Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nitric-oxide synthase activity	NOS1 NOS2	6.10e-06	3	29	2	GO:0004517
GeneOntologyMolecularFunction	tetrahydrobiopterin binding	NOS1 NOS2	1.22e-05	4	29	2	GO:0034617
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	NOS1 NOS2 COQ6	2.62e-05	40	29	3	GO:0016709
GeneOntologyMolecularFunction	arginine binding	NOS1 NOS2	7.29e-05	9	29	2	GO:0034618
GeneOntologyMolecularFunction	FMN binding	NOS1 NOS2	2.41e-04	16	29	2	GO:0010181
GeneOntologyMolecularFunction	flavin adenine dinucleotide binding	NOS1 NOS2 COQ6	3.38e-04	94	29	3	GO:0050660
GeneOntologyMolecularFunction	carboxylic acid binding	SIGLEC12 NOS1 NOS2 SIGLEC9	3.76e-04	239	29	4	GO:0031406
GeneOntologyMolecularFunction	organic acid binding	SIGLEC12 NOS1 NOS2 SIGLEC9	4.73e-04	254	29	4	GO:0043177
GeneOntologyMolecularFunction	sialic acid binding	SIGLEC12 SIGLEC9	5.98e-04	25	29	2	GO:0033691
GeneOntologyMolecularFunction	monooxygenase activity	NOS1 NOS2 COQ6	6.10e-04	115	29	3	GO:0004497
GeneOntologyMolecularFunction	nuclear receptor binding	PRAMEF13 BAZ2A PRAMEF14	2.47e-03	187	29	3	GO:0016922
GeneOntologyMolecularFunction	serine-type endopeptidase activity	TPSD1 TPSAB1 TPSB2	2.58e-03	190	29	3	GO:0004252
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	NOS1 NOS2 COQ6	2.74e-03	194	29	3	GO:0016705
GeneOntologyMolecularFunction	nuclear retinoic acid receptor binding	PRAMEF13 PRAMEF14	2.88e-03	55	29	2	GO:0042974
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	TCERG1 PRAMEF13 BAZ2A PRAMEF14	2.94e-03	417	29	4	GO:0061629
GeneOntologyMolecularFunction	serine-type peptidase activity	TPSD1 TPSAB1 TPSB2	3.29e-03	207	29	3	GO:0008236
GeneOntologyMolecularFunction	serine hydrolase activity	TPSD1 TPSAB1 TPSB2	3.52e-03	212	29	3	GO:0017171
GeneOntologyMolecularFunction	NADP binding	NOS1 NOS2	3.65e-03	62	29	2	GO:0050661
GeneOntologyMolecularFunction	amino acid binding	NOS1 NOS2	5.02e-03	73	29	2	GO:0016597
GeneOntologyMolecularFunction	ubiquitin-like ligase-substrate adaptor activity	PRAMEF13 PRAMEF14	6.29e-03	82	29	2	GO:1990756
GeneOntologyBiologicalProcess	negative regulation of phagocytosis, engulfment	SIGLEC12 SIGLEC9	1.77e-05	5	28	2	GO:0060101
GeneOntologyBiologicalProcess	negative regulation of membrane invagination	SIGLEC12 SIGLEC9	2.66e-05	6	28	2	GO:1905154
GeneOntologyBiologicalProcess	positive regulation of guanylate cyclase activity	NOS1 NOS2	2.66e-05	6	28	2	GO:0031284
GeneOntologyBiologicalProcess	regulation of guanylate cyclase activity	NOS1 NOS2	4.95e-05	8	28	2	GO:0031282
GeneOntologyBiologicalProcess	arginine catabolic process	NOS1 NOS2	7.94e-05	10	28	2	GO:0006527
GeneOntologyBiologicalProcess	peptidyl-cysteine S-nitrosylation	NOS1 NOS2	2.39e-04	17	28	2	GO:0018119
GeneOntologyBiologicalProcess	negative regulation of endocytosis	SIGLEC12 PACSIN1 SIGLEC9	2.59e-04	92	28	3	GO:0045806
GeneOntologyBiologicalProcess	protein nitrosylation	NOS1 NOS2	2.68e-04	18	28	2	GO:0017014
GeneOntologyBiologicalProcess	arginine metabolic process	NOS1 NOS2	3.33e-04	20	28	2	GO:0006525
GeneOntologyBiologicalProcess	regulation of phagocytosis, engulfment	SIGLEC12 SIGLEC9	4.81e-04	24	28	2	GO:0060099
GeneOntologyBiologicalProcess	positive regulation of purine nucleotide biosynthetic process	NOS1 NOS2	5.23e-04	25	28	2	GO:1900373
GeneOntologyBiologicalProcess	regulation of membrane invagination	SIGLEC12 SIGLEC9	5.23e-04	25	28	2	GO:1905153
GeneOntologyBiologicalProcess	positive regulation of nucleotide biosynthetic process	NOS1 NOS2	5.23e-04	25	28	2	GO:0030810
GeneOntologyBiologicalProcess	glutamine family amino acid catabolic process	NOS1 NOS2	6.11e-04	27	28	2	GO:0009065
GeneOntologyBiologicalProcess	negative regulation of phagocytosis	SIGLEC12 SIGLEC9	9.14e-04	33	28	2	GO:0050765
GeneOntologyCellularComponent	mast cell granule	TPSD1 TPSAB1	5.18e-05	8	29	2	GO:0042629
HumanPheno	Prominent crus of helix	NSD2 DHX30	3.39e-05	7	7	2	HP:0009899
MousePheno	delayed peripheral nervous system regeneration	NOS1 NOS2	1.84e-05	4	25	2	MP:0031330
MousePheno	decreased susceptibility to induced choroidal neovascularization	NOS1 NOS2	1.37e-04	10	25	2	MP:0003434
MousePheno	abnormal mast cell differentiation	TPSD1 TPSAB1	1.37e-04	10	25	2	MP:0005462
MousePheno	abnormal peripheral nervous system regeneration	NOS1 NOS2	1.67e-04	11	25	2	MP:0004220
MousePheno	abnormal neutrophil physiology	SIGLEC12 TPSAB1 NOS1 SIGLEC9	1.95e-04	165	25	4	MP:0002463
MousePheno	increased urine pH	NOS1 NOS2	2.37e-04	13	25	2	MP:0009349
Domain	-	NOS1 NOS2	6.03e-06	3	27	2	3.90.340.10
Domain	NOS_N	NOS1 NOS2	6.03e-06	3	27	2	IPR004030
Domain	NOS	NOS1 NOS2	6.03e-06	3	27	2	PS60001
Domain	NO_synthase	NOS1 NOS2	6.03e-06	3	27	2	PF02898
Domain	NOS_euk	NOS1 NOS2	6.03e-06	3	27	2	IPR012144
Domain	-	NOS1 NOS2	3.01e-05	6	27	2	1.20.990.10
Domain	NADPH_Cyt_P450_Rdtase_dom3	NOS1 NOS2	3.01e-05	6	27	2	IPR023173
Domain	FAD_binding_1	NOS1 NOS2	3.01e-05	6	27	2	PF00667
Domain	FAD-binding_1	NOS1 NOS2	3.01e-05	6	27	2	IPR003097
Domain	Flavdoxin-like	NOS1 NOS2	5.61e-05	8	27	2	IPR001094
Domain	FLAVODOXIN_LIKE	NOS1 NOS2	5.61e-05	8	27	2	PS50902
Domain	Flavodoxin_1	NOS1 NOS2	5.61e-05	8	27	2	PF00258
Domain	Flavodoxin/NO_synth	NOS1 NOS2	5.61e-05	8	27	2	IPR008254
Domain	Flavoprotein-like_dom	NOS1 NOS2	8.99e-05	10	27	2	IPR029039
Domain	Flavoprot_Pyr_Nucl_cyt_Rdtase	NOS1 NOS2	8.99e-05	10	27	2	IPR001709
Domain	-	NOS1 NOS2	8.99e-05	10	27	2	3.40.50.360
Domain	OxRdtase_FAD/NAD-bd	NOS1 NOS2	1.32e-04	12	27	2	IPR001433
Domain	NAD_binding_1	NOS1 NOS2	1.32e-04	12	27	2	PF00175
Domain	TRYPSIN_SER	TPSD1 TPSAB1 TPSB2	2.91e-04	90	27	3	IPR033116
Domain	Fd_Rdtase_FAD-bd	NOS1 NOS2	3.39e-04	19	27	2	IPR017927
Domain	FAD_FR	NOS1 NOS2	3.39e-04	19	27	2	PS51384
Domain	Riboflavin_synthase-like_b-brl	NOS1 NOS2	3.39e-04	19	27	2	IPR017938
Domain	TRYPSIN_HIS	TPSD1 TPSAB1 TPSB2	4.33e-04	103	27	3	IPR018114
Domain	TRYPSIN_SER	TPSD1 TPSAB1 TPSB2	4.71e-04	106	27	3	PS00135
Domain	TRYPSIN_HIS	TPSD1 TPSAB1 TPSB2	4.84e-04	107	27	3	PS00134
Domain	Peptidase_S1A	TPSD1 TPSAB1 TPSB2	5.67e-04	113	27	3	IPR001314
Domain	TRYPSIN_DOM	TPSD1 TPSAB1 TPSB2	5.97e-04	115	27	3	PS50240
Domain	Tryp_SPc	TPSD1 TPSAB1 TPSB2	6.28e-04	117	27	3	SM00020
Domain	Trypsin	TPSD1 TPSAB1 TPSB2	6.93e-04	121	27	3	PF00089
Domain	Trypsin_dom	TPSD1 TPSAB1 TPSB2	6.93e-04	121	27	3	IPR001254
Domain	Peptidase_S1_PA	TPSD1 TPSAB1 TPSB2	7.26e-04	123	27	3	IPR009003
Domain	C2-set_2	SIGLEC12 SIGLEC9	1.59e-03	41	27	2	PF08205
Domain	CD80_C2-set	SIGLEC12 SIGLEC9	1.59e-03	41	27	2	IPR013162
