Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	Rab GDP-dissociation inhibitor activity	GDI1 GDI2	1.51e-05	2	78	2	GO:0005093
GeneOntologyMolecularFunction	small GTPase binding	BICD2 CDKL5 RANBP2 MYO5B KIF16B OCRL GDI1 GDI2	3.61e-05	321	78	8	GO:0031267
GeneOntologyMolecularFunction	GTPase binding	BICD2 CDKL5 RANBP2 MYO5B KIF16B OCRL GDI1 GDI2	8.07e-05	360	78	8	GO:0051020
GeneOntologyMolecularFunction	cytoskeletal motor activity	KIF18A MYO5B KIF16B MYO1B DYNC1H1	9.90e-05	118	78	5	GO:0003774
Domain	HECW_N	HECW1 HECW2	1.59e-05	2	75	2	IPR032348
Domain	RabGDI	GDI1 GDI2	1.59e-05	2	75	2	IPR000806
Domain	HECW_N	HECW1 HECW2	1.59e-05	2	75	2	PF16562
Domain	-	UTP6 RANBP2 TRANK1 HELZ INTS8 IFIT2 CRTAP	1.95e-05	207	75	7	1.25.40.10
Domain	TPR-like_helical_dom	UTP6 RANBP2 TRANK1 HELZ INTS8 IFIT2 CRTAP	4.15e-05	233	75	7	IPR011990
Domain	GDI	GDI1 GDI2	9.50e-05	4	75	2	PF00996
Domain	GDP_dissociation_inhibitor	GDI1 GDI2	9.50e-05	4	75	2	IPR018203
Domain	P-loop_NTPase	KIF18A RRAS2 TRANK1 MYO5B KIF16B HELZ MYO1B ZNFX1 CHD7 GNAS TEP1 DYNC1H1	1.33e-04	848	75	12	IPR027417
Domain	HECT	HECW1 HECW2 HUWE1	1.70e-04	27	75	3	PF00632
Domain	HECTc	HECW1 HECW2 HUWE1	1.70e-04	27	75	3	SM00119
Domain	HECT_dom	HECW1 HECW2 HUWE1	1.70e-04	27	75	3	IPR000569
Domain	HECT	HECW1 HECW2 HUWE1	1.70e-04	27	75	3	PS50237
Domain	VDCC_a1su_IQ	CACNA1B CACNA1F	3.30e-04	7	75	2	IPR014873
Domain	GPHH	CACNA1B CACNA1F	3.30e-04	7	75	2	PF16905
Domain	GPHH_dom	CACNA1B CACNA1F	3.30e-04	7	75	2	IPR031649
Domain	Ca_chan_IQ	CACNA1B CACNA1F	3.30e-04	7	75	2	SM01062
Domain	Ca_chan_IQ	CACNA1B CACNA1F	3.30e-04	7	75	2	PF08763
Domain	VDCCAlpha1	CACNA1B CACNA1F	7.01e-04	10	75	2	IPR002077
Domain	WW	HECW1 TCERG1 HECW2	8.88e-04	47	75	3	PF00397
Domain	WW	HECW1 TCERG1 HECW2	9.45e-04	48	75	3	SM00456
Domain	WW_DOMAIN_2	HECW1 TCERG1 HECW2	1.13e-03	51	75	3	PS50020
Domain	WW_DOMAIN_1	HECW1 TCERG1 HECW2	1.13e-03	51	75	3	PS01159
Domain	WW_dom	HECW1 TCERG1 HECW2	1.19e-03	52	75	3	IPR001202
Domain	UIM	STAM2 HUWE1	4.15e-03	24	75	2	PS50330
Domain	TPR_REGION	RANBP2 TRANK1 INTS8 IFIT2	4.39e-03	165	75	4	PS50293
Domain	TPR	RANBP2 TRANK1 INTS8 IFIT2	4.39e-03	165	75	4	PS50005
Domain	UIM_dom	STAM2 HUWE1	4.50e-03	25	75	2	IPR003903
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	BICD2 UBE2I TCERG1 NFE2L2 ZNF655 CCDC15 ZNFX1 EXOC1 CACHD1 ANKRD36 HUWE1 GDI1 INTS8 DYNC1H1 FAF1 CRTAP	2.65e-08	1285	79	16	35914814
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	RANBP2 LRCH2 SBF1 NFE2L2 HELZ CACHD1 HUWE1 DYNC1H1	6.03e-08	232	79	8	25515538
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	RANBP2 LRCH2 HECW1 SBF1 PURA DPYSL4 ZNFX1 CHD7 HUWE1 GRM2 GDI1 GDI2 DYNC1H1	2.53e-07	963	79	13	28671696
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	UTP6 RANBP2 SBF1 RBM6 HELZ MYO1B CHD7 HUWE1 GDI1 GDI2 DYNC1H1	2.67e-07	653	79	11	22586326
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	CDKL5 LRCH2 SBF1 MYO5B HECW2 PURA PSD3 DPYSL4 OPA3 ZNFX1 EXOC1 GRM2 GDI1 GDI2 DYNC1H1	6.90e-07	1431	79	15	37142655
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	RANBP2 MYO5B PSD3 ANKRD11 RBM6 MYO1B DYNC1H1	2.97e-06	272	79	7	31010829
