Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	actin binding	ESPN BIN1 ABI3 MAP1A ABI3BP CAMK2B ESPNL PTK2 XIRP2 MICAL2 PLEC AJUBA SAMD14 TNS1	1.76e-04	479	187	14	GO:0003779
GeneOntologyMolecularFunction	protein-macromolecule adaptor activity	CNKSR1 BIN1 ABI3 WWC3 MAP1A RBBP8 OBSL1 PEX6 GRB10 GON4L TUT1 CAMTA2 ATG2A HIF1AN KMT2D BAZ2A ATF7IP TONSL HELZ2 PKN1 DOT1L AJUBA PRDM16 TNS3	2.22e-04	1160	187	24	GO:0030674
GeneOntologyMolecularFunction	RNA uridylyltransferase activity	TUT4 TUT1	2.60e-04	3	187	2	GO:0050265
GeneOntologyMolecularFunction	actin filament binding	ESPN BIN1 ABI3 ABI3BP ESPNL XIRP2 PLEC AJUBA SAMD14	2.98e-04	227	187	9	GO:0051015
GeneOntologyMolecularFunction	molecular adaptor activity	CNKSR1 BIN1 ABI3 TANK WWC3 MAP1A RBBP8 OBSL1 PEX6 GRB10 GON4L E2F1 TUT1 CAMTA2 ATG2A HIF1AN KMT2D BAZ2A ATF7IP TONSL HELZ2 PKN1 DOT1L AJUBA PRDM16 TNS3	3.91e-04	1356	187	26	GO:0060090
GeneOntologyCellularComponent	centrosome	CYLD ATF5 CAMK2B OBSL1 RAP1GAP2 E2F1 TESK1 PTK2 IFT52 UBN1 CEP78 CTDP1 ZFYVE26 PPP1R35 AJUBA PLK1 CSPP1 PLK3 MTUS2 CCDC116	2.34e-05	770	189	20	GO:0005813
GeneOntologyCellularComponent	microtubule organizing center	CYLD ATF5 CAMK2B DZIP1L OBSL1 RAP1GAP2 E2F1 TESK1 PTK2 IFT52 MAPK15 UBN1 CEP78 CTDP1 ZFYVE26 PPP1R35 AJUBA PLK1 CSPP1 PLK3 MTUS2 CCDC116	3.11e-05	919	189	22	GO:0005815
GeneOntologyCellularComponent	dendritic shaft	ABI3 MAP1A ABI3BP ZNF804A GRIP2 SEZ6	5.61e-05	74	189	6	GO:0043198
GeneOntologyCellularComponent	cell leading edge	JCAD ABI3 ABI3BP BCAS3 INPP5E APC2 PLXND1 TESK1 CDC42BPB PTK2 NHS AJUBA PLEKHO1 PHLDB2	1.92e-04	500	189	14	GO:0031252
GeneOntologyCellularComponent	lamellipodium	ABI3 ABI3BP APC2 PLXND1 TESK1 CDC42BPB PTK2 NHS AJUBA	2.55e-04	230	189	9	GO:0030027
GeneOntologyCellularComponent	dendritic microtubule	MAP1A ZNF804A	4.82e-04	4	189	2	GO:1901588
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SEMA6C NDOR1 SETD1B BCAS3 INPP5E RAP1GAP2 PEX6 LAMA5 GRB10 PLXND1 GRIN2D ATG2A TEP1 TESK1 ZDHHC8 CDC42BPB CIC GGA3 KMT2D UBN1 CTDP1 SEC16A HELZ2 ANKRD11 ZFYVE26 PKN1 SNX15 LTBP3 PLEC DOT1L PRDM16 PLK3 PRRT4	2.56e-15	1105	192	33	35748872
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	JCAD ATF5 ACACB MAP1A APC2 ATG2A ZNF804A CIC PTK2 GGA3 ZNF469 FAM193A UBN1 XIRP2 YLPM1 TONSL PRRG4 PLEC AJUBA PLEKHO1	4.38e-13	430	192	20	35044719
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CYLD JCAD BCAS3 EXPH5 INPP5E MAP3K14 NELFB GRB10 SRSF11 LARP1B TESK1 CIC ITPKB SAMD11 SEC16A ANKRD11 NHS PLEC PLK1 CSPP1 PHLDB2 TNS3	2.91e-09	861	192	22	36931259
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	CYLD CAD SETD1B MAP1A RBBP8 CAMK2B OBSL1 ZNF318 CIC UBN1 NFATC2IP UBR5 ATF7IP TONSL SEC16A DOT1L	2.02e-07	588	192	16	38580884
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	BIN1 RBBP8 NELFB ZNF318 CIC URGCP KMT2D KANSL2 UBN1 BAZ2A YLPM1 CTDP1 SEC16A HELZ2 PKN1 PLEC PRRC2A PHLDB2	3.44e-07	774	192	18	15302935
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CYLD SETD1B OBSL1 RAP1GAP2 GRB10 GON4L CAMTA2 DCAF5 GGA3 UBR5 BAZ2A SEC16A TET3	4.93e-07	407	192	13	12693553
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	CYLD TOX OBSL1 CDC42BPB UBR5 SEC16A HELZ2 AUTS2 GRIP2 PRDM16	5.57e-07	225	192	10	12168954
Pubmed	Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes.	REC8 TEX12 PLK1 PLK3	6.19e-07	13	192	4	22854038
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	TANK MAP1A ZNF318 KMT2D FAM193A UBN1 UBR5 SEC16A PHLDB2	9.39e-07	184	192	9	32908313
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	CYLD DPYSL2 BIN1 CAD CAMK2B APC2 ZNF318 GRIN2D CDC42BPB PTK2 UBR5 ATF7IP YLPM1 SEC16A PKN1 TNS1 PRRC2A KCNT1 PHLDB2	1.87e-06	963	192	19	28671696
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	CYLD DPYSL2 TUT4 MAP1A BCAS3 LARP1B CDC42BPB PTK2 KIF20A FAM193A CEP78 YLPM1 PLEC MAP2K3 PRRC2A TNS3	3.05e-06	724	192	16	36232890
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	CNKSR1 DPYSL2 CAD NELFB GRB10 ANKZF1 NFATC2IP CTDP1 SEC16A NHS PKN1 PRRC2A PHLDB2	5.07e-06	503	192	13	16964243
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SEMA6C RALGDS INPP5E LAMA5 PLXND1 ATG2A URGCP GGA3 NRXN3 AUTS2 SDC3 IGSF9 KCNT1	8.68e-06	529	192	13	14621295
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ESPN DPYSL2 TUT4 HEBP2 NTF3 BCAS3 CAMK2B GRB10 SRSF11 TEP1 CDC42BPB PTK2 ITPKB GUCY1A1 MICAL2 LMLN ANKRD11 AUTS2 SDC3 IGSF9 PKN1 MAP2K3 TET3	8.92e-06	1489	192	23	28611215
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CYLD JCAD CNKSR1 DPYSL2 BIN1 APC2 OBSL1 RAP1GAP2 HUNK CDC42BPB DCAF5 PTK2 KANSL2 MICAL2 TPP1 YLPM1 LTBP3 PLEC OLIG2 PRRC2A MTUS2	9.75e-06	1285	192	21	35914814
Pubmed	Genomic analysis of mouse retinal development.	ROBO4 RALGDS BIN1 CDHR1 GRB10 IRF3 PTK2 KANSL2 BAZ2A CARF TONSL IGSF9 ZFYVE26 PLEC PLK1 SAMD14 MTUS2 SEZ6	1.33e-05	1006	192	18	15226823
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	CYLD IL16 TUT4 MAP1A GPT OBSL1 PEX6 ZNF318 TEP1 DCAF5 KIF20A ZNF469 ARHGEF33 C1orf226 UBR5 BAZ2A SEC16A PRDM16 PHLDB2	1.51e-05	1116	192	19	31753913
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	INPP5E CDC42BPB UBN1 SEC16A HELZ2 ANKRD11 PLEC AP4M1 PRRC2A TNS3	1.75e-05	332	192	10	37433992
Pubmed	A human MAP kinase interactome.	RALGDS MAP1A ABI3BP EXPH5 RAP1GAP2 LCP2 CDC42BPB CIC PTK2 ATF7IP PLEC TNS1	1.85e-05	486	192	12	20936779
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	CYLD MAP1A LARP1B FAM193A UBR5 SEC16A NHS TNS3	2.28e-05	209	192	8	36779422
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	DPYSL2 BIN1 MAP1A BCAS3 CAMK2B PTK2 PRRT3 PLEC SAMD14 PRRC2A	2.56e-05	347	192	10	17114649
Pubmed	PLK1 targets CtIP to promote microhomology-mediated end joining.	RBBP8 PLK1	3.03e-05	2	192	2	30202980
Pubmed	Mutations of the LIM protein AJUBA mediate sensitivity of head and neck squamous cell carcinoma to treatment with cell-cycle inhibitors.	AJUBA PLK1	3.03e-05	2	192	2	28126323
Pubmed	Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis.	KIF20A PLK1	3.03e-05	2	192	2	12939256
Pubmed	Characterization of the human IRF-3 promoter and its regulation by the transcription factor E2F1.	E2F1 IRF3	3.03e-05	2	192	2	19826915
Pubmed	MRCKβ links Dasm1 to actin rearrangements to promote dendrite development.	CDC42BPB IGSF9	3.03e-05	2	192	2	33933448
Pubmed	Tensin Regulates Fundamental Biological Processes by Interacting with Integrins of Tonsil-Derived Mesenchymal Stem Cells.	TNS1 TNS3	3.03e-05	2	192	2	35954177
Pubmed	The c-MYC-interacting proapoptotic tumor suppressor BIN1 is a transcriptional target for E2F1 in response to DNA damage.	BIN1 E2F1	3.03e-05	2	192	2	19629135
Pubmed	Cloning and sequencing of a novel human gene that encodes a putative target protein of Nesh-SH3.	ABI3 ABI3BP	3.03e-05	2	192	2	11501947
Pubmed	Polo box domain of Plk3 functions as a centrosome localization signal, overexpression of which causes mitotic arrest, cytokinesis defects, and apoptosis.	PLK1 PLK3	3.03e-05	2	192	2	16478733
Pubmed	A novel m6A reader Prrc2a controls oligodendroglial specification and myelination.	OLIG2 PRRC2A	3.03e-05	2	192	2	30514900
Pubmed	Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1.	RBBP8 PLK3	3.03e-05	2	192	2	25267294
Pubmed	Direct repression of the human IRF-3 promoter by E2F1.	E2F1 IRF3	3.03e-05	2	192	2	21225257
Pubmed	The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase.	PLK1 PLK3	3.03e-05	2	192	2	11931760
Pubmed	Unique subcellular distribution of phosphorylated Plk1 (Ser137 and Thr210) in mouse oocytes during meiotic division and pPlk1(Ser137) involvement in spindle formation and REC8 cleavage.	REC8 PLK1	3.03e-05	2	192	2	26654596
Pubmed	The E3 ubiquitin ligase UBR5 regulates centriolar satellite stability and primary cilia.	UBR5 CSPP1	3.03e-05	2	192	2	29742019
Pubmed	The tumor suppressor CYLD regulates entry into mitosis.	CYLD PLK1	3.03e-05	2	192	2	17495026
Pubmed	Knockout of the gene encoding the extracellular matrix protein SNED1 results in early neonatal lethality and craniofacial malformations.	E2F1 SNED1	3.03e-05	2	192	2	33012048