Domain	V-set	SIGLEC12 LY6G6F SIGLEC9	2.31e-03	184	27	3	PF07686
Domain	Ig_V-set	SIGLEC12 LY6G6F SIGLEC9	2.89e-03	199	27	3	IPR013106
Domain	PHD	BAZ2A NSD2	5.23e-03	75	27	2	PF00628
Domain	Znf_PHD-finger	BAZ2A NSD2	5.79e-03	79	27	2	IPR019787
Domain	PHD	BAZ2A NSD2	7.29e-03	89	27	2	SM00249
Domain	Znf_PHD	BAZ2A NSD2	7.61e-03	91	27	2	IPR001965
Domain	ZF_PHD_2	BAZ2A NSD2	8.27e-03	95	27	2	PS50016
Domain	ZF_PHD_1	BAZ2A NSD2	8.44e-03	96	27	2	PS01359
Domain	-	SIGLEC12 LY6G6F SIGLEC9 INSRR	1.44e-02	663	27	4	2.60.40.10
Pathway	WP_EFFECTS_OF_NITRIC_OXIDE	NOS1 NOS2	4.80e-05	8	19	2	M39677
Pathway	WP_NITRIC_OXIDE_METABOLISM_IN_CYSTIC_FIBROSIS	NOS1 NOS2	1.33e-04	13	19	2	M39894
Pathway	REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE	NOS1 NOS2	1.33e-04	13	19	2	MM15015
Pathway	REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE	NOS1 NOS2	3.91e-04	22	19	2	M915
Pathway	WP_SILDENAFIL_TREATMENT	NOS1 NOS2	4.28e-04	23	19	2	M46455
Pathway	WP_UREA_CYCLE_AND_ASSOCIATED_PATHWAYS	NOS1 NOS2	4.67e-04	24	19	2	M39850
Pathway	REACTOME_ROS_AND_RNS_PRODUCTION_IN_PHAGOCYTES	NOS1 NOS2	1.06e-03	36	19	2	M26923
Pathway	REACTOME_ROS_AND_RNS_PRODUCTION_IN_PHAGOCYTES	NOS1 NOS2	1.18e-03	38	19	2	MM14519
Pathway	WP_MICROGLIA_PATHOGEN_PHAGOCYTOSIS_PATHWAY	SIGLEC12 SIGLEC9	1.72e-03	46	19	2	MM15837
Pathway	WP_NOCGMPPKG_MEDIATED_NEUROPROTECTION	NOS1 NOS2	1.79e-03	47	19	2	M39531
Pubmed	Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3.	TPSD1 TPSAB1 TPSB2	5.21e-10	3	29	3	9920877
Pubmed	Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations.	TPSD1 TPSAB1 TPSB2	5.21e-10	3	29	3	19748655
Pubmed	New developments in the genetics and activation of mast cell proteases.	TPSD1 TPSAB1 TPSB2	1.04e-08	6	29	3	12217407
Pubmed	Family-based association study between NOS-I and -IIA polymorphisms and autism spectrum disorders in Korean trios.	NOS1 NOS2	6.71e-07	2	29	2	18563708
Pubmed	Essential role for mast cell tryptase in acute experimental colitis.	TPSD1 TPSAB1	6.71e-07	2	29	2	21173247
Pubmed	Mast Cell Protease 7 Promotes Angiogenesis by Degradation of Integrin Subunits.	TPSD1 TPSAB1	6.71e-07	2	29	2	31013764
Pubmed	Role of different nitric oxide synthase isoforms in a murine model of acute lung injury and sepsis.	NOS1 NOS2	6.71e-07	2	29	2	20655878
Pubmed	Human beta-tryptase is a ring-like tetramer with active sites facing a central pore.	TPSAB1 TPSB2	6.71e-07	2	29	2	9521329
Pubmed	The spinal cord expression of neuronal and inducible nitric oxide synthases and their contribution in the maintenance of neuropathic pain in mice.	NOS1 NOS2	6.71e-07	2	29	2	21179208
Pubmed	The structure of the human betaII-tryptase tetramer: fo(u)r better or worse.	TPSAB1 TPSB2	6.71e-07	2	29	2	10500112
Pubmed	The mouse mast cell-restricted tetramer-forming tryptases mouse mast cell protease 6 and mouse mast cell protease 7 are critical mediators in inflammatory arthritis.	TPSD1 TPSAB1	6.71e-07	2	29	2	18668540
Pubmed	Spontaneous sleep in mice with targeted disruptions of neuronal or inducible nitric oxide synthase genes.	NOS1 NOS2	6.71e-07	2	29	2	12738065
Pubmed	Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family.	TPSAB1 TPSB2	6.71e-07	2	29	2	2187193
Pubmed	Characterization of a tryptase mRNA expressed in the human basophil cell line KU812.	TPSAB1 TPSB2	6.71e-07	2	29	2	8434231
Pubmed	Delta tryptase is expressed in multiple human tissues, and a recombinant form has proteolytic activity.	TPSD1 TPSAB1	6.71e-07	2	29	2	12391231
Pubmed	Natural disruption of the mouse mast cell protease 7 gene in the C57BL/6 mouse.	TPSD1 TPSAB1	6.71e-07	2	29	2	8576265
Pubmed	Deficiency of iNOS does not attenuate severe congestive heart failure in mice.	NOS1 NOS2	6.71e-07	2	29	2	15319210
Pubmed	Roles of iNOS and nNOS in sepsis-induced pulmonary apoptosis.	NOS1 NOS2	6.71e-07	2	29	2	14660484
Pubmed	Role of inducible or neuronal nitric oxide synthase in neurogenesis of the dentate gyrus in aged mice.	NOS1 NOS2	6.71e-07	2	29	2	21082337
Pubmed	Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.	NOS1 NOS2	6.71e-07	2	29	2	7682706
Pubmed	Pyroptotic and apoptotic cell death in iNOS and nNOS overexpressing K562 cells: A mechanistic insight.	NOS1 NOS2	6.71e-07	2	29	2	31881190
Pubmed	Inducible nitric oxide synthase is involved in acid-induced gastric hyperemia in rats and mice.	NOS1 NOS2	6.71e-07	2	29	2	12646421
Pubmed	Increase in TPSB2 and TPSD1 Expression in Synovium of Hip Osteoarthritis Patients Who Are Overweight.	TPSD1 TPSB2	6.71e-07	2	29	2	37511292
Pubmed	Structural requirements and mechanism for heparin-dependent activation and tetramerization of human betaI- and betaII-tryptase.	TPSAB1 TPSB2	6.71e-07	2	29	2	15567416
Pubmed	The role of nitric oxide synthases in the sleep responses to tumor necrosis factor-alpha.	NOS1 NOS2	6.71e-07	2	29	2	15157956
Pubmed	Effects of ethanol on neutrophil recruitment and lung host defense in nitric oxide synthase I and nitric oxide synthase II knockout mice.	NOS1 NOS2	6.71e-07	2	29	2	10512307
Pubmed	Association between inducible and neuronal nitric oxide synthase polymorphisms and recurrent depressive disorder.	NOS1 NOS2	6.71e-07	2	29	2	20888049
Pubmed	Alternate mRNA splicing in multiple human tryptase genes is predicted to regulate tetramer formation.	TPSD1 TPSAB1	6.71e-07	2	29	2	18854315
Pubmed	Role of Nitric Oxide in Stress-Induced Anxiety: From Pathophysiology to Therapeutic Target.	NOS1 NOS2	6.71e-07	2	29	2	28061969
Pubmed	Mechanistic studies on the intramolecular one-electron transfer between the two flavins in the human neuronal nitric-oxide synthase and inducible nitric-oxide synthase flavin domains.	NOS1 NOS2	6.71e-07	2	29	2	12777376
Pubmed	[Expression of cell adhesion molecule and nitric oxide synthase in nasal mucosa in allergic rhinitis].	NOS1 NOS2	6.71e-07	2	29	2	16780147
Pubmed	Human tryptases alpha and beta/II are functionally distinct due, in part, to a single amino acid difference in one of the surface loops that forms the substrate-binding cleft.	TPSAB1 TPSB2	6.71e-07	2	29	2	10391906
Pubmed	The human mast cell tryptase tetramer: a fascinating riddle solved by structure.	TPSAB1 TPSB2	6.71e-07	2	29	2	10708850
Pubmed	Cloning and characterization of a second complementary DNA for human tryptase.	TPSAB1 TPSB2	6.71e-07	2	29	2	2203827
Pubmed	Tryptase haplotype in mastocytosis: relationship to disease variant and diagnostic utility of total tryptase levels.	TPSAB1 TPSB2	6.71e-07	2	29	2	17449330
Pubmed	Inducible-NOS but not neuronal-NOS participate in the acute effect of TNF-alpha on hypothalamic insulin-dependent inhibition of food intake.	NOS1 NOS2	6.71e-07	2	29	2	16876161
