Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzodiazepine receptor binding	RIMBP3 RIMBP3C RIMBP3B	5.93e-07	5	79	3	GO:0030156
GeneOntologyMolecularFunction	G protein-coupled photoreceptor activity	OPN1MW2 OPN1MW3 OPN1MW	2.62e-05	15	79	3	GO:0008020
GeneOntologyMolecularFunction	photoreceptor activity	OPN1MW2 OPN1MW3 OPN1MW	3.89e-05	17	79	3	GO:0009881
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OPN1MW2 OR52B4 IL12RB2 OPN1MW3 DRD1 ADRA2B PROKR2 P2RY2 MTNR1B TAAR3P OPN1MW PLXNB3 HCRTR2 S1PR4 GABRR3 SORL1	6.66e-05	1353	79	16	GO:0004888
GeneOntologyMolecularFunction	superoxide-generating NADPH oxidase activity	NOX4 NOX3	9.23e-05	4	79	2	GO:0106292
GeneOntologyMolecularFunction	phospholipid scramblase activity	ATG9B XKR8 ATG9A	9.97e-05	23	79	3	GO:0017128
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OPN1MW2 OR52B4 OPN1MW3 DRD1 ADRA2B PROKR2 P2RY2 MTNR1B TAAR3P OPN1MW HCRTR2 S1PR4	1.75e-04	884	79	12	GO:0004930
GeneOntologyMolecularFunction	calmodulin binding	IQCF2 CACNA1C MYO3A MYO1D CAMSAP3 CEP97	3.02e-04	230	79	6	GO:0005516
GeneOntologyMolecularFunction	microfilament motor activity	MYO3A MYO1D MYO3B	4.55e-04	38	79	3	GO:0000146
GeneOntologyMolecularFunction	phosphatidyl phospholipase B activity	ASPG PLA2G4B	8.31e-04	11	79	2	GO:0102545
GeneOntologyMolecularFunction	superoxide-generating NAD(P)H oxidase activity	NOX4 NOX3	9.94e-04	12	79	2	GO:0016175
GeneOntologyMolecularFunction	intramembrane lipid transporter activity	ATG9B XKR8 ATG9A	1.08e-03	51	79	3	GO:0140303
GeneOntologyMolecularFunction	catecholamine binding	DRD1 ADRA2B	1.17e-03	13	79	2	GO:1901338
GeneOntologyCellularComponent	photoreceptor disc membrane	OPN1MW2 OPN1MW3 OPN1MW	1.32e-04	26	80	3	GO:0097381
GeneOntologyCellularComponent	manchette	RIMBP3 RIMBP3C RIMBP3B	1.65e-04	28	80	3	GO:0002177
GeneOntologyCellularComponent	organelle envelope	RMDN3 SLC8B1 GSTK1 ATR COQ4 PLA2G4B INTS1 PHLPP1 ATG9A WDFY3 NDUFA4 CTDNEP1 GPAT2 GTF3C3 SORL1	3.16e-04	1435	80	15	GO:0031967
Domain	IQ	IQCF2 MYO3A MYO1D MYO3B CEP97	1.33e-05	71	80	5	PF00612
Domain	Autophagy-rel_prot_9	ATG9B ATG9A	1.81e-05	2	80	2	IPR007241
Domain	APG9	ATG9B ATG9A	1.81e-05	2	80	2	PF04109
Domain	IQ	IQCF2 MYO3A MYO1D MYO3B CEP97	2.52e-05	81	80	5	SM00015
Domain	IQ_motif_EF-hand-BS	IQCF2 MYO3A MYO1D MYO3B CEP97	4.20e-05	90	80	5	IPR000048
Domain	IQ	IQCF2 MYO3A MYO1D MYO3B CEP97	4.92e-05	93	80	5	PS50096
Domain	Opsin_red/grn	OPN1MW3 OPN1MW	5.42e-05	3	80	2	IPR000378
Domain	Cyt_b245_heavy_chain	NOX4 NOX3	1.08e-04	4	80	2	IPR000778
Domain	7TM_GPCR_Srsx	OPN1MW3 DRD1 ADRA2B MTNR1B HCRTR2	1.19e-04	112	80	5	SM01381
Domain	7tm_1	OR52B4 OPN1MW3 DRD1 ADRA2B PROKR2 P2RY2 MTNR1B TAAR3P OPN1MW HCRTR2 S1PR4	1.41e-04	677	80	11	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR52B4 OPN1MW3 DRD1 ADRA2B PROKR2 P2RY2 MTNR1B TAAR3P OPN1MW HCRTR2 S1PR4	1.56e-04	685	80	11	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR52B4 OPN1MW3 DRD1 ADRA2B PROKR2 P2RY2 MTNR1B TAAR3P OPN1MW HCRTR2 S1PR4	1.69e-04	691	80	11	PS50262
Domain	GPCR_Rhodpsn	OR52B4 OPN1MW3 DRD1 ADRA2B PROKR2 P2RY2 MTNR1B TAAR3P OPN1MW HCRTR2 S1PR4	1.71e-04	692	80	11	IPR000276
Domain	FATC	SMG1 ATR	1.80e-04	5	80	2	PF02260
Domain	FAT	SMG1 ATR	2.69e-04	6	80	2	PS51189
Domain	FATC	SMG1 ATR	2.69e-04	6	80	2	PS51190
Domain	PH_BEACH	WDFY3 LYST	2.69e-04	6	80	2	PF14844
Domain	FATC_dom	SMG1 ATR	2.69e-04	6	80	2	IPR003152
Domain	PIK_FAT	SMG1 ATR	2.69e-04	6	80	2	IPR014009
Domain	FATC	SMG1 ATR	2.69e-04	6	80	2	SM01343
Domain	NAD_binding_6	NOX4 NOX3	3.75e-04	7	80	2	PF08030
Domain	FAD_binding_8	NOX4 NOX3	3.75e-04	7	80	2	PF08022
Domain	FAD-bd_8	NOX4 NOX3	3.75e-04	7	80	2	IPR013112
