Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzodiazepine receptor binding	RIMBP3 RIMBP3C RIMBP3B	2.26e-06	5	123	3	GO:0030156
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	IQSEC3 RAPGEF5 OBSCN ALS2 CHML RGS12 NF1 ARAP3 SBF1 PLCG1 HERC2 MCF2L	7.06e-05	507	123	12	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	IQSEC3 RAPGEF5 OBSCN ALS2 CHML RGS12 NF1 ARAP3 SBF1 PLCG1 HERC2 MCF2L	7.06e-05	507	123	12	GO:0030695
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	IQSEC3 RAPGEF5 OBSCN ALS2 SBF1 PLCG1 HERC2 MCF2L	9.34e-05	231	123	8	GO:0005085
GeneOntologyMolecularFunction	quaternary ammonium group binding	TKTL2 ESYT3 NF1 IGHM	1.83e-04	46	123	4	GO:0050997
GeneOntologyBiologicalProcess	observational learning	SHANK3 NF1 HTT	1.46e-05	9	117	3	GO:0098597
MousePheno	ectopic manchette	IQCN RIMBP3 RIMBP3C RIMBP3B	6.88e-06	19	94	4	MP:0009377
Domain	SH3_domain	NCKIPSD OBSCN SHANK3 RIMBP3 MIA2 RIMBP3C PLCG1 MCF2L RIMBP3B	1.25e-05	220	120	9	IPR001452
Domain	SH3_2	SHANK3 RIMBP3 MIA2 RIMBP3C MCF2L RIMBP3B	1.92e-05	86	120	6	PF07653
Domain	SH3_2	SHANK3 RIMBP3 MIA2 RIMBP3C MCF2L RIMBP3B	1.92e-05	86	120	6	IPR011511
Domain	-	IQSEC3 OBSCN APBB1 ALS2 RGS12 GAB2 SPTBN5 ARAP3 SBF1 PLCG1 MCF2L	4.44e-05	391	120	11	2.30.29.30
Domain	SH3	NCKIPSD OBSCN SHANK3 RIMBP3 RIMBP3C PLCG1 MCF2L RIMBP3B	7.79e-05	216	120	8	SM00326
Domain	SH3	NCKIPSD OBSCN SHANK3 RIMBP3 RIMBP3C PLCG1 MCF2L RIMBP3B	7.79e-05	216	120	8	PS50002
Domain	PH	IQSEC3 OBSCN ALS2 GAB2 SPTBN5 ARAP3 SBF1 PLCG1 MCF2L	7.80e-05	278	120	9	SM00233
Domain	PH_DOMAIN	IQSEC3 OBSCN ALS2 GAB2 SPTBN5 ARAP3 SBF1 PLCG1 MCF2L	8.02e-05	279	120	9	PS50003
Domain	PH_domain	IQSEC3 OBSCN ALS2 GAB2 SPTBN5 ARAP3 SBF1 PLCG1 MCF2L	8.24e-05	280	120	9	IPR001849
Domain	PH_dom-like	IQSEC3 OBSCN APBB1 ALS2 RGS12 GAB2 SPTBN5 ARAP3 SBF1 PLCG1 MCF2L	9.55e-05	426	120	11	IPR011993
Domain	RCC1	ALS2 HERC2 HERC6	2.72e-04	20	120	3	PF00415
Domain	FN3	NPHS1 CRLF1 OBSCN RIMBP3 RIMBP3C RIMBP3B HCFC1	3.02e-04	199	120	7	PS50853
Domain	RCC1_1	ALS2 HERC2 HERC6	3.16e-04	21	120	3	PS00625
Domain	RCC1_2	ALS2 HERC2 HERC6	3.16e-04	21	120	3	PS00626
Domain	RCC1_3	ALS2 HERC2 HERC6	3.16e-04	21	120	3	PS50012
Domain	-	ALS2 HERC2 HERC6	3.64e-04	22	120	3	2.130.10.30
Domain	Reg_chr_condens	ALS2 HERC2 HERC6	3.64e-04	22	120	3	IPR000408
Domain	FN3_dom	NPHS1 CRLF1 OBSCN RIMBP3 RIMBP3C RIMBP3B HCFC1	4.06e-04	209	120	7	IPR003961
Domain	RCC1/BLIP-II	ALS2 HERC2 HERC6	4.17e-04	23	120	3	IPR009091
Domain	PH	OBSCN GAB2 SPTBN5 ARAP3 SBF1 PLCG1 MCF2L	7.00e-04	229	120	7	PF00169
Pubmed	RIM-BP3 is a manchette-associated protein essential for spermiogenesis.	RIMBP3 RIMBP3C RIMBP3B	1.76e-07	4	124	3	19091768
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ACACA KHNYN OBSCN AMBRA1 SRCAP NBPF1 RHPN1 ARAP3 SBF1 XPO6 ANKRD11 NAV2 PLCG1 HERC2 MCF2L HCFC1 HTT	4.29e-07	1105	124	17	35748872
Pubmed	Structure and evolution of RIM-BP genes: identification of a novel family member.	RIMBP3 RIMBP3C RIMBP3B	4.40e-07	5	124	3	17855024
Pubmed	High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.	POLR2B LAMC2 PKP3 ATIC CPSF3 HCFC1 TOP1 EIF3M HSD17B8 RPL15	7.50e-06	469	124	10	37314180
Pubmed	Association study of the CNS patterning genes and autism in Han Chinese in Taiwan.	WNT2 SHANK3	1.26e-05	2	124	2	21575668
Pubmed	Undetectable histone O-GlcNAcylation in mammalian cells.	TET2 HCFC1	1.26e-05	2	124	2	26075789