Pubmed	Differential effects of sumoylation on transcription and alternative splicing by transcription elongation regulator 1 (TCERG1).	UBE2I TCERG1	5.09e-06	2	79	2	20215116
Pubmed	Cloning of a brain-type isoform of human Rab GDI and its expression in human neuroblastoma cell lines and tumor specimens.	GDI1 GDI2	5.09e-06	2	79	2	7585614
Pubmed	The RanBP2 SUMO E3 ligase is neither HECT- nor RING-type.	RANBP2 UBE2I	5.09e-06	2	79	2	15378033
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	RANBP2 PURA EXOC1 CHD7 GNAS HUWE1 INTS8 DYNC1H1 FAF1	7.03e-06	582	79	9	20467437
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	BICD2 STAM2 TCERG1 RBM6 HELZ MYO1B CHD7 GNAS HUWE1	7.64e-06	588	79	9	38580884
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	UTP6 RANBP2 RRAS2 SBF1 TFB1M TCERG1 MYO1B CHCHD6 EXOC1 CHD7 OCRL HUWE1 DYNC1H1	1.07e-05	1353	79	13	29467282
Pubmed	An Alternative Splicing Program for Mouse Craniofacial Development.	MYO1B EXOC1 OCRL	1.46e-05	21	79	3	33013468
Pubmed	RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.	GDI1 GDI2	1.53e-05	3	79	2	26240314
Pubmed	The RanBP2/RanGAP1*SUMO1/Ubc9 complex is a multisubunit SUMO E3 ligase.	RANBP2 UBE2I	1.53e-05	3	79	2	22464730
Pubmed	Expression patterns of two human genes coding for different rab GDP-dissociation inhibitors (GDIs), extremely conserved proteins involved in cellular transport.	GDI1 GDI2	1.53e-05	3	79	2	7543319
Pubmed	Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358.	RANBP2 UBE2I	1.53e-05	3	79	2	11709548
Pubmed	Fourier transform ion cyclotron resonance mass spectrometry for the analysis of small ubiquitin-like modifier (SUMO) modification: identification of lysines in RanBP2 and SUMO targeted for modification during the E3 autoSUMOylation reaction.	RANBP2 UBE2I	1.53e-05	3	79	2	16194093
Pubmed	Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle.	GDI1 GDI2	1.53e-05	3	79	2	7513052
Pubmed	Role of Nesprin-2 and RanBP2 in BICD2-associated brain developmental disorders.	BICD2 RANBP2	1.53e-05	3	79	2	36930595
Pubmed	Stability of thioester intermediates in ubiquitin-like modifications.	RANBP2 UBE2I	1.53e-05	3	79	2	19785004
Pubmed	Quantitative analysis of multi-protein interactions using FRET: application to the SUMO pathway.	RANBP2 UBE2I	1.53e-05	3	79	2	18359863
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	RALGDS HECW2 ZNFX1 CHD7 CEP126	2.68e-05	153	79	5	10718198
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	HECW1 HECW2 HUWE1	2.82e-05	26	79	3	26949039
Pubmed	Nucleolar and spindle-associated protein 1 (NUSAP1) interacts with a SUMO E3 ligase complex during chromosome segregation.	RANBP2 UBE2I	3.05e-05	4	79	2	28900032
Pubmed	Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection.	RANBP2 UBE2I	3.05e-05	4	79	2	15608651
Pubmed	Isoform-specific monobody inhibitors of small ubiquitin-related modifiers engineered using structure-guided library design.	RANBP2 UBE2I	3.05e-05	4	79	2	21518904
Pubmed	M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line.	RALGDS RRAS2	3.05e-05	4	79	2	10498616
