SM00399
Domain-

NR6A1 NR1I3 VDR

1.49e-04474131.10.565.10
DomainHOLI

NR6A1 NR1I3 VDR

1.59e-0448413SM00430
DomainNucl_hrmn_rcpt_lig-bd

NR6A1 NR1I3 VDR

1.59e-0448413IPR000536
DomainHormone_recep

NR6A1 NR1I3 VDR

1.59e-0448413PF00104
Domain-

NR6A1 NR1I3 VDR

2.65e-04574133.30.50.10
DomainZnf_NHR/GATA

NR6A1 NR1I3 VDR

2.79e-0458413IPR013088
DomainTYR_PHOSPHATASE_dom

PTPN12 SBF1 PTPRH

9.16e-0487413IPR000387
DomainTNFR_c6

TNFRSF10B TNFRSF10A

1.06e-0322412PF00020
Domain-

TNFRSF10B TNFRSF10A NLRP8

1.11e-03934131.10.533.10
DomainDEATH-like_dom

TNFRSF10B TNFRSF10A NLRP8

1.33e-0399413IPR011029
DomainTNFR

TNFRSF10B TNFRSF10A

1.48e-0326412SM00208
DomaincEGF

LRP2 FBLN5

1.48e-0326412IPR026823
DomaincEGF

LRP2 FBLN5

1.48e-0326412PF12662
DomainDEATH

TNFRSF10B TNFRSF10A

1.59e-0327412SM00005
DomainTNFR_NGFR_1

TNFRSF10B TNFRSF10A

1.84e-0329412PS00652
DomainTNFR_NGFR_2

TNFRSF10B TNFRSF10A

1.84e-0329412PS50050
DomainDeath

TNFRSF10B TNFRSF10A

2.38e-0333412PF00531
DomainTNFR/NGFR_Cys_rich_reg

TNFRSF10B TNFRSF10A

2.38e-0333412IPR001368
DomainPTPc

PTPN12 PTPRH

2.83e-0336412SM00194
DomainDeath_domain

TNFRSF10B TNFRSF10A

3.14e-0338412IPR000488
DomainDEATH_DOMAIN

TNFRSF10B TNFRSF10A

3.14e-0338412PS50017
DomainTYR_PHOSPHATASE_PTP

PTPN12 PTPRH

3.31e-0339412PS50055
DomainPTPase_domain

PTPN12 PTPRH

3.65e-0341412IPR000242
DomainY_phosphatase

PTPN12 PTPRH

3.65e-0341412PF00102
DomainGrowth_fac_rcpt_

LRP2 FBLN5 CCN3

4.83e-03156413IPR009030
DomainTyr_Pase_AS

PTPN12 PTPRH

1.12e-0273412IPR016130
PathwayKEGG_MEDICUS_REFERENCE_TNFSF10_RIPK1_3_SIGNALING_PATHWAY

TNFRSF10B TNFRSF10A

4.66e-055312M49027
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_CELL_DEATH_GENES

ATM TNFRSF10B TNFRSF10A

1.20e-0444313M27499
PathwayREACTOME_TRAIL_SIGNALING

TNFRSF10B TNFRSF10A

1.30e-048312M27711
PathwayREACTOME_TRAIL_SIGNALING

TNFRSF10B TNFRSF10A

1.30e-048312MM15449
PathwayREACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY

NR6A1 NR1I3 VDR

1.56e-0448313MM14987
PathwayREACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY

NR6A1 NR1I3 VDR

2.09e-0453313M8276
PathwayPID_P53_DOWNSTREAM_PATHWAY

TNFRSF10B TNFRSF10A DKK1 VDR

2.19e-04137314M145
PathwayREACTOME_REGULATION_BY_C_FLIP

TNFRSF10B TNFRSF10A

2.54e-0411312M27249
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_DEATH_RECEPTORS_AND_LIGANDS

TNFRSF10B TNFRSF10A

3.05e-0412312M27631
PathwayREACTOME_VITAMIN_D_CALCIFEROL_METABOLISM

LRP2 VDR

3.05e-0412312M27088
PathwayREACTOME_REGULATION_BY_C_FLIP

TNFRSF10B TNFRSF10A

3.60e-0413312MM14947
PathwayREACTOME_CASPASE_ACTIVATION_VIA_DEATH_RECEPTORS_IN_THE_PRESENCE_OF_LIGAND

TNFRSF10B TNFRSF10A

5.51e-0416312M26947
PathwayWP_DRUG_INDUCTION_OF_BILE_ACID_PATHWAY

NR1I3 VDR

6.24e-0417312M39666
PathwayREACTOME_CASPASE_ACTIVATION_VIA_DEATH_RECEPTORS_IN_THE_PRESENCE_OF_LIGAND

TNFRSF10B TNFRSF10A

7.82e-0419312MM14555
PathwayKEGG_APOPTOSIS

ATM TNFRSF10B TNFRSF10A

9.01e-0487313M8492
PathwayREACTOME_CASPASE_ACTIVATION_VIA_EXTRINSIC_APOPTOTIC_SIGNALLING_PATHWAY

TNFRSF10B TNFRSF10A

1.15e-0323312MM15176
Pubmed

Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.

LRP2 PGM2L1 CHD7 TNFRSF10B TNFRSF10A NANS CCN3

9.21e-0831342720800603
Pubmed

Tat-induced FOXO3a is a key mediator of apoptosis in HIV-1-infected human CD4+ T lymphocytes.

ATM TNFRSF10B TNFRSF10A

2.68e-071142319050264
Pubmed

Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric carcinoma and tumor-infiltrating lymphocytes: a possible mechanism of immune evasion of the tumor.

TNFRSF10B TNFRSF10A

1.42e-06242211862476
Pubmed

Expression quantitative trait loci for TNFRSF10 influence both HBV infection and hepatocellular carcinoma development.

TNFRSF10B TNFRSF10A

1.42e-06242226297860
Pubmed

TRAIL-receptor preferences in pancreatic cancer cells revisited: Both TRAIL-R1 and TRAIL-R2 have a licence to kill.

TNFRSF10B TNFRSF10A

1.42e-06242226138346
Pubmed

Prediction of proapoptotic anticancer therapeutic response in vivo based on cell death visualization and TRAIL death ligand-receptor interaction.

TNFRSF10B TNFRSF10A

1.42e-06242221785270
Pubmed

A positive feedback signaling loop between ATM and the vitamin D receptor is critical for cancer chemoprevention by vitamin D.

ATM VDR

1.42e-06242222207345
Pubmed

Hypoxia/reoxygenation up-regulates death receptor expression and enhances apoptosis in human biliary epithelial cells.