Pubmed	Repression of interferon regulatory factor 3 by the Epstein-Barr virus immediate-early protein Rta is mediated through E2F1 in HeLa cells.	E2F1 IRF3	3.03e-05	2	192	2	24535579
Pubmed	G protein-coupled receptor activation rapidly stimulates focal adhesion kinase phosphorylation at Ser-843. Mediation by Ca2+, calmodulin, and Ca2+/calmodulin-dependent kinase II.	CAMK2B PTK2	3.03e-05	2	192	2	15845548
Pubmed	USP45 and Spindly are part of the same complex implicated in cell migration.	DPYSL2 TUT4 CAD ABI3BP RBBP8 PLXND1 UBR5 PLEC	5.25e-05	235	192	8	30258100
Pubmed	Comprehensive binary interaction mapping of SH2 domains via fluorescence polarization reveals novel functional diversification of ErbB receptors.	GRB10 LCP2 SHD TNS1 TNS3	6.97e-05	77	192	5	22973453
Pubmed	Proximity labeling reveals dynamic changes in the SQSTM1 protein network.	TUT4 BCAS3 OBSL1 FAM193A SEC16A AUTS2 PKN1 PLK1 CSPP1	8.22e-05	322	192	9	39098523
Pubmed	Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast.	IGSF9 PRDM16	9.06e-05	3	192	2	35013309
Pubmed	Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma.	NDOR1 CIC	9.06e-05	3	192	2	29382756
Pubmed	BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations.	RBBP8 NELFB	9.06e-05	3	192	2	11739404
Pubmed	p53 Suppresses E2F1-dependent PLK1 expression upon DNA damage by forming p53-E2F1-DNA complex.	E2F1 PLK1	9.06e-05	3	192	2	24076372
Pubmed	Plk3 phosphorylates topoisomerase IIalpha at Thr(1342), a site that is not recognized by Plk1.	PLK1 PLK3	9.06e-05	3	192	2	18062778
Pubmed	The Deubiquitinase OTUB1 Is a Key Regulator of Energy Metabolism.	NDOR1 HIF1AN	9.06e-05	3	192	2	35163456
Pubmed	Dynamic coregulatory complex containing BRCA1, E2F1 and CtIP controls ATM transcription.	RBBP8 E2F1	9.06e-05	3	192	2	22832221
Pubmed	Loss of tonic T-cell receptor signals alters the generation but not the persistence of CD8+ memory T cells.	NDOR1 LCP2	9.06e-05	3	192	2	20884806
Pubmed	Growth hormone stimulates the tyrosine phosphorylation and association of p125 focal adhesion kinase (FAK) with JAK2. Fak is not required for stat-mediated transcription.	PTK2 TNS1	9.06e-05	3	192	2	9553131
Pubmed	Homeostatic division is not necessary for antigen-specific CD4+ memory T cell persistence.	NDOR1 LCP2	9.06e-05	3	192	2	22956580
Pubmed	The ALDH2, IGSF9, and PRDM16 Proteins as Predictive Biomarkers for Prognosis in Breast Cancer.	IGSF9 PRDM16	9.06e-05	3	192	2	36639264
Pubmed	Inducible transgenic expression of tripeptidyl peptidase 1 in a mouse model of late-infantile neuronal ceroid lipofuscinosis.	NDOR1 TPP1	9.06e-05	3	192	2	29408933
Pubmed	Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections.	CYLD MAP2K3	9.06e-05	3	192	2	17723219
Pubmed	T-cell receptor signals direct the composition and function of the memory CD8+ T-cell pool.	NDOR1 LCP2	9.06e-05	3	192	2	20847203
Pubmed	Oral ivermectin as an unexpected initiator of CreT2-mediated deletion in T cells.	NDOR1 LCP2	9.06e-05	3	192	2	22344272
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	CYLD ACACB NELFB ZNF318 PLXND1 CDC42BPB MFF KIF20A LIPE UBR5 ATF7IP SEC16A PKN1 AP4M1	1.16e-04	777	192	14	35844135
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ACACB RBBP8 ZNF318 CIC KMT2D FAM193A UBR5 ATF7IP SEC16A PLEC	1.20e-04	418	192	10	34709266
Pubmed	Human transcription factor protein interaction networks.	CYLD CAD ACACB GON4L E2F1 IRF3 ZNF318 DCAF5 CIC KMT2D KANSL2 UBN1 SAMD11 ATF7IP YLPM1 SEC16A AUTS2 DOT1L PRDM16 PRRC2A	1.36e-04	1429	192	20	35140242
Pubmed	Regulatory T cells require TCR signaling for their suppressive function.	NDOR1 LCP2	1.81e-04	4	192	2	25821220
Pubmed	Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like.	ESPN ESPNL	1.81e-04	4	192	2	26926603
Pubmed	Mislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody production.	NDOR1 LCP2	1.81e-04	4	192	2	20029045
Pubmed	Identification and assessment of PLK1/2/3/4 in lung adenocarcinoma and lung squamous cell carcinoma: Evidence from methylation profile.	PLK1 PLK3	1.81e-04	4	192	2	34080290
Pubmed	NIK is a component of the EGF/heregulin receptor signaling complexes.	MAP3K14 GRB10	1.81e-04	4	192	2	12853971
Pubmed	Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer.	TNS1 TNS3	1.81e-04	4	192	2	19194507
Pubmed	Epidermal growth factor modulates tyrosine phosphorylation of a novel tensin family member, tensin3.	PTK2 TNS3	1.81e-04	4	192	2	15140944
Pubmed	Regulation of E2F1-induced apoptosis by poly(ADP-ribosyl)ation.	BIN1 E2F1	1.81e-04	4	192	2	25257171
Pubmed	Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice.	NDOR1 KMT2D	1.81e-04	4	192	2	23826075
Pubmed	The scaffold protein TANK/I-TRAF inhibits NF-kappaB activation by recruiting polo-like kinase 1.	TANK PLK1	1.81e-04	4	192	2	20484576
Pubmed	Adenovirus E1A oncoprotein liberates c-Myc activity to promote cell proliferation through abating Bin1 expression via an Rb/E2F1-dependent mechanism.	BIN1 E2F1	1.81e-04	4	192	2	18348166
Pubmed	Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain.	PLK1 PLK3	1.81e-04	4	192	2	11901158
Pubmed	Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses.	NDOR1 LCP2	1.81e-04	4	192	2	21469089
Pubmed	Repair of noise-induced damage to stereocilia F-actin cores is facilitated by XIRP2 and its novel mechanosensor domain.	NDOR1 XIRP2	1.81e-04	4	192	2	37294664
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	CYLD JCAD ACACB NELFB FAM193A UBR5 SEC16A PLK1 CSPP1 PHLDB2	2.03e-04	446	192	10	24255178
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	CYLD BCAS3 RAP1GAP2 GRB10 IRF3 ATG2A ANKZF1 HIF1AN KIF20A CEP78 UBR5 SEC16A PPP1R35 AP4M1 AJUBA TNS3	2.26e-04	1038	192	16	26673895
Pubmed	DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.	ATF5 MAP1A ATF7IP	2.36e-04	22	192	3	12812986
Pubmed	BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62.	DPYSL2 MAP1A ZNF318 SEC16A PLEC TNS3	2.40e-04	156	192	6	32850835
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	JCAD CAD GRAMD1A CDC42BPB CIC KMT2D C1orf226 YLPM1 SEC16A NHS AJUBA PLK1 CSPP1 TNS1 PRRC2A TNS3	2.55e-04	1049	192	16	27880917
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	DPYSL2 CAD ZNF318 GGA3 KMT2D BAZ2A YLPM1 SEC16A DOT1L PLK1 PRRC2A	2.58e-04	549	192	11	38280479
Pubmed	Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.	ACACB MAP1A SRSF11 UBR5 YLPM1 TONSL SNX15	2.76e-04	226	192	7	31452512
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	RALGDS OBSL1 PEX6 GON4L SRSF11 COLGALT2 ANKZF1 URGCP PTK2 CEP78 TPP1 TONSL	2.87e-04	650	192	12	38777146
Pubmed	A protein-protein interaction map of the TNF-induced NF-κB signal transduction pathway.	CYLD TANK CAMK2B OBSL1 YOD1 YLPM1 PLEC PRRC2A	2.93e-04	302	192	8	30561431
Pubmed	Inactivation of tensin3 in mice results in growth retardation and postnatal lethality.	TNS1 TNS3	3.00e-04	5	192	2	15733665
Pubmed	Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1.	PLK1 PLK3	3.00e-04	5	192	2	19597481
Pubmed	The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1.	TNS1 TNS3	3.00e-04	5	192	2	17190795
Pubmed	Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin.	TICRR E2F1	3.00e-04	5	192	2	28439015
Pubmed	A gene affecting Wallerian nerve degeneration maps distally on mouse chromosome 4.	ESPN FUCA1	3.00e-04	5	192	2	8415768
Pubmed	Phosphorylation of synucleins by members of the Polo-like kinase family.	PLK1 PLK3	3.00e-04	5	192	2	19889641
Pubmed	A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling.	MAP3K14 IRF3	3.00e-04	5	192	2	30018345
Pubmed	TACI induces cIAP1-mediated ubiquitination of NIK by TRAF2 and TANK to limit non-canonical NF-kappaB signaling.	TANK MAP3K14	3.00e-04	5	192	2	20184394
Pubmed	Prickle1 promotes focal adhesion disassembly in cooperation with the CLASP-LL5β complex in migrating cells.	PRICKLE1 PHLDB2	3.00e-04	5	192	2	27378169
Pubmed	Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β.	TANK IRF3	3.00e-04	5	192	2	28159912
Pubmed	Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody.	PLK1 PLK3	3.00e-04	5	192	2	12493754