Domain	Fe_red_NAD-bd_6	NOX4 NOX3	3.75e-04	7	80	2	IPR013121
Domain	PH-BEACH_dom	WDFY3 LYST	4.99e-04	8	80	2	IPR023362
Domain	-	WDFY3 LYST	4.99e-04	8	80	2	2.30.29.40
Domain	PH_BEACH	WDFY3 LYST	4.99e-04	8	80	2	PS51783
Domain	GPCR_Rhodpsn_7TM	OR52B4 OPN1MW3 DRD1 ADRA2B PROKR2 P2RY2 MTNR1B OPN1MW HCRTR2 S1PR4	5.65e-04	670	80	10	IPR017452
Domain	Myosin_head_motor_dom	MYO3A MYO1D MYO3B	5.73e-04	38	80	3	IPR001609
Domain	MYOSIN_MOTOR	MYO3A MYO1D MYO3B	5.73e-04	38	80	3	PS51456
Domain	Myosin_head	MYO3A MYO1D MYO3B	5.73e-04	38	80	3	PF00063
Domain	MYSc	MYO3A MYO1D MYO3B	5.73e-04	38	80	3	SM00242
Domain	BEACH_dom	WDFY3 LYST	6.40e-04	9	80	2	IPR000409
Domain	BEACH	WDFY3 LYST	6.40e-04	9	80	2	PS50197
Domain	Beach	WDFY3 LYST	6.40e-04	9	80	2	PF02138
Domain	-	WDFY3 LYST	6.40e-04	9	80	2	1.10.1540.10
Domain	Beach	WDFY3 LYST	6.40e-04	9	80	2	SM01026
Domain	WD40_repeat_CS	EED WDFY3 LYST FBXW7 WDR48	6.94e-04	164	80	5	IPR019775
Domain	OPSIN	OPN1MW3 OPN1MW	7.97e-04	10	80	2	PS00238
Domain	Opsin	OPN1MW3 OPN1MW	9.72e-04	11	80	2	IPR001760
Domain	Ferric_reduct	NOX4 NOX3	1.16e-03	12	80	2	PF01794
Domain	Fe3_Rdtase_TM_dom	NOX4 NOX3	1.16e-03	12	80	2	IPR013130
Domain	FN3	RIMBP3 IL12RB2 RIMBP3C RIMBP3B SORL1	1.64e-03	199	80	5	PS50853
Domain	WD40_repeat_dom	KNTC1 EED WDFY3 LYST FBXW7 WDR48	1.72e-03	297	80	6	IPR017986
Domain	PI3/4_kinase_CS	SMG1 ATR	1.83e-03	15	80	2	IPR018936
Domain	FN3_dom	RIMBP3 IL12RB2 RIMBP3C RIMBP3B SORL1	2.04e-03	209	80	5	IPR003961
Domain	-	SMG1 ATR	2.09e-03	16	80	2	1.10.1070.11
Domain	PI3Kc	SMG1 ATR	2.09e-03	16	80	2	SM00146
Domain	PI3/4_kinase_cat_dom	SMG1 ATR	2.65e-03	18	80	2	IPR000403
Domain	PI3_PI4_kinase	SMG1 ATR	2.65e-03	18	80	2	PF00454
Domain	PI3_4_KINASE_3	SMG1 ATR	2.65e-03	18	80	2	PS50290
Domain	PI3_4_KINASE_1	SMG1 ATR	2.65e-03	18	80	2	PS00915
Domain	PI3_4_KINASE_2	SMG1 ATR	2.65e-03	18	80	2	PS00916
Domain	Fd_Rdtase_FAD-bd	NOX4 NOX3	2.96e-03	19	80	2	IPR017927
Domain	FAD_FR	NOX4 NOX3	2.96e-03	19	80	2	PS51384
Domain	Riboflavin_synthase-like_b-brl	NOX4 NOX3	2.96e-03	19	80	2	IPR017938
Domain	-	EED WDFY3 LYST PLXNB3 FBXW7 WDR48	3.05e-03	333	80	6	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	EED WDFY3 LYST PLXNB3 FBXW7 WDR48	3.14e-03	335	80	6	IPR015943
Domain	ARM-type_fold	SMG1 ATR INTS1 FRYL WDFY3 LYST	3.33e-03	339	80	6	IPR016024
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	OPN1MW2 OPN1MW3 DRD1 ADRA2B PROKR2 P2RY2 MTNR1B TAAR3P HCRTR2 S1PR4	1.25e-06	333	60	10	MM14963
Pathway	REACTOME_GPCR_LIGAND_BINDING	OPN1MW2 OPN1MW3 DRD1 ADRA2B PROKR2 P2RY2 MTNR1B TAAR3P HCRTR2 S1PR4	1.21e-05	430	60	10	MM15160
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	DRD1 ADRA2B PROKR2 P2RY2 MTNR1B OPN1MW HCRTR2 S1PR4	7.34e-05	330	60	8	M18334
Pathway	WP_NF1_COPY_NUMBER_VARIATION_SYNDROME	EED ATR ATAD5 EIF3A WDR48	9.81e-05	109	60	5	M48084
Pathway	WP_GPCRS_NONODORANT	DRD1 ADRA2B PROKR2 P2RY2 MTNR1B HCRTR2 S1PR4	1.29e-04	266	60	7	MM15843
Pathway	REACTOME_SIGNALING_BY_GPCR	OPN1MW2 OPN1MW3 DRD1 ADRA2B PROKR2 P2RY2 MTNR1B TAAR3P HCRTR2 S1PR4	3.60e-04	646	60	10	MM14962
Pathway	REACTOME_THE_RETINOID_CYCLE_IN_CONES_DAYLIGHT_VISION	OPN1MW2 OPN1MW3	4.91e-04	8	60	2	MM14880
Pathway	WP_SLEEP_REGULATION	DRD1 MTNR1B HCRTR2	5.56e-04	38	60	3	M39504
Pathway	REACTOME_FANCONI_ANEMIA_PATHWAY	ATR FANCI WDR48	6.01e-04	39	60	3	M14990
Pathway	REACTOME_GPCR_LIGAND_BINDING	DRD1 ADRA2B PROKR2 P2RY2 MTNR1B OPN1MW HCRTR2 S1PR4	7.28e-04	463	60	8	M507
Pathway	REACTOME_AMINE_LIGAND_BINDING_RECEPTORS	DRD1 ADRA2B TAAR3P	7.48e-04	42	60	3	MM14971
Pathway	REACTOME_OPSINS	OPN1MW2 OPN1MW3	7.84e-04	10	60	2	MM15063
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	DRD1 ADRA2B P2RY2 MTNR1B OPN1MW HCRTR2	8.08e-04	260	60	6	M39397
