Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3K4me/H3K4me2/H3K4me3 demethylase activity	KDM5C KDM5D	1.41e-04	6	62	2	GO:0034647
GeneOntologyMolecularFunction	histone H3K4 demethylase activity	KDM5C KDM5D	2.62e-04	8	62	2	GO:0032453
GeneOntologyMolecularFunction	demethylase activity	ALKBH1 KDM5C KDM5D	3.45e-04	44	62	3	GO:0032451
MousePheno	liver hypoplasia	TCEA1 ERN1 TSC1 TP53	6.93e-05	62	50	4	MP:0000600
MousePheno	increased leiomyosarcoma incidence	TSC1 TP53	7.49e-05	4	50	2	MP:0002035
MousePheno	prenatal lethality prior to heart atrial septation, incomplete penetrance	JUP LONP1 INTS15 MCL1 HUWE1 MAP2K1 TP53 ALPI	9.32e-05	410	50	8	MP:0031660
MousePheno	embryonic lethality, incomplete penetrance	JUP LONP1 INTS15 MCL1 HUWE1 MAP2K1 TP53 ALPI	9.32e-05	410	50	8	MP:0011102
MousePheno	abnormal vascular endothelial cell development	OTULIN MAPK7 MAP2K1	1.80e-04	31	50	3	MP:0003542
MousePheno	lens dislocation	ALKBH1 INTS15	1.86e-04	6	50	2	MP:0031428
MousePheno	increased hemangioma incidence	INTS15 TSC1 TP53	1.99e-04	32	50	3	MP:0002947
MousePheno	small placenta	ALKBH1 JUP ERN1 MAP2K1	2.06e-04	82	50	4	MP:0004259
MousePheno	abnormal embryo development	JUP LONP1 ERN1 PUF60 KDM5C NUP98 MCL1 TSC1 CHD8 HUWE1 MAPK7 IPO4 ALPI TGS1	2.24e-04	1370	50	14	MP:0001672
MousePheno	embryonic lethality before implantation, incomplete penetrance	INTS15 MCL1 ALPI	2.38e-04	34	50	3	MP:0011104
MousePheno	embryonic lethality prior to tooth bud stage, incomplete penetrance	LONP1 INTS15 MCL1 ALPI	3.93e-04	97	50	4	MP:0014258
MousePheno	embryonic lethality prior to organogenesis, incomplete penetrance	LONP1 INTS15 MCL1 ALPI	3.93e-04	97	50	4	MP:0014260
MousePheno	increased muscle tumor incidence	TSC1 TP53	4.44e-04	9	50	2	MP:0010290
MousePheno	abnormal prenatal body size	TCEA1 ALKBH1 JUP LONP1 ERN1 NUP98 TSC1 HUWE1 MAPK7 IPO4 MAP2K1 TGS1	4.44e-04	1116	50	12	MP:0010866
MousePheno	abnormal embryo size	TCEA1 JUP LONP1 ERN1 NUP98 TSC1 HUWE1 MAPK7 IPO4 MAP2K1 TGS1	4.56e-04	956	50	11	MP:0001697
MousePheno	abnormal embryonic growth/weight/body size	TCEA1 JUP LONP1 ERN1 NUP98 MCL1 TSC1 HUWE1 MAPK7 IPO4 MAP2K1 ALPI TGS1	4.74e-04	1295	50	13	MP:0002088
MousePheno	decreased embryo size	TCEA1 LONP1 ERN1 NUP98 TSC1 HUWE1 MAPK7 MAP2K1 TGS1	4.80e-04	659	50	9	MP:0001698
MousePheno	abnormal prenatal growth/weight/body size	TCEA1 ALKBH1 JUP LONP1 ERN1 NUP98 MCL1 TSC1 HUWE1 MAPK7 IPO4 MAP2K1 ALPI TGS1	5.45e-04	1493	50	14	MP:0004196
Domain	Lys_sp_deMease-like_dom	KDM5C KDM5D	6.27e-05	4	61	2	IPR013637
Domain	PLU-1	KDM5C KDM5D	6.27e-05	4	61	2	PF08429
Domain	zf-C5HC2	KDM5C KDM5D	1.04e-04	5	61	2	PF02928
Domain	Znf_C5HC2	KDM5C KDM5D	1.04e-04	5	61	2	IPR004198
Domain	JmjN	KDM5C KDM5D	4.64e-04	10	61	2	SM00545
Domain	JMJN	KDM5C KDM5D	4.64e-04	10	61	2	PS51183
Domain	JmjN	KDM5C KDM5D	4.64e-04	10	61	2	PF02375
Domain	JmjN	KDM5C KDM5D	4.64e-04	10	61	2	IPR003349
Domain	-	KDM5C KDM5D	1.07e-03	15	61	2	1.10.150.60
Domain	BRIGHT	KDM5C KDM5D	1.07e-03	15	61	2	SM00501
Domain	ARID_dom	KDM5C KDM5D	1.07e-03	15	61	2	IPR001606
Domain	ARID	KDM5C KDM5D	1.07e-03	15	61	2	PS51011
Domain	ARID	KDM5C KDM5D	1.07e-03	15	61	2	PF01388
Domain	JmjC	KDM5C KDM5D	2.77e-03	24	61	2	PF02373
Domain	JMJC	KDM5C KDM5D	4.89e-03	32	61	2	PS51184
Domain	JmjC_dom	KDM5C KDM5D	4.89e-03	32	61	2	IPR003347
Domain	JmjC	KDM5C KDM5D	5.19e-03	33	61	2	SM00558
Domain	DNA/RNA_helicase_DEAH_CS	DHX16 CHD8	5.83e-03	35	61	2	IPR002464
