Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessmRNA splicing, via spliceosome

RBM10 RBM5 PRPF39 HNRNPUL1

3.96e-05358124GO:0000398
GeneOntologyBiologicalProcessRNA splicing, via transesterification reactions with bulged adenosine as nucleophile

RBM10 RBM5 PRPF39 HNRNPUL1

3.96e-05358124GO:0000377
GeneOntologyBiologicalProcessRNA splicing, via transesterification reactions

RBM10 RBM5 PRPF39 HNRNPUL1

4.13e-05362124GO:0000375
GeneOntologyBiologicalProcessmRNA metabolic process

RBM10 BOLL RBM5 PRPF39 HNRNPUL1

1.05e-04917125GO:0016071
GeneOntologyBiologicalProcess3'-UTR-mediated mRNA stabilization

RBM10 BOLL

1.43e-0431122GO:0070935
GeneOntologyBiologicalProcessRNA splicing

RBM10 RBM5 PRPF39 HNRNPUL1

1.47e-04502124GO:0008380
GeneOntologyBiologicalProcessmRNA processing

RBM10 RBM5 PRPF39 HNRNPUL1

2.10e-04551124GO:0006397
GeneOntologyBiologicalProcessmRNA stabilization

RBM10 BOLL

8.86e-0477122GO:0048255
GeneOntologyBiologicalProcessalternative mRNA splicing, via spliceosome

RBM5 HNRNPUL1

9.32e-0479122GO:0000380
GeneOntologyBiologicalProcessnegative regulation of mRNA catabolic process

RBM10 BOLL

1.13e-0387122GO:1902373
GeneOntologyBiologicalProcessRNA stabilization

RBM10 BOLL

1.16e-0388122GO:0043489
GeneOntologyBiologicalProcessspliceosomal complex assembly

RBM5 PRPF39

1.46e-0399122GO:0000245
GeneOntologyBiologicalProcessnegative regulation of RNA catabolic process

RBM10 BOLL

1.52e-03101122GO:1902369
GeneOntologyBiologicalProcessregulation of mRNA metabolic process

RBM10 BOLL RBM5

1.87e-03443123GO:1903311
GeneOntologyBiologicalProcessnegative regulation of mRNA metabolic process

RBM10 BOLL

1.96e-03115122GO:1903312
GeneOntologyBiologicalProcessregulation of mRNA splicing, via spliceosome

RBM10 RBM5

2.46e-03129122GO:0048024
GeneOntologyBiologicalProcessribonucleoprotein complex biogenesis

RBM10 RBM5 PRPF39

2.88e-03515123GO:0022613
GeneOntologyBiologicalProcesspositive regulation of DNA repair

FAM168A EYA3

3.01e-03143122GO:0045739
GeneOntologyBiologicalProcessregulation of mRNA processing