Pathway	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	DRD1 ADRA2B P2RY2 MTNR1B HCRTR2 S1PR4	1.02e-03	272	60	6	M13380
Pathway	PID_FANCONI_PATHWAY	ATR FANCI WDR48	1.04e-03	47	60	3	M1
Pubmed	Cloning and distribution of myosin 3B in the mouse retina: differential distribution in cone outer segments.	OPN1MW2 OPN1MW3 MYO3A MYO3B	9.50e-10	7	81	4	19332056
Pubmed	Regulation of the Fanconi anemia pathway by a SUMO-like delivery network.	ATAD5 FANCI WDR48	1.22e-08	3	81	3	21896657
Pubmed	Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.	RIMBP3 RIMBP3C TDRD6 RIMBP3B	2.68e-08	14	81	4	17662146
Pubmed	Human L- and M-opsins restore M-cone function in a mouse model for human blue cone monochromacy.	OPN1MW2 OPN1MW3 OPN1MW	4.86e-08	4	81	3	29386880
Pubmed	RIM-BP3 is a manchette-associated protein essential for spermiogenesis.	RIMBP3 RIMBP3C RIMBP3B	4.86e-08	4	81	3	19091768
Pubmed	Structure and evolution of RIM-BP genes: identification of a novel family member.	RIMBP3 RIMBP3C RIMBP3B	1.21e-07	5	81	3	17855024
Pubmed	Molecular genetics of human color vision: the genes encoding blue, green, and red pigments.	OPN1MW2 OPN1MW3 OPN1MW	1.21e-07	5	81	3	2937147
Pubmed	Promotion of RAD51-Mediated Homologous DNA Pairing by the RAD51AP1-UAF1 Complex.	ATAD5 FANCI WDR48	2.42e-07	6	81	3	27239033
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SLC8B1 COQ4 PLA2G4B FANCI PIEZO1 DEF6 INTS1 FRYL ATG9A WDFY3 CTDNEP1 LYST MED13	1.59e-06	1105	81	13	35748872
Pubmed	Mouse class III myosins: kinase activity and phosphorylation sites.	MYO3A MYO3B	5.36e-06	2	81	2	21895655
Pubmed	Hydrogen/Deuterium Exchange Mass Spectrometry of Human Green Opsin Reveals a Conserved Pro-Pro Motif in Extracellular Loop 2 of Monostable Visual G Protein-Coupled Receptors.	OPN1MW2 OPN1MW	5.36e-06	2	81	2	28402104
Pubmed	Defective colour vision associated with a missense mutation in the human green visual pigment gene.	OPN1MW2 OPN1MW	5.36e-06	2	81	2	1302020
Pubmed	ATG9B is a tissue-specific homotrimeric lipid scramblase that can compensate for ATG9A.	ATG9B ATG9A	5.36e-06	2	81	2	37938170
Pubmed	Position of a 'green-red' hybrid gene in the visual pigment array determines colour-vision phenotype.	OPN1MW2 OPN1MW	5.36e-06	2	81	2	10319869
Pubmed	Extinction of Contextual Cocaine Memories Requires Cav1.2 within D1R-Expressing Cells and Recruits Hippocampal Cav1.2-Dependent Signaling Mechanisms.	CACNA1C DRD1	5.36e-06	2	81	2	29089442
Pubmed	Impact of the Motor and Tail Domains of Class III Myosins on Regulating the Formation and Elongation of Actin Protrusions.	MYO3A MYO3B	5.36e-06	2	81	2	27582493
Pubmed	Progenitor death drives retinal dysplasia and neuronal degeneration in a mouse model of ATRIP-Seckel syndrome.	OPN1MW2 OPN1MW3 ATR	9.68e-06	18	81	3	32994318
Pubmed	Molecular determinants of human red/green color discrimination.	OPN1MW2 OPN1MW	1.60e-05	3	81	2	8185948
Pubmed	X-linked cone dystrophy caused by mutation of the red and green cone opsins.	OPN1MW2 OPN1MW	1.60e-05	3	81	2	20579627
Pubmed	Expression of red/green-cone opsin mutants K82E, P187S, M273K result in unique pathobiological perturbations to cone structure and function.	OPN1MW2 OPN1MW3	1.60e-05	3	81	2	38410159
Pubmed	Chloride-dependent spectral tuning mechanism of L-group cone visual pigments.	OPN1MW2 OPN1MW3	1.60e-05	3	81	2	23350963
Pubmed	Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradiance.	OPN1MW2 OPN1MW3	1.60e-05	3	81	2	20471354
Pubmed	Multiple hypothalamic cell populations encoding distinct visual information.	OPN1MW2 OPN1MW3	1.60e-05	3	81	2	21224225
Pubmed	Circadian Regulation of the Rod Contribution to Mesopic Vision in Mice.	OPN1MW2 OPN1MW3	1.60e-05	3	81	2	36216501