Pubmed	The double life of MULE in preeclamptic and IUGR placentae.	MCL1 HUWE1 TP53	5.94e-09	3	64	3	22552282
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	DHX16 JUP NUP98 TNKS1BP1 PRKCSH SF3B2 GOLGB1 MAP3K2 AHNAK2	2.06e-08	360	64	9	33111431
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	JUP MAP7D3 GTSE1 NUP98 TNKS1BP1 SF3B2 GOLGB1 AHNAK2	2.40e-08	256	64	8	33397691
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	DHX16 LONP1 RRP1B PUF60 NUP98 CHD8 TNKS1BP1 HUWE1 IPO4 SF3B2 TP53	2.84e-08	653	64	11	22586326
Pubmed	Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.	TRERF1 MAP2 GTSE1 GGA1 TP53 MAP3K2	5.63e-08	110	64	6	37219487
Pubmed	Platelet-derived growth factor (PDGF)-induced activation of Erk5 MAP-kinase is dependent on Mekk2, Mek1/2, PKC and PI3-kinase, and affects BMP signaling.	MAPK7 MAP2K1 MAP3K2	1.18e-07	6	64	3	27339033
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	DHX16 TRERF1 TCEA1 UBE4B KDM5C GTSE1 NUP98 TNKS1BP1 HUWE1 SF3B2 ALPI	1.57e-07	774	64	11	15302935
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	DHX16 JUP LONP1 RRP1B PUF60 GTSE1 NUP98 PRKCSH HUWE1 SF3B2 GOLGB1 TP53	3.19e-07	1024	64	12	24711643
Pubmed	mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition.	MCL1 TSC1 TP53	4.95e-07	9	64	3	19620286
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	TCEA1 MAP7D3 RRP1B NUP98 TSC1 CHD8 KDM5D TP53	8.82e-07	411	64	8	35182466
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	KDM5C GTSE1 MCL1 CHD8 TNKS1BP1 HUWE1 AHNAK2	2.64e-06	332	64	7	37433992
Pubmed	A human MAP kinase interactome.	JUP USF3 NUP98 CHD8 MAPK7 MAP2K1 GOLGB1 MAP3K2	3.06e-06	486	64	8	20936779
Pubmed	Mitochondrial Lon sequesters and stabilizes p53 in the matrix to restrain apoptosis under oxidative stress via its chaperone activity.	LONP1 TP53	3.33e-06	2	64	2	29899330
Pubmed	Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice.	KDM5C KDM5D	3.33e-06	2	64	2	32081420
Pubmed	A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.	KDM5C KDM5D	3.33e-06	2	64	2	7524912
Pubmed	Tobramycin suppresses HUWE1 degradation to control MCL-1 stability during tumour development.	MCL1 HUWE1	3.33e-06	2	64	2	32378766
Pubmed	The Codon 72 TP53 Polymorphism Contributes to TSC Tumorigenesis through the Notch-Nodal Axis.	TSC1 TP53	3.33e-06	2	64	2	31088907
Pubmed	X-Linked Huwe1 Is Essential for Oocyte Maturation and Preimplantation Embryo Development.	HUWE1 TP53	3.33e-06	2	64	2	32927266
Pubmed	The Pro/Pro genotype of the p53 codon 72 polymorphism modulates PAI-1 plasma levels in ageing.	SERPINE1 TP53	3.33e-06	2	64	2	19523975
Pubmed	Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven.	KDM5C KDM5D	3.33e-06	2	64	2	9060413
Pubmed	HUWE1 controls the development of non-small cell lung cancer through down-regulation of p53.	HUWE1 TP53	3.33e-06	2	64	2	30026863
Pubmed	GTSE1 is involved in breast cancer progression in p53 mutation-dependent manner.	GTSE1 TP53	3.33e-06	2	64	2	30961661
Pubmed	Mcl-1 as a potential therapeutic target for human hepatocelluar carcinoma.	MCL1 TP53	3.33e-06	2	64	2	27465322
Pubmed	hGTSE-1 expression stimulates cytoplasmic localization of p53.	GTSE1 TP53	3.33e-06	2	64	2	14707141
Pubmed	PAI-1 Regulation of p53 Expression and Senescence in Type II Alveolar Epithelial Cells.	SERPINE1 TP53	3.33e-06	2	64	2	37566086
Pubmed	The cell cycle-regulated protein human GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function.	GTSE1 TP53	3.33e-06	2	64	2	12750368