RBM10 RBM5

3.66e-03158122GO:0050684
GeneOntologyCellularComponentspliceosomal complex

RBM5 PRPF39

6.49e-03215122GO:0005681
MousePhenoarrest of spermiogenesis

BOLL RBM5

6.41e-052572MP:0008279
MousePhenoabnormal spermiogenesis

KMT2E BOLL RBM5

1.60e-0423773MP:0001932
Domain-

RBM10 RBM5

1.42e-05101124.10.1060.10
Domainzf-RanBP

RBM10 RBM5

7.24e-0522112PF00641
DomainZnF_RBZ

RBM10 RBM5

7.92e-0523112SM00547
DomainG_PATCH

RBM10 RBM5

7.92e-0523112PS50174
DomainG_patch

RBM10 RBM5

7.92e-0523112SM00443
DomainG_patch_dom

RBM10 RBM5

7.92e-0523112IPR000467
DomainG-patch

RBM10 RBM5

7.92e-0523112PF01585
DomainZF_RANBP2_2

RBM10 RBM5

7.92e-0523112PS50199
DomainZF_RANBP2_1

RBM10 RBM5

8.64e-0524112PS01358
DomainZnf_RanBP2

RBM10 RBM5

9.39e-0525112IPR001876
DomainRRM_1

RBM10 BOLL RBM5

2.10e-04208113PF00076
DomainRRM

RBM10 BOLL RBM5

2.38e-04217113SM00360
DomainRRM_dom

RBM10 BOLL RBM5

2.72e-04227113IPR000504
DomainRRM

RBM10 BOLL RBM5

2.83e-04230113PS50102
Domain-

RBM10 BOLL RBM5

3.36e-042441133.30.70.330
DomainNucleotide-bd_a/b_plait

RBM10 BOLL RBM5

3.96e-04258113IPR012677
PathwayWP_MRNA_PROCESSING

RBM10 BOLL RBM5

6.05e-0445163MM15946
PathwayREACTOME_MRNA_SPLICING

RBM10 RBM5

2.92e-0320162MM15411
PathwayREACTOME_MRNA_SPLICING

RBM10 RBM5

3.24e-0321262M14033
PathwayREACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

RBM10 RBM5

5.48e-0327762MM15414
PathwayREACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

RBM10 RBM5

5.71e-0328362M13087
Pubmed

RBM10 promotes transformation-associated processes in small cell lung cancer and is directly regulated by RBM5.

RBM10 RBM5

1.09e-07212228662214
Pubmed

Autoregulation of RBM10 and cross-regulation of RBM10/RBM5 via alternative splicing-coupled nonsense-mediated decay.

RBM10 RBM5

1.09e-07212228586478
Pubmed

Co- and post-transcriptional regulation of Rbm5 and Rbm10 in mouse cells as evidenced by tissue-specific, developmental and disease-associated variation of splice variant and protein expression levels.

RBM10 RBM5

3.27e-07312226784654
Pubmed

RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation.

RBM10 RBM5

6.55e-07412224332178
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

RBM10 RBM5 LENG8 PRPF39 HNRNPUL1 EYA3

7.87e-07110312634189442
Pubmed

A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.

RBM10 RBM5 PRPF39 HNRNPUL1

9.16e-0723212425515538
Pubmed

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

RBM10 RBM5 LENG8 HNRNPUL1

1.25e-0625112431076518
Pubmed

mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.

RBM10 RBM5 PRPF39 HNRNPUL1

1.78e-0627412434244482
Pubmed

Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression.

TFG PRPF39 HNRNPUL1

3.62e-069012333087562
Pubmed

Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.

RBM10 RBM5 HNRNPUL1

7.58e-0611512317332742
Pubmed

rec-YnH enables simultaneous many-by-many detection of direct protein-protein and protein-RNA interactions.

RBM10 RBM5 SLAIN1

1.43e-0514212330217970
Pubmed

Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.

RBM10 RBM5 TFG HNRNPUL1

2.79e-0555112434728620
Pubmed

Dynamic protein-protein interaction wiring of the human spliceosome.

RBM10 RBM5 HNRNPUL1

3.79e-0519712322365833
Pubmed

Proline-rich sequence recognition: II. Proteomics analysis of Tsg101 ubiquitin-E2-like variant (UEV) interactions.

TFG HNRNPUL1

5.38e-053212219542561
Pubmed

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.

RBM10 RBM5 PRPF39 SLAIN1

8.03e-0572312434133714
Pubmed

Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.

RBM10 TFG LENG8 HNRNPUL1

8.11e-0572512427025967
Pubmed

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

FAM168A RBM10 RBM5 TFG

8.87e-0574212426871637
Pubmed

Identification of differential protein interactors of lamin A and progerin.

RBM10 HNRNPUL1

1.60e-045512221327095
Pubmed

Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.

RBM10 HNRNPUL1

1.72e-045712217932509
Pubmed

Tagging genes with cassette-exchange sites.

RBM5 TFG EYA3

1.83e-0433512315741177
Pubmed

A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.

