Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaminoacyltransferase activity

TRIM49 MALT1 TGM2 RNF168 RNF19A RNF19B TRIM49C TRIM49D1 TRIM36 TRIM49B ZNRF2 TRIM51G

2.12e-075326812GO:0016755
GeneOntologyMolecularFunctionacyltransferase activity

ZDHHC2 TRIM49 MALT1 TGM2 RNF168 RNF19A BAZ1A RNF19B TRIM49C TRIM49D1 TRIM36 TRIM49B ZNRF2 TRIM51G

2.75e-077756814GO:0016746
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

TRIM49 MALT1 RNF168 RNF19A RNF19B TRIM49C TRIM49D1 TRIM36 TRIM49B ZNRF2 TRIM51G

5.33e-074736811GO:0004842
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

TRIM49 MALT1 RNF168 RNF19A RNF19B TRIM49C TRIM49D1 TRIM36 TRIM49B ZNRF2 TRIM51G

1.16e-065126811GO:0019787
GeneOntologyMolecularFunctionubiquitin protein ligase activity

TRIM49 RNF168 RNF19A RNF19B TRIM49C TRIM49D1 TRIM49B ZNRF2 TRIM51G

4.59e-06372689GO:0061630
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

TRIM49 RNF168 RNF19A RNF19B TRIM49C TRIM49D1 TRIM49B ZNRF2 TRIM51G

7.91e-06398689GO:0061659
GeneOntologyMolecularFunctionzinc ion binding

TRIM49 RNF19A LMCD1 DTNA RNF19B ZMYND8 TRIM49C TRIM49D1 ADAM30 ZNFX1 TRIM36 TRIM49B TRIM51G

8.18e-068916813GO:0008270
GeneOntologyMolecularFunctiontransition metal ion binding

XYLT2 TRIM49 RNF19A LMCD1 DTNA RNF19B ZMYND8 TRIM49C TRIM49D1 ADAM30 ZNFX1 TRIM36 MUC2 TRIM49B TRIM51G

8.61e-0611896815GO:0046914
GeneOntologyMolecularFunctionhistone modifying activity

TGM2 RNF168 BAZ1A PRMT7 HR

1.10e-03229685GO:0140993
GeneOntologyMolecularFunctionintramolecular oxidoreductase activity, transposing S-S bonds

PDIA4 P4HB

2.53e-0322682GO:0016864
GeneOntologyMolecularFunctionprotein disulfide isomerase activity

PDIA4 P4HB

2.53e-0322682GO:0003756
GeneOntologyMolecularFunctionD-mannose binding

CLEC4M CLEC10A

3.80e-0327682GO:0005537
GeneOntologyBiologicalProcesspositive regulation of receptor clustering