TNFRSF10B TNFRSF10A

1.42e-06242219643115
Pubmed

TRAIL-induced apoptosis and expression of death receptor TRAIL-R1 and TRAIL-R2 in bladder cancer cells.

TNFRSF10B TNFRSF10A

1.42e-06242220430723
Pubmed

Vitamin D Receptor and Megalin Gene Polymorphisms Are Associated with Longitudinal Cognitive Change among African-American Urban Adults.

LRP2 VDR

1.42e-06242228446629
Pubmed

Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein.

NR1I3 VDR

1.42e-06242215905360
Pubmed

The role of TRAIL death receptors in the treatment of hematological malignancies.

TNFRSF10B TNFRSF10A

1.42e-06242218203008
Pubmed

TRAIL induces apoptosis but not necroptosis in colorectal and pancreatic cancer cells preferentially via the TRAIL-R2/DR5 receptor.

TNFRSF10B TNFRSF10A

1.42e-06242229278689
Pubmed

Case-control study of vitamin D, dickkopf homolog 1 (DKK1) gene methylation, VDR gene polymorphism and the risk of colon adenoma in African Americans.

DKK1 VDR

1.42e-06242222022386
Pubmed

TRAIL-receptor expression is an independent prognostic factor for survival in patients with a primary glioblastoma multiforme.

TNFRSF10B TNFRSF10A

1.42e-06242216544055
Pubmed

Expression of tumor necrosis factor-related apoptosis-inducing ligand death receptors DR4 and DR5 in human nonmelanoma skin cancer.

TNFRSF10B TNFRSF10A

1.42e-06242224212133
Pubmed

Modulation of TRAIL resistance in colon carcinoma cells: different contributions of DR4 and DR5.

TNFRSF10B TNFRSF10A

1.42e-06242221272366
Pubmed

Epigenetic Modification of Death Receptor Genes for TRAIL and TRAIL Resistance in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia.

TNFRSF10B TNFRSF10A

1.42e-06242234198757
Pubmed

Characterization of 8p21.3 chromosomal deletions in B-cell lymphoma: TRAIL-R1 and TRAIL-R2 as candidate dosage-dependent tumor suppressor genes.

TNFRSF10B TNFRSF10A

1.42e-06242216051735
Pubmed

Plumbagin enhances TRAIL-mediated apoptosis through up-regulation of death receptor in human melanoma A375 cells.

TNFRSF10B TNFRSF10A

1.42e-06242220714870
Pubmed

Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses.

TNFRSF10B TNFRSF10A

1.42e-06242223498957
Pubmed

TRAIL and immunity: more than a license to kill tumor cells.

TNFRSF10B TNFRSF10A

1.42e-06242215608691
Pubmed

Expression of tumor necrosis factor--related apoptosis-inducing ligand receptors 1 and 2 in melanoma.

TNFRSF10B TNFRSF10A

1.42e-06242216778114
Pubmed

Real-time imaging of the dynamics of death receptors and therapeutics that overcome TRAIL resistance in tumors.

TNFRSF10B TNFRSF10A

1.42e-06242222824792
Pubmed

Vitamin D receptor and megalin gene polymorphisms and their associations with longitudinal cognitive change in US adults.

LRP2 VDR

1.42e-06242222170372
Pubmed

8p21.3 deletion suggesting a probable role of TRAIL-R1 and TRAIL-R2 as candidate tumor suppressor genes in the pathogenesis of multiple myeloma.

TNFRSF10B TNFRSF10A

1.42e-06242223423784
Pubmed

Differential regulation of the TRAIL death receptors DR4 and DR5 by the signal recognition particle.

TNFRSF10B TNFRSF10A

1.42e-06242215356269
Pubmed

Loss of TRAIL-receptors is a recurrent feature in pancreatic cancer and determines the prognosis of patients with no nodal metastasis after surgery.

TNFRSF10B TNFRSF10A

1.42e-06242223460812
Pubmed

TRAIL receptor mediates inflammatory cytokine release in an NF-kappaB-dependent manner.

TNFRSF10B TNFRSF10A

1.42e-06242219434100
Pubmed

Secretory stressors induce intracellular death receptor accumulation to control apoptosis.

TNFRSF10B TNFRSF10A

1.42e-06242228981087
Pubmed

[Associations of Crohn's disease with DR4 and DR5 gene polymorphisms].

TNFRSF10B TNFRSF10A

1.42e-06242226418999
Pubmed

Human normal hepatocytes are susceptible to apoptosis signal mediated by both TRAIL-R1 and TRAIL-R2.

TNFRSF10B TNFRSF10A

1.42e-06242214576771
Pubmed

Efficacy of triple therapies including ionising radiation, agonistic TRAIL antibodies and cisplatin.

TNFRSF10B TNFRSF10A

1.42e-06242219424623
Pubmed

CD95 and TRAIL receptor-mediated activation of protein kinase C and NF-kappaB contributes to apoptosis resistance in ductal pancreatic adenocarcinoma cells.

TNFRSF10B TNFRSF10A

1.42e-06242211464292
Pubmed

Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through the DR4 receptor by competing for ligand binding.

TNFRSF10B TNFRSF10A

1.42e-06242217666396
Pubmed

Prostatic compensation of the vitamin D axis in African American men.

LRP2 VDR

1.42e-06242228138564
Pubmed

Concurrent Mutations in ATM and Genes Associated with Common γ Chain Signaling in Peripheral T Cell Lymphoma.

ATM WDR17

1.42e-06242226536348
Pubmed

Human embryonic and induced pluripotent stem cells express TRAIL receptors and can be sensitized to TRAIL-induced apoptosis.

TNFRSF10B TNFRSF10A

1.42e-06242223806100
Pubmed

TRAIL signaling is mediated by DR4 in pancreatic tumor cells despite the expression of functional DR5.

TNFRSF10B TNFRSF10A

4.27e-06342220354842
Pubmed

A Genome-Wide Loss-of-Function Screen Identifies SLC26A2 as a Novel Mediator of TRAIL Resistance.

TNFRSF10B TNFRSF10A

4.27e-06342228108622
Pubmed

Down-regulation of Cbl-b by bufalin results in up-regulation of DR4/DR5 and sensitization of TRAIL-induced apoptosis in breast cancer cells.

TNFRSF10B TNFRSF10A

4.27e-06342222447040
Pubmed

Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells.

TNFRSF10B TNFRSF10A

4.27e-06342215480430
Pubmed

Adenovirus RIDbeta subunit contains a tyrosine residue that is critical for RID-mediated receptor internalization and inhibition of Fas- and TRAIL-induced apoptosis.