Pubmed	Mouse H-Y encoding Smcy gene and its X chromosomal homolog Smcx.	KDM5C KDM5D	3.33e-06	2	64	2	10441747
Pubmed	Inefficient purifying selection: the mammalian Y chromosome in the rodent genus Mus.	KDM5C KDM5D	3.33e-06	2	64	2	16416087
Pubmed	p53-dependent repression of the human MCL-1 gene encoding an anti-apoptotic member of the BCL-2 family: the role of Sp1 and of basic transcription factor binding sites in the MCL-1 promoter.	MCL1 TP53	3.33e-06	2	64	2	18208354
Pubmed	Nucleoporin Nup98 is an essential factor for ipo4 dependent protein import.	NUP98 IPO4	3.33e-06	2	64	2	38780165
Pubmed	Tumour suppressive function of HUWE1 in thyroid cancer.	HUWE1 TP53	3.33e-06	2	64	2	27581931
Pubmed	Autism-associated chromatin remodeler CHD8 regulates erythroblast cytokinesis and fine-tunes the balance of Rho GTPase signaling.	CHD8 TP53	3.33e-06	2	64	2	35830790
Pubmed	Regulation of airway and alveolar epithelial cell apoptosis by p53-Induced plasminogen activator inhibitor-1 during cigarette smoke exposure injury.	SERPINE1 TP53	3.33e-06	2	64	2	22592924
Pubmed	Regulation of plasminogen activator inhibitor-1 expression by tumor suppressor protein p53.	SERPINE1 TP53	3.33e-06	2	64	2	18469003
Pubmed	The physical interaction of p53 and plakoglobin is necessary for their synergistic inhibition of migration and invasion.	JUP TP53	3.33e-06	2	64	2	27058623
Pubmed	Tsc1-Tp53 loss induces mesothelioma in mice, and evidence for this mechanism in human mesothelioma.	TSC1 TP53	3.33e-06	2	64	2	23851502
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	DHX16 MAP7D3 PUF60 KDM5C GTSE1 FRMPD1 NUP98 HUWE1 SF3B2 TP53	3.56e-06	857	64	10	25609649
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	JUP MAP7D3 MAP2 GTSE1 TNKS1BP1 MAP2K1 GOLGB1 TP53 MAP3K2 AHNAK2	3.71e-06	861	64	10	36931259
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	RRP1B KDM5C GTSE1 NUP98 CHD8 TNKS1BP1 HUWE1 IPO4	3.94e-06	503	64	8	16964243
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	JUP MAP7D3 PUF60 NUP98 TSC1 TNKS1BP1 SF3B2 GOLGB1 TP53 AHNAK2	7.58e-06	934	64	10	33916271
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	TCEA1 JUP MAP7D3 RRP1B PUF60 GTSE1 NUP98 CHD8 SF3B2 TP53	9.11e-06	954	64	10	36373674
Pubmed	Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.	KDM5C TSC1 MAP2K1 TP53	9.23e-06	71	64	4	28319113
Pubmed	MEF2C regulates c-Jun but not TNF-alpha gene expression in stimulated mast cells.	MAPK7 MAP3K2	9.99e-06	3	64	2	14515274
Pubmed	Focused PCR screen reveals p53 dependence of nitric oxide-induced apoptosis and up-regulation of maspin and plasminogen activator inhibitor-1 in tumor cells.	SERPINE1 TP53	9.99e-06	3	64	2	19147537
Pubmed	Regulation of lung injury and fibrosis by p53-mediated changes in urokinase and plasminogen activator inhibitor-1.	SERPINE1 TP53	9.99e-06	3	64	2	23665346
Pubmed	Clinical significance and expression of PUMA, MCL-1, and p53 in human renal cell carcinoma and para-carcinoma tissues.	MCL1 TP53	9.99e-06	3	64	2	28692117
Pubmed	SGK1 inhibits cellular apoptosis and promotes proliferation via the MEK/ERK/p53 pathway in colitis.	MAP2K1 TP53	9.99e-06	3	64	2	26034353
Pubmed	Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis.	MCL1 HUWE1	9.99e-06	3	64	2	15989957
Pubmed	A structural element within the HUWE1 HECT domain modulates self-ubiquitination and substrate ubiquitination activities.	MCL1 HUWE1	9.99e-06	3	64	2	20007713
