Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcesscanonical Wnt signaling pathway

FZD9 BCL9L LMX1A TLE3 NR4A2 BCL9 LEF1 SOX13

2.12e-05344708GO:0060070
GeneOntologyCellularComponentbeta-catenin-TCF complex

BCL9L TLE3 BCL9 LEF1

1.19e-0713774GO:1990907
GeneOntologyCellularComponentP-body

TNRC6B TOP1 YTHDF2 YTHDF3

5.50e-04102774GO:0000932
GeneOntologyCellularComponentmethyltransferase complex

NCOA6 KMT2D WDR4 ZC3H13

6.82e-04108774GO:0034708
GeneOntologyCellularComponentMLL3/4 complex

NCOA6 KMT2D

8.63e-0412772GO:0044666
HumanPhenoLarge earlobe

KMT2D WDR4 SLC26A2 TRIP12

3.14e-0537264HP:0009748
HumanPhenoAbnormal earlobe morphology

KMT2D PTPRF WDR4 SLC26A2 TRIP12 AHDC1

5.01e-05137266HP:0000363
MousePhenoabnormal dentate gyrus morphology

FZD9 KMT2D PIANP TRIO LEF1

2.78e-0586585MP:0000812
DomainNPIP

NPIPB13 NPIPA5 NPIPA1 NPIPB3 NPIPA3 NPIPB5 NPIPA7 NPIPA2 NPIPB2

3.69e-1914769IPR009443
DomainBCL9_beta-catenin-bd_dom

BCL9L BCL9

1.63e-052762IPR024670
DomainBCL9

BCL9L BCL9

1.63e-052762PF11502
DomainBcl-9

BCL9L BCL9

1.63e-052762IPR015668
DomainYTH_domain

YTHDF2 YTHDF3

1.62e-045762IPR007275
DomainYTH

YTHDF2 YTHDF3

1.62e-045762PS50882
DomainYTH

YTHDF2 YTHDF3

1.62e-045762PF04146
DomainGP_PDE_dom

GDPD4 GDPD2

3.39e-047762IPR030395
DomainGlyceroP-diester-Pdiesterase

GDPD4 GDPD2

3.39e-047762IPR004129
DomainGP_PDE

GDPD4 GDPD2

3.39e-047762PS51704
DomainGDPD

GDPD4 GDPD2

3.39e-047762PF03009
Domainzf-CCCH

MBNL2 ZC3H13 ZC3HAV1

1.04e-0349763PF00642
DomainWWE

TRIP12 ZC3HAV1

1.05e-0312762PS50918
DomainWWE

TRIP12 ZC3HAV1

1.05e-0312762PF02825
DomainWWE-dom

TRIP12 ZC3HAV1

1.05e-0312762IPR004170
DomainHMG_box

KMT2D LEF1 SOX13

1.31e-0353763PF00505
DomainHMG

KMT2D LEF1 SOX13

1.38e-0354763SM00398
Domain-

KMT2D LEF1 SOX13

1.46e-03557631.10.30.10
DomainLaminin_G

EYS NRXN2 COL22A1

1.70e-0358763IPR001791
DomainZnf_CCCH

MBNL2 ZC3H13 ZC3HAV1

1.70e-0358763IPR000571
DomainZF_C3H1

MBNL2 ZC3H13 ZC3HAV1

1.70e-0358763PS50103
DomainHMG_box_dom

KMT2D LEF1 SOX13

2.36e-0365763IPR009071
Domain-

GDPD4 GDPD2

4.61e-03257623.20.20.190
DomainPLC-like_Pdiesterase_TIM-brl

GDPD4 GDPD2

4.61e-0325762IPR017946
DomainCRAL-TRIO_dom

TRIO PLEKHG4

5.77e-0328762IPR001251
DomainZnF_U1

ZMAT3 ZFHX2

6.18e-0329762SM00451
DomainZnf_U1

ZMAT3 ZFHX2

6.18e-0329762IPR003604
PathwayREACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX

BCL9L KMT2D TLE3 BCL9 LEF1 SOX13

9.98e-0942536M27272
PathwayREACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX

BCL9L KMT2D TLE3 BCL9 LEF1

3.84e-0826535MM14793
PathwayREACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX

BCL9L KMT2D TLE3 BCL9 LEF1

2.25e-0591535M27101
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

BCL9L KMT2D TLE3 BCL9 LEF1 SOX13

2.68e-05158536MM14791
PathwayREACTOME_SIGNALING_BY_WNT

BCL9L KMT2D TLE3 TNRC6B BCL9 LEF1 SOX13

2.21e-04330537M7847
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

BCL9L KMT2D TLE3 BCL9 LEF1 SOX13

2.29e-04233536M27099
PathwayREACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX

TLE3 LEF1 SOX13

2.30e-0432533MM14975
PathwayREACTOME_SIGNALING_BY_WNT

BCL9L KMT2D TLE3 BCL9 LEF1 SOX13

2.63e-04239536MM14756
PathwayREACTOME_REPRESSION_OF_WNT_TARGET_GENES

TLE3 LEF1

6.12e-0410532MM15156
Pubmed

Novel retinal and cone photoreceptor transcripts revealed by human macular expression profiling.

NPIPA5 NPIPA1 NPIPA3 NPIPA2

3.48e-11486418055785
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

BCL9L NCOA6 TNRC18 KMT2D RBM12 GSE1 TLE3 USP7 BCL9 ZNF281 AHDC1

6.80e-11268861133640491
Pubmed

Interaction network of human early embryonic transcription factors.