ZDHHC2 LRP4 TNFAIP6

3.06e-0519673GO:1903911
MousePhenoabnormal long-term potentiation

NELL2 NETO1 RNF19A LAMA2 PLAT NBEA SIPA1L2

2.11e-05221547MP:0002207
DomainConA-like_dom

TRIM49 NELL2 CNTNAP1 TRIM49C LAMA2 TRIM49D1 NBEA TRIM36 TRIM49B

7.37e-08219669IPR013320
DomainRING

TRIM49 RNF168 RNF19A BAZ1A RNF19B TRIM49C TRIM49D1 TRIM36 TRIM49B ZNRF2

1.09e-073056610SM00184
DomainZnf_RING

TRIM49 RNF168 RNF19A BAZ1A RNF19B TRIM49C TRIM49D1 TRIM36 TRIM49B ZNRF2

2.03e-073266610IPR001841
DomainEGF-like_dom

NELL2 ADAM21 CNTNAP1 LAMA2 LRP4 ADAM30 LAMC3 PLAT C8A

2.20e-07249669IPR000742
DomainEGF_1

NELL2 ADAM21 CNTNAP1 LAMA2 LRP4 ADAM30 LAMC3 PLAT C8A

2.69e-07255669PS00022
DomainEGF-like_CS

NELL2 ADAM21 CNTNAP1 LAMA2 LRP4 ADAM30 LAMC3 PLAT C8A

3.27e-07261669IPR013032
DomainEGF_2

NELL2 ADAM21 CNTNAP1 LAMA2 LRP4 ADAM30 LAMC3 PLAT C8A

3.72e-07265669PS01186
Domain-

TRIM49 RNF168 RNF19A BAZ1A RNF19B ZMYND8 TRIM49C TRIM49D1 TRIM36 TRIM49B ZNRF2

4.48e-0744966113.30.40.10
DomainZnf_RING/FYVE/PHD

TRIM49 RNF168 RNF19A BAZ1A RNF19B ZMYND8 TRIM49C TRIM49D1 TRIM36 TRIM49B ZNRF2

5.57e-074596611IPR013083
DomainZF_RING_2

TRIM49 RNF168 RNF19A RNF19B TRIM49C TRIM49D1 TRIM36 TRIM49B ZNRF2

9.91e-07298669PS50089
DomainBBOX

TRIM49 TRIM49C TRIM49D1 TRIM36 TRIM49B

4.46e-0669665SM00336
DomainButyrophylin

TRIM49 TRIM49C TRIM49D1 TRIM36 TRIM49B

4.79e-0670665IPR003879
Domain-

TRIM49 TRIM49C TRIM49D1 TRIM36 TRIM49B

5.14e-06716654.10.45.10
Domainzf-B_box

TRIM49 TRIM49C TRIM49D1 TRIM36 TRIM49B

5.50e-0672665PF00643
DomainZF_RING_1

TRIM49 RNF168 RNF19A RNF19B TRIM49C TRIM36 TRIM49B ZNRF2

8.28e-06291668PS00518
DomainZF_BBOX

TRIM49 TRIM49C TRIM49D1 TRIM36 TRIM49B

9.25e-0680665PS50119
DomainZnf_B-box

TRIM49 TRIM49C TRIM49D1 TRIM36 TRIM49B

9.84e-0681665IPR000315
DomainLDLR_class-A_CS

LRP12 NETO1 LRP4 C8A

1.18e-0540664IPR023415
DomainEGF_3

NELL2 ADAM21 CNTNAP1 LRP4 ADAM30 PLAT C8A

1.89e-05235667PS50026
DomainLdl_recept_a

LRP12 NETO1 LRP4 C8A

1.90e-0545664PF00057
DomainSPRY

TRIM49 TRIM49C TRIM49D1 TRIM36 TRIM49B

2.03e-0594665PF00622
DomainSPRY_dom

TRIM49 TRIM49C TRIM49D1 TRIM36 TRIM49B

2.03e-0594665IPR003877
Domain-

LRP12 NETO1 LRP4 C8A

2.08e-05466644.10.400.10
DomainB30.2/SPRY

TRIM49 TRIM49C TRIM49D1 TRIM36 TRIM49B

2.14e-0595665IPR001870
DomainB302_SPRY

TRIM49 TRIM49C TRIM49D1 TRIM36 TRIM49B

2.14e-0595665PS50188
DomainLDLRA_1

LRP12 NETO1 LRP4 C8A

2.46e-0548664PS01209
DomainLDLRA_2

LRP12 NETO1 LRP4 C8A

2.67e-0549664PS50068
DomainLDrepeatLR_classA_rpt

LRP12 NETO1 LRP4 C8A

2.67e-0549664IPR002172
DomainLDLa

LRP12 NETO1 LRP4 C8A

2.67e-0549664SM00192
DomainProt_disulphide_isomerase

PDIA4 P4HB

7.35e-054662IPR005792
DomainEGF

NELL2 CNTNAP1 LAMA2 LRP4 LAMC3 PLAT

1.80e-04235666SM00181
DomainSPRY

TRIM49 TRIM49C TRIM49D1 TRIM49B

2.54e-0487664SM00449
DomainLAMININ_IVA

LAMA2 LAMC3

3.40e-048662PS51115
DomainLaminin_B

LAMA2 LAMC3

3.40e-048662PF00052
DomainDisulphide_isomerase

PDIA4 P4HB

3.40e-048662IPR005788
DomainLamB

LAMA2 LAMC3

3.40e-048662SM00281
DomainLaminin_IV

LAMA2 LAMC3

3.40e-048662IPR000034
Domain-

NELL2 CNTNAP1 LAMA2 NBEA

3.56e-04956642.60.120.200
DomainLaminin_G_2

NELL2 CNTNAP1 LAMA2

3.79e-0440663PF02210
Domain-

MRC2 TNFAIP6 CLEC4M CLEC10A

3.85e-04976643.10.100.10
DomainC-type_lectin-like/link

MRC2 TNFAIP6 CLEC4M CLEC10A

4.16e-0499664IPR016186
DomainBTK

RASA2 TEC

4.36e-049662SM00107
DomainZnf_Btk_motif

RASA2 TEC

4.36e-049662IPR001562
DomainBTK

RASA2 TEC

4.36e-049662PF00779
DomainZF_BTK

RASA2 TEC

4.36e-049662PS51113
DomainC-type_lectin_CS

MRC2 CLEC4M CLEC10A

4.70e-0443663IPR018378
DomainLamG

NELL2 CNTNAP1 LAMA2

5.03e-0444663SM00282
DomainE3_UB_ligase_RBR

RNF19A RNF19B

5.43e-0410662IPR031127
DomainCTDL_fold

MRC2 TNFAIP6 CLEC4M CLEC10A

5.59e-04107664IPR016187
DomainCUB

LRP12 NETO1 TNFAIP6

6.91e-0449663PF00431
DomainCUB

LRP12 NETO1 TNFAIP6

7.34e-0450663SM00042
Domain-

LRP12 NETO1 TNFAIP6

8.23e-04526632.60.120.290
DomainCUB

LRP12 NETO1 TNFAIP6

8.70e-0453663PS01180
DomainThioredoxin

PDIA4 P4HB

9.36e-0413662IPR005746
DomainCUB_dom

LRP12 NETO1 TNFAIP6

1.08e-0357663IPR000859
DomainIBR

RNF19A RNF19B

1.09e-0314662SM00647
DomainIBR

RNF19A RNF19B

1.09e-0314662PF01485
DomainLaminin_G

NELL2 CNTNAP1 LAMA2

1.13e-0358663IPR001791
DomainIBR_dom

RNF19A RNF19B

1.25e-0315662IPR002867
DomainLaminin_N

LAMA2 LAMC3

1.43e-0316662IPR008211
DomainDisintegrin_CS

ADAM21 ADAM30

1.43e-0316662IPR018358
DomainLAMININ_NTER

LAMA2 LAMC3

1.43e-0316662PS51117
DomainLaminin_N

LAMA2 LAMC3

1.43e-0316662PF00055
DomainLamNT

LAMA2 LAMC3

1.43e-0316662SM00136
DomainThioredoxin_CS

PDIA4 P4HB

1.62e-0317662IPR017937
DomainADAM_CR

ADAM21 ADAM30

1.81e-0318662PF08516
DomainLIM

LMCD1 FHL1 FHL2

1.87e-0369663PF00412
Domain-

LMCD1 FHL1 FHL2

1.95e-03706632.10.110.10
DomainVWC_out

NELL2 MUC2

2.02e-0319662SM00215
DomainZnf_LIM

LMCD1 FHL1 FHL2

2.03e-0371663IPR001781
DomainLIM_DOMAIN_1

LMCD1 FHL1 FHL2

2.03e-0371663PS00478
DomainLIM_DOMAIN_2

LMCD1 FHL1 FHL2

2.03e-0371663PS50023
DomainLIM

LMCD1 FHL1 FHL2

2.03e-0371663SM00132
Domain-

CNTNAP1 LAMA2 LAMC3

2.20e-03736632.60.120.260
Domain-

ADAM21 ADAM30

2.24e-03206624.10.70.10
DomainGrowth_fac_rcpt_

NELL2 LRP4 LAMC3 C8A

2.26e-03156664IPR009030
DomainDisintegrin

ADAM21 ADAM30

2.47e-0321662PF00200
Domainzf-MYND

ZMYND8 USP19

2.47e-0321662PF01753
DomainTetraspanin_CS

CD37 TSPAN8

2.47e-0321662IPR018503
DomainDISIN

ADAM21 ADAM30

2.47e-0321662SM00050
DomainZnf_MYND

ZMYND8 USP19

2.71e-0322662IPR002893
DomainZF_MYND_1

ZMYND8 USP19

2.71e-0322662PS01360
DomainZF_MYND_2

ZMYND8 USP19

2.71e-0322662PS50865
DomainC_TYPE_LECTIN_1

MRC2 CLEC4M CLEC10A

2.85e-0380663PS00615
DomainLectin_C

MRC2 CLEC4M CLEC10A

3.27e-0384663PF00059
DomainCLECT

MRC2 CLEC4M CLEC10A

3.27e-0384663SM00034
DomainC_TYPE_LECTIN_2

MRC2 CLEC4M CLEC10A

3.39e-0385663PS50041
DomainC-type_lectin-like

MRC2 CLEC4M CLEC10A

3.50e-0386663IPR001304
DomainTHIOREDOXIN_1

PDIA4 P4HB

3.50e-0325662PS00194
Pubmed

Identification of a genomic reservoir for new TRIM genes in primate genomes.

TRIM49 TRIM49C TRIM49D1 TRIM49B TRIM51G

3.02e-101969522144910
Pubmed

Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway.

FHL1 FHL2 SMAD2

4.16e-07869319139564
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

PDIA4 XYLT2 TGM2 LRP12 NELL2 TMEM201 P4HB MRC2 CNTNAP1 LRP4 LAMC3 USP19 SMAD2

5.97e-071201691335696571
Pubmed

Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos.

TRIM49 TRIM49C TRIM49B

3.34e-061569319703589
Pubmed

Muc2-dependent microbial colonization of the jejunal mucus layer is diet sensitive and confers local resistance to enteric pathogen infection.

TGM2 MUC2

3.88e-06269236753416
Pubmed

ERp72, an abundant luminal endoplasmic reticulum protein, contains three copies of the active site sequences of protein disulfide isomerase.

PDIA4 P4HB

3.88e-0626922295602
Pubmed

Four-and-a-half LIM domains proteins are novel regulators of the protein kinase D pathway in cardiac myocytes.

FHL1 FHL2

3.88e-06269224219103
Pubmed

Characterization and expression of the laminin gamma3 chain: a novel, non-basement membrane-associated, laminin chain.

LAMA2 LAMC3

1.16e-05369210225960
Pubmed

The LIM proteins FHL1 and FHL3 are expressed differently in skeletal muscle.

FHL1 FHL2

1.16e-05369210049693
Pubmed

Expression patterns of FHL/SLIM family members suggest important functional roles in skeletal muscle and cardiovascular system.