Pubmed	PLK1-mediated phosphorylation of PPIL2 regulates HR via CtIP.	RBBP8 PLK1	3.00e-04	5	192	2	36092721
Pubmed	Structural insights into the functions of TBK1 in innate antimicrobial immunity.	TANK IRF3	3.00e-04	5	192	2	23746807
Pubmed	The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response.	TANK IRF3	3.00e-04	5	192	2	18583960
Pubmed	PRRG4 promotes breast cancer metastasis through the recruitment of NEDD4 and downregulation of Robo1.	PTK2 PRRG4	3.00e-04	5	192	2	33037408
Pubmed	Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways.	PLK1 PLK3	3.00e-04	5	192	2	12242661
Interaction	TOP3B interactions	SEMA6C CAD NDOR1 SETD1B BCAS3 INPP5E PLEKHA4 RAP1GAP2 PEX6 LAMA5 GRB10 PLXND1 GRIN2D ATG2A TEP1 TESK1 ZDHHC8 CDC42BPB CIC GGA3 KMT2D UBN1 CTDP1 SEC16A HELZ2 ANKRD11 ZFYVE26 PKN1 SNX15 LTBP3 PLEC DOT1L PRDM16 PRRC2A PLK3 PRRT4	5.16e-08	1470	185	36	int:TOP3B
Interaction	YWHAG interactions	CYLD JCAD TICRR CAD BCAS3 EXPH5 INPP5E DZIP1L PLEKHA4 NELFB GRB10 SRSF11 LARP1B TESK1 ANKRD55 CIC PTK2 ITPKB GRID2IP CEP78 SAMD11 SEC16A ANKRD11 NHS PLK1 CSPP1 PHLDB2 TNS3	1.03e-05	1248	185	28	int:YWHAG
Interaction	DCAF4 interactions	TUT4 SETD1B ACACB E2F1 ATG2A LARP1B ZDHHC8 DCAF5 FAM193A UBR5 BAZ2A SEC16A HELZ2 PHLDB2	1.10e-05	378	185	14	int:DCAF4
Interaction	MAD2L1 interactions	CAD PLEKHA4 E2F1 ZNF318 DCAF5 CIC KIF20A UBR5 ATF7IP CTDP1 MAP2K3	2.23e-05	252	185	11	int:MAD2L1
Cytoband	9q34.3	RALGDS NDOR1 ARRDC1-AS1 INPP5E SEC16A KCNT1	5.96e-06	106	192	6	9q34.3
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	SETD1B KMT2D DOT1L PRDM16	5.61e-05	34	112	4	487
GeneFamily	Proline rich transmembrane proteins	PRRT3 PRRT4	2.26e-04	4	112	2	688
GeneFamily	SH2 domain containing	GRB10 LCP2 SHD TNS1 TNS3	4.12e-04	101	112	5	741
GeneFamily	Fibronectin type III domain containing	ROBO4 ABI3BP SNED1 ATF7IP IGSF9 ROS1	4.83e-04	160	112	6	555
GeneFamily	LIM domain containing	PRICKLE1 XIRP2 MICAL2 AJUBA	4.89e-04	59	112	4	1218
GeneFamily	Non-canonical poly(A) polymerases	TUT4 TUT1	7.83e-04	7	112	2	1318
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	TNS1 TNS3	1.04e-03	8	112	2	837
GeneFamily	Ankyrin repeat domain containing	ESPN ESPNL ANKZF1 ANKRD55 TONSL ANKRD11	3.97e-03	242	112	6	403
Coexpression	DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN	JCAD CAD OBSL1 LAMA5 FTSJ1 ATG2A ITPKB SEC16A FUCA1 PLEC MAP2K3	5.67e-06	276	189	11	M3063
Coexpression	GSE12845_IGD_POS_BLOOD_VS_DARKZONE_GC_TONSIL_BCELL_UP	INPP5E RAP1GAP2 ANKZF1 LIPE SULT2B1 TPP1 ROS1 PLEC MTUS2	1.34e-05	196	189	9	M3189
Coexpression	GSE27786_LIN_NEG_VS_NEUTROPHIL_DN	EMB INPP5E ATG2A HUNK CIC KMT2D SLC34A1 FAM217B PLEC	1.57e-05	200	189	9	M4795
Coexpression	LINDGREN_BLADDER_CANCER_CLUSTER_2B	DPYSL2 IL16 TOX MAP1A ABI3BP PRICKLE1 LCP2 PTK2 GUCY1A1 MICAL2 SDC3 TNS1	2.78e-05	389	189	12	M4995
Coexpression	MILI_PSEUDOPODIA_CHEMOTAXIS_UP	ATF5 DCAF5 MFF ANKRD11 PKN1 PHLDB2	3.31e-05	84	189	6	M15130
Coexpression	MILI_PSEUDOPODIA_CHEMOTAXIS_UP	ATF5 DCAF5 MFF ANKRD11 PKN1 PHLDB2	3.78e-05	86	189	6	MM825
ToppCell	Hippocampus-Neuronal-Inhibitory-iN2(Gad1Gad2)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	REC8 SEMA6C GRIN2D ANKRD55 NRXN3 NHS GRIP2 PRRT4	7.38e-07	169	192	8	c135d7ae0490d0024e0f4bd8c4ad42f6674a61da
ToppCell	Hippocampus-Neuronal-Inhibitory\|Hippocampus / BrainAtlas - Mouse McCarroll V32	REC8 SEMA6C GRIN2D ANKRD55 NRXN3 UBR5 NHS GRIP2	1.29e-06	182	192	8	b54ae650c04dfd0759c5f5e752b9bf684dd36516
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRABD2B ATF5 ZBTB7C LAMA5 YOD1 DOT1L TNS1 PHLDB2	1.46e-06	185	192	8	38486b69c48dc5e1c4e1488208fa8954a973eccb
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRABD2B ATF5 ZBTB7C LAMA5 YOD1 DOT1L TNS1 PHLDB2	1.46e-06	185	192	8	3c28b5ceba3cfdb6f7e32d5b42e03b6a81a7a658
ToppCell	pdx-Tumor_cells-T5\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	JCAD ZBTB7C EXPH5 GRAMD1A LAMA5 HUNK NRXN3 NHS	1.58e-06	187	192	8	7e376831a11ee72ed87abcdac631ca46ae29c250
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-4\|TCGA-Prostate / Sample_Type by Project: Shred V9	TRABD2B ACACB MAP3K14 ZNF469 LIPE NHS LTBP3 AJUBA	2.16e-06	195	192	8	5562665dd3beb70e2358aa32611a337bef5731c1
ToppCell	Epithelial_cells-AT1-AT2_cells\|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id	ABI3BP LAMA5 HCFC1R1 AJUBA PLEKHO1 TNS1 PHLDB2 TNS3	2.42e-06	198	192	8	fbc46b20bcd44f2083170aacbc6f5dd00fba685c
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma\|TCGA-Colorectal / Sample_Type by Project: Shred V9	CAD GRAMD1A FTSJ1 E2F1 SLC12A8 GRIN2D KIF20A AJUBA	2.51e-06	199	192	8	85b3b1ad01368dae4adbc9da7efc148e49992f69
ToppCell	TCGA-Colorectal-Primary_Tumor\|TCGA-Colorectal / Sample_Type by Project: Shred V9	CAD GRAMD1A FTSJ1 E2F1 SLC12A8 GRIN2D KIF20A AJUBA	2.51e-06	199	192	8	c7d6a8398f2419b726a0461585d1ee0561654e3b
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	NEURL2 TOX C2CD4A MAPK15 TPP1 NHS IGSF9	4.43e-06	152	192	7	6d02b50e9e9ecf820f84a79e46d153a4840a1cfe
ToppCell	Hippocampus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	REC8 SEMA6C GRIN2D NRXN3 UBR5 NHS GRIP2	6.47e-06	161	192	7	b81b346309f3facbfbebd91cae4c5b33c7bd24ef
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATF5 CDHR1 DZIP1L ANKZF1 ZDHHC8 CIC MAPK15	7.30e-06	164	192	7	b895674ed2df87db8fbfb30b7e31620945588491
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SEMA6C ROBO4 ERFL AQP7B PLXND1 LCP2 PLK1	7.90e-06	166	192	7	ec719368295133da2f7ff587c5329ed6db1dd56d
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	TRABD2B MAP1A NTF3 GUCY1A1 TONSL NHS GRIP2	8.22e-06	167	192	7	784776d1fcc098f84d3c2eca58fa56cb9428f434
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ROBO4 C14orf93 HEBP2 SLC12A8 PLXND1 KANSL2 C1orf226	1.03e-05	173	192	7	4968712af1cca8c932abd3323631d7dcaffd4a66
ToppCell	droplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l7\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ROBO4 ACACB PLXND1 LIPE NPW SBK3 SEZ6	1.12e-05	175	192	7	7be76d39e1a4f4ac709672cd2d409a2523a083ce
ToppCell	COVID-19_Mild-Neu_3\|COVID-19_Mild / 5 Neutrophil clusters in COVID-19 patients	MAP1A GON4L HIF1AN KMT2D NHS PKN1 TNS3	1.16e-05	176	192	7	2049767fd591045cfcf5b1071d80798e52843f27
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LAMA5 TUT1 GUCY1A1 GRIP2 TNS1 KCNT1 PHLDB2	1.16e-05	176	192	7	90f36f10c6ed440a0ca549f23219398853f1fbc3
ToppCell	368C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	TICRR NDOR1 RBBP8 ESPNL C1orf226 GUCY1A1 PLK1	1.20e-05	177	192	7	844017225e9039d1bc621a9630a30c2e9a51b36d
ToppCell	3'-Adult-LargeIntestine-Hematopoietic-T_cells-SELL+_CD4_T\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BIN1 IL16 LCP2 ANKZF1 ANKRD55 PLK3 SEZ6	1.20e-05	177	192	7	bb496fbec7cacc52847abe2b2714249c47879763
ToppCell	droplet-Bladder-Unstain-18m-Epithelial-granulocyte-monocyte_progenitor\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	REC8 TICRR E2F1 C2CD4A KIF20A SAMD11 PLK1	1.29e-05	179	192	7	804aa3899585fc7e662eff9f6d41f48655f16dd6
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ROBO4 GPT MAP3K14 PLXND1 SHD TONSL PRDM16	1.29e-05	179	192	7	dd94ebe69ade6f51b94058abe066216f0de9feda
ToppCell	facs-Lung-24m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C14orf93 ACACB ABI3BP PLXND1 TXLNB GUCY1A1 PRRT4	1.34e-05	180	192	7	2d608b9394d28d19cfc85c6ac94003d5177c8a92
ToppCell	10x5'-lymph-node_spleen-Myeloid_Mac-Cycling_Myeloid-Mac\|lymph-node_spleen / Manually curated celltypes from each tissue	DZIP1L CCL27 KIF20A C1orf226 SDC3 PLK1 TNS3	1.34e-05	180	192	7	4eea8366cdb82c356325ce88f09ad8b302c17a07
ToppCell	facs-Lung-24m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C14orf93 ACACB ABI3BP PLXND1 TXLNB GUCY1A1 PRRT4	1.34e-05	180	192	7	baa5825e6ce23a98d9c21d024a4b0ab8ba353d0c
ToppCell	facs-Lung-24m-Endothelial-arterial_endothelial\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	C14orf93 ACACB ABI3BP PLXND1 TXLNB GUCY1A1 PRRT4	1.34e-05	180	192	7	0f9b27054358c4737eed06c8ea01987cccc3cb55