RBM10 BOLL RBM5

2.03e-0434712316033648
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

FAM168A RBM10 LENG8 HNRNPUL1

2.34e-0495412436373674
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

RBM10 RBM5 LENG8 HNRNPUL1

2.68e-0498912436424410
InteractionDMRTB1 interactions

LENG8 PRPF39 HNRNPUL1 SLAIN1

2.13e-0794124int:DMRTB1
InteractionSF3A2 interactions

RBM10 RBM5 TFG PRPF39 HNRNPUL1

3.22e-07273125int:SF3A2
InteractionBOLL interactions

FAM168A BOLL TFG

1.83e-0642123int:BOLL
InteractionPATZ1 interactions

FAM168A RBM10 BOLL SLAIN1

1.94e-06163124int:PATZ1
InteractionMAPK1IP1L interactions

TFG LENG8 HNRNPUL1

2.26e-0645123int:MAPK1IP1L
InteractionTFG interactions

FAM168A BOLL TFG LENG8

1.20e-05258124int:TFG
InteractionSNRNP40 interactions

RBM10 RBM5 LENG8 HNRNPUL1 EYA3

2.05e-05637125int:SNRNP40
InteractionSF1 interactions

FAM168A RBM10 PRPF39 HNRNPUL1

2.28e-05304124int:SF1
InteractionSMG7 interactions

RBM10 RBM5 LENG8 HNRNPUL1

2.76e-05319124int:SMG7
InteractionGLDC interactions

RBM10 RBM5 PRPF39 HNRNPUL1

2.83e-05321124int:GLDC
InteractionRHOXF2 interactions

FAM168A BOLL LENG8

2.84e-05104123int:RHOXF2
InteractionPRR20A interactions

FAM168A RBM10 TFG

3.27e-05109123int:PRR20A
InteractionRBPMS interactions

FAM168A BOLL TFG SLAIN1

3.54e-05340124int:RBPMS
InteractionCEBPA interactions

RBM10 RBM5 LENG8 PRPF39 HNRNPUL1 EYA3

3.67e-051245126int:CEBPA
InteractionMYCN interactions

FAM168A RBM10 TFG LENG8 PRPF39 HNRNPUL1

6.39e-051373126int:MYCN
InteractionVPS37C interactions

FAM168A TFG HNRNPUL1

7.04e-05141123int:VPS37C
InteractionFAM168A interactions

FAM168A BOLL TFG

7.19e-05142123int:FAM168A
InteractionSNRPC interactions

FAM168A RBM10 BOLL HNRNPUL1

9.65e-05440124int:SNRPC
InteractionNDEL1 interactions

RBM10 RBM5 SLAIN1

1.10e-04164123int:NDEL1
InteractionRAD18 interactions

RBM10 RBM5 LENG8 HNRNPUL1

1.12e-04457124int:RAD18
InteractionFBXW11 interactions

RBM10 RBM5 PRPF39 HNRNPUL1

1.28e-04473124int:FBXW11
InteractionCPSF6 interactions

FAM168A RBM10 LENG8 HNRNPUL1

1.92e-04526124int:CPSF6
InteractionNR4A1 interactions

TFG PRPF39 HNRNPUL1

2.35e-04212123int:NR4A1
InteractionCUL2 interactions

TFG PRPF39 HNRNPUL1 SLAIN1

3.00e-04591124int:CUL2
InteractionLASP1 interactions

FAM168A TFG LENG8

3.69e-04247123int:LASP1
InteractionZNF34 interactions

TFG LENG8

3.76e-0449122int:ZNF34
InteractionDCUN1D1 interactions

FAM168A TFG HNRNPUL1

5.05e-04275123int:DCUN1D1
InteractionCELF1 interactions

RBM10 RBM5 HNRNPUL1

5.77e-04288123int:CELF1
InteractionDHX8 interactions