TNFRSF10B TNFRSF10A

4.27e-06342212388693
Pubmed

[Effect of tumor necrosis factor-related apoptosis-inducing ligand on developing human oligodendrocytes in culture].

TNFRSF10B TNFRSF10A

4.27e-06342225845236
Pubmed

c-Cbl-mediated degradation of TRAIL receptors is responsible for the development of the early phase of TRAIL resistance.

TNFRSF10B TNFRSF10A

4.27e-06342219932172
Pubmed

Mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in activated T cells abrogates TRAIL-induced apoptosis upstream of the mitochondrial amplification loop and caspase-8.

TNFRSF10B TNFRSF10A

4.27e-06342212218097
Pubmed

Increased expression of TRAIL and its death receptors DR4 and DR5 in plaque psoriasis.

TNFRSF10B TNFRSF10A

4.27e-06342221279373
Pubmed

Involvement of tumor necrosis factor-related apoptosis-inducing ligand and tumor necrosis factor-related apoptosis-inducing ligand receptors in viral hepatic diseases.

TNFRSF10B TNFRSF10A

4.27e-06342216226105
Pubmed

The TRAIL system is over-expressed in breast cancer and FLIP a marker of good prognosis.

TNFRSF10B TNFRSF10A

4.27e-06342225230899
Pubmed

Expression of tumor necrosis factor- alpha -related apoptosis-inducing ligand and its proapoptotic receptors is down-regulated during gastric infection with virulent cagA+/vacAs1+ Helicobacter pylori strains.

TNFRSF10B TNFRSF10A

4.27e-06342215655781
Pubmed

Alpha-tocopheryl succinate induces DR4 and DR5 expression by a p53-dependent route: implication for sensitisation of resistant cancer cells to TRAIL apoptosis.

TNFRSF10B TNFRSF10A

4.27e-06342216529749
Pubmed

The expression of TRAIL and its receptors in gastric cancer and the apoptotic effect of rh-TRAIL on SGC7901 cells.

TNFRSF10B TNFRSF10A

4.27e-06342219212626
Pubmed

FLIP overexpression inhibits death receptor-induced apoptosis in malignant mesothelial cells.

TNFRSF10B TNFRSF10A

4.27e-06342215334061
Pubmed

Death receptor-dependent and -independent pathways in anticancer drug-induced apoptosis of breast cancer cells.

TNFRSF10B TNFRSF10A

4.27e-06342214534720
Pubmed

An HPLC method associated with a thermodynamic analysis to compare the binding of TRAIL and its nanovectorized form to death receptors DR4 and DR5 and their relationship to cytotoxicity.

TNFRSF10B TNFRSF10A

4.27e-06342227750195
Pubmed

Profiles of Wnt pathway gene expression during tooth morphogenesis.

WNT10A DKK1

4.27e-06342238274045
Pubmed

Death receptor 5 is activated by fucosylation in colon cancer cells.

TNFRSF10B TNFRSF10A

4.27e-06342230589515
Pubmed

Tuberculosis risk is associated with genetic polymorphisms in the LRP2, CUBN, and VDR genes.

LRP2 VDR

4.27e-06342232803705
Pubmed

Heterogeneous intracellular TRAIL-receptor distribution predicts poor outcome in breast cancer patients.

TNFRSF10B TNFRSF10A

4.27e-06342231183506
Pubmed

Activated Cdc42-associated kinase 1 (Ack1) is required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor recruitment to lipid rafts and induction of cell death.

TNFRSF10B TNFRSF10A

4.27e-06342224085293
Pubmed

IG20 (MADD splice variant-5), a proapoptotic protein, interacts with DR4/DR5 and enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the DISC.

TNFRSF10B TNFRSF10A

4.27e-06342215208670
Pubmed

Expression of TRAIL and the death receptors DR4 and DR5 correlates with progression of degeneration in human intervertebral disks.

TNFRSF10B TNFRSF10A

4.27e-06342219305384
Pubmed

Characterization of two receptors for TRAIL.

TNFRSF10B TNFRSF10A

4.27e-0634229373179
Pubmed

Mutational analysis of death receptor genes Fas, TRAILR1 and TRAILR2 in prostate carcinomas.

TNFRSF10B TNFRSF10A

4.27e-06342220666744
Pubmed

[Mechanism of leukemia cell apoptosis induced by sodium butyrate activating TRAIL pathway].

TNFRSF10B TNFRSF10A

4.27e-06342219379558
Pubmed

A novel receptor for Apo2L/TRAIL contains a truncated death domain.

TNFRSF10B TNFRSF10A

4.27e-0634229382840
Pubmed

Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis.

TNFRSF10B TNFRSF10A

4.27e-06342216319225
Pubmed

Anti-cancer effect of bee venom on colon cancer cell growth by activation of death receptors and inhibition of nuclear factor kappa B.

TNFRSF10B TNFRSF10A

4.27e-06342226561202
Pubmed

Prognostic significance of TRAIL death receptors in Middle Eastern colorectal carcinomas and their correlation to oncogenic KRAS alterations.

TNFRSF10B TNFRSF10A

4.27e-06342220673328
Pubmed

Redistribution of DR4 and DR5 in lipid rafts accounts for the sensitivity to TRAIL in NSCLC cells.

TNFRSF10B TNFRSF10A

4.27e-06342221769428
Pubmed

TRAIL-R1 and TRAIL-R2 Mediate TRAIL-Dependent Apoptosis in Activated Primary Human B Lymphocytes.

TNFRSF10B TNFRSF10A

4.27e-06342231114586
Pubmed

Death receptors 4 and 5 activate Nox1 NADPH oxidase through riboflavin kinase to induce reactive oxygen species-mediated apoptotic cell death.

TNFRSF10B TNFRSF10A

4.27e-06342222158615
Pubmed

The C-terminal tails of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas receptors have opposing functions in Fas-associated death domain (FADD) recruitment and can regulate agonist-specific mechanisms of receptor activation.

TNFRSF10B TNFRSF10A

4.27e-06342215452120
Pubmed

Hepatitis C virus triggers apoptosis of a newly developed hepatoma cell line through antiviral defense system.

TNFRSF10B TNFRSF10A

4.27e-06342217983809
Pubmed

TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.

TNFRSF10B TNFRSF10A

4.27e-0634229311998
Pubmed

Disturbed expression of vitamin D and retinoic acid-related orphan receptors α and γ and of megalin in inflammatory skin diseases.

LRP2 VDR

4.27e-06342234995387
Pubmed

Association of a single nucleotide polymorphism in the constitutive androstane receptor gene with bone mineral density.

