Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MPP3 SH2B3 RTTN PEX6 ICE1 BTAF1 LRRK1 INO80 REV3L ANKHD1 ZZEF1 GDPD5 SBF2 PKD1 OGDHL MAFF NOTCH1 RAB11FIP3	1.20e-08	1105	110	18	35748872
Pubmed	Glycogen synthase: a putative locus for diet-induced hyperglycemia.	KLK3 GYS1 KLK2	6.11e-07	6	110	3	8040269
Pubmed	NGF controls dendrite development in hippocampal neurons by binding to p75NTR and modulating the cellular targets of Notch.	KLK3 KLK2 NOTCH1	2.55e-06	9	110	3	15496460
Pubmed	Suppression of DNA Double-Strand Break Formation by DNA Polymerase β in Active DNA Demethylation Is Required for Development of Hippocampal Pyramidal Neurons.	GAD1 POLB TP53BP1	4.99e-06	11	110	3	33087478
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	POLB INO80 ANKHD1 PABPC1 USP19 NUBP2 IFNAR2 MRPL4 BRF1 PKD1 MAFF MRTFA TEDC1	7.54e-06	925	110	13	28986522
Pubmed	Genetic variation in KLK2 and KLK3 is associated with concentrations of hK2 and PSA in serum and seminal plasma in young men.	KLK3 KLK2	9.91e-06	2	110	2	24270797
Pubmed	The predictive value of prostate cancer biomarkers depends on age and time to diagnosis: towards a biologically-based screening strategy.	KLK3 KLK2	9.91e-06	2	110	2	17657743
Pubmed	Fibulin-3 promotes glioma growth and resistance through a novel paracrine regulation of Notch signaling.	EFEMP1 NOTCH1	9.91e-06	2	110	2	22665268
Pubmed	Neuronal glycogen synthesis contributes to physiological aging.	NHLRC1 GYS1	9.91e-06	2	110	2	25059425
Pubmed	Evaluation of molecular forms of prostate-specific antigen and human kallikrein 2 in predicting biochemical failure after radical prostatectomy.	KLK3 KLK2	9.91e-06	2	110	2	19003994
Pubmed	A common sex-dependent mutation in a RET enhancer underlies Hirschsprung disease risk.	RASGEF1A RET	9.91e-06	2	110	2	15829955
Pubmed	Association of established hypothyroidism-associated genetic variants with Hashimoto's thyroiditis.	SH2B3 PDE8B	9.91e-06	2	110	2	28382505
Pubmed	Proteomic analysis of patient tissue reveals PSA protein in the stroma of benign prostatic hyperplasia.	KLK3 KLK2	9.91e-06	2	110	2	24711254
Pubmed	Risk assessment for biochemical recurrence prior to radical prostatectomy: significant enhancement contributed by human glandular kallikrein 2 (hK2) and free prostate specific antigen (PSA) in men with moderate PSA-elevation in serum.	KLK3 KLK2	9.91e-06	2	110	2	16152616
Pubmed	Ethnic variation in kallikrein expression in nipple aspirate fluid.	KLK3 KLK2	9.91e-06	2	110	2	12209605
Pubmed	Unusual alternative splicing within the human kallikrein genes KLK2 and KLK3 gives rise to novel prostate-specific proteins.	KLK3 KLK2	9.91e-06	2	110	2	11834722
Pubmed	Neurodegeneration and functional impairments associated with glycogen synthase accumulation in a mouse model of Lafora disease.	NHLRC1 GYS1	9.91e-06	2	110	2	21882344
Pubmed	Detection of prostate specific transcripts in the peripheral blood during brachytherapy predicts postoperative PSA kinetics.	KLK3 KLK2	9.91e-06	2	110	2	19434652
Pubmed	Interaction between RGS7 and polycystin.	RGS7 PKD1	9.91e-06	2	110	2	10339594
Pubmed	ZFP804A mutant mice display sex-dependent schizophrenia-like behaviors.	GAD1 ZNF804A	9.91e-06	2	110	2	33303946
Pubmed	Early prediction of prostate cancer biochemical recurrence and identification of disease persistence using PSA isoforms and human kallikrein-2.	KLK3 KLK2	9.91e-06	2	110	2	34486998
Pubmed	Tagging SNPs in the kallikrein genes 3 and 2 on 19q13 and their associations with prostate cancer in men of European origin.	KLK3 KLK2	9.91e-06	2	110	2	17593395
Pubmed	Identifying candidate Hirschsprung disease-associated RET variants.	RASGEF1A RET	9.91e-06	2	110	2	15759212
Pubmed	Interleukin-11 promotes the progress of gastric carcinoma via abnormally expressed versican.	IL11 VCAN	9.91e-06	2	110	2	22393310
Pubmed	Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling.	IL11 SH2B3	9.91e-06	2	110	2	24297922
Pubmed	Notch1 signaling pathway promotes growth and metastasis of gastric cancer via modulating CDH5.	CDH5 NOTCH1	9.91e-06	2	110	2	39172098
Pubmed	Predictive value of four kallikrein markers for pathologically insignificant compared with aggressive prostate cancer in radical prostatectomy specimens: results from the European Randomized Study of Screening for Prostate Cancer section Rotterdam.	KLK3 KLK2	9.91e-06	2	110	2	23683475
Pubmed	Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo.	EMILIN1 JUP PKD1	1.09e-05	14	110	3	31475747
Pubmed	Abnormal Mammary Development in 129:STAT1-Null Mice is Stroma-Dependent.	KLK3 F5 VCAN KLK2	1.17e-05	44	110	4	26075897
Pubmed	Critical role of tissue kallikrein in vessel formation and maturation: implications for therapeutic revascularization.	KLK3 KLK2	2.97e-05	3	110	2	19164804
Pubmed	Regional and global protective effects of tissue kallikrein gene delivery to the peri-infarct myocardium.	KLK3 KLK2	2.97e-05	3	110	2	17465807
Pubmed	Slc35c2 promotes Notch1 fucosylation and is required for optimal Notch signaling in mammalian cells.	SLC35C1 NOTCH1	2.97e-05	3	110	2	20837470
Pubmed	Mouse kallikrein arginyl-esteropeptidase genes: analysis of cloned cDNAs suggests rapid functional divergence from a common ancestral sequence.	KLK3 KLK2	2.97e-05	3	110	2	6926406
Pubmed	7S Nerve growth factor alpha and gamma subunits are closely related proteins.	KLK3 KLK2	2.97e-05	3	110	2	6712944
Pubmed	VE-cadherin and desmoplakin are assembled into dermal microvascular endothelial intercellular junctions: a pivotal role for plakoglobin in the recruitment of desmoplakin to intercellular junctions.	JUP CDH5	2.97e-05	3	110	2	9739078
Pubmed	Astrocytes and neurons produce distinct types of polyglucosan bodies in Lafora disease.	NHLRC1 GYS1	2.97e-05	3	110	2	30152044
Pubmed	Tissue kallikrein is essential for invasive capacity of circulating proangiogenic cells.	KLK3 KLK2	2.97e-05	3	110	2	21164105
Pubmed	Tissue kallikrein stimulates Ca(2+) reabsorption via PKC-dependent plasma membrane accumulation of TRPV5.	KLK3 KLK2	2.97e-05	3	110	2	17006539
Pubmed	Characterization of mouse glandular kallikrein 24 expressed in testicular Leydig cells.	KLK3 KLK2	2.97e-05	3	110	2	15985384
Pubmed	Characterization of androgen receptor and nuclear receptor co-regulator expression in human breast cancer cell lines exhibiting differential regulation of kallikreins 2 and 3.	KLK3 KLK2	2.97e-05	3	110	2	12124798