FHL1 FHL2

1.16e-05369210906474
Pubmed

Elevated expression of PDI family proteins during differentiation of mouse F9 teratocarcinoma cells.

PDIA4 P4HB

1.16e-0536929493907
Pubmed

Slim defines a novel family of LIM-proteins expressed in skeletal muscle.

FHL1 FHL2

1.16e-0536928753811
Pubmed

Human chromosome 11 DNA sequence and analysis including novel gene identification.

TRIM49 TRIM49C TRIM49D1 LRP4

2.00e-058069416554811
Pubmed

DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist.

CLEC4M CLEC10A

2.32e-05469234015061
Pubmed

Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly.

FHL1 FHL2

2.32e-05469216407297
Pubmed

Tumor suppressor microRNA-27a in colorectal carcinogenesis and progression by targeting SGPP1 and Smad2.

MUC2 SMAD2

2.32e-05469225166914
Pubmed

Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.

RNF19A RNF19B TRIM36 ZNRF2

2.54e-058569419028597
Pubmed

SARS-CoV-2 Spike Protein Interacts with Multiple Innate Immune Receptors.

CLEC4M CLEC10A

3.86e-05569232766577
Pubmed

Properly formed but improperly localized synaptic specializations in the absence of laminin alpha4.

DTNA LAMA2

3.86e-05569211369940
Pubmed

FHL family members suppress vascular endothelial growth factor expression through blockade of dimerization of HIF1α and HIF1β.

FHL1 FHL2

3.86e-05569223086815
Pubmed

Four-and-a-half LIM domain proteins inhibit transactivation by hypoxia-inducible factor 1.

FHL1 FHL2

5.79e-05669222219185
Pubmed

Disulphide production by Ero1α-PDI relay is rapid and effectively regulated.

PDIA4 P4HB

5.79e-05669220802462
Pubmed

pH dependence of the peptide thiol-disulfide oxidase activity of six members of the human protein disulfide isomerase family.

PDIA4 P4HB

5.79e-05669216677074
Pubmed

Glycosaminoglycans and protein disulfide isomerase-mediated reduction of HIV Env.

PDIA4 P4HB

5.79e-05669215644496
Pubmed

A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM.

FHL1 FHL2

5.79e-05669211046156
Pubmed

Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2.

FHL1 FHL2

5.79e-05669212432079
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

P4HB DTNA AGL LAMA2 ZNF619 FHL1 SMAD2

5.86e-0549769723414517
Pubmed

Snapshot of the interaction between HIV envelope glycoprotein 120 and protein disulfide isomerase.

PDIA4 P4HB

8.09e-05769220458450
Pubmed

Inhibitors of protein-disulfide isomerase prevent cleavage of disulfide bonds in receptor-bound glycoprotein 120 and prevent HIV-1 entry.

PDIA4 P4HB

8.09e-05769212218051
Pubmed

SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2.

CLEC4M CLEC10A

8.09e-05769234048708
Pubmed

Stability of a receptor-binding active human immunodeficiency virus type 1 recombinant gp140 trimer conferred by intermonomer disulfide bonding of the V3 loop: differential effects of protein disulfide isomerase on CD4 and coreceptor binding.

PDIA4 P4HB

8.09e-05769217301129
Pubmed

Cell-type specific requirements for thiol/disulfide exchange during HIV-1 entry and infection.

PDIA4 P4HB

8.09e-05769223206338
Pubmed

Cytoplasmic gamma-actin expression in diverse animal models of muscular dystrophy.

DTNA LAMA2

8.09e-05769217475492
Pubmed

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.

MALT1 BAZ1A P4HB AGL ZMYND8 ZKSCAN8 LAMC3 ZNF236 USP19

8.70e-0592569928986522
Pubmed

Protein-disulfide isomerase-mediated reduction of two disulfide bonds of HIV envelope glycoprotein 120 occurs post-CXCR4 binding and is required for fusion.

PDIA4 P4HB

1.08e-04869212218052
Pubmed

Proteins of the PDI family: unpredicted non-ER locations and functions.

PDIA4 P4HB

1.08e-04869212384992
Pubmed

Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites.

CLEC4M CLEC10A

1.08e-04869234375000
Pubmed

An improved smaller biotin ligase for BioID proximity labeling.

FSIP2 LRP12 NETO1 ZMYND8

1.08e-0412369426912792
Pubmed

Mapping Extracellular Protein-Protein Interactions Using Extracellular Proximity Labeling (ePL).

TGM2 MRC2 PLAT TNFAIP6 FHL2

1.35e-0424769539238192
Pubmed

RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication.

MMS19 MCM10

1.73e-041069224115439
Pubmed

Trophoblast-specific expression and function of the integrin alpha 7 subunit in the peri-implantation mouse embryo.

LAMA2 LAMC3

1.73e-041069211784026
Pubmed

Lineage-specific biology revealed by a finished genome assembly of the mouse.

TRIM49 TRIM49C TRIM49B

1.82e-045569319468303
Pubmed

Regional differences in the expression of laminin isoforms during mouse neural tube development.

LAMA2 LAMC3

2.11e-041169221524702
Pubmed

Mutations in LAMB1 cause cobblestone brain malformation without muscular or ocular abnormalities.

LAMA2 LAMC3

2.11e-041169223472759
Pubmed

Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure.

ZMYND8 NBEA SMAD2

2.13e-045869337973188
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

NELL2 NETO1 CNTNAP1 ZMYND8 LRP4 NBEA ZNFX1 ZNF619 FHL1 SMAD2

2.14e-041285691035914814
Pubmed

Wnt5a Deficiency Leads to Anomalies in Ureteric Tree Development, Tubular Epithelial Cell Organization and Basement Membrane Integrity Pointing to a Role in Kidney Collecting Duct Patterning.

LAMA2 LAMC3

2.53e-041269226794322
Pubmed

Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions.

CD37 TSPAN8

2.53e-041269210229664
Pubmed

Mapping of three members of the mouse protein disulfide isomerase family.

PDIA4 P4HB

2.53e-04126929457688
Pubmed

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.

TGM2 P4HB MRC2 FHL1 FHL2

2.61e-0428569521423176
Pubmed

A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins.

PDIA4 P4HB

3.48e-041469212475965
Pubmed

The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF.

FHL1 FHL2

3.48e-041469215610731
Pubmed

Basement membrane composition in the early mouse embryo day 7.

LAMA2 LAMC3

4.01e-041569215895400
Pubmed

A point mutation in the Pdia6 gene results in loss of pancreatic β-cell identity causing overt diabetes.

PDIA4 P4HB

4.01e-041569234487921
Pubmed

Rasal2 deficiency reduces adipogenesis and occurrence of obesity-related disorders.

MRC2 CLEC10A

4.01e-041569228580280
Pubmed

A signature motif in LIM proteins mediates binding to checkpoint proteins and increases tumour radiosensitivity.

FHL1 FHL2

4.01e-041569228094252
Pubmed

Laminin alpha5 is necessary for submandibular gland epithelial morphogenesis and influences FGFR expression through beta1 integrin signaling.

LAMA2 LAMC3

4.57e-041669217601529
Pubmed

Tagging genes with cassette-exchange sites.

MALT1 MAP4K3 ZMYND8 MMS19 MCM10

5.46e-0433569515741177
Pubmed

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.

ZDHHC2 LRP12 P4HB MAP4K3 LRP4 MMS19 SYT13

5.57e-0471969735337019
Pubmed

Chromosomal mapping of Adam9, Adam15 and Adam21.

