Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	acetylcholine binding	CHRFAM7A CHRNA7	3.48e-04	13	43	2	GO:0042166
GeneOntologyMolecularFunction	chloride channel regulator activity	CHRFAM7A CHRNA7	4.67e-04	15	43	2	GO:0017081
GeneOntologyMolecularFunction	adenylate cyclase binding	CHRFAM7A CHRNA7	5.33e-04	16	43	2	GO:0008179
GeneOntologyMolecularFunction	acetylcholine-gated monoatomic cation-selective channel activity	CHRFAM7A CHRNA7	6.04e-04	17	43	2	GO:0022848
GeneOntologyMolecularFunction	toxic substance binding	CHRFAM7A CHRNA7	6.78e-04	18	43	2	GO:0015643
GeneOntologyMolecularFunction	acetylcholine receptor activity	CHRFAM7A CHRNA7	1.11e-03	23	43	2	GO:0015464
GeneOntologyMolecularFunction	neurotransmitter receptor activity	GPR158 CHRFAM7A CHRNA7	1.30e-03	100	43	3	GO:0030594
GeneOntologyMolecularFunction	amyloid-beta binding	CHRFAM7A CHRNA7 TLR2	1.38e-03	102	43	3	GO:0001540
GeneOntologyMolecularFunction	enzyme regulator activity	CCNL2 PLCB1 ERCC4 ERCC6 CCNYL3 CABIN1 MYCBP2 GPR158 TIAM2	2.79e-03	1418	43	9	GO:0030234
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	CHD7 ERCC6	2.88e-03	37	43	2	GO:0140658
GeneOntologyMolecularFunction	excitatory extracellular ligand-gated monoatomic ion channel activity	CHRFAM7A CHRNA7	3.87e-03	43	43	2	GO:0005231
GeneOntologyBiologicalProcess	positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure	CHRFAM7A CHRNA7	4.05e-06	2	42	2	GO:0001988
GeneOntologyBiologicalProcess	baroreceptor response to decreased systemic arterial blood pressure	CHRFAM7A CHRNA7	1.21e-05	3	42	2	GO:0001982
GeneOntologyBiologicalProcess	generation of ovulation cycle rhythm	CHRFAM7A CHRNA7	2.42e-05	4	42	2	GO:0060112
GeneOntologyBiologicalProcess	protein-DNA complex organization	BDP1 RRP8 ZDBF2 CHD7 TAF2 ERCC6 RESF1 CABIN1 TTF1 ZNF518A	2.42e-05	999	42	10	GO:0071824
GeneOntologyBiologicalProcess	sensory processing	CHRFAM7A CHRNA7	4.03e-05	5	42	2	GO:0050893
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback	CHRFAM7A CHRNA7	6.04e-05	6	42	2	GO:0001978
GeneOntologyBiologicalProcess	regulation of systemic arterial blood pressure by baroreceptor feedback	CHRFAM7A CHRNA7	1.12e-04	8	42	2	GO:0003025
GeneOntologyBiologicalProcess	positive regulation of CoA-transferase activity	CHRFAM7A CHRNA7	1.44e-04	9	42	2	GO:1905920
GeneOntologyBiologicalProcess	acetylcholine receptor signaling pathway	PLCB1 CHRFAM7A CHRNA7	1.53e-04	51	42	3	GO:0095500
GeneOntologyBiologicalProcess	cellular response to acetylcholine	PLCB1 CHRFAM7A CHRNA7	1.71e-04	53	42	3	GO:1905145
GeneOntologyBiologicalProcess	regulation of peptidyl-serine phosphorylation	GGNBP2 ERCC6 CHRFAM7A CHRNA7	1.71e-04	137	42	4	GO:0033135
GeneOntologyBiologicalProcess	cognition	PLCB1 CHD7 GPR158 CHRFAM7A CHRNA7 TLR2	2.02e-04	423	42	6	GO:0050890
GeneOntologyBiologicalProcess	response to acetylcholine	PLCB1 CHRFAM7A CHRNA7	2.02e-04	56	42	3	GO:1905144
GeneOntologyBiologicalProcess	regulation of CoA-transferase activity	CHRFAM7A CHRNA7	2.20e-04	11	42	2	GO:1905918
GeneOntologyBiologicalProcess	behavioral response to nicotine	CHRFAM7A CHRNA7	2.20e-04	11	42	2	GO:0035095
GeneOntologyBiologicalProcess	regulation of synapse structural plasticity	CHRFAM7A CHRNA7	2.64e-04	12	42	2	GO:0051823
GeneOntologyBiologicalProcess	regulation of synaptic transmission, dopaminergic	CHRFAM7A CHRNA7	3.11e-04	13	42	2	GO:0032225
GeneOntologyBiologicalProcess	postsynaptic signal transduction	PLCB1 CHRFAM7A CHRNA7	3.75e-04	69	42	3	GO:0098926
GeneOntologyBiologicalProcess	chromatin organization	RRP8 ZDBF2 CHD7 ERCC6 RESF1 CABIN1 TTF1 ZNF518A	3.89e-04	896	42	8	GO:0006325
GeneOntologyBiologicalProcess	dendrite arborization	CHRFAM7A CHRNA7	4.18e-04	15	42	2	GO:0140059
GeneOntologyBiologicalProcess	behavioral response to ethanol	CHRFAM7A CHRNA7	5.40e-04	17	42	2	GO:0048149
GeneOntologyBiologicalProcess	chromatin remodeling	RRP8 ZDBF2 CHD7 ERCC6 RESF1 CABIN1 TTF1	6.76e-04	741	42	7	GO:0006338
GeneOntologyBiologicalProcess	regulation of amyloid fibril formation	CHRFAM7A CHRNA7	6.77e-04	19	42	2	GO:1905906
GeneOntologyBiologicalProcess	regulation of response to drug	CHRFAM7A CHRNA7	8.29e-04	21	42	2	GO:2001023
GeneOntologyBiologicalProcess	regulation of interleukin-6 production	TUT4 CHRFAM7A CHRNA7 TLR2	8.94e-04	212	42	4	GO:0032675