Pubmed	Ursolic acid facilitates apoptosis in rheumatoid arthritis synovial fibroblasts by inducing SP1-mediated Noxa expression and proteasomal degradation of Mcl-1.	MCL1 HUWE1	9.99e-06	3	64	2	29799788
Pubmed	Loss of p53 enhances the function of the endoplasmic reticulum through activation of the IRE1α/XBP1 pathway.	ERN1 TP53	9.99e-06	3	64	2	26254280
Pubmed	Plakoglobin interacts with the transcription factor p53 and regulates the expression of 14-3-3σ.	JUP TP53	9.99e-06	3	64	2	23687381
Pubmed	Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery.	GTSE1 TP53	9.99e-06	3	64	2	20577264
Pubmed	Integrin alphav-mediated inactivation of p53 controls a MEK1-dependent melanoma cell survival pathway in three-dimensional collagen.	MAP2K1 TP53	9.99e-06	3	64	2	15557124
Pubmed	Identification of a mouse male-specific transplantation antigen, H-Y.	KDM5C KDM5D	9.99e-06	3	64	2	7544442
Pubmed	MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation.	MAPK7 MAP3K2	9.99e-06	3	64	2	15075238
Pubmed	Direct regulation of Chk1 protein stability by E3 ubiquitin ligase HUWE1.	HUWE1 TP53	9.99e-06	3	64	2	31713291
Pubmed	Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1.	PUF60 TP53	9.99e-06	3	64	2	25671302
Pubmed	LIMCH1 suppress the growth of lung cancer by interacting with HUWE1 to sustain p53 stability.	HUWE1 TP53	9.99e-06	3	64	2	31279706
Pubmed	BH3 mimetics selectively eliminate chemotherapy-induced senescent cells and improve response in TP53 wild-type breast cancer.	MCL1 TP53	9.99e-06	3	64	2	32457483
Pubmed	Plakoglobin restores tumor suppressor activity of p53R175H mutant by sequestering the oncogenic potential of β-catenin.	JUP TP53	9.99e-06	3	64	2	29660231
Pubmed	HUWE1 controls MCL1 stability to unleash AMBRA1-induced mitophagy.	MCL1 HUWE1	9.99e-06	3	64	2	31434979
Pubmed	A conformational switch regulates the ubiquitin ligase HUWE1.	MCL1 HUWE1	9.99e-06	3	64	2	28193319
Pubmed	Metformin enhances TRAIL-induced apoptosis by Mcl-1 degradation via Mule in colorectal cancer cells.	MCL1 HUWE1	9.99e-06	3	64	2	27517746
Pubmed	Cofilin-mediated Neuronal Apoptosis via p53 Translocation and PLD1 Regulation.	PLD1 TP53	9.99e-06	3	64	2	28912445
Pubmed	A comparison among HER2, TP53, PAI-1, angiogenesis, and proliferation activity as prognostic variables in tumours from 408 patients diagnosed with early breast cancer.	SERPINE1 TP53	9.99e-06	3	64	2	18465330
Pubmed	Anti-apoptosis proteins Mcl-1 and Bcl-xL have different p53-binding profiles.	MCL1 TP53	9.99e-06	3	64	2	23977882
Pubmed	Essential role of plasminogen activator inhibitor type-1 in radiation enteropathy.	SERPINE1 TP53	9.99e-06	3	64	2	18276785
Pubmed	TGF-β induces p53/Smads complex formation in the PAI-1 promoter to activate transcription.	SERPINE1 TP53	9.99e-06	3	64	2	27759037
Pubmed	MEK1,2 response element mediates angiotensin II-stimulated plasminogen activator inhibitor-1 promoter activation.	SERPINE1 MAP2K1	9.99e-06	3	64	2	14656894
Pubmed	Regulation of p53 level by UBE4B in breast cancer.	UBE4B TP53	9.99e-06	3	64	2	24587254
Pubmed	ERK5 protein promotes, whereas MEK1 protein differentially regulates, the Toll-like receptor 2 protein-dependent activation of human endothelial cells and monocytes.	MAPK7 MAP2K1	9.99e-06	3	64	2	22707717