RBM10 RBM5 LENG8

6.01e-04292123int:DHX8
InteractionC10orf55 interactions

FAM168A LENG8

6.62e-0465122int:C10orf55
InteractionTSG101 interactions

TFG LENG8 HNRNPUL1

6.69e-04303123int:TSG101
InteractionSP7 interactions

RBM10 LENG8 EYA3

6.76e-04304123int:SP7
InteractionKIF9 interactions

RBM5 SLAIN1

7.67e-0470122int:KIF9
InteractionCPSF7 interactions

RBM10 LENG8 SLAIN1

9.19e-04338123int:CPSF7
InteractionUBQLN2 interactions

FAM168A RBM10 TFG EYA3

9.32e-04797124int:UBQLN2
InteractionSF3B4 interactions

RBM10 TFG HNRNPUL1

9.51e-04342123int:SF3B4
InteractionSAXO4 interactions

TFG SLAIN1

1.00e-0380122int:SAXO4
InteractionRBPMS2 interactions

FAM168A BOLL

1.08e-0383122int:RBPMS2
InteractionTOLLIP interactions

FAM168A TFG PRPF39

1.09e-03358123int:TOLLIP
InteractionDDA1 interactions

RBM5 HNRNPUL1 EYA3

1.18e-03368123int:DDA1
InteractionSLAIN1 interactions

RBM10 SLAIN1

1.18e-0387122int:SLAIN1
InteractionTFAP2D interactions

FAM168A SLAIN1

1.24e-0389122int:TFAP2D
InteractionPRR20B interactions

FAM168A TFG

1.26e-0390122int:PRR20B
InteractionPRR20C interactions

FAM168A TFG

1.26e-0390122int:PRR20C
InteractionPRR20D interactions

FAM168A TFG

1.26e-0390122int:PRR20D
InteractionBABAM2 interactions

FAM168A TFG

1.41e-0395122int:BABAM2
InteractionCAND1 interactions

TFG LENG8 PRPF39 HNRNPUL1

1.43e-03894124int:CAND1
InteractionFHL2 interactions

RBM5 EYA3 SLAIN1

1.45e-03396123int:FHL2
InteractionEWSR1 interactions

FAM168A TFG HNRNPUL1 EYA3

1.50e-03906124int:EWSR1
InteractionPRR20E interactions

FAM168A TFG

1.59e-03101122int:PRR20E
InteractionMIRLET7D interactions

RBM10 RBM5

1.59e-03101122int:MIRLET7D
InteractionINTS11 interactions

TFG LENG8

1.59e-03101122int:INTS11
InteractionPRMT1 interactions

RBM10 RBM5 TFG HNRNPUL1

1.65e-03929124int:PRMT1
InteractionC1orf94 interactions

FAM168A BOLL

1.65e-03103122int:C1orf94
InteractionBABAM1 interactions

FAM168A TFG

1.72e-03105122int:BABAM1
InteractionMIRLET7E interactions

RBM10 RBM5

1.75e-03106122int:MIRLET7E
InteractionHNRNPA1 interactions

RBM10 RBM5 LENG8 HNRNPUL1

1.76e-03945124int:HNRNPA1
InteractionDDX17 interactions

RBM10 RBM5 HNRNPUL1

1.79e-03426123int:DDX17
InteractionPEF1 interactions

FAM168A TFG

1.81e-03108122int:PEF1
InteractionSMN2 interactions

LENG8 HNRNPUL1

2.02e-03114122int:SMN2
InteractionMIRLET7I interactions

RBM10 RBM5

2.02e-03114122int:MIRLET7I
InteractionMIRLET7G interactions

RBM10 RBM5

2.12e-03117122int:MIRLET7G
InteractionSMC5 interactions

FAM168A RBM10 LENG8 HNRNPUL1

2.16e-031000124int:SMC5