Pubmed	Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-{gamma}1.	NPHS1 PLCG1	1.26e-05	2	124	2	19179337
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TET2 COG2 CAND1 BACH1 APBB1 STAB1 EFEMP1 MIA2 TNKS ATIC PLCG1 ZNF841 HERC2 ST18 TOP1 RPL15	1.41e-05	1285	124	16	35914814
Pubmed	Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.	RIMBP3 RIMBP3C RIMBP3B	1.56e-05	14	124	3	17662146
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	CAND1 ACACA POLR2B AMBRA1 SRCAP NF1 ARAP3 SBF1 ATIC PLCG1 HERC2 CPSF3 TOP1 EIF3M ALDH7A1 RPL15	2.63e-05	1353	124	16	29467282
Pubmed	The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.	ANKRD11 TNKS HERC2	2.90e-05	17	124	3	23502783
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	KHNYN SRCAP XPO6 HERC2 MCF2L	3.68e-05	104	124	5	9205841
Pubmed	Topoisomerase 1 inhibitor topotecan delays the disease progression in a mouse model of Huntington's disease.	TOP1 HTT	3.77e-05	3	124	2	28007908
Pubmed	CARD19, a Novel Regulator of the TAK1/NF-κB Pathway in Self-Reactive B Cells.	CARD19 IGHM	3.77e-05	3	124	2	36961449
Pubmed	NEURL4 regulates the transcriptional activity of tumor suppressor protein p53 by modulating its oligomerization.	HERC2 NEURL4	3.77e-05	3	124	2	28977907
Pubmed	ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases.	ADAMTSL1 ADAMTSL2	3.77e-05	3	124	2	14667842
Pubmed	Mutant huntingtin interacts with the sterol regulatory element-binding proteins and impairs their nuclear import.	SREBF2 HTT	3.77e-05	3	124	2	31875875
Pubmed	Acetyl-CoA carboxylase and SREBP expression during peripheral nervous system myelination.	ACACA SREBF2	3.77e-05	3	124	2	12668174
Pubmed	Receptors for polytropic and xenotropic mouse leukaemia viruses encoded by a single gene at Rmc1.	LAMC2 XPR1	3.77e-05	3	124	2	9988277
Pubmed	DNA hypermethylation is associated with invasive phenotype of malignant melanoma.	TET2 NAV2	3.77e-05	3	124	2	31602702
Pubmed	Attenuation of PI3K/Akt-mediated tumorigenic signals through PTEN activation by DNA vaccine-induced anti-ErbB2 antibodies.	PRF1 IGHM	3.77e-05	3	124	2	20220087
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	TET2 ACACA BACH1 NCKIPSD APBB1 ALS2 RGS12 GAB2 NF1 SBF1 ANKRD11 NAV2	6.20e-05	861	124	12	36931259
Pubmed	NuMorph: Tools for cortical cellular phenotyping in tissue-cleared whole-brain images.	NF1 TOP1	7.53e-05	4	124	2	34644582
Pubmed	Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells.	TET2 HCFC1	7.53e-05	4	124	2	23352454
Pubmed	CD8+ T cell-independent tumor regression induced by Fc-OX40L and therapeutic vaccination in a mouse model of glioma.	PRF1 IGHM	7.53e-05	4	124	2	24293627
Pubmed	TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS.	TET2 HCFC1	7.53e-05	4	124	2	23353889
Pubmed	The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination.	PRF1 IGHM	7.53e-05	4	124	2	18469826
Pubmed	Regulation of the MDM2-p53 pathway by the ubiquitin ligase HERC2.	HERC2 NEURL4	7.53e-05	4	124	2	31665549
Pubmed	An integrated somatic cell hybrid, YAC, and BAC map of the Rmc1 region of mouse chromosome 1.	LAMC2 XPR1	7.53e-05	4	124	2	10373331
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	ACACA POLR2B BACH1 OBSCN RGS12 CROCC2 ANKRD11 NAV2 HCFC1	7.68e-05	497	124	9	36774506
Pubmed	Cloning and characterization of a cell surface receptor for xenotropic and polytropic murine leukemia viruses.	LAMC2 XPR1	1.25e-04	5	124	2	9927670