Pubmed	MicroRNA-1301 suppresses tumor cell migration and invasion by targeting the p53/UBE4B pathway in multiple human cancer cells.	UBE4B TP53	9.99e-06	3	64	2	28483517
Pubmed	NOTCH1, TP53, and MAP2K1 Mutations in Splenic Diffuse Red Pulp Small B-cell Lymphoma Are Associated With Progressive Disease.	MAP2K1 TP53	9.99e-06	3	64	2	26426381
Pubmed	P53 tumor suppressor factor, plasminogen activator inhibitor, and vascular endothelial growth factor gene polymorphisms and recurrent implantation failure.	SERPINE1 TP53	9.99e-06	3	64	2	18829023
Pubmed	Synergistic induction of profibrotic PAI-1 by TGF-β and radiation depends on p53.	SERPINE1 TP53	9.99e-06	3	64	2	20435362
Pubmed	Overexpression of G2 and S phase-expressed-1 contributes to cell proliferation, migration, and invasion via regulating p53/FoxM1/CCNB1 pathway and predicts poor prognosis in bladder cancer.	GTSE1 TP53	9.99e-06	3	64	2	30414902
Pubmed	The chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability.	CHD8 TP53	9.99e-06	3	64	2	34292326
Pubmed	ERK5 regulates basic fibroblast growth factor-induced type 1 plasminogen activator inhibitor expression and cell proliferation in lung fibroblasts.	SERPINE1 MAPK7	9.99e-06	3	64	2	26032256
Pubmed	Loss of p53 and altered miR15-a/16-1MCL-1 pathway in CLL: insights from TCL1-Tg:p53(-/-) mouse model and primary human leukemia cells.	MCL1 TP53	9.99e-06	3	64	2	23608884
Pubmed	MCL-1 but not BCL-XL is critical for the development and sustained expansion of thymic lymphoma in p53-deficient mice.	MCL1 TP53	9.99e-06	3	64	2	25368374
Pubmed	Reduced association of anti-apoptotic protein Mcl-1 with E3 ligase Mule increases the stability of Mcl-1 in breast cancer cells.	MCL1 HUWE1	9.99e-06	3	64	2	21730980
Pubmed	Plakoglobin Reduces the in vitro Growth, Migration and Invasion of Ovarian Cancer Cells Expressing N-Cadherin and Mutant p53.	JUP TP53	9.99e-06	3	64	2	27144941
Pubmed	USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1.	HUWE1 TP53	9.99e-06	3	64	2	21522127
Pubmed	Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kip1 expression in TSC2+/- cells.	TSC1 TP53	9.99e-06	3	64	2	12037687
Pubmed	Role of bile salt in regulating Mcl-1 phosphorylation and chemoresistance in hepatocellular carcinoma cells.	MCL1 HUWE1	9.99e-06	3	64	2	21507240
Pubmed	UBE4B targets phosphorylated p53 at serines 15 and 392 for degradation.	UBE4B TP53	9.99e-06	3	64	2	26673821
Pubmed	HOXD3 Up-regulating KDM5C Promotes Malignant Progression of Diffuse Large B-Cell Lymphoma by Decreasing p53 Expression.	KDM5C TP53	9.99e-06	3	64	2	34928233
Pubmed	Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes.	NUP98 TP53	9.99e-06	3	64	2	23102701
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	KDM5C MED25 TSC1 TNKS1BP1 HUWE1 IPO4 GOLGB1 TP53	1.23e-05	588	64	8	38580884
Pubmed	A bead-based approach for large-scale identification of in vitro kinase substrates.	DHX16 RRP1B NUP98 TNKS1BP1 SF3B2	1.30e-05	163	64	5	22113938
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	TRERF1 USF3 GTSE1 NUP98 KDM5D ZKSCAN5 TP53	1.42e-05	430	64	7	35044719
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	DHX16 JUP LONP1 RRP1B PUF60 TSC1 TNKS1BP1 SF3B2	1.43e-05	601	64	8	33658012
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	MAP7D3 TNKS1BP1 HUWE1 MAP2K1 GGA1 TP53	1.53e-05	288	64	6	23383273
Pubmed	SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.	JUP LONP1 PUF60 PRKCSH HUWE1 IPO4 MAP2K1 SF3B2	1.54e-05	607	64	8	39147351