Pubmed	Chronic alcohol consumption induces an overproduction of NO by nNOS- and iNOS-expressing myenteric neurons in the murine small intestine.	NOS1 NOS2	6.71e-07	2	29	2	21470341
Pubmed	Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease.	NOS1 NOS2	6.71e-07	2	29	2	10581083
Pubmed	Role of nitric oxide synthase in the development of bone cancer pain and effect of L-NMMA.	NOS1 NOS2	6.71e-07	2	29	2	26648027
Pubmed	Nitric oxide synthases: roles, tolls, and controls.	NOS1 NOS2	6.71e-07	2	29	2	7522969
Pubmed	Functional variants in NOS1 and NOS2A are not associated with progressive hearing loss in Ménière's disease in a European Caucasian population.	NOS1 NOS2	6.71e-07	2	29	2	21612410
Pubmed	The tryptase, mouse mast cell protease 7, exhibits anticoagulant activity in vivo and in vitro due to its ability to degrade fibrinogen in the presence of the diverse array of protease inhibitors in plasma.	TPSD1 TPSAB1	6.71e-07	2	29	2	9395536
Pubmed	Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia.	TPSAB1 TPSB2	6.71e-07	2	29	2	31337736
Pubmed	Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.	NOS1 NOS2	6.71e-07	2	29	2	1372907
Pubmed	Genetic deficiency of human mast cell alpha-tryptase.	TPSD1 TPSAB1	6.71e-07	2	29	2	12100045
Pubmed	Contribution of inducible and neuronal nitric oxide synthases to mitochondrial damage and melatonin rescue in LPS-treated mice.	NOS1 NOS2	6.71e-07	2	29	2	28110436
Pubmed	Polymorphisms of the neuronal and inducible nitric oxide synthase genes and the risk of cutaneous melanoma: a case-control study.	NOS1 NOS2	6.71e-07	2	29	2	17328085
Pubmed	Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases.	NOS1 NOS2	6.71e-07	2	29	2	28800639
Pubmed	Association between Parkinson's disease and polymorphisms in the nNOS and iNOS genes in a community-based case-control study.	NOS1 NOS2	6.71e-07	2	29	2	12490535
Pubmed	Identification and molecular cloning of a novel mouse mucosal mast cell serine protease.	TPSD1 TPSAB1	6.71e-07	2	29	2	1688433
Pubmed	Increased nitric oxide caused by the ketogenic diet reduces the onset time of kainic acid-induced seizures in ICR mice.	NOS1 NOS2	6.71e-07	2	29	2	16460714
Pubmed	Characterization of two highly polymorphic human tryptase loci and comparison with a newly discovered monkey tryptase ortholog.	TPSAB1 TPSB2	6.71e-07	2	29	2	10898108
Pubmed	Lack of expression of the tryptase mouse mast cell protease 7 in mast cells of the C57BL/6J mouse.	TPSD1 TPSAB1	6.71e-07	2	29	2	8077672
Pubmed	Isolation, characterization, and transcription of the gene encoding mouse mast cell protease 7.	TPSD1 TPSAB1	6.71e-07	2	29	2	1454796
Pubmed	Influenza virus-induced sleep responses in mice with targeted disruptions in neuronal or inducible nitric oxide synthases.	NOS1 NOS2	6.71e-07	2	29	2	15220315
Pubmed	Transcriptional regulation of mouse mast cell protease-7 by TGF-beta.	TPSD1 TPSAB1	6.71e-07	2	29	2	16730810
Pubmed	Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme.	NOS1 NOS2	6.71e-07	2	29	2	1379716
Pubmed	A conserved Val to Ile switch near the heme pocket of animal and bacterial nitric-oxide synthases helps determine their distinct catalytic profiles.	NOS1 NOS2	6.71e-07	2	29	2	14976216
Pubmed	Intra- and inter-molecular effects of a conserved arginine residue of neuronal and inducible nitric oxide synthases on FMN and calmodulin binding.	NOS1 NOS2	6.71e-07	2	29	2	23507581
Pubmed	Nitric oxide mediates selective degeneration of hypothalamic orexin neurons through dysfunction of protein disulfide isomerase.	NOS1 NOS2	6.71e-07	2	29	2	23904594
Pubmed	Fate of two mast cell tryptases in V3 mastocytosis and normal BALB/c mice undergoing passive systemic anaphylaxis: prolonged retention of exocytosed mMCP-6 in connective tissues, and rapid accumulation of enzymatically active mMCP-7 in the blood.	TPSD1 TPSAB1	6.71e-07	2	29	2	9064323
Pubmed	2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors.	NOS1 NOS2	2.01e-06	3	29	2	35772285
Pubmed	Human immunodeficiency virus-1-infected macrophages induce inducible nitric oxide synthase and nitric oxide (NO) production in astrocytes: astrocytic NO as a possible mediator of neural damage in acquired immunodeficiency syndrome.	NOS1 NOS2	2.01e-06	3	29	2	10068656
Pubmed	Molecular architecture of mammalian nitric oxide synthases.	NOS1 NOS2	2.01e-06	3	29	2	25125509
Pubmed	Crucial role for neuronal nitric oxide synthase in early microcirculatory derangement and recipient survival following murine pancreas transplantation.	NOS1 NOS2	2.01e-06	3	29	2	25389974
Pubmed	The gastric mucus layers: constituents and regulation of accumulation.	NOS1 NOS2	2.01e-06	3	29	2	18719000
Pubmed	Nitric oxide synthase isoforms and NF-kappaB activity in normal and osteoarthritic human chondrocytes: regulation by inducible nitric oxide.	NOS1 NOS2	2.01e-06	3	29	2	18675932
Pubmed	Relative contributions of endothelial, inducible, and neuronal NOS to tone in the murine pulmonary circulation.	NOS1 NOS2	2.01e-06	3	29	2	10484454
Pubmed	Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical period.	NOS1 NOS2	2.01e-06	3	29	2	24305053
Pubmed	Lessons learned from nitric oxide synthase knockout animals.	NOS1 NOS2	2.01e-06	3	29	2	10709868
Pubmed	Reductase domain cysteines 1048 and 1114 are critical for catalytic activity of human endothelial cell nitric oxide synthase as probed by site-directed mutagenesis.	NOS1 NOS2	2.01e-06	3	29	2	8806629
Pubmed	Crucial roles of nitric oxide synthases in β-adrenoceptor-mediated bladder relaxation in mice.	NOS1 NOS2	2.01e-06	3	29	2	27784691
Pubmed	Differential regulation of neuronal and inducible nitric oxide synthase (NOS) in the spinal cord of mutant SOD1 (G93A) ALS mice.	NOS1 NOS2	2.01e-06	3	29	2	19580782
Pubmed	Increase in Red Blood Cell-Nitric Oxide Synthase Dependent Nitric Oxide Production during Red Blood Cell Aging in Health and Disease: A Study on Age Dependent Changes of Rheologic and Enzymatic Properties in Red Blood Cells.	NOS1 NOS2	2.01e-06	3	29	2	25902315
Pubmed	Role of NO synthase in the development of Trypanosoma cruzi-induced cardiomyopathy in mice.	NOS1 NOS2	2.01e-06	3	29	2	19407124
Pubmed	Myeloid cell-derived inducible nitric oxide synthase suppresses M1 macrophage polarization.	NOS1 NOS2	2.01e-06	3	29	2	25813085
Pubmed	Nitric oxide synthase gene knockout mice do not become hypertensive during pregnancy.	NOS1 NOS2	2.01e-06	3	29	2	11717657