BCL9L NCOA6 TNRC18 KMT2D HDAC5 GSE1 TLE3 BCL9 ZNF281 SOX13 AHDC1 YTHDF3

7.25e-11351861238297188
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

ATXN2L LIG1 NCOA6 KMT2D GSE1 USP42 ACLY TLE3 ZC3H13 USP7 BCL9 TRIP12 SF3B2 ZC3HAV1

6.72e-09774861415302935
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

BCL9L NCOA6 KMT2D RBM12 GSE1 TLE3 TNRC6B BCL9 AHDC1 YTHDF2 YTHDF3

1.81e-08457861132344865
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

ZMAT3 BCL9L LIG1 KMT2D HDAC5 USP42 USP7 OBSL1 ZNF281 TRIP12 AHDC1

2.35e-08469861127634302
Pubmed

Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.

NCOA6 KMT2D GSE1 TLE3 BCL9 ZNF281

6.21e-088386628794006
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

NCOA6 KMT2D ACLY FAM186A USP7 TRIP12 SF3B2 ZC3HAV1

1.26e-0723486836243803
Pubmed

Human transcription factor protein interaction networks.

BCL9L NCOA6 KMT2D RBM12 HDAC5 GSE1 TLE3 USP7 TNRC6B BCL9 ZNF281 SOX13 TOP1 YTHDF2 YTHDF3 ZC3HAV1

3.88e-071429861635140242
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

ATXN2L LIG1 NCOA6 TNRC18 KMT2D RBM12 GSE1 ACLY TLE3 INPP5D BCL9 ZNF281 AHDC1 TOP1

5.20e-071103861434189442
Pubmed

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.

RALGAPA1 ATXN2L ACLY ZC3H13 ZNF281 YTHDF2 YTHDF3

6.19e-0719786720811636
Pubmed

Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9.

BCL9L TLE3 BCL9

8.10e-07886328296634
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

NCOA6 RBM12 HDAC5 NRXN2 AMOT OBSL1 TNRC6B

1.50e-0622586712168954
Pubmed

Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping.

NCOA6 KMT2D GSE1 TLE3 TOP1

1.51e-067886528611094
Pubmed

Identification of proximal SUMO-dependent interactors using SUMO-ID.

RBM12 TLE3 USP7 TNRC6B ZNF281 AHDC1 YTHDF2 YTHDF3 ZC3HAV1

1.60e-0644486934795231
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

ATXN2L MBNL2 AMOT ACLY TNRC6B ZNF281 TRIP12 TOP1 YTHDF2 YTHDF3 ZC3HAV1

1.75e-06724861136232890
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

ATXN2L NCOA6 KMT2D GSE1 TLE3 ZNF281 TOP1 SF3B2

2.15e-0634186832971831
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

ATXN2L NCOA6 TNRC18 ACLY USP7 TNRC6B ZNF281 LEF1 TRIP12 AHDC1 TOP1 SF3B2 YTHDF3 ZC3HAV1

2.20e-061247861427684187
Pubmed

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

ATXN2L RBM12 GSE1 AMOT TNRC6B BCL9

2.22e-0615286638360978
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

ATXN2L RBM12 ANK2 GSE1 ACLY USP7 TNRC6B ZNF281 TOP1 SF3B2 YTHDF2 ZC3HAV1

3.24e-06934861233916271
Pubmed

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.

NCOA6 KMT2D ZNF281

4.10e-061386317761849
Pubmed

Alternative splice variants encoding unstable protein domains exist in the human brain.

HDAC5 PTPRF NRXN2

4.10e-061386315491607
Pubmed

Dose-Dependent and Subset-Specific Regulation of Midbrain Dopaminergic Neuron Differentiation by LEF1-Mediated WNT1/b-Catenin Signaling.

LMX1A NR4A2 LEF1

5.21e-061486333195246
Pubmed

Trip12 is an E3 ubiquitin ligase for USP7/HAUSP involved in the DNA damage response.

USP7 TRIP12

6.04e-06286227800609
Pubmed

Positive selection of a gene family during the emergence of humans and African apes.

NPIPA1 NPIPA8

6.04e-06286211586358
Pubmed

Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell (cDC1) activation and tumor infiltration.

BCL9L BCL9

6.04e-06286238811552
Pubmed

Striking a balance: regulation of transposable elements by Zfp281 and Mll2 in mouse embryonic stem cells.

KMT2D ZNF281

6.04e-06286229036642
Pubmed

YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways.

YTHDF2 YTHDF3

6.04e-06286232905781
Pubmed

Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions.

BCL9L BCL9

6.04e-06286215371335
Pubmed

Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas.

BCL9L BCL9

6.04e-06286220682801
Pubmed

The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains.

PTPRF TRIO

6.04e-0628628643598
Pubmed

BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer.

BCL9L BCL9

6.04e-06286233767438
Pubmed

The nuclear interactome of DYRK1A reveals a functional role in DNA damage repair.

RALGAPA1 LIG1 KMT2D PEX19 TRIP12

6.84e-0610686531024071
Pubmed

Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.

ATXN2L TNRC6B YTHDF2 YTHDF3 ZC3HAV1

7.17e-0610786530995489
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

ONECUT2 NRXN2 USP42 WDR7 ZC3H13 USP7 TNRC6B ZNF281 TRIP12 AHDC1 TOP1 SF3B2

1.42e-051082861238697112
Pubmed

YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA.