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	DHX16 TCEA1 LONP1 PUF60 KDM5C NUP98 MED25 CHD8 SF3B2 TP53	1.54e-05	1014	64	10	32416067
Pubmed	Noncanonical function of MEKK2 and MEK5 PB1 domains for coordinated extracellular signal-regulated kinase 5 and c-Jun N-terminal kinase signaling.	MAPK7 MAP3K2	2.00e-05	4	64	2	17452462
Pubmed	RITA enhances irradiation-induced apoptosis in p53-defective cervical cancer cells via upregulation of IRE1α/XBP1 signaling.	ERN1 TP53	2.00e-05	4	64	2	26134873
Pubmed	Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life.	HUWE1 TP53	2.00e-05	4	64	2	38453366
Pubmed	Mammalian target of rapamycin complex 1 and cyclooxygenase 2 pathways cooperatively exacerbate endometrial cancer.	TSC1 TP53	2.00e-05	4	64	2	25058027
Interaction	PHLPP1 interactions	JUP MAP7D3 GTSE1 NUP98 TSC1 TNKS1BP1 SF3B2 GOLGB1 AHNAK2	8.90e-07	333	63	9	int:PHLPP1
Interaction	AXIN1 interactions	JUP PUF60 TSC1 MAP2K1 TP53 MAP3K2	1.31e-05	166	63	6	int:AXIN1
Interaction	SIRT7 interactions	DHX16 LONP1 RRP1B PUF60 NUP98 CHD8 TNKS1BP1 HUWE1 IPO4 SF3B2 TP53	1.72e-05	744	63	11	int:SIRT7
Interaction	FBXW7 interactions	DHX16 JUP LONP1 RRP1B PUF60 MCL1 TSC1 TNKS1BP1 HUWE1 IPO4 MAP2K1 SF3B2 TP53 TGS1	1.80e-05	1215	63	14	int:FBXW7
Interaction	MEX3A interactions	KDM5C GTSE1 MCL1 CHD8 TNKS1BP1 HUWE1 TP53 AHNAK2	2.51e-05	384	63	8	int:MEX3A
Interaction	ARF1 interactions	SERPINE1 TSC1 PLD1 HUWE1 PTPN18 GGA1 GOLGB1	2.76e-05	282	63	7	int:ARF1
Interaction	UBE2O interactions	DHX16 TCEA1 JUP MAP7D3 RRP1B PUF60 PLD1 HUWE1 IPO4 SF3B2 TP53	2.99e-05	790	63	11	int:UBE2O
Interaction	TSC2 interactions	OTULIN CBY2 TSC1 PRKCSH HUWE1 TP53	3.36e-05	196	63	6	int:TSC2
Interaction	CDKN2A interactions	UBE4B AOPEP TSC1 HUWE1 MAP2K1 GGA1 TP53	8.20e-05	335	63	7	int:CDKN2A
Interaction	MAPK7 interactions	JUP MAPK7 GOLGB1 TP53 MAP3K2	8.47e-05	143	63	5	int:MAPK7
Interaction	ACTN1 interactions	JUP MAP2 CBY2 KDM5C PCP2 TSC1 GOLGB1	9.16e-05	341	63	7	int:ACTN1
Interaction	GLRA1 interactions	HUWE1 TP53	9.56e-05	5	63	2	int:GLRA1
Interaction	TBX5 interactions	TCEA1 MAP7D3 RRP1B NUP98 TP53	1.06e-04	150	63	5	int:TBX5
Interaction	CTSB interactions	CNPY3 HUWE1 IPO4 MAP2K1 PTPN18 TP53	1.08e-04	242	63	6	int:CTSB
Interaction	CIT interactions	DHX16 JUP LONP1 RRP1B MRPL47 PUF60 NUP98 CNPY3 MCL1 CHD8 TNKS1BP1 SF3B2 TP53 AHNAK2	1.24e-04	1450	63	14	int:CIT
Interaction	YAP1 interactions	TRERF1 JUP MAP7D3 RRP1B MAP2 CHD8 TNKS1BP1 HUWE1 MAP2K1 SF3B2 TP53 MAP3K2	1.27e-04	1095	63	12	int:YAP1
Interaction	CPVL interactions	SOX5 OTULIN TSC1 HUWE1 PTPN18	1.28e-04	156	63	5	int:CPVL
Interaction	ACE2 interactions	DHX16 TCEA1 JUP LONP1 RRP1B PUF60 GTSE1 NUP98 SF3B2 GOLGB1 TP53 AHNAK2	1.39e-04	1106	63	12	int:ACE2
GeneFamily	AT-rich interaction domain containing	KDM5C KDM5D	5.17e-04	15	41	2	418
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM5C KDM5D	1.34e-03	24	41	2	485
Coexpression	GSE8384_CTRL_VS_B_ABORTUS_4H_MAC_CELL_LINE_DN	CLCN5 PDE1B UBE4B SERPINE1 CHD8 KDM5D	7.89e-06	200	62	6	M5758
Drug	Serotonin hydrochloride [153-98-0]; Down 200; 18.8uM; PC3; HT_HG-U133A	KDM5C INTS15 MED25 MAPK7 PTPN18 GGA1 TGS1	1.07e-06	197	62	7	4673_DN
Drug	Terazosin hydrochloride [63590-64-7]; Down 200; 9.4uM; PC3; HT_HG-U133A	UBE4B KDM5C MED25 MCL1 MAPK7 PTPN18 RAB11FIP3	1.19e-06	200	62	7	5831_DN
Drug	deguelin	SOX5 ERN1 NUP98 MCL1 MAP2K1 TP53	1.98e-06	137	62	6	ctd:C107676