Pubmed	Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.	MYO5B MYO1B GNAS HUWE1 GDI1 DYNC1H1	3.16e-05	264	79	6	32814769
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	PURA CHCHD6 GNAS GRM2 GDI2 DYNC1H1	4.47e-05	281	79	6	28706196
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	STAM2 SBF1 TFB1M GORAB PSD3 CACHD1 OCRL	4.96e-05	421	79	7	36976175
Pubmed	NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1.	HECW1 HECW2	5.07e-05	5	79	2	14684739
Pubmed	GDI-1 preferably interacts with Rab10 in insulin-stimulated GLUT4 translocation.	GDI1 GDI2	5.07e-05	5	79	2	19570034
Pubmed	Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex.	RANBP2 UBE2I	5.07e-05	5	79	2	15931224
Pubmed	A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors.	RALGDS RRAS2	5.07e-05	5	79	2	35294890
Pubmed	Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry.	BICD2 RANBP2	5.07e-05	5	79	2	20386726
Pubmed	Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport.	GDI1 GDI2	5.07e-05	5	79	2	11929610
Pubmed	The nucleoporin RanBP2 has SUMO1 E3 ligase activity.	RANBP2 UBE2I	5.07e-05	5	79	2	11792325
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	BICD2 CACNA1B CDKL5 RANBP2 HECW1 PURA PSD3 HELZ ZNFX1 EXOC1 HUWE1	5.22e-05	1139	79	11	36417873
Pubmed	HERC5/IFI16/p53 signaling mediates breast cancer cell proliferation and migration.	HECW1 UBE2I HECW2 HUWE1	5.43e-05	90	79	4	35671810
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	CDKL5 SBF1 TFB1M PURA CCDC15 MPC1 OPA3	5.67e-05	430	79	7	32581705
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	RANBP2 ERCC4 LRCH2 SBF1 RBM6 HUWE1 MAP3K4	6.55e-05	440	79	7	34244565
Pubmed	Identification of two independent SUMO-interacting motifs in Fas-associated factor 1 (FAF1): Implications for mineralocorticoid receptor (MR)-mediated transcriptional regulation.	UBE2I FAF1	7.60e-05	6	79	2	30935967
Pubmed	Genome-wide association study of comorbid depressive syndrome and alcohol dependence.	OPA3 FAF1	7.60e-05	6	79	2	22064162
Pubmed	A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region.	BICD2 DYNC1H1	7.60e-05	6	79	2	25272277
Pubmed	β-catenin inhibits promyelocytic leukemia protein tumor suppressor function in colorectal cancer cells.	RANBP2 UBE2I	7.60e-05	6	79	2	22155184
Pubmed	Determinants of small ubiquitin-like modifier 1 (SUMO1) protein specificity, E3 ligase, and SUMO-RanGAP1 binding activities of nucleoporin RanBP2.	RANBP2 UBE2I	7.60e-05	6	79	2	22194619
Pubmed	SUMOylation-disrupting WAS mutation converts WASp from a transcriptional activator to a repressor of NF-κB response genes in T cells.	RANBP2 UBE2I	7.60e-05	6	79	2	26261240
Pubmed	The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function.	GDI1 GDI2	7.60e-05	6	79	2	11809807
Pubmed	Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes.	BICD2 DYNC1H1	7.60e-05	6	79	2	11483508
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	KIF16B CACHD1 ANKRD36 HUWE1	8.52e-05	101	79	4	10997877
Pubmed	Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP.	UBE2I ZNFX1 FAF1	8.99e-05	38	79	3	28680062