Pubmed	Spectral tuning of a circadian photopigment in a subterranean 'blind' mammal (Spalax ehrenbergi).	OPN1MW2 OPN1MW3	1.60e-05	3	81	2	10567724
Pubmed	Regulation of the Fanconi Anemia DNA Repair Pathway by Phosphorylation and Monoubiquitination.	ATR FANCI	1.60e-05	3	81	2	34828369
Pubmed	Extensive cone-dependent spectral opponency within a discrete zone of the lateral geniculate nucleus supporting mouse color vision.	OPN1MW2 OPN1MW3	1.60e-05	3	81	2	34111401
Pubmed	Myosin IIIB uses an actin-binding motif in its espin-1 cargo to reach the tips of actin protrusions.	MYO3A MYO3B	1.60e-05	3	81	2	22264607
Pubmed	ATAD5 suppresses centrosome over-duplication by regulating UAF1 and ID1.	ATAD5 WDR48	1.60e-05	3	81	2	32594826
Pubmed	Genetically engineered mice with an additional class of cone photoreceptors: implications for the evolution of color vision.	OPN1MW2 OPN1MW3	1.60e-05	3	81	2	14500905
Pubmed	The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation.	ATR PIEZO1	1.60e-05	3	81	2	34158506
Pubmed	Gene-based Therapy in a Mouse Model of Blue Cone Monochromacy.	OPN1MW2 OPN1MW3	1.60e-05	3	81	2	28751656
Pubmed	Rescue of M-cone Function in Aged Opn1mw-/- Mice, a Model for Late-Stage Blue Cone Monochromacy.	OPN1MW2 OPN1MW3	1.60e-05	3	81	2	31469404
Pubmed	The molecular genetics and evolution of red and green color vision in vertebrates.	OPN1MW2 OPN1MW3	1.60e-05	3	81	2	11545071
Pubmed	Mechanisms of spectral tuning in the mouse green cone pigment.	OPN1MW2 OPN1MW3	1.60e-05	3	81	2	9238068
Pubmed	Emergence of novel color vision in mice engineered to express a human cone photopigment.	OPN1MW2 OPN1MW3	1.60e-05	3	81	2	17379811
Pubmed	UBE2T regulates FANCI monoubiquitination to promote NSCLC progression by activating EMT.	FANCI WDR48	1.60e-05	3	81	2	35703356
Pubmed	The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways.	SMG1 ATR	1.60e-05	3	81	2	15279777
Pubmed	Endothelial nitric-oxide synthase antisense (NOS3AS) gene encodes an autophagy-related protein (APG9-like2) highly expressed in trophoblast.	ATG9B ATG9A	1.60e-05	3	81	2	15755735
Pubmed	Co-expression of murine opsins facilitates identifying the site of cone adaptation.	OPN1MW2 OPN1MW3	1.60e-05	3	81	2	12511072
Pubmed	Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5.	NOX4 NOX3	1.60e-05	3	81	2	11376945
Pubmed	Myosin III-mediated cross-linking and stimulation of actin bundling activity of Espin.	MYO3A MYO3B	1.60e-05	3	81	2	26785147
Pubmed	The Pem homeobox gene is X-linked and exclusively expressed in extraembryonic tissues during early murine development.	OPN1MW2 OPN1MW3	1.60e-05	3	81	2	7958444
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	SMIM24 IQCF2 KNTC1 CACNA1C SMG1 GSTK1 MYO1D TAF1B CAMSAP3 EIF3A PEX11A LYST MED13	2.75e-05	1442	81	13	35575683
Pubmed	Aberrant methylation of ATG2B, ATG4D, ATG9A and ATG9B CpG island promoter is associated with decreased mRNA expression in sporadic breast carcinoma.	ATG9B ATG9A	3.20e-05	4	81	2	27265029
Pubmed	Structural basis of FANCD2 deubiquitination by USP1-UAF1.	FANCI WDR48	3.20e-05	4	81	2	33795880
Pubmed	Visual responses in the dorsal lateral geniculate nucleus at early stages of retinal degeneration in rd1 PDE6β mice.	OPN1MW2 OPN1MW3	3.20e-05	4	81	2	31461375
Pubmed	Stereocilia-staircase spacing is influenced by myosin III motors and their cargos espin-1 and espin-like.	MYO3A MYO3B	3.20e-05	4	81	2	26926603
Pubmed	Murine and bovine blue cone pigment genes: cloning and characterization of two new members of the S family of visual pigments.	OPN1MW2 OPN1MW3	3.20e-05	4	81	2	8088841