ADAM21 PLAT

5.81e-041869210842103
Pubmed

Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53.

LAMA2 LAMC3

5.81e-041869211311202
Pubmed

Genetic analysis of anterior posterior expression gradients in the developing mammalian forebrain.

FHL1 FHL2

5.81e-041869217150988
Pubmed

Misregulation of an Activity-Dependent Splicing Network as a Common Mechanism Underlying Autism Spectrum Disorders.

ZMYND8 NBEA

5.81e-041869227984743
Pubmed

Animal Models of Congenital Cardiomyopathies Associated With Mutations in Z-Line Proteins.

FHL1 FHL2

6.49e-041969227171814
Pubmed

PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.

TSPAN8 ADAM30

7.20e-042069219862325
Pubmed

Laminin and integrin expression in the ventral ectodermal ridge of the mouse embryo: implications for regulation of BMP signalling.

LAMA2 LAMC3

7.20e-042069222911573
Pubmed

Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium.

MCM10 MUC2

7.20e-042069226023099
Pubmed

Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.

TSPAN8 ADAM30

7.95e-042169218591388
Pubmed

Schwann cell myelination requires integration of laminin activities.

LAMA2 LAMC3

7.95e-042169222767514
Pubmed

Putative complement control protein CSMD3 dysfunction impairs synaptogenesis and induces neurodevelopmental disorders.

LAMA2 LAMC3

8.73e-042269235245678
Pubmed

Mapping wild-type and R345W fibulin-3 intracellular interactomes.

PDIA4 P4HB

8.73e-042269227777122
Pubmed

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.

TSPAN8 ADAM30

8.73e-042269218372903
Pubmed

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

RNF168 RNF19A RNF19B

9.08e-049569329643511
Pubmed

Complexes of tetraspanins with integrins: more than meets the eye.

CD37 TSPAN8

1.04e-032469211739647
Pubmed

Conditional deletion of beta1-integrin in astroglia causes partial reactive gliosis.

DTNA LAMA2

1.13e-032569219373938
Pubmed

Functional proteomics mapping of a human signaling pathway.

TGM2 RNF168 BAZ1A ZMYND8 FHL2 SMAD2

1.14e-0359169615231748
Pubmed

Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins.

LAMA2 LAMC3

1.22e-032669224742657
Pubmed

Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2.

FHL1 FHL2

1.32e-032769236899856
Pubmed

Expanding the substantial interactome of NEMO using protein microarrays.

LMCD1 MCM10 TEC

1.35e-0310969320098747
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

TGM2 TMEM201 RASA2 BAZ1A P4HB MAP4K3 MMS19 MCM10 FHL2

1.38e-03135369929467282
Pubmed

Tumor-derived neomorphic mutations in ASXL1 impairs the BAP1-ASXL1-FOXK1/K2 transcription network.

TGM2 P4HB MMS19

1.42e-0311169332683582
Pubmed

JMJD1C Exhibits Multiple Functions in Epigenetic Regulation during Spermatogenesis.

RNF168 BAZ1A

1.52e-032969227649575
Pubmed

Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.

PDIA4 P4HB

1.52e-032969212643545
Pubmed

Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.

ZMYND8 NBEA

1.74e-033169225838543
Pubmed

∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.

PDIA4 TGM2 P4HB MMS19 FHL1 FHL2

1.80e-0364769626618866
Pubmed

Discrete gene sets depend on POU domain transcription factor Brn3b/Brn-3.2/POU4f2 for their expression in the mouse embryonic retina.

NELL2 SYT13

1.85e-033269214973295
Pubmed

A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins.

CLEC4M CLEC10A

1.97e-033369223118208
Cytoband11q14.3

RHOD TRIM49C TRIM49D1

1.56e-053269311q14.3
CytobandEnsembl 112 genes in cytogenetic band chr11p11

LRP4 TRIM49B SYT13 TRIM51G

8.66e-05153694chr11p11
CytobandEnsembl 112 genes in cytogenetic band chr11q14

TRIM49 TRIM49C TRIM49D1

1.71e-03156693chr11q14
Cytoband11p11.12

TRIM49B TRIM51G

1.84e-034269211p11.12
GeneFamilyRing finger proteins

TRIM49 RNF168 RNF19A RNF19B TRIM49C TRIM49D1 TRIM36 TRIM49B ZNRF2

1.32e-0727555958
GeneFamilyRing finger proteins|Tripartite motif containing|ARF GTPase family

TRIM49 TRIM49C TRIM49D1 TRIM36 TRIM49B TRIM51G

4.23e-079555659
GeneFamilyC-type lectin domain family

MRC2 CLEC4M CLEC10A

3.93e-0447553494
GeneFamilyLaminin subunits

LAMA2 LAMC3

5.88e-0412552626
GeneFamilyLow density lipoprotein receptors

LRP12 LRP4

6.94e-0413552634
GeneFamilyLIM domain containing

LMCD1 FHL1 FHL2

7.68e-04595531218
GeneFamilyProtein disulfide isomerases

PDIA4 P4HB

1.84e-0321552692
GeneFamilyZinc fingers MYND-type

ZMYND8 USP19

1.84e-032155287
GeneFamilyADAM metallopeptidase domain containing|CD molecules

ADAM21 ADAM30

3.04e-032755247
GeneFamilyCD molecules|Tetraspanins

CD37 TSPAN8

4.52e-0333552768
CoexpressionMURARO_PANCREAS_MESENCHYMAL_STROMAL_CELL

TGM2 RNF168 BAZ1A LMCD1 MRC2 LAMA2 LAMC3 PLAT TNFAIP6 FHL2

7.46e-066816610M39175
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMEM201 RNF19A LRP4 LAMC3 PLAT CLEC10A

1.83e-071606966215ac6123a295f3c2f033786602a57b2e2e1177
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NETO1 MRC2 LAMA2 LAMC3 TNFAIP6 FHL2

5.52e-07193696dc8e62df6121ee99b156aca6b1b3ae555739b6f2
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NETO1 MRC2 LAMA2 LAMC3 TNFAIP6 FHL2

5.52e-07193696e2ee077fd381bd906e6b4329f22e7d106e422a7f
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TGM2 MAP4K3 LMCD1 PLAT FHL1 FHL2

6.41e-0719869609be07ebfc3e49c3858e9b74605b69cf4fc28b56
ToppCellASK452-Mesenchymal-Fibroblast|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

LMCD1 TSPAN8 LAMA2 LAMC3 TNFAIP6 FHL1

6.60e-071996964d0bf2a4bd97e5a3bfe4570a201cc21bb9c4c1f6
ToppCellASK452-Mesenchymal|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

LMCD1 TSPAN8 LAMA2 LAMC3 TNFAIP6 FHL1

6.60e-0719969693e85e3731a9ece9aee3eb82c5dfdad331ee62d6
ToppCellTransplant_Alveoli_and_parenchyma-Mesenchymal-Fibroblasts|Mesenchymal / Tissue, Lineage and Cell class of Lung Cells from 10X

P4HB MRC2 TSPAN8 LAMA2 PLAT TNFAIP6

6.60e-07199696f19c683f38bca3bfee40396f27423441051dec67
ToppCellmedial-2-mesenchymal|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LMCD1 MRC2 TSPAN8 LAMA2 LAMC3 FHL2