YTHDF2 YTHDF3

1.81e-05386228106072
Pubmed

Isolation and characterization of two serpentine membrane proteins containing glycerophosphodiester phosphodiesterase, GDE2 and GDE6.

GDPD4 GDPD2

1.81e-05386215276213
Pubmed

YTHDF2 suppresses the plasmablast genetic program and promotes germinal center formation.

YTHDF2 YTHDF3

1.81e-05386235508130
Pubmed

YTH: a new domain in nuclear proteins.

YTHDF2 YTHDF3

1.81e-05386212368078
Pubmed

A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA.

YTHDF2 YTHDF3

1.81e-05386232492408
Pubmed

The interactions of Bcl9/Bcl9L with β-catenin and Pygopus promote breast cancer growth, invasion, and metastasis.

BCL9L BCL9

1.81e-05386234545187
Pubmed

Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells.

BCL9L BCL9

1.81e-05386233649334
Pubmed

m6A enhances the phase separation potential of mRNA.

YTHDF2 YTHDF3

1.81e-05386231292544
Pubmed

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq.

YTHDF2 YTHDF3

1.81e-05386222575960
Pubmed

Comprehensive Analysis of YTH Domain Family in Lung Adenocarcinoma: Expression Profile, Association with Prognostic Value, and Immune Infiltration.

YTHDF2 YTHDF3

1.81e-05386234497675
Pubmed

m6A modification controls the innate immune response to infection by targeting type I interferons.

YTHDF2 YTHDF3

1.81e-05386230559377
Pubmed

Divergent origins and concerted expansion of two segmental duplications on chromosome 16.

NPIPB3 NPIPB5

1.81e-05386211948212
Pubmed

m6A-binding YTHDF proteins promote stress granule formation.

YTHDF2 YTHDF3

1.81e-05386232451507
Pubmed

USP7 sustains an active epigenetic program via stabilizing MLL2 and WDR5 in diffuse large B-cell lymphoma.

KMT2D USP7

1.81e-05386235411950
Pubmed

Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor.

BCL9L BCL9

1.81e-05386220637214
Pubmed

Functional roles of Nurr1, Pitx3, and Lmx1a in neurogenesis and phenotype specification of dopamine neurons during in vitro differentiation of embryonic stem cells.

LMX1A NR4A2

1.81e-05386224172139
Pubmed

N(6)-methyladenosine of HIV-1 RNA regulates viral infection and HIV-1 Gag protein expression.

YTHDF2 YTHDF3

1.81e-05386227371828
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

KMT2D RBM12 GSE1 ACLY USP7 SF3B2

1.85e-0522086635785414
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

RALGAPA1 ATXN2L MBNL2 ZC3H13 OBSL1 TNRC6B YTHDF2 YTHDF3

1.96e-0546286831138677
Pubmed

MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.

HDAC5 GSE1 TLE3 USP7 ZNF281 TOP1 SF3B2

2.18e-0533986730415952
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

LIG1 NCOA6 INCENP TRIO TLE3 USP7 TNRC6B YTHDF3

2.28e-0547286838943005
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

ATXN2L NCOA6 INCENP MBNL2 ZC3H13 ZNF281 TRIP12 TOP1 SF3B2 YTHDF2 YTHDF3

2.34e-05954861136373674
Pubmed

BCOR modulates transcriptional activity of a subset of glucocorticoid receptor target genes involved in cell growth and mobility.

GSE1 TLE3 USP7

2.85e-052486333722704
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

ONECUT2 ZMAT3 MBNL2 LMX1A TLE3 ZC3H13 LEF1 SOX13 SF3B2 ZC3HAV1

3.12e-05808861020412781
Pubmed

A High-Density Map for Navigating the Human Polycomb Complexome.

NCOA6 KMT2D L3MBTL1 GSE1 USP7 ZNF281 TRIP12 AHDC1

3.20e-0549586827705803
Pubmed

The Maternal Microbiome Programs the m6A Epitranscriptome of the Mouse Fetal Brain and Intestine.

SOX13 YTHDF2 YTHDF3

3.23e-052586335874829
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

ATXN2L INCENP ACLY ZC3H13 USP7 TRIP12 TOP1 SF3B2 ZC3HAV1

3.49e-0565386922586326
Pubmed

Association of tyrosine phosphatases SHP-1 and SHP-2, inositol 5-phosphatase SHIP with gp49B1, and chromosomal assignment of the gene.

INPP5D LILRB4

3.61e-0548629422771
Pubmed

BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration.

BCL9L BCL9

3.61e-05486219699733
Pubmed

Lmx1a-Dependent Activation of miR-204/211 Controls the Timing of Nurr1-Mediated Dopaminergic Differentiation.

LMX1A NR4A2

3.61e-05486235805964
Pubmed

N6-methyladenosine-dependent regulation of messenger RNA stability.

YTHDF2 YTHDF3

3.61e-05486224284625
Pubmed

Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.

ATXN2L ACLY ZNF281 YTHDF3 ZC3HAV1

3.91e-0515286516009940
Pubmed

Context-dependent functional compensation between Ythdf m6A reader proteins.

YTHDF2 YTHDF3

6.01e-05586232943573
Pubmed

LATS2 suppresses oncogenic Wnt signaling by disrupting β-catenin/BCL9 interaction.