GeneOntologyBiologicalProcess	learning	PLCB1 CHRFAM7A CHRNA7 TLR2	8.94e-04	212	42	4	GO:0007612
GeneOntologyCellularComponent	spine apparatus membrane	CHRFAM7A CHRNA7	1.24e-05	3	43	2	GO:0098897
GeneOntologyCellularComponent	spine apparatus	CHRFAM7A CHRNA7	1.47e-04	9	43	2	GO:0097444
GeneOntologyCellularComponent	acetylcholine-gated channel complex	CHRFAM7A CHRNA7	6.19e-04	18	43	2	GO:0005892
GeneOntologyCellularComponent	postsynaptic specialization membrane	ACTN2 GPR158 CHRFAM7A CHRNA7	7.63e-04	201	43	4	GO:0099634
GeneOntologyCellularComponent	glycinergic synapse	CHRFAM7A CHRNA7	7.67e-04	20	43	2	GO:0098690
GeneOntologyCellularComponent	axolemma	CHRFAM7A CHRNA7	8.47e-04	21	43	2	GO:0030673
GeneOntologyCellularComponent	cholinergic synapse	CHRFAM7A CHRNA7	9.30e-04	22	43	2	GO:0098981
MousePheno	airway basal cell hyperplasia	CHRFAM7A CHRNA7	4.45e-06	2	30	2	MP:0011115
MousePheno	abnormal airway basal cell differentiation	CHRFAM7A CHRNA7	4.45e-06	2	30	2	MP:0011114
MousePheno	abnormal airway basal cell morphology	CHRFAM7A CHRNA7	4.45e-06	2	30	2	MP:0011113
MousePheno	abnormal nicotine-mediated receptor currents	CHRFAM7A CHRNA7	2.66e-05	4	30	2	MP:0009475
MousePheno	impaired olfaction	CHD7 CHRFAM7A CHRNA7	3.14e-05	29	30	3	MP:0008544
MousePheno	abnormal habenula morphology	CHD7 MYCBP2	4.43e-05	5	30	2	MP:0004082
MousePheno	abnormal parietal lobe morphology	CHD7 CHRFAM7A CHRNA7	6.60e-05	37	30	3	MP:0000794
MousePheno	abnormal brain interneuron morphology	MYCBP2 CHRFAM7A CHRNA7	6.60e-05	37	30	3	MP:0004101
MousePheno	failure of neuromuscular synapse presynaptic differentiation	CHRFAM7A CHRNA7	6.64e-05	6	30	2	MP:0001054
MousePheno	abnormal retrosplenial region morphology	CHD7 WASF1	9.29e-05	7	30	2	MP:0012489
MousePheno	abnormal GABAergic neuron physiology	CHRFAM7A CHRNA7	1.24e-04	8	30	2	MP:0011987
MousePheno	abnormal olfaction	CHD7 CHRFAM7A CHRNA7	1.63e-04	50	30	3	MP:0001984
MousePheno	abnormal cingulate gyrus morphology	CHD7 WASF1	1.98e-04	10	30	2	MP:0004167
MousePheno	abnormal cerebral hemisphere morphology	PLCB1 CHD7 CR1L MYCBP2 WASF1 CHRFAM7A CHRNA7	2.20e-04	599	30	7	MP:0008540
MousePheno	abnormal olfactory system physiology	CHD7 CHRFAM7A CHRNA7	2.54e-04	58	30	3	MP:0001983
MousePheno	abnormal response to stress-induced hyperthermia	CHD7 GPR158	2.90e-04	12	30	2	MP:0010165
MousePheno	impaired spatial working memory	CHRFAM7A CHRNA7	2.90e-04	12	30	2	MP:0014370
MousePheno	decreased erythroblast number	CHRFAM7A CHRNA7	2.90e-04	12	30	2	MP:0011179
MousePheno	abnormal cingulate cortex morphology	CHD7 WASF1	3.42e-04	13	30	2	MP:0020749
MousePheno	abnormal common carotid artery morphology	CHD7 MRTFB	3.42e-04	13	30	2	MP:0012729
MousePheno	abnormal pulmonary trunk morphology	CHD7 ACTN2	3.99e-04	14	30	2	MP:0000486
MousePheno	abnormal hepatocyte morphology	ERCC4 MRPS12 WASF1 TLR2	4.13e-04	166	30	4	MP:0000607
MousePheno	abnormal circulating alanine transaminase level	RRP8 GGNBP2 CHD7 FAM199X ESCO1 TLR2	5.68e-04	498	30	6	MP:0001573
MousePheno	abnormal fourth pharyngeal arch artery morphology	CHD7 MRTFB	5.94e-04	17	30	2	MP:0006354
MousePheno	abnormal cerebral cortex morphology	CHD7 MYCBP2 WASF1 CHRFAM7A CHRNA7	6.07e-04	328	30	5	MP:0000788
MousePheno	abnormal GABA-mediated receptor currents	CHRFAM7A CHRNA7	6.67e-04	18	30	2	MP:0004008
MousePheno	abnormal sixth pharyngeal arch artery morphology	CHD7 MRTFB	6.67e-04	18	30	2	MP:0006355
MousePheno	abnormal sixth pharyngeal arch morphology	CHD7 MRTFB	6.67e-04	18	30	2	MP:0006347
MousePheno	decreased fetal cardiomyocyte proliferation	CHD7 ACTN2	6.67e-04	18	30	2	MP:0011395
MousePheno	abnormal fornicate gyrus morphology	CHD7 WASF1	7.44e-04	19	30	2	MP:0004169
MousePheno	abnormal epithalamus morphology	CHD7 MYCBP2	7.44e-04	19	30	2	MP:0000840
MousePheno	decreased circulating alanine transaminase level	CHD7 ESCO1 TLR2	7.56e-04	84	30	3	MP:0002942
MousePheno	abnormal circulating lipoprotein level	CHD7 TAF2 CHRFAM7A ESCO1 CHRNA7 TLR2	8.12e-04	533	30	6	MP:0010330
MousePheno	abnormal lipoprotein level	CHD7 TAF2 CHRFAM7A ESCO1 CHRNA7 TLR2	8.12e-04	533	30	6	MP:0010329
MousePheno	decreased CNS synapse formation	CHRFAM7A CHRNA7	1.00e-03	22	30	2	MP:0004998
MousePheno	abnormal neuromuscular synapse morphology	MYCBP2 CHRFAM7A CHRNA7	1.08e-03	95	30	3	MP:0001053
MousePheno	abnormal fourth pharyngeal arch morphology	CHD7 MRTFB	1.10e-03	23	30	2	MP:0006340
MousePheno	abnormal limbic system morphology	PLCB1 CHD7 CR1L MYCBP2 WASF1	1.15e-03	378	30	5	MP:0004166
MousePheno	abnormal somatic motor system morphology	MYCBP2 CHRFAM7A CHRNA7	1.18e-03	98	30	3	MP:0001051
MousePheno	abnormal susceptibility to kidney reperfusion injury	CR1L TLR2	1.30e-03	25	30	2	MP:0004040
MousePheno	abnormal GABAergic neuron morphology	CHRFAM7A CHRNA7	1.30e-03	25	30	2	MP:0003245
MousePheno	abnormal telencephalon morphology	PLCB1 CHD7 CR1L MYCBP2 WASF1 CHRFAM7A CHRNA7	1.36e-03	812	30	7	MP:0000787
MousePheno	abnormal liver lobule morphology	ERCC4 MRPS12 WASF1 TLR2	1.38e-03	229	30	4	MP:0008987
MousePheno	increased cellular sensitivity to ultraviolet irradiation	ERCC4 ERCC6	1.40e-03	26	30	2	MP:0008410
MousePheno	abnormal liver parenchyma morphology	ERCC4 MRPS12 WASF1 TLR2	1.71e-03	243	30	4	MP:0008986
MousePheno	abnormal cholesterol level	CHD7 TAF2 MRPS12 CHRFAM7A ESCO1 CHRNA7 TLR2	1.99e-03	867	30	7	MP:0003947
MousePheno	abnormal estrous cycle	CHD7 CHRFAM7A CHRNA7	2.11e-03	120	30	3	MP:0001927
MousePheno	abnormal cerebral cortex pyramidal cell morphology	CHRFAM7A CHRNA7	2.12e-03	32	30	2	MP:0009969
MousePheno	lethality throughout fetal growth and development	GGNBP2 CHD7 ACTN2 MRTFB CR1L	2.14e-03	435	30	5	MP:0006208
MousePheno	abnormal sterol level	CHD7 TAF2 MRPS12 CHRFAM7A ESCO1 CHRNA7 TLR2	2.17e-03	880	30	7	MP:0012224
MousePheno	abnormal somatosensory cortex morphology	CHRFAM7A CHRNA7	2.26e-03	33	30	2	MP:0000859
MousePheno	lethality throughout fetal growth and development, complete penetrance	GGNBP2 ACTN2 MRTFB CR1L	2.28e-03	263	30	4	MP:0011099
MousePheno	taste/olfaction phenotype	CHD7 CHRFAM7A CHRNA7	2.38e-03	125	30	3	MP:0005394
MousePheno	abnormal brain internal capsule morphology	CHD7 MYCBP2	2.39e-03	34	30	2	MP:0008128
MousePheno	abnormal ovulation cycle	CHD7 CHRFAM7A CHRNA7	2.43e-03	126	30	3	MP:0009344
Domain	SANT	BDP1 CHD7 TTF1	1.79e-04	50	41	3	SM00717
Domain	SANT/Myb	BDP1 CHD7 TTF1	2.01e-04	52	41	3	IPR001005
Domain	Acetylcholine_rcpt_TM	CHRFAM7A CHRNA7	1.16e-03	23	41	2	IPR027361
Domain	-	CHRFAM7A CHRNA7	1.16e-03	23	41	2	1.20.120.370
Domain	SNF2_N	CHD7 ERCC6	2.24e-03	32	41	2	PF00176
Domain	SNF2_N	CHD7 ERCC6	2.24e-03	32	41	2	IPR000330
Domain	MYB_LIKE	BDP1 TTF1	3.14e-03	38	41	2	PS50090
Domain	Neurotransmitter_ion_chnl_CS	CHRFAM7A CHRNA7	4.38e-03	45	41	2	IPR018000
Domain	Neur_chan_memb	CHRFAM7A CHRNA7	4.58e-03	46	41	2	PF02932
Domain	Neur_chan_LBD	CHRFAM7A CHRNA7	4.77e-03	47	41	2	PF02931
Domain	Neur_channel	CHRFAM7A CHRNA7	4.77e-03	47	41	2	IPR006201
Domain	Neur_chan_lig-bd	CHRFAM7A CHRNA7	4.77e-03	47	41	2	IPR006202
Domain	NEUROTR_ION_CHANNEL	CHRFAM7A CHRNA7	4.77e-03	47	41	2	PS00236
Domain	Neurotrans-gated_channel_TM	CHRFAM7A CHRNA7	4.77e-03	47	41	2	IPR006029
Domain	-	CHRFAM7A CHRNA7	4.77e-03	47	41	2	2.70.170.10
Pubmed	Therapeutic responses to Roseomonas mucosa in atopic dermatitis may involve lipid-mediated TNF-related epithelial repair.	CHRFAM7A CHRNA7 TLR2	2.88e-07	11	43	3	32908007
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	PLCB1 CHD7 MRTFB MYCBP2 GPR158 ZNF518A	3.42e-07	225	43	6	12168954
Pubmed	Enhancing cognitive function in chronic TBI: The Role of α7 nicotinic acetylcholine receptor modulation.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	38070724
Pubmed	Inflammatory cytokines decrease the expression of nicotinic acetylcholine receptor during the cell maturation.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	19626424
Pubmed	Episodic memory performance predicted by the 2bp deletion in exon 6 of the "alpha 7-like" nicotinic receptor subunit gene.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	17012698
Pubmed	Cholinergic Pathway Suppresses Pulmonary Innate Immunity Facilitating Pneumonia After Stroke.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	26451017
Pubmed	Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer's disease-like pathology.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	34453977
Pubmed	Perinatal hypoxia-ischemia reduces α 7 nicotinic receptor expression and selective α 7 nicotinic receptor stimulation suppresses inflammation and promotes microglial Mox phenotype.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	24757672
Pubmed	Inhibition of pancreatic acinar mitochondrial thiamin pyrophosphate uptake by the cigarette smoke component 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	26999808
Pubmed	Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	27129924
Pubmed	Neuroprotection afforded by nicotine against oxygen and glucose deprivation in hippocampal slices is lost in alpha7 nicotinic receptor knockout mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	17291692
Pubmed	Sensorimotor gating and spatial learning in α7-nicotinic receptor knockout mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	23521765
Pubmed	Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	28258105
Pubmed	The cholinergic anti-inflammatory system limits T cell infiltration into the neurodegenerative CNS, but cannot counteract complex CNS inflammation.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	19344760
Pubmed	Loss of α7nAChR enhances endothelial-to-mesenchymal transition after myocardial infarction via NF-κB activation.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	35926661
Pubmed	The alpha7 nicotinic receptor agonist 4OH-GTS-21 protects axotomized septohippocampal cholinergic neurons in wild type but not amyloid-overexpressing transgenic mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	17640819
Pubmed	Contribution of α7 nicotinic receptor to airway epithelium dysfunction under nicotine exposure.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	23431157
Pubmed	Bidirectional Regulation of Aggression in Mice by Hippocampal Alpha-7 Nicotinic Acetylcholine Receptors.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	29114104
Pubmed	Autophagy is Involved in Neuroprotective Effect of Alpha7 Nicotinic Acetylcholine Receptor on Ischemic Stroke.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	33995108
Pubmed	E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	32552811
Pubmed	Reduced CHRNA7 expression in C3H mice is associated with increases in hippocampal parvalbumin and glutamate decarboxylase-67 (GAD67) as well as altered levels of GABA(A) receptor subunits.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	24836856
Pubmed	Modulation of the MAPKs pathways affects Aβ-induced cognitive deficits in Alzheimer's disease via activation of α7nAChR.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	31904546
Pubmed	Studies of sperm from mutant mice suggesting that two neurotransmitter receptors are important to the zona pellucida-initiated acrosome reaction.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	15948184
Pubmed	Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	35678315
Pubmed	Age-Associated Tooth Loss and Oral Microbial Dysbiosis in a Mouse Genetic Model of Chronic Nicotine Exposure.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	33117372
Pubmed	Functional role of alpha7 nicotinic receptor in physiological control of cutaneous homeostasis.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	12628457
Pubmed	Activation of α-7 nicotinic acetylcholine receptor reduces ischemic stroke injury through reduction of pro-inflammatory macrophages and oxidative stress.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	25157794
Pubmed	Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	19615981
Pubmed	Splenic nerve denervation attenuates depression-like behaviors in Chrna7 knock-out mice via the spleen-gut-brain axis.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	38944290
Pubmed	Nicotine withdrawal-induced inattention is absent in alpha7 nAChR knockout mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	28243714
Pubmed	Mesenchymal Stem Cells or Interleukin-6 Improve Episodic Memory of Mice Lacking α7 Nicotinic Acetylcholine Receptors.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	31202708
Pubmed	Prenatal nicotine exposure alters lung function and airway geometry through α7 nicotinic receptors.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	22246862
Pubmed	Stimulation of the α7 nicotinic acetylcholine receptor protects against sepsis by inhibiting Toll-like receptor via phosphoinositide 3-kinase activation.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	24298024
Pubmed	Lung eosinophilia induced by house dust mites or ovalbumin is modulated by nicotinic receptor α7 and inhibited by cigarette smoke.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	29975102
Pubmed	α7-nAChR Knockout Mice Decreases Biliary Hyperplasia and Liver Fibrosis in Cholestatic Bile Duct-Ligated Mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	29580318
Pubmed	Alpha-7 Nicotinic Receptor Dampens Murine Osteoblastic Response to Inflammation and Age-Related Osteoarthritis.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	35479080
Pubmed	[Activation of α7 nAChR improves white fat homeostasis and promotes beige adipogenesis and thermogenesis in obese mice].	CHRFAM7A CHRNA7	1.49e-06	2	43	2	38597441
Pubmed	Activation of Nicotinic Acetylcholine Receptors Decreases Apoptosis in Human and Female Murine Pancreatic Islets.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	27471776
Pubmed	Targeting α-7 nicotinic acetylcholine receptor in the enteric nervous system: a cholinergic agonist prevents gut barrier failure after severe burn injury.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	22688057
Pubmed	α7 Nicotinic acetylcholine receptor agonist attenuates neuropathological changes associated with intracerebral hemorrhage in mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	22820264
Pubmed	Stimulation of α7-nAChRs coordinates autophagy and apoptosis signaling in experimental knee osteoarthritis.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	33953172
Pubmed	Different Effects of Nicotine and N-Stearoyl-ethanolamine on Episodic Memory and Brain Mitochondria of α7 Nicotinic Acetylcholine Receptor Knockout Mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	32028688
Pubmed	Genetic variation in CHRNA7 and CHRFAM7A is associated with nicotine dependence and response to varenicline treatment.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	30089821
Pubmed	Nicotinic acetylcholine receptor activation reduces skeletal muscle inflammation of mdx mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	20615555
Pubmed	Nicotine physical dependence in the mouse: involvement of the alpha7 nicotinic receptor subtype.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	15896732
Pubmed	Activation of α7 Nicotinic Acetylcholine Receptor Ameliorates Zymosan-Induced Acute Kidney Injury in BALB/c Mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	30429582
Pubmed	A transgenic mouse model reveals fast nicotinic transmission in hippocampal pyramidal neurons.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	21501254
Pubmed	α7-cholinergic receptor mediates vagal induction of splenic norepinephrine.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	21339364
Pubmed	Cardiopulmonary arrest and resuscitation disrupts cholinergic anti-inflammatory processes: a role for cholinergic α7 nicotinic receptors.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	21368056
Pubmed	Genetic variation within the Chrna7 gene modulates nicotine reward-like phenotypes in mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	24289814
Pubmed	Requisite role of the cholinergic alpha7 nicotinic acetylcholine receptor pathway in suppressing Gram-negative sepsis-induced acute lung inflammatory injury.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	19949071
Pubmed	Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	1400473
Pubmed	Reversible inhibition of GABAA receptors by alpha7-containing nicotinic receptors on the vertebrate postsynaptic neurons.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	17204496
Pubmed	Activation of Alpha 7 Cholinergic Nicotinic Receptors Reduce Blood-Brain Barrier Permeability following Experimental Traumatic Brain Injury.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	26937017
Pubmed	α7 nicotinic receptors play a role in regulation of cardiac hemodynamics.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	37017608
Pubmed	Impaired hippocampal theta oscillations in the mice null alpha7 nicotinic acetylcholine receptors.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	23795917
Pubmed	Diminished α7 nicotinic acetylcholine receptor (α7nAChR) rescues amyloid-β induced atrial remodeling by oxi-CaMKII/MAPK/AP-1 axis-mediated mitochondrial oxidative stress.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	36603528
Pubmed	Endogenous signaling through alpha7-containing nicotinic receptors promotes maturation and integration of adult-born neurons in the hippocampus.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	20592195
Pubmed	Activation of α7nAChR Promotes Diabetic Wound Healing by Suppressing AGE-Induced TNF-α Production.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	26650489
Pubmed	Increased sensitivity to nicotine-induced seizures in mice expressing the L250T alpha 7 nicotinic acetylcholine receptor mutation.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	11854451
Pubmed	Lack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic acid in adult hippocampal interneurons.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	22848433
Pubmed	Nicotine prevents synaptic impairment induced by amyloid-β oligomers through α7-nicotinic acetylcholine receptor activation.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	23842742
Pubmed	Abeta(1-42) modulation of Akt phosphorylation via alpha7 nAChR and NMDA receptors.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	17292512
Pubmed	Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	16650968
Pubmed	Microglial cell response in α7 nicotinic acetylcholine receptor-deficient mice after systemic infection with Escherichia coli.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	35413868
Pubmed	Circulating brain microvascular endothelial cells (cBMECs) as potential biomarkers of the blood-brain barrier disorders caused by microbial and non-microbial factors.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	23637989
Pubmed	Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7).	CHRFAM7A CHRNA7	1.49e-06	2	43	2	9782083
Pubmed	Long-term improvements in sensory inhibition with gestational choline supplementation linked to α7 nicotinic receptors through studies in Chrna7 null mutation mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	24462939
Pubmed	Probing the putative α7 nAChR/NMDAR complex in human and murine cortex and hippocampus: Different degrees of complex formation in healthy and Alzheimer brain tissue.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	29261717
Pubmed	Altered hippocampal circuit function in C3H alpha7 null mutant heterozygous mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	18199426
Pubmed	Stroke-induced activation of the α7 nicotinic receptor increases Pseudomonas aeruginosa lung injury.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	22490926
Pubmed	Kynurenic acid blunts A1 astrocyte activation against neurodegeneration in HIV-associated neurocognitive disorders.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	36997969
Pubmed	A phenotype for the alpha 7 nicotinic acetylcholine receptor null mutant.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	15364017
Pubmed	Choline, an alpha7 nicotinic acetylcholine receptor agonist, alleviates hyperalgesia in a rat osteoarthritis model.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	23769729
Pubmed	Mice deficient in CHRNA7, a subunit of the nicotinic acetylcholine receptor, produce sperm with impaired motility.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	15944242
Pubmed	Dendritic spine alterations in the hippocampus and parietal cortex of alpha7 nicotinic acetylcholine receptor knockout mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	23270857
Pubmed	Neuronal nicotinic alpha7 receptors modulate inflammatory cytokine production in the skin following ultraviolet radiation.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	18077004
Pubmed	Smoking in adult attention-deficit/hyperactivity disorder: interaction between 15q13 nicotinic genes and Temperament Character Inventory scores.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	19462340
Pubmed	Performance deficit of alpha7 nicotinic receptor knockout mice in a delayed matching-to-place task suggests a mild impairment of working/episodic-like memory.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	16923147
Pubmed	NMR structural analysis of alpha-bungarotoxin and its complex with the principal alpha-neurotoxin-binding sequence on the alpha 7 subunit of a neuronal nicotinic acetylcholine receptor.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	11790782
Pubmed	A role of the subdiaphragmatic vagus nerve in depression-like phenotypes in mice after fecal microbiota transplantation from Chrna7 knock-out mice with depression-like phenotypes.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	33422641
Pubmed	Nicotinic ACh receptor α7 inhibits PDGF-induced migration of vascular smooth muscle cells by activating mitochondrial deacetylase sirtuin 3.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	30270436
Pubmed	Activation of α-7 Nicotinic Acetylcholine Receptor Attenuates Cardiac Inflammation Through NLRP3/Caspase-1/IL-18 Pathway.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	34988776
Pubmed	Genetic deletion of α7 nAChRs reduces hippocampal granule and pyramidal cell number in both sexes but impairs pattern separation in males only.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	37746145
Pubmed	A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	19631623
Pubmed	Deletion of the alpha7 nicotinic receptor subunit gene results in increased sensitivity to several behavioral effects produced by alcohol.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	15770102
Pubmed	Cortical synaptic NMDA receptor deficits in α7 nicotinic acetylcholine receptor gene deletion models: implications for neuropsychiatric diseases.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	24326163
Pubmed	Loss of α7 nicotinic acetylcholine receptors in GABAergic neurons causes sex-dependent decreases in radial glia-like cell quantity and impairments in cognitive and social behavior.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	33398432
Pubmed	Functional role of alpha7 nicotinic receptor in chronic neuropathic and inflammatory pain: studies in transgenic mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	23811428
Pubmed	beta-Amyloid activates presynaptic alpha7 nicotinic acetylcholine receptors reconstituted into a model nerve cell system: involvement of lipid rafts.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	20374280
Pubmed	Proteome profile of the cerebellum from α7 nicotinic acetylcholine receptor deficient mice.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	38185761
Pubmed	Alpha 7 subunit of nAChR regulates migration of human mesenchymal stem cells.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	20720594
Pubmed	α7 nicotinic acetylcholine receptor-mediated neuroprotection against dopaminergic neuron loss in an MPTP mouse model via inhibition of astrocyte activation.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	22624500
Pubmed	Involvement of acetylcholine-α7nAChR in the protective effects of arterial baroreflex against ischemic stroke.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	23106973
Pubmed	Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	33902624
Pubmed	Impaired performance of alpha7 nicotinic receptor knockout mice in the five-choice serial reaction time task.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	17019565
Pubmed	Dilinoleoylphosphatidylcholine ameliorates scopolamine-induced impairment of spatial learning and memory by targeting alpha7 nicotinic ACh receptors.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	19100751
Pubmed	Identification of an alternatively processed nicotinic receptor alpha7 subunit RNA in mouse brain.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	14499477
Pubmed	Multiple calcium channels and kinases mediate alpha7 nicotinic receptor neuroprotection in PC12 cells.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	15969741
Pubmed	Activation of the α7 Nicotinic Acetylcholine Receptor Prevents against Microglial-Induced Inflammation and Insulin Resistance in Hypothalamic Neuronal Cells.	CHRFAM7A CHRNA7	1.49e-06	2	43	2	35883638
Cytoband	16p13.12	ERCC4 MRTFB	3.84e-05	10	43	2	16p13.12
GeneFamily	WD repeat domain containing\|ERCC excision repair associated	ERCC4 ERCC6	3.84e-05	7	25	2	1268
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	BDP1 CHD7 TTF1	5.23e-05	53	25	3	532
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF469 ZNF90 ZNF92 ZNF518A	1.61e-02	718	25	4	28
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ZDBF2 TUT4 RESF1 MYCBP2 TIAM2	8.37e-07	185	42	5	e913c64f9b4873443d88dce270f0b7b6d1b4cbce
ToppCell	droplet-Spleen-nan-18m-Lymphocytic\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBA52 TUT4 MYCBP2 ESCO1	2.63e-05	183	42	4	28cbf909424f3be4491d49832f0aca0386560814
ToppCell	droplet-Spleen-nan-18m-Lymphocytic-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBA52 TUT4 MYCBP2 ESCO1	2.63e-05	183	42	4	3fa608aa6b119869ec3280dc388dfee57160e63a
ToppCell	droplet-Spleen-nan-3m\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBA52 TUT4 ACTN2 ESCO1	2.80e-05	186	42	4	26f1e9930adf2fe4af0819e56f69915bd8330e4a
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TUT4 RESF1 MYCBP2 TIAM2	2.80e-05	186	42	4	1a1e5d85a5ad90afee234c12a9b54a5e93a8a2f2
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-B_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TUT4 RESF1 MYCBP2 TIAM2	2.80e-05	186	42	4	f1366638edaecad5cad6367440f4c693513bed7e
ToppCell	severe-B_cell\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ZDBF2 CHD7 ZNF92 TIAM2	3.30e-05	194	42	4	2fee6083fb56b16d1f04fd0b92ec622fd26ba3fa
ToppCell	mild-MAIT\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PLCB1 BDP1 ZDBF2 RESF1	3.64e-05	199	42	4	cbe1fb6d2c5fca7a1baf1ad20afcdf8e8e11bd84
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CHD7 TUT4 MRTFB RESF1	3.72e-05	200	42	4	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	PLCB1 BDP1 MRTFB MYCBP2	3.72e-05	200	42	4	48d801219bc771d6c7e151dc88ca4c179988de85
Disease	polyneuropathy due to drug (is_implicated_in)	ERCC4 ERCC6	1.70e-06	2	39	2	DOID:14184 (is_implicated_in)
Disease	Cockayne Syndrome, Type I	ERCC4 ERCC6	5.10e-06	3	39	2	C0751039
Disease	cognitive disorder (implicated_via_orthology)	CHRFAM7A CHRNA7	2.54e-05	6	39	2	DOID:1561 (implicated_via_orthology)
Disease	rheumatoid arthritis (biomarker_via_orthology)	CHRFAM7A CHRNA7	2.54e-05	6	39	2	DOID:7148 (biomarker_via_orthology)
Disease	brain disease (implicated_via_orthology)	MYCBP2 TIAM2	2.54e-05	6	39	2	DOID:936 (implicated_via_orthology)
Disease	Cockayne syndrome (implicated_via_orthology)	ERCC4 ERCC6	2.54e-05	6	39	2	DOID:2962 (implicated_via_orthology)
Disease	verbal-numerical reasoning measurement	GGNBP2 ERCC4 ARMH3 GPR158	2.71e-05	131	39	4	EFO_0008394
Disease	egg allergy measurement	ERCC4 COG7	6.09e-05	9	39	2	EFO_0007018
Disease	MYELODYSPLASTIC SYNDROME	PLCB1 ERCC4 TLR2	9.64e-05	67	39	3	C3463824
Disease	schizophrenia (implicated_via_orthology)	PLCB1 CHRFAM7A CHRNA7	1.01e-04	68	39	3	DOID:5419 (implicated_via_orthology)
Disease	nicotine dependence (implicated_via_orthology)	CHRFAM7A CHRNA7	1.11e-04	12	39	2	DOID:0050742 (implicated_via_orthology)
Disease	Neoplasm of uncertain or unknown behavior of ovary	ERCC4 ERCC6	6.76e-04	29	39	2	C0496920
Disease	Hematopoetic Myelodysplasia	PLCB1 TLR2	6.76e-04	29	39	2	C2713368
Disease	Ovarian Carcinoma	ERCC4 ERCC6	7.23e-04	30	39	2	C0029925

Protein segments in the cluster

Peptide	Gene	Start	Entry
RPRQKKTQACLASKH	TTF1	436	Q15361
SKGEKHKNKCQAIRP	BDP1	491	A6H8Y1
QCRLDKNDHIPPAKK	BDP1	2371	A6H8Y1
QSIRKKCKLDHIPPN	COG7	441	P83436
YRRKHKPPKVQEKCQ	ACTN2	326	P35609
PMRHRKKAADKNLPC	ARMH3	426	Q5T2E6
KRHRCQPENSGKKAV	CCDC180	1321	Q9P1Z9
QKPKQKRHRCRNPNK	CHD7	2621	Q9P2D1
RPKQKPKNSKHCRDA	ERCC6	1201	Q03468
KRPGEDKVRPACQHK	CHRNA7	346	P36544
KRSPKPRRKHQVNGC	KIAA1549	1596	Q9HCM3
DAIPKSKKNKRCQLH	GGNBP2	151	Q9H3C7
NNPHLQKKRCSKKGL	GPR158	736	Q5T848
KRKREQPDPSTKKQH	LAYN	261	Q6UX15
SSPCLLPKKKNKHRN	FAM199X	161	Q6PEV8
KNPNDKHRSKKCKDP	MRTFB	271	Q9ULH7
RKKKCGHTNNLRPKK	UBA52	111	P62987
KRPGEDKVRPACQHK	CHRFAM7A	256	Q494W8
KLPGKSFKHDPKRNC	CCNYL3	61	P0C7X3
RHIKHKDCNPAKPEK	CEP104	826	O60308
KCKKPHQQATPDDRS	CABIN1	1361	Q9Y6J0
SRKSKDCKYPQKPHK	CCNL2	446	Q96S94
SAKDKCKRKSCRNPP	CR1L	86	Q2VPA4
PKGKKRKVEHQTACA	ESCO1	201	Q5FWF5
KHITPAPKSKINCRK	MUCL3	156	Q3MIW9
QLAKHLKKCNSREKP	TRMT13	71	Q9NUP7
SKCDKLNPLQNHKRK	RESF1	1281	Q9HCM1
PCHSKSRRNKKKKIP	TAF2	591	Q6P1X5
PKISRKCANRHTRPK	MYCBP2	2986	O75592
KCANRHTRPKKEKSS	MYCBP2	2991	O75592
FTRKPKKPNSANRKC	MRPS12	66	O15235
NRNKIRHTGKKPFKC	ZNF92	161	Q03936
NCKLKKKLPSNSRPA	TIAM2	1366	Q8IVF5
DQPQETVKKRHPCKK	ZDBF2	1761	Q9HCK1
CHKNFKKKRNPRKVR	RSL24D1	36	Q9UHA3
KRKRKCQKHAPINSA	RRP8	131	O43159
QEPPRRKATLHRKCK	ZNF518A	1286	Q6AHZ1
DARCGRHAKAPKDPK	PLCB1	71	Q9NQ66
LAQKCQPPRKKSHRV	ZNF469	2491	Q96JG9
NRHKIRDTGKKPFKC	ZNF90	161	Q03938
KRKQKQKNLDRPHEP	WASF1	176	Q92558
RIRKSHKRPKDPQNK	ERCC4	461	Q92889
KRHATKPCPNNVEKS	TINAG	331	Q9UJW2
RDQSHCKAKKFPNSP	TUT4	91	Q5TAX3
QAKRKPRKAPSRNIC	TLR2	626	O60603