Pubmed	Differential expression of nitric oxide synthases (NOS 1-3) in human skeletal muscle following exercise countermeasure during 12 weeks of bed rest.	NOS1 NOS2	2.01e-06	3	29	2	15180967
Pubmed	Alterations in nitric oxide synthase isoforms in acute lower limb ischemia and reperfusion.	NOS1 NOS2	2.01e-06	3	29	2	18024942
Pubmed	Limb reduction defects in endothelial nitric oxide synthase-deficient mice.	NOS1 NOS2	2.01e-06	3	29	2	9843834
Pubmed	Protective roles of nitric oxide and testosterone in endotoxemia: evidence from NOS-2-deficient mice.	NOS1 NOS2	2.01e-06	3	29	2	9843821
Pubmed	mRNA expressions of inducible nitric oxide synthase, endothelial nitric oxide synthase, and neuronal nitric oxide synthase genes in meningitis patients.	NOS1 NOS2	2.01e-06	3	29	2	21204701
Pubmed	Estrogen induces nitric oxide production via activation of constitutive nitric oxide synthases in human neuroblastoma cells.	NOS1 NOS2	2.01e-06	3	29	2	15242984
Pubmed	Nitric oxide synthase in the vestibulocochlear system of mice.	NOS1 NOS2	2.01e-06	3	29	2	9824677
Pubmed	Secretagogue-stimulated pancreatic secretion is differentially regulated by constitutive NOS isoforms in mice.	NOS1 NOS2	2.01e-06	3	29	2	14551061
Pubmed	Spontaneous myocardial infarction in mice lacking all nitric oxide synthase isoforms.	NOS1 NOS2	2.01e-06	3	29	2	18413498
Pubmed	Nitric oxide synthases and heart failure - lessons from genetically manipulated mice.	NOS1 NOS2	2.01e-06	3	29	2	23774658
Pubmed	Human immunodeficiency virus infection, inducible nitric oxide synthase expression, and microglial activation: pathogenetic relationship to the acquired immunodeficiency syndrome dementia complex.	NOS1 NOS2	2.01e-06	3	29	2	10443886
Pubmed	Mechanisms and structural determinants of HIV-1 coat protein, gp41-induced neurotoxicity.	NOS1 NOS2	2.01e-06	3	29	2	9870939
Pubmed	Severe dyslipidaemia, atherosclerosis, and sudden cardiac death in mice lacking all NO synthases fed a high-fat diet.	NOS1 NOS2	2.01e-06	3	29	2	20304785
Pubmed	Paradoxical roles of different nitric oxide synthase isoforms in colonic injury.	NOS1 NOS2	2.01e-06	3	29	2	14665440
Pubmed	Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease.	NOS1 NOS2	2.01e-06	3	29	2	24192154
Pubmed	High-protein-induced glomerular hyperfiltration is independent of the tubuloglomerular feedback mechanism and nitric oxide synthases.	NOS1 NOS2	2.01e-06	3	29	2	20739607
Pubmed	Expression of nitric oxide synthase isoforms in human pregnant myometrium at term.	NOS1 NOS2	2.01e-06	3	29	2	12445599
Pubmed	Biochemistry of soluble guanylate cyclase.	NOS1 NOS2	2.01e-06	3	29	2	19089323
Pubmed	Exhaled nitric oxide production by nitric oxide synthase-deficient mice.	NOS1 NOS2	2.01e-06	3	29	2	11029328
Pubmed	Cardiovascular and renal control in NOS-deficient mouse models.	NOS1 NOS2	2.01e-06	3	29	2	12571071
Pubmed	Decreased viability of nitric oxide synthase double knockout mice.	NOS1 NOS2	2.01e-06	3	29	2	12704728
Pubmed	The expression pattern of three mast cell specific proteases during mouse development.	TPSD1 TPSAB1	2.01e-06	3	29	2	16777228
Pubmed	Deletion of neuronal NOS prevents impaired vasodilation in septic mouse skeletal muscle.	NOS1 NOS2	2.01e-06	3	29	2	17258180
Cytoband	16p13.3	TPSD1 TPSAB1 TPSB2	4.89e-04	244	29	3	16p13.3
Cytoband	1p36.21	PRAMEF13 PRAMEF14	7.35e-04	63	29	2	1p36.21
Cytoband	Ensembl 112 genes in cytogenetic band chr16p13	TPSD1 TPSAB1 TPSB2	2.42e-03	426	29	3	chr16p13
GeneFamily	PRAME family	PRAMEF13 PRAMEF14	2.27e-04	24	17	2	686
GeneFamily	CD molecules\|C2-set domain containing\|Sialic acid binding Ig like lectins	SIGLEC12 SIGLEC9	3.10e-04	28	17	2	745
GeneFamily	Adenosine receptors\|V-set domain containing	SIGLEC12 LY6G6F SIGLEC9	4.46e-04	163	17	3	590
GeneFamily	PHD finger proteins	BAZ2A NSD2	3.17e-03	90	17	2	88
CoexpressionAtlas	geo_heart_top-relative-expression-ranked_500_k-means-cluster#5	TPSAB1 TPSB2	4.34e-05	8	27	2	geo_heart_500_K5
ToppCell	Parenchymal-10x5prime-Immune_Myeloid-Myeloid\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TPSD1 TPSAB1 LY6G6F TPSB2	9.81e-07	117	29	4	f0c738b6b850733f9af68704172554177a1c1198
ToppCell	Parenchymal-10x5prime-Immune_Myeloid-Myeloid-Megakaryocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TPSD1 TPSAB1 LY6G6F TPSB2	9.81e-07	117	29	4	b5cb9d69ddd42331134f7e4bd51bd1c31030893c
ToppCell	Children_(3_yrs)-Immune-mast_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TPSD1 TPSAB1 NKAIN1 TPSB2	2.71e-06	151	29	4	bbf735c6433c3fc2feedb24ed6f48c51d545fb60
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic-Mast_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SIGLEC12 TPSD1 TPSAB1 TPSB2	4.04e-06	167	29	4	a813b95c2fafb638b249bc4fa4f708c6f39ad444
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Granulocytic\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TPSD1 TPSAB1 SIGLEC9 TPSB2	4.65e-06	173	29	4	9eaec30f9a3655b53ece1b66848201a7f85bbdf5
ToppCell	LV-17._Lymphocyte\|World / Chamber and Cluster_Paper	TPSD1 TPSAB1 ZNF831 TPSB2	4.65e-06	173	29	4	212f013ff761cbab24a537071739867c08c402a4
ToppCell	10x5'v1-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast-basophil\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	TPSD1 TPSAB1 TPSB2 RUSC2	4.87e-06	175	29	4	ba1befc4e5f0167452f9ceace39377d16136dfa9
ToppCell	LV-17._Lymphocyte\|LV / Chamber and Cluster_Paper	TPSD1 TPSAB1 ZNF831 TPSB2	5.56e-06	181	29	4	81fafa69c8c240250a667a5f3b321e8be1b9a288
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-Mast_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TPSD1 TPSAB1 TPSB2 KCNH3	5.94e-06	184	29	4	16ba6822570b1017b8f24d9439b4fbdaaeecf7aa
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TPSD1 TPSAB1 ZNF831 TPSB2	6.88e-06	191	29	4	468b5149d1533f03521844d3cce8633d44eb6ed4
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-Myeloid\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TPSD1 TPSAB1 SIGLEC9 TPSB2	8.09e-06	199	29	4	a4785c1921a3de18a9190e4d674ede6a90f80004
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Myeloid-Megakaryocyte\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TPSD1 TPSAB1 TPSB2 RUSC2	8.09e-06	199	29	4	6e7f7214317f2af2ba8523df9896f54b7294d58a
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Myeloid\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TPSD1 TPSAB1 TPSB2 RUSC2	8.09e-06	199	29	4	5f499595597c10857bba8272f62afe4d32d733ac
ToppCell	Entopeduncular-Macroglia-OLIGODENDROCYTE-O1-Trf\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	NKAIN1 OPN4 SSPOP	1.64e-05	76	29	3	efbbbf91bca35720d8ecddb076f2c9f4de25e44d