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	TRANK1 HECW1 HUWE1 DYNC1H1	9.54e-05	104	79	4	9205841
Pubmed	The N6-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2.	STAM2 DPYSL4 MYO1B HUWE1 GDI1 CRTAP	9.96e-05	325	79	6	36168628
Pubmed	A novel lncRNA MDHDH suppresses glioblastoma multiforme by acting as a scaffold for MDH2 and PSMA1 to regulate NAD+ metabolism and autophagy.	RRAS2 GDI1 GDI2	1.05e-04	40	79	3	36527092
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	CACNA1B CDAN1 RANBP2 TCERG1 PSD3 CHCHD6 GDI2	1.05e-04	475	79	7	31040226
Pubmed	Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation.	RALGDS RRAS2	1.06e-04	7	79	2	11788587
Pubmed	The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signaling axis.	RANBP2 UBE2I	1.06e-04	7	79	2	33649538
Pubmed	Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex.	RANBP2 UBE2I	1.06e-04	7	79	2	12192048
Pubmed	RanGAP1*SUMO1 is phosphorylated at the onset of mitosis and remains associated with RanBP2 upon NPC disassembly.	RANBP2 UBE2I	1.06e-04	7	79	2	15037602
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	STAM2 ERCC4 UBE2I CHCHD6 OPA3 HUWE1 FAF1	1.14e-04	481	79	7	28190767
Pubmed	A human MAP kinase interactome.	INTS6L RALGDS RANBP2 UBE2I TCERG1 HELZ MAP3K4	1.21e-04	486	79	7	20936779
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	SBF1 TFB1M HECW2 RBM6 HELZ	1.25e-04	212	79	5	33853758
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	KIF18A STAM2 RANBP2 SBF1 MYO5B PSD3 HELZ MYO1B CACHD1 HUWE1	1.31e-04	1049	79	10	27880917
Pubmed	Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.	CACNA1B CACNA1F	1.41e-04	8	79	2	28330839
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	RANBP2 LRCH2 SBF1 TCERG1 RBM6 DPYSL4 MYO1B CHD7 INTS8 DYNC1H1	1.68e-04	1082	79	10	38697112
Pubmed	Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling.	RNF144A HUWE1	1.82e-04	9	79	2	28943312
Pubmed	The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf.	RALGDS RRAS2	1.82e-04	9	79	2	10783161
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1B CACNA1F	1.82e-04	9	79	2	16382099
Pubmed	An acetylation switch regulates SUMO-dependent protein interaction networks.	RANBP2 UBE2I	1.82e-04	9	79	2	22578841
Pubmed	Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.	RANBP2 UBE2I	1.82e-04	9	79	2	28877029
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	UNC119 KIF18A LRCH2 MYO5B CDADC1 HELZ CHCHD6 EXOC1 OCRL GDI1 DYNC1H1	1.93e-04	1321	79	11	27173435
Pubmed	Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.	RANBP2 HUWE1 IFIT2 DYNC1H1 CRTAP	2.03e-04	235	79	5	28378594
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RALGDS TRANK1 SBF1 HECW2 KIF16B CACHD1 CEP126	2.04e-04	529	79	7	14621295
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	STAM2 RANBP2 TCERG1 PSD3 MYO1B CACHD1 OCRL DYNC1H1	2.07e-04	708	79	8	39231216
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	RANBP2 LRCH2 OCRL GNAS HUWE1 GDI2 DYNC1H1	2.16e-04	534	79	7	35032548
Pubmed	Dynein and kinesin regulate stress-granule and P-body dynamics.	BICD2 DYNC1H1	2.27e-04	10	79	2	19825938