Pubmed	Modulation of Fast Narrowband Oscillations in the Mouse Retina and dLGN According to Background Light Intensity.	OPN1MW2 OPN1MW3	3.20e-05	4	81	2	28103478
Pubmed	Molecular biology of the visual pigments.	OPN1MW2 OPN1MW	3.20e-05	4	81	2	3303660
Pubmed	Cones Support Alignment to an Inconsistent World by Suppressing Mouse Circadian Responses to the Blue Colors Associated with Twilight.	OPN1MW2 OPN1MW3	3.20e-05	4	81	2	31846668
Pubmed	Constitutive NADPH oxidase 4 activity resides in the composition of the B-loop and the penultimate C terminus.	NOX4 NOX3	3.20e-05	4	81	2	22277655
Pubmed	Melanopsin-driven increases in maintained activity enhance thalamic visual response reliability across a simulated dawn.	OPN1MW2 OPN1MW3	3.20e-05	4	81	2	26438865
Pubmed	Light/dark translocation of alphatransducin in mouse photoreceptor cells expressing G90D mutant opsin.	OPN1MW2 OPN1MW3	3.20e-05	4	81	2	17249565
Pubmed	Structural and functional rescue of cones carrying the most common cone opsin C203R missense mutation.	OPN1MW2 OPN1MW3	3.20e-05	4	81	2	38060327
Pubmed	Contribution of M-opsin-based color vision to refractive development in mice.	OPN1MW2 OPN1MW3	3.20e-05	4	81	2	34126082
Pubmed	Physiological features of the S- and M-cone photoreceptors of wild-type mice from single-cell recordings.	OPN1MW2 OPN1MW3	3.20e-05	4	81	2	16567464
Pubmed	S-opsin knockout mice with the endogenous M-opsin gene replaced by an L-opsin variant.	OPN1MW2 OPN1MW3	3.20e-05	4	81	2	24801621
Pubmed	Melanopsin Contributions to the Representation of Images in the Early Visual System.	OPN1MW2 OPN1MW3	3.20e-05	4	81	2	28528909
Pubmed	FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway.	ATR FANCI	3.20e-05	4	81	2	18931676
Pubmed	Amplification of the inflammatory cellular redox state by human immunodeficiency virus type 1-immunosuppressive tat and gp160 proteins.	NOX4 NOX3	3.20e-05	4	81	2	9882350
Pubmed	Melanopsin-driven light adaptation in mouse vision.	OPN1MW2 OPN1MW3	3.20e-05	4	81	2	25308073
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	DEF6 INTS1 CAMSAP3 MED13 GTF3C3 WDR48	4.30e-05	272	81	6	31010829
Pubmed	Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal Cell Proliferation and Photoreceptor Maintenance.	OPN1MW2 OPN1MW3 ATR	4.72e-05	30	81	3	37048108
Pubmed	Noncoding Mutations in a Thyroid Hormone Receptor Gene That Impair Cone Photoreceptor Function.	OPN1MW2 OPN1MW3	5.33e-05	5	81	2	36631163
Pubmed	Using Silent Substitution to Track the Mesopic Transition From Rod- to Cone-Based Vision in Mice.	OPN1MW2 OPN1MW3	5.33e-05	5	81	2	26818794
Pubmed	A common integration locus in type B retrovirus-induced thymic lymphomas.	OPN1MW2 OPN1MW3	5.33e-05	5	81	2	1333116
Pubmed	A distinct contribution of short-wavelength-sensitive cones to light-evoked activity in the mouse pretectal olivary nucleus.	OPN1MW2 OPN1MW3	5.33e-05	5	81	2	22090509
Pubmed	Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions.	OPN1MW2 OPN1MW3	5.33e-05	5	81	2	10723722
Pubmed	Macrophage autophagy in immunity to Cryptococcus neoformans and Candida albicans.	ATG9B ATG9A	5.33e-05	5	81	2	22710871
Pubmed	Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors.	OPN1MW2 OPN1MW3	5.33e-05	5	81	2	27033727
Pubmed	Impaired OXPHOS complex III in breast cancer.	NOX4 NOX3	5.33e-05	5	81	2	21901141
Pubmed	Transfer of intracellular HIV Nef to endothelium causes endothelial dysfunction.	NOX4 NOX3	5.33e-05	5	81	2	24608713
Pubmed	Melanopsin-based brightness discrimination in mice and humans.	OPN1MW2 OPN1MW3	5.33e-05	5	81	2	22633808
Pubmed	The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning.	OPN1MW2 OPN1MW3	5.33e-05	5	81	2	11055434