InteractionFBXO11 interactions

FAM168A TFG

2.23e-03120122int:FBXO11
InteractionHYPK interactions

BOLL LENG8

2.42e-03125122int:HYPK
InteractionSNRPA interactions

RBM10 LENG8 HNRNPUL1

2.55e-03482123int:SNRPA
InteractionR3HDM2 interactions

FAM168A TFG

2.57e-03129122int:R3HDM2
InteractionDHX15 interactions

RBM10 RBM5 HNRNPUL1

2.86e-03502123int:DHX15
InteractionNAF1 interactions

FAM168A BOLL

2.94e-03138122int:NAF1
InteractionCOPS5 interactions

RBM5 TFG PRPF39 HNRNPUL1

3.09e-031102124int:COPS5
InteractionERG28 interactions

TFG HNRNPUL1

3.11e-03142122int:ERG28
InteractionPHB1 interactions

RBM10 TFG LENG8 HNRNPUL1

3.31e-031123124int:PHB1
InteractionARID5A interactions

BOLL LENG8

3.32e-03147122int:ARID5A
InteractionCRMP1 interactions

TFG HNRNPUL1

3.37e-03148122int:CRMP1
InteractionTP53BP1 interactions

RBM10 RBM5 HNRNPUL1

3.39e-03533123int:TP53BP1
GeneFamilyZinc fingers RANBP2-type |RNA binding motif containing

RBM10 RBM5

1.28e-05215289
GeneFamilyG-patch domain containing|Minor histocompatibility antigens

RBM10 RBM5

1.41e-052252579
GeneFamilyRNA binding motif containing

RBM10 BOLL RBM5

1.58e-0521353725
CoexpressionZHANG_BREAST_CANCER_PROGENITORS_DN

RBM5 PRPF39 EYA3

3.30e-05142123M6489
CoexpressionZHANG_BREAST_CANCER_PROGENITORS_DN

RBM5 PRPF39 EYA3

4.63e-05159123MM760
CoexpressionGSE17721_POLYIC_VS_PAM3CSK4_1H_BMDC_UP

RBM10 RBM5 HNRNPUL1

9.02e-05199123M3824
CoexpressionGSE15330_LYMPHOID_MULTIPOTENT_VS_GRANULOCYTE_MONOCYTE_PROGENITOR_DN

RBM10 HNRNPUL1 SLAIN1

9.15e-05200123M7059
CoexpressionGSE36009_UNSTIM_VS_LPS_STIM_DC_DN

KMT2E RBM5 EYA3

9.15e-05200123M8774
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

RBM5 LENG8

7.48e-045092GAVISH_3CA_METAPROGRAM_FIBROBLASTS_CAF_4
ComputationalNeighborhood of SNRP70

RBM5 HNRNPUL1

1.15e-036292MORF_SNRP70
ComputationalRNA splicing.

RBM5 HNRNPUL1

1.26e-036592MODULE_183
DiseaseColorectal Carcinoma

RBM10 BOLL TFG

1.92e-03702113C0009402
DiseaseIntellectual Disability

KMT2E TFG

1.15e-02447112C3714756

Protein segments in the cluster

PeptideGeneStartEntry
YQQPAYHYQATTQYL

BOLL

176

Q8N9W6
DPNSQYYYNAQSQQY

RBM10

591

P98175
YQTLQQTQPYAVYPQ

EYA3

96

Q99504
YPQQNLYAQGAYYTQ

FAM168A

141

Q92567
LQQQQYYQWYQQYNY

LENG8

81

Q96PV6
YYQNQQPSANFQNYN

KMT2E

1556

Q8IZD2
DPNSQYYYNSLTQQY

RBM5

481

P52756
QYNYQNPWNYGQYYP

PRPF39

651

Q86UA1
QTYPQPSYNQYQQYA

HNRNPUL1

806

Q9BUJ2
SSQYFPSNNYQQQQY

SLAIN1

366

Q8ND83
PSNNYQQQQYYSPQA

SLAIN1

371

Q8ND83
PQQYQASNYPAQTYT

TFG

316

Q92734
QPYEYNESFYQNPNF

ZNF487

381

B1APH4