ToppCell	Entopeduncular-Macroglia-OLIGODENDROCYTE-O1\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	NKAIN1 OPN4 SSPOP	1.64e-05	76	29	3	254d18bece2676faa4bbeb8d48b1d327ab3c2215
ToppCell	Hippocampus-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Ndrg2_(MyelinProcesses)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CCDC187 LY6G6F SSPOP	1.71e-05	77	29	3	4720aa099bd00d05b721634eedc9a08b0213ee67
ToppCell	Hippocampus-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Ndrg2_(MyelinProcesses)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CCDC187 LY6G6F SSPOP	1.71e-05	77	29	3	25a8dd4cdba4d96d6b0c35fa6310bfff6ce64265
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf-Oligodendrocyte.Trf.Ctps_(Ctps)\|Striatum / BrainAtlas - Mouse McCarroll V32	NKAIN1 OPN4 SSPOP	1.84e-05	79	29	3	239d34f40c3a96186231f3aabd41c4988af3f372
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf\|Striatum / BrainAtlas - Mouse McCarroll V32	NKAIN1 OPN4 SSPOP	1.84e-05	79	29	3	a60fcbb278ba629af922c53faf58e4d96c537b15
ToppCell	Posterior_cortex-Macroglia-OLIGODENDROCYTE-O2-Tfr\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CCDC187 LY6G6F NKAIN1	3.41e-05	97	29	3	4b74b3c5b9590a8215b7370b37e9723e9f040b9c
ToppCell	Posterior_cortex-Macroglia-OLIGODENDROCYTE-O2\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CCDC187 LY6G6F NKAIN1	3.41e-05	97	29	3	7b17dc28454949a23701ab127300a29a8899d7d6
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Parm1\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	TPSAB1 ZNF831 TPSB2	5.10e-05	111	29	3	1847dde68d349114286bc3317be6339666df4aa2
ToppCell	Thalamus-Macroglia-OLIGODENDROCYTE-O1-Trf\|Thalamus / BrainAtlas - Mouse McCarroll V32	CCDC187 LY6G6F NKAIN1	5.23e-05	112	29	3	cb351e57c99aaaf9ae6c7ff7e8ce5375552b1639
ToppCell	Thalamus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Il33_(Il33)\|Thalamus / BrainAtlas - Mouse McCarroll V32	CCDC187 LY6G6F NKAIN1	5.23e-05	112	29	3	999b5eeed4305e1a1385aadbaf017b64f21c1ee0
ToppCell	Thalamus-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendrocyte.Trf.Il33_(Il33)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	CCDC187 LY6G6F NKAIN1	5.23e-05	112	29	3	004cd69b66c3b26b9a61f03279b48230da351574
ToppCell	Thalamus-Macroglia-OLIGODENDROCYTE-O1\|Thalamus / BrainAtlas - Mouse McCarroll V32	CCDC187 LY6G6F NKAIN1	5.23e-05	112	29	3	502e3f356f6e1c959bff0a39c98f33f863ce8265
ToppCell	Globus_pallidus-Macroglia-OLIGODENDROCYTE-O1\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	LY6G6F NKAIN1 SSPOP	6.11e-05	118	29	3	d0dd5c882cd9e0a5eb0cb08e47877292126bd4ae
ToppCell	Globus_pallidus-Macroglia-OLIGODENDROCYTE-O1-Trf\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	LY6G6F NKAIN1 SSPOP	6.11e-05	118	29	3	4283699cb3ca7a112faa07727dfdc0b0a67fb779
ToppCell	Globus_pallidus-Macroglia-OLIGODENDROCYTE-O2\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	LY6G6F NKAIN1 SSPOP	6.75e-05	122	29	3	d4152c45dfbb979ddf8380b4896db753a79cad9e
ToppCell	Frontal_cortex-Macroglia-OLIGODENDROCYTE-O2\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	LY6G6F NKAIN1 SSPOP	6.75e-05	122	29	3	2880f25d10a7765e55a2aa20c7a6ef74cea19c4d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic-Mast_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TPSD1 TPSAB1 TPSB2	6.75e-05	122	29	3	032b5da8befcb1a159245f8d0c67f91795883ee0
ToppCell	Frontal_cortex-Macroglia-OLIGODENDROCYTE-O2-Tnr\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	LY6G6F NKAIN1 SSPOP	6.75e-05	122	29	3	cffd7730bda90828efc0def452cabb44cf93ab48
ToppCell	Globus_pallidus-Macroglia-OLIGODENDROCYTE-O2-Trf\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	LY6G6F NKAIN1 SSPOP	6.75e-05	122	29	3	40f983623c990203df4ba997e296231489d51012
ToppCell	Frontal_cortex-Macroglia-OLIGODENDROCYTE\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	LY6G6F NKAIN1 SSPOP	6.75e-05	122	29	3	ecd0e54dd829201290212ea2ff7c8e7eec19c0e9
ToppCell	Posterior_cortex-Macroglia-OLIGODENDROCYTE\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	LY6G6F NKAIN1 SSPOP	7.09e-05	124	29	3	9f169fa17be1842a6bd83778ff30465a740edd5f
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_granulocytic-basophil\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TPSD1 TPSAB1 TPSB2	7.26e-05	125	29	3	dec39707624529689f68dd46f910a71db5e91ab2
ToppCell	Globus_pallidus-Macroglia-OLIGODENDROCYTE\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	LY6G6F NKAIN1 SSPOP	7.97e-05	129	29	3	98a5f24de72d2ae6a57787226b2e523ddd13b2c5
ToppCell	Hippocampus-Macroglia-OLIGODENDROCYTE\|Hippocampus / BrainAtlas - Mouse McCarroll V32	LY6G6F NKAIN1 SSPOP	9.52e-05	137	29	3	5e97480f014f1d9267e8126f1d0e58acd22f36aa
ToppCell	Severe-Myeloid-Mast-\|Severe / Condition, Lineage, Cell class and cell subclass	TPSD1 TPSAB1 TPSB2	1.13e-04	145	29	3	ce307d45425a5191882078f049f85477eec40b69
ToppCell	Severe-Myeloid-Mast\|Severe / Condition, Lineage, Cell class and cell subclass	TPSD1 TPSAB1 TPSB2	1.13e-04	145	29	3	e0bfd2ffdbd6c197ef0a04e983396ebd87ef7127
ToppCell	Children_(3_yrs)-Immune-mast_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TPSD1 TPSAB1 TPSB2	1.15e-04	146	29	3	f7349d63bb47f1f22ced8ff514edc1c11bc782e7
ToppCell	356C-Myeloid-Mast_cell\|356C / Donor, Lineage, Cell class and subclass (all cells)	TPSD1 TPSAB1 TPSB2	1.20e-04	148	29	3	1668d8a9e680da335362744f36b05446c499347e
ToppCell	356C-Myeloid-Mast_cell-\|356C / Donor, Lineage, Cell class and subclass (all cells)	TPSD1 TPSAB1 TPSB2	1.20e-04	148	29	3	18511ba10765eda937c5a710626361f7e6b9b321
ToppCell	-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	TPSD1 TPSAB1 ZNF831	1.20e-04	148	29	3	9952747a42e7875db92325f8edfab324951b29cc
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-myeloid-myeloid_granulocytic-basophil\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TPSD1 TPSAB1 TPSB2	1.25e-04	150	29	3	408b7c2c3a42f5455c8c26a83d9e366a1c8d5ecc
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic-Mast_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TPSD1 TPSAB1 TPSB2	1.27e-04	151	29	3	f5ae450e3daa10540ca8437d05efe2d86ac70960
ToppCell	368C-Myeloid-Mast_cell\|368C / Donor, Lineage, Cell class and subclass (all cells)	TPSD1 TPSAB1 TPSB2	1.30e-04	152	29	3	faf30245a1690aaa27c7be0832797c340e4af4d7
ToppCell	Tracheal-10x3prime_v2-Immune_Myeloid-Mast_cell-Mast_cell\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	TPSD1 TPSAB1 TPSB2	1.30e-04	152	29	3	321d322d58c12fd752de4e8ea873f3f367302813