Pubmed	RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin.	RANBP2 UBE2I	2.27e-04	10	79	2	18946085
Pubmed	The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.	RANBP2 UBE2I	2.27e-04	10	79	2	27160050
Pubmed	The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3.	UNC119 PURA DPYSL4 MYO1B GDI1 GDI2 DYNC1H1	2.64e-04	552	79	7	36293380
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	RANBP2 UBE2I TCERG1 MYO1B GNAS HUWE1 GDI1 GDI2 DYNC1H1 FAF1	2.72e-04	1149	79	10	35446349
Pubmed	NEDL2 is an essential regulator of enteric neural development and GDNF/Ret signaling.	HECW1 HECW2	2.76e-04	11	79	2	25555806
Pubmed	Eml1 loss impairs apical progenitor spindle length and soma shape in the developing cerebral cortex.	KIF18A DYNC1H1	2.76e-04	11	79	2	29229923
Pubmed	T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.	RANBP2 UBE2I	2.76e-04	11	79	2	34110283
Pubmed	Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization.	RALGDS RRAS2	2.76e-04	11	79	2	15031288
Pubmed	The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases.	UNC119 RALGDS	2.76e-04	11	79	2	11786539
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	BICD2 RANBP2 RRAS2 UBE2I CCDC15 CHCHD6 GNAS GDI2 DYNC1H1 CRTAP	2.83e-04	1155	79	10	20360068
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	UTP6 SUMF2 RANBP2 CACHD1 OCRL HUWE1 INTS8 DYNC1H1 FAF1	2.85e-04	942	79	9	31073040
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	BICD2 FHOD3 OCRL GNAS	2.91e-04	139	79	4	25476789
Pubmed	Chromatin accessibility complex subunit 1 enhances tumor growth by regulating the oncogenic transcription of YAP in breast and cervical cancer.	TCERG1 HUWE1 DYNC1H1	3.02e-04	57	79	3	38223760
Pubmed	The DNA sequence of the human X chromosome.	INTS6L CDKL5 CACNA1F LRCH2 OCRL HUWE1	3.35e-04	407	79	6	15772651
Pubmed	BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.	UTP6 SUMF2 ERCC4 TFB1M GXYLT1 CHD7	3.91e-04	419	79	6	33001583
Pubmed	Functional proteomics mapping of a human signaling pathway.	KIF18A STAM2 SUMF2 UBE2I HUWE1 DYNC1H1 FAF1	3.98e-04	591	79	7	15231748
Pubmed	NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner.	HECW1 HECW2	4.55e-04	14	79	2	27119228
Pubmed	Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types.	MYO5B MYO1B	4.55e-04	14	79	2	8022818
Pubmed	BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures.	BICD2 DYNC1H1	4.55e-04	14	79	2	22956769
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	STAM2 SUMF2 GORAB RBM6 CACHD1 OCRL GDI1 GDI2 CRTAP	4.63e-04	1007	79	9	34597346
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	STAM2 HECW1 UBE2I MYO5B NTAQ1 TEP1 GDI1	4.71e-04	608	79	7	16713569
Pubmed	Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.	CACNA1B CACNA1F	5.25e-04	15	79	2	20188150
Pubmed	TRIM28 functions as the SUMO E3 ligase for PCNA in prevention of transcription induced DNA breaks.	RANBP2 UBE2I	5.25e-04	15	79	2	32900933
GeneFamily	UPF1 like RNA helicases	HELZ ZNFX1	4.22e-04	11	51	2	1169
GeneFamily	Integrator complex	INTS6L INTS8	8.00e-04	15	51	2	1366
GeneFamily	Calcium voltage-gated channel subunits	CACNA1B CACNA1F	2.43e-03	26	51	2	253