NR1I3 VDR

4.27e-06342219702932
Pubmed

H-Ras regulation of TRAIL death receptor mediated apoptosis.

TNFRSF10B TNFRSF10A

4.27e-06342225026275
Pubmed

TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB.

TNFRSF10B TNFRSF10A

4.27e-0634229430228
Pubmed

Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5.

TNFRSF10B TNFRSF10A

4.27e-06342210549288
Pubmed

Comparative binding to DR4 and DR5 receptors of TRAIL and BNNTs/PAHE/mPEG-DSPE/TRAIL nanoparticles.

TNFRSF10B TNFRSF10A

4.27e-06342228120533
Pubmed

TRAIL death receptors DR4 and DR5 mediate cerebral microvascular endothelial cell apoptosis induced by oligomeric Alzheimer's Aβ.

TNFRSF10B TNFRSF10A

4.27e-06342222695614
Pubmed

TRAIL resistance of breast cancer cells is associated with constitutive endocytosis of death receptors 4 and 5.

TNFRSF10B TNFRSF10A

4.27e-06342219074831
Pubmed

Protein kinase C modulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by targeting the apical events of death receptor signaling.

TNFRSF10B TNFRSF10A

4.27e-06342212920112
Pubmed

Microsatellite instability, KRAS mutations and cellular distribution of TRAIL-receptors in early stage colorectal cancer.

TNFRSF10B TNFRSF10A

4.27e-06342223284732
Pubmed

Expression and prognostic value of FAS receptor/FAS ligand and TrailR1/TrailR2 in acute myeloid leukemia.

TNFRSF10B TNFRSF10A

8.53e-06442222183068
Pubmed

DDIT3 and KAT2A Proteins Regulate TNFRSF10A and TNFRSF10B Expression in Endoplasmic Reticulum Stress-mediated Apoptosis in Human Lung Cancer Cells.

TNFRSF10B TNFRSF10A

8.53e-06442225770212
Pubmed

Alveolar epithelial cells in idiopathic pulmonary fibrosis display upregulation of TRAIL, DR4 and DR5 expression with simultaneous preferential over-expression of pro-apoptotic marker p53.

TNFRSF10B TNFRSF10A

8.53e-06442224551275
Pubmed

Death receptor 5 contributes to cardiomyocyte hypertrophy through epidermal growth factor receptor transactivation.

TNFRSF10B TNFRSF10A

8.53e-06442231473246
Pubmed

Endoplasmic Reticulum Stress Activated by Androgen Enhances Apoptosis of Granulosa Cells via Induction of Death Receptor 5 in PCOS.

TNFRSF10B TNFRSF10A

8.53e-06442230423122
Pubmed

TRAIL receptor upregulation and the implication of KRAS/BRAF mutations in human colon cancer tumors.

TNFRSF10B TNFRSF10A

8.53e-06442219637313
Pubmed

Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane.

TNFRSF10B TNFRSF10A

8.53e-06442218165900
Pubmed

HPV upregulates MARCHF8 ubiquitin ligase and inhibits apoptosis by degrading the death receptors in head and neck cancer.

TNFRSF10B TNFRSF10A

8.53e-06442236867660
Pubmed

TRAIL receptor deficiency sensitizes mice to dextran sodium sulphate-induced colitis and colitis-associated carcinogenesis.

TNFRSF10B TNFRSF10A

8.53e-06442224117005
Pubmed

Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy.

TNFRSF10B TNFRSF10A

8.53e-06442214769851
Pubmed

Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism: evidence for the role of the ROS-ERK-CHOP-death receptor pathway.

TNFRSF10B TNFRSF10A

8.53e-06442224078627
Pubmed

TNFRSF10A downregulation induces retinal pigment epithelium degeneration during the pathogenesis of age-related macular degeneration and central serous chorioretinopathy.

TNFRSF10B TNFRSF10A

8.53e-06442235103281
Pubmed

Membrane expression of TRAIL receptors DR4, DR5, DcR1 and DcR2 in the normal endometrium, atypical endometrial hyperplasia and endometrioid adenocarcinoma: a tissue microarray study.

TNFRSF10B TNFRSF10A

8.53e-06442223584885
Pubmed

The murine TRAIL receptor signals caspase-independent cell death through ceramide.

TNFRSF10B TNFRSF10A

8.53e-06442217026999
Pubmed

Membrane expression of the death ligand trail receptors DR4 and DR5 in the normal endometrium, endometrial atypical hyperplasia and endometrioid endometrial cancer.

TNFRSF10B TNFRSF10A

8.53e-06442223815209
Cytoband2q35

WNT10A ZFAND2B

2.41e-03794222q35
CytobandEnsembl 112 genes in cytogenetic band chr21q21

NCAM2 CYYR1

5.63e-03122422chr21q21
CytobandEnsembl 112 genes in cytogenetic band chr2q35

WNT10A ZFAND2B

6.27e-03129422chr2q35
CytobandEnsembl 112 genes in cytogenetic band chr8p21

TNFRSF10B TNFRSF10A

6.84e-03135422chr8p21
GeneFamilyNuclear hormone receptors

NR6A1 NR1I3 VDR

8.78e-054932371
GeneFamilyCD molecules|Tumor necrosis factor receptor superfamily|Death inducing signaling complex

TNFRSF10B TNFRSF10A

1.20e-0329322782
CoexpressionRAMJAUN_APOPTOSIS_BY_TGFB1_VIA_SMAD4_DN

ATM TNFRSF10B TNFRSF10A

1.00e-0613413MM505
CoexpressionGALI_TP53_TARGETS_APOPTOTIC_DN

TNFRSF10B TNFRSF10A

3.57e-056412M17309
CoexpressionDESERT_STEM_CELL_HEPATOCELLULAR_CARCINOMA_SUBCLASS_UP

CHD7 PTPN12 DKK1 ATP11B SUCO

3.68e-05242415M34034
CoexpressionSENESE_HDAC1_AND_HDAC2_TARGETS_UP

PTPN12 TNFRSF10B PSME4 DKK1 ATP11B

3.75e-05243415M18938
CoexpressionMIKI_COEXPRESSED_WITH_CYP19A1

NR6A1 VDR

4.99e-057412M1868
ToppCellControl-Endothelial-Endothelial-Artery|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADCY4 FBLN5 TNFRSF10A CCN3 CYYR1

8.60e-071864252d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCellLPS_only-Endothelial-Endothelial-Vein|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PLAT ADCY4 TNFRSF10B SLPI CYYR1

1.01e-0619242552acaecd3703166f5ce3b328aff7c82bd142fee4
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ADCY4 FBLN5 TNFRSF10A CYYR1