ToppCell	368C-Myeloid-Mast_cell-\|368C / Donor, Lineage, Cell class and subclass (all cells)	TPSD1 TPSAB1 TPSB2	1.30e-04	152	29	3	519c9ed05fdaf420e42147ffae1dc05a7f86fdd4
ToppCell	Tracheal-10x3prime_v2-Immune_Myeloid-Mast_cell\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	TPSD1 TPSAB1 TPSB2	1.30e-04	152	29	3	a4d50e9af02231c5573aee905cf0905391e6da34
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Granulocytic\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TPSD1 TPSAB1 TPSB2	1.32e-04	153	29	3	83942ef63d21725fa15ed5a91481d1f9936e8f11
ToppCell	Adult-Immune-mast_cell-D122\|Adult / Lineage, Cell type, age group and donor	TPSD1 TPSAB1 TPSB2	1.37e-04	155	29	3	7c9de0591d1bf756b8e268b278bbe10bd5415dcd
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Granulocytic-Mast_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TPSD1 TPSAB1 TPSB2	1.37e-04	155	29	3	231fbbbd6e6f9c86be7a15a9ec0804e6b9ab3b5f
ToppCell	COVID-19-Mast_cells\|COVID-19 / group, cell type (main and fine annotations)	TPSD1 TPSAB1 TPSB2	1.40e-04	156	29	3	159504d43421ee83b9ab484816333ae549c9c2fd
ToppCell	COVID-19-Mast_cells-Mast_cells\|COVID-19 / group, cell type (main and fine annotations)	TPSD1 TPSAB1 TPSB2	1.40e-04	156	29	3	bc10b94673184ef384c6665b16a1209a8975a4f1
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_GRIP2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TPSD1 TPSB2 PRAMEF14	1.40e-04	156	29	3	1f558735fcd714c657a6ba5b1f187c8e95ca015b
ToppCell	Children_(3_yrs)-Immune-mast_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TPSD1 TPSAB1 TPSB2	1.42e-04	157	29	3	ec185dbeabb67fd9ca85f71cab88463b60f9b1c1
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	OPN4 PLA1A PACSIN1	1.48e-04	159	29	3	d3f81ba22160568ccaa6d2b04ebfd30630f9a6db
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_granulocytic-mast_cell\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TPSD1 TPSAB1 TPSB2	1.48e-04	159	29	3	ecd1daa33549541aee3bf4e139ab6732efc8e74c
ToppCell	10x5'-bone_marrow-Mast\|bone_marrow / Manually curated celltypes from each tissue	TPSD1 TPSAB1 TPSB2	1.48e-04	159	29	3	c3d3570e83c5d25cc92fa3a7a8f0dc2f89a72913
ToppCell	10x_3'_v3-thymus_(10x_3'_v3)-myeloid-myeloid_granulocytic\|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TPSD1 TPSAB1 TPSB2	1.48e-04	159	29	3	7b6370c9567da7d40541c6e243efa704ed7e90ae
ToppCell	343B-Myeloid-Mast_cell-\|343B / Donor, Lineage, Cell class and subclass (all cells)	TPSD1 TPSAB1 TPSB2	1.51e-04	160	29	3	a2f09b5955602819c8978f4372130c8ef915cd07
ToppCell	droplet-Fat-SCAT-30m-Hematologic-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPSAB1 CCDC187 TPSB2	1.51e-04	160	29	3	67ee7a314d7d4d3ea206e0158083f36f6dd7e80b
ToppCell	droplet-Fat-SCAT-30m-Hematologic-erythroblast\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPSAB1 CCDC187 TPSB2	1.51e-04	160	29	3	fc76337ad766c859db390ef8b6fb9caeaace3a56
ToppCell	343B-Myeloid-Mast_cell\|343B / Donor, Lineage, Cell class and subclass (all cells)	TPSD1 TPSAB1 TPSB2	1.51e-04	160	29	3	133ecae0a894d9a0d49d58859623359096b6f030
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Granulocytic-Mast_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TPSD1 TPSAB1 TPSB2	1.51e-04	160	29	3	fe9970c160159b35f6599ed13c89cfb49264d554
ToppCell	droplet-Fat-SCAT-30m-Hematologic\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPSAB1 CCDC187 TPSB2	1.51e-04	160	29	3	759749f708c3a2b36692d42499f19aff937e592f
ToppCell	Adult-Immune-mast_cell\|Adult / Lineage, Cell type, age group and donor	TPSD1 TPSAB1 TPSB2	1.53e-04	161	29	3	44f5c0256b3ce264a6c7b62740f32dcd45ee052d
ToppCell	10x5'-bone_marrow-Mast-Mast_cells\|bone_marrow / Manually curated celltypes from each tissue	TPSD1 TPSAB1 TPSB2	1.53e-04	161	29	3	15ba7e69699558353cfeecdcf1dbc2e147379ed6
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.4.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TPSD1 TPSAB1 TPSB2	1.53e-04	161	29	3	1f4614ae15bd2fc08e555cea4d0152c4a940d048
ToppCell	IIF-Other-HSPC\|IIF / Disease, Lineage and Cell Type	TPSD1 TPSAB1 TPSB2	1.59e-04	163	29	3	1e0d38fbed38ac48478868a1480172a1a3f7c1b7
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Granulocytic-Mast_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TPSD1 TPSAB1 TPSB2	1.62e-04	164	29	3	2c48c6e4eeee845f0563982d0bfa2a176ca5ef61
ToppCell	356C-Myeloid-Mast_cell\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	TPSD1 TPSAB1 TPSB2	1.62e-04	164	29	3	b3192c443f4848e6a8afdb89c155f9ec42a154b0
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TPSD1 TPSAB1 TPSB2	1.62e-04	164	29	3	2c929996a19bbe29949010928001c277b5494a42
ToppCell	356C-Myeloid-Mast_cell-\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	TPSD1 TPSAB1 TPSB2	1.62e-04	164	29	3	f7288ec4daf494dae770ea6c58bead27660ccae1
ToppCell	Multiple_Sclerosis-Other-HSPC\|Multiple_Sclerosis / Disease, Lineage and Cell Type	TPSD1 TPSAB1 TPSB2	1.62e-04	164	29	3	6af5529507d695b347adee4be5ead70f56c9cf55
ToppCell	Mild-Myeloid-Mast-\|Mild / Condition, Lineage, Cell class and cell subclass	TPSD1 TPSAB1 TPSB2	1.65e-04	165	29	3	93d3909a0f5f43d473d5005c842d7d73e25eceed
ToppCell	facs-Trachea-3m-Hematologic-myeloid-granulocyte-granulocyte_l26\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TPSAB1 PACSIN1 TPSB2	1.65e-04	165	29	3	23955e3373660f827518e723ac62fba99753f375
ToppCell	nucseq-Immune-Hematopoietic-Granulocytic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TPSD1 TPSAB1 TPSB2	1.65e-04	165	29	3	37615622c736e43260c38016e7c9e565ac97a3e8
ToppCell	Mild-Myeloid-Mast\|Mild / Condition, Lineage, Cell class and cell subclass	TPSD1 TPSAB1 TPSB2	1.65e-04	165	29	3	5fa9552c37890c5cc7e672a47038aebba2413cb4
ToppCell	nucseq-Immune-Hematopoietic-Granulocytic-Mast/Basophil\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TPSD1 TPSAB1 TPSB2	1.65e-04	165	29	3	640bb71e74a61df2fcb01ceeabe4c493ef836b21
ToppCell	nucseq-Immune-Hematopoietic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TPSD1 TPSAB1 TPSB2	1.65e-04	165	29	3	f3df74b5763130c71c0a482a3a23f6b22acc2892
ToppCell	droplet-Limb_Muscle-nan-3m-Myeloid-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPSAB1 LY6G6F TPSB2	1.68e-04	166	29	3	0a7992bc673fca546636563ec3fc17a4298ab6b1
ToppCell	343B-Myeloid-Mast_cell-\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	TPSD1 TPSAB1 TPSB2	1.68e-04	166	29	3	4e47e7f3019fb2dcbc35b4e9b47ee265a97cec5c