6.80e-07200696a9d8aa5bcf383d98a9e2eaf4b1f8466982d6b088
ToppCellLPS_only-Mesenchymal_myocytic-Pericyte-Pericyte_2|LPS_only / Treatment groups by lineage, cell group, cell type

LMCD1 MRC2 LAMA2 LAMC3 PLAT NBEA

6.80e-0720069669edc375d85689300d1dbc1217fedc40063ecdcb
ToppCellmedial-mesenchymal|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LMCD1 MRC2 TSPAN8 LAMA2 LAMC3 FHL2

6.80e-072006964f19e1e40966e27779bf77e8c170ed3ecc24353e
ToppCellControl_saline-Mesenchymal_myocytic-Pericyte-Pericyte_2|Control_saline / Treatment groups by lineage, cell group, cell type

MAP4K3 MRC2 LAMA2 LAMC3 PLAT TNFAIP6

6.80e-07200696bc8949eb34482aca166c4602ff6ab876cb4c2c3c
ToppCellSubstantia_nigra-Endothelial-ENDOTHELIAL_TIP|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

MRC2 LAMA2 LAMC3 FHL2 TEC

4.85e-06159695cb2470b288c13e454a2a80115b0d5613b3f718e6
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Microglia/Mac|Myeloid_cells / Location, Cell class and cell subclass

ANKRD44 TMEM201 ZKSCAN8 ZNF619 ZNRF2

6.52e-06169695dba8f5599aa21feef5b7fdfed2e3ab54748d80f7
ToppCellfacs-Marrow-B-cells-24m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NETO1 CD37 PTPRQ LAMA2 SYT13

7.72e-06175695887e75fc90e59a6394d62f3c048a9cfdf6707725
ToppCellCOVID-19-Heart-CM_3|COVID-19 / Disease (COVID-19 only), tissue and cell type

LMCD1 DTNA LAMA2 FHL1 FHL2

7.94e-061766959df7a124ebafb0087da0cda133a394275d7bed81
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP12 BAZ1A RNF19B PTPRQ ZNRF2

7.94e-06176695b0b87eebcf5c994386b39ca607e17f10e9d9de74
ToppCellfacs-Liver-Non-hepatocytes-24m-Endothelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DENND2C LAMA2 LAMC3 PLAT FHL1

9.59e-06183695ebe369dc80c4fbf8f4dbe947147f8c47507ffb60
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC2 LAMA2 PLAT TNFAIP6 FHL1

1.12e-05189695bc54ffd7bd1627a36747a80ce5139e4a69928400
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal-stromal_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC2 LAMA2 PLAT TNFAIP6 FHL1

1.15e-05190695f3ca94a31a35eed5fecf3c4b8c957e1bc4150158
ToppCelldroplet-Mammary_Gland-nan-21m-Mesenchymal|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC2 LAMA2 PLAT TNFAIP6 FHL1

1.15e-05190695c2cd1eb674162ee40502c3380b7245c85079c7ce
ToppCelldroplet-Lung-21m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DTNA MRC2 LAMA2 LRP4 FHL1

1.18e-05191695c715bbdbbf1482aad45a50a16d5232fd35a9a0bb
ToppCelldroplet-Lung-21m-Mesenchymal-fibroblast-alveolar_fibroblast|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DTNA MRC2 LAMA2 LRP4 FHL1

1.18e-05191695243d83cbfcc4996ad087ec6386e559e0b8662004
ToppCellIPF-Epithelial-Goblet|Epithelial / Disease state, Lineage and Cell class

TGM2 LMCD1 TSPAN8 SIPA1L2 FHL2

1.18e-05191695267e1192aaec468c1a59eb24848b37e0e18cbc44
ToppCellHippocampus-Endothelial|Hippocampus / BrainAtlas - Mouse McCarroll V32

TGM2 RHOD MRC2 LAMC3 TEC

1.21e-0519269536deadab892d3e639a71f33697bb2d3cbbaa5372
ToppCellCOVID-19-Fibroblasts-Alveolar_FB|COVID-19 / group, cell type (main and fine annotations)

TGM2 LMCD1 DTNA LAMA2 FHL1

1.30e-05195695603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCellfacs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MRC2 LAMA2 PLAT TNFAIP6 FHL1

1.34e-05196695d4676a6b0d9e417795fc9a6bcb1762d3dd656ca9
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LMCD1 MRC2 LAMA2 LAMC3 FHL1

1.37e-0519769585a8f1d18e0dd1d31341f5131eecd217553bf042
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LMCD1 MRC2 LAMA2 LAMC3 FHL1

1.37e-05197695e8e3ba791dfaa0fab35e0329a5e34376f9ee6143
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NETO1 MRC2 LAMA2 LAMC3 FHL2

1.37e-051976954cf4e9553397cd8dee883dbec24f41bec41aff99
ToppCell367C-Fibroblasts-Fibroblast-C_(Myofibroblast)|367C / Donor, Lineage, Cell class and subclass (all cells)

TGM2 MRC2 TSPAN8 LAMA2 FHL1

1.40e-05198695a9afedbc0556faf4a46f7bf28f4a9adb3bc859d8
ToppCellfacs-Trachea-nan-3m-Mesenchymal-fibroblast|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MRC2 LAMA2 PLAT TNFAIP6 FHL1

1.40e-051986950dc7d59a07428a7b7e8bdc81f0e2417dd4ce3cf2
ToppCellCOVID-19-kidney-Fibroblast-2|kidney / Disease (COVID-19 only), tissue and cell type

LMCD1 MRC2 LAMA2 LAMC3 FHL2

1.40e-05198695ca26ca460856b1faaa3e83766da6abdf63af2b51
ToppCell367C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|367C / Donor, Lineage, Cell class and subclass (all cells)

TGM2 MRC2 TSPAN8 LAMA2 FHL1

1.40e-051986957b5350768f306ec528e271d2ac4470bf668ec6f0
ToppCelldistal-mesenchymal-Alveolar_Fibroblast-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LMCD1 MRC2 TSPAN8 LAMA2 FHL1

1.44e-0519969528c1722deef3b8347371c7359be7c64b95780de3
ToppCell3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PDIA4 P4HB LMCD1 TNFAIP6 FHL1

1.44e-05199695a457964ed95ce8cfc9d276508efbf79a2d195fe4
ToppCell343B-Fibroblasts-Fibroblast-G|343B / Donor, Lineage, Cell class and subclass (all cells)

TGM2 LMCD1 TSPAN8 LAMA2 FHL1

1.44e-05199695f4b6c095cbe7a38b310adc49be4069e4d56e6a66
ToppCell343B-Fibroblasts-Fibroblast-G-|343B / Donor, Lineage, Cell class and subclass (all cells)

TGM2 LMCD1 TSPAN8 LAMA2 FHL1

1.44e-051996959c6d1c328bfbb6547f4c7bb2a784576a56bd72af
ToppCellCOVID-19-kidney-Fibroblast-1|kidney / Disease (COVID-19 only), tissue and cell type

LMCD1 MRC2 LAMA2 LAMC3 FHL2

1.44e-051996959503646ff1ad248181146ce767e9d12e882ec3bd
ToppCellLPS_only-Mesenchymal_fibroblastic-Fibroblasts-Diff_MatrixFB|LPS_only / Treatment groups by lineage, cell group, cell type

TGM2 P4HB MRC2 FHL1 FHL2

1.47e-05200695ab4fda0cc95cb8f80ea9f28745013f3248def820
ToppCell343B-Fibroblasts|343B / Donor, Lineage, Cell class and subclass (all cells)

TGM2 LMCD1 TSPAN8 LAMA2 FHL1

1.47e-05200695376c1a77031e090be96948b47c78ac0d393f5775
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TGM2 LMCD1 DTNA LAMA2 FHL1

1.47e-05200695e8462395fee0a532d1e7ec7f1795f28c42af6541
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Pericyte-Pericyte_2|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

LMCD1 LAMA2 LAMC3 PLAT NBEA

1.47e-05200695d2fcd3bd7c3223875f027eeb48ff621192a5f242
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Pericyte-Pericyte_2|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

LMCD1 MRC2 LAMA2 LAMC3 PLAT

1.47e-05200695cf883ba5dbe6350b93142d625a52b25ff2a8bb63
ToppCellLung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-4-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

LMCD1 MRC2 LAMA2 TNFAIP6 FHL2

1.47e-052006954dbe21cb63569f28c7017cda065ea5ee00d7254e
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial-Proteoglycan-expressing_cell|GW19 / Sample Type, Dataset, Time_group, and Cell type.