1.24e-051514243b4c57bad61e17a573e6f8dc6b917fba5fd56c43
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-DC-DC1-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NR1I3 RGS13 VDR CYYR1

1.79e-05166424c8a7d94ed762e5e045ab5f74eef691ddc5f74993
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD8-Tem/emra_CD8|GI_small-bowel / Manually curated celltypes from each tissue

LRP2 DNAH9 VDR SLPI

2.01e-05171424f28684ea0e74a22f4c140658496068e28a6d3605
ToppCellClub-club-3|World / Class top

PLAT NANS MYO5C SLPI

2.06e-0517242434fbb82a2ec77dd183cf26b38edeb7e936b707bc
ToppCellAdult-Endothelial-endothelial_cell_of_bronchial_vessel|Adult / Lineage, Cell type, age group and donor

PLAT ADCY4 TNFRSF10A CYYR1

2.06e-05172424ad4ffdb3fc0c560a9cbaa2bc048476cbc43e8fd6
ToppCellCD8+_Memory_T_cell-FLU-5|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

WNT10A FBLN5 NR6A1 VDR

2.41e-051794247f18dffa85285599662edbcd3f32ab42672bffb8
ToppCelldroplet-Kidney-nan-21m-Endothelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLAT ADCY4 FBLN5 CYYR1

2.41e-05179424ba38177ffcf3a20f02afeeaaa91bc8eab8d1ac05
ToppCelldroplet-Kidney-nan-21m-Endothelial-kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLAT ADCY4 FBLN5 CYYR1

2.41e-05179424d121351b4c3b91108e6c5753d18a44d676f38d4c
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NCAM2 PLAT CHD7 CCN3

2.52e-05181424a436e7e4c36403257ea90160a58ca0d6d7c0cdfc
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-mesothelial_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP2 WNT10A DKK1 SLPI

2.63e-05183424c5caac6ed6c8d67f5c336281d9fd903976509445
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP2 WNT10A DKK1 SLPI

2.63e-051834249d5a363fbe6f0a1668c9d584df65ee1c283349c7
ToppCellnormal_Lung-Myeloid_cells-pDCs|Myeloid_cells / Location, Cell class and cell subclass

RNF216 PGM2L1 SUCO CYYR1

2.86e-05187424a3592f056e1c2f82ba325fea2ecc4dd6c6347c81
ToppCelldroplet-Kidney-nan-18m-Endothelial|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLAT ADCY4 FBLN5 CYYR1

2.92e-05188424ca3be1942b179b512ab242acded31f1e3748c753
ToppCelldroplet-Kidney-KIDNEY-30m-Endothelial|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLAT ADCY4 FBLN5 CYYR1

2.98e-0518942492319bef1f00d6048ba8f9f8b5c6dbb896686b74
ToppCelldroplet-Pancreas-PANCREAS-30m-Endothelial-endothelial_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PLAT ADCY4 TNFRSF10B CYYR1

3.04e-051904249d5242759546be0089981ef1877e4ed5f81face5
ToppCellCOVID-19-Heart-EC_3|Heart / Disease (COVID-19 only), tissue and cell type

PLAT ADCY4 MYO5C CYYR1

3.04e-0519042478e7c502b0450c0b37652b1896a2a752fd8a2111
ToppCellPND01-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLAT ADCY4 FBLN5 CYYR1

3.04e-051904243346bfd0474828b3729cffa9f4cc57b04dd30443
ToppCellfacs-MAT-Fat-18m-Endothelial-endothelial_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADCY4 TNFRSF10B NR1I3 CYYR1

3.04e-051904249aaa48f3aad813c87a45efdbb67d255c94f6e6a4
ToppCellfacs-MAT-Fat-18m-Endothelial|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADCY4 TNFRSF10B NR1I3 CYYR1

3.04e-0519042434e56c5e7ea6a8f227dbaefe73cbb8818d18b523
ToppCellfacs-MAT-Fat-18m-Endothelial-nan|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADCY4 TNFRSF10B NR1I3 CYYR1

3.04e-0519042414cdb660ad3aabcf49572173e7628d8b99dcbe6f
ToppCellPND01-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLAT ADCY4 FBLN5 CYYR1

3.04e-05190424eae5bcdb8a35f3fba4d25854c1a43f83f80832a2
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-mesothelial_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP2 WNT10A DKK1 SLPI

3.10e-051914245343a527de6b0f852f45020a91f5b4869e78f13a
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP2 WNT10A DKK1 SLPI

3.10e-05191424a25a5f9a380031fdaf57677a079f97a90f0550c0
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NCAM2 PLAT ADCY4 CYYR1

3.17e-0519242425cb6cc6cbf8dc20139d938adfc02ed7a8c3dfb6
ToppCellLPS-antiTNF-Endothelial-Endothelial-Activated_Gen_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ADCY4 TNFRSF10B TNFRSF10A CYYR1

3.17e-051924240aeb5351275c0a91151ea2d52b2cdde172da6731
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PLAT ADCY4 CCN3 CYYR1

3.23e-051934243a9fe4e709c09ec787c71bdd6b58a71c419896de
ToppCell3'-Child09-12-SmallIntestine-Endothelial-blood_vessel_EC|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLAT ADCY4 CCN3 CYYR1

3.43e-05196424a0ba408b802fa6d6e42e6d234b6879fdb1583f81
ToppCell5'-Adult-LargeIntestine-Endothelial-blood_vessel_EC-arterial_capillary|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLAT ADCY4 CCN3 CYYR1

3.50e-05197424c29ed0e706999d4c2b93e6e3bf46c42aeceb4813
ToppCell3'-Child09-12-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLAT ADCY4 CCN3 CYYR1

3.50e-05197424947042f888335c0829d4d5daeb623973eadb3348
ToppCell3'-Child04-06-SmallIntestine-Endothelial-blood_vessel_EC|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLAT ADCY4 CCN3 CYYR1

3.57e-0519842499be7a7a84199dac598e993a5a0144d9030f13ce
ToppCellTracheal-NucSeq-Endothelial-Endothelia_vascular-VE_systemic_venous|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PLAT ADCY4 TNFRSF10B CYYR1

3.57e-051984245c82dad416938d5c460069796d808170e7dbc8d9
ToppCell3'-Child04-06-SmallIntestine-Endothelial|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLAT ADCY4 CCN3 CYYR1

3.57e-05198424bf4e086c3fc924e999b6eaca87d2beee9b9526c2
ToppCell(6)_Endothelial_cells-(6)_Endothelial-A_(Artery)|(6)_Endothelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