ToppCell	Healthy_Control-Lymphoid-NK\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	JCAD TOX EMB CDHR1 SLC34A1 SPON2 AUTS2	1.49e-05	183	192	7	b41b1f32022c8632a638cf1c5523c9a24176f568
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NTF3 GRIN2D ANKRD55 NHS GRIP2 NPW PRRT4	1.49e-05	183	192	7	e3ffef2b57dc5b96466dccc9cd54ba326ccf378a
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JCAD CAD NDOR1 ABI3BP PRICKLE1 CDC42BPB TNS3	1.65e-05	186	192	7	37860daeecd6d412bd3797f30496a56da667fbd1
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DPYSL2 ASPHD1 GRB10 PLXND1 SDC3 TNS1 SECTM1	1.65e-05	186	192	7	f73cb91e74a806858650ae97f543fc779ba4cff8
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JCAD CAD NDOR1 ABI3BP PRICKLE1 CDC42BPB TNS3	1.65e-05	186	192	7	60830822d3de3147816693404fd03392e04c2b8e
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JCAD CAD NDOR1 ABI3BP PRICKLE1 CDC42BPB TNS3	1.65e-05	186	192	7	baebeffdd426ce767190ddefc857cc78e6a58d36
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_anti-infl\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DPYSL2 ASPHD1 GRB10 PLXND1 SDC3 TNS1 SECTM1	1.65e-05	186	192	7	8694ca16c9780729f4fba67ba20e35745f1eb4e9
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ABCA3 TOX NRXN3 MICAL2 AUTS2 ROS1 PRDM16	1.65e-05	186	192	7	e83718fabb057100835d3357df407f283d23fe16
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	JCAD ROBO4 IL16 ABI3 PLXND1 ITPKB PKN1	1.71e-05	187	192	7	50d5730e2cd4951d3ad0641fc81ae9f6ddabafe7
ToppCell	E18.5-samps-Mesenchymal\|E18.5-samps / Age Group, Lineage, Cell class and subclass	TRABD2B ABI3BP GRB10 GUCY1A1 SPON2 TNS1 TNS3	1.83e-05	189	192	7	0c18d3de4720759cf802eefb4d0ddde2a9246a1a
ToppCell	droplet-Heart\|droplet / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JCAD DPYSL2 ABI3 PLXND1 GUCY1A1 PLEKHO1 TNS1	2.03e-05	192	192	7	67a7e07a11091120edbccf739836235c422ec9c6
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIN2D HUNK LCP2 ANKRD55 NHS GRIP2 PRRT4	2.03e-05	192	192	7	67d6230e32d446dcb12047fae2c3f1faa80dd720
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Vein\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SEMA6C ABI3 ZBTB7C PLXND1 SAMD11 NPW FAM181B	2.03e-05	192	192	7	717f3d3bbee4d0f64ba1341ee2b00a407ba1e0f3
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ABI3 RAP1GAP2 CEP78 SPON2 AUTS2 MAP2K3 SERTAD3	2.17e-05	194	192	7	24837a27b0041fe8c348225fa8b09b127d743603
ToppCell	10x5'-bone_marrow-Hematopoietic_progenitors-HSC-MPP\|bone_marrow / Manually curated celltypes from each tissue	ROBO4 OBSL1 GRB10 E2F1 GUCY1A1 NPW PRRT4	2.17e-05	194	192	7	3a7e7acbddc63da44d9a04a5b52adf6934fc83dd
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TRABD2B NTF3 PLEKHA4 NHS GRIP2 ENPEP PHLDB2	2.47e-05	198	192	7	f261a37dd07976548b897af86df1d1a0dc069889
ToppCell	Tracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LAMA5 GRIP2 PRDM16 TNS1 ENPEP KCNT1 PHLDB2	2.47e-05	198	192	7	7dd874b09c81cc512ccc1e9b65f290a5f94d736e
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ABI3 TOX RAP1GAP2 CEP78 SPON2 AUTS2 SERTAD3	2.47e-05	198	192	7	faeef749a4b4bdc7f3edb6923e0e248e8b92c9d0
ToppCell	Sepsis-Leuk-UTI-Lymphocyte-T/NK-CD4+_CTL\|Leuk-UTI / Disease, condition lineage and cell class	TOX EMB CAMK2B COLGALT2 CEP78 SPON2 AUTS2	2.55e-05	199	192	7	b2609f9d716fdd04f35f0da7f8995d28d7df431d
ToppCell	Neuronal-Inhibitory-iB\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GRIN2D HUNK ANKRD55 NRXN3 NHS GRIP2 PRRT4	2.64e-05	200	192	7	45ddc5ef2caa87ada88327b63ba9b150a6bb3aa5
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-NP\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	IL16 TRABD2B TOX ABI3BP CDHR1 PHLDB2	5.17e-05	152	192	6	b6a7453fbf9f898e4f222b215907c9a110baa2f6
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_4\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ROBO4 TOX C2CD4A MAPK15 TPP1 IGSF9	5.17e-05	152	192	6	eb7ff36792c3c54ac88cfe976f84016b70b1a1d7
ToppCell	P28-Epithelial-epithelial_progenitor_cell-epi_progenitor\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	REC8 EMB MISP3 NPW NALF2 MTUS2	5.76e-05	155	192	6	be575a0096415705dba425002247289ff8f89474
ToppCell	5'-Adult-Appendix-Hematopoietic-B_cells-Cycling_B_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CAMK2B APC2 E2F1 ZNF318 ZNF804A UBR5	5.97e-05	156	192	6	203ef22eb76bd2b829b027c30af0557080f4006c
ToppCell	Children_(3_yrs)-Epithelial-basal_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ABI3BP NTF3 LAMA5 PTK2 SULT2B1 NHS	6.18e-05	157	192	6	6ee2692f705bdd93ba523dffaf2f0cd921b47e28
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-basal_intermediate_\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ABCA3 ASPHD1 EXPH5 NRXN3 GRID2IP IGSF9	6.40e-05	158	192	6	98712ed7e8e65e8c5ff9318cf0e0a04e271a055d
ToppCell	BAL-Severe-cDC_4\|Severe / Compartment, Disease Groups and Clusters	ZBTB7C ACACB INPP5E GPT MISP3 NHS	6.40e-05	158	192	6	73f66689ef59f71b14cb7141ca5951cc47fe57c1
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell_prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	JCAD ROBO4 EMB E2F1 GRIN2D TMEM121	6.87e-05	160	192	6	830e3ef8c9708d25872c3052a0b2682fa9372111
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell_prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	JCAD ROBO4 E2F1 PLXND1 NPW ERICH6	7.87e-05	164	192	6	1592a5becad7e0f3f990f0d7581d75fcfc7da023
ToppCell	10x5'-Liver-Hematopoietic_progenitors-Cycling_pre-Myeloid-2\|Liver / Manually curated celltypes from each tissue	TICRR NEURL2 DZIP1L KIF20A NHS PLK1	8.41e-05	166	192	6	a176e87aa6eec81d1fb79a028f759182d11b567d
ToppCell	10x5'-Liver-Hematopoietic_progenitors\|Liver / Manually curated celltypes from each tissue	TICRR NEURL2 DZIP1L KIF20A NHS PLK1	8.41e-05	166	192	6	ae967570248cf86ca3ddf55e33bcbb3e4e3684bc
ToppCell	Ionocyte-iono-3\|World / Class top	RAP1GAP2 GRB10 ZNF318 LARP1B FAM217B PLK1	8.41e-05	166	192	6	9c4a780f8af46d7552077c7a0ae0ab1b2413e5d4
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	IL16 TOX GRAMD1A LCP2 TXLNB TONSL	8.99e-05	168	192	6	6c758eb120faf06ff72d157b495e399191c79ec9
ToppCell	BAL-Control-cDC_6\|Control / Compartment, Disease Groups and Clusters	MAP1A KIF20A RCC1L NFATC2IP SAMD14 SEZ6	8.99e-05	168	192	6	65ec473cff748b334c0a66e33bc34a8465fe7631
ToppCell	Control\|World / group, cell type (main and fine annotations)	ABCA3 TOX EXPH5 NRXN3 MICAL2 ROS1	8.99e-05	168	192	6	a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TEP1 ANKRD55 NEURL3 SLC34A1 SDC3 PLEKHO1	9.29e-05	169	192	6	735655e75511c5c41aca667909e8bb52a0ad7fc6
ToppCell	Frontal_cortex-Neuronal-Inhibitory\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SEMA6C GRIN2D ANKRD55 NRXN3 NHS GRIP2	9.29e-05	169	192	6	78eb70dd916724e476eabccf18fb7fcec4210308
ToppCell	PND01-03-samps-Mesenchymal-Pericyte-pericyte_F\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	CAD HUNK SHD GUCY1A1 FAM181B AJUBA	9.59e-05	170	192	6	71718dcebd48105994c313bb55babc70301170a0
ToppCell	Globus_pallidus-Endothelial-MURAL-M1(Rgs5Acta2)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	TRABD2B ATF5 NTF3 TXLNB ENPEP PHLDB2	1.06e-04	173	192	6	51328a60ffaf34fa0f7df6084d348b5efc9917f5
ToppCell	5'-Adult-SmallIntestine-Epithelial-neuro-epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ASPHD1 CAMK2B NPW FAM181B MTUS2 SEZ6	1.06e-04	173	192	6	30fa8c14c8a1f546f380132c0c28a61e6a2f9fc4
ToppCell	droplet-Heart-4Chambers-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ROBO4 ABI3 ESPNL PLXND1 ITPKB LIPE	1.06e-04	173	192	6	9a04271c51fae34f547db3206f9ff5857686e45c
ToppCell	Globus_pallidus-Endothelial-MURAL\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	TRABD2B ATF5 NTF3 TXLNB ENPEP PHLDB2	1.06e-04	173	192	6	b77cd5dbda3a206922f20224f4e10a3bf712f7db
ToppCell	3'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ROBO4 ABI3 TMEM121 SAMD11 GRIP2 SAMD14	1.06e-04	173	192	6	b57d14e2c2368304cb903562d06ce8228f53857c