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	RANBP2 TRANK1 IFIT2	4.18e-03	115	51	3	769
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	HECW1 HECW2	4.62e-03	36	51	2	823
GeneFamily	Ankyrin repeat domain containing	TRANK1 ANKRD11 ANKRD36 ANKRD36C	4.78e-03	242	51	4	403
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF18A KIF16B	7.46e-03	46	51	2	622
CoexpressionAtlas	FacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3	KIF18A RANBP2 TCERG1 MYO5B ANKRD11 RBM6 FHOD3 CHD7 CEP126 MAP3K4	2.45e-05	532	78	10	Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	RANBP2 ANKRD11 ANKRD36 HUWE1 ANKRD36C DYNC1H1	1.06e-06	188	79	6	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Cbln4_Fezf2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CFAP58 MYO1B FHOD3 GRM2 ANO3	9.74e-06	160	79	5	d8241404d775f9a709abdf17988f36293fcf4c58
ToppCell	Cerebellum-Neuronal\|Cerebellum / BrainAtlas - Mouse McCarroll V32	TRANK1 HECW1 PURA FHOD3 GDI1	2.07e-05	187	79	5	61b9d6eb131a674598aa8409d7fa909c8765442d
ToppCell	facs-Skin-Anagen-3m-Epithelial\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BICD2 RALGDS PURA GNAS GDI2	2.23e-05	190	79	5	888ded899f0513d41bf655896d59ae8ef74e0978
ToppCell	facs-Skin-Anagen-3m\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BICD2 RALGDS PURA GNAS GDI2	2.23e-05	190	79	5	3466cebab16964e94da130d0673fa32e7d90b5ed
ToppCell	Entopeduncular-Neuronal\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	CACNA1B TRANK1 HECW1 PURA FHOD3	2.34e-05	192	79	5	4c35e5c28a40b439044797ba1f06cb7c36b2a8de
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1B TRANK1 HECW1 GRM2 ANO3	2.52e-05	195	79	5	ffbab350e67d9c4b66c0ab84550daec8b8139a27
ToppCell	CV-Moderate-6\|CV / Virus stimulation, Condition and Cluster	RRAS2 LAIR2 ANKRD11 GNAS HUWE1	2.59e-05	196	79	5	7bced0cc2112697593c478fa291b8ed3941fb811
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	CDKL5 CACNA1F MYO5B MYO1B CHD7	2.78e-05	199	79	5	d43c605a4ff221cf78d91678c15d2ad20f831c7f
Drug	Capsaicin [404-86-4]; Down 200; 13uM; PC3; HT_HG-U133A	STAM2 SIGLEC8 HELZ MYO1B GNAS TEP1 IFIT2	4.64e-06	194	78	7	4612_DN
Drug	Sotalol hydrochloride [959-24-0]; Up 200; 13uM; MCF7; HT_HG-U133A	STAM2 SBF1 PSD3 CDADC1 DPYSL4 MYO1B OPA3	4.96e-06	196	78	7	7338_UP
Drug	Oxalamine citrate salt [1949-20-8]; Down 200; 9.2uM; HL60; HT_HG-U133A	RALGDS STAM2 SBF1 SIGLEC8 PSD3 OPA3 TEP1	5.13e-06	197	78	7	3006_DN
Disease	Mental Retardation, X-Linked Nonsyndromic	HUWE1 GDI1	5.28e-04	13	78	2	C3501611
Disease	Amphetamine-Related Disorders	MYO5B PSD3 GRM2	1.05e-03	75	78	3	C0236733
Disease	Amphetamine Abuse	MYO5B PSD3 GRM2	1.05e-03	75	78	3	C0236807
Disease	Amphetamine Addiction	MYO5B PSD3 GRM2	1.05e-03	75	78	3	C0236804
Disease	Epilepsy, Cryptogenic	CDKL5 PURA ANKRD11	1.35e-03	82	78	3	C0086237
Disease	Awakening Epilepsy	CDKL5 PURA ANKRD11	1.35e-03	82	78	3	C0751111
Disease	Aura	CDKL5 PURA ANKRD11	1.35e-03	82	78	3	C0236018
Disease	Arthrogryposis	BICD2 DYNC1H1	1.40e-03	21	78	2	C0003886
Disease	Ovarian Serous Adenocarcinoma	CDKL5 MAP3K4	1.68e-03	23	78	2	C1335177