PLAT TNFRSF10B NANS CYYR1

3.64e-05199424fc68b42b25efc985d9204b1ab372fad10fddafe7
ToppCell3'-Child04-06-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PLAT ADCY4 CCN3 CYYR1

3.64e-0519942457709dc893da8d9333830b8277a6d92e25aa8bc0
ToppCellILEUM-non-inflamed-(7)_Endothelial_cell|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PLAT ADCY4 CCN3 CYYR1

3.72e-05200424ec92fe4eafe527d351ee73c9735e96855ac506a3
ToppCellILEUM-non-inflamed-(7)_CD36+_endothelial_cells|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PLAT ADCY4 CCN3 CYYR1

3.72e-0520042445755a597725015dc3ee36f9166f9e82f6f9c603
ToppCellThalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2|Thalamus / BrainAtlas - Mouse McCarroll V32

ADCY4 ZFAND2B CYYR1

2.66e-0413342329b0c2c682c6b97823e7d8d8ba1f5114044b30ba
ToppCellThalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Pi16_(Pi16)|Thalamus / BrainAtlas - Mouse McCarroll V32

ADCY4 FBLN5 ZFAND2B

3.23e-0414242358bfff3284ae21150e4619511bd58622c16c5dde
ToppCellThalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Pi16_(Pi16)--|Thalamus / BrainAtlas - Mouse McCarroll V32

ADCY4 FBLN5 ZFAND2B

3.23e-041424235fd737c1fee9d97aee8955f1bf378ead3fce138d
ToppCellThalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Pi16_(Pi16)-|Thalamus / BrainAtlas - Mouse McCarroll V32

ADCY4 FBLN5 ZFAND2B

3.23e-0414242316f9945e835c3506b12d904778560d065a50f059
ToppCellChildren_(3_yrs)-Immune-mast_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

PLAT RGS13 GFRA3

3.50e-04146423f7349d63bb47f1f22ced8ff514edc1c11bc782e7
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PLAT FBXO28 RGS13

3.86e-041514239ebfbdccc9656fce8990d06622f225009633f07c
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PLAT FBXO28 RGS13

3.86e-0415142329d91a7d1470121af45fb8bb35175f2acced4551
ToppCellP15-Epithelial-epithelial_progenitor_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

GFRA3 MYO5C SLPI

3.94e-0415242300d5503d462cfa009fb4cac79ecee11725a18b9a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FBLN5 DKK1 CCN3

4.17e-0415542382e602f31981c6b48abff2a04b2ab5d26d4462a2
ToppCellP28-Epithelial-epithelial_progenitor_cell-epi_progenitor|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LRP2 MYO5C SLPI

4.17e-04155423be575a0096415705dba425002247289ff8f89474
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FBLN5 DKK1 CCN3

4.17e-04155423979c1d53b435a82c57d16707eed8ba7346326866
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_dendritic-liver_dendritic_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TNFRSF10B VDR CYYR1

4.25e-04156423411c170a7dd65269ae442b8069caf5231bddb116
ToppCell5'-Adult-Appendix-Hematopoietic-B_cells-Cycling_B_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ATM DNAJC10 RGS13

4.25e-04156423203ef22eb76bd2b829b027c30af0557080f4006c
ToppCellBAL-Mild-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PLAT RBM44 RGS13

4.25e-041564235d9e1df70f2e9219f6b029be2e39297605d36726
ToppCell367C-Lymphocytic-ILC|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

NCAM2 ALG1L2 NR1I3

4.33e-04157423f511871e1a004c6e9af08ee325ab1bfc41807487
ToppCellChildren_(3_yrs)-Immune-mast_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

PLAT RGS13 GFRA3

4.33e-04157423ec185dbeabb67fd9ca85f71cab88463b60f9b1c1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 WDR17 DNAH9

4.58e-04160423c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellCOVID-19-kidney-Epithelial_(EC)|kidney / Disease (COVID-19 only), tissue and cell type

PLAT ADCY4 CYYR1

4.58e-041604230d4880f85565d8c540c94a8f8109147b3029279a
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 WDR17 DNAH9

4.58e-0416042325c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.4.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRP2 TNFRSF10A RGS13

4.66e-041614231f4614ae15bd2fc08e555cea4d0152c4a940d048
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-Plasma_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

WNT10A ATM ATP11B

4.75e-041624238ed9149ff53b285591354057055d072b203a47c8
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-CytoT_GZMK+-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PGM2L1 ADCY4 ATM

4.75e-0416242319395bdb282b4a2d88cd33191af12c24a88c3d16
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-Plasma_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

WNT10A ATM ATP11B

4.75e-041624237a05b05a33e1309fb5c0a8171db105ae68491815
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mast-Mast|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TNFRSF10A PTPRH RGS13

4.75e-0416242330508c4007faa38b76246e3c6d7b3fde4492cc85
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mast|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TNFRSF10A PTPRH RGS13

4.75e-0416242333b73c6727b5c5ada2dddf304f56d84397725ca8
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mast-Mast-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TNFRSF10A PTPRH RGS13

4.75e-0416242344ef0932ee38964ff11edc2aa14698d9db3b2b6b
ToppCellnucseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Suprabasal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DKK1 CCN3 SLPI

4.75e-04162423112fa4de685727f6c8bf6fc4afb82de0524070ad
ToppCellAT1-AT2_cells-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

WNT10A DKK1 NLRP8

4.75e-0416242357d627259d27f39885bf416d74bcb6656db6e27b
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Basal_2|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X

WNT10A ADCY4 CYYR1

4.83e-04163423f21951e63188eb0c04675a8f81a0da495c26c007
ToppCell390C-Fibroblasts-Fibroblast-F|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

PLAT NR6A1 SLPI

4.92e-041644232957065d7f1332c5280d47be7cc342286f84be3e
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LRP2 NCAM2 GFRA3

4.92e-041644233caf4cdaa0164907893fea61e251fd8b5fa926e4
ToppCellfacs-Pancreas-Exocrine-24m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MIB2 DNAJC10 WDR17

4.92e-04164423b895674ed2df87db8fbfb30b7e31620945588491
ToppCell390C-Fibroblasts-Fibroblast-F-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

PLAT NR6A1 SLPI

4.92e-0416442382e57d618c6e59bca4a03d31caf35b6043dfcf52
ToppCellmoderate-Myeloid-Mast_cell|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

PLAT RGS13 GFRA3

5.09e-04166423c3835b424c63bf11a4e2c47635dc3787fc4a637a
ToppCellP07-Epithelial-alveolar_epithelial_cell-type_II_pneumocyte|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LRP2 MYO5C SLPI