Pubmed	Perforin and Fas cytolytic pathways coordinately shape the selection and diversity of CD8+-T-cell escape variants of influenza virus.	PRF1 IGHM	1.25e-04	5	124	2	15956596
Pubmed	Coupling and uncoupling of tumor immunity and autoimmunity.	PRF1 IGHM	1.25e-04	5	124	2	10587362
Pubmed	HERC2 Facilitates BLM and WRN Helicase Complex Interaction with RPA to Suppress G-Quadruplex DNA.	HERC2 NEURL4 EIF3M	1.85e-04	31	124	3	30279242
Pubmed	Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture.	CAND1 HERC2 NEURL4	1.85e-04	31	124	3	22261722
Pubmed	Effector CD8 T Cell-Dependent Zika Virus Control in the CNS: A Matter of Time and Numbers.	PRF1 IGHM	1.87e-04	6	124	2	32973802
Pubmed	Perforin- and granzyme-mediated cytotoxic effector functions are essential for protection against Francisella tularensis following vaccination by the defined F. tularensis subsp. novicida ΔfopC vaccine strain.	PRF1 IGHM	1.87e-04	6	124	2	22493083
Pubmed	Tet2 and Tet3 in B cells are required to repress CD86 and prevent autoimmunity.	TET2 IGHM	1.87e-04	6	124	2	32572241
Pubmed	Pivotal role of antibody and subsidiary contribution of CD8+ T cells to recovery from infection in a murine model of Japanese encephalitis.	PRF1 IGHM	1.87e-04	6	124	2	21450826
Pubmed	Immune-mediated protection from measles virus-induced central nervous system disease is noncytolytic and gamma interferon dependent.	PRF1 IGHM	2.62e-04	7	124	2	11932415
Pubmed	Association of signaling proteins with a nonmitogenic heterodimeric complex composed of epidermal growth factor receptor and kinase-inactive p185c-neu.	RAPGEF5 PLCG1	2.62e-04	7	124	2	8561895
Pubmed	Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1.	GAB2 PLCG1	2.62e-04	7	124	2	10391903
Pubmed	TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis.	TET2 IGHM	2.62e-04	7	124	2	30274972
Pubmed	CD4+ T cells require either B cells or CD8+ T cells to control spread and pathogenesis of a neurotropic infection.	PRF1 IGHM	2.62e-04	7	124	2	27677156
Pubmed	Regulator of G protein signaling 12 drives inflammatory arthritis by activating synovial fibroblasts through MYCBP2/KIF2A signaling.	RGS12 HERC2	2.62e-04	7	124	2	36700049
Pubmed	Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins.	ACACA SBF1 HERC2	4.27e-04	41	124	3	19343720
Pubmed	B-cells and IL-4 promote methylcholanthrene-induced carcinogenesis but there is no evidence for a role of T/NKT-cells and their effector molecules (Fas-ligand, TNF-α, perforin).	PRF1 IGHM	4.47e-04	9	124	2	22212899
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	TET2 OBSCN ALS2 KIAA1586	4.81e-04	101	124	4	10997877
Pubmed	Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.	CAND1 POLR2B TOP1	4.92e-04	43	124	3	26030138
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	RAPGEF5 POLR2B OBSCN SREBF2 ALS2 SRCAP ZRANB3 ZSCAN10 ZNF32 GLG1 PLCG1 RPL15	5.13e-04	1084	124	12	11544199
Pubmed	Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes.	POLR2B HCFC1	5.57e-04	10	124	2	17998332
Pubmed	Protective immunity against secondary poxvirus infection is dependent on antibody but not on CD4 or CD8 T-cell function.	PRF1 IGHM	5.57e-04	10	124	2	16775321
Pubmed	The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway.	HERC2 NEURL4	5.57e-04	10	124	2	26355680
Pubmed	RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain.	HERC2 NEURL4	5.57e-04	10	124	2	29097665
Pubmed	Immune effectors required for hepatitis B virus clearance.	PRF1 IGHM	5.57e-04	10	124	2	20080755