BCL9L BCL9

6.01e-05586224360964
Pubmed

TBX3 acts as tissue-specific component of the Wnt/β-catenin transcriptional complex.

BCL9L BCL9

6.01e-05586232808927
Pubmed

Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models.

BCL9L BCL9

6.01e-05586230760710
Pubmed

Crystal structure of a beta-catenin/BCL9/Tcf4 complex.

BCL9L BCL9

6.01e-05586217052462
Pubmed

Genome-wide ENU mutagenesis in combination with high density SNP analysis and exome sequencing provides rapid identification of novel mouse models of developmental disease.

LIG1 FRAS1

6.01e-05586223469164
Pubmed

LEF1 and B9L shield β-catenin from inactivation by Axin, desensitizing colorectal cancer cells to tankyrase inhibitors.

BCL9 LEF1

6.01e-05586224419084
Pubmed

A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential.

BCL9L BCL9

6.01e-05586219328798
Pubmed

Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.

ATXN2L RBM12 AMOT TLE3 ZC3H13 SF3B2 YTHDF2

6.12e-0539986735987950
Pubmed

Specification of dopaminergic subsets involves interplay of En1 and Pitx3.

LMX1A TLE3 NR4A2

6.24e-053186323863478
Pubmed

mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.

ATXN2L AMOT TOP1 SF3B2 YTHDF2 ZC3HAV1

6.28e-0527486634244482
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

RALGAPA1 ATXN2L ANK2 ACLY TNRC6B TOP1 SF3B2 YTHDF2 ZC3HAV1

6.50e-0570886939231216
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

ATXN2L NCOA6 KMT2D AMOT ACLY USP7 TNRC6B ZC3HAV1

6.61e-0554986838280479
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

FRAS1 HDAC5 GSE1 WDR7 TLE3 OBSL1 TNRC6B

6.93e-0540786712693553
Pubmed

Physiological and pathophysiological characteristics of ataxin-3 isoforms.

ATXN2L AMOT ACLY USP7 SF3B2 YTHDF2

7.22e-0528186630455355
Pubmed

Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta.

ONECUT2 PTPRF NR4A2 BCL9

7.57e-059086415033168
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

ONECUT2 NCOA6 KMT2D USP42 ZC3H13 USP7 ZNF281 TRIP12 AHDC1 TOP1 SF3B2 ZC3HAV1

8.06e-051294861230804502
Pubmed

The functional interactome landscape of the human histone deacetylase family.

TNRC18 HDAC5 GSE1 USP7 TOP1 SF3B2

8.42e-0528986623752268
Pubmed

BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling.

BCL9L BCL9

9.01e-05686217113272
Pubmed

Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating β-catenin-TCF activity.

BCL9 LEF1

9.01e-05686221399610
Pubmed

Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer.

BCL9L BCL9

9.01e-05686230760720
Pubmed

Role of a BCL9-related beta-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling.

BCL9L BCL9

9.01e-05686215574752
Pubmed

Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development.

BCL9L BCL9

9.01e-05686225184676
Pubmed

Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.

NCOA6 KMT2D

9.01e-05686217021013
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

NCOA6 TNRC18 HDAC5 INPP5D USP7 BCL9 TRIP12

9.76e-0543086735044719
Pubmed

The RNA-binding protein Snd1/Tudor-SN regulates hypoxia-responsive gene expression.

ATXN2L AMOT TNRC6B ZC3HAV1

1.01e-049786437151849
Pubmed

Transcriptional network orchestrating regional patterning of cortical progenitors.

LMX1A NR4A2 LEF1

1.25e-043986334921112
Pubmed

A network of high-mobility group box transcription factors programs innate interleukin-17 production.

LEF1 SOX13

1.26e-04786223562159
Pubmed

Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling.

BCL9L BCL9

1.26e-04786230366904
Pubmed

Wnt receptors and Wnt inhibitors are expressed in gradients in the developing telencephalon.

FZD9 LEF1

1.26e-04786211335128
Pubmed

ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.

NCOA6 KMT2D

1.26e-04786219556342
Pubmed

Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase.

NCOA6 TOP1

1.26e-04786212519782
Pubmed

Identification and Functional Characterization of a Novel Androgen Receptor Coregulator, EAP1.