Pubmed	Enhancer/promoter activities of the long/middle wavelength-sensitive opsins of vertebrates mediated by thyroid hormone receptor β2 and COUP-TFII.	OPN1MW2 OPN1MW3	5.33e-05	5	81	2	24058409
Pubmed	Variations in photoreceptor throughput to mouse visual cortex and the unique effects on tuning.	OPN1MW2 OPN1MW3	5.33e-05	5	81	2	34099749
Pubmed	Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1.	ATAD5 WDR48	5.33e-05	5	81	2	20147293
Pubmed	ATR-mediated phosphorylation of FANCI regulates dormant origin firing in response to replication stress.	ATR FANCI	5.33e-05	5	81	2	25843623
Pubmed	Deubiquitinating enzyme Usp12 regulates the interaction between the androgen receptor and the Akt pathway.	PHLPP1 WDR48	7.99e-05	6	81	2	25216524
Pubmed	FANCI is a negative regulator of Akt activation.	FANCI PHLPP1	7.99e-05	6	81	2	27097374
Pubmed	A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor.	P2RY2 MTNR1B	7.99e-05	6	81	2	22754043
Pubmed	Functional comparison of rod and cone Gα(t) on the regulation of light sensitivity.	OPN1MW2 OPN1MW3	7.99e-05	6	81	2	23288843
Pubmed	GRK1-dependent phosphorylation of S and M opsins and their binding to cone arrestin during cone phototransduction in the mouse retina.	OPN1MW2 OPN1MW	7.99e-05	6	81	2	12853434
Pubmed	ATR-ATRIP kinase complex triggers activation of the Fanconi anemia DNA repair pathway.	ATR FANCI	7.99e-05	6	81	2	22258451
Pubmed	Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release.	P2RY2 PIEZO1	7.99e-05	6	81	2	27797339
Pubmed	Reduced levels of dystrophin associated proteins in the brains of mice deficient for Dp71.	OPN1MW2 OPN1MW3	7.99e-05	6	81	2	8872469
Pubmed	A thyroid hormone receptor that is required for the development of green cone photoreceptors.	OPN1MW2 OPN1MW3	7.99e-05	6	81	2	11138006
Pubmed	Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase.	OPN1MW2 OPN1MW3	7.99e-05	6	81	2	10395695
Pubmed	Cooperative induction of CXCL10 involves NADPH oxidase: Implications for HIV dementia.	NOX4 NOX3	7.99e-05	6	81	2	19941336
Pubmed	The NADPH oxidase NOX4 drives cardiac differentiation: Role in regulating cardiac transcription factors and MAP kinase activation.	NOX4 NOX3	7.99e-05	6	81	2	16775014
Pubmed	Transient expression of thyroid hormone nuclear receptor TRbeta2 sets S opsin patterning during cone photoreceptor genesis.	OPN1MW2 OPN1MW3	7.99e-05	6	81	2	17436273
Pubmed	Telomere-related markers for the pseudoautosomal region of the mouse genome.	OPN1MW2 OPN1MW3	7.99e-05	6	81	2	1549575
Pubmed	An approach based on a genome-wide association study reveals candidate loci for narcolepsy.	KNTC1 CACNA1C OR52B4 DRD1 PHLPP1	9.10e-05	193	81	5	20677014
Pubmed	Placentation defects are highly prevalent in embryonic lethal mouse mutants.	SMG1 COQ4 CAMSAP3 FRYL	1.01e-04	103	81	4	29539633
Pubmed	Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.	OPN1MW2 DRD1 ADRA2B P2RY2 TAAR3P	1.08e-04	200	81	5	18240029
Pubmed	Retarded developmental expression and patterning of retinal cone opsins in hypothyroid mice.	OPN1MW2 OPN1MW3	1.12e-04	7	81	2	18974269
Pubmed	Genetic and physical mapping of a gene encoding a methyl CpG binding protein, Mecp2, to the mouse X chromosome.	OPN1MW2 OPN1MW3	1.12e-04	7	81	2	8001979
Pubmed	NeuroD1 regulates expression of thyroid hormone receptor 2 and cone opsins in the developing mouse retina.	OPN1MW2 OPN1MW3	1.12e-04	7	81	2	18199774
Cytoband	Ensembl 112 genes in cytogenetic band chrXq28	OPN1MW2 OPN1MW3 AFF2 OPN1MW PLXNB3	3.95e-05	213	81	5	chrXq28
Cytoband	Xq28	OPN1MW2 AFF2 OPN1MW PLXNB3	2.76e-04	176	81	4	Xq28
Cytoband	22q11.21	RIMBP3 RIMBP3C RIMBP3B	1.02e-03	111	81	3	22q11.21
Cytoband	2q11.1	ADRA2B GPAT2	1.13e-03	28	81	2	2q11.1