ToppCell	facs-Lung-24m-Mesenchymal-myofibroblast\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ESPN TRABD2B MAP1A SHD GUCY1A1 SPON2	1.09e-04	174	192	6	a7ade7372e83edd4e3983e77f8417b51f0b47340
ToppCell	droplet-Bladder-Unstain-18m-Hematologic-nan\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABI3 TOX EMB LCP2 SULT2B1 SAMD11	1.09e-04	174	192	6	773329bb91b97578df138446cf62101dd0dad758
ToppCell	droplet-Marrow-BM-1m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABI3 ANKZF1 DCAF5 C1orf226 MICAL2 PRDM16	1.12e-04	175	192	6	c1c722db42da9b8a2a46e516ddb83d9be5e2e504
ToppCell	COVID-19-Heart-VSMC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ZBTB7C NTF3 NHS PRDM16 ENPEP KCNT1	1.12e-04	175	192	6	1125f0d3a5b2388fa77a820dea0288e824d84a82
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_A2\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	OBSL1 LAMA5 GRB10 FCRL1 TXLNB PLK1	1.16e-04	176	192	6	052b54c4337ca728974a106b6dbd3b72dd28eb23
ToppCell	368C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TICRR RBBP8 KIF20A C1orf226 GUCY1A1 PLK1	1.20e-04	177	192	6	26c25d10aa511b64cc7db43a8deea7b5d31bca96
ToppCell	droplet-Lung-nan-3m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APC2 PTK2 NRXN3 GUCY1A1 AJUBA ENPEP	1.20e-04	177	192	6	8684d47a547e2a06496f15e8da0200ecddc431e0
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DZIP1L KIF20A GUCY1A1 AJUBA PLK1 SEZ6	1.20e-04	177	192	6	2b63f0529ef73e0eede9b7ef1f08b0a0426a9c82
ToppCell	droplet-Lung-nan-3m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APC2 PTK2 NRXN3 GUCY1A1 AJUBA ENPEP	1.20e-04	177	192	6	65709bd546cb1ec6aa2ddd8b2adb46e174eb9a9a
ToppCell	5'-Adult-LymphNode-Endothelial-blood_vessel_EC-arterial_capillary\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	JCAD ROBO4 LAMA5 AQP7B ITPKB LIPE	1.23e-04	178	192	6	360d7a987f91d6d721487a921824057ec31a7332
ToppCell	Children_(3_yrs)-Epithelial-basal_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ABI3BP NTF3 LAMA5 PTK2 SULT2B1 NHS	1.23e-04	178	192	6	fba2e38c05cbf031e0c6d47b1602575fea734a57
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAP1A CAMK2B NRXN3 PRRT3 IGSF9 KCNT1	1.23e-04	178	192	6	1bddbc083c36657bd6910f7466126ab325e88176
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAP1A CAMK2B NRXN3 PRRT3 IGSF9 KCNT1	1.23e-04	178	192	6	a74e5a390cbeaca9de1fdb7b2a0e50783bd202dd
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c03-MKI67\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TICRR ABCA3 E2F1 KIF20A GRID2IP SPON2	1.23e-04	178	192	6	dbde3305e0c6a81593fe614e3f2e746b32cc16a7
ToppCell	droplet-Lung-LUNG-30m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRABD2B APC2 HUNK PTK2 GUCY1A1 AJUBA	1.27e-04	179	192	6	36ad18f52e175ab636ceaa3be81212fa362c96c1
ToppCell	droplet-Lung-LUNG-30m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRABD2B APC2 HUNK PTK2 GUCY1A1 AJUBA	1.27e-04	179	192	6	bfc226bcf0b93525992344f968268a261d86fcbf
ToppCell	COVID-19-Heart-VSMC\|Heart / Disease (COVID-19 only), tissue and cell type	TRABD2B ZBTB7C NTF3 NHS PRDM16 ENPEP	1.27e-04	179	192	6	a69ad6912b5c10bb9f9d800f724c792341e9bab1
ToppCell	human_hepatoblastoma-Tumor_cells-T6\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ZBTB7C COLGALT2 NRXN3 XIRP2 AUTS2 NHS	1.27e-04	179	192	6	14fc8ccb6b215063d747643f47d780d2b237eb67
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NTF3 GRIN2D ANKRD55 NHS GRIP2 PRRT4	1.27e-04	179	192	6	97ba67a856680f24846244c0b92c886cc0e79537
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ROBO4 GRAMD1A LAMA5 PLXND1 NEURL3 HELZ2	1.31e-04	180	192	6	d8ef44710a77ad0fc03243428e5e1dc4d41200cb
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IL16 EXPH5 CAMK2B NRXN3 SAMD14 KCNT1	1.31e-04	180	192	6	6ac62bf1251978c8c12e715f7b73144fca619794
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	ABCA3 TOX HUNK MICAL2 AUTS2 ROS1	1.31e-04	180	192	6	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	droplet-Heart-nan-24m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRABD2B NTF3 BCAS3 GUCY1A1 GRIP2 ENPEP	1.31e-04	180	192	6	78fdcfb3fdbf36469cae78407cda5bd0996930d8
ToppCell	10x5'-bone_marrow-Hematopoietic_progenitors-Cycling_pre-Myeloid-1\|bone_marrow / Manually curated celltypes from each tissue	ASPHD1 KIF20A C1orf226 PRRG4 PLEC PLK1	1.35e-04	181	192	6	ccd0ed30cea3fb41d34f28b3e8d80a94493bef3c
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ESPN TRABD2B GPT AQP7B NHS ENPEP	1.39e-04	182	192	6	4a9c13932e7163fd37a3dcc4c6ca3bbea5372459
ToppCell	10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-LMPP\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	NDOR1 TOX MAP1A BCAS3 SHD CARF	1.39e-04	182	192	6	69b5cae6fe3bbb0fc60bd2f71b6cfa6cbb0b00ee
ToppCell	Basal\|World / shred by cell class for mouse tongue	TRABD2B RBBP8 LAMA5 PLEC AJUBA TNS1	1.43e-04	183	192	6	c6729a207526ff4aa48176207b9353176f631fea
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HEBP2 PLEKHA4 C2CD4A TESK1 NEURL3 SECTM1	1.43e-04	183	192	6	2dde2fb48e7d31271c2f6b1dd74b2ab0b2cb520c
ToppCell	droplet-Kidney-nan-21m-Mesenchymal-podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATF5 ZBTB7C OBSL1 CEP78 MICAL2 SAMD14	1.43e-04	183	192	6	ad7421623e4c0c5ba02eec56e9bdae43ebb88d90
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Sncg-Sncg_Vip_Itih5\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LAMA5 GRID2IP FAM181B TNS1 TNS3	1.47e-04	116	192	5	605bd4fdf547cc41783e99cd78425760ef6461ef
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Rorb\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	ESPN EXPH5 PLXND1 XIRP2 IGSF9	1.47e-04	116	192	5	9c92e714e210a2f29a9e228653d4c990ec643c72
Drug	Disopyramide [3737-09-5]; Up 200; 11.8uM; MCF7; HT_HG-U133A	RALGDS BIN1 ATF5 MAP1A E2F1 TUT1 ZNF318 ANKZF1 GGA3 NALF2 PRRC2A	8.24e-07	198	188	11	7035_UP
Drug	Amikacin hydrate [37517-28-5]; Up 200; 6.6uM; PC3; HT_HG-U133A	ROBO4 IL16 CAMK2B SNED1 NRXN3 SULT2B1 BAZ2A OLIG2 TNS1 ENPEP	5.62e-06	196	188	10	6715_UP
Drug	colcemid; Up 200; 11.7uM; MCF7; HT_HG-U133A_EA	DPYSL2 ABCA3 RAP1GAP2 GON4L ZNF318 PLXND1 PTK2 MAP2K3 PRRC2A	3.00e-05	190	188	9	1103_UP
Drug	Quinacrine dihydrochloride dihydrate [6151-30-0]; Up 200; 7.8uM; HL60; HG-U133A	CYLD DPYSL2 TANK E2F1 LCP2 TESK1 HIF1AN ATF7IP MAP2K3	3.12e-05	191	188	9	1563_UP
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A	INPP5E LAMA5 E2F1 PLXND1 ANKZF1 BAZ2A MICAL2 ZFYVE26 PRRC2A	3.25e-05	192	188	9	6986_DN
Drug	Guanabenz acetate [23256-50-0]; Down 200; 13.8uM; PC3; HG-U133A	BIN1 TANK CAMK2B GRB10 TESK1 URGCP NFATC2IP PRRG4 SERTAD3	3.39e-05	193	188	9	1961_DN
Drug	Naltrexone hydrochloride dihydrate [16676-29-2]; Down 200; 9.6uM; HL60; HG-U133A	PEX6 SRSF11 ZNF318 CAMTA2 HIF1AN CIC YLPM1 PRRG4 TNS1	3.39e-05	193	188	9	1363_DN
Drug	PHA-00745360 [351320-33-7]; Down 200; 10uM; PC3; HT_HG-U133A	TOX ACACB BCAS3 GON4L E2F1 PLXND1 NRXN3 CSPP1 PLK3	3.53e-05	194	188	9	4559_DN
Drug	Zuclopenthixol hydrochloride [633-59-0]; Down 200; 9.2uM; MCF7; HT_HG-U133A	ASPHD1 E2F1 SRSF11 TUT1 ZNF318 ANKZF1 BAZ2A PLEC CSPP1	3.82e-05	196	188	9	7356_DN
Drug	Benzonatate [104-31-4]; Down 200; 6.6uM; MCF7; HT_HG-U133A	CYLD TANK EXPH5 TUT1 HIF1AN CIC PKN1 PLEC MAP2K3	3.82e-05	196	188	9	1679_DN
Drug	Triamterene [396-01-0]; Down 200; 15.8uM; HL60; HT_HG-U133A	CYLD PLXND1 HIF1AN KIF20A SPON2 PRRG4 SNX15 PLK1 CSPP1	3.82e-05	196	188	9	1861_DN
Drug	Scoulerine [6451-73-6]; Up 200; 12.2uM; MCF7; HT_HG-U133A	BIN1 TOX CDHR1 MAP3K14 GGA3 BAZ2A CARF HCFC1R1 PLEC	3.82e-05	196	188	9	5536_UP
Drug	Tetracaone hydrochloride [136-47-0]; Down 200; 13.2uM; MCF7; HT_HG-U133A	C14orf93 TUT4 ACACB ABI3BP CAMK2B TUT1 BAZ2A PRRG4 SECTM1	3.82e-05	196	188	9	2888_DN
Drug	Cefoperazone dihydrate; Down 200; 5.8uM; PC3; HT_HG-U133A	CYLD JCAD CNKSR1 BIN1 GON4L E2F1 ZNF318 CTDP1 MAP2K3	3.82e-05	196	188	9	6323_DN
Drug	Serotonin hydrochloride [153-98-0]; Up 200; 18.8uM; MCF7; HT_HG-U133A	REC8 IL16 ACACB NTF3 CAMK2B GPT BAZ2A TPP1 PLK3	3.98e-05	197	188	9	3311_UP
Drug	Isoniazid [54-85-3]; Down 200; 29.2uM; MCF7; HT_HG-U133A	BIN1 ASPHD1 EXPH5 E2F1 TUT1 CIC BAZ2A SDC3 MAP2K3	3.98e-05	197	188	9	7197_DN