Drug	Melatonin	ERN1 PDE1B MAP2 MCL1 MAP2K1 TP53 ALPI	4.32e-06	243	62	7	ctd:D008550
Drug	AC1L96VB	UBE4B MCL1 TNKS1BP1 KDM5D MAP2K1 TP53	1.34e-05	191	62	6	CID000439200
Drug	deferoxamine mesylate salt; Down 200; 100uM; MCF7; HG-U133A	RRP1B UBE4B AOPEP GTSE1 INTS15 PTPN18	1.51e-05	195	62	6	573_DN
Drug	Estriol [50-27-1]; Up 200; 13.8uM; PC3; HT_HG-U133A	MAP7D3 FRMPD1 HUWE1 MAPK7 PTPN18 DNAH9	1.60e-05	197	62	6	5866_UP
Drug	Clozapine [5786-21-0]; Down 200; 12.2uM; MCF7; HT_HG-U133A	CLCN5 INTS15 NUP98 MED25 MCL1 TGS1	1.60e-05	197	62	6	2644_DN
Drug	(+)-Isoproterenol (+)-bitartrate salt [14638-70-1]; Down 200; 11uM; PC3; HT_HG-U133A	UBE4B SERPINE1 PLD1 MAPK7 PTPN18 RAB11FIP3	1.60e-05	197	62	6	6663_DN
Drug	Bemegride [64-65-3]; Down 200; 25.8uM; PC3; HT_HG-U133A	UBE4B PLD1 MAPK7 PTPN18 GGA1 RAB11FIP3	1.64e-05	198	62	6	6668_DN
Drug	Sulfisoxazole [127-69-5]; Down 200; 15uM; PC3; HT_HG-U133A	CLCN5 UBE4B FRMPD1 PLD1 PTPN18 TGS1	1.64e-05	198	62	6	4661_DN
Drug	Tomatidine [77-59-8]; Down 200; 9.6uM; PC3; HT_HG-U133A	CLCN5 RRP1B DIP2C CNPY3 MAPK7 PTPN18	1.69e-05	199	62	6	5808_DN
Drug	PF-01378883-00 [351320-41-7]; Down 200; 10uM; PC3; HT_HG-U133A	MCL1 MAPK7 PTPN18 GGA1 MAP3K2 RAB11FIP3	1.69e-05	199	62	6	6410_DN
Drug	NSC339555	LONP1 MCL1 PLD1 MAP2K1 TP53	3.12e-05	133	62	5	CID000433902
Drug	Maneb	PDE1B MAP2 PCP2 SERPINE1 MCL1 MAP2K1 TP53	4.08e-05	344	62	7	ctd:D008344
Drug	NSC226080	TRERF1 SERPINE1 MCL1 TSC1 PLD1 MAPK7 MAP2K1 GOLGB1 TP53 ALPI	4.60e-05	782	62	10	CID000005040
Drug	diphenylarsinic acid	LONP1 MCL1 MAP2K1	8.19e-05	31	62	3	ctd:C493087
Drug	EHNA	PDE1B GUCY1A2 DNAH9 TGS1	9.37e-05	87	62	4	CID000003206
Drug	scriptaid; Up 200; 10uM; PC3; HT_HG-U133A	MAP2 UBE4B SERPINE1 PLD1 MAP3K2	1.18e-04	176	62	5	6896_UP
Drug	retinoic acid; Down 200; 1uM; HL60; HT_HG-U133A	RRP1B INTS15 OSBPL1A PLD1 GOLGB1	1.31e-04	180	62	5	1152_DN
Drug	C2-ceramide	ERN1 SERPINE1 PLD1 MAPK7 MAP2K1 TP53	1.48e-04	294	62	6	CID000002505
Drug	nickel subsulfide	TCEA1 JUP SERPINE1 MCL1 TP53	1.61e-04	188	62	5	ctd:C017557
Drug	U0126	SERPINE1 MCL1 PLD1 MAPK7 MAP2K1 TP53 MAP3K2	1.64e-04	430	62	7	CID000005637
Drug	AC1NRA8N	MCL1 PLD1 GGA1 GOLGB1 RAB11FIP3	1.65e-04	189	62	5	CID005287758
Drug	orthovanadate	PDE1B PLD1 MAPK7 MAP2K1 DNAH9 TP53 ALPI	1.76e-04	435	62	7	CID000061672
Drug	17-AAG; Up 200; 1uM; MCF7; HT_HG-U133A	OSBPL1A MED25 MCL1 MAPK7 GGA1	1.82e-04	193	62	5	5914_UP
Drug	radicicol; Up 200; 0.1uM; HL60; HG-U133A	RRP1B UBE4B DIP2C ZKSCAN5 RAB11FIP3	1.82e-04	193	62	5	544_UP
Drug	methyl ethyl ketone	MAP2 SERPINE1 MCL1 PLD1 MAPK7 MAP2K1 TP53 MAP3K2	1.85e-04	587	62	8	CID000006569
Drug	Amikacin hydrate [37517-28-5]; Down 200; 6.6uM; PC3; HT_HG-U133A	RRP1B UBE4B KDM5C NUP98 RAB11FIP3	1.86e-04	194	62	5	6715_DN
Drug	Metaproterenol sulfate, orciprenaline sulfate [5874-97-5]; Down 200; 7.6uM; PC3; HT_HG-U133A	FRMPD1 SERPINE1 MED25 MAPK7 GGA1	1.86e-04	194	62	5	4248_DN
Drug	Hesperidin [520-26-3]; Up 200; 6.6uM; HL60; HT_HG-U133A	RRP1B SERPINE1 MED25 MCL1 MAP3K2	1.86e-04	194	62	5	1294_UP
Drug	Methyl benzethonium chloride [25155-18-4]; Down 200; 8.6uM; PC3; HT_HG-U133A	KDM5C SERPINE1 MAPK7 TGS1 RAB11FIP3	1.86e-04	194	62	5	4325_DN
Drug	vanadyl	PDE1B PLD1 MAPK7 MAP2K1 DNAH9 ALPI	1.87e-04	307	62	6	CID000061671
Drug	7-hydroxystaurosporine	MCL1 MAP2K1 TP53	1.90e-04	41	62	3	ctd:C054852
Drug	PI103	MCL1 MAP2K1 TP53	1.90e-04	41	62	3	ctd:C522973
Drug	vitamin D3 analog	MCL1 KDM5D TP53	1.90e-04	41	62	3	CID006438384