Cytoband	Ensembl 112 genes in cytogenetic band chr15q15	RMDN3 EXD1 PLA2G4B	2.29e-03	147	81	3	chr15q15
Cytoband	Ensembl 112 genes in cytogenetic band chr11q14	EED MTNR1B NOX4	2.70e-03	156	81	3	chr11q14
Cytoband	15q15.1	RMDN3 EXD1	3.16e-03	47	81	2	15q15.1
Cytoband	Ensembl 112 genes in cytogenetic band chr3q11	CLDND1 GABRR3	4.15e-03	54	81	2	chr3q11
Cytoband	15q26.1	FANCI PEX11A	4.15e-03	54	81	2	15q26.1
Cytoband	Ensembl 112 genes in cytogenetic band chr15q26	FANCI LRRC28 PEX11A	5.88e-03	206	81	3	chr15q26
Cytoband	2q35	RETREG2 ATG9A	8.68e-03	79	81	2	2q35
Cytoband	12q24.31	KNTC1 POP5	8.89e-03	80	81	2	12q24.31
GeneFamily	Opsin receptors	OPN1MW2 OPN1MW3 OPN1MW	4.32e-06	11	55	3	215
GeneFamily	Myosins, class III\|Deafness associated genes	MYO3A MYO3B	9.09e-06	2	55	2	1099
GeneFamily	WD repeat domain containing\|BEACH domain containing	WDFY3 LYST	3.23e-04	9	55	2	1230
GeneFamily	WD repeat domain containing	EED WDFY3 LYST FBXW7 WDR48	1.18e-03	262	55	5	362
GeneFamily	Autophagy related	ATG9B ATG9A	4.52e-03	33	55	2	1022
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	ATR FRYL WDFY3 CEP97 MED13 GTF3C3	1.33e-06	193	80	6	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	facs-Lung-nan-3m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RIMBP3 EXD1 GPAT2 GRAMD1C PLXNB3	1.04e-05	160	80	5	f2cdee5a9e3b0eb125d6be7b5d239eb04333ae41
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ADRA2B ATAD5 PIEZO1 INTS1 CEP97	1.07e-05	161	80	5	2fe77af3b41e6eacb707a64feea18f9991618173
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	DRD1 ADRA2B MYO3B GPAT2	1.14e-05	77	80	4	10969743351c49a1d6d8ae1ef93098e7786ca3fe
ToppCell	Control-B_cells-Plasma_cells\|Control / group, cell type (main and fine annotations)	KNTC1 AFF2 MYO1D USP48 FBXW7	1.60e-05	175	80	5	fb23858cfce71509cafbe0d9728e678012ff2962
ToppCell	Influenza-Influenza_Severe-Myeloid-Neutrophil\|Influenza_Severe / Disease, condition lineage and cell class	ADRA2B WDFY3 MBOAT2 CEP97 SORL1	2.14e-05	186	80	5	1dfcec9196d4db76fba3abc74e85885b1fb98b87
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	KNTC1 IL12RB2 TRPM7 FRYL LYST	2.43e-05	191	80	5	9454f642c3621370fa23640b631301346b300950
Computational	Neighborhood of CCNF	SMG1 AFF2 MARS1 FANCI FRYL	1.54e-05	78	44	5	MORF_CCNF
Drug	lipo-polysaccharide	MPZ LYST FBXW7	3.08e-06	9	77	3	CID011970143
Drug	thiacloprid	MARS1 LYST MED13 FBXW7	5.19e-06	34	77	4	CID000115224
Disease	blue cone monochromacy (implicated_via_orthology)	OPN1MW2 OPN1MW3 OPN1MW	5.80e-08	4	73	3	DOID:0050679 (implicated_via_orthology)
Disease	Infiltrating duct carcinoma of female breast	SMG1 ATR TRPM7	1.87e-05	21	73	3	C3165106
Disease	Chediak-Higashi syndrome (implicated_via_orthology)	WDFY3 LYST	3.61e-05	4	73	2	DOID:2935 (implicated_via_orthology)
Disease	Spastic Paraplegia	LYST WDR48	2.15e-04	9	73	2	C0037772
Disease	Mental deterioration	CACNA1C SORL1	2.15e-04	9	73	2	C0234985
Disease	Mild cognitive disorder	CACNA1C SORL1	2.15e-04	9	73	2	C1270972
Disease	monocyte percentage of leukocytes	ADRA2B AFF2 P2RY2 PIEZO1 PHLPP1 WDFY3 GPAT2 S1PR4	4.44e-04	731	73	8	EFO_0007989
Disease	Impaired cognition	CACNA1C SORL1	5.39e-04	14	73	2	C0338656
Disease	revision of total joint arthroplasty, aseptic loosening	PHLPP1 CRPPA	7.08e-04	16	73	2	EFO_0010725, EFO_0020974
Disease	Charcot-Marie-Tooth disease type 2	MPZ MARS1	8.02e-04	17	73	2	cv:C0270914
Disease	Amphetamine-Related Disorders	DRD1 PROKR2 USP48	8.63e-04	75	73	3	C0236733
Disease	Amphetamine Abuse	DRD1 PROKR2 USP48	8.63e-04	75	73	3	C0236807
Disease	Amphetamine Addiction	DRD1 PROKR2 USP48	8.63e-04	75	73	3	C0236804
Disease	Malignant neoplasm of endometrium	ATR FBXW7	9.00e-04	18	73	2	C0007103