Pubmed	Porcine kallikrein gene family: genomic structure, mapping, and differential expression analysis.	KLK3 KLK2	2.97e-05	3	110	2	17210241
Pubmed	Detection of a kallikrein in the mouse lactating mammary gland: a possible processing enzyme for the epidermal growth factor precursor.	KLK3 KLK2	2.97e-05	3	110	2	7525260
Pubmed	Identification of mK1, a true tissue (glandular) kallikrein of mouse submandibular gland: tissue distribution and a comparison of kinin-releasing activity with other submandibular kallikreins.	KLK3 KLK2	2.97e-05	3	110	2	8188620
Pubmed	VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF.	JUP CDH5	2.97e-05	3	110	2	19015309
Pubmed	Mouse testicular Leydig cells express Klk21, a tissue kallikrein that cleaves fibronectin and IGF-binding protein-3.	KLK3 KLK2	2.97e-05	3	110	2	11606460
Pubmed	The amino acid sequence of the gamma-subunit of mouse submaxillary gland 7 S nerve growth factor.	KLK3 KLK2	2.97e-05	3	110	2	7263706
Pubmed	Histone acetyltransferase p300 promotes MRTF-A-mediates transactivation of VE-cadherin gene in human umbilical vein endothelial cells.	CDH5 MRTFA	2.97e-05	3	110	2	25746323
Pubmed	A cytocidal tissue kallikrein isolated from mouse submandibular glands.	KLK3 KLK2	2.97e-05	3	110	2	2583286
Pubmed	Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors.	GAD1 NPAS1	2.97e-05	3	110	2	15347806
Pubmed	Inducible expression of kallikrein in renal tubular cells protects mice against spontaneous lupus nephritis.	KLK3 KLK2	2.97e-05	3	110	2	23280471
Pubmed	Mouse glandular kallikrein genes. Nucleotide sequence of cloned cDNA coding for a member of the kallikrein arginyl esteropeptidase group of serine proteases.	KLK3 KLK2	2.97e-05	3	110	2	6174512
Pubmed	Low-density lipoprotein receptor-related protein 1 polymorphism 663 C > T affects clotting factor VIII activity and increases the risk of venous thromboembolism.	F5 LRP1	2.97e-05	3	110	2	17155964
Pubmed	Protease-activated receptor dependent and independent signaling by kallikreins 1 and 6 in CNS neuron and astroglial cell lines.	KLK3 KLK2	2.97e-05	3	110	2	18778305
Pubmed	miR-206 Inhibits Stemness and Metastasis of Breast Cancer by Targeting MKL1/IL11 Pathway.	IL11 MRTFA	2.97e-05	3	110	2	27435395
Pubmed	Single-chain tissue-type plasminogen activator is a substrate of mouse glandular kallikrein 24.	KLK3 KLK2	2.97e-05	3	110	2	16286722
Pubmed	mGK-6-derived true tissue kallikrein is synthesized, processed, and targeted through a regulated secretory pathway in mouse pituitary AtT-20 cells.	KLK3 KLK2	2.97e-05	3	110	2	1639762
Pubmed	Serendipitous Discovery of T Cell-Produced KLK1b22 as a Regulator of Systemic Metabolism.	KLK3 KLK2	2.97e-05	3	110	2	37358498
Pubmed	Deletion of kallikrein 1b5 (Klk1b5) has no impact on fertility in mice.	KLK3 KLK2	2.97e-05	3	110	2	30957940
Pubmed	Blocking of plasma kallikrein ameliorates stroke by reducing thromboinflammation.	KLK3 KLK2	2.97e-05	3	110	2	25628066
Pubmed	Notch1 activation in embryonic VE-cadherin populations selectively blocks hematopoietic stem cell generation and fetal liver hematopoiesis.	CDH5 NOTCH1	2.97e-05	3	110	2	22851140
Pubmed	Targeting kallikrein 6 proteolysis attenuates CNS inflammatory disease.	KLK3 KLK2	2.97e-05	3	110	2	15033932
Pubmed	Cellular basis for the differential response of mouse kallikrein genes to hormonal induction.	KLK3 KLK2	2.97e-05	3	110	2	3649290
Pubmed	Laforin is required for the functional activation of malin in endoplasmic reticulum stress resistance in neuronal cells.	NHLRC1 GYS1	2.97e-05	3	110	2	22578008
Pubmed	Kallikrein-related peptidases.	KLK3 KLK2	2.97e-05	3	110	2	18344018
Pubmed	Positive selection shaped the convergent evolution of independently expanded kallikrein subfamilies expressed in mouse and rat saliva proteomes.	KLK3 KLK2	2.97e-05	3	110	2	21695125
Pubmed	Uterine artery structural and functional changes during pregnancy in tissue kallikrein-deficient mice.	KLK3 KLK2	2.97e-05	3	110	2	12933530
Pubmed	The lupus-susceptibility gene kallikrein downmodulates antibody-mediated glomerulonephritis.	KLK3 KLK2	2.97e-05	3	110	2	19262577
Pubmed	Renin and kallikrein in connecting tubule of mouse.	KLK3 KLK2	2.97e-05	3	110	2	14633138
Pubmed	Sequence of mGK-11, a mouse glandular kallikrein gene.	KLK3 KLK2	2.97e-05	3	110	2	3205728
Pubmed	Structure of mouse kallikrein gene family suggests a role in specific processing of biologically active peptides.	KLK3 KLK2	2.97e-05	3	110	2	6602295
Pubmed	A complete cDNA sequence for the major epidermal growth factor binding protein in the male mouse submandibular gland.	KLK3 KLK2	2.97e-05	3	110	2	3322386
Pubmed	beta-NGF-endopeptidase: structure and activity of a kallikrein encoded by the gene mGK-22.	KLK3 KLK2	2.97e-05	3	110	2	2012805
Pubmed	Kallikrein protects against microalbuminuria in experimental type I diabetes.	KLK3 KLK2	2.97e-05	3	110	2	19516248
Pubmed	Autoimmunity against a tissue kallikrein in IQI/Jic Mice: a model for Sjogren's syndrome.	KLK3 KLK2	2.97e-05	3	110	2	15545270
Pubmed	Sequence and expression of mouse gamma-renin.	KLK3 KLK2	2.97e-05	3	110	2	3288617
Pubmed	Plakoglobin maintains the integrity of vascular endothelial cell junctions and regulates VEGF-induced phosphorylation of VE-cadherin.	JUP CDH5	2.97e-05	3	110	2	28158602
Pubmed	Sequence of an epidermal growth factor-binding protein.	KLK3 KLK2	2.97e-05	3	110	2	6330081
Pubmed	Cloning and characterization of mouse klk27, a novel tissue kallikrein expressed in testicular Leydig cells and exhibiting chymotrypsin-like specificity.	KLK3 KLK2	2.97e-05	3	110	2	11082197
Pubmed	Mouse glandular kallikrein genes. Identification, structure, and expression of the renal kallikrein gene.	KLK3 KLK2	2.97e-05	3	110	2	3007510
Pubmed	Role of tissue kallikrein in response to flow in mouse resistance arteries.	KLK3 KLK2	2.97e-05	3	110	2	15126916
Pubmed	The molecular biology of the kallikrein-kinin system: I. General description, nomenclature and the mouse gene family.	KLK3 KLK2	2.97e-05	3	110	2	8228186
Pubmed	The sequence of a cDNA clone coding for a novel kallikrein from mouse submaxillary gland.	KLK3 KLK2	2.97e-05	3	110	2	3636812
Pubmed	Reduction in nerve growth factor availability leads to a conditioning lesion-like effect in sympathetic neurons.	KLK3 KLK2	2.97e-05	3	110	2	16967509
Pubmed	Growth factor-binding proteases in the murine submaxillary gland: isolation of a cDNA clone.	KLK3 KLK2	2.97e-05	3	110	2	11892812
Pubmed	Cardiovascular abnormalities with normal blood pressure in tissue kallikrein-deficient mice.	KLK3 KLK2	2.97e-05	3	110	2	11226291
Pubmed	Sequence of the mouse glandular kallikrein gene, mGK-5.	KLK3 KLK2	2.97e-05	3	110	2	3502721
Pubmed	Kallikrein 6 regulates early CNS demyelination in a viral model of multiple sclerosis.	KLK3 KLK2	2.97e-05	3	110	2	22335454
Pubmed	Isolation of a cDNA clone coding for the gamma-subunit of mouse nerve growth factor using a high-stringency selection procedure.	KLK3 KLK2	2.97e-05	3	110	2	6548955
Pubmed	Interference of kallikrein 1b26 (klk1b26) translation by microRNA specifically expressed in female mouse submandibular glands: an additional mechanism for sexual dimorphism of klk1b26 protein in the glands.	KLK3 KLK2	2.97e-05	3	110	2	22085651
Pubmed	Sites of glandular kallikrein gene expression in fetal mice.	KLK3 KLK2	2.97e-05	3	110	2	1334010
Pubmed	Glycogen accumulation underlies neurodegeneration and autophagy impairment in Lafora disease.	NHLRC1 GYS1	2.97e-05	3	110	2	24452334
Pubmed	Tissue kallikrein deficiency and renovascular hypertension in the mouse.	KLK3 KLK2	2.97e-05	3	110	2	19244588
Pubmed	Differences in substrate and inhibitor sequence specificity of human, mouse and rat tissue kallikreins.	KLK3 KLK2	2.97e-05	3	110	2	15040788
Pubmed	Genetic deficiency in tissue kallikrein activity in mouse and man: effect on arteries, heart and kidney.	KLK3 KLK2	2.97e-05	3	110	2	18627303
Pubmed	Tissue kallikrein is required for the cardioprotective effect of cyclosporin A in myocardial ischemia in the mouse.	KLK3 KLK2	2.97e-05	3	110	2	25623731
Pubmed	Estrogen-dependent expression of the tissue kallikrein gene (Klk1) in the mouse uterus and its implications for endometrial tissue growth.	KLK3 KLK2	2.97e-05	3	110	2	17219431
Pubmed	Analysis of androgen and anti-androgen regulation of KLK-related peptidase 2, 3, and 4 alternative transcripts in prostate cancer.	KLK3 KLK2	2.97e-05	3	110	2	25153393
Pubmed	Mechanisms Regulating Acquisition of Platelet-Derived Factor V/Va by Megakaryocytes.	F5 LRP1	2.97e-05	3	110	2	25800007
Pubmed	A comprehensive resequence analysis of the KLK15-KLK3-KLK2 locus on chromosome 19q13.33.	KLK3 KLK2	2.97e-05	3	110	2	19823874
Pubmed	Antihypertensive role of tissue kallikrein in hyperaldosteronism in the mouse.	KLK3 KLK2	2.97e-05	3	110	2	22669897
Coexpression	KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP	SECISBP2L ERICH1 WDR4 SH2B3 NOC3L SPG11 RET USP19 IKZF5 TXNIP STK4 TRAFD1 TSR1 PKD1 MAFF	9.39e-06	942	110	15	M8144
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	SECISBP2L ZHX3 SPG11 BTAF1 REV3L ZZEF1 ZNF804A RGS7 GCC2 NMT2 SEC24B TP53BP1 MRTFA SAMD4A	1.42e-05	856	110	14	M4500
Coexpression	KAECH_DAY8_EFF_VS_MEMORY_CD8_TCELL_DN	IFNAR2 TSR1 SBF2 PKD1 RERE NOTCH1 TP53BP1	2.15e-05	199	110	7	M3028
ToppCell	normal_Lymph_Node-Myeloid_cells-pDCs\|normal_Lymph_Node / Location, Cell class and cell subclass	SH2B3 POLB CASP10 ANKHD1 RGS7 CASD1 BRF1	2.82e-07	176	110	7	476794ef75ce5ab732d78cfeb4944e2f841e3e92
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 ATP10A EMILIN1 PDE8B VCAN LRP1 KCNQ3	5.83e-07	196	110	7	ba869f7a86f37fd6d84d6ad69baca0e0faaf5887
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 ATP10A EMILIN1 PDE8B VCAN LRP1 KCNQ3	5.83e-07	196	110	7	30ad56d49000e4ddce73b4443b3994564bd1e2d6
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	SECISBP2L GAD1 CASP10 TXNIP FGD3 MX2 NPAS1	6.67e-07	200	110	7	e16bde12326f0cfc4d03f9307cba0e21ea2389cb
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW19-Neuronal-GABAergic_neurons\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	GAD1 EFEMP1 TMTC4 FGD3 NPAS1	2.66e-06	88	110	5	5582fd7bac60c690ecd1f2aff1d446ccb69f79b9
ToppCell	normal_Lymph_Node-Myeloid_cells-pDCs\|Myeloid_cells / Location, Cell class and cell subclass	POLB CASP10 ANKHD1 RGS7 CASD1 BRF1	4.71e-06	174	110	6	2274648b80dd74f3c948a779bba3391095964c34
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 DCDC1 PTPRD VCAN KCNQ3 RAB11FIP3	7.57e-06	189	110	6	28b502611829e4a24caff2562545c7db97686099
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	REV3L EMILIN1 PTPRD VCAN LRP1 SAMD4A	7.80e-06	190	110	6	45df8fee00f8949937863159d7aa042e72748d9b
ToppCell	Control-Endothelial-Endothelial-Gen_Cap\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CASP10 IFNAR2 STK4 PTPRD SBF2 CDH5	8.53e-06	193	110	6	e1d546165dcc2392f540162206852c4717d7306f
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)\|390C / Donor, Lineage, Cell class and subclass (all cells)	SPG11 ATP10A SMPD2 TP53BP1 SAMD4A RAB11FIP3	8.78e-06	194	110	6	88db9f9e80c20ff3474f1f6459dcbdc25aec0b6d
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	SPG11 ATP10A SMPD2 TP53BP1 SAMD4A RAB11FIP3	8.78e-06	194	110	6	a71728202493d4858342ea2756ea281cd0d99a3a
ToppCell	B_cells-ISG-high_B_cells\|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis	SECISBP2L ATP10A JUP TRAFD1 MX2 SAMD4A	9.04e-06	195	110	6	b64d9e1a8834401b4dc501566546647754ae21fc
ToppCell	severe-CD163+_Monocytes_(Sample_ID1_d7)\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	F5 JUP VCAN LRP1 MX2 SAMD4A	1.04e-05	200	110	6	4943fe826d5fcc3dfeb8b99a7415848f3fecc994
ToppCell	Cerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	GAD1 RET ZNF804A GDPD5 CA7	5.93e-05	167	110	5	9efb9511a211d0824bb97f82c1a5860c43d2138f
ToppCell	Cerebellum-Neuronal-Inhibitory\|Cerebellum / BrainAtlas - Mouse McCarroll V32	GAD1 RET ZNF804A GDPD5 CA7	5.93e-05	167	110	5	904c613aac3f9919a432b110bb1dcc832b5aec0a
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	SPG11 ATP10A TP53BP1 SAMD4A RAB11FIP3	6.27e-05	169	110	5	665b958f4a720ca369a8a0abc7fbe8b6e13c8ce5
ToppCell	390C-Epithelial_cells-Epithelial-I_(AT1)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	SPG11 ATP10A TP53BP1 SAMD4A RAB11FIP3	6.27e-05	169	110	5	6614c9851537e4c21b1e45ff0cc3bad07ef9d034
ToppCell	droplet-Skin-nan-18m-Epithelial-keratinocyte_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 RET F5 PTPRD VCAN	6.45e-05	170	110	5	10e0912dd0beab5d0bbe2bd49e477b5962687925
ToppCell	NS-critical-d_0-4-Epithelial-FOXN4+\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ZHX3 RTTN ZNF804A SMN1 NPAS1	6.82e-05	172	110	5	a00bb44d33658cb3a98accd6b60f3ce964c425b4
ToppCell	COVID-19_Mild-PLT_2\|COVID-19_Mild / Disease Group and Platelet Clusters	AMPD3 F5 ATP10A ULK3 TMTC4	7.01e-05	173	110	5	d11705e56b6b21eec963ea224717f27680c781ed
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_D\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	RASGEF1A CFAP65 JUP CDH5 NOTCH1	7.20e-05	174	110	5	b4f3f5334803e5903bc496decf923f2e44f7fa3c
ToppCell	facs-Lung-Endomucin-24m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAH2 RASGEF1A JUP CDH5 NOTCH1	7.20e-05	174	110	5	ea27868d0373843a5137569ac3f9e3f8c92c7dcc
ToppCell	facs-Lung-Endomucin-24m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAH2 RASGEF1A JUP CDH5 NOTCH1	7.20e-05	174	110	5	60a426bfe5625999f031776ab34f7bc0d2b331be
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GAD1 GDPD5 TMTC4 CDH5 NOTCH1	7.40e-05	175	110	5	43be63976da5ad0764d24d90919a77ce46068f52
ToppCell	facs-Lung-Endomucin-24m-Endothelial-endothelial_cell_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAH2 RASGEF1A JUP CDH5 NOTCH1	7.40e-05	175	110	5	eedb33e3e350169d1d37f2ac9939dcf704e7b696
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DNAH2 RASGEF1A JUP CDH5 NOTCH1	7.40e-05	175	110	5	1c7725f917f3d6b9e0a31ede9524690f408a5ea1
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-4\|TCGA-Lung / Sample_Type by Project: Shred V9	ITGA11 IFNAR2 VCAN KCNQ3 SAMD4A	7.60e-05	176	110	5	0923b01137d6f9956ca815b41102c81e82624065
ToppCell	P15-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	RASGEF1A STK4 JUP GCC2 CDH5	8.45e-05	180	110	5	410ea13a9c00cf54b4d47c72404dfe893c086d87
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_D_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGEF1A F5 RGS7 VCAN CACNA1G	8.45e-05	180	110	5	8bf6e8b6b45ce42f8c5f23e7cd1752ec8b3fa2d2
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 EMILIN1 PDE8B VCAN LRP1	8.67e-05	181	110	5	6d1f1ad35778a2a227f966f11f6edd8e89452576
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l44-58\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	IL11 ITGA11 PP2D1 ZMYM6 MX2	9.13e-05	183	110	5	dc9602bed3136db91faeffef177006246dc92743
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 ZHX3 RTTN TMEM132E RAB11FIP3	9.86e-05	186	110	5	5784d255e9ca449d375d81938d0fbbd8a7eb44f6
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 PTPRD KCNQ3 SAMD4A RAB11FIP3	1.01e-04	187	110	5	9d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-7\|TCGA-Colorectal / Sample_Type by Project: Shred V9	ITGA11 STK4 GDPD5 TMTC4 VCAN	1.04e-04	188	110	5	14bc73cf79c79c9f208369fd8d498e5b26e0114d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 DCDC1 PTPRD KCNQ3 SAMD4A	1.06e-04	189	110	5	3b48b0d220cc24d5170713d61fa91f5bb6c21841
ToppCell	COVID-19-kidney-PCT-S2\|kidney / Disease (COVID-19 only), tissue and cell type	PRUNE2 PTPRD KCNQ3 SAMD4A RAB11FIP3	1.06e-04	189	110	5	0be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCell	droplet-Mammary_Gland-nan-3m-Mesenchymal\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMILIN1 EFEMP1 VCAN LRP1 SAMD4A	1.09e-04	190	110	5	bd0d68dc1b6f388190a6ba8a83b011619abe2bdd
ToppCell	droplet-Mammary_Gland-nan-3m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMILIN1 EFEMP1 VCAN LRP1 SAMD4A	1.09e-04	190	110	5	e275de94468872e70cf305b3b450823d4c9c5e3f
ToppCell	droplet-Mammary_Gland-nan-3m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EMILIN1 EFEMP1 VCAN LRP1 SAMD4A	1.09e-04	190	110	5	ee2f4a55d2fd18b83e55399b5b5697a15a2d2e70
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 PTPRD KCNQ3 SAMD4A RAB11FIP3	1.09e-04	190	110	5	989d4eefd22d66ecb857836f8fdbcf41e3047f84
ToppCell	5'-Adult-LymphNode-Epithelial-goblet-BEST2+_Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NUBP2 CUTC CASD1 TP53BP1 FGD3	1.12e-04	191	110	5	e5c41c3054ead03597c136eaccaf9822e6bb9d1a
ToppCell	5'-Adult-LymphNode-Epithelial-goblet\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NUBP2 CUTC CASD1 TP53BP1 FGD3	1.12e-04	191	110	5	7e24175c7fabe5ea0b22b73173da4c3a666e5eb8
ToppCell	facs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA11 RET EMILIN1 VCAN LRP1	1.14e-04	192	110	5	671d4e1eee5aba03c43dbc98f4b51ce42b3df5d5
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	REV3L EMILIN1 PTPRD LRP1 SAMD4A	1.14e-04	192	110	5	df1545670370fb1010c567cd059c2783eab315f7
ToppCell	facs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITGA11 RET EMILIN1 VCAN LRP1	1.14e-04	192	110	5	840a34c1b82d218be999ab5e1bcafd6370d7a4b1
ToppCell	PND10-Endothelial-Endothelial_blood-vessel\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RASGEF1A JUP GCC2 CDH5 NOTCH1	1.17e-04	193	110	5	1d8acf81dcbfe81c7a73ce50c9f38fe0cbc74486
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Microvascular_EC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RASGEF1A JUP GCC2 CDH5 NOTCH1	1.17e-04	193	110	5	097a244cf37ce6c1ace9bae56beb7de59442cd6b
ToppCell	PND10-Endothelial\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RASGEF1A JUP GCC2 CDH5 NOTCH1	1.17e-04	193	110	5	f3c743b340fc588bc8effd375b12e2c7cbfa49d2
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	EMILIN1 PTPRD VCAN SBF2 RERE	1.20e-04	194	110	5	b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 ATP10A EMILIN1 VCAN LRP1	1.20e-04	194	110	5	240d122dcb9dd1ab2867503ad85869853adcacae
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 ATP10A EMILIN1 VCAN LRP1	1.20e-04	194	110	5	ae7df037592f1c20c9d32be15fe6fc3c562ebeb1
ToppCell	tumor_Lung-Myeloid_cells-Activated_DCs\|tumor_Lung / Location, Cell class and cell subclass	ERICH1 LRRK1 STK4 TRAFD1 MAFF	1.20e-04	194	110	5	a85d958aff84f2296c330a7dcd442bd2344738df
ToppCell	critical-Myeloid-Monocyte-derived_Macrophage\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ATP10A VCAN CDH5 MX2 SAMD4A	1.20e-04	194	110	5	e36d1fd141bdcbd9ed66a33de6cdfde77189a0c1
ToppCell	COVID-19_Severe-Classical_Monocyte-cMono_4\|Classical_Monocyte / Disease condition and Cell class	GDPD5 JUP MAFF MX2 SAMD4A	1.23e-04	195	110	5	1992a1673b7213e25f3c76ac77da35c57daceddd
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 ATP10A EMILIN1 VCAN LRP1	1.23e-04	195	110	5	d8ebb94f30d4a655d6b29dd6a3076be2403d2356
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 GAD1 RET EMILIN1 OGDHL	1.23e-04	195	110	5	bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	EMILIN1 PTPRD VCAN SBF2 RERE	1.23e-04	195	110	5	0e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCell	facs-Aorta-Heart-3m-Endothelial\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TXNIP JUP CDH5 NOTCH1 CA7	1.23e-04	195	110	5	8493f2f60fc356af28b9c0e287d4cd8c8899c081
ToppCell	COVID-19_Severe-Classical_Monocyte-cMono_4\|COVID-19_Severe / Disease condition and Cell class	GDPD5 JUP MAFF MX2 SAMD4A	1.23e-04	195	110	5	787ea9f38ad8e2a836222ca97f4d927f7e79517d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA11 ATP10A EMILIN1 VCAN LRP1	1.23e-04	195	110	5	44d7bef5f59c2c2bad1392ee6aabdaa5d7f531d9
ToppCell	facs-Aorta-Heart-3m-Endothelial-aortic_endothelial_cell\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TXNIP JUP CDH5 NOTCH1 CA7	1.23e-04	195	110	5	5e5ca7bd94c9e924ed76f7ccac199be745d4c4eb
ToppCell	Fibroblasts-DKK3+_Fibroblasts\|Fibroblasts / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	PRUNE2 ITGA11 F5 ATP10A PTPRD	1.26e-04	196	110	5	24d64b67aa9b0e8215ad06f9101c1314b3483620
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	EMILIN1 PTPRD VCAN SBF2 LRP1	1.26e-04	196	110	5	1450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCell	Tracheal-10x3prime_v2-Stromal-Fibroblastic-Fibro_immune_recruiting\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	MPP3 ZHX3 BRF1 TMTC4 MX2	1.29e-04	197	110	5	4edf043e8f586fd375f56485841fe992a18bf853
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	EMILIN1 PTPRD VCAN SBF2 LRP1	1.29e-04	197	110	5	31a1852911bda38543916585fda34255fd62a134
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	JUP VCAN LRP1 MX2 SAMD4A	1.29e-04	197	110	5	383d598ce3f8f5fc98bef3300e4cf7b6992aec9c
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	JUP VCAN LRP1 MX2 SAMD4A	1.29e-04	197	110	5	3cc4e56a77f96a43f9b5a24cf1b9524c927ef795
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	BRSK2 RET F5 RGS7 OGDHL	1.32e-04	198	110	5	8f25e8dff42bad8e779ca618bdb1cb1610667962
ToppCell	Control_saline-Epithelial_alveolar-AT_1-Differentiating_AT1\|Control_saline / Treatment groups by lineage, cell group, cell type	MPP3 EFEMP1 OGDHL FGD3 MX2	1.32e-04	198	110	5	85f424cd9bb3117c9e322031024aabb87696ce47
ToppCell	COVID-19-kidney-Fibroblast-2\|kidney / Disease (COVID-19 only), tissue and cell type	ITGA11 LRRK1 EMILIN1 VCAN LRP1	1.32e-04	198	110	5	ca26ca460856b1faaa3e83766da6abdf63af2b51
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	BRSK2 RET F5 RGS7 OGDHL	1.32e-04	198	110	5	e3e0aa3ef20b2370f5b133048510677aaa562dfa
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EMILIN1 TXNIP EFEMP1 VCAN LRP1	1.35e-04	199	110	5	84545ced0c792bc77980a50d65e484eab648d47e
ToppCell	COVID-19-COVID-19_Mild-Myeloid-immature_Neutrophil\|COVID-19_Mild / Disease, condition lineage and cell class	NHLRC1 AMPD3 ITGA11 EMILIN1 RECQL4	1.35e-04	199	110	5	e222b90caf45904d8f763574e7b6aac13333df92
ToppCell	LPS_only-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_only / Treatment groups by lineage, cell group, cell type	IL11 REV3L EMILIN1 VCAN LRP1	1.35e-04	199	110	5	fde2b65afde69f402f1b7b056eaa266e9fd5b227
ToppCell	LPS_IL1RA_TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	REV3L EMILIN1 PTPRD VCAN LRP1	1.35e-04	199	110	5	e1849505b92820a219c5a2c35492bdd55579fb48
ToppCell	5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ITGA11 EMILIN1 EFEMP1 VCAN LRP1	1.35e-04	199	110	5	e78f661b40da34768469549b6e755d330be6bbd8
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	IL11 REV3L PTPRD VCAN LRP1	1.35e-04	199	110	5	8b86c69aaf60feff53aa782559cfece7342a23de
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ITGA11 VCAN RECQL4 LRP1 SAMD4A	1.35e-04	199	110	5	abd6117f8a3d7e798d8471c16d97b34aaf50fc9c
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	REV3L EMILIN1 PTPRD VCAN LRP1	1.38e-04	200	110	5	9b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PRUNE2 ITGA11 PTPRD VCAN LRP1	1.38e-04	200	110	5	a4ec0e80f5422b91b85264a9bb74568dd577e285
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ITGA11 EMILIN1 EFEMP1 VCAN LRP1	1.38e-04	200	110	5	3a164e3971bcd62b148b813171c103adb81f972e
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ITGA11 EFEMP1 STARD9 VCAN LRP1	1.38e-04	200	110	5	0c25d56292b9e5fefa4521b72635449be1ffd6fe
ToppCell	MS-IIF-Lymphocyte-T/NK-dn_T\|IIF / Disease, condition lineage and cell class	IFNAR2 TMTC4 NMT2 BRD7 TP53BP1	1.38e-04	200	110	5	c34fff02992cba6bcc2308019cb00b94e1227300
Drug	Glipizide [29094-61-9]; Up 200; 9uM; MCF7; HT_HG-U133A	PRUNE2 IL11 GAD1 ZZEF1 ATP10A PPP4R4 BRF1 PDE8B KCNQ3 MRTFA	3.45e-08	195	109	10	4991_UP
Drug	Dinoprost trometamol [38362-01-5]; Up 200; 8.4uM; PC3; HT_HG-U133A	IL11 F5 USP19 PDE8B VCAN CACNA1G WIPI2 RAB11FIP3	4.38e-06	194	109	8	6308_UP
Drug	5666823; Down 200; 100uM; MCF7; HG-U133A	IL11 AMPD3 RET REV3L IKZF5 TRAFD1 BRF1 TP53BP1	4.55e-06	195	109	8	609_DN
Drug	estradiol, USP; Down 200; 0.1uM; HL60; HT_HG-U133A	PEX6 ZZEF1 BRF1 CACNA1G MAFF RERE MRTFA RAB11FIP3	4.91e-06	197	109	8	2668_DN
Drug	Nefopam hydrochloride [23327-57-3]; Up 200; 13.8uM; MCF7; HT_HG-U133A	MPP3 BEST1 AMPD3 ZZEF1 BRF1 VCAN MAFF MRTFA	4.91e-06	197	109	8	3627_UP
Drug	Sulfisoxazole [127-69-5]; Down 200; 15uM; PC3; HT_HG-U133A	GAD1 IFNAR2 TRAFD1 VCAN LRP1 MAFF RERE SAMD4A	5.09e-06	198	109	8	4661_DN
Drug	Nialamide [51-12-7]; Up 200; 13.4uM; PC3; HT_HG-U133A	PRUNE2 IMPG1 F5 PPP4R4 VCAN LRP1 CACNA1G MRTFA	5.09e-06	198	109	8	4525_UP
Drug	Nitrocaramiphen hydrochloride; Down 200; 10.8uM; HL60; HT_HG-U133A	IL11 BEST1 CASP10 LRRK1 PDE8B NMT2 MRTFA RAB11FIP3	5.29e-06	199	109	8	3125_DN
Drug	Fendiline hydrochloride [13636-18-5]; Up 200; 11.4uM; MCF7; HT_HG-U133A	AMPD3 WDR4 CASP10 LRP1 MAFF RERE SAMD4A	2.89e-05	183	109	7	3190_UP
Drug	Hydrocortisone base [50-23-7]; Up 200; 11uM; PC3; HT_HG-U133A	ZHX3 STK4 VCAN OGDHL SMPD2 KLK2 SAMD4A	3.92e-05	192	109	7	6684_UP
Drug	Clorgyline hydrochloride [17780-75-5]; Down 200; 13uM; PC3; HT_HG-U133A	IL11 WDR4 USP19 IKZF5 STK4 NMT2 MAFF	3.92e-05	192	109	7	6659_DN
Drug	Proadifen hydrochloride [62-68-0]; Up 200; 10.2uM; MCF7; HT_HG-U133A	MPP3 IL11 ZHX3 ZZEF1 USP19 KCNQ3 MAFF	4.05e-05	193	109	7	3446_UP
Drug	Chlorpheniramine maleate [113-92-8]; Up 200; 10.2uM; PC3; HT_HG-U133A	AMPD3 WDR4 F5 ATP10A BRF1 RERE RAB11FIP3	4.05e-05	193	109	7	2055_UP
Drug	Tiaprofenic acid [33005-95-7]; Down 200; 15.4uM; MCF7; HT_HG-U133A	SECISBP2L PRUNE2 GAD1 AMPD3 WIPI2 MX2 RAB11FIP3	4.19e-05	194	109	7	4171_DN
Drug	PHA-00745360 [351320-33-7]; Down 200; 10uM; PC3; HT_HG-U133A	MPP3 LRRK1 STK4 BRF1 RERE SAMD4A RAB11FIP3	4.19e-05	194	109	7	4559_DN
Drug	Pyrilamine maleate [59-33-6]; Up 200; 10uM; PC3; HT_HG-U133A	ZHX3 GAD1 LRRK1 RGS7 PPP4R4 VCAN SAMD4A	4.19e-05	194	109	7	5869_UP
Drug	(1-[(4-Chlorophenyl)phenyl-methyl]-4-methylpiperazine) [1620-21-9]; Down 200; 11.8uM; MCF7; HT_HG-U133A	IL11 WDR4 ZNF804A IFNAR2 BRF1 RERE MRTFA	4.33e-05	195	109	7	3893_DN
Drug	Gossypol [303-45-7]; Up 200; 7.8uM; MCF7; HT_HG-U133A	GAD1 AMPD3 CASP10 TXNIP CACNA1G MAFF NPAS1	4.33e-05	195	109	7	6058_UP
Drug	Dextromethorphan hydrobromide monohydrate [6700-34-1]; Up 200; 10.8uM; MCF7; HT_HG-U133A	IL11 ZHX3 USP19 CACNA1G RERE MRTFA MX2	4.33e-05	195	109	7	5401_UP
Drug	Galanthamine hydrobromide [1953-04-4]; Up 200; 10.8uM; MCF7; HT_HG-U133A	MPP3 IL11 CASP10 F5 VCAN KCNQ3 CACNA1G	4.47e-05	196	109	7	4772_UP
Drug	Nitrocaramiphen hydrochloride; Up 200; 10.8uM; MCF7; HT_HG-U133A	SLC35C1 CASP10 ZZEF1 GDPD5 RERE WIPI2 MRTFA	4.47e-05	196	109	7	6504_UP
Drug	Lynestrenol [52-76-6]; Up 200; 14uM; PC3; HT_HG-U133A	PRUNE2 IL11 IMPG1 F5 BRF1 VCAN KLK2	4.47e-05	196	109	7	6756_UP
Drug	Labetalol hydrochloride [32780-64-6]; Up 200; 11uM; PC3; HT_HG-U133A	ZHX3 CASP10 ZZEF1 ATP10A CACNA1G MRTFA RAB11FIP3	4.47e-05	196	109	7	4473_UP
Drug	N-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Down 200; 25.2uM; MCF7; HT_HG-U133A	IL11 ZZEF1 NMT2 SMPD2 NOTCH1 WIPI2 MRTFA	4.62e-05	197	109	7	3836_DN
Drug	Orlistat; Up 200; 10uM; MCF7; HT_HG-U133A	IL11 AMPD3 ZZEF1 F5 BRF1 RERE MX2	4.62e-05	197	109	7	6383_UP
Drug	Sulfameter [651-06-9]; Down 200; 14.2uM; HL60; HT_HG-U133A	PEX6 PPP4R4 STK4 GDPD5 VCAN RERE WIPI2	4.62e-05	197	109	7	2712_DN
Drug	Harmalol hydrochloride dihydrate [6028-07-5]; Up 200; 14.6uM; PC3; HT_HG-U133A	ZHX3 AMPD3 ZZEF1 RGS7 VCAN OGDHL CACNA1G	4.62e-05	197	109	7	5076_UP
Drug	Phenindione [83-12-5]; Up 200; 18uM; PC3; HT_HG-U133A	ZHX3 GAD1 CASP10 STK4 NMT2 LRP1 RAB11FIP3	4.62e-05	197	109	7	7289_UP
Drug	Carteolol hydrochloride [51781-21-6]; Up 200; 12.2uM; PC3; HT_HG-U133A	KLK3 ZZEF1 KCNQ3 RERE KLK2 CDH5 SAMD4A	4.77e-05	198	109	7	4096_UP
Drug	Meticrane [1084-65-7]; Up 200; 14.6uM; PC3; HT_HG-U133A	ZHX3 AMPD3 LRRK1 F5 PDE8B LRP1 NOTCH1	4.77e-05	198	109	7	7282_UP
Drug	0179445-0000 [211246-22-9]; Down 200; 1uM; PC3; HT_HG-U133A	PEX6 ATP10A BRF1 RERE MRTFA SAMD4A RAB11FIP3	4.77e-05	198	109	7	3736_DN
Drug	Tridihexethyl chloride; Up 200; 11.4uM; PC3; HT_HG-U133A	ZZEF1 F5 ATP10A PPP4R4 BRF1 LRP1 CDH5	4.77e-05	198	109	7	5067_UP
Drug	6-thioguanine; Down 200; 10uM; MCF7; HG-U133A	IL11 AMPD3 CASP10 GDPD5 BRF1 TSR1 RAB11FIP3	4.77e-05	198	109	7	642_DN
Drug	Ticlopidine hydrochloride [53885-35-1]; Down 200; 13.4uM; PC3; HT_HG-U133A	IL11 GAD1 RGS7 BRF1 NMT2 VCAN MAFF	4.77e-05	198	109	7	4074_DN
Drug	Etidronic acid, disodium salt [7414-83-7]; Up 200; 16uM; HL60; HT_HG-U133A	GAD1 BRF1 PDE8B LRP1 KCNQ3 SAMD4A NPAS1	4.92e-05	199	109	7	2985_UP
Drug	Ethosuximide [77-67-8]; Up 200; 28.4uM; PC3; HT_HG-U133A	ZHX3 GAD1 LRRK1 IFNAR2 NMT2 MRTFA NPAS1	4.92e-05	199	109	7	7308_UP
Drug	Finasteride [98319-26-7]; Down 200; 10.8uM; MCF7; HT_HG-U133A	IL11 GAD1 SH2B3 PEX6 ZZEF1 PPP4R4 WIPI2	4.92e-05	199	109	7	6062_DN
Drug	TTNPB; Down 200; 0.1uM; MCF7; HG-U133A	IL11 BEST1 CASP10 EFEMP1 SMPD2 MAFF RAB11FIP3	4.92e-05	199	109	7	223_DN
Drug	Amidopyrine [58-15-1]; Up 200; 17.2uM; PC3; HT_HG-U133A	ZHX3 ZNF671 CASP10 KLK3 F5 STK4 SMPD2	5.08e-05	200	109	7	4481_UP
Drug	Fenoprofen calcium salt dihydrate [53746-45-5]; Up 200; 7.2uM; PC3; HT_HG-U133A	IL11 LRRK1 ZZEF1 PPP4R4 LRP1 KCNQ3 WIPI2	5.08e-05	200	109	7	3714_UP
Drug	merbarone	KLK3 KLK2	1.35e-04	4	109	2	ctd:C045459
Drug	thapsigargin; Up 200; 0.1uM; PC3; HT_HG-U133A	IL11 GAD1 ZNF804A TXNIP MAFF SAMD4A	1.50e-04	166	109	6	7103_UP
Drug	thioridazine hydrochloride; Up 200; 10uM; PC3; HT_HG-U133A	ZHX3 ZNF804A IKZF5 MAFF RERE SAMD4A	2.12e-04	177	109	6	1230_UP
Drug	Digitoxigenin [143-62-4]; Up 200; 10.6uM; PC3; HT_HG-U133A	IL11 ZZEF1 TXNIP LRP1 MAFF SAMD4A	2.25e-04	179	109	6	4217_UP
Drug	0179445-0000 [211246-22-9]; Up 200; 10uM; MCF7; HT_HG-U133A	TXNIP BRF1 VCAN MAFF RERE MRTFA	2.25e-04	179	109	6	3630_UP
Drug	Puromycin dihydrochloride [58-58-2]; Up 200; 7.4uM; PC3; HT_HG-U133A	IL11 ZNF671 ZNF804A TXNIP CACNA1G MAFF	2.25e-04	179	109	6	6711_UP
Drug	STOCK1N-35215; Up 200; 10uM; PC3; HT_HG-U133A	IL11 GAD1 WDR4 IKZF5 MAFF SAMD4A	2.46e-04	182	109	6	6427_UP
Drug	Isoetharine mesylate salt [7279-75-6]; Up 200; 12uM; HL60; HT_HG-U133A	BEST1 KLK3 BRF1 VCAN ZMYM6 MX2	2.61e-04	184	109	6	2711_UP
Drug	retinoic acid; Up 200; 1uM; MCF7; HT_HG-U133A	ZHX3 SLC35C1 F5 GDPD5 BRF1 CDH5	2.69e-04	185	109	6	6971_UP
Drug	GBR 12909 dihydrochloride [67469-78-7]; Up 200; 7.6uM; MCF7; HT_HG-U133A	CASP10 VCAN MAFF WIPI2 MX2 SAMD4A	2.85e-04	187	109	6	3240_UP
Drug	Hycanthone [3105-97-3]; Down 200; 11.2uM; HL60; HG-U133A	SLC35C1 IKZF5 CSTF1 MAFF RERE WIPI2	2.85e-04	187	109	6	1614_DN
Drug	Azacytidine-5 [320-67-2]; Up 200; 16.4uM; PC3; HT_HG-U133A	IL11 PPP4R4 TXNIP KCNQ3 SMPD2 MAFF	2.93e-04	188	109	6	4010_UP
Drug	rapamycin, Streptomyces hygroscepicus; Up 200; 0.1uM; PC3; HT_HG-U133A	IL11 STK4 BRF1 VCAN KCNQ3 MRTFA	2.93e-04	188	109	6	5980_UP
Drug	Trifluridine [70-00-8]; Up 200; 13.6uM; MCF7; HT_HG-U133A	GAD1 SH2B3 F5 NMT2 CACNA1G MAFF	2.93e-04	188	109	6	3559_UP
Drug	Protoveratrine A [143-57-7]; Down 200; 5uM; MCF7; HT_HG-U133A	MPP3 SLC35C1 PLA2G15 BRF1 SMPD2 RAB11FIP3	3.01e-04	189	109	6	2800_DN
Drug	Ketanserin tartrate hydrate [83846-83-7]; Down 200; 7uM; PC3; HT_HG-U133A	SECISBP2L IL11 TXNIP STK4 EFEMP1 VCAN	3.01e-04	189	109	6	6649_DN
Drug	Clioquinol [130-26-7]; Up 200; 13uM; MCF7; HT_HG-U133A	AMPD3 ATP10A BRF1 PTPRD VCAN MAFF	3.10e-04	190	109	6	5623_UP
Drug	Colchicine [64-86-8]; Up 200; 10uM; PC3; HT_HG-U133A	MPP3 IL11 CACNA1G RERE MRTFA SAMD4A	3.19e-04	191	109	6	4614_UP
Drug	Norgestrel-(-)-D [797-63-7]; Down 200; 12.8uM; PC3; HT_HG-U133A	GAD1 IFNAR2 TXNIP STK4 EFEMP1 NMT2	3.19e-04	191	109	6	4269_DN
Drug	CP-690334-01 [459212-38-5]; Down 200; 10uM; PC3; HT_HG-U133A	IL11 LRRK1 RGS7 VCAN LRP1 MRTFA	3.19e-04	191	109	6	3823_DN
Drug	11-deoxy-16,16-dimethyl Prostaglandin E2; Up 200; 10uM; PC3; HT_HG-U133A	IL11 STK4 RERE NOTCH1 WIPI2 SAMD4A	3.19e-04	191	109	6	7538_UP
Drug	Deptropine citrate [2169-75-7]; Up 200; 7.6uM; PC3; HT_HG-U133A	AMPD3 BRSK2 STK4 LRP1 RERE SAMD4A	3.28e-04	192	109	6	5118_UP
Drug	Prochlorperazine dimaleate [84-02-6]; Down 200; 6.6uM; PC3; HT_HG-U133A	GAD1 ZNF671 WDR4 STK4 BRF1 TSR1	3.28e-04	192	109	6	6664_DN
Drug	Benzamil hydrochloride [2898-76-2]; Up 200; 11.2uM; MCF7; HT_HG-U133A	MPP3 ZZEF1 BRF1 PDE8B MAFF MRTFA	3.28e-04	192	109	6	3635_UP
Drug	Triprolidine hydrochloride [550-70-9]; Up 200; 12.8uM; PC3; HT_HG-U133A	LRRK1 IKZF5 LRP1 MRTFA MX2 SAMD4A	3.28e-04	192	109	6	7248_UP
Drug	Phenacetin [62-44-2]; Down 200; 22.4uM; HL60; HT_HG-U133A	PLA2G15 TXNIP STK4 TSR1 ZMYM6 MRTFA	3.28e-04	192	109	6	2471_DN
Drug	Orlistat; Up 200; 10uM; PC3; HT_HG-U133A	AMPD3 ZNF671 BRF1 PDE8B RERE MRTFA	3.28e-04	192	109	6	6388_UP
Drug	Salsolinol hydrobromide [38221-21-5]; Down 200; 15.4uM; MCF7; HT_HG-U133A	SECISBP2L FZD3 PLA2G15 TXNIP STK4 TSR1	3.28e-04	192	109	6	4816_DN
Drug	LY294002; Down 200; 10uM; MCF7; HT_HG-U133A	MPP3 GAD1 F5 PPP4R4 IKZF5 NOTCH1	3.37e-04	193	109	6	5965_DN
Drug	Pyrantel tartrate [33401-94-4]; Down 200; 11.2uM; PC3; HT_HG-U133A	GAD1 ZNF671 TXNIP STK4 VCAN WIPI2	3.37e-04	193	109	6	5088_DN
Drug	Progesterone [57-83-0]; Down 200; 12.8uM; PC3; HT_HG-U133A	PEX6 TRAFD1 EFEMP1 VCAN RERE RAB11FIP3	3.37e-04	193	109	6	6646_DN
Drug	Suramin sodium salt; Down 200; 10uM; PC3; HT_HG-U133A	CASP10 ZZEF1 USP19 STK4 TRAFD1 MRTFA	3.47e-04	194	109	6	7529_DN
Drug	ICI 182,780; Down 200; 1uM; HL60; HT_HG-U133A	ZHX3 PEX6 LRRK1 STK4 TSR1 MRTFA	3.47e-04	194	109	6	6165_DN
Drug	5213008; Up 200; 18uM; MCF7; HT_HG-U133A_EA	GAD1 SH2B3 SLC35C1 TXNIP MAFF SAMD4A	3.47e-04	194	109	6	898_UP
Drug	Idoxuridine [54-42-2]; Down 200; 11.2uM; MCF7; HT_HG-U133A	IL11 USP19 GDPD5 SMPD2 RERE RAB11FIP3	3.47e-04	194	109	6	1480_DN
Drug	Betamethasone [378-44-9]; Up 200; 10.2uM; MCF7; HT_HG-U133A	ZHX3 AMPD3 SLC35C1 F5 IKZF5 GDPD5	3.47e-04	194	109	6	5328_UP
Drug	Acetylsalicylsalicylic acid [530-75-6]; Up 200; 13.4uM; MCF7; HT_HG-U133A	IL11 GAD1 BRF1 OGDHL KLK2 MRTFA	3.47e-04	194	109	6	2223_UP
Drug	(S)-propranolol hydrochloride [4199-10-4]; Up 200; 13.6uM; MCF7; HT_HG-U133A	ZZEF1 PPP4R4 CASD1 BRF1 OGDHL MAFF	3.56e-04	195	109	6	5444_UP
Drug	S(-)Eticlopride hydrochloride [97612-24-3]; Up 200; 10.6uM; PC3; HT_HG-U133A	CASP10 IKZF5 VCAN LRP1 CACNA1G SAMD4A	3.56e-04	195	109	6	4634_UP
Drug	Gibberellic acid [77-06-5]; Down 200; 11.6uM; PC3; HT_HG-U133A	AMPD3 USP19 IKZF5 STK4 VCAN LRP1	3.56e-04	195	109	6	4234_DN
Drug	Mephenytoin [50-12-4]; Down 200; 18.4uM; MCF7; HT_HG-U133A	MPP3 WDR4 USP19 BRF1 ZMYM6 RAB11FIP3	3.56e-04	195	109	6	3580_DN
Drug	Testosterone propionate [57-85-2]; Down 200; 11.6uM; PC3; HT_HG-U133A	ZNF671 RGS7 LRP1 SMPD2 WIPI2 RAB11FIP3	3.56e-04	195	109	6	4676_DN
Drug	Bambuterol hydrochloride [81732-46-9]; Up 200; 10uM; MCF7; HT_HG-U133A	MPP3 WDR4 BRF1 OGDHL RERE SAMD4A	3.56e-04	195	109	6	3199_UP
Drug	Acetaminophen [103-90-2]; Up 200; 26.4uM; HL60; HT_HG-U133A	IMPG1 LRP1 CACNA1G CDH5 WIPI2 SAMD4A	3.66e-04	196	109	6	3025_UP
Drug	Dequalinium dichloride [522-51-0]; Up 200; 7.6uM; HL60; HT_HG-U133A	ZNF671 PEX6 LRRK1 PLA2G15 NMT2 VCAN	3.66e-04	196	109	6	1276_UP
Drug	Ribostamycin sulfate salt [53797-35-6]; Up 200; 7.2uM; PC3; HT_HG-U133A	MPP3 IL11 GAD1 SLC35C1 BRF1 SMPD2	3.66e-04	196	109	6	7123_UP
Drug	Miconazole [22916-47-8]; Down 200; 9.6uM; PC3; HT_HG-U133A	WDR4 SH2B3 SLC35C1 LRRK1 TRAFD1 MRTFA	3.66e-04	196	109	6	6615_DN
Drug	Estrone [53-16-7]; Up 200; 14.8uM; PC3; HT_HG-U133A	PPP4R4 BRF1 RERE MRTFA SAMD4A NPAS1	3.66e-04	196	109	6	6647_UP
Drug	Lactobionic acid [96-82-2]; Down 200; 11.2uM; PC3; HT_HG-U133A	GAD1 WDR4 IKZF5 STK4 PDE8B NOTCH1	3.66e-04	196	109	6	6605_DN
Drug	Meticrane [1084-65-7]; Up 200; 14.6uM; HL60; HT_HG-U133A	IL11 RET IKZF5 SMPD2 WIPI2 MRTFA	3.66e-04	196	109	6	1834_UP
Drug	Carisoprodol [78-44-4]; Down 200; 15.4uM; PC3; HT_HG-U133A	SLC35C1 USP19 IKZF5 STK4 LRP1 MAFF	3.66e-04	196	109	6	6610_DN
Drug	Dimethadione [695-53-4]; Up 200; 31uM; HL60; HT_HG-U133A	MPP3 IL11 F5 ATP10A LRP1 SAMD4A	3.66e-04	196	109	6	3029_UP
Drug	Gallamine triethiodide [65-29-2]; Up 200; 4.4uM; MCF7; HT_HG-U133A	IL11 F5 VCAN WIPI2 MRTFA SAMD4A	3.66e-04	196	109	6	2221_UP
Drug	PHA-00851261E [724719-49-7]; Down 200; 10uM; MCF7; HT_HG-U133A	IL11 GAD1 USP19 KCNQ3 MAFF RERE	3.66e-04	196	109	6	3965_DN
Drug	Lumicolchicine gamma [6901-14-0]; Up 200; 10uM; HL60; HT_HG-U133A	PEX6 IKZF5 GDPD5 BRF1 SMPD2 MAFF	3.66e-04	196	109	6	1317_UP
Drug	Diazoxide [364-98-7]; Up 200; 17.4uM; PC3; HT_HG-U133A	IFNAR2 TRAFD1 LRP1 CACNA1G WIPI2 RAB11FIP3	3.66e-04	196	109	6	2052_UP
Drug	fluphenazine dihydrochloride; Down 200; 10uM; HL60; HT_HG-U133A	CASP10 PLA2G15 STK4 CACNA1G SMPD2 MX2	3.66e-04	196	109	6	2697_DN
Drug	Demecarium bromide [56-94-0]; Down 200; 5.6uM; PC3; HT_HG-U133A	IL11 USP19 STK4 BRF1 PDE8B VCAN	3.66e-04	196	109	6	5795_DN
Drug	PF-00539745-00 [351321-33-0]; Up 200; 10uM; PC3; HT_HG-U133A	ZHX3 STK4 VCAN LRP1 RERE MX2	3.66e-04	196	109	6	5979_UP
Drug	Cetirizine dihydrochloride [83881-52-1]; Down 200; 8.6uM; PC3; HT_HG-U133A	LRRK1 ZZEF1 PDE8B VCAN MRTFA RAB11FIP3	3.76e-04	197	109	6	4231_DN
Disease	Intellectual Disability	WDR4 RTTN BRSK2 PEX6 SIN3A METTL23 RGS7 BRF1 CACNA1G ZMYM6	5.02e-06	447	106	10	C3714756
Disease	No-Reflow Phenomenon	JUP CDH5	3.83e-05	3	106	2	C0232347
Disease	Slow-Flow Phenomenon	JUP CDH5	3.83e-05	3	106	2	C2713615
Disease	Familial thoracic aortic aneurysm and aortic dissection	EMILIN1 VCAN PKD1 NOTCH1	4.02e-05	53	106	4	C4707243
Disease	Lafora disease (implicated_via_orthology)	NHLRC1 GYS1	7.63e-05	4	106	2	DOID:3534 (implicated_via_orthology)
Disease	Vitelliform Macular Dystrophy	BEST1 IMPG1	7.63e-05	4	106	2	C0339510
Disease	Juvenile-Onset Vitelliform Macular Dystrophy	BEST1 IMPG1	7.63e-05	4	106	2	C2745945
Disease	Adult-Onset Vitelliform Macular Dystrophy	BEST1 IMPG1	7.63e-05	4	106	2	C1842914
Disease	vitelliform macular dystrophy (is_implicated_in)	BEST1 IMPG1	1.27e-04	5	106	2	DOID:0050661 (is_implicated_in)
Disease	Profound Mental Retardation	PEX6 SIN3A METTL23 RGS7 CACNA1G	1.49e-04	139	106	5	C0020796
Disease	Mental Retardation, Psychosocial	PEX6 SIN3A METTL23 RGS7 CACNA1G	1.49e-04	139	106	5	C0025363
Disease	Mental deficiency	PEX6 SIN3A METTL23 RGS7 CACNA1G	1.49e-04	139	106	5	C0917816
Disease	Acute lymphocytic leukemia	SH2B3 NOTCH1	2.65e-04	7	106	2	C0023449
Disease	platelet component distribution width	MPP3 PRUNE2 SH2B3 RTTN SIN3A ZZEF1 BRF1 GCC2 FGD3 RAB11FIP3	3.97e-04	755	106	10	EFO_0007984
Disease	cancer (implicated_via_orthology)	SIN3A RET STK4 JUP PIPSL NOTCH1	4.24e-04	268	106	6	DOID:162 (implicated_via_orthology)
Disease	white matter microstructure measurement	IL11 AMPD3 DCDC1 SH2B3 BRSK2 ANKHD1 VCAN	5.30e-04	390	106	7	EFO_0005674
Disease	intracranial aneurysm (is_implicated_in)	VCAN PKD1	8.24e-04	12	106	2	DOID:10941 (is_implicated_in)
Disease	rotator cuff tear	CATSPER3 ZNF804A	8.24e-04	12	106	2	EFO_1001250
Disease	Connective Tissue Diseases	PKD1 NOTCH1	9.72e-04	13	106	2	C0009782
Disease	developmental and epileptic encephalopathy (implicated_via_orthology)	KCNQ3 MX2	9.72e-04	13	106	2	DOID:0112202 (implicated_via_orthology)
Disease	Acute Cerebrovascular Accidents	SH2B3 F5 RGS7	9.78e-04	54	106	3	C0751956
Disease	Colorectal Carcinoma	ERICH1 RET F5 ZNF804A EFEMP1 BRF1 PTPRD LRP1 CDH5	9.80e-04	702	106	9	C0009402
Disease	loneliness measurement	NHLRC1 ZNF804A PTPRD RERE	1.06e-03	124	106	4	EFO_0007865
Disease	unipolar depression	ZHX3 ITGA11 DCDC1 RASGEF1A ZNF804A RGS7 PTPRD VCAN PKD1 KCNQ3 RERE FGF19	1.32e-03	1206	106	12	EFO_0003761
Disease	Cerebrovascular accident	SH2B3 F5 RGS7	1.46e-03	62	106	3	C0038454
Disease	Spermatogenic Failure, Nonobstructive, Y-Linked	HSFY1 CDY1	1.48e-03	16	106	2	C1839071
Disease	Spermatogenic failure, Y-linked, 2	HSFY1 CDY1	1.48e-03	16	106	2	cv:C1839071
Disease	SPERMATOGENIC FAILURE, Y-LINKED, 2	HSFY1 CDY1	1.48e-03	16	106	2	415000
Disease	pelvic organ prolapse	EFEMP1 PTPRD SBF2 MAFF	1.49e-03	136	106	4	EFO_0004710
Disease	waist-hip ratio	PRUNE2 ZHX3 AMPD3 ITGA11 ZZEF1 CFAP65 PTPRD PDE8B SBF2 PKD1 RERE PIPSL	1.51e-03	1226	106	12	EFO_0004343
Disease	cervical artery dissection	ZNF804A LRP1	1.68e-03	17	106	2	EFO_1000059
Disease	phospholipids:total lipids ratio, intermediate density lipoprotein measurement	AMPD3 SPG11 TP53BP1	1.83e-03	67	106	3	EFO_0008595, EFO_0020946
Disease	venous thromboembolism, fibrinogen measurement	SH2B3 F5 TRAFD1	1.83e-03	67	106	3	EFO_0004286, EFO_0004623
Disease	Manic Disorder	GAD1 STK4 STARD9	2.16e-03	71	106	3	C0024713
Disease	Colonic Neoplasms	POLB F5 NOTCH1 TP53BP1	2.24e-03	152	106	4	C0009375
Disease	acetate measurement	SH2B3 SPG11	2.33e-03	20	106	2	EFO_0010112
Disease	Malignant tumor of colon	POLB F5 NOTCH1 TP53BP1	2.63e-03	159	106	4	C0007102
Disease	alcohol consumption measurement, high density lipoprotein cholesterol measurement	MPP3 SH2B3 MAFF TP53BP1	2.82e-03	162	106	4	EFO_0004612, EFO_0007878
Disease	brain infarction, neuritic plaque measurement, Lewy body dementia, cerebral amyloid angiopathy, neurofibrillary tangles measurement	ATP10A PTPRD	2.82e-03	22	106	2	EFO_0004277, EFO_0006790, EFO_0006792, EFO_0006797, EFO_0006798
Disease	Manic	GAD1 STK4 STARD9	2.82e-03	78	106	3	C0338831
Disease	Depression, Bipolar	GAD1 STK4 STARD9	2.92e-03	79	106	3	C0005587
Disease	alcohol drinking, high density lipoprotein cholesterol measurement	MPP3 SH2B3 MAFF TP53BP1	3.21e-03	168	106	4	EFO_0004329, EFO_0004612

Protein segments in the cluster

Peptide	Gene	Start	Entry
ELLDRLASHSMLPSD	ERICH1	371	Q86X53
LIDPLAANGTTDMHT	CDY1	231	Q9Y6F8
LSHTDPMVLDDFGTS	CATSPER3	331	Q86XQ3
RMSDLSVIGHPIDSE	VCAN	1336	P13611
MSLPEDEGHTRTLDT	BRD7	481	Q9NPI1
EPTNHLDMETIEALG	ABCF3	636	Q9NUQ8
LSESDGALMEHPEVS	BEST1	516	O76090
SNPRVVDDDGMTSLH	ANKRD39	121	Q53RE8
GTVLAMDPDAARHSI	CDH5	391	P33151
SMPVREHTLLEGLSA	ATP10A	1376	O60312
VDMSHILALITDGPT	AMPD3	256	Q01432
GTSDEHMATIEALRP	NUBP2	136	Q9Y5Y2
ELPGSEHIEMLANAT	PLA2G15	386	Q8NCC3
LHQSGALTMEALEDP	RAB11FIP3	436	O75154
LHTGSIPLDESSSDM	INO80	1366	Q9ULG1
LACESRVSDHMDLGP	NPAS1	316	Q99742
SELLHMLESPESLRS	PABPC1	591	P11940
THLMPEGSLEETGEL	DCDC1	831	M0R2J8
DSSHDLMLLRLSEPA	KLK2	116	P20151
TDLDARMHDGTTPLI	NOTCH1	1986	P46531
HTFPGDSDLRSMIEE	HSFY1	31	Q96LI6
ELSENTPHLSDEALM	MAFF	16	Q9ULX9
TPHLSDEALMGLSVR	MAFF	21	Q9ULX9
NIHTETPLLDLMSDA	NMT2	426	O60551
RSLLHLPDSSMGEEQ	SBF2	1701	Q86WG5
EDSDMLHTPGAASDR	LRRK1	1876	Q38SD2
AASDRSEHDLTPMDG	LRRK1	1886	Q38SD2
VRHLDEMDLSDTPAP	IMPG1	516	Q17R60
ERETVITMSGDDHPR	LRP1	2321	Q07954
DPLFLDLMGTCHSDS	CFAP65	551	Q6ZU64
VATDMLSEHPLLSEP	KIAA1109	2331	Q2LD37
SDTPLSLMSVNHEEL	KCNQ3	786	O43525
SLMSVNHEELERSPS	KCNQ3	791	O43525
EDIDPDVLDSMHSLG	BRSK2	296	Q8IWQ3
MEGFNLELSDHPESL	GAD1	151	Q99259
ADGDHNLDSLPTLAM	IL11	66	P20809
IPEDMLTHIGSVASS	OGDHL	596	Q9ULD0
HDLEEGLEPGSSALM	PEX6	931	Q13608
DEDPHTSDLVGGLMT	PDE8B	496	O95263
PEDLRGHLESDMFSS	FGF19	176	O95750
GHLESDMFSSPLETD	FGF19	181	O95750
PMDSDDSHGSVLRLS	NAXD	221	Q8IW45
DIAESTLPGRHTVEM	METTL23	166	Q86XA0
SLDGVPFLMHDTTLR	GDPD5	266	Q8WTR4
SPTVLGAHAEMALDS	FGD3	101	Q5JSP0
MIVITDGESHDSPDL	ITGA11	266	Q9UKX5
HPSVEVSLDENSGML	IKZF5	56	Q9H5V7
IDAEGASAPLMELLH	JUP	621	P14923
GHTGLPDLSSMTEEE	PIPSL	756	A2A3N6
DDLEAPLMLSSHLEE	IFNAR2	441	P48551
GTPLSDHEALMATLF	SMPD2	266	O60906
ILHMALTGASDPSAE	SLC35C1	11	Q96A29
DLDSSGTHGSEMLPA	ICE1	991	Q9Y2F5
MESLDGLHLPESSRE	CASD1	266	Q96PB1
GLHLPESSRETTAMI	CASD1	271	Q96PB1
TAAASMDSELHPLLV	BTAF1	1091	O14981
CSLALTDDSLPDDMH	CACNA1G	1996	O43497
TDDSLPDDMHTLLLS	CACNA1G	2001	O43497
PDDMHTLLLSALESN	CACNA1G	2006	O43497
DLPLLDMHTVTREEG	GCC2	1501	Q8IWJ2
VHDPMAALETLLTLG	CUTC	151	Q9NTM9
EERLPHGSMSRLTDH	FZD3	606	Q9NPG1
SSDEALIPIREIMSH	CASP10	366	Q92851
ETGDEHPSMNRLTDA	CA7	151	P43166
DLVMGQLAHSEEPLT	EMILIN1	986	Q9Y6C2
MTLFSDSARLHPGEI	ESRG	1	Q1W209
RGHMDLSSSEPSQDI	C1orf127	471	Q8N9H9
EAEMLRSISFHPSGD	CSTF1	216	Q05048
HNMLDDSSDPILTTI	GYS1	446	P13807
STHHPGLLDTLIEMN	DNAH2	1496	Q9P225
MTHLPELDTLSSERA	SEC24B	1196	O95487
ESSGDMDVLLTHPSF	POLB	186	P06746
MAAEASESGPALHEL	NHLRC1	1	Q6VVB1
SESGPALHELMREAE	NHLRC1	6	Q6VVB1
PTQDTHMETDLLSSL	PKD1	3486	P98161
TEHDMIISGLQPETS	PTPRD	781	P23468
MHIAALASAILSDPE	NOC3L	216	Q8WTT2
MPVLSEDSGLHETLA	MPP3	1	Q13368
SGPREHIVDLEMLTV	EFEMP1	456	Q12805
MGHIDLPELETEDTL	RTTN	356	Q86VV8
TIEDPVEALHLGTLM	RGS7	71	P49802
IDDMSKLTLSEGHPE	PRUNE2	2316	Q8WUY3
HLPEILELMSTGGES	PPP4R4	456	Q6NUP7
DLHIMDSLELPTGDP	MRPL4	186	Q9BYD3
DSLMGLSNSHPVEES	TRAFD1	351	O14545
PISSHVDLGLLAEMT	SPATA5L1	386	Q9BVQ7
DPRVAHMVDSSTLAG	TMEM132E	636	Q6IEE7
RHEDTLTLFPMRGES	F5	636	P12259
PTNLHLSVSMDRDTD	RECQL4	671	O94761
MNSDTTSPELREHLA	SIN3A	1106	Q96ST3
TVDHNLLGSEEPTEM	SECISBP2L	591	Q93073
PDSLDDADALGSMLI	SMN1	251	Q16637
SALRLDEDSEHPPMI	WIPI2	436	Q9Y4P8
IHAERMASLTSDPLA	RERE	1401	Q9P2R6
SSLPHLMALEDDVLS	STARD9	476	Q9P2P6
EPSSTMGLDLADGHL	MRTFA	871	Q969V6
GLVMDEHLVASRTPE	TDGF1	151	P13385
STPLMEASQEGHLEL	ANKHD1	536	Q8IWZ3
ALASGEASMEDLHPE	SPG11	1916	Q96JI7
MAVLDTDLDHILPSS	TMTC4	1	Q5T4D3
DTGLDSVATRTPMEH	USP19	436	O94966
AVRAHGPMAELTDSA	ZNF671	31	Q8TAW3
TSARPGDLHVVLDMA	TSR1	136	Q2NL82
ISGSLEALMEHLVPT	RASGEF1A	46	Q8N9B8
MDSSPDEALVHLLAG	REV3L	406	O60673
HLSVTEAEMLRDPEG	TEDC1	211	Q86SX3
TGRGLESTEAEMHIP	SH2B3	306	Q9UQQ2
PKMESLSSHRIDEDG	TP53BP1	526	Q12888
RTEGTPHMLLDLSDL	BRF1	141	Q92994
SSLDHPDERALTMGD	RET	836	P07949
TILCEEMGSEHVSLP	ZMYM6	1051	O95789
VSEDILELSGPAHMT	ZZEF1	2636	O43149
EHDDTLPSQLGTMVI	STK4	356	Q13043
ELGHLSMLLDVAVSP	WDR4	141	P57081
DHRLESPTTPLLDDM	TXNIP	341	Q9H3M7
RAMIPGDHSSIIIDS	ZHX3	556	Q9H4I2
GLVMDEHLVASRTPE	TDGF1P3	151	P51864
IHPATSLEDRSALAM	SAMD4A	131	Q9UPU9
DLEHMPSGESLGRAT	ULK3	271	Q6PHR2
LLPSETNGETEHLEM	ZNF804A	886	Q7Z570
HGASAAELTSMELPV	PP2D1	211	A8MPX8
DSSHDLMLLRLSEPA	KLK3	116	P07288
LSMAHEVDPEGDRTI	MX2	276	P20592