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	ADAMTSL1 GAB2 ST18 ADAMTSL2	5.57e-04	105	124	4	9628581
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	ACACA NF1 SBF1 ATIC HERC2 CPSF3 HCFC1 TOP1 RPL15	5.74e-04	653	124	9	22586326
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	IQSEC3 RAPGEF5 KHNYN ALS2 SLIT1 MCF2L ST18	6.65e-04	407	124	7	12693553
Pubmed	CTLA-4 blockade induces a microglia-Th1 cell partnership that stimulates microglia phagocytosis and anti-tumor function in glioblastoma.	IGHM SIGLEC1	6.79e-04	11	124	2	37572655
Pubmed	Bacterial inhibition of Fas-mediated killing promotes neuroinvasion and persistence.	PRF1 IGHM	6.79e-04	11	124	2	35296858
Pubmed	Hundreds of variants clustered in genomic loci and biological pathways affect human height.	TET2 ZNF142 POLR2B SMIM23 EFEMP1	7.40e-04	198	124	5	20881960
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	ACACA ARAP3 SBF1 HERC2 NEURL4	8.10e-04	202	124	5	33005030
Pubmed	ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease.	IQSEC3 SHANK3 ATIC ALDH7A1 HTT	8.10e-04	202	124	5	33601422
Pubmed	WT1 targets Gas1 to maintain nephron progenitor cells by modulating FGF signals.	NPHS1 CRLF1	8.13e-04	12	124	2	25804736
Pubmed	Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population.	GRIK4 RFX4 MPPE1	8.61e-04	52	124	3	19328558
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CAND1 ACACA OBSCN SREBF2 IQCN NBPF1 SHISA9 RANBP17 PKP3 ANKRD11 PLCG1 MCF2L EIF3M HTT	8.78e-04	1489	124	14	28611215
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	APBB1 TNKS PLCG1 HERC2	9.19e-04	120	124	4	31413325
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	COG2 CAND1 ACACA POLR2B SREBF2 KATNA1 NF1 KMT5B ANKRD11 ATIC PLCG1 EIF3M HTT	9.32e-04	1327	124	13	32694731
Pubmed	Nucleotide sequence of mouse spermidine synthase cDNA.	ACACA SREBF2	9.59e-04	13	124	2	7803821
Pubmed	Establishment of fetomaternal tolerance through glycan-mediated B cell suppression.	IGHM SIGLEC1	9.59e-04	13	124	2	35236989
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	ACACA POLR2B AMBRA1 SRCAP NF1 SBF1 HERC2	1.05e-03	440	124	7	34244565
Pubmed	Ischemic stroke is associated with the ABO locus: the EuroCLOT study.	ABO MCF2L	1.12e-03	14	124	2	23381943
Pubmed	A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.	SREBF2 HCFC1	1.12e-03	14	124	2	10976766
Pubmed	LZTR1 is a regulator of RAS ubiquitination and signaling.	GAB2 NF1 SBF1 PKP3	1.13e-03	127	124	4	30442766
Pubmed	Mapping of quantitative trait loci determining NK cell-mediated resistance to MHC class I-deficient bone marrow grafts in perforin-deficient mice.	PRF1 PLCG1	1.28e-03	15	124	2	17114464
Pubmed	TRIM28 functions as the SUMO E3 ligase for PCNA in prevention of transcription induced DNA breaks.	POLR2B TOP1	1.28e-03	15	124	2	32900933
Pubmed	Tat predominantly associates with host promoter elements in HIV-1-infected T-cells - regulatory basis of transcriptional repression of c-Rel.	WNT2 HCFC1	1.28e-03	15	124	2	25472883
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	ALS2 STAB1 XPO6 SLIT1 NAV2	1.31e-03	225	124	5	12168954
Pubmed	Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.	ACACA RAPGEF5 OBSCN KIAA1586 ZRANB3	1.33e-03	226	124	5	31452512
Pubmed	Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels.	PIF1 HTT	1.46e-03	16	124	2	27721240