GSE1 TLE3 USP7

1.35e-044086334585037
InteractionEGR2 interactions

BCL9L NCOA6 TNRC18 KMT2D HDAC5 TLE3 BCL9 ZNF281 AHDC1

2.28e-08171799int:EGR2
InteractionALG13 interactions

KMT2D RBM12 GSE1 TLE3 TNRC6B BCL9 YTHDF2 YTHDF3 ZC3HAV1

4.11e-08183799int:ALG13
InteractionSMG7 interactions

NCOA6 KMT2D RBM12 GSE1 AMOT TLE3 TNRC6B BCL9 YTHDF2 YTHDF3 ZC3HAV1

4.56e-083197911int:SMG7
InteractionGATA3 interactions

KMT2D RBM12 HDAC5 GSE1 PLEKHG4 TLE3 USP7 BCL9 ZNF281

4.95e-08187799int:GATA3
InteractionNUP35 interactions

BCL9L NCOA6 KMT2D RBM12 GSE1 TLE3 OBSL1 TNRC6B BCL9 AHDC1 YTHDF2 YTHDF3

9.24e-084247912int:NUP35
InteractionSOX9 interactions

NCOA6 KMT2D HDAC5 TLE3 USP7 BCL9 ZNF281

1.05e-0797797int:SOX9
InteractionERG interactions

NCOA6 KMT2D GSE1 TLE3 BCL9 ZNF281 TRIP12 TOP1 SF3B2

2.23e-07223799int:ERG
InteractionGATA2 interactions

NCOA6 KMT2D HDAC5 GSE1 TLE3 USP7 BCL9 ZNF281

1.12e-06199798int:GATA2
InteractionGSC interactions

BCL9L TNRC18 KMT2D TLE3 BCL9 SOX13

1.17e-0687796int:GSC
InteractionBCOR interactions

FRAS1 L3MBTL1 HDAC5 GSE1 USP42 AMOT TLE3 USP7 ZNF281

2.78e-06302799int:BCOR
InteractionGATA1 interactions

KMT2D RBM12 HDAC5 GSE1 TLE3 USP7 BCL9

4.86e-06171797int:GATA1
InteractionTBXT interactions

NCOA6 KMT2D GSE1 TLE3 BCL9 ZNF281

6.30e-06116796int:TBXT
InteractionGCM1 interactions

KMT2D HDAC5 GSE1 TLE3 BCL9

7.00e-0668795int:GCM1
InteractionKLF5 interactions

NCOA6 KMT2D GSE1 TLE3 BCL9 ZNF281 YTHDF3

1.15e-05195797int:KLF5
InteractionPAX9 interactions

BCL9L NCOA6 KMT2D GSE1 TLE3 BCL9

1.21e-05130796int:PAX9
InteractionFEV interactions

NCOA6 KMT2D GSE1 TLE3 BCL9 ZNF281 SOX13

1.49e-05203797int:FEV
InteractionTLE3 interactions

BCL9L TNRC18 KMT2D RBM12 GSE1 TLE3 BCL9 ZNF281 AHDC1

1.62e-05376799int:TLE3
InteractionMEX3A interactions

BCL9L EYS TNRC18 TRIO PEX19 AHDC1 YTHDF2 YTHDF3 ZC3HAV1

1.91e-05384799int:MEX3A
InteractionSOX15 interactions

KMT2D GSE1 TLE3 BCL9 ZNF281 TOP1

1.93e-05141796int:SOX15
InteractionTLX2 interactions

KMT2D GSE1 TLE3 USP7 BCL9 ZNF281

2.00e-05142796int:TLX2
InteractionPAX2 interactions

KMT2D GSE1 TLE3 USP7 BCL9

2.09e-0585795int:PAX2
InteractionSP7 interactions

BCL9L NCOA6 KMT2D RBM12 GSE1 TLE3 BCL9 ZNF281

2.52e-05304798int:SP7
InteractionCFAP45 interactions

TRIO USP7 OBSL1

2.55e-0515793int:CFAP45
InteractionAR interactions

BCL9L NCOA6 TNRC18 KMT2D RBM12 GSE1 ACLY TLE3 USP7 OBSL1 BCL9 ZNF281 AHDC1 SF3B2

2.79e-059927914int:AR
InteractionNUP43 interactions

BCL9L NCOA6 KMT2D GSE1 INCENP ZC3H13 TNRC6B ZNF281 TRIP12 AHDC1 TOP1

3.12e-056257911int:NUP43
InteractionCTNNB1 interactions

ATXN2L BCL9L KMT2D ANK2 PTPRF AMOT ACLY TLE3 USP7 OBSL1 BCL9 LEF1 TOP1 YTHDF2

3.37e-0510097914int:CTNNB1
InteractionSOX6 interactions

GSE1 TLE3 USP7 ZNF281 TRIP12 SOX13

3.53e-05157796int:SOX6
InteractionPYGO2 interactions

BCL9L KMT2D TLE3 BCL9

3.73e-0548794int:PYGO2
InteractionOTUD4 interactions

TLE3 USP7 OBSL1 TNRC6B YTHDF2 YTHDF3 ZC3HAV1

3.91e-05236797int:OTUD4
InteractionKLF4 interactions

KMT2D HDAC5 USP7 BCL9 ZNF281 ZC3HAV1

3.93e-05160796int:KLF4
InteractionSUZ12 interactions

BCL9L KMT2D USP42 ZC3H13 USP7 OBSL1 ZNF281 TRIP12 AHDC1 TOP1 SF3B2