Drug	Sulfadimethoxine [122-11-2]; Down 200; 12.8uM; MCF7; HT_HG-U133A	CYLD C14orf93 GRB10 SLC12A8 CAMTA2 ITPKB CSPP1 PRRC2A PLK3	4.14e-05	198	188	9	3441_DN
Drug	Suramin sodium salt; Up 200; 10uM; MCF7; HT_HG-U133A	CYLD C14orf93 TUT4 GRB10 TPP1 CTDP1 TNS1 PLK3 SECTM1	4.14e-05	198	188	9	7524_UP
Drug	Norfloxacin [70458-96-7]; Up 200; 12.6uM; PC3; HT_HG-U133A	JCAD ROBO4 SETD1B MAP1A BCAS3 PEX6 SULT2B1 SDC3 PLK3	4.14e-05	198	188	9	2090_UP
Drug	Fludrocortisone acetate [514-36-3]; Down 200; 9.4uM; PC3; HT_HG-U133A	C14orf93 E2F1 PLXND1 TEP1 BAZ2A MICAL2 PRRG4 TNS1 PLK3	4.14e-05	198	188	9	3785_DN
Drug	Tiratricol, 3,3',5-triiodothyroacetic acid [51-24-1]; Up 200; 6.4uM; MCF7; HT_HG-U133A	GRB10 TUT1 ZNF318 TEP1 BAZ2A SDC3 PLEC ENPEP PRRC2A	4.14e-05	198	188	9	7011_UP
Drug	Phentolamine hydrochloride [73-05-2]; Down 200; 12.6uM; MCF7; HT_HG-U133A	C14orf93 BIN1 TUT4 GPT ITPKB YLPM1 PLEC TNS1 SECTM1	4.30e-05	199	188	9	3860_DN
Drug	troglitazone; Up 200; 10uM; HL60; HT_HG-U133A	BIN1 IL16 ABCA3 ACACB CAMK2B CDHR1 SNED1 DOT1L SECTM1	4.30e-05	199	188	9	6191_UP
Drug	Bacampicillin hydrochloride [37661-08-8]; Up 200; 8uM; MCF7; HT_HG-U133A	CYLD GRB10 E2F1 ZNF318 ATG2A CIC GGA3 PRRC2A PLK3	4.30e-05	199	188	9	3273_UP
Drug	Methamphetamine	DPYSL2 BIN1 NEURL2 ACACB MAP1A GPT OBSL1 PUSL1 PEX6 GON4L TUT1 CAMTA2 GRIN2D CIC KIF20A FAM193A BAZ2A ANKRD11 GRIP2 PLEC MAP2K3 PRDM16 PLEKHO1 TNS1 PLK3 CCDC116	9.13e-05	1401	188	26	ctd:D008694
Drug	trichostatin A, Streptomyces sp.; Down 200; 1uM; PC3; HT_HG-U133A	SETD1B SLC12A8 ZNF804A URGCP KIF20A GUCY1A1 HCFC1R1 AP4M1	9.86e-05	173	188	8	5950_DN
Drug	5182598; Up 200; 25uM; MCF7; HT_HG-U133A_EA	RALGDS BIN1 ZNF318 ANKZF1 TPP1 SDC3 MAP2K3 PRRC2A	1.16e-04	177	188	8	976_UP
Drug	Azaguanine-8 [134-58-7]; Down 200; 26.2uM; PC3; HT_HG-U133A	TUT4 TANK EXPH5 ZNF318 NFATC2IP ANKRD11 ZFYVE26 PLK1	1.35e-04	181	188	8	1791_DN
Drug	wortmannin; Down 200; 1uM; MCF7; HT_HG-U133A_EA	BIN1 ASPHD1 E2F1 ITPKB SULT2B1 SDC3 MAP2K3 NALF2	1.81e-04	189	188	8	869_DN
Drug	vinblastine sulfate; Up 200; 0.1uM; PC3; HT_HG-U133A	JCAD BIN1 TOX CAMTA2 HIF1AN FAM193A YLPM1 HCFC1R1	2.02e-04	192	188	8	7556_UP
Drug	Etofenamate [30544-47-9]; Up 200; 10.8uM; MCF7; HT_HG-U133A	CYLD TUT4 ASPHD1 ACACB CIC SNED1 PRDM16 PLK3	2.02e-04	192	188	8	4108_UP
Drug	Forskolin, from Coleus forskohlii; Down 200; 0.5uM; PC3; HT_HG-U133A	CYLD ABCA3 SETD1B TMEM121 KIF20A BAZ2A AP4M1 TNS1	2.02e-04	192	188	8	7104_DN
Drug	Rapamycin; Up 200; 0.1uM; MCF7; HT_HG-U133A	CNKSR1 NDOR1 SETD1B YLPM1 CTDP1 PRRG4 ENPEP SECTM1	2.02e-04	192	188	8	6958_UP
Drug	Progesterone [57-83-0]; Down 200; 12.8uM; PC3; HT_HG-U133A	CYLD C14orf93 ACACB PEX6 E2F1 TMEM121 CSPP1 PLK3	2.09e-04	193	188	8	6646_DN
Drug	Tocopherol (R,S) [10191-41-0]; Up 200; 9.2uM; MCF7; HT_HG-U133A	NDOR1 CAMK2B CCL27 LIPE BAZ2A AUTS2 PRRG4 TNS1	2.17e-04	194	188	8	4961_UP
Drug	Clorsulon [60200-06-8]; Down 200; 10.6uM; PC3; HT_HG-U133A	CYLD CNKSR1 BIN1 PEX6 E2F1 SLC12A8 ITPKB PRRG4	2.25e-04	195	188	8	7264_DN
Drug	Naringenine [480-41-1]; Up 200; 14.6uM; MCF7; HT_HG-U133A	BIN1 OBSL1 RAP1GAP2 GRB10 ATG2A CIC SULT2B1 SPON2	2.25e-04	195	188	8	3278_UP
Drug	ST021200; Up 200; 10uM; PC3; HT_HG-U133A	JCAD BIN1 ABCA3 BAZ2A YLPM1 PKN1 PLK1 PLEKHO1	2.25e-04	195	188	8	7559_UP
Drug	Meptazinol hydrochloride [59263-76-2]; Up 200; 14.8uM; HL60; HT_HG-U133A	ABI3BP CAMK2B RAP1GAP2 SLC12A8 BAZ2A YLPM1 LTBP3 TNS1	2.25e-04	195	188	8	2906_UP
Drug	Spaglumic acid [4910-46-7]; Down 200; 13.2uM; HL60; HT_HG-U133A	EXPH5 E2F1 ANKRD55 CIC PTK2 TPP1 ZFYVE26 PKN1	2.25e-04	195	188	8	2962_DN
Drug	Cyanocobalamin [68-19-9]; Up 200; 3uM; MCF7; HT_HG-U133A	CYLD RALGDS BIN1 SETD1B OBSL1 CAMTA2 CIC PRDM16	2.32e-04	196	188	8	3252_UP
Drug	ICI182,780; Up 200; 1uM; MCF7; HT_HG-U133A	CNKSR1 BIN1 OBSL1 TEP1 TPP1 AUTS2 PLEC SECTM1	2.32e-04	196	188	8	5926_UP
Drug	Lasalocid sodium salt [25999-20-6]; Up 200; 6.6uM; MCF7; HT_HG-U133A	NDOR1 MAP1A OBSL1 TEP1 GGA3 TPP1 SPON2 TNS1	2.32e-04	196	188	8	3360_UP
Drug	rosiglitazone; Up 200; 10uM; MCF7; HT_HG-U133A	SETD1B SLC12A8 CCL27 TESK1 SPON2 SDC3 TNS1 PLK3	2.32e-04	196	188	8	5230_UP
Drug	Debrisoquin sulfate [581-88-4]; Up 200; 9uM; MCF7; HT_HG-U133A	ASPHD1 LAMA5 TESK1 CDC42BPB CIC GGA3 BAZ2A MAP2K3	2.32e-04	196	188	8	5288_UP
Drug	aspirin, USP; Down 200; 100uM; MCF7; HT_HG-U133A	CAMTA2 ITPKB BAZ2A YLPM1 CTDP1 HCFC1R1 ENPEP PRRC2A	2.32e-04	196	188	8	1629_DN
Drug	Hesperidin [520-26-3]; Down 200; 6.6uM; HL60; HT_HG-U133A	ATF5 PEX6 PLXND1 BAZ2A TPP1 SPON2 PKN1 PRRC2A	2.32e-04	196	188	8	1294_DN
Drug	Bergenin monohydrate [477-90-7]; Down 200; 11.6uM; MCF7; HT_HG-U133A	ASPHD1 EXPH5 CAMTA2 ATG2A ANKZF1 MICAL2 MAP2K3 CSPP1	2.32e-04	196	188	8	7224_DN
Drug	Xylazine [7361-61-7]; Up 200; 18.2uM; PC3; HT_HG-U133A	SNED1 SULT2B1 BAZ2A MICAL2 TPP1 AUTS2 PLEKHO1 TNS1	2.32e-04	196	188	8	4066_UP
Drug	Phthalylsulfathiazole [85-73-4]; Down 200; 10uM; MCF7; HT_HG-U133A	ASPHD1 PLXND1 TESK1 HIF1AN CIC ITPKB BAZ2A CSPP1	2.32e-04	196	188	8	5249_DN
Drug	Zardaverine [101975-10-4]; Down 200; 15uM; MCF7; HT_HG-U133A	BIN1 EXPH5 E2F1 CIC TMEM121 SDC3 PLEC NALF2	2.32e-04	196	188	8	4793_DN
Drug	Diethylstilbestrol [56-53-1]; Down 200; 15uM; MCF7; HT_HG-U133A	E2F1 PLXND1 CIC ITPKB ZFYVE26 AP4M1 MAP2K3 CSPP1	2.32e-04	196	188	8	3429_DN
Drug	Mesoridazine besylate [32672-69-8]; Down 200; 7.4uM; PC3; HT_HG-U133A	CNKSR1 BIN1 ACACB SLC12A8 ZNF318 KIF20A MAP2K3 CSPP1	2.32e-04	196	188	8	7256_DN
Drug	Dichlorphenamide [120-97-8]; Down 200; 13.2uM; HL60; HT_HG-U133A	REC8 EXPH5 INPP5E E2F1 HIF1AN HCFC1R1 PLEC CSPP1	2.41e-04	197	188	8	3027_DN
Drug	Rapamycin; Up 200; 0.1uM; MCF7; HT_HG-U133A	CYLD C14orf93 CAMK2B APC2 ZNF318 TEP1 YLPM1 ENPEP	2.41e-04	197	188	8	6940_UP
Drug	Harmaline hydrochloride dihydrate [6027-98-1]; Down 200; 14uM; MCF7; HT_HG-U133A	CYLD GRB10 ANKZF1 BAZ2A TPP1 CSPP1 ENPEP PLK3	2.41e-04	197	188	8	4968_DN
Drug	rofecoxib; Down 200; 10uM; HL60; HG-U133A	CYLD RALGDS CNKSR1 ACACB ZNF318 CAMTA2 KMT2D ANKRD11	2.41e-04	197	188	8	371_DN
Drug	CP-320650-01 [172079-28-6]; Down 200; 10uM; PC3; HT_HG-U133A	CYLD TOX YOD1 NRXN3 SDC3 PLEKHO1 CSPP1 TNS1	2.41e-04	197	188	8	4557_DN
Drug	Flavoxate hydrochloride [3717-88-2]; Down 200; 9.4uM; PC3; HT_HG-U133A	CNKSR1 BIN1 ZNF318 TMEM121 BAZ2A YLPM1 PKN1 CSPP1	2.41e-04	197	188	8	6326_DN
Drug	15(S)-15-methyl Prostaglandin E2; Up 200; 10uM; MCF7; HT_HG-U133A	CYLD MAP1A INPP5E CAMK2B GRB10 LIPE TPP1 CTDP1	2.41e-04	197	188	8	7521_UP
Drug	estradiol, USP; Down 200; 0.1uM; PC3; HT_HG-U133A	RALGDS CNKSR1 BIN1 ACACB ABI3BP E2F1 SULT2B1 MAP2K3	2.41e-04	197	188	8	1208_DN
Drug	Evoxine [522-11-2]; Up 200; 11.6uM; MCF7; HT_HG-U133A	BIN1 IL16 TOX MAP1A OBSL1 SNED1 GUCY1A1 PRDM16	2.41e-04	197	188	8	6041_UP
Drug	Mycophenolic acid [24280-93-1]; Down 200; 12.4uM; MCF7; HT_HG-U133A	BIN1 ASPHD1 GRB10 ITPKB ANKRD11 PLK1 CSPP1 TNS3	2.41e-04	197	188	8	4137_DN
Drug	Spiramycin [8025-81-8]; Down 200; 4.8uM; HL60; HT_HG-U133A	BIN1 WWC3 INPP5E GON4L E2F1 ANKZF1 PLEC PRRC2A	2.41e-04	197	188	8	2558_DN
Drug	Rapamycin; Down 200; 0.1uM; HL60; HT_HG-U133A	ATF5 BCAS3 GRB10 ANKRD55 SNED1 HCFC1R1 TNS1 ENPEP	2.41e-04	197	188	8	2702_DN
Drug	ICI 182,780; Up 200; 1uM; HL60; HT_HG-U133A	RAP1GAP2 CAMTA2 HIF1AN BAZ2A PRRG4 PLEC OLIG2 SECTM1	2.41e-04	197	188	8	2665_UP
Drug	valdecoxib; Down 200; 10uM; PC3; HT_HG-U133A	JCAD RALGDS IL16 CAMK2B PLXND1 MICAL2 CTDP1 PLEKHO1	2.41e-04	197	188	8	6408_DN
Drug	Iproniazide phosphate [305-33-9]; Down 200; 14.4uM; PC3; HT_HG-U133A	CYLD ACACB TUT1 PLXND1 HIF1AN YLPM1 SDC3 CSPP1	2.41e-04	197	188	8	6359_DN
Drug	ICI 182,780; Down 200; 0.01uM; HL60; HT_HG-U133A	BCAS3 MAP3K14 RAP1GAP2 SLC12A8 PLXND1 HIF1AN URGCP HCFC1R1	2.41e-04	197	188	8	2698_DN
Drug	Laudanosine (R,S) [1699-51-0]; Up 200; 11.2uM; MCF7; HT_HG-U133A	IL16 NTF3 CAMK2B APC2 ZNF804A ANKRD55 TMEM121 BAZ2A	2.49e-04	198	188	8	2890_UP
Drug	tetraethylenepentamine pentahydrochloride; Down 200; 100uM; MCF7; HG-U133A	TUT4 INPP5E MAP3K14 E2F1 BAZ2A SLC34A1 AP4M1 SERTAD3	2.49e-04	198	188	8	406_DN
Drug	Diazoxide [364-98-7]; Down 200; 17.4uM; MCF7; HT_HG-U133A	ASPHD1 SLC12A8 TUT1 TESK1 CIC BAZ2A MICAL2 YLPM1	2.49e-04	198	188	8	7168_DN