FSIP2 CD37 DNAH2 LAMC3 TNFAIP6

1.47e-05200695aafe594c88710f8c53d59667cdac5035e08f5511
ToppCellParenchymal-10x5prime-Stromal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LMCD1 MRC2 LAMA2 LAMC3 TNFAIP6

1.47e-052006952e525c0d9684e7a2275edb04e1addb6fc6a872e5
ToppCellParenchyma_COVID-19-Stromal-TX-Fibroblasts-4|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

LMCD1 MRC2 LAMA2 TNFAIP6 FHL2

1.47e-05200695bde938e5a18844fb8cc1d1be5a086809f7e2b97d
ToppCellLung_Parenchyma-Severe-Mesenchymal-Mesenchymal-Fibroblasts-4|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

LMCD1 MRC2 LAMA2 TNFAIP6 FHL2

1.47e-052006958256511b099c3eab8e33194f90c9ff354e7cfe8e
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Pericyte-Pericyte_2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

LMCD1 MRC2 LAMA2 LAMC3 PLAT

1.47e-05200695786f1ae53e60b5ffbf4bfd393d10b802478148b3
ToppCellLPS_only-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_only / Treatment groups by lineage, cell group, cell type

LMCD1 LAMA2 LRP4 NBEA FHL2

1.47e-05200695a9ff3210127000b3dd9e97136163c98c2b0817d7
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial|GW19 / Sample Type, Dataset, Time_group, and Cell type.

FSIP2 CD37 DNAH2 LAMC3 TNFAIP6

1.47e-05200695a6f0f5f644b7262878b0b9d4d90ee407c4124dd9
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TGM2 LMCD1 DTNA LAMA2 FHL1

1.47e-0520069534f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCelldistal-3-mesenchymal-Alveolar_Fibroblast|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

LMCD1 MRC2 TSPAN8 PLAT FHL1

1.47e-0520069520112be28f80baffad92641c9cfd7c3718967dbb
ToppCellBronchial_Biopsy-Mesenchymal-Fibroblasts|Mesenchymal / Tissue, Lineage and Cell class of Lung Cells from 10X

TGM2 P4HB LAMA2 FHL1

4.83e-0512969413cd10ffdd8f1ef7721884e9efd2cf25f170f414
ToppCellfrontal_cortex-Non-neuronal-macrophage-Macrophage-PVM_Mrc1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

FOLR2 DENND2C TSPAN8 CLEC10A

8.23e-05148694d3ea907f8f408e9bb97ed223a3089e403e35f911
ToppCellE16.5-samps-Myeloid-Macrophage|E16.5-samps / Age Group, Lineage, Cell class and subclass

CD37 DNAH2 ZNRF2 TEC

8.23e-05148694cd5f697d8c2f272be1f3f52a05446749278431c5
ToppCellE16.5-samps-Myeloid-Macrophage-CD163+_Macrophage|E16.5-samps / Age Group, Lineage, Cell class and subclass

CD37 DNAH2 ZNRF2 TEC

8.23e-0514869456e146980a71b5ca655118ae13310c5949220d4a
ToppCell3'_v3-bone_marrow-Lymphocytic_Invariant-Inducer-like-ILC3|bone_marrow / Manually curated celltypes from each tissue

TGM2 MRC2 TEC FHL1

8.45e-05149694d7f1069f70f3cad6d3700ee2041ed1d4cb7c49ab
ToppCellE18.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP12 FOLR2 MCM10 CLEC10A

9.60e-0515469479ebda35dd1719e157738d7c13e5b8ccc3991f03
ToppCellHealthy_Control-Myeloid-Macrophages-FCN1_high|Healthy_Control / Condition, Lineage, Cell class and cell subclass

BAZ1A RNF19B TNFAIP6 TEC

9.84e-05155694cd2ccb4632713b4def3a1064599b78207e2e44c0
ToppCellFrontal_cortex-Macroglia-OLIGODENDROCYTE-O2-Tnr-Oligodendrocyte.Tnf.Ptgds_(Ptgds)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

HGD TNFAIP6 C8A

1.00e-045869392afa343d2e80ea076533ab2e45f63a4638f37aa
ToppCellFrontal_cortex-Macroglia-OLIGODENDROCYTE-O2-Tnr-Oligodendrocyte.Tnf.Ptgds_(Ptgds)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

HGD TNFAIP6 C8A

1.00e-0458693f840029b1fcca7570aa836eded41dc33ca5aa0a6
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMC3 PLAT TNFAIP6 FHL2

1.03e-04157694beab0ac47202266b04543c02cfcdda012375e879
ToppCelldroplet-Bladder-Unstain-18m-Hematologic-macrophage|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOLR2 CD37 DNAH2 CLEC10A

1.06e-04158694e5e7b2d609973f1dd4fe7dc62bb69422268ea801
ToppCelldroplet-Lung-nan-3m-Lymphocytic-Zbtb32+_B|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDIA4 CD37 PRMT7 TEC

1.06e-0415869466c011e9de002224f70725dfe8e7871c8d304492
ToppCelldroplet-Bladder-nan-24m-Hematologic-macrophage|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOLR2 CD37 DNAH2 CLEC10A

1.06e-041586944a9d4706876f6e86fc5d63ad6dc7df1b4a5cfd9e
ToppCell(03)_Secretory-(3)_72hpi|(03)_Secretory / shred by cell type and Timepoint

PDIA4 TGM2 PLAT FHL2

1.06e-0415869420563d03183b63aafc9c389f3f03781140702249
ToppCelldroplet-Bladder-Unstain-18m-Hematologic-leukocyte|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOLR2 CD37 DNAH2 CLEC10A

1.09e-0415969489b5e895e95cdd654edd471bde9b6887939b3503
ToppCelldroplet-Bladder-Unstain-18m-Hematologic|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOLR2 CD37 DNAH2 CLEC10A

1.09e-04159694a80b4637a74bcc6f213d584aba2c727a983eedb3
ToppCellCV-Mild-4|CV / Virus stimulation, Condition and Cluster

NELL2 RHOD PLAT SIPA1L2

1.11e-04160694be89efeeecb0de96ce136a7a62738f15dc0badb2
ToppCellPND01-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RNF19B CNTNAP1 TEC SYT13

1.14e-0416169452556b89808e551540f33a13f57417a6696c2438
ToppCellPND01-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RNF19B CNTNAP1 TEC SYT13