ToppCell	5'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TPSD1 TPSAB1 TPSB2	1.68e-04	166	29	3	a42268a02a89fc97272e45c4cbe21acf04b7428c
ToppCell	wk_20-22-Hematologic-Myeloid-Mast\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	TPSD1 TPSAB1 TPSB2	1.68e-04	166	29	3	004ab6a1425d812c7ce572205875fd702d4a9659
ToppCell	343B-Myeloid-Mast_cell\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	TPSD1 TPSAB1 TPSB2	1.68e-04	166	29	3	f6e2ec767c022982ef416fadb998a7b6b958f76a
ToppCell	5'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TPSD1 TPSAB1 TPSB2	1.71e-04	167	29	3	0aa1973141a2437df24c9857cd50ff3dfc7673c0
ToppCell	10x5'-lymph-node_spleen-Mast-Mast_cells\|lymph-node_spleen / Manually curated celltypes from each tissue	TPSD1 TPSAB1 TPSB2	1.74e-04	168	29	3	650ad3ea52577887885d82457dbc04202ce3eb34
ToppCell	Bronchial_Biopsy-Immune-Mast_cells\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	TPSD1 TPSAB1 TPSB2	1.74e-04	168	29	3	45ccc0cb42d21f4853190e8e9ed9a54aefefe738
ToppCell	3'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TPSD1 TPSAB1 TPSB2	1.74e-04	168	29	3	55f328353119cbdc521c782ebb8d163876f4186d
ToppCell	10x5'-lymph-node_spleen-Mast\|lymph-node_spleen / Manually curated celltypes from each tissue	TPSD1 TPSAB1 TPSB2	1.74e-04	168	29	3	e58ffbb57c81967766755c3f6f347b158a39cb0d
ToppCell	Adult-Endothelial-endothelial_cell_of_vein-D175\|Adult / Lineage, Cell type, age group and donor	SHE PLA1A NOS1	1.77e-04	169	29	3	e1f0298236e4a1c59077c14f0dd29a78fac12648
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	TPSD1 TPSAB1 TPSB2	1.77e-04	169	29	3	f47c4fbdc2a38745ec1b35104b85121c1413875a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SHE PLA1A NOS2	1.77e-04	169	29	3	987ff79ad563825dd9877ea8ccb536758f8c6700
ToppCell	Control-Mast_cells\|Control / group, cell type (main and fine annotations)	TPSD1 TPSAB1 TPSB2	1.77e-04	169	29	3	fdb9abca1d0f4fdc32dd8ac6231651ef34aa5afb
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TPSD1 TPSAB1 TPSB2	1.77e-04	169	29	3	2e15a9317da4017757d184f7cc91bd66b072ac51
ToppCell	10x5'v1-week_12-13-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	TPSD1 TPSAB1 TPSB2	1.77e-04	169	29	3	f68195510b91e287fe1507455ca067ece77a3897
ToppCell	COVID-19-lung-MAST\|lung / Disease (COVID-19 only), tissue and cell type	TPSD1 TPSAB1 TPSB2	1.80e-04	170	29	3	e90f18e5462381b38e918442b38b1c8105291908
ToppCell	Control-Myeloid-Mast\|Control / Disease state, Lineage and Cell class	TPSD1 TPSAB1 TPSB2	1.80e-04	170	29	3	9a14deb7f7cd4a49c217eba4023f7bf1dec6c902
Drug	Brunfelsamidine	TPSD1 TPSAB1 TPSB2	7.42e-09	4	29	3	CID005281683
Drug	ioxaglate	TPSD1 TPSAB1 TPSB2	6.48e-08	7	29	3	CID000003742
Drug	Telebrix	TPSD1 TPSAB1 TPSB2	6.48e-08	7	29	3	CID000034536
Drug	daphnodorin C	TPSD1 TPSAB1 TPSB2	1.55e-07	9	29	3	CID000072428
Drug	cromoglicate	TPSD1 TPSAB1 NOS2 TPSB2	2.08e-07	41	29	4	CID000027686
Drug	1c5s	TPSD1 TPSAB1 TPSB2	2.22e-07	10	29	3	CID000444753
Drug	AC1NUP69	TPSD1 TPSAB1 TPSB2	2.22e-07	10	29	3	CID005487154
Drug	Z-ala-ala-lys-mna	TPSD1 TPSAB1 TPSB2	3.04e-07	11	29	3	CID005486901
Drug	pimaradiene	TPSD1 TPSAB1 TPSB2	3.04e-07	11	29	3	CID000440909
Drug	daphnodorin A	TPSD1 TPSAB1 TPSB2	3.04e-07	11	29	3	CID000072426
Drug	AC1NSU64	TPSD1 TPSAB1 TPSB2	3.04e-07	11	29	3	CID005316303
Drug	methylhistamine	TPSD1 TPSAB1 TPSB2	3.04e-07	11	29	3	CID000000912
Drug	S)-bromoenol lactone	TPSD1 TPSAB1 PLA1A NOS2 TPSB2	3.85e-07	119	29	5	CID000002445
Drug	bis(5-amidino-2-benzimidazolyl)methane	TPSD1 TPSAB1 TPSB2	4.06e-07	12	29	3	CID000002386
Drug	NSC-648146	TPSD1 TPSAB1 TPSB2	4.06e-07	12	29	3	CID000372649
Drug	Elocom	TPSD1 TPSAB1 TPSB2	4.06e-07	12	29	3	CID000123620
Drug	4-amidinophenylpyruvic acid	TPSD1 TPSAB1 TPSB2	4.06e-07	12	29	3	CID000151496
Drug	Z-ARR-AFC	TPSD1 TPSAB1 TPSB2	5.27e-07	13	29	3	CID000125067
Drug	Nk3201	TPSD1 TPSAB1 TPSB2	5.27e-07	13	29	3	CID000213050
Drug	ABPH	TPSD1 TPSAB1 TPSB2	6.70e-07	14	29	3	CID000092377
Drug	ketotifen	TPSD1 TPSAB1 NOS2 TPSB2	8.00e-07	57	29	4	CID000003827
Drug	FdTTP	TPSD1 TPSAB1 TPSB2	8.37e-07	15	29	3	CID000162005
Drug	(E)-4-aminohex-4-enoic acid	TPSD1 TPSAB1 TPSB2	1.03e-06	16	29	3	CID005288385
Drug	terfenadine	TPSD1 TPSAB1 TPSB2 KCNH3	1.05e-06	61	29	4	CID000005405
Drug	sodium cromoglycate	TPSD1 TPSAB1 NOS2 TPSB2	1.20e-06	63	29	4	CID000002881
Drug	methylimidazoleacetic acid	TPSD1 TPSAB1 TPSB2	1.25e-06	17	29	3	CID000075810
Drug	H 17	TPSD1 TPSAB1 TPSB2	1.25e-06	17	29	3	CID000476867
Drug	2-azetidinone	TPSD1 TPSAB1 TPSB2	1.50e-06	18	29	3	CID000136721
Drug	N-Omega-Propyl-L-Arginine	NOS1 NOS2	1.57e-06	2	29	2	DB02644
Drug	N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine	NOS1 NOS2	1.57e-06	2	29	2	DB03449
Drug	A80a	TPSD1 TPSAB1 TPSB2	2.09e-06	20	29	3	CID005487000
Drug	atracurium besylate	TPSD1 TPSAB1 TPSB2	2.81e-06	22	29	3	CID000047320
Drug	Kinetensin	TPSD1 TPSAB1 TPSB2	3.23e-06	23	29	3	CID000147043
Drug	PL 0	TPSD1 TPSAB1 TPSB2	3.69e-06	24	29	3	CID000016157
Drug	CAS 79547-78-7	TPSD1 TPSAB1 TPSB2	4.19e-06	25	29	3	CID000003915
Drug	thymidine glycol monophosphate	TPSAB1 TPSB2	4.70e-06	3	29	2	CID000165415
Drug	N-(3-(Aminomethyl)Benzyl)Acetamidine	NOS1 NOS2	4.70e-06	3	29	2	DB02044
Drug	3-Bromo-7-Nitroindazole	NOS1 NOS2	4.70e-06	3	29	2	DB01997
Drug	CAS 83919-23-7	TPSD1 TPSAB1 TPSB2	4.74e-06	26	29	3	CID000004240
Drug	2-methylundecanal	TPSD1 TPSAB1 TPSB2	5.32e-06	27	29	3	CID000061031
Drug	B Ba	TPSD1 TPSAB1 TPSB2	6.64e-06	29	29	3	CID000001499
Drug	butter yellow	TPSD1 TPSAB1 TPSB2	7.37e-06	30	29	3	CID000007340
Drug	cKP	TPSD1 TPSAB1 TPSB2	7.37e-06	30	29	3	CID005494415
Drug	methacholine	TPSD1 TPSAB1 NOS1 NOS2 TPSB2	7.40e-06	217	29	5	CID000001993
Drug	AC1NS1E4	TPSD1 TPSAB1 TPSB2	8.15e-06	31	29	3	CID005326963
Drug	1,1/t,t	TPSD1 TPSAB1 TPSB2	8.15e-06	31	29	3	CID000444372
Drug	uPA inhibitor	TPSD1 TPSAB1 TPSB2	8.99e-06	32	29	3	CID000001746
Drug	(6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin	NOS1 NOS2	9.38e-06	4	29	2	DB02692
Drug	N-Omega-Hydroxy-L-Arginine	NOS1 NOS2	9.38e-06	4	29	2	DB03144
Drug	2-vinyl benzaldehyde	TPSD1 TPSAB1 NOS2 TPSB2	1.04e-05	108	29	4	CID000039391
Drug	atracurium	TPSD1 TPSAB1 TPSB2	1.18e-05	35	29	3	CID000047319
Drug	CI-U	TPSD1 TPSAB1 TPSB2	1.18e-05	35	29	3	CID000004357
Drug	tele-methylhistamine	TPSD1 TPSAB1 TPSB2	1.52e-05	38	29	3	CID000003614
Drug	GPGR	TPSD1 TPSAB1 TPSB2	1.52e-05	38	29	3	CID000485268
Drug	4-(nitroxy)butanoic acid 4-acetylaminophenyl ester	NOS1 NOS2	1.56e-05	5	29	2	ctd:C478738
Drug	isocoumarin	TPSD1 TPSAB1 TPSB2	1.65e-05	39	29	3	CID000068108
Drug	1-phenylimidazole	NOS1 NOS2 COQ6	1.65e-05	39	29	3	CID000081595
