Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainEF-hand_Ca_insen

ACTN2 ACTN3

1.00e-046492IPR014837
DomainEFhand_Ca_insen

ACTN2 ACTN3

1.00e-046492PF08726
DomainKinase-like_dom

AKT3 PDCD6IP BUB1B PRKDC MAPK4 ACVRL1 MAP3K12

4.98e-04542497IPR011009
DomainFN3

CSF3R UMODL1 CNTN5 MDGA1

1.39e-03185494SM00060
DomainActinin_actin-bd_CS

ACTN2 ACTN3

1.65e-0323492IPR001589
DomainSpectrin

ACTN2 ACTN3

1.65e-0323492PF00435
DomainACTININ_2

ACTN2 ACTN3

1.65e-0323492PS00020
DomainACTININ_1

ACTN2 ACTN3

1.65e-0323492PS00019
Domain-

PREB PLXNA3 STRN3 WDR6 EIF2A

1.75e-033334952.130.10.10
DomainWD40/YVTN_repeat-like_dom

PREB PLXNA3 STRN3 WDR6 EIF2A

1.80e-03335495IPR015943
DomainFN3

CSF3R UMODL1 CNTN5 MDGA1

1.82e-03199494PS50853
DomainFN3_dom

CSF3R UMODL1 CNTN5 MDGA1

2.18e-03209494IPR003961
DomainSer/Thr_kinase_AS

AKT3 BUB1B MAPK4 ACVRL1 MAP3K12

2.37e-03357495IPR008271
DomainPROTEIN_KINASE_ST

AKT3 BUB1B MAPK4 ACVRL1 MAP3K12

2.52e-03362495PS00108
DomainSpectrin_repeat

ACTN2 ACTN3

2.62e-0329492IPR002017
DomainSpectrin/alpha-actinin

ACTN2 ACTN3

3.18e-0332492IPR018159
DomainSPEC

ACTN2 ACTN3

3.18e-0332492SM00150
DomainSulfotransferase_dom

NDST3 CHST7

4.01e-0336492IPR000863
DomainSulfotransfer_1

NDST3 CHST7

4.01e-0336492PF00685
Domain-

CAPN14 ACTN2 ACTN3 PLCE1

4.82e-032614941.10.238.10
DomainBTB-kelch_protein

GAN KLHL32

5.69e-0343492IPR017096
DomainWD_REPEATS_1

PREB STRN3 WDR6 EIF2A

6.02e-03278494PS00678
DomainWD_REPEATS_2

PREB STRN3 WDR6 EIF2A

6.09e-03279494PS50082
DomainWD_REPEATS_REGION

PREB STRN3 WDR6 EIF2A

6.09e-03279494PS50294
DomainEF-hand-dom_pair

CAPN14 ACTN2 ACTN3 PLCE1

6.72e-03287494IPR011992
DomainPROTEIN_KINASE_ATP

AKT3 BUB1B MAPK4 ACVRL1 MAP3K12

6.88e-03459495PS00107
Domain-

GAN KLHL32

7.04e-03484922.120.10.80
Domain-

PLXNA3 CSF3R LRRC24 UMODL1 CNTN5 MDGA1

7.47e-036634962.60.40.10
DomainWD40_repeat_dom

PREB STRN3 WDR6 EIF2A

7.57e-03297494IPR017986
DomainQuinoprotein_ADH-like_supfam

PREB WDR6

8.53e-0353492IPR011047
Domainfn3

CSF3R UMODL1 CNTN5

8.81e-03162493PF00041
DomainProt_kinase_dom

AKT3 BUB1B MAPK4 ACVRL1 MAP3K12

8.91e-03489495IPR000719
DomainC2_dom

PREB SEC63 PLCE1

9.11e-03164493IPR000008
DomainKelch-typ_b-propeller

GAN KLHL32

9.16e-0355492IPR015915
DomainPROTEIN_KINASE_DOM

AKT3 BUB1B MAPK4 ACVRL1 MAP3K12

9.21e-03493495PS50011
DomainIg-like_fold

PLXNA3 CSF3R LRRC24 UMODL1 CNTN5 MDGA1

1.00e-02706496IPR013783
DomainKelch

GAN KLHL32

1.02e-0258492SM00612
Pubmed

Down-regulation of histone H2B by DNA-dependent protein kinase in response to DNA damage through modulation of octamer transcription factor 1.

POU2F1 PRKDC

2.19e-06252214612514
Pubmed

Human skeletal muscle-specific alpha-actinin-2 and -3 isoforms form homodimers and heterodimers in vitro and in vivo.

ACTN2 ACTN3

2.19e-0625229675099
Pubmed

Strength, power, fiber types, and mRNA expression in trained men and women with different ACTN3 R577X genotypes.

ACTN2 ACTN3

2.19e-06252219150855
Pubmed

α-Actinin-2 deficiency results in sarcomeric defects in zebrafish that cannot be rescued by α-actinin-3 revealing functional differences between sarcomeric isoforms.

ACTN2 ACTN3

2.19e-06252222253474
Pubmed

alpha-actinin-3 and performance.

ACTN2 ACTN3

2.19e-06252219696509
Pubmed

Differential regulation of Actn2 and Actn3 expression during unfolded protein response in C2C12 myotubes.

ACTN2 ACTN3

2.19e-06252232451822
Pubmed

Cloning and characterization of two human skeletal muscle alpha-actinin genes located on chromosomes 1 and 11.

ACTN2 ACTN3

2.19e-0625221339456
Pubmed

Condyle modeling stability, craniofacial asymmetry and ACTN3 genotypes: Contribution to TMD prevalence in a cohort of dentofacial deformities.

ENPP1 ACTN3

2.19e-06252232726330
Pubmed

The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells.

ACTN2 ACTN3

6.57e-06352210656685
Pubmed

DNA-PK phosphorylation sites on Oct-1 promote cell survival following DNA damage.

POU2F1 PRKDC

6.57e-06352217213819
Pubmed

Expression of Interactive Genes Associated with Apoptosis and Their Prognostic Value for Ovarian Serous Adenocarcinoma.

AKT3 PRKDC

6.57e-06352227629740
Pubmed

G-CSF receptor positive neuroblastoma subpopulations are enriched in chemotherapy-resistant or relapsed tumors and are highly tumorigenic.

CSF3R PRKDC

6.57e-06352223687340
Pubmed

Activation of human neutrophils induces an interaction between the integrin beta 2-subunit (CD18) and the actin binding protein alpha-actinin.

ACTN2 ACTN3

6.57e-0635228104223
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

PREB IGF2R PDCD6IP BUB1B TCF25 PRKDC SEC63 EIF2A

9.68e-0670852839231216
Pubmed

Alpha-actinin and vinculin in human neutrophils: reorganization during adhesion and relation to the actin network.

ACTN2 ACTN3

1.31e-0545221629252
Pubmed

Disruption of alpha-actinin-integrin interactions at focal adhesions renders osteoblasts susceptible to apoptosis.

ACTN2 ACTN3

1.31e-05452216807302
Pubmed

G-CSF promotes the proliferation of developing cardiomyocytes in vivo and in derivation from ESCs and iPSCs.

CSF3R ACTN2

1.31e-05452220207226
Pubmed

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

PREB TCF25 GAN MAPK4 KLHL32 MAP3K12

1.93e-0537252622939624
Pubmed

Different MRF4 knockout alleles differentially disrupt Myf-5 expression: cis-regulatory interactions at the MRF4/Myf-5 locus.

ACTN2 ACTN3

2.19e-0555229268580
Pubmed

Deficiency of α-actinin-3 is associated with increased susceptibility to contraction-induced damage and skeletal muscle remodeling.

ACTN2 ACTN3

2.19e-05552221536590
Pubmed

p27Kip1 is expressed transiently in developing myotomes and enhances myogenesis.

ACTN2 ACTN3

2.19e-0555229438383
Pubmed

Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner.

ACTN2 ACTN3

2.19e-05552215841212
Pubmed

Myozenin: an alpha-actinin- and gamma-filamin-binding protein of skeletal muscle Z lines.

ACTN2 ACTN3

2.19e-05552211171996
Pubmed

The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin.

ACTN2 ACTN3

2.19e-05552212837758
Pubmed

Cell membrane expression of cardiac sodium channel Na(v)1.5 is modulated by alpha-actinin-2 interaction.

ACTN2 ACTN3

2.19e-05552219943616
Pubmed

Transposon mutagenesis identifies genetic drivers of Braf(V600E) melanoma.

CEP350 PRKDC

2.19e-05552225848750
Pubmed

The Catalytically Inactive Mutation of the Ubiquitin-Conjugating Enzyme CDC34 Affects its Stability and Cell Proliferation.

PREB PDCD6IP WDR6 PRKDC SEC63

2.82e-0523752529564676
Pubmed

Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion.

ACTN2 ACTN3

3.28e-05652218425115
Pubmed

The Alström syndrome protein, ALMS1, interacts with α-actinin and components of the endosome recycling pathway.

ACTN2 ACTN3

3.28e-05652222693585
Pubmed

The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase.

POU2F1 PRKDC

6.10e-05852211279128
Pubmed

Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies.

ACTN2 ACTN3

6.10e-05852211309420
Pubmed

The small muscle-specific protein Csl modifies cell shape and promotes myocyte fusion in an insulin-like growth factor 1-dependent manner.

ACTN2 ACTN3

6.10e-05852211381084
Pubmed

Mice deficient in alpha-actinin-4 have severe glomerular disease.

ACTN2 ACTN3

6.10e-05852212782671
Pubmed

The parafibromin tumor suppressor protein interacts with actin-binding proteins actinin-2 and actinin-3.

ACTN2 ACTN3

6.10e-05852218687124
Pubmed

CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function.

ACTN2 ACTN3

6.10e-05852220215401
Pubmed

DNA-PKcs, but not TLR9, is required for activation of Akt by CpG-DNA.

AKT3 PRKDC

7.84e-05952215678105
Pubmed

Genetic Steroid-Resistant Nephrotic Syndrome Overview

NUP160 PLCE1

7.84e-05952234436835
Pubmed

Calsarcins, a novel family of sarcomeric calcineurin-binding proteins.

ACTN2 ACTN3

7.84e-05952211114196
Pubmed

Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology.

ACTN2 ACTN3

9.79e-051052220368620
Pubmed

A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.

PREB IGF2R TCF25 GAN ACTN2 SEC63

1.03e-0450352636217030
Pubmed

COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas.

TBR1 MDGA1

1.20e-041152217828260
Pubmed

Lack of Diaph3 relaxes the spindle checkpoint causing the loss of neural progenitors.

BUB1B TBR1

1.20e-041152227848932
Pubmed

Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium.

ACTN2 ACTN3

1.20e-041152216585392
Pubmed

Molecular diversity of myofibrillar proteins: gene regulation and functional significance.

ACTN2 ACTN3

1.43e-04125228618961
Pubmed

Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase.

ACTN2 ACTN3

1.43e-041252215465019
Pubmed

The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions.

BUB1B NUP160

1.97e-041452217363900
Pubmed

HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.

IGF2R TCF25 TRIM65 PRKDC SEC63 NUP160

2.05e-0457152637167062
Pubmed

Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication.

POU2F1 PRKDC

2.27e-041552212393188
Pubmed

Differential expression of the actin-binding proteins, alpha-actinin-2 and -3, in different species: implications for the evolution of functional redundancy.

ACTN2 ACTN3

2.27e-041552211440986
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

ADAMTS12 PLXNA3 STRN3 TRNT1 UMODL1 PRKDC ACTN2 ACTN3 BAHCC1

2.60e-04144252935575683
Pubmed

DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis.

PRKDC TBR1

2.60e-041652228123024
Pubmed

Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality.

TBR1 MDGA1

2.94e-041752224441682
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

CEP350 PREB STRN3 LIN37 PDCD6IP BUB1B PRKDC NUP160

2.97e-04115552820360068
Pubmed

LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.

CEP350 STRN3 WDR6 BUB1B PRKDC EIF2A

3.73e-0463952623443559
Pubmed

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.

AKT3 LRRC24 TBR1

3.84e-049452325201988
Pubmed

Genome-wide association study of chronic periodontitis in a general German population.

IGF2R PDCD6IP ACTN2

4.08e-049652324024966
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

PREB WDR6 ENPP1 BUB1B TCF25 PLCE1

4.08e-0465052638777146
Pubmed

The caudo-ventral pallium is a novel pallial domain expressing Gdf10 and generating Ebf3-positive neurons of the medial amygdala.

TBR1 MDGA1

4.09e-042052229869132
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

PREB IGF2R PDCD6IP TCF25 PRKDC UBIAD1 SEC63

4.84e-0494252731073040
Pubmed

NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons.

AKT3 CNTN5

4.97e-042252221946561
Pubmed

p16 Protein and gigaxonin are associated with the ubiquitination of NFκB in cisplatin-induced senescence of cancer cells.

GAN PRKDC

4.97e-042252225331947
Pubmed

A radial glia-specific role of RhoA in double cortex formation.

TBR1 MDGA1

5.44e-042352222405202
Pubmed

Hypertonicity-responsive ubiquitin ligase RNF183 promotes Na, K-ATPase lysosomal degradation through ubiquitination of its β1 subunit.

PREB IGF2R WDR6 PRKDC UBIAD1

5.53e-0444952531732153
Pubmed

ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.

STRN3 OSBP PDCD6IP POU2F1 SEC63

5.65e-0445152536168627
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

PDCD6IP WDR6 TRIM65 PRKDC SEC63 EIF2A NUP160

5.90e-0497452728675297
Pubmed

Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs.

IGF2R PDCD6IP

5.93e-042452237100772
Pubmed

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells.

CEP350 SUPT20HL1 TRNT1 PRKDC NUP160

5.99e-0445752532968282
Pubmed

Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.

IGF2R PDCD6IP BUB1B

6.08e-0411052337219487
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

IGF2R PDCD6IP WDR6 ENPP1 TRIM65 PRKDC SEC63 NUP160

6.40e-04129752833545068
Pubmed

FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.

PREB OSBP IGF2R SEC63 NUP160

6.67e-0446852531056421
Pubmed

A Dynamic Unfolded Protein Response Contributes to the Control of Cortical Neurogenesis.

TBR1 EIF2A

6.96e-042652226651292
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

ADAMTS12 PLXNA3 STRN3 CAPN14 AKT3 MAPK4

7.50e-0473052634857952
Pubmed

Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2.

ACTN2 ACTN3

7.51e-042752236899856
Pubmed

Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.

IGF2R CSF3R PRKDC ACVRL1

7.79e-0427652428319085
Pubmed

SARS-CoV-2 NSP12 associates with TRiC and the P323L substitution acts as a host adaption.

STRN3 WDR6 PRKDC

7.83e-0412052337929963
Pubmed

HENA, heterogeneous network-based data set for Alzheimer's disease.

PDCD6IP ACTN2 NUP160

7.83e-0412052331413325
Pubmed

Integrin linked kinase (ILK) is required for lens epithelial cell survival, proliferation and differentiation.

AKT3 ACTN2

9.29e-043052224472646
Pubmed

UBR-box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target.

BUB1B PRKDC

9.29e-043052232867711
Pubmed

Experimental and Computational Analysis of Newly Identified Pathogenic Mutations in the Creatine Transporter SLC6A8.

PREB UBIAD1

1.34e-033652238070861
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

STRN3 OSBP TRNT1 PDCD6IP BUB1B PRKDC EIF2A NUP160

1.34e-03145552822863883
Pubmed

Proximity Mapping of CCP6 Reveals Its Association with Centrosome Organization and Cilium Assembly.

CEP350 STRN3

1.49e-033852236674791
GeneFamilyActinins

ACTN2 ACTN3

2.31e-0543621112
GeneFamilySulfotransferases, membrane bound

NDST3 CHST7

2.46e-0337362763
GeneFamilyKelch like|BTB domain containing

GAN KLHL32

3.16e-0342362617
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

LRRC24 CNTN5 MDGA1

3.99e-03161363593
ToppCellCerebellum-Neuronal-Excitatory|Cerebellum / BrainAtlas - Mouse McCarroll V32

REC114 BNIPL ACTN3 TBR1 MDGA1

4.02e-07128525c30ba14320e9b98c9af9e4cd5a8c55380bb9ffa9
Diseasefocal segmental glomerulosclerosis 1 (implicated_via_orthology)

ACTN2 ACTN3

2.80e-055502DOID:0111128 (implicated_via_orthology)
DiseaseNEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE

NUP160 PLCE1

1.19e-0330502C1868672
Diseasebasophil count

TRNT1 CSF3R PRKDC NUP160 PLCE1

1.33e-03483505EFO_0005090

Protein segments in the cluster

PeptideGeneStartEntry
PWRRCPKMVYRTQYL

UMODL1

66

Q5DID0
PWCSQYRRQLLKSLP

BUB1B

721

O60566
RNIPPARWKLTCYLC

BRD1

316

O95696
PPGTRVCAYWSQKSR

BAHCC1

1976

Q9P281
GLLLWCQRKTAPYRN

ACTN2

156

P35609
EPQPWKCYRAAARRL

BCDIN3D

196

Q7Z5W3
CWYPNPSARLTALRI

ACVRL1

471

P37023
RQLQYDPTPLTWSKC

ADAMTS12

421

P58397
RPKPNTFIIRCLQWT

AKT3

66

Q9Y243
WKLAPRYSRRASPQQ

CAPN14

11

A8MX76
YRWLKNGVPLSPQSR

CNTN5

421

O94779
RALQKRCLVPGWYAS

NDST3

736

O95803
WPLQRYARCIPSNTR

REC114

21

Q7Z4M0
RCTVNSNPPARFIWK

MDGA1

156

Q8NFP4
YPICRAWMRNSPSVR

LIN37

116

Q96GY3
NPRRCKWTEPYCVIA

LY6K

56

Q17RY6
TKWYRSPRLLLSPNN

MAPK4

191

P31152
AQVPPLSWIRQCYRT

BNIPL

266

Q7Z465
WQRTPSNELYKPLRA

PDCD6IP

476

Q8WUM4
PPSFRALLYKCWAQR

PLXNA3

776

P51805
ICNPLRYPVLISWRV

OR2T6

126

Q8NHC8
CQASGYPQPLVTWRK

LRRC24

281

Q50LG9
PQWQLALNPSERKYC

ENPP1

516

P22413
RTRIPYKPNYSLNLW

OSBP

406

P22059
WFCNRRQKEKRINPP

POU2F1

426

P14859
YDPRTQQWTAICPLK

GAN

441

Q9H2C0
PVWMKPCRINSSYFR

CEP350

2996

Q5VT06
TAYTLQIRCIRWPLP

CSF3R

301

Q99062
ILLRQCWNSKPRNRP

MAP3K12

341

Q12852
CWNSKPRNRPSFRQI

MAP3K12

346

Q12852
PRQREWRPQIYRKCT

SLC44A3

16

Q8N4M1
TCAPRLRVNNGYKIW

EIF2A

376

Q9BY44
KPLYRCDRWPCPNTV

GJA3

176

Q9Y6H8
CPRSTNKRSWLYRIL

HGD

51

Q93099
WRKYYINVCRPLNPV

IGF2R

806

P11717
RLWNPQEKLPCICTY

STRN3

611

Q13033
PVLNRRWSRLCLPKQ

TRNT1

11

Q96Q11
KRCLQRYSWPSVKPQ

SUPT20HL1

236

Q3ZLR7
PGKAQVYLCNRPLWL

TBR1

201

Q16650
WSYIDQKRNGPLLPC

PLCE1

361

Q9P212
PKSKPQLNRYLTRWA

MRPS18A

141

Q9NVS2
CLRLIRPEYAWIVQP

NUP160

1131

Q12769
LWCQRKTAPYRNVNV

ACTN3

166

Q08043
ALFRWRTNKVICSPP

CHST7

191

Q9NS84
HKRLRQPPPCYLTAW

PREB

271

Q9HCU5
RPPSQNYLSRVKNAW

SPDYC

246

Q5MJ68
CMWYRLRLLKPQPNI

SEC63

56

Q9UGP8
RLPQRSWRQKCASYV

UBIAD1

36

Q9Y5Z9
SWRQKCASYVLALRP

UBIAD1

41

Q9Y5Z9
RCRYLLPPSKQRWHT

WDR6

481

Q9NNW5
PLKRLLNTWTNRYPD

PRKDC

3156

P78527
PSTVCPLRRKLWQNY

TRIM65

316

Q6PJ69
PRQRQRVYPKCTWLT

TCF25

206

Q9BQ70
IYAQPVWQTRRTKPR

KLHL32

271

Q96NJ5