1.14e-0416169454f156cf2bd5a6ba9a78ec4e3ee28b89998aec2e
ToppCellPND01-Immune-Immune_Myeloid-Megakaryocyte/Platelet|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RNF19B CNTNAP1 TEC SYT13

1.14e-04161694242891be849a4398fe8bea44875ae1ba57950944
ToppCell10x5'-Liver-Lymphocytic_Invariant-Inducer-like-ILC3|Liver / Manually curated celltypes from each tissue

TGM2 LRP12 PLAT FHL1

1.19e-041636947f61483eeb1fde21843c6391468e13cb0cc2a89f
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_1|E16.5-samps / Age Group, Lineage, Cell class and subclass

TGM2 DTNA MRC2 FHL1

1.19e-04163694f1ec2625b52664308968b01d8e0275e1e0751480
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_3|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

XYLT2 TSPAN8 PLAT MCM10

1.22e-04164694583dda853cee9491dbdcb228c23d8deadc20eb08
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

FSIP2 BAZ1A PLAT ZNF619

1.25e-04165694436ce4bc75e1ba4351c439ccad19f84ad5bcb92f
ToppCellsaliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

FSIP2 BAZ1A PLAT ZNF619

1.25e-04165694242bdb7654f415391fb8e9bdc06412c7eee9c97e
ToppCellBasal_cells-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

TRIM49 LRP4 FHL2 TRIM49B

1.28e-0416669423c04d1fba0c1733ccd0e4378fae2edde4fd0a7b
ToppCellPBMC-Control-Hematopoietic-Platelet-Platelet-plt_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HGD LRP12 DENND2C FHL2

1.34e-041686942d056cfbb470a088a0682576753535fb4528d48f
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-8|TCGA-Thryoid / Sample_Type by Project: Shred V9

NELL2 CNTNAP1 LRP4 SIPA1L2

1.34e-0416869400646601548b0fee42ae16bfa5e93603bc7c5129
ToppCellPBMC-Control-Hematopoietic-Platelet-Platelet-plt_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

HGD LRP12 DENND2C FHL2

1.34e-041686942f69e248c6fab1421c0081e01e1920e6ffcde344
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LAMA2 TNFAIP6 FHL1 FHL2

1.34e-041686944b2d29a7843bf45922038c093ca7ec0600756adc
ToppCelldroplet-Thymus-nan-18m-Myeloid-Macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DTNA TSPAN8 LAMC3 CLEC10A

1.37e-041696944ac21e8199de4b6917eacadc56fffc6d886ee643
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MRC2 LAMA2 LAMC3 FHL2

1.37e-04169694a84490724a206c9bbb145f7ce08613f91d100ac4
ToppCellCOVID-19-Heart-CM_+_Macrophage|COVID-19 / Disease (COVID-19 only), tissue and cell type

DTNA LAMA2 FHL1 FHL2

1.40e-041706943f15242a1d3e4e9871d9170b2ef05842fb609c29
ToppCelldroplet-Fat-Scat|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

P4HB FOLR2 TNFAIP6 CLEC10A

1.40e-04170694de722bea7527d6ad11b69f8e9589638f52854beb
ToppCellwk_20-22-Hematologic-Meg-ery-Megakaryocyte|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

HGD LRP12 DENND2C FHL2

1.40e-04170694eace4dd09cdbde0fa40a6aa0f3dba1114d0ce475
ToppCellfacs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l15|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

LAMA2 LAMC3 SNUPN FHL2

1.47e-04172694de4961f4037c439d3e0ec706a257b0ec17f4d5be
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Microglia/Mac|metastatic_Lymph_Node / Location, Cell class and cell subclass

TMEM201 FOLR2 ZNF619 ZNRF2

1.47e-04172694f673a2e697b46e7cfa4186cb3fb2b98e3c83703e
ToppCell367C-Myeloid-Monocyte-CD16+_Monocyte|Monocyte / Donor, Lineage, Cell class and subclass (all cells)

LRP12 RNF19A AGL LAMA2

1.47e-04172694fb8ab2576b5c38db63573a3bf46b8d9d634c4999
ToppCell343B-Myeloid-Dendritic-pDC|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

TSPAN8 ZKSCAN8 ZNF236 ZNRF2

1.57e-04175694b30589ff9dc18e745afe61f289e6d576c9c6c6b2
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PDIA4 TGM2 LAMA2 FHL2

1.60e-04176694fcf324e6402819683f95e0dd94bf1f777c7f4c76
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MRC2 LAMA2 NBEA TNFAIP6

1.64e-04177694bd602db857f37869ef76d14c05ef522c509f08ee
ToppCell356C-Fibroblasts-Fibroblast-G|356C / Donor, Lineage, Cell class and subclass (all cells)

TGM2 LMCD1 PTPRQ FHL1

1.64e-041776948220cc2fc0ee8764a67a3be51d75248be2453040
ToppCell356C-Fibroblasts-Fibroblast-G-|356C / Donor, Lineage, Cell class and subclass (all cells)

TGM2 LMCD1 PTPRQ FHL1

1.64e-041776947617270f49cd6b7ba66db72d20560cee985012b2
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-myocytic-SMC_(PART1/CAPN3+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ANKRD44 TGM2 PLAT FHL2

1.68e-041786940fb36679cddc9ed8f4b5b34e174d5133c2ea1c76
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MRC2 LAMA2 LAMC3 FHL2

1.68e-0417869478a0c6340001a77f5b2d890b6263f574af2e72da
ToppCellPND28-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZDHHC2 MCM10 CLEC10A HR

1.71e-041796949dea57494d59abd6e8abf34e31faf53462ea0fa0
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DTNA CNTNAP1 LRP4 FHL1

1.71e-0417969402c90d8306016365ed811f0c63cfb3ac7b85464c
DrugPivampicillin [33817-20-8]; Up 200; 8.6uM; MCF7; HT_HG-U133A

MALT1 TGM2 RNF19B ADAM30 PLAT FHL1 TRIM36

1.44e-061966573506_UP
DrugRisperidone [106266-06-2]; Down 200; 9.8uM; HL60; HT_HG-U133A

XYLT2 MAP4K3 RNF19B ZMYND8 ZNF236 TRIM36

1.82e-051926562947_DN
DrugTestosterone propionate [57-85-2]; Up 200; 11.6uM; PC3; HT_HG-U133A

DTNA MRC2 ZMYND8 LAMA2 MUC2 HR

1.87e-051936564676_UP
DrugBoldine [476-70-0]; Up 200; 12.2uM; MCF7; HT_HG-U133A

TGM2 MRC2 ADAM30 PLAT CLEC4M FHL1

1.98e-051956562804_UP
DrugEthynylestradiol 3-methyl ether [72-33-3]; Up 200; 12.8uM; MCF7; HT_HG-U133A

TGM2 LRP12 RNF19A LRP4 FHL1 MUC2

1.98e-051956563346_UP
DrugHeliotrine [303-33-3]; Down 200; 12.8uM; MCF7; HT_HG-U133A

TGM2 LRP12 RNF19B PLAT FHL1 HR

2.04e-051966564739_DN
DrugMelatonin [73-31-4]; Up 200; 17.2uM; MCF7; HT_HG-U133A

LRP12 DTNA LRP4 FHL1 TRIM36 HR

2.10e-051976563293_UP
Drug5149715; Down 200; 10uM; MCF7; HT_HG-U133A_EA

XYLT2 MALT1 RNF19A ZMYND8 FHL1 HR

2.16e-05198656890_DN
Drug6-Furfurylaminopurine [525-79-1]; Up 200; 18.6uM; MCF7; HT_HG-U133A