5.09e-04166423021b9344de7957762f81b09a647504b8c8289cf1
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

LRP2 DNAH9 NLRP8

5.18e-041674233edb0570e583bb527165bcd8a4c25a042054043b
ToppCellfacs-Lung-18m-Hematologic-lymphocytic-plasma_cell-plasma_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

WNT10A WDR17 SLPI

5.18e-041674238ec7a98b542b134f48df8fbec351693cc5cfe55c
ToppCellfacs-Lung-18m-Hematologic-lymphocytic-plasma_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

WNT10A WDR17 SLPI

5.18e-04167423a9f28c4649ce344ae3ba3a3acb58da9c7efad901
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

PLAT ADCY4 CYYR1

5.18e-04167423d7fe24cdc4b55a9555ce9e20699f5036b88148e9
ToppCellP28-Epithelial-epithelial_progenitor_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LRP2 GFRA3 MYO5C

5.27e-0416842303c95ad3684caec7a6d581006b237cc5fa230685
ToppCelldroplet-Kidney-nan-21m-Lymphocytic-plasma_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WNT10A NANS SLPI

5.27e-04168423bc7d5f0e5d222922eaf1c8e8c87aab189209d6b6
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP2 WNT10A DKK1

5.37e-041694236937c46b119d4ce382fc8c2fa5925ede5ae89c81
ToppCelldroplet-Liver-LIVER_NPC-30m-Lymphocytic-B_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WNT10A RGS13 SLPI

5.37e-04169423c5015ddb838849ea892a2cae5a739b554eb6d793
ToppCellfacs-Lung-24m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l14|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PGM2L1 NR1I3 SLPI

5.37e-04169423813472d429c0b12580b17b440e00a6d8beb7947f
ToppCellP07-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LRP2 MYO5C SLPI

5.37e-0416942353e863de064d44e1d36e21fb3dbba37ae020f6e9
ToppCellP07-Epithelial-epithelial_progenitor_cell|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LRP2 MYO5C SLPI

5.37e-04169423ec23caecbb0d969307e33e9df8499ddcd1420305
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-mesothelial_cell|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LRP2 WNT10A DKK1

5.37e-041694230cece9b2bb1f58e465c20ec8735a4fc3c1021f03
ToppCellP15-Epithelial-alveolar_epithelial_cell-type_II_pneumocyte|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LRP2 MYO5C SLPI

5.46e-041704236c0619cbe2f01a6de18da0a137f92bda0cbdf075
ToppCellP03-Epithelial-alveolar_epithelial_cell-type_II_pneumocyte|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LRP2 MYO5C SLPI

5.46e-041704233fd37e9b377d6485cea1262c31a8507d18a78514
ToppCell368C-Myeloid-Monocyte-CD16+_Monocyte|Monocyte / Donor, Lineage, Cell class and subclass (all cells)

LRP2 FBLN5 MYO5C

5.46e-041704234a19c7e3bb0f9c2601a10debe7000066789b4150
ToppCellTCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-8|TCGA-Liver / Sample_Type by Project: Shred V9

ADCY4 FBLN5 CYYR1

5.55e-04171423c4a919fe3d56ae6df2fcab6686abacc10befc053
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP11B ALG1L2 SLPI

5.65e-041724235401ac7739f95fb8681cfb4747ab6e447a3c2ae8
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP11B ALG1L2 SLPI

5.65e-04172423b3da7f488d191214d7bb74fbac189fe8c29ee6cd
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

WNT10A TNFRSF10B SLPI

5.65e-04172423bd73fd3520064d430a153cfdd5c2858b6c184c59
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

WNT10A TNFRSF10B SLPI

5.65e-0417242347ee78ed3ba6516dad8f12dbf70bca5ed1c60aff
ToppCellfacs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l10|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADCY4 TNFRSF10B NR1I3

5.65e-04172423c84cab89c97d647b8a256fd08e33d9102810febd
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ATP11B ALG1L2 SLPI

5.65e-0417242374dd4a7acb2cf857fed20219e4d7dc1adfbaa398
ToppCellFLU-Healthy-5|Healthy / Virus stimulation, Condition and Cluster

WNT10A FBLN5 NR6A1

5.74e-041734238c218ec1ba927e9312f3df5f312395e907ab64ab
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRH NR1I3 VDR

5.74e-04173423e1378201b15ffb98e196ac39fe3ee4b4078953bd
ToppCellfacs-Large_Intestine-Proximal-3m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTPRH NR1I3 VDR

5.74e-0417342399532bb768ee35fed939a377acb5215d3f8904bd
ToppCellFLU-Healthy-5|FLU / Virus stimulation, Condition and Cluster

WNT10A FBLN5 NR6A1

5.74e-04173423bd4f06d971f9d138749094047c9337dfbaf5da31
ToppCell10x5'-GI_small-bowel-Mast|GI_small-bowel / Manually curated celltypes from each tissue

PLAT RGS13 GFRA3

5.84e-04174423e94c980b25edfd0e8598c416828801fcc00e8ead
Drug2-(3'-methoxyphenyl)-6-pyrrolidinyl-4-quinazolinone

ATM TNFRSF10B TNFRSF10A

8.85e-0711413ctd:C416653
Drugbutylphen

TNFRSF10B TNFRSF10A NR1I3

3.62e-0617413ctd:C006862
DrugPargyline hydrochloride [306-07-0]; Down 200; 20.4uM; HL60; HG-U133A

ATM TNFRSF10B PSME4 DNAJC10 SUCO

2.31e-051914151418_DN
DrugAcetylsalicylsalicylic acid [530-75-6]; Down 200; 13.4uM; MCF7; HT_HG-U133A

RNF216 NCAM2 TNFRSF10B SBF1 VDR

2.49e-051944156778_DN
DrugDanazol [17230-88-5]; Up 200; 11.8uM; PC3; HG-U133A

CHD7 ATM DNAJC10 SBF1 CCN3

2.81e-051994151954_UP
Drugbis(acetato)(1-adamantylamine)amminedichloroplatinum(IV)