Disease	Neurodevelopmental Disorders	CDKL5 PURA ANKRD11	1.94e-03	93	78	3	C1535926
Disease	response to perphenazine	RNF144A FHOD3	2.15e-03	26	78	2	GO_0097334
Disease	Micronuclei, Chromosome-Defective	ERCC4 NFE2L2	2.15e-03	26	78	2	C1449861
Disease	Micronuclei, Genotoxicant-Induced	ERCC4 NFE2L2	2.15e-03	26	78	2	C1449862

Protein segments in the cluster

Peptide	Gene	Start	Entry
EKRDYREPFFRKKDR	ANKRD11	896	Q6UB99
GRLRDDIKEYKFREA	BICD2	161	Q8TD16
RRLYKDFVLNVKFDA	GRM2	416	Q14416
IEFRHKRKVFEQGYR	GSG1L	246	Q6UXU4
KIREKFNRYLDVVNR	CACHD1	91	Q5VU97
KNRVIFDLIYEYERK	ANKRD36	241	A6QL64
KDREIRKFRYIIHAE	CDADC1	386	Q9BWV3
DKYHFRIFRVLKVQR	CST11	61	Q9H112
FVFSEDNVVRKYAKR	CACNA1B	76	Q00975
SRQVKRKRYTEDLEF	CHD7	751	Q9P2D1
TFKKQRDVFYEVLRE	CDAN1	451	Q8IWY9
YDRSRLINDFVIKDK	ANO3	121	Q9BYT9
RKRFDRAEAEYIAAK	GORAB	221	Q5T7V8
EELEKAQLRFFEFKR	KIF16B	816	Q96L93
VRKAADYVRSKDFRD	MPC1	6	Q9Y5U8
DEKVLYSQRVKLFRF	RANBP2	2031	P49792
FVEFTIKEAARFKRR	INTS6L	816	Q5JSJ4
YENAREKFFRTKELI	INTS8	271	Q75QN2
KNRVIFELIYEYERK	ANKRD36C	241	Q5JPF3
RDFEAKLRNFYRKLE	HECW2	1191	Q9P2P5
TFLIQDYFRKFRRRK	CACNA1F	1586	O60840
EKRRFRKFLVYVANF	GDI2	136	P50395
DFEAKLRNFYRKLEA	HECW1	1226	Q76N89
RSYLEKRREEELKQF	KIF18A	491	Q8NI77
QRKIIFHLEKERDRY	CFAP58	431	Q5T655
AELEEKRRYRFLAEK	BAIAP2L2	176	Q6UXY1
VYAVRKQLRKFVERE	CARF	436	Q8N187
RIKEAARRSEFFKTY	OPA3	26	Q9H6K4
VFDFSQRRKEYELEK	NFE2L2	36	Q16236
FIKQLAKSVRDRYAR	GXYLT1	421	Q4G148
YADQVFRIRAELRKK	HELZ	956	P42694
VLDFDVKRKYFRQEL	HUWE1	3991	Q7Z6Z7
VKRKYFRQELERLDE	HUWE1	3996	Q7Z6Z7
QRYKKLQFEREVLFD	RNF144A	91	P50876
EKAFFDVKTTRRVYN	SBF1	1831	O95248
FFRRRYKEIIEAEKN	ITGA9	1006	Q13797
DFVYKRIKARNRLAE	DPYSL4	476	O14531
ARKYFVESNRRKKAF	CEP126	71	Q9P2H0
REVLADFQRREPYKF	CRTAP	136	O75718
QRIEREERNKFRYKY	FHOD3	471	Q2V2M9
VVREKLRKYVFDRVN	CCDC183	91	Q5T5S1
YGRLINFEKRRKEFE	RALGDS	586	Q12967
DKVFYRTEFQNREFK	IFIT2	36	P09913
QEELRDYVKARLKVF	DYNC1H1	2886	Q14204
DQFVRIYDQRRIDKK	DCAF8L1	356	A6NGE4
RLYEREIKDFFEVAK	EXOC1	416	Q9NV70
EKRRFRKFLVFVANF	GDI1	136	P31150
FQEAFYVKARDRKLL	FAF1	361	Q9UNN5
KEAFRRRGKLYLVFE	CDKL5	76	O76039
FRRKFRVIRADSYLK	NTAQ1	126	Q96HA8
QTFRLEREDRAKYKD	LAIR2	56	Q6ISS4
EERRRSKQIRKEYFK	LRCH2	551	Q5VUJ6
AIQKSVRLFEEKRYR	MAP3K4	1296	Q9Y6R4
EYKIQRRTLFKEDFI	UTP6	41	Q9NYH9
ELAYLERREREGKFK	RBM6	996	P78332
NKDFRDFVREKKYRT	SUMF2	71	Q8NBJ7
RDTFYKEQLERIERK	CHCHD6	151	Q9BRQ6
RVTRAKYFIRDEFLR	GNAS	976	Q5JWF2
FEEIYKFQRQILRVK	RRAS2	101	P62070
IRDARKRDKGSYFFR	SIGLEC8	111	Q9NYZ4
QLFAYNFREELKRRK	TFB1M	316	Q8WVM0
KRLRKALREFEEQFF	FAM13C	526	Q8NE31
KVVDERRYRKVFEDS	OCRL	536	Q01968
REKQQREKEYLRYVE	CCDC15	851	Q0P6D6
EVQKDAQYRFEFFRK	CNBD2	226	Q96M20
ERFCNREREFVYKFK	C12orf4	6	Q9NQ89
ENIYKIDFVRFKIRD	UNC119	81	Q13432
RVEYEKRVRAQAKKF	UBE2I	141	P63279
RYIGFLREEQRKFEK	TEP1	411	Q99973
SDRKKQREFEEYIRD	TCERG1	996	O14776
REDSFQKVILRRYEK	ZNF728	91	P0DKX0
NKVARKVRALYDFEA	STAM2	201	O75886
RKRKFDDIRIYFDTR	ZNFX1	401	Q9P2E3
EILRKFLYLEREFRQ	ZNF655	101	Q8N720
EQRYLTALRKEKEAF	ERCC4	616	Q92889
REKRAPAFKYFIRRD	TRANK1	1661	O15050
RLYQLDRFKRSDVAK	PSD3	591	Q9NYI0
RALKSEFLVRENRKY	PURA	141	Q00577
EDKRRVKERLFQCYR	TTLL13	431	A6NNM8
LKVRREYRKFFRANA	MYO1B	851	O43795
HDFFNRYRVLVKKRE	MYO5B	701	Q9ULV0