TGM2 LRP12 MRC2 ZKSCAN8 CLEC4M HR

2.16e-051986566073_UP
DrugSulfamerazine [127-79-7]; Up 200; 15.2uM; MCF7; HT_HG-U133A

NELL2 LAMA2 C8A FHL1 MUC2 HR

2.16e-051986566036_UP
DrugHexamethonium dibromide dihydrate [55-97-0]; Up 200; 10uM; MCF7; HT_HG-U133A

TGM2 RNF19B CNTNAP1 C8A TRIM36 HR

2.22e-051996561482_UP
DrugdbrB

TGM2 TEC

2.40e-053652CID000506145
DrugBay-13-9952

NETO1 PLAT

4.80e-054652CID006918333
Diseasetyrosine-protein kinase TEC measurement

TEC TEC

3.22e-054692EFO_0020830
DiseaseLiver Cirrhosis, Experimental

ZDHHC2 FOLR2 AGL TSPAN8 PLAT NBEA FHL1 FHL2 SMAD2

7.79e-05774699C0023893
Diseaseoctadecanedioate measurement

LAMA2 LAMC3

2.40e-0410692EFO_0021056
Diseaseglucose-dependent insulinotropic peptide measurement, glucose tolerance test

ADAM30 CLEC10A

4.82e-0414692EFO_0004307, EFO_0008464
Diseasebipolar disorder, sex interaction measurement

SIPA1L2 FHL2

8.05e-0418692EFO_0008343, MONDO_0004985
Diseasecystathionine measurement

TEC TEC

8.98e-0419692EFO_0010474

Protein segments in the cluster

PeptideGeneStartEntry
WNQAPKLHYCLDYDC

SYT13

156

Q7L8C5
PNMCEHDGRCYQSWD

CNTNAP1

546

P78357
EWTDCFPCQDKKYRH

C8A

46

P07357
WCNGTSHQCPEDRYV

ADAM21

476

Q9UKJ8
VHKPNRWCFYSSCEQ

BAZ1A

886

Q9NRL2
NCVYPWDENHCKEKR

NETO1

316

Q8TDF5
HPSVYLNGNWLCCQE

RASA2

716

Q15283
WCQKCCVVRNPYTGH

MAP4K3

671

Q8IVH8
EQQRCDGYWHCPNGR

LRP12

391

Q9Y561
CDSRANCINLPGWYH

NELL2

566

Q99435
NCINLPGWYHCECRD

NELL2

571

Q99435
EYSHAVCCLQPRFWK

IRF1-AS1

61

Q8N8D9
LCCRATGHPFVQYQW

MALT1

146

Q9UDY8
AEKCQQDPESCWYFH

MMS19

606

Q96T76
IPNHWFTKGNTCFEC

FSIP2

1031

Q5CZC0
WVKFDIRGHCPCQAD

HR

681

O43593
PFYWCESKGVCVHGN

MUC2

4916

Q02817
ECEPSWQPFQGHCYR

MRC2

381

Q9UBG0
WQPFQGHCYRLQAEK

MRC2

386

Q9UBG0
GHWNYPRCNLCDCFL

LAMA2

1096

P24043
WHDGVKRFFKCPCGN

MCM10

806

Q7L590
CFKDNQGYTPLHWAC

ANKRD44

766

Q8N8A2
KNVFVEFYAPWCGHC

P4HB

386

P07237
RAGYNKQWHPTCFVC

LMCD1

261

Q9NZU5
QCFEKGRIRCHQYWP

PTPRQ

2136

Q9UMZ3
NIFNRWYPEVNHFCK

RHOD

106

O00212
YQDQPWHADCFVCVT

FHL1

176

Q13642
NRKNCHCMYGWAPPF

ADAM30

646

Q9UKF2
EGGCCWNPHCKQAVY

PRMT7

636

Q9NVM4
YNFNWDHCGKMEPAC

FOLR2

76

P14207
WCPKDFGVRYNCHQE

DENND2C

41

Q68D51
YREQPWHKECFVCTA

FHL2

176

Q14192
CHNYQLCQDCFWRGH

DTNA

261

Q9Y4J8
VCDCQYHFARWEDGK

DNAH2

391

Q9P225
VPQDGRNDFYCWVCH

ZMYND8

81

Q9ULU4
VQFQLRCCGWHYPQD

CD37

146

P11049
SRCLDENYHKCWEPL

HGD

416

Q93099
ASYCNECFKIHHPWG

TRIM36

176

Q9NQ86
GHSFCRPCFYLNWQD

TRIM49

31

P0CI25
EFCYHCKQIWHPNQT

RNF19B

236

Q6ZMZ0
HPKFWTDGSYQCCRQ

TEC

121

P42680
GFQHCVKYDFQPRKW

NBEA

311

Q8NFP9
RPWNCQRCFAHYDVQ

SIPA1L2

321

Q9P2F8
VLIEFYAPWCGHCKQ

PDIA4

546

P13667
LDVMCWRGHPFYDCQ

SNUPN

186

O95149
CKCWHGQLRCFPQAF

TDGF1

131

P13385
CQRPYHWVCEAGLGQ

CLEC10A

296

Q8IUN9
RHCPKDWTFFQGNCY

CLEC4M

266

Q9H2X3
NHGCQRVKYGQCWVF

TGM2

266

P21980
PCLCIYHKGCIDEWF

ZNRF2

216

Q8NHG8
EEAWYCPQCKQHREA

USP19

1076

O94966
ERWDAYCYNPHAKEC

TNFAIP6

121

P98066
HNYCRNPDRDSKPWC

PLAT

176

P00750
CGTEFCYHCKQIWHP

RNF19A

246

Q9NV58
NCNQRYGWHPATVCK

SMAD2

361

Q15796
GHSFCRPCFYLNWQD

TRIM49C

31

P0CI26
KPYKCNDCGNTFRHW

ZNF808

761

Q8N4W9
NRNCWDCPHCEQYNG

TMEM201

61

Q5SNT2
LCACGAEWYHEGNVK

RNF168

301

Q8IYW5
WFKCRNGHIYVIGDC

ZNFX1

1846

Q9P2E3
GHSFCRPCFYLNWQD

TRIM51G

31

A0A3B3IT33
GHSFCRPCFYLNWQD

TRIM49D1

31

C9J1S8
ENGVRWHVCPYCAKE

ZNF236

476

Q9UL36
HCPWVNNCVGFSNYK

ZDHHC2

156

Q9UIJ5
GHSFCRPCFYLNWKD

TRIM49B

31

A6NDI0
RFHTGEQLYKCNECW

ZNF619

376

Q8N2I2
CKCWHGQLRCFPQAF

TDGF1P3

131

P51864
YKHIVDWCGCSPNDF

XYLT2

471

Q9H1B5
WGNNFQHYPELCACL

TSPAN8

161

P19075
WRIHTGEKPYQCNVC

ZKSCAN8

341

Q15776
DKGPAAIEECCNWFH

AGL

361

P35573
GPHCERCQENFYHWD

LAMC3

361

Q9Y6N6
RCQENFYHWDPRMPC

LAMC3

366

Q9Y6N6
PCQNGYCIRSLWHCD

LRP4

116

O75096