Pubmed	Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.	ACACA SREBF2	1.46e-03	16	124	2	8833906
Pubmed	Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas.	PRF1 IGHM	1.46e-03	16	124	2	24487434
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	NF1 SLIT1 TNKS HERC2 MCF2L TOP1 HTT	1.62e-03	475	124	7	31040226
Pubmed	Movement-related increases in subthalamic activity optimize locomotion.	NLRP12 HTT	1.66e-03	17	124	2	39068661
Pubmed	EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes.	TOP1 RPL15	1.86e-03	18	124	2	15064750
Pubmed	Mutation specific functions of EGFR result in a mutation-specific downstream pathway activation.	NF1 PKP3 PLCG1	1.87e-03	68	124	3	25754235
Pubmed	Biological, clinical and population relevance of 95 loci for blood lipids.	ABO LILRB2 KHNYN TOP1	1.89e-03	146	124	4	20686565
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	CAND1 ACACA APBB1 SRCAP ATIC PLCG1 CPSF3 HCFC1 TOP1 RPL15	1.93e-03	934	124	10	33916271
Pubmed	Multifaceted Regulation of Akt by Diverse C-Terminal Post-translational Modifications.	NCKIPSD AMBRA1 GAB2	1.95e-03	69	124	3	34941261
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	ACACA POLR2B ALS2 SRCAP TOP1 MOCS1	1.97e-03	363	124	6	14691545
Pubmed	SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression.	ACACA SREBF2	2.07e-03	19	124	2	26685326
Pubmed	TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.	AMBRA1 TRIM17	2.30e-03	20	124	2	25127057
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	CAND1 ACACA POLR2B EFEMP1 GLG1 PKP3 CPSF3 HCFC1 TOP1 EIF3M HSD17B8 ALDH7A1	2.36e-03	1297	124	12	33545068
Pubmed	UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.	ATIC HERC2	2.53e-03	21	124	2	37422473
Pubmed	Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).	ACACA SREBF2	2.78e-03	22	124	2	20965718
Pubmed	Insights into the ubiquitin-proteasome system of human embryonic stem cells.	ZSCAN10 ANKRD11 HERC2 NEURL4 TOP1	2.84e-03	269	124	5	29511261
Pubmed	Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.	ACACA SREBF2	3.04e-03	23	124	2	26508642
Pubmed	Detection of genes regulated by Lmx1b during limb dorsalization.	RFX4 EFEMP1	3.04e-03	23	124	2	22417325
Pubmed	ATP-citrate lyase deficiency in the mouse.	ACACA SREBF2	3.04e-03	23	124	2	14662765
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	ADAMTSL1 LAMC2 EFEMP1 HCFC1	3.08e-03	167	124	4	22159717
Cytoband	Ensembl 112 genes in cytogenetic band chr20q12	EMILIN3 PLCG1 TOP1	4.78e-05	26	124	3	chr20q12
Cytoband	20q12-q13.1	PLCG1 TOP1	3.21e-04	10	124	2	20q12-q13.1
GeneFamily	ADAMTS like	ADAMTSL1 ADAMTSL2	4.00e-04	7	80	2	947
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF142 ZNF555 ZNF77 ZNF594 ZSCAN10 ZNF32 PRDM12 ZNF808 ZNF841 ZNF433	1.23e-03	718	80	10	28
GeneFamily	ATAC complex	ZZZ3 HCFC1	1.46e-03	13	80	2	1058
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	GAB2 ARAP3 SBF1 PLCG1 MCF2L	2.20e-03	206	80	5	682
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	ZZZ3 HERC2	2.83e-03	18	80	2	91
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	OBSCN ALS2 MCF2L	3.12e-03	66	80	3	722
ToppCell	COPD-Epithelial-ATII\|Epithelial / Disease state, Lineage and Cell class	PDE4C RAPGEF5 IQCN GAB2 ESYT3 AGBL1 TOP1	9.57e-07	187	124	7	030af361f8bdcd0aff4ec1922702833325cf74d8
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	ACACA AMBRA1 GAB2 RANBP17 NF1 NAV2 AGBL1	1.40e-06	198	124	7	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ACACA RAPGEF5 EFEMP1 NAV2 AGBL1 XPR1	3.71e-06	148	124	6	9fe3c0a5904b8e9a0f28130f8d84d4f2a819b06c