TNFRSF10B TNFRSF10A

3.15e-055412ctd:C482801
DrugDuP 697

TNFRSF10B TNFRSF10A

3.15e-055412ctd:C064874
DrugDaunorubicin

PLAT ATM TNFRSF10B TNFRSF10A VDR

4.16e-05216415ctd:D003630
DiseaseVitamin D Deficiency

LRP2 VDR

1.88e-062412C0042870
DiseaseBenign Neoplasm

ATM TNFRSF10A DNAJC10 VDR

2.45e-0668414C0086692
DiseaseNeoplasms

ATM TNFRSF10A DNAJC10 VDR

2.45e-0668414C0027651
DiseaseProstatic Neoplasms

LRP2 FBLN5 CHD7 ATM TNFRSF10A DNAJC10 VDR

2.03e-05616417C0033578
DiseaseMalignant neoplasm of prostate

LRP2 FBLN5 CHD7 ATM TNFRSF10A DNAJC10 VDR

2.03e-05616417C0376358
DiseaseMalignant Neoplasms

ATM TNFRSF10A DNAJC10 VDR

3.02e-05128414C0006826
DiseasePosterior Choroidal Artery Infarction

PLAT VDR

1.03e-0411412C0887799
DiseaseCerebral Infarction, Left Hemisphere

PLAT VDR

1.03e-0411412C0751010
DiseaseAnterior Choroidal Artery Infarction

PLAT VDR

1.03e-0411412C0751012
DiseaseCerebral Infarction, Right Hemisphere

PLAT VDR

1.03e-0411412C0751011
DiseaseSubcortical Infarction

PLAT VDR

1.03e-0411412C0751014
DiseaseCerebral Infarction

PLAT VDR

1.03e-0411412C0007785
DiseaseRespiratory Depression

PLAT FBLN5

1.46e-0413412C0235063
DiseaseRespiratory Insufficiency

PLAT FBLN5

1.46e-0413412C0035229
DiseaseRespiratory Failure

PLAT FBLN5

1.46e-0413412C1145670
Diseasehead and neck squamous cell carcinoma (is_implicated_in)

TNFRSF10B TNFRSF10A

1.96e-0415412DOID:5520 (is_implicated_in)
DiseaseAlopecia, Male Pattern

TNFRSF10A VDR

1.96e-0415412C4083212
DiseaseAndrogenetic Alopecia

TNFRSF10A VDR

1.96e-0415412C0162311
DiseaseFemale pattern alopecia (disorder)

TNFRSF10A VDR

1.96e-0415412C0263477
DiseaseMalignant lymphoma, lymphocytic, intermediate differentiation, diffuse

WNT10A ATM

2.23e-0416412C0334634
DiseasePseudopelade

TNFRSF10A VDR

3.17e-0419412C0086873
DiseaseAlopecia

TNFRSF10A VDR

3.17e-0419412C0002170
Diseaseosteoarthritis (biomarker_via_orthology)

TNFRSF10B TNFRSF10A

3.89e-0421412DOID:8398 (biomarker_via_orthology)
Diseaseesophagus adenocarcinoma (is_implicated_in)

TNFRSF10A VDR

3.89e-0421412DOID:4914 (is_implicated_in)
DiseaseImmunologic Deficiency Syndromes

CHD7 ATM

4.68e-0423412C0021051
DiseaseChild Development Disorders, Specific

LRP2 NANS

7.47e-0429412C0085997
DiseaseChild Development Deviations

LRP2 NANS

7.47e-0429412C0085996
DiseaseAge related macular degeneration

FBLN5 TNFRSF10A

7.99e-0430412C0242383
DiseaseVentricular Dysfunction, Left

PLAT ATM

7.99e-0430412C0242698
DiseaseDevelopmental Disabilities

LRP2 NANS

7.99e-0430412C0008073
Diseasecolon cancer (biomarker_via_orthology)

TNFRSF10B TNFRSF10A

1.35e-0339412DOID:219 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
CQACRLKRCVDIGMM

VDR

76

P11473
MKVVDMFRCCLPACA

ALG1L2

161

C9J202
CVRMGLDMCRAIRKL

ADCY4

341

Q8NFM4
SCFVAMCRRVCRMPV

CHD7

2016

Q9P2D1
QMCRRHCCDIYKLVM

RBM44

616

Q6ZP01
CRLQKCLDAGMRKDM

NR1I3

66

Q14994
AIMNCDKMCVVVRRE

NLRP8

106

Q86W28
VIAGIAICICMCMKN

CYYR1

76

Q96J86
AICICMCMKNHRATR

CYYR1

81

Q96J86
MRCCHICKLPGRVMG

EXTL2

1

Q9UBQ6
NGMNKELRDRLCCRM

PGM2L1

51

Q6PCE3
KCDNGRCIEMMKLCN

LRP2

3081

P98164
VRMMNCCLQDCTSLD

SBF1

626

O95248
LRNMMQLCTRCLSNC

ATM

776

Q13315
VFRRCCEKTMEVMRN

ATM

2926

Q13315
RNRQCEMLKQTRLCM

CCN3

231

P48745
CMCHRRMKNQVACLD

GFRA3

101

O60609
CKRMDLVCQRMLNQG

FBXO28

91

Q9NVF7
VEDQIGACRRRMKCC

DEFB109B

46

Q30KR1
TLMERVQRMMGLCCG

DNAH9

991

Q9NYC9
RKMQGLMFRCSASCC

FAM136A

26

Q96C01
CGDDRMLCRMKGVNS

DNAJC10

186

Q8IXB1
CRTIPEACRGDMMCV

FBLN5

46

Q9UBX5
KRRKRCMRHAMCCPG

DKK1

116

O94907
MSRRNCWICKMCRDE

RGS13

1

O14921
CARRMKKCIRCQVVV

MIB2

856

Q96AX9
RCQYCRLLKCLQMGM

NR6A1

111

Q15406
EMDGQCKRDLKCCMG

SLPI

106

P03973
MACREFEMGRKKCER

PTPN12

131

Q05209
AKRMIRMAKECGADC

NANS

36

Q9NR45
MSCRCGAQMCYLCRV

RNF216

691

Q9NWF9
LARKCMMISVCFPCV

WDR17

1011

Q8IZU2
MEVCRNCSAVLCCRM

ATP11B

781

Q9Y2G3
MDAMKRGLCCVLLLC

PLAT

1

P00750
IRQCGLLMCITRRMC

NCAM2

726

O15394
LVTMENGFRCMACCR

FAM170A

221

A1A519
EMCRKCRTGCPRGMV

TNFRSF10B

151

O14763
CVVLGLMLCMQRCRN

SUCO

1021

Q9UBS9
MVADMCRAAVKCCPE

PSME4

626

Q14997
AEMCRKCSRGCPRGM

TNFRSF10A

201

O00220
RQAVMENMRRKCKCH

WNT10A

251

Q9GZT5
ERAGCRQREMMKLTC

ZFAND2B

101

Q8WV99
VMLTNCMEAGRVKCE

PTPRH

916

Q9HD43
DMCSCRKGMQIRCNI

MYO5C

1596

Q9NQX4