4.09e-056447911int:SUZ12
InteractionGLI2 interactions

HDAC5 TLE3 USP7 TNRC6B ZNF281

4.37e-0599795int:GLI2
InteractionEYA4 interactions

ATXN2L RBM12 GSE1 AMOT USP7 TNRC6B BCL9

4.71e-05243797int:EYA4
InteractionTSPYL5 interactions

ATXN2L USP7 TOP1 ZC3HAV1

4.75e-0551794int:TSPYL5
InteractionCEP85 interactions

AMOT TNRC6B SOX13 YTHDF2 YTHDF3 ZC3HAV1

5.33e-05169796int:CEP85
InteractionDCP1B interactions

ATXN2L TNRC6B YTHDF2 YTHDF3 ZC3HAV1

5.53e-05104795int:DCP1B
InteractionTPRX2 interactions

NCOA6 KMT2D GSE1 TLE3

6.88e-0556794int:TPRX2
InteractionLHX6 interactions

BCL9L TLE3 USP7 BCL9

7.90e-0558794int:LHX6
InteractionTBR1 interactions

BCL9L KMT2D GSE1 TLE3 BCL9

8.21e-05113795int:TBR1
InteractionUTY interactions

NCOA6 KMT2D USP7

9.70e-0523793int:UTY
InteractionHNF1B interactions

KMT2D GSE1 TLE3 BCL9 ZNF281 SOX13

1.02e-04190796int:HNF1B
InteractionTNRC6A interactions

NCOA6 AMOT TLE3 TNRC6B YTHDF2 YTHDF3 ZC3HAV1

1.14e-04280797int:TNRC6A
InteractionFOXL1 interactions

KMT2D GSE1 TLE3 USP7 BCL9 ZNF281

1.21e-04196796int:FOXL1
InteractionCNOT4 interactions

TLE3 TNRC6B YTHDF2 YTHDF3

1.23e-0465794int:CNOT4
InteractionPAX7 interactions

KMT2D GSE1 TLE3 BCL9 ZNF281

1.27e-04124795int:PAX7
InteractionMCM6 interactions

L3MBTL1 HDAC5 ACLY USP7 OBSL1 TOP1 SF3B2

1.33e-04287797int:MCM6
InteractionTLX3 interactions

BCL9L NCOA6 KMT2D GSE1 TLE3 BCL9 ZNF281

1.45e-04291797int:TLX3
InteractionMAFA interactions

NCOA6 KMT2D USP7

1.58e-0427793int:MAFA
InteractionRBMS1 interactions

ATXN2L MBNL2 TNRC6B YTHDF2 YTHDF3 ZC3HAV1

1.63e-04207796int:RBMS1
InteractionMEN1 interactions

ATXN2L NCOA6 KMT2D GSE1 TLE3 ZC3H13 ZNF281 TRIP12 AHDC1 TOP1 SF3B2 YTHDF3 ZC3HAV1

1.70e-0410297913int:MEN1
InteractionFAM193A interactions

AMOT TLE3 TNRC6B YTHDF3

1.74e-0471794int:FAM193A
InteractionCBX3 interactions

LIG1 L3MBTL1 INCENP ACLY ZC3H13 OBSL1 ZNF281 TRIP12 AHDC1 TOP1

2.10e-046467910int:CBX3
InteractionNFIB interactions

KMT2D GSE1 TLE3 BCL9 ZNF281

2.40e-04142795int:NFIB
InteractionDAZL interactions

ATXN2L MBNL2 TNRC6B YTHDF2 YTHDF3

2.64e-04145795int:DAZL
InteractionCEBPA interactions

ATXN2L LIG1 NCOA6 TNRC18 KMT2D RBM12 GSE1 ACLY TLE3 INPP5D BCL9 ZNF281 AHDC1 TOP1

3.11e-0412457914int:CEBPA
InteractionTERF2 interactions

RALGAPA1 WDR4 ACLY ZC3H13 ZNF281 TOP1 SF3B2

3.74e-04340797int:TERF2
InteractionCTTN interactions

ATXN2L AMOT ACLY USP7 OBSL1 TOP1 SF3B2 YTHDF3

3.79e-04450798int:CTTN
InteractionNAA40 interactions

ATXN2L RBM12 ANK2 GSE1 ACLY USP7 TNRC6B ZNF281 TOP1 SF3B2 YTHDF2 ZC3HAV1

4.05e-049787912int:NAA40
InteractionASF1A interactions

NCOA6 KMT2D GSE1 INCENP ZC3H13 ZNF281

4.38e-04249796int:ASF1A
InteractionFOXI1 interactions

KMT2D GSE1 TLE3 BCL9

4.70e-0492794int:FOXI1
InteractionCNOT6L interactions

VASN TNRC6B YTHDF2 YTHDF3

4.90e-0493794int:CNOT6L
InteractionDCP1A interactions

ATXN2L TNRC6B YTHDF2 YTHDF3 ZC3HAV1

4.92e-04166795int:DCP1A
InteractionSOX17 interactions

NCOA6 KMT2D BCL9 ZNF281

5.31e-0495794int:SOX17
InteractionISL1 interactions

BCL9L LMX1A BCL9

5.55e-0441793int:ISL1
InteractionPAX6 interactions

NCOA6 KMT2D GSE1 WDR4 TLE3 BCL9 ZNF281

5.81e-04366797int:PAX6