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ACACA RAPGEF5 RANBP17 EFEMP1 NAV2 AGBL1	1.18e-05	181	124	6	576da14ab3107f89e1f44a4a439d1bef5bb42370
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TET2 LILRB2 BACH1 CHML JMY STAB1	1.29e-05	184	124	6	b45b1fdba13c8ed2a04a4fb3b62d8ad92785c768
ToppCell	facs-Lung-nan-3m-Endothelial-endothelial_cell_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAPGEF5 SHANK3 STAB1 ARAP3 PLCG1 MCF2L	1.74e-05	194	124	6	f159ef8541d75a4e98468947f231bb463bec922c
ToppCell	COVID-19-lung-Macrophage_CD163hi_MERTKhi\|lung / Disease (COVID-19 only), tissue and cell type	TET2 LILRB2 BACH1 GAB2 STAB1 SIGLEC1	1.79e-05	195	124	6	148fff8c3c9ba45ec36e98dff1be57e3f8294506
ToppCell	wk_15-18-Epithelial-Distal_epithelial-type_II_pneumocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ADAMTSL1 CRLF1 LAMC2 ESYT3 EFEMP1 PKP3	1.79e-05	195	124	6	0e3aac1b1a1fd483f5fb9a394eb90c0e1ce63542
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TET2 LILRB2 BACH1 JMY STAB1 ST18	1.85e-05	196	124	6	01cea0bb0b938d0986fd2ddae06597b8af1768ee
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TET2 LILRB2 BACH1 JMY STAB1 ST18	1.85e-05	196	124	6	c2bbb48c4aa979b03cb6f4ce9f351f492977c992
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TET2 LILRB2 BACH1 JMY STAB1 ST18	1.85e-05	196	124	6	64c2abc0087bf2ae547932377f3662e3be1cc63e
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	LILRB2 GAB2 STAB1 IGHM SLIT1 SIGLEC1	2.01e-05	199	124	6	b818d46a39c8782188d82dc8931b8eec9d549dd1
ToppCell	Tracheal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ABO ACACA RAPGEF5 SREBF2 RANBP17 MCF2L	2.07e-05	200	124	6	d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW16-Neuronal-Intermediate\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	SHLD1 JMY SBF1 NAV2 CHRNA10 MOSMO	2.07e-05	200	124	6	a3fcd901cb281920f1bafdfd676399a6dc37355e
ToppCell	LA-10._Endothelium_II\|World / Chamber and Cluster_Paper	RAPGEF5 SHANK3 SHISA9 ARAP3 MCF2L	2.96e-05	128	124	5	071becbe97598c2b65580b0989eb664d6fd6c85a
ToppCell	LA-10._Endothelium_II\|LA / Chamber and Cluster_Paper	RAPGEF5 SHANK3 SHISA9 ARAP3 MCF2L	3.68e-05	134	124	5	048fa6ccf305d22d9a53db4ab385f39f558010d8
Drug	Bumetanide [28395-03-1]; Down 200; 11uM; MCF7; HT_HG-U133A	SLC35C2 SREBF2 SRCAP RGS12 MIA2 SBF1 GLG1 PLCG1 HCFC1	1.13e-06	199	120	9	5542_DN
Disease	corpus callosum anterior volume measurement	ADAMTSL1 LAMC2 SMIM23 NAV2	1.51e-05	39	113	4	EFO_0010295
Disease	creatine kinase measurement	ABO LILRB2 BACH1 GAB2	7.89e-05	59	113	4	EFO_0004534
Disease	Manic mood	SHANK3 STAB1	8.68e-05	4	113	2	C0564408
Disease	L lactate dehydrogenase measurement	ABO GAB2 STAB1	1.33e-04	26	113	3	EFO_0004808
Disease	glutamate receptor ionotropic, delta-2 measurement	IGHM SIGLEC1	1.44e-04	5	113	2	EFO_0801631
Disease	Glaucoma	MYOC EFEMP1	2.16e-04	6	113	2	cv:C0017601
Disease	apolipoprotein B measurement	PDE4C ABO MKRN2 SHLD1 RGS12 NF1 LYPD5 PLCG1 TOP1 HTT	2.39e-04	663	113	10	EFO_0004615
Disease	hepatocyte growth factor activator measurement	RGS12 HTT	3.01e-04	7	113	2	EFO_0008152
Disease	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 measurement	NLRP12 EMILIN3	3.01e-04	7	113	2	EFO_0020108
Disease	glaucoma	RAPGEF5 MYOC EFEMP1 HERC2 ST18	3.24e-04	154	113	5	MONDO_0005041
Disease	protein-tyrosine sulfotransferase 2 measurement	NLRP12 ABO	4.01e-04	8	113	2	EFO_0801971
Disease	Disease Exacerbation	SREBF2 LAMC2 TOP1 ALDH7A1 RPL15	4.44e-04	165	113	5	C0235874
Disease	secreted and transmembrane protein 1 measurement	NLRP12 ABO	6.41e-04	10	113	2	EFO_0021852
Disease	membranoproliferative glomerulonephritis (biomarker_via_orthology)	MYOC PRF1	6.41e-04	10	113	2	DOID:2920 (biomarker_via_orthology)
Disease	serum gamma-glutamyl transferase measurement	PDE4C ABO RAPGEF5 BACH1 STAB1 ZZZ3 NF1 NAV2 SIGLEC1 PLCG1 TOP1	7.80e-04	914	113	11	EFO_0004532
Disease	multiple myeloma	SRCAP ANKRD11 TNKS HERC2	9.21e-04	112	113	4	EFO_0001378
Disease	pneumonia, COVID-19	ADAMTSL1 ACACA RFX4 ST18	9.52e-04	113	113	4	EFO_0003106, MONDO_0100096
Disease	tyrosine-protein kinase receptor Tie-1, soluble measurement	ABO ADAMTSL2	1.10e-03	13	113	2	EFO_0008312
Disease	cutaneous melanoma	DOCK8-AS1 RAPGEF5 ANKRD11 HERC2	1.23e-03	121	113	4	EFO_0000389
Disease	CD209 antigen measurement	ABO ADAMTSL2	1.28e-03	14	113	2	EFO_0008077
Disease	cup-to-disc ratio measurement	ADAMTSL1 ABO NCKIPSD EFEMP1 GLG1 CROCC2 NAV2	1.37e-03	430	113	7	EFO_0006939
Disease	thrombomodulin measurement	NPHS1 ABO	1.90e-03	17	113	2	EFO_0007774
Disease	immature granulocyte count	NLRP12 ABO	1.90e-03	17	113	2	EFO_0803542
Disease	hip circumference	MXRA5 ZRANB3 SHISA9 ZZZ3 NF1 GP2	1.96e-03	338	113	6	EFO_0005093
Disease	synophrys measurement	NAV2 HERC2 HTT	2.29e-03	68	113	3	EFO_0007906
Disease	skin sensitivity to sun	ANKRD11 HERC2	2.38e-03	19	113	2	EFO_0004795
Disease	insulin sensitivity measurement, body mass index	AGBL1 GP2	2.38e-03	19	113	2	EFO_0004340, EFO_0004471
Disease	hemorrhoid	TET2 ABO BACH1 NF1	2.50e-03	147	113	4	EFO_0009552
Disease	coagulation factor measurement	ABO MCF2L	2.64e-03	20	113	2	EFO_0004634
Disease	Malignant neoplasm of breast	OBSCN SREBF2 EFEMP1 NF1 ARAP3 MIA2 HERC2 CPSF3 TOP1 EIF3M HSD17B8	2.79e-03	1074	113	11	C0006142
Disease	alcohol consumption measurement	ACACA LAMC2 KATNA1 RGS12 SPTBN5 RANBP17 ZZZ3 NF1 ANKRD11 ST18 AGBL1 HTT	2.90e-03	1242	113	12	EFO_0007878
Disease	Hepatitis	SMIM23 NAV2	3.19e-03	22	113	2	HP_0012115
Disease	intraocular pressure measurement	MXRA5 ABO MYOC GRIK4 GAB2 EFEMP1 HERC2	3.50e-03	509	113	7	EFO_0004695
Disease	partial thromboplastin time	ABO AGBL1	3.80e-03	24	113	2	EFO_0004310
Disease	brain stem volume measurement	KATNA1 RFX4	3.80e-03	24	113	2	EFO_0010605

Protein segments in the cluster

Peptide	Gene	Start	Entry
TIANTFRSHRAAQRC	CHRNA10	401	Q9GZZ6
RVNGVKAHTNTCNRR	ESYT3	171	A0FGR9
EGQRFRAHRSVLAAC	BACH1	41	O14867
ESRGVCQGRAEHRLS	ARAP3	221	Q8WWN8
AARRGHVECVNSLIA	ASB9	141	Q96DX5
RVHCRAARTIANQAV	ANKRD11	2536	Q6UB99
GGSVQEVQRLTRACH	ABO	271	P16442
RFCNTVHDIVNRGGR	CPSF3	221	Q9UKF6
AGQRCTTARRLFIHE	ALDH7A1	326	P49419
CESSNRALSLQHAGR	ALS2	916	Q96Q42
RLRATHGCRNPTLVQ	ACRBP	61	Q8NEB7
ISLFGRDCSVQRRHQ	ACACA	371	Q13085
RRNARCLVNGLSLDH	APBB1	506	O00213
NSGSIRHELQCDLRR	AMBRA1	491	Q9C0C7
GNHRCSLSGEDLNRQ	AGBL1	851	Q96MI9
ASERRFGILSNCNHT	MKRN2	251	Q9H000
ACSRSGQRVLHIDSR	CHML	26	P26374
LRCREATQAGQRLLH	RANBP17	956	Q9H2T7
RRQTSLNHLCQASRT	RFX4	321	Q33E94
NSEVRGHLGRACQER	RIMBP3B	636	A6NNM3
NSEVRGHLGRACQER	RIMBP3C	636	A6NJZ7
RRNLAHLCRATTTIQ	IQCN	966	Q9H0B3
QDGRARTVSDHRCFQ	IQCN	1021	Q9H0B3
SVGANHQRDARRACA	HCFC1	1126	P51610
QVSSRDHGQRVTCRA	NPHS1	611	O60500
RRHDNGLNRVCAEGN	FBXW9	426	Q5XUX1
CHNRTAQRQRSGSRE	JMY	46	Q8N9B5
HRVIQVACGSRDAQT	HERC2	3151	O95714
QAAVASGCLTRHAAR	KMT5B	501	Q4FZB7
NASQARVDAHRCIVR	EIF3M	196	Q7L2H7
GFQSRRVECVHARTN	ADAMTSL1	1686	Q8N6G6
QCIAAISRQAGHRIG	CAND1	236	Q86VP6
EVSHRLNCSREARGS	MPPE1	216	Q53F39
SNCNHRLATDTRVRQ	KIAA1586	756	Q9HCI6
RAQGSGCQRHVTRAK	PRF1	96	P14222
RSNVAALARQQCLGA	PDE4C	166	Q08493
FSDCHSRVLEQLRGN	EEF2KMT	186	Q96G04
ASACRNILERNQTHA	GP2	281	P55259
NHRVLSCGDNSRGQL	HERC6	41	Q8IVU3
ESSSQEVARLRRGQC	MYOC	171	Q99972
TDNHDRSQGLRIFCN	KCTD4	146	Q8WVF5
CLNSQPHARGSSRAI	LILRB2	166	Q8N423
GVTSQERHCLQQRRK	ADAMTSL2	66	Q86TH1
VTRSAQAARQVHLCR	PKLR	496	P30613
VICHRGFNSRSNLRS	PRDM12	246	Q9H4Q4
GHLVSRRAACTIQTA	IQSEC3	311	Q9UPP2
REGRDASCSLNQHLQ	NBPF1	656	Q3BBV0
TRHAVKIQASCRARG	MOCS1	571	Q9NZB8
ERCSGLHVNSARRLE	SBF1	551	O95248
DRHSLRQDGSRCELQ	OBSCN	3756	Q5VST9
NSILVCAEEQGHRAR	GASK1A	86	Q9UFP1
ESAVHRGRQVSSECQ	GLG1	406	Q92896
IRRTAAGSAVSICQH	HTT	266	P42858
LERERAALCARQSGH	DOCK8-AS1	126	Q5T8R8
TCRVDHRGLTFQQNA	IGHM	196	P01871
GNCSRISRGLHFITR	GCNT7	86	Q6ZNI0
QADTARTARRLHTAC	CROCC2	256	H7BZ55
QTAARELGRHGIRCN	HSD17B8	181	Q92506
RAAEVCSLHLCRNNG	HYAL4	371	Q2M3T9
LSHLQRSGERDCQEF	CARD19	66	Q96LW7
CARLRHVARGIADAQ	IFNL4	76	K9M1U5
SQLQACREASQHRAL	MCF2L	946	O15068
VHQDDCAIGRSRRVQ	LYPD5	141	Q6UWN5
CAIGRSRRVQCHQDQ	LYPD5	146	Q6UWN5
SCHRAAQSRGASLLQ	KHNYN	331	O15037
AQNVHNDRGKAVRCR	KATNA1	141	O75449
RELHRQTGNGFRCLN	LAMC2	41	Q13753
CEEGQAASRRLHQSL	EMILIN3	341	Q9NT22
RQCGSQASVKRLRAH	COG2	356	Q14746
AQEAALVARGCTHIR	GRIK4	906	Q16099
SRQRSGDNLVCHARD	CRLF1	106	O75462
LVSLSACGRTARRQQ	NEURL4	51	Q96JN8
HQITNERGESSCDRL	MIA2	1176	Q96PC5
THNCRADQVCINLRG	EFEMP1	181	Q12805
HQCISRRAENARSAS	GAB2	196	Q9UQC2
GRDGIVATRLCTHQD	PIF1	416	Q9H611
NSEVRGHLGRACQER	RIMBP3	636	Q9UFD9
RRQLASRGSSVCHVD	NAV2	851	Q8IVL1
VRTLRHCRTNQFGDL	RAPGEF5	531	Q92565
RDCQIAHGAAQFLRE	POLR2B	1091	P30876
QVAAQLLERRRGSHC	SMIM23	16	A6NLE4
IFNRDGCSVLQRHSR	SHLD1	151	Q8IYI0
CRAQERAGHGQLAQL	SHISA9	21	B4DS77
AQAQDRCHRIGQTRD	SRCAP	2146	Q6ZRS2
GALHTQIGARQDRSC	RHPN1	221	Q8TCX5
RRNTGLSHELCRVAI	NCKIPSD	321	Q9NZQ3
CSRLHQGQTVQRRLT	SPTBN5	281	Q9NRC6
NRNTHRSLSGCPIAA	ST18	426	O60284
VFNNRGCRGEELRTH	ABHD1	156	Q96SE0
QRCELNRHTTEAAAG	PKP3	616	Q9Y446
HLNNCGEFRAVRDIS	XPR1	616	Q9UBH6
KRITRNVTCQDTRHG	TMEM199	116	Q8N511
NCNTLDRDHSLFGRV	WNT2	86	P09544
RHLRSQLGRLCESNE	ZNF77	101	Q15935
ECGRGFQRRASLVQH	ZSCAN10	381	Q96SZ4
GRNLSRNHGLERLCE	ZNF555	101	Q8NEP9
DALHANGGLCRRESQ	RGS12	921	O14924
RDGLTAVHCATRQRN	SHANK3	181	Q9BYB0
AVHCATRQRNAAALT	SHANK3	186	Q9BYB0
ENSCSHGRIQRVQRR	SPATA8	66	Q6RVD6
RSLQSVAEERAGRHC	RPL15	96	P61313
SSQNVNCRDLEGRHS	TNKS	671	O95271
NRLRIHSIRATCASG	TKTL2	21	Q9H0I9
GQRERATAILLACRH	SREBF2	1076	Q12772
CNSQLARHRRIHTGE	ZNF808	466	Q8N4W9
LHTCREGNQHAAELR	NF1	121	P21359
RNGKVQHCRIHSRQD	PLCG1	601	P19174
ALSRALVQCSSHRAR	SLC35C2	61	Q9NQQ7
EHANCLSTGLNTRRC	STAB1	2146	Q9NY15
HGRILRCQLSVANHR	SIGLEC1	211	Q9BZZ2
RCQLSVANHRAQSEI	SIGLEC1	216	Q9BZZ2
AGQQSRIHCTRLAGD	ATIC	446	P31939
SRLRESVACLDRQGH	TRIM17	216	Q9Y577
CGRIFRQNSDLVNHR	ZNF841	206	Q6ZN19
ANSHIFRRGDLRSIC	TRIM49D1	296	C9J1S8
CSRTFQGSSDLIRHQ	ZNF594	766	Q96JF6
RREKALNLHSRTGCQ	ZNF142	846	P52746
GHRLNITAENDCRRL	XPO6	536	Q96QU8
SCIHNDSFTGLRNVR	SLIT1	626	O75093
GTLTNRRCALNEERT	TET2	1256	Q6N021
RCSSQLQVHGRAHCI	ZNF433	656	Q8N7K0
ESFCGRTLRNRSIAH	ZZZ3	21	Q8IYH5
RANRAVAILCNHQRA	TOP1	621	P11387
QRGSLAVHQRSCSQR	ZNF32	256	P17041
QAEDRAHRIGQCSSV	ZRANB3	426	Q5FWF4
GLVRQCQTIHGRDRT	MOSMO	41	Q8NHV5
EDRNARLGECVNLSH	NLRP12	141	P59046
DRARCSAGAHTLLVQ	NLRP12	676	P59046
CVARNAAGHTERLVS	MXRA5	2616	Q9NR99