Drug	(R)-Propranolol hydrochloride [13071-11-9]; Down 200; 13.6uM; PC3; HT_HG-U133A	CLCN5 RRP1B KDM5C MAPK7 RAB11FIP3	1.91e-04	195	62	5	5814_DN
Drug	PHA-00851261E [724719-49-7]; Down 200; 1uM; PC3; HT_HG-U133A	MCL1 MAPK7 GGA1 TGS1 RAB11FIP3	1.91e-04	195	62	5	4333_DN
Drug	Quinacrine dihydrochloride dihydrate [6151-30-0]; Down 200; 7.8uM; MCF7; HT_HG-U133A	OSBPL1A NUP98 MED25 TSC1 MAPK7	1.91e-04	195	62	5	3179_DN
Drug	Droperidol [548-73-2]; Down 200; 10.6uM; HL60; HT_HG-U133A	JUP MAP7D3 INTS15 PRKCSH GGA1	1.91e-04	195	62	5	1290_DN
Drug	Betulinic acid [472-15-1]; Up 200; 8.8uM; HL60; HT_HG-U133A	GTSE1 INTS15 PLD1 IPO4 RAB11FIP3	1.91e-04	195	62	5	1345_UP
Drug	Ethisterone [434-03-7]; Down 200; 12.8uM; MCF7; HT_HG-U133A	MAP7D3 MCL1 MAP3K2 AHNAK2 TGS1	1.91e-04	195	62	5	3864_DN
Drug	Dipyridamole [58-32-2]; Down 200; 8uM; PC3; HT_HG-U133A	RRP1B FRMPD1 SERPINE1 MAPK7 TGS1	1.95e-04	196	62	5	4656_DN
Drug	Prostaglandin E1; Down 200; 10uM; PC3; HT_HG-U133A	MED25 CNPY3 PTPN18 GGA1 RAB11FIP3	1.95e-04	196	62	5	6571_DN
Drug	Dropropizine (R,S) [17692-31-8]; Down 200; 17uM; MCF7; HT_HG-U133A	MAP7D3 INTS15 OSBPL1A GGA1 ZKSCAN5	1.95e-04	196	62	5	7429_DN
Drug	Methazolamide [554-57-4]; Down 200; 17uM; HL60; HT_HG-U133A	CLCN5 RRP1B UBE4B AOPEP MCL1	1.95e-04	196	62	5	2733_DN
Drug	Flucloxacillin sodium [1847-24-1]; Down 200; 8.4uM; MCF7; HT_HG-U133A	CLCN5 UBE4B KDM5C MAPK7 MAP3K2	2.00e-04	197	62	5	6507_DN
Drug	Guanadrel sulfate [22195-34-2]; Down 200; 7.6uM; PC3; HT_HG-U133A	RRP1B UBE4B PTPN18 GGA1 RAB11FIP3	2.00e-04	197	62	5	7396_DN
Drug	Acenocoumarol [152-72-7]; Down 200; 11.4uM; HL60; HG-U133A	MAP7D3 INTS15 NUP98 PLD1 PTPN18	2.00e-04	197	62	5	1394_DN
Drug	Probucol [23288-49-5]; Down 200; 7.8uM; PC3; HT_HG-U133A	MED25 MAPK7 PTPN18 GGA1 MAP3K2	2.00e-04	197	62	5	4666_DN
Drug	Flupentixol dihydrochloride cis-(Z) [2413-38-9]; Down 200; 7.8uM; MCF7; HT_HG-U133A	MAP7D3 UBE4B NUP98 MED25 TGS1	2.00e-04	197	62	5	2643_DN
Drug	aspirin, USP; Down 200; 100uM; HL60; HT_HG-U133A	RRP1B UBE4B INTS15 PRKCSH PTPN18	2.00e-04	197	62	5	1145_DN
Drug	THIP Hydrochloride; Down 200; 22.6uM; HL60; HT_HG-U133A	INTS15 SERPINE1 PLD1 GGA1 RAB11FIP3	2.00e-04	197	62	5	3132_DN
Drug	C75; Down 200; 10uM; PC3; HT_HG-U133A	PLD1 MAPK7 GGA1 ZKSCAN5 RAB11FIP3	2.00e-04	197	62	5	6428_DN
Drug	thioridazine hydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A	SERPINE1 MED25 MCL1 PLD1 MAPK7	2.00e-04	197	62	5	5916_UP
Drug	Trimeprazine tartrate [4330-99-8]; Down 200; 5.4uM; MCF7; HT_HG-U133A	RRP1B MAB21L4 KDM5C GTSE1 PTPN18	2.00e-04	197	62	5	3478_DN
Drug	FTI-277	SERPINE1 MCL1 MAP2K1 TP53	2.01e-04	106	62	4	CID003005531
Drug	3,4,5,4'-tetrahydroxystilbene	MCL1 TP53	2.02e-04	8	62	2	ctd:C422863
Drug	Cortisone [53-06-5]; Down 200; 11uM; MCF7; HT_HG-U133A	UBE4B KDM5C CNPY3 PTPN18 TGS1	2.05e-04	198	62	5	7416_DN
Drug	Ketoprofen [22071-15-4]; Up 200; 15.8uM; PC3; HT_HG-U133A	MAP7D3 FRMPD1 MED25 PLD1 GGA1	2.05e-04	198	62	5	4286_UP
Drug	Dimethisoquin hydrochloride [2773-92-4]; Down 200; 13uM; MCF7; HT_HG-U133A	CLCN5 NUP98 GGA1 ZKSCAN5 TGS1	2.05e-04	198	62	5	4791_DN
Drug	Streptomycin sulfate [3810-74-0]; Down 200; 2.8uM; PC3; HT_HG-U133A	UBE4B MED25 MCL1 GGA1 MAP3K2	2.05e-04	198	62	5	5837_DN
Drug	Pyridoxine hydrochloride [58-56-0]; Down 200; 19.4uM; PC3; HT_HG-U133A	CLCN5 MCL1 MAP3K2 TGS1 RAB11FIP3	2.05e-04	198	62	5	5813_DN
Drug	Convolamine hydrochloride [500-56-1]; Down 200; 11.8uM; MