Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionmethylated histone binding

ATRX L3MBTL2 MBTD1

7.11e-0586193GO:0035064
GeneOntologyMolecularFunctionmethylation-dependent protein binding

ATRX L3MBTL2 MBTD1

7.62e-0588193GO:0140034
GeneOntologyMolecularFunctionmodification-dependent protein binding

ATRX L3MBTL2 MBTD1

9.28e-04206193GO:0140030
GeneOntologyMolecularFunctionhistone binding

ATRX L3MBTL2 MBTD1

1.91e-03265193GO:0042393
GeneOntologyMolecularFunctiontransition metal ion binding

L3MBTL2 MBTD1 TMLHE ZMYM5 DTX2

4.28e-031189195GO:0046914
DomainZnf_FCS

L3MBTL2 MBTD1

9.79e-065192IPR012313
DomainZF_FCS

L3MBTL2 MBTD1

1.47e-056192PS51024
DomainMBT

L3MBTL2 MBTD1

3.51e-059192PS51079
DomainMBT

L3MBTL2 MBTD1

3.51e-059192SM00561
DomainMBT

L3MBTL2 MBTD1

4.39e-0510192PF02820
DomainMbt

L3MBTL2 MBTD1

4.39e-0510192IPR004092
DomainRING

RNF114 ATRX DTX2

3.44e-03305193SM00184
DomainZnf_RING

RNF114 ATRX DTX2

4.15e-03326193IPR001841
Domain-

RNF114 ATRX DTX2

1.00e-024491933.30.40.10
DomainZnf_RING/FYVE/PHD

RNF114 ATRX DTX2

1.07e-02459193IPR013083
DomainZnf_C3HC4_RING-type

RNF114 DTX2

1.30e-02172192IPR018957
Domainzf-C3HC4

RNF114 DTX2

2.12e-02223192PF00097
PathwayREACTOME_SCAVENGING_BY_CLASS_A_RECEPTORS

COL3A1 APOB

1.55e-0419142M27221
Pubmed

Genome-wide association study of age at menarche in African-American women.

DSCAML1 UNC13C

1.86e-051219223599027
Pubmed

Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension.

ELP1 APOB

3.38e-051619217137217
Pubmed

Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.

COL3A1 PLAUR APOB

1.37e-0418619320452482
Pubmed

A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).

COL3A1 PLAUR APOB

1.37e-0418619320673868
Pubmed

Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP.

ATRX ZMYM5

1.96e-043819228680062
Pubmed

Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes.

L3MBTL2 MBTD1

2.40e-044219235705031
Pubmed

Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis.

L3MBTL2 MBTD1

2.40e-044219229028833
Pubmed

ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing.

COL3A1 APOB

4.43e-045719223788249
CytobandEnsembl 112 genes in cytogenetic band chr19q13

ZBTB45 PLAUR MARK4

1.24e-021192193chr19q13
GeneFamilySterile alpha motif domain containing|MBT domain containing

L3MBTL2 MBTD1

2.00e-0591421263
GeneFamilyRing finger proteins

RNF114 DTX2

1.86e-0227514258
CoexpressionGSE4590_SMALL_VS_VPREB_POS_LARGE_PRE_BCELL_UP

ELP1 MBTD1 SPATA6

1.97e-04168183M6874
CoexpressionCEBALLOS_TARGETS_OF_TP53_AND_MYC_DN

ATRX PLAUR

2.32e-0433182M1252
CoexpressionGSE2770_IL12_ACT_VS_ACT_CD4_TCELL_2H_UP

TMLHE PLAUR SPATS2

2.96e-04193183M6130
CoexpressionGSE19888_ADENOSINE_A3R_INH_PRETREAT_AND_ACT_BY_A3R_VS_A3R_INH_AND_TCELL_MEMBRANES_ACT_MAST_CELL_UP

ATRX MBTD1 PLAUR

3.00e-04194183M7313
CoexpressionGSE1791_CTRL_VS_NEUROMEDINU_IN_T_CELL_LINE_0.8H_DN

COL3A1 SPATS2 SPATA6

3.00e-04194183M6163
CoexpressionWEINMANN_ADAPTATION_TO_HYPOXIA_DN

COL3A1 PLAUR

3.09e-0438182M7137
CoexpressionGSE1791_CTRL_VS_NEUROMEDINU_IN_T_CELL_LINE_6H_UP

PLAUR SPATS2 SPATA6

3.19e-04198183M6166
CoexpressionGSE17721_CTRL_VS_PAM3CSK4_4H_BMDC_DN

CD72 DSCAML1 DTX2

3.23e-04199183M3738
CoexpressionGSE11961_GERMINAL_CENTER_BCELL_DAY7_VS_PLASMA_CELL_DAY7_UP

DSCAML1 DTX2 SPATS2

3.28e-04200183M9360
CoexpressionGSE9037_CTRL_VS_LPS_4H_STIM_BMDM_UP

ATRX DSCAML1 TMLHE

3.28e-04200183M5803
CoexpressionGSE2585_CTEC_VS_MTEC_THYMUS_DN

CD72 UNC13C DTX2

3.28e-04200183M6274
CoexpressionGSE2585_CTEC_VS_THYMIC_MACROPHAGE_UP

RNF114 CD72 DTX2

3.28e-04200183M6268
CoexpressionGSE5589_LPS_VS_LPS_AND_IL10_STIM_IL6_KO_MACROPHAGE_45MIN_DN

RNF114 CD72 PLAUR

3.28e-04200183M6619
CoexpressionGSE2770_UNTREATED_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_DN

ATRX ZBTB45 SPATA6

3.28e-04200183M6056
CoexpressionZHOU_INFLAMMATORY_RESPONSE_FIMA_UP

COL3A1 TMLHE PLAUR DTX2

3.67e-04517184M7140
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#5_top-relative-expression-ranked_100

ATRX TMLHE

4.15e-0511192gudmap_developingGonad_e14.5_ epididymis_100_k5
CoexpressionAtlasDevelopingGonad_P2_epididymis_emap-30199_k-means-cluster#4_top-relative-expression-ranked_200

ATRX TMLHE

1.15e-0418192gudmap_developingGonad_P2_epididymis_200_k4
CoexpressionAtlasDevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#2_top-relative-expression-ranked_200

ATRX TMLHE

1.58e-0421192gudmap_developingGonad_e14.5_ epididymis_200_k2
CoexpressionAtlasDevelopingGonad_e16.5_epididymis_emap-29702_k-means-cluster#3_top-relative-expression-ranked_100

ATRX TMLHE

1.73e-0422192gudmap_developingGonad_e16.5_epididymis_100_k3
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_k-means-cluster#2_top-relative-expression-ranked_200

ATRX TMLHE

1.90e-0423192gudmap_developingGonad_e18.5_epididymis_200_k2
CoexpressionAtlasDevelopingGonad_e18.5_ovary_emap-12283_k-means-cluster#3_top-relative-expression-ranked_200

ATRX TMLHE

2.43e-0426192gudmap_developingGonad_e18.5_ovary_200_k3
CoexpressionAtlasDevelopingGonad_e12.5_ovary_emap-28876_k-means-cluster#1_top-relative-expression-ranked_100

ATRX TMLHE

2.43e-0426192gudmap_developingGonad_e12.5_ovary_k1_100
CoexpressionAtlasDevelopingGonad_P2_ovary_emap-30224_top-relative-expression-ranked_1000

RNF114 ATRX UNC13C TMLHE DTX2

4.71e-04770195gudmap_developingGonad_P2_ovary_1000
Diseasecardiovascular system disease (is_marker_for)

PLAUR APOB

1.58e-0510182DOID:1287 (is_marker_for)
Diseaseimmature granulocyte count

PLAUR MARK4

4.75e-0517182EFO_0803542
Diseaselevel of Sterol ester (27:1/18:2) in blood serum

APOB MARK4

1.13e-0426182OBA_2045194
DiseaseHypercholesterolemia

COL3A1 APOB

2.57e-0439182C0020443
Diseaseobsolete_red blood cell distribution width

L3MBTL2 TMLHE PLAUR APOB MARK4

1.02e-031347185EFO_0005192
DiseaseFatty Liver

COL3A1 APOB

1.30e-0388182C0015695
DiseaseSteatohepatitis

COL3A1 APOB

1.30e-0388182C2711227
Diseaseobesity (is_marker_for)

PLAUR APOB

1.71e-03101182DOID:9970 (is_marker_for)
DiseaseHypermetropia

DSCAML1 MARK4

1.78e-03103182HP_0000540
Diseaselipoprotein A measurement

DSCAML1 APOB

2.10e-03112182EFO_0006925
Diseaseplatelet crit

ATRX PLAUR APOB MARK4

2.29e-03952184EFO_0007985
Diseaselow density lipoprotein cholesterol measurement, phospholipid measurement

PLAUR APOB

2.40e-03120182EFO_0004611, EFO_0004639
Diseasetriglycerides:total lipids ratio, intermediate density lipoprotein measurement

PLAUR APOB

2.69e-03127182EFO_0008595, EFO_0020947
Diseasetype 2 diabetes mellitus (is_marker_for)

PLAUR APOB

3.07e-03136182DOID:9352 (is_marker_for)
Diseasefree cholesterol measurement, low density lipoprotein cholesterol measurement

PLAUR APOB

3.12e-03137182EFO_0004611, EFO_0008591
Diseasetriglycerides:total lipids ratio, low density lipoprotein cholesterol measurement

PLAUR APOB

3.72e-03150182EFO_0004611, EFO_0020947
Diseasemyocardial infarction (biomarker_via_orthology)

COL3A1 PLAUR

4.22e-03160182DOID:5844 (biomarker_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
TRTYAQSSKCNKVHK

CD72

316

P21854
HSQKQSSSTYSKRCR

KIAA0895

121

Q8NCT3
VSCSRSYSSNSKKAS

MBTD1

76

Q05BQ5
SVSCSRSYSSNSKKA

L3MBTL2

111

Q969R5
YTTHTQTNKTSSFCR

DTX2

156

Q86UW9
KYSHSNSRISARSSK

ELP1

1181

O95163
SSQSCQYTLDAKRKH

APOB

241

P04114
HTSRFSPKKTSSNCN

ATRX

311

P46100
RKNVKSAHSTRNRYS

DSCAML1

1731

Q8TD84
SKGQRSSSSTYHRQR

MARK4

406

Q96L34
SSRASQNITYHCKNS

COL3A1

1361

P02461
CGHSRTSSYASQQSK

FAM102B

201

Q5T8I3
QKTVKNRSCVYSSSA

SPATA31A6

1186

Q5VVP1
VSHPKNSYSTRSRCS

SPATS2

371

Q86XZ4
SCTHSEKTNRTLSYR

PLAUR

66

Q03405
SHCRKTFSSRKNYTK

ZBTB45

406

Q96K62
SHSARSKNKTANSSR

UNC13C

486

Q8NB66
SKIRSHVATCSKYQN

RNF114

101

Q9Y508
TCLSSFSHKRTQNTR

ZMYM5

271

Q9UJ78
RSASCYNSKTHQRSL

TMLHE

81

Q9NVH6
RNLYKKACSSASHTQ

SPATA6

471

Q9NWH7