Drug	NSC89634	TPSD1 TPSAB1 TPSB2	1.65e-05	39	29	3	CID000070877
Drug	DB04623	TPSD1 TPSAB1 TPSB2	1.65e-05	39	29	3	CID005459358
Drug	NPGB	TPSD1 TPSAB1 TPSB2	1.92e-05	41	29	3	CID000030744
Drug	Attpsa	TPSAB1 TPSB2	2.34e-05	6	29	2	CID005487511
Drug	NapNa	NOS1 NOS2	2.34e-05	6	29	2	CID000128726
Drug	N-nitroso-L-arginine	NOS1 NOS2	2.34e-05	6	29	2	CID000127762
Drug	1-hexacosanol	NOS1 NOS2	2.34e-05	6	29	2	ctd:C051942
Drug	chrysoin	NOS1 NOS2 COQ6	2.72e-05	46	29	3	CID005464545
Drug	APMSF	TPSD1 TPSAB1 TPSB2	3.09e-05	48	29	3	CID000001719
Drug	AC1NLRUC	NOS1 NOS2	3.28e-05	7	29	2	CID004988604
Drug	2D7	TPSD1 TPSAB1 TPSB2	3.29e-05	49	29	3	CID005327103
Drug	bisphenol F	TPSD1 TPSAB1 TPSB2	3.71e-05	51	29	3	CID000012111
Drug	nedocromil sodium	TPSD1 TPSAB1 TPSB2	3.94e-05	52	29	3	CID000050294
Drug	cetirizine	TPSD1 TPSAB1 TPSB2	4.17e-05	53	29	3	CID000002678
Drug	I-As	TCERG1 PACSIN1 NOS1 NOS2	4.63e-05	158	29	4	CID000078017
Drug	TLCK	TPSD1 TPSAB1 NOS2 TPSB2	4.63e-05	158	29	4	CID000004427
Drug	loratadine	TPSD1 TPSAB1 TPSB2	4.92e-05	56	29	3	CID000003957
Drug	AC1LTNWX	TPSD1 TPSAB1 TPSB2	5.47e-05	58	29	3	CID001536427
Drug	Vi-o	NOS1 NOS2	5.61e-05	9	29	2	CID005289554
Drug	Reactive Nitrogen Species	NOS1 NOS2	5.61e-05	9	29	2	ctd:D026361
Drug	N-tosyl-L-phenylalanine chloromethyl ketone	TPSD1 TPSAB1 NOS2 TPSB2	5.61e-05	166	29	4	CID000009824
Drug	Substance P	TPSD1 TPSAB1 NOS1 NOS2 TPSB2	6.65e-05	343	29	5	CID000036511
Drug	fenpropathrin	TPSD1 TPSAB1 TPSB2	6.68e-05	62	29	3	CID000047326
Drug	KMUP 1	NOS1 NOS2	7.00e-05	10	29	2	ctd:C439304
Drug	BAEE	TPSD1 NOS1 NOS2	7.35e-05	64	29	3	CID000123880
Drug	succinylcholine	TPSD1 TPSAB1 TPSB2	7.35e-05	64	29	3	CID000005314
Drug	AGEPC	TPSD1 TPSAB1 PLA1A NOS2 TPSB2	7.92e-05	356	29	5	CID000461545
Drug	benzoyl isothiocyanate	NOS1 NOS2	8.55e-05	11	29	2	CID000068284
Drug	guanidinoglutaric acid	NOS1 NOS2	8.55e-05	11	29	2	CID000002105
Drug	di-n-butyltin	NOS1 NOS2	8.55e-05	11	29	2	ctd:C056189
Drug	cetraxate	NOS1 NOS2	8.55e-05	11	29	2	CID000002680
Drug	N-(4-O-glycerol-3-methoxybenzyl)nonivamide	NOS1 NOS2	8.55e-05	11	29	2	ctd:C080418
Drug	metronidazole	TPSD1 TPSAB1 TPSB2	9.20e-05	69	29	3	CID000004173
Drug	L-3-(2-naphthyl)alanine	TPSD1 TPSAB1 TPSB2	9.60e-05	70	29	3	CID000185915
Drug	naphthol AS-D chloroacetate	TPSD1 TPSAB1 TPSB2	1.00e-04	71	29	3	CID000160247
Drug	p-toluidine	TPSD1 TPSAB1 TPSB2	1.00e-04	71	29	3	CID000007813
Drug	B-H-H	NOS1 NOS2	1.03e-04	12	29	2	CID000447030
Drug	L-Citrulline	NOS1 NOS2	1.03e-04	12	29	2	DB00155
Drug	thaliporphine	NOS1 NOS2	1.03e-04	12	29	2	CID000100020
Drug	Tropicamide	NOS1 NOS2	1.03e-04	12	29	2	ctd:D014331
Drug	salmeterol	TPSD1 TPSAB1 TPSB2	1.04e-04	72	29	3	CID000005152
Drug	oxypurinol	SHE NOS1 NOS2	1.04e-04	72	29	3	CID000004644
Drug	chloromethyl	TPSD1 TPSAB1 NOS2 TPSB2	1.05e-04	195	29	4	CID000007835
Disease	tryptase beta-2 measurement	TPSD1 TPSAB1 TPSB2	5.08e-08	9	26	3	EFO_0008306
Disease	sialic acid-binding Ig-like lectin 9 measurement	SIGLEC12 SIGLEC9	2.68e-05	9	26	2	EFO_0008286
Disease	retinopathy of prematurity (biomarker_via_orthology)	NOS1 NOS2	4.90e-05	12	26	2	DOID:13025 (biomarker_via_orthology)
Disease	hepatic encephalopathy (biomarker_via_orthology)	NOS1 NOS2	7.78e-05	15	26	2	DOID:13413 (biomarker_via_orthology)
Disease	urticaria	TPSAB1 TPSB2	1.40e-04	20	26	2	EFO_0005531
Disease	impotence (biomarker_via_orthology)	NOS1 NOS2	1.71e-04	22	26	2	DOID:1875 (biomarker_via_orthology)
Disease	systemic mastocytosis	TPSD1 TPSAB1	2.21e-04	25	26	2	MONDO_0016586
Disease	lissencephaly (implicated_via_orthology)	NOS1 NOS2	2.59e-04	27	26	2	DOID:0050453 (implicated_via_orthology)
Disease	basophil measurement	TPSAB1 TPSB2	1.28e-03	60	26	2	EFO_0803539
Disease	cystic fibrosis (is_marker_for)	NOS1 NOS2	1.37e-03	62	26	2	DOID:1485 (is_marker_for)
Disease	Petit mal status	NOS1 NOS2	1.59e-03	67	26	2	C0270823
Disease	Status Epilepticus, Subclinical	NOS1 NOS2	1.59e-03	67	26	2	C0751522
Disease	Simple Partial Status Epilepticus	NOS1 NOS2	1.59e-03	67	26	2	C0751524
Disease	Non-Convulsive Status Epilepticus	NOS1 NOS2	1.59e-03	67	26	2	C0751523
Disease	Grand Mal Status Epilepticus	NOS1 NOS2	1.59e-03	67	26	2	C0311335
Disease	Complex Partial Status Epilepticus	NOS1 NOS2	1.59e-03	67	26	2	C0393734
Disease	Status Epilepticus	NOS1 NOS2	1.64e-03	68	26	2	C0038220
Disease	Mechanical Allodynia	NOS1 NOS2	2.49e-03	84	26	2	C2936719
Disease	Hyperalgesia	NOS1 NOS2	2.49e-03	84	26	2	C0020429
Disease	Allodynia	NOS1 NOS2	2.49e-03	84	26	2	C0458247
Disease	Hyperalgesia, Secondary	NOS1 NOS2	2.49e-03	84	26	2	C0751212
Disease	Hyperalgesia, Primary	NOS1 NOS2	2.49e-03	84	26	2	C0751211
Disease	Hyperalgesia, Thermal	NOS1 NOS2	2.49e-03	84	26	2	C0751214
Disease	Tactile Allodynia	NOS1 NOS2	2.49e-03	84	26	2	C0751213
Disease	chronic obstructive pulmonary disease (is_marker_for)	NOS1 NOS2	3.30e-03	97	26	2	DOID:3083 (is_marker_for)
Disease	Visual seizure	NOS1 NOS2	3.57e-03	101	26	2	C0270824
Disease	Epileptic drop attack	NOS1 NOS2	3.57e-03	101	26	2	C0270846
Disease	Generalized seizures	NOS1 NOS2	3.57e-03	101	26	2	C0234533
Disease	Clonic Seizures	NOS1 NOS2	3.57e-03	101	26	2	C0234535
Disease	Vertiginous seizure	NOS1 NOS2	3.57e-03	101	26	2	C0422855
Disease	Gustatory seizure	NOS1 NOS2	3.57e-03	101	26	2	C0422854
Disease	Seizures, Somatosensory	NOS1 NOS2	3.57e-03	101	26	2	C0422850
Disease	Olfactory seizure	NOS1 NOS2	3.57e-03	101	26	2	C0422853

Protein segments in the cluster

Peptide	Gene	Start	Entry
MGWVIPEWPGAQSCP	nan	1	Q8N814
SMDPHWPSLGVWGSP	CDX4	61	O14627
WGKACSLPMWSTGPE	CCDC187	91	A0A096LP49
PSWWPFEMSPGVLTF	ACBD5	496	Q5T8D3
LTAQPVPPEMCSGWW	BAZ2A	1426	Q9UIF9
WPCPFPMADSSPWVH	COQ6	176	Q9Y2Z9
FGSPADSWWRPEPTM	DHX30	146	Q7L2E3
LMAPWPWGPPASQSS	KCNH3	971	Q9ULD8
SPALCAPSTGWDMPW	LY6G6F	221	Q5SQ64
GCPADWIWLVPPMSG	NOS2	456	P35228
SGYPWWPCMVSADPL	NSD2	231	O96028
GCPADWVWIVPPMSG	NOS1	676	P29475
WFRSTSGPGMPMNWP	PACSIN1	286	Q9BY11
EPSCMATPAPPSWWD	OPN4	16	Q9UHM6
CTGIWPRSAAQWPMP	MAB21L2	176	Q9Y586
MAVPSLWPWGACLPV	INSRR	1	P14616
WPGAWALSCFPETMS	PRAMEF13	116	Q5VWM6
WPFWMGSPPDSVLAE	RUSC2	1341	Q8N2Y8
SETFPPGMPCWVTGW	TPSAB1	146	Q15661
PGMPCWVTGWGDVDN	TPSAB1	151	Q15661
SETFPPGMPCWVTGW	TPSB2	146	P20231
PGMPCWVTGWGDVDN	TPSB2	151	P20231
FPPGMPCWVTGWGDV	TPSD1	156	Q9BZJ3
CPVPGGWCPWSEWTM	SSPOP	3406	A2VEC9
WPGAWALSCFPETMS	PRAMEF14	116	Q5SWL7
VPWACEQGTPPMISW	SIGLEC9	166	Q9Y336
SWWMENGPGCLVTPV	NKAIN1	106	Q4KMZ8
PWACEQGTPPTITWM	SIGLEC12	296	Q96PQ1
MPPGPWESCFWVGGL	PLA1A	1	Q53H76
TAPIPGTPWCVVWTG	TCERG1	526	O14776
WTWTSPGEGGPAQMS	ZNF831	1231	Q5JPB2
MQWSPTPGASACLGW	SHE	1	Q5VZ18
WPMKFGSPDWAQVPC	PIFO	146	Q8TCI5