InteractionZBTB7B interactions

ATXN2L HDAC5 ZNF281 LEF1 TOP1 YTHDF2 ZC3HAV1

5.81e-04366797int:ZBTB7B
InteractionTLX1 interactions

KMT2D GSE1 TLE3 BCL9 ZNF281

6.25e-04175795int:TLX1
Cytoband16p13.11

NPIPA5 NPIPA1 NPIPA3 NPIPA2

1.09e-072388416p13.11
CytobandEnsembl 112 genes in cytogenetic band chr16p13

VASN NPIPA5 USP7 NPIPA1 NPIPA3 NPIPA7 NPIPA2 NPIPB2

1.73e-06426888chr16p13
Cytoband16p12.2

NPIPB4 NPIPB3 NPIPB5

5.04e-053788316p12.2
CytobandEnsembl 112 genes in cytogenetic band chr16p12

NPIPB4 NPIPB3 NPIPB5 NPIPA8

3.47e-04172884chr16p12
Cytoband18q21.31

ONECUT2 WDR7

4.28e-041688218q21.31
Cytoband16q24.1

ADAD2 GSE1

1.85e-033388216q24.1
CytobandEnsembl 112 genes in cytogenetic band chr16p11

ATXN2L NPIPB13 NPIPB12 NPIPB11

2.06e-03278884chr16p11
Cytoband12q13.12

KMT2D FAM186A

2.44e-033888212q13.12
Cytoband7p22.1

TNRC18 USP42

3.71e-03478827p22.1
GeneFamilyAtaxins|Trinucleotide repeat containing

TNRC18 KMT2D TNRC6B

2.98e-0525443775
GeneFamilyZinc fingers CCCH-type

MBNL2 ZC3H13 ZC3HAV1

8.34e-053544373
GeneFamilyCollagens

COL8A2 COL22A1

5.60e-0346442490
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

PTPRF TRIO OBSL1

7.03e-03161443593
GeneFamilyUbiquitin specific peptidases

USP42 USP7

8.20e-0356442366
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

TRIO PLEKHG4

1.12e-0266442722
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PTPRF NRXN2 TRIO NPIPA5 OBSL1 NPIPA2 NPIPB2

6.01e-08180867e4add4c94f892a2d93926e5c6dac6a738319d091
ToppCell10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8|Liver / Manually curated celltypes from each tissue

RALGAPA1 NPIPB4 MBNL2 TNRC6B LEF1 ZC3HAV1

1.40e-06181866f2315414e714ac86211546a935660c4be6e85f1b
ToppCellnucseq-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-CD4_T|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NPIPB4 TNRC6B NPIPB3 NPIPB5 LEF1 ZC3HAV1

2.04e-061938669c9434a3297b85774b4f0ecab6294f44d738e29f
Diseaseresponse to platinum based chemotherapy, cytotoxicity measurement

FRAS1 EYS

6.69e-055772EFO_0004647, EFO_0006952
DiseaseNeurodevelopmental Disorders

ANK2 TRIO TNRC6B TRIP12

1.05e-0493774C1535926
Diseasevolumetric bone mineral density

MAP4K3 TLE3 FMN2

1.82e-0442773EFO_0007620
Diseaseintracranial aneurysm (is_implicated_in)

KMT2D COL22A1

4.36e-0412772DOID:10941 (is_implicated_in)
Diseasephosphatidylcholine 40:7 measurement

NPIPA1 NPIPA2

5.15e-0413772EFO_0021477
Diseasephotoreceptor cell layer thickness measurement

GDPD4 RALGAPA1 GSE1 ZNF281

6.19e-04148774EFO_0803370
Disease1,3,7-trimethylurate measurement

FRAS1 PTPRF

6.90e-0415772EFO_0021172
DiseaseMuscle hypotonia

RALGAPA1 CHST14

8.91e-0417772C0026827
DiseaseDisproportionate short stature

CHST14 SLC26A2 OBSL1

1.09e-0377773C0878659
Diseaseenergy expenditure measurement

MBNL2 USP7

1.24e-0320772EFO_0008005
Diseasedisease of metabolism (implicated_via_orthology)

YTHDF2 YTHDF3

1.37e-0321772DOID:0014667 (implicated_via_orthology)
Diseaselipid measurement, intermediate density lipoprotein measurement

NPIPA1 NPIPA2 TOP1

2.05e-0396773EFO_0004529, EFO_0008595
Diseasephospholipid measurement, intermediate density lipoprotein measurement