Disease	Carcinoma in situ of endometrium	ATR FBXW7	9.00e-04	18	73	2	C0346191
Disease	glucose homeostasis measurement, acute insulin response measurement	P2RY2 MTNR1B	9.00e-04	18	73	2	EFO_0006831, EFO_0006896
Disease	juvenile dermatomyositis	ADRA2B GPAT2	1.11e-03	20	73	2	EFO_0000557
Disease	hyperglycemia (biomarker_via_orthology)	DRD1 HCRTR2	1.23e-03	21	73	2	DOID:4195 (biomarker_via_orthology)
Disease	Ovarian Serous Adenocarcinoma	MYO3A TRPM7	1.48e-03	23	73	2	C1335177
Disease	urinary uromodulin measurement	TAF1B CRPPA GRAMD1C	1.76e-03	96	73	3	EFO_0005663
Disease	glucose tolerance test	MTNR1B PEX11A	2.04e-03	27	73	2	EFO_0004307
Disease	platelet crit	CACNA1C RETREG2 P2RY2 PIEZO1 PHLPP1 EIF3A S1PR4 SORL1	2.40e-03	952	73	8	EFO_0007985

Protein segments in the cluster

Peptide	Gene	Start	Entry
CDIRKSILYLQFWIR	ATAD5	1391	Q96QE3
ILLQGRLYLSENWLC	GRAMD1C	96	Q8IYS0
TNLVRYVRQGLCWLR	AFF2	1291	P51816
RRTWCEVYLALDVLF	ADRA2B	81	P18089
ILNLCVISVDRYWAI	DRD1	111	P21728
AELYCRAWRQALPQL	CAMSAP3	81	Q9P1Y5
VLCYLQVWLAIRAVA	OPN1MW3	236	P0DN78
AKALWVLARRCYTLQ	RIMBP3B	381	A6NNM3
AKALWVLARRCYTLQ	RIMBP3C	381	A6NJZ7
LISYTLQALERVCWI	CRPPA	76	A4D126
VLCYLQVWLAIRAVA	OPN1MW2	236	P0DN77
FQNLCDITRVLLWRY	FANCI	871	Q9NVI1
CQLFALLAAIWFRTY	MBOAT2	31	Q6ZWT7
LWDCLLSFIRLLLNY	INTS1	1931	Q8N201
CRLAYRADLEGLQVW	ASPG	506	Q86U10
LCWLQVATNCRVYLF	EXD1	116	Q8NHP7
RCTLYWRDEGLVLLN	IL12RB2	241	Q99665
VSFCYLRIWVLVLQA	MTNR1B	216	P49286
NWLSICLYAFLREVA	PLXNB3	1456	Q9ULL4
CNDIRINIWYGFSIL	OR52B4	191	Q8NGK2
RLLWVYVIRIKCESN	FRYL	361	O94915
ILCALIVFWKYRRFQ	CT83	11	Q5H943
SALKFCLYLAERWLQ	KNTC1	1706	P50748
RNYVDCVRWLGDLIL	EED	306	O75530
ESRICFLEGIWSNLY	PLA2G4B	491	P0C869
NLYFQRCLDWNRDIL	PADI2	541	Q9Y2J8
NAVALYIFLCRLKTW	P2RY2	51	P41231
RLYFIWVCRDIQSFR	NOX4	456	Q9NPH5
VLCYLQVWLAIRAVA	OPN1MW	236	P04001
LLRCRKEFYQLVWSA	POP5	66	Q969H6
LAYLQIFRKLWCRQI	HCRTR2	241	O43614
FFRRQELLLWQIGCV	ATR	221	Q13535
TGWYNRLFINFVLRR	GABRR3	251	A8MPY1
CVRLLRIFKITRYWN	CACNA1C	621	Q13936
KFLWESYRQCLDLLR	EIF3A	151	Q14152
WCLNLRVLDGYVISQ	CEP97	226	Q8IW35
VFWIHRLIKFIYNIC	ATG9A	141	Q7Z3C6
LGFEILCRYQNIWNI	GSTK1	21	Q9Y2Q3
LLQAAQTCRYWRILA	FBXW7	301	Q969H0
VRLFSWALLRFLNCL	GPAT2	161	Q6NUI2
CVLNLYYERRWEQSL	COQ4	231	Q9Y3A0
LLRSVCNLFSYWDIQ	ATG9B	296	Q674R7
VWQFLELFNSGRCLR	DEF6	181	Q9H4E7
IIWDLNRLCYVQSLA	LYST	3641	Q99698
RWRYCQVLNAIYIIQ	IQCF2	116	Q8IXL9
RSRRWVYYCLVNITL	S1PR4	76	O95977
LCTWIYQRQRRGSLF	SLC8B1	246	Q6J4K2
LDLLVWLRYFNSTCN	TAAR3P	291	Q9P1P4
FLCLLYSQRWKRTQR	RMDN3	26	Q96TC7
CLYWSDLALDVIQRL	SORL1	801	Q92673
WYRALLLETFRPQRC	TDRD6	326	O60522
WFGIRRDFCQFLLEI	TMEM185B	271	Q9H7F4
CLSLQYLTVDRNRLW	LRRC28	156	Q86X40
AKALWVLARRCYTLQ	RIMBP3	381	Q9UFD9
AFCYLSLLWQREAIT	TAF1B	216	Q53T94
NWLERLFYSCQRLDK	SMG1	881	Q96Q15
LYLLRLALFNPDVCW	NDUFA4	31	O00483
ELCRYLAESWLTFQI	RETREG2	156	Q8NC44
YLVLLANRLWCSKAR	SMIM24	46	O75264
LNRVIYFICDTILWV	PEX11A	91	O75192
VWENGLSYECRTLLF	MED13	106	Q9UHV7
RFVLEQYNALSWLTC	MED13	2131	Q9UHV7
VLYACERIIRFWRFQ	NOX3	276	Q9HBY0
ALVCSERYNLAVVWL	GTF3C3	446	Q9Y5Q9
LLRTYLWRCQFLLPF	CLDND1	131	Q9NY35
WSFFIYLLRRQIRTV	CTDNEP1	21	O95476
LWSLGQQRCIATYRV	WDR48	236	Q8TAF3
IWQGYNFLCDLLLRL	WDFY3	306	Q8IZQ1
FLLRVRCWQYRQLSA	RPL15	21	P61313
CCIIRVSTWNRLNYL	FAM20B	331	O75063
LCYARISRELWFKAV	PROKR2	241	Q8NFJ6
ICFDTFTEYLRWLRQ	PHLPP1	616	O60346
RQAIARLWPNYCLFL	PIEZO1	1031	Q92508
RLVLWDCLILYNVTV	PIEZO1	1211	Q92508
IWDSVCFFFLLLQRR	PIEZO1	1286	Q92508
VWFLNLELRQALYLC	USP48	106	Q86UV5
RYSRLRQWNTLYLCG	MARS1	296	P56192
CLNIIFWYVRLLDFL	TRPM7	966	Q96QT4
WLNNCVGERNYRLFL	ZDHHC1	166	Q8WTX9
LYRCVQELRQGLLVW	XKR8	96	Q9H6D3
AIYERLFCWIVTRIN	MYO1D	346	O94832
TLYGRLFSWIVNCIN	MYO3A	681	Q8NEV4
ALYGRLFSWIVNRIN	MYO3B	686	Q8WXR4
FYVVRYCWLRRQAAL	MPZ	176	P25189