Drug	Flurbiprofen [5104-49-4]; Down 200; 16.4uM; MCF7; HT_HG-U133A	CNKSR1 TUT4 MAP3K14 GRB10 ZNF318 TESK1 HIF1AN PLEKHO1	2.49e-04	198	188	8	6472_DN
Drug	Hydrochlorothiazide [58-93-5]; Down 200; 13.4uM; MCF7; HT_HG-U133A	CYLD BIN1 TUT4 E2F1 CIC TMEM121 PRRG4 PLK3	2.49e-04	198	188	8	4970_DN
Drug	Trimetazidine dihydrochloride [13171-25-0]; Up 200; 11.8uM; MCF7; HT_HG-U133A	BIN1 GPT SLC12A8 CCL27 CTDP1 TNS1 PRRC2A PLK3	2.49e-04	198	188	8	5479_UP
Drug	Neostigmine bromide [114-80-7]; Down 200; 13.2uM; MCF7; HT_HG-U133A	GON4L TUT1 ZNF318 TEP1 SULT2B1 BAZ2A CTDP1 PRRG4	2.49e-04	198	188	8	3294_DN
Drug	estradiol, USP; Up 200; 0.01uM; HL60; HT_HG-U133A	CYLD BIN1 ACACB EXPH5 LAMA5 TESK1 GGA3 BAZ2A	2.49e-04	198	188	8	6200_UP
Drug	Guanabenz acetate [23256-50-0]; Up 200; 13.8uM; MCF7; HT_HG-U133A	JCAD CNKSR1 BIN1 SLC12A8 ZNF318 TEP1 ITPKB PLK3	2.49e-04	198	188	8	1544_UP
Drug	(-)-MK 801 hydrogen maleate [77086-19-2]; Down 200; 11.8uM; HL60; HT_HG-U133A	RALGDS EXPH5 CAMK2B PEX6 E2F1 ANKRD55 SNX15 TNS1	2.49e-04	198	188	8	3081_DN
Drug	Dimethisoquin hydrochloride [2773-92-4]; Down 200; 13uM; MCF7; HT_HG-U133A	EXPH5 GON4L ZNF318 HIF1AN TMEM121 NFATC2IP SDC3 PLEC	2.49e-04	198	188	8	4791_DN
Drug	haloperidol; Down 200; 10uM; MCF7; HT_HG-U133A_EA	CNKSR1 EXPH5 GRB10 SRSF11 TESK1 MAP2K3 CSPP1 ENPEP	2.49e-04	198	188	8	983_DN
Drug	estradiol, USP; Up 200; 0.1uM; PC3; HT_HG-U133A	NTF3 CDHR1 CCL27 CIC LIPE TPP1 OLIG2 TNS1	2.49e-04	198	188	8	4432_UP
Drug	Methacholine chloride [62-51-1]; Up 200; 20.4uM; MCF7; HT_HG-U133A	CYLD C14orf93 BIN1 IL16 CAMK2B TUT1 ANKZF1 PLK3	2.49e-04	198	188	8	6248_UP
Drug	Acebutolol hydrochloride [34381-68-5]; Down 200; 10.8uM; MCF7; HT_HG-U133A	CYLD ABI3BP SLC12A8 TUT1 TMEM121 TPP1 SDC3 PRRG4	2.49e-04	198	188	8	4976_DN
Drug	Hydrocortisone base [50-23-7]; Up 200; 11uM; MCF7; HT_HG-U133A	CYLD CAMK2B E2F1 CIC TMEM121 PRRG4 PRDM16 CSPP1	2.49e-04	198	188	8	5284_UP
Drug	Benzydamine hydrochloride [132-69-4]; Down 200; 11.6uM; MCF7; HT_HG-U133A	CNKSR1 ASPHD1 GRB10 SLC12A8 TUT1 URGCP BAZ2A MAP2K3	2.49e-04	198	188	8	7169_DN
Drug	PF-00539758-00 [351321-34-1]; Down 200; 10uM; PC3; HT_HG-U133A	BIN1 NTF3 TUT1 YOD1 BAZ2A TPP1 SDC3 TNS1	2.49e-04	198	188	8	6421_DN
Drug	Atractyloside potassium salt [102130-43-8]; Up 200; 5uM; PC3; HT_HG-U133A	CYLD RALGDS NTF3 PLXND1 LIPE NRXN3 CARF TNS1	2.49e-04	198	188	8	3695_UP
Drug	AC1OAGKB	E2F1 IRF3 TEP1 PTK2 MAPK15 PKN1 ROS1 TNS1	2.49e-04	198	188	8	CID006857406
Drug	Sulfanilamide [63-74-1]; Down 200; 23.2uM; MCF7; HT_HG-U133A	CNKSR1 ASPHD1 CAMK2B GON4L TUT1 ITPKB SDC3 AP4M1	2.58e-04	199	188	8	6810_DN
Drug	sulindac sulfone; Down 200; 50uM; MCF7; HG-U133A	ROBO4 ACACB E2F1 TUT1 CIC NFATC2IP PLEC TNS1	2.58e-04	199	188	8	309_DN
Drug	Buflomedil hydrochloride [35543-24-9]; Up 200; 11.6uM; MCF7; HT_HG-U133A	BIN1 ATF5 MAP1A GRB10 CCL27 ITPKB BAZ2A PRRC2A	2.58e-04	199	188	8	3274_UP
Drug	Methoxy-6-harmalan [3589-73-9]; Down 200; 18.6uM; PC3; HT_HG-U133A	CYLD ABCA3 TOX ANKZF1 YLPM1 SDC3 PRRG4 TNS1	2.58e-04	199	188	8	6355_DN
Drug	Lysergol [602-85-7]; Up 200; 15.8uM; HL60; HT_HG-U133A	REC8 C14orf93 SLC12A8 TEP1 CIC MICAL2 PKN1 TNS1	2.58e-04	199	188	8	1325_UP
Drug	Heliotrine [303-33-3]; Up 200; 12.8uM; MCF7; HT_HG-U133A	BIN1 NDOR1 ACACB CAMK2B ANKRD55 KMT2D NRXN3 AUTS2	2.58e-04	199	188	8	3615_UP
Drug	Ticarcillin sodium [4697-14-7]; Up 200; 9.4uM; MCF7; HT_HG-U133A	ROBO4 RALGDS TANK GRB10 PLXND1 TMEM121 ITPKB ENPEP	2.58e-04	199	188	8	7185_UP
Drug	Aspartic acid, N-acetyl (R,S) [997-55-7]; Up 200; 22.8uM; MCF7; HT_HG-U133A	REC8 CAMTA2 CIC GGA3 BAZ2A TPP1 CTDP1 TNS1	2.58e-04	199	188	8	3265_UP
Drug	Methiothepin maleate [19728-88-2]; Down 200; 8.4uM; PC3; HT_HG-U133A	BIN1 MAP1A PEX6 ANKZF1 SDC3 HCFC1R1 CSPP1 TNS1	2.58e-04	199	188	8	6312_DN
Drug	Flurbiprofen [5104-49-4]; Up 200; 16.4uM; MCF7; HT_HG-U133A	CYLD CNKSR1 SETD1B CAMK2B BAZ2A SDC3 NALF2 PLK3	2.58e-04	199	188	8	5269_UP
Drug	Probenecid [57-66-9]; Up 200; 14uM; HL60; HT_HG-U133A	ABI3BP GPT SLC12A8 TUT1 CCL27 TESK1 SULT2B1 YLPM1	2.58e-04	199	188	8	2464_UP
Disease	Intellectual Disability	RALGDS CNKSR1 INPP5E CAMK2B APC2 PEX6 GON4L GRIN2D CIC TPP1 SERAC1 FUCA1 AP4M1 TET3	7.64e-07	447	181	14	C3714756
Disease	Profound Mental Retardation	RALGDS CNKSR1 INPP5E PEX6 GON4L CIC AP4M1	2.51e-05	139	181	7	C0020796
Disease	Mental Retardation, Psychosocial	RALGDS CNKSR1 INPP5E PEX6 GON4L CIC AP4M1	2.51e-05	139	181	7	C0025363
Disease	Mental deficiency	RALGDS CNKSR1 INPP5E PEX6 GON4L CIC AP4M1	2.51e-05	139	181	7	C0917816
Disease	autosomal recessive nonsyndromic deafness 36 (implicated_via_orthology)	ESPN ESPNL	3.74e-05	2	181	2	DOID:0110494 (implicated_via_orthology)
Disease	eosinophil count	ZBTB7C ST20-AS1 EMB RBBP8 MAP3K14 RAP1GAP2 GRB10 LCP2 ZDHHC8 ITPKB FAM193A NEURL3 ATF7IP SEC16A HELZ2 ANKRD11 SDC3 FUCA1 LTBP3 PLEC AJUBA OLIG2 TET3	4.41e-05	1488	181	23	EFO_0004842
Disease	Malignant neoplasm of breast	ABCA3 TANK APC2 E2F1 ZNF318 COLGALT2 GRIN2D TESK1 CIC GGA3 KMT2D LIPE FAM217B NHS ZFYVE26 TNS1 ENPEP PRRC2A	1.16e-04	1074	181	18	C0006142
Disease	brain measurement, neuroimaging measurement	DPYSL2 PRR23A TANK GRB10 SLC12A8 HIF1AN PTK2 CARF IGSF9 PLEC PRDM16 TNS1	1.61e-04	550	181	12	EFO_0004346, EFO_0004464
Disease	Adenocarcinoma of large intestine	CAMK2B CDC42BPB UBR5 PKN1 ROS1	3.20e-04	96	181	5	C1319315
Disease	restrictive cardiomyopathy (is_implicated_in)	KIF20A MAP2K3	5.52e-04	6	181	2	DOID:397 (is_implicated_in)
Disease	lung small cell carcinoma (is_implicated_in)	E2F1 PTK2 KMT2D	6.64e-04	28	181	3	DOID:5409 (is_implicated_in)
Disease	epidermolysis bullosa simplex (is_implicated_in)	EXPH5 PLEC	7.70e-04	7	181	2	DOID:4644 (is_implicated_in)
Disease	immature platelet measurement	JCAD DCAF5 BAZ2A PLEC PRDM16	8.54e-04	119	181	5	EFO_0803541
Disease	Autism Spectrum Disorders	CIC NRXN3 ANKRD11 TET3	1.88e-03	85	181	4	C1510586
Disease	gastric adenocarcinoma (is_implicated_in)	KMT2D UBR5	1.98e-03	11	181	2	DOID:3717 (is_implicated_in)
Disease	myeloid white cell count	JCAD BIN1 SETD1B ST20-AS1 INPP5E GRAMD1A MAP3K14 CIC KANSL2 GUCY1A1 MICAL2 DOT1L TNS3 SERTAD3	2.00e-03	937	181	14	EFO_0007988
Disease	body surface area	TICRR GRB10 COLGALT2 HIF1AN NRXN3 UBN1 ANKRD11 AUTS2 LTBP3 PLEC DOT1L	2.17e-03	643	181	11	EFO_0022196
Disease	brain disease (is_implicated_in)	IRF3 MFF	2.37e-03	12	181	2	DOID:936 (is_implicated_in)
Disease	ovary epithelial cancer (is_marker_for)	PLK1 PLK3	2.79e-03	13	181	2	DOID:2152 (is_marker_for)
Disease	Alzheimer disease	BIN1 ABI3 PRICKLE1 NTF3 BCAS3 PEX6 ANKRD55 NRXN3 PLEC	3.18e-03	485	181	9	MONDO_0004975
Disease	Acute Confusional Senile Dementia	DPYSL2 BIN1 ABI3 TPP1	3.28e-03	99	181	4	C0546126
Disease	Alzheimer's Disease, Focal Onset	DPYSL2 BIN1 ABI3 TPP1	3.28e-03	99	181	4	C0750900
Disease	Alzheimer Disease, Early Onset	DPYSL2 BIN1 ABI3 TPP1	3.28e-03	99	181	4	C0750901
Disease	Presenile dementia	DPYSL2 BIN1 ABI3 TPP1	3.28e-03	99	181	4	C0011265
Disease	Alzheimer Disease, Late Onset	DPYSL2 BIN1 ABI3 TPP1	3.28e-03	99	181	4	C0494463
Disease	Familial Alzheimer Disease (FAD)	DPYSL2 BIN1 ABI3 TPP1	3.40e-03	100	181	4	C0276496
Disease	Alzheimer's Disease	DPYSL2 BIN1 ABI3 TPP1	3.52e-03	101	181	4	C0002395
Disease	cortical thickness	DPYSL2 PRR23A INPP5E ESPNL SLC12A8 ZNF318 PLXND1 HIF1AN ZNF469 UBN1 YLPM1 AUTS2 IGSF9 PLEC TNS1	3.71e-03	1113	181	15	EFO_0004840
Disease	Diuretic use measurement	TICRR BCAS3 ZNF318 GUCY1A1 ENPEP	3.96e-03	169	181	5	EFO_0009928
Disease	mean reticulocyte volume	CAD GRB10 ZNF318 ZNF469 IFT52 ATF7IP TONSL HELZ2 PLK1 MAP2K3 PRDM16 SERTAD3	3.98e-03	799	181	12	EFO_0010701
Disease	lung small cell carcinoma (is_marker_for)	E2F1 PTK2	4.24e-03	16	181	2	DOID:5409 (is_marker_for)
Disease	Schizoaffective disorder-bipolar type	ZNF804A NRXN3	4.24e-03	16	181	2	EFO_0009965
Disease	vitamin C measurement	BCAS3 SLC34A1	4.24e-03	16	181	2	EFO_0600003
Disease	intraocular pressure measurement	JCAD BCAS3 CAMTA2 MFF ZNF469 LTBP3 NALF2 PRDM16 TNS1	4.35e-03	509	181	9	EFO_0004695
Disease	mortality	JCAD RAP1GAP2 NT5C1B NRXN3 AUTS2	4.37e-03	173	181	5	EFO_0004352
Disease	Agents acting on the renin-angiotensin system use measurement	TICRR BCAS3 ZNF318 GUCY1A1 AUTS2 PRDM16 ENPEP	4.78e-03	335	181	7	EFO_0009931
Disease	Sjogren's syndrome (implicated_via_orthology)	MAP3K14 E2F1	4.79e-03	17	181	2	DOID:12894 (implicated_via_orthology)
Disease	schizophrenia, inflammatory bowel disease	TOX IRF3	5.37e-03	18	181	2	EFO_0003767, MONDO_0005090
Disease	immature platelet fraction	DCAF5 BAZ2A PLEC PRDM16	5.41e-03	114	181	4	EFO_0009187
Disease	monocyte percentage of leukocytes	SEMA6C BIN1 ST20-AS1 INPP5E MAP3K14 ANKRD55 CTDP1 SEC16A PRDM16 SERTAD3 SECTM1	5.66e-03	731	181	11	EFO_0007989
Disease	breast cancer (is_marker_for)	TUT4 BCAS3 KMT2D MAPK15 MAP2K3	5.79e-03	185	181	5	DOID:1612 (is_marker_for)
Disease	Antihypertensive use measurement	ZNF318 GUCY1A1 AUTS2 PRDM16 ENPEP PHLDB2	6.04e-03	265	181	6	EFO_0009927
Disease	platelet crit	JCAD MAP1A BCAS3 EXPH5 MAP3K14 LAMA5 ZNF318 DQX1 YLPM1 PRRG4 PLEC DOT1L PRDM16	6.07e-03	952	181	13	EFO_0007985

Protein segments in the cluster

Peptide	Gene	Start	Entry
SLQPPASPQLPRSLD	NT5C1B	176	Q96P26
RPPLDQPLELAPLTT	C2orf42	556	Q9NWW7
ALLDLVVSPPAPTDP	GPT	356	P24298
PPLTPETLQTLFSAP	ERFL	161	A0A1W2PQ73
LPIRQEPSSFRAVPP	CTDP1	796	Q9Y5B0
FEPSLRTLPSIGPPS	ERICH6	231	Q7L0X2
LLSPDPTAAFLLPPS	CCL27	16	Q9Y4X3
NSPESSLLPRAPALP	CDHR1	781	Q96JP9
FPTSLEPTSDLPPLG	CCDC116	336	Q8IYX3
PPDQASTRLPAELEP	ANKRD11	2191	Q6UB99
PPQEELPTRVSSPVF	RBBP8	316	Q99708
TRALPLPQSLPPDFR	AJUBA	96	Q96IF1
LPQSLPPDFRLEPTA	AJUBA	101	Q96IF1
LRPSADPIFEPRQLP	BAZ2A	1481	Q9UIF9
IPPQDPASPSFTLLS	ARGFX	26	A6NJG6
PFRSINIPEPVLPSE	ARHGEF33	141	A8MVX0
FAEPLEIRPSPPTSR	CAMTA2	301	O94983
TTSLFPLFPNPGPRE	ABCA3	181	Q99758
LLSQESRTEPTRPPP	ANKRD55	316	Q3KP44
DARIPLPLDSFPVPV	CEP78	606	Q5JTW2
PSPVLQPRDPSSTLE	DOT1L	901	Q8TEK3
PLPTNESQPLSLFPT	BCAS3	911	Q9H6U6
LSETRPEALPPPSSN	FAM193A	561	P78312
LDLPSFAPPAQLAPT	ATG2A	1006	Q2TAZ0
ITVSDPPFDTQPRPD	GRAMD1A	706	Q96CP6
LSDDLPSPLPFRLFP	AP4M1	286	O00189
PSFDLPQPPVLDTLD	ATF5	146	Q9Y2D1
VPPPTDSARLLNTSP	MTUS2	571	Q5JR59
PSPVSLPLDRPQETR	RCC1L	161	Q96I51
SVDPRLPSPFDIPQI	REC8	141	O95072
LQRNFPDPDTPPLTI	YOD1	271	Q5VVQ6
EVFQRPPTLEELSPP	ABI3	251	Q9P2A4
TPISFETPSNPPLAR	ACACB	631	O00763
RTLQVALPSTPAEPP	DZIP1L	556	Q8IYY4
ASDPELQPAERPLPS	OBSL1	106	O75147
FPPPPLLATRRSLED	ESPNL	341	Q6ZVH7
SFLNPPLPPSIDDRD	MAP1A	2451	P78559
PLDFLDLERPPTTPQ	MFF	126	Q9GZY8
PRPPPALSLDIASDS	INPP5E	191	Q9NRR6
RSPRAPEPALEPESL	NPW	116	Q8N729
SFPTRPIPRLSQSDP	HIF1AN	36	Q9NWT6
PSRLLLQPSPQRADP	IGLJ1	1	A0A0A0MT76
PLSPDPTTPDFLNSL	DPYSL2	306	Q16555
PRQTLDALLPPDTSP	MAPK15	261	Q8TD08
IPSEQQFDPPRPLES	HEBP2	111	Q9Y5Z4
NPSRDPPPSIFTFIA	AQP7B	231	A0A075B734
FLPDLPSAPFVPRDA	ASPHD1	191	Q5U4P2
PESPQEELLSRPAPA	JCAD	1121	Q9P266
FQPDSPLPSVSPALS	ESPN	686	B1AK53
PPETDPPATNLTRAL	LMLN	606	Q96KR4
LINPPPDTRLEPSDI	KCNT1	1176	Q5JUK3
ELETPCLTLSPSPFP	CARF	381	Q8N187
PTSPQDCPRTLLSPL	PLXND1	746	Q9Y4D7
LRVLEPFPTETPPLA	PEX6	6	Q13608
DVLPPPSQLPSARER	CSPP1	1116	Q1MSJ5
DLSDSERIPIPPSPL	FAM217B	96	Q9NTX9
FISLPQLPPSAVPAE	FUCA1	441	P04066
SIASSRLPQESPPLP	IL16	556	Q14005
RLPQESPPLPESRDS	IL16	561	Q14005
EDPLATPPIATRAPS	NRXN3	1346	Q9Y4C0
TEPQLRAPSPDPDLV	AUTS2	311	Q8WXX7
ELDTDLFPRPRSPSP	DCAF5	541	Q96JK2
LFPRPRSPSPEDESS	DCAF5	546	Q96JK2
AAETPALELPLPSVP	NELFB	561	Q8WX92
PPVSLSTPDPLFQLS	LMLN2	611	A0A1B0GTW7
SDNQRRLSPPFPLEP	EXPH5	1746	Q8NEV8
LQPPSGTELSPFSPI	GGA3	656	Q9NZ52
QSLQRLFEPTTPAPP	NALF2	151	O75949
LRPPDSLSRAPAEFP	NALF2	166	O75949
LLDPRANPSQPPSDL	ENPEP	561	Q07075
PLRARNLPPSFFTEP	FAM181B	221	A6NEQ2
RPPTAVDPDAEPTLL	LAMA5	1266	O15230
DLPLSAVPPSQEERP	CDC42BPB	1606	Q9Y5S2
IQPDLSDRPTPSDPQ	PCDHGB3	671	Q9Y5G1
SPRVLLSDSTPLEPP	NTF3	101	P20783
EAAAPSRPPTLLVEP	NEURL2	131	Q9BR09
SFLELEAPPLPQPRV	DQX1	391	Q8TE96
LQPREPDVSSPTRLP	NDOR1	276	Q9UHB4
LEELPPATPSPRLAL	SLC34A1	616	Q06495
DDLSSPPSALPTPQF	PRICKLE1	796	Q96MT3
PARTQPSLIADETPP	APC2	1561	O95996
ELATLSQPPRSATPP	APC2	1851	O95996
LPTLQPAVFPPSFRE	IFT52	331	Q9Y366
LDLESEPTPEPQPRS	GRID2IP	481	A4D2P6
PDLLLFATPQAPRPT	E2F1	61	Q01094
PSPADPRVLSLLSAP	ANKZF1	516	Q9H8Y5
DPLRSLPSPLPQEFT	FCRL1	341	Q96LA6
RSVLQETFPRLDPPP	C1orf226	106	A1L170
PSDRLPSAEAQLLPP	C14orf93	476	Q9H972
PSADRPLEASLPPLQ	HUNK	681	P57058
ALPAVPPEARTSFPL	GON4L	1071	Q3T8J9
PQPQRLPPEAASTSL	ATF7IP	1146	Q6VMQ6
PDLPPSRSAVEIAPT	LTBP3	556	Q9NS15
PELELALTPARAPSP	RALGDS	271	Q12967
PPSPLLFDPSLTLED	KANSL2	421	Q9H9L4
RTSSLPAIPNPFPEL	GRB10	131	Q13322
FSPALPPLRSPCSEL	HCFC1R1	86	Q9NWW0
SPPSPLFLEAPSRQA	ARRDC1-AS1	71	Q9H2J1
APDSPFTSPPLREEI	EMB	36	Q6PCB8
ISTDFDRSSPPLQPP	CYLD	391	Q9NQC7
LPPPTSLDTVPSRDE	COLGALT2	611	Q8IYK4
LLFPSNRETLPDPCP	HELZ2	1756	Q9BYK8
LSSPPLVCFIEPDSP	GRIP2	481	Q9C0E4
LDLDFDPLPPVTSPV	BIN1	391	O00499
PRALPRPATTQEPDI	SDC3	256	O75056
SPPSFPVEISDRLPA	SLC12A8	511	A0AV02
LLPPDTLPLRPAVDS	SBK3	211	P0C264
APSLSELDLRPPSPI	PRRT3	796	Q5FWE3
ELRPLPPSPIEDSQL	C3orf56	206	Q8N813
PPSSRVPFPERLEAE	C2CD4A	231	Q8NCU7
PPRSVPPTDFSQLID	LARP1B	301	Q659C4
LSPSTPSDVNFLLPP	LIPE	901	Q05469
EEATPSPSPPLKRQF	MICAL2	766	O94851
EPLPLSSLEPAPARN	MAP3K14	741	Q99558
LRSPSLDNPTPFPNL	IRF3	171	Q14653
PNPTPPRNLDSRTFI	MAP2K3	36	P46734
RPPFPPEVLAEALNT	PUSL1	86	Q8N0Z8
SPLPAPSPRISDILN	CAMK2B	441	Q13554
ESDLRFFLLPPPLPS	SERAC1	186	Q96JX3
DATLPDRPLSPPLTA	RAP1GAP2	36	Q684P5
RSPQPAERVDPALPL	SHD	221	Q96IW2
PSLEPNTSLEREPRP	SULT2B1	331	O00204
FIPPAPVLPSRDNEI	SPON2	251	Q9BUD6
FDPEFRLLEPVPSSP	PRR23A	216	A6NEV1
ETLRSNPPPSLAITP	NHS	1121	Q6T4R5
DLFTPLSRPPSPLSL	PLEKHA4	231	Q9H4M7
FLFPPAESLSPEEPR	ITPKB	56	P27987
PQEISPPPTANLDRS	PTK2	906	Q05397
GLDLSLSPRPDSPQP	PPP1R35	41	Q8TAP8
NFRSPPPTLSDPILR	PRDM16	931	Q9HAZ2
FTATPAEPRPLTSPL	PRRC2A	796	P48634
SFPLLDPSDAPFPSL	TANK	341	Q92844
SFSERELPQPPPLLS	SAMD11	286	Q96NU1
RRSLDEDEPPPSPLT	SAMD14	106	Q8IZD0
ELSPPQPLFRPRSEF	SETD1B	1661	Q9UPS6
RPSSPEPDDLFLPAR	OLIG2	11	Q13516
EAPTLSPPRDARPLT	PKN1	911	Q16512
EPPDSLAPPSSQAFL	TNS3	1006	Q68CZ2
EFLDLDNSPLSPPSP	NFATC2IP	191	Q8NCF5
DELLSDLTRTPPPPS	PHLDB2	541	Q86SQ0
TLQLRAEEPPTPALP	PLEKHO1	286	Q53GL0
PPSPRDEIFLTPNLS	ROBO4	936	Q8WZ75
APETPTQPPRFSELV	SNED1	1236	Q8TER0
PPQPDPVFLEALSSR	SERTAD3	126	Q9UJW9
PEFILTQSPPELAPA	ANHX	316	E9PGG2
ELPEFRPEEVLPSPT	CIC	1361	Q96RK0
PSLSLAPLSPRAPSE	CNKSR1	306	Q969H4
VTAFSQSPELPSPPR	XIRP2	291	A4UGR9
FSELPTPDTPVNPLD	URGCP	171	Q8TCY9
VPDLTPPNPARSLFA	PLK3	331	Q9H4B4
PPELSQRATLDTVPP	TICRR	1361	Q7Z2Z1
TPDSEPTPRPLALVF	SECTM1	211	Q8WVN6
SLRPLEEDTPSPLAP	TEP1	876	Q99973
PPPFTPSLLEQEVRA	MISP3	146	Q96FF7
LPIPSNLFVPTPDAE	SEC16A	2221	O15027
ELRLFPPDDSPLPVS	SRSF11	61	Q05519
LEPPTPTDLPSARAR	ST20-AS1	66	Q8NBB2
RIEDSTTASPPPLPL	TRABD2B	446	A6NFA1
PDTAPLPVPANIRFS	KIF20A	286	O95235
SPQSLPPASPLLEDR	TUT1	301	Q9H6E5
TPSSLLFDPETSPPL	TONSL	681	Q96HA7
VRDFPPPALSLELQP	TMEM121	271	Q9BTD3
SFSEAEPQLPPAPVR	TNS1	621	Q9HBL0
VASRPSPQPLAETPI	TNS1	676	Q9HBL0
AETPIPSLPEFPRAA	TNS1	686	Q9HBL0
PPPSSPAQEALDLLF	SNX15	176	Q9NRS6
PPEAPRPLFFLTLEA	PRRT4	336	C9JH25
DLPPASASRSVPIPL	SEMA6C	591	Q9H3T2
PFTPSPLPRLANQDS	SEZ6	101	Q53EL9
APETVPSAPENPRIF	ROS1	1036	P08922
LPRAAALERTEPSPP	TESK1	541	Q15569
FRRPEEAALSPLPPS	PRRG4	166	Q9BZD6
PEPSPAAPTLRSELE	PLEC	1191	Q15149
PAPSTRPLLSSEVPQ	TET3	316	O43151
LFAPSPSRDSLLPPT	TET3	666	O43151
FLRSPETPPVSPRES	IGSF9	966	Q9P2J2
RPLPTTVQAASPLPE	PRR33	81	A8MZF0
SSLPFLDPNARPLVP	CAD	146	P27708
SQFRERDIPSLPPLP	YLPM1	1321	P49750
PSLPPFLCPDLEEQS	NEURL3	91	Q96EH8
PLPREDPLTSPSRAQ	ZNF469	2101	Q96JG9
TPLTREDRPALQEPP	ZNF333	121	Q96JL9
PISRVDTFPQPLAAP	FTSJ1	296	Q9UET6
IPDRRPSLSPFAPDF	ZBTB7C	241	A1YPR0
PPPASSLQSPLNFLA	UBN1	726	Q9NPG3
TDLPEPPPSLTVQRD	ZDHHC8	696	Q9ULC8
LIPSRDSESPLPPLT	TXLNB	546	Q8N3L3
QPRATLAPSETPFVP	ABI3BP	421	Q7Z7G0
QEESELRSLPPPSPA	TUT4	336	Q5TAX3
EALELPEPRTPPLSS	ZFYVE26	1096	Q68DK2
PEPRTPPLSSLVEQA	ZFYVE26	1101	Q68DK2
PSLESEDFNIPPITP	TOX	61	O94900
VRPPPPLSSVFSEQA	ZNF318	1536	Q5VUA4
SPLDTPFLPASRDSP	WWC3	466	Q9ULE0
RPRELESPVPDSPQL	TEX12	16	Q9BXU0
EELFSVEPLPPRPSS	UBR5	1511	O95071
LPEEFLRPPSTSVAP	ZNF804A	791	Q7Z570
IPPRFSIAPSSLDPS	PLK1	321	P53350
FPPTSSLRQRPEPQV	TPP1	176	O14773
PRSREELPPNFPSEI	GUCY1A1	636	Q02108
ASRLFPPFEESPLSP	KMT2D	596	O14686
LDVRQLSAPPPEEPS	KMT2D	4901	O14686
PPLDRSLAPFDREPF	LCP2	241	Q13094
DLPPPAPTSRSLEDL	GRIN2D	1261	O15399