NPIPA1 NPIPA2 TOP1

2.24e-0399773EFO_0004639, EFO_0008595
Diseaseurate measurement

FZD9 NCOA6 HDAC5 PTPRF NRXN2 FMN2 COL22A1 TOP1

2.31e-03895778EFO_0004531

Protein segments in the cluster

PeptideGeneStartEntry
QGMAIPHPSPAKHGP

FAM222A

221

Q5U5X8
NHKKMPVPPGAPQGG

FAM246A

216

A0A494C0Y3
NHKKMPVPPGAPQGG

FAM246B

216

A0A494C0N9
MGKAPRVPVPPAGLS

ADAD2

91

Q8NCV1
KGMEHRGPPPEYPFK

AMOT

231

Q4VCS5
KRVPMGPIIVPPGGH

GSE1

101

Q14687
MKQLFPPPPGTSLTH

ADARB2-AS1

1

A8MUL3
PKSGFLGPMAEPHPE

AHDC1

1581

Q5TGY3
MAGPVPPHPGLAVRA

DANCR

1

P0C864
HMPEPALNPGPKGQP

ADAMTS7

1346

Q9UKP4
PQVMLLHPPQSHGGP

ATXN2L

986

Q8WWM7
GPKQHPEDPIGHPIM

AOX1

571

Q06278
AETLKNRMGHQPPPP

NPIPB3

236

Q92617
FKQNMGPSGQTHPPP

RBM12

391

Q9NTZ6
AETLKNRMGHQPPPP

NPIPA1

236

Q9UND3
AETLKNRMGHQPPPP

NPIPB12

236

F8W0I5
KQGMSRHPPAPDIPT

LEF1

181

Q9UJU2
PKMKAGIFPSHFPLP

ANK2

2476

Q01484
SPPGPPILAEMFKGH

OBSL1

516

O75147
PRLPPHKPVALGNGM

MAP4K3

481

Q8IVH8
PISNGLPPTPKVHMG

MAP4K3

531

Q8IVH8
QGKVMYRPPPAAPHL

FRAS1

1536

Q86XX4
GGFPDLHGKIQMPVP

EYS

2016

Q5T1H1
MTPQGHRAPPKINPD

INCENP

806

Q9NQS7
GPRTHMQAGPLPKPT

LILRB4

16

Q8NHJ6
PFRQGLTPPQMPGDH

LMX1A

311

Q8TE12
HSPPPLGFQVGMKLE

L3MBTL1

406

Q9Y468
PAPNLPAGKMNHRDP

NRXN2

1556

Q9P2S2
LPNYGPPGHDKMLSP

ONECUT2

246

O95948
AETLKNRMGHQPPPP

NPIPB5

236

A8MRT5
PPKPGLVGHRGAPML

GDPD2

221

Q9HCC8
PKPTIFGHRGAPMLG

GDPD4

196

Q6W3E5
AETLKNRMGHQPPPP

NPIPA3

236

F8WFD2
ETLKNRMGHQPPPPT

NPIPA2

256

E9PIF3
AETLKNRMGHQPPPP

NPIPB4

236

C9JG80
AETLKNRMGHQPPPP

NPIPB11

236

E5RHQ5
PQSLHPGLGGMPKRL

NCOA6

501

Q14686
LGHPPKELAGEMPPG

PEX19

261

P40855
PHKGLGMLPVAPRPA

FZD9

166

O00144
QPAPKGNFPSMPLVG

CEFIP

951

Q711Q0
PGHNPMRPPAFLQQG

BCL9

1311

O00512
PMQKGPVGPPFREGK

COL8A2

46

P25067
MVRGPPPPYHSKPGD

BCL9L

556

Q86UU0
LFTPHPRMPGEQGPK

COL22A1

856

Q8NFW1
TVMAFPPGALHPLPK

MBNL2

266

Q5VZF2
PLNQGPFAPGKPLEM

FAM186A

1766

A6NE01
PGGMKSPPDQPVKHL

HDAC5

666

Q9UQL6
PKAGAPPMPDLLGHR

FAM30A

56

Q9NZY2
GQFPRRVPSMGPPSK

FMN2

616

Q9NZ56
PGIPLKPMLAHPTRG

LIG1

536

P18858
TAPMSGEKHRPPGPL

POM121L1P

311

Q3SYA9
AETLKNRMGHQPPPP

NPIPB13

236

A6NJU9
PPGFPSIDMGPQLKV

PTPRF

131

P10586
AETLKNRMGHQPPPP

NPIPA7

236

E9PJI5
AETLKNRMGHQPPPP

NPIPA8

236

P0DM63
PNPIRKPASMGFPGL

NR4A2

221

P43354
QGRKMGHPPVSPSAP

SYT8

11

Q8NBV8
AETLKNRMGHQPPPP

NPIPA5

236

E9PKD4
EPASQMHVKDPGPPR

PLEKHG4

36

Q58EX7
PGMPHPKGAPAFQLN

PIANP

261

Q8IYJ0
IARDKMPPGPGHLPT

PKD1L3

171

Q7Z443
FGPPMPLHVKQTLSP

INPP5D

921

Q92835
KTPMLPARNPPRFGH

NPAP1

96

Q9NZP6
GMALGHRPIPNQPPT

ACLY

416

P53396
AEMKPLPLHPPGREG

CHST14

66

Q8NCH0
PLPPGKYMAGLNLHP

TNRC18

46

O15417
SLGMPVGPNAHKVPP

SF3B2

616

Q13435
GGSAVPPPPIKHNMN

YTHDF3

261

Q7Z739
LHSPPAPVVKRPGAM

SOX13

266

Q9UN79
FIGPQLPSHMIKNPP

USP42

451

Q9H9J4
ATSPMPGPPLKRKHE

ZFHX2

1821

Q9C0A1
PKPHTGPHIPGMEGE

RALGAPA1

316

Q6GYQ0
PFPKLELGLGPQPMA

RNF112

36

Q9ULX5
AGHIPTGFMPPKVPE

SLC26A2

361

P50443
SLPKPPFGMLFGSQP

ZNF281

731

Q9Y2X9
AETLKNRMGHQPPPP

NPIPB2

251

A6NJ64
VGFDPHPPMRATGLP

TLE3

421

Q04726
MGFPGPGLQSPLHAK

VASN

656

Q6EMK4
PVPPQMGSFKPGGRV

ZMAT3

126

Q9HA38
SPPPGPDGHAKKMRP

WDR4

391

P57081
SKHMQKNPPGPRAPS

ZC3HAV1

221

Q7Z2W4
LPPHLFGPLGPRMSQ

TRIP12

411

Q14669
GDHMKKGPTRPPRPS

WDR7

911

Q9Y4E6
KDFEPQPGNMSHPRP

USP7

1061

Q93009
EPPGLFRGRGNHPKM

TOP1

356

P11387
GSSLPPPPIKHNMDI

YTHDF2

261

Q9Y5A9
SGLMPKHPKEPREPG

ZC3H13

1501

Q5T200
HMIGAQSSPGPKRPG

TRIO

1756

O75962
PGMKHSPSHPVGPKP

TNRC6B

1331

Q9UPQ9
PKPQGLMPPSSHQGL

KMT2D

3771

O14686
ALGPGMPAKPLQHFS

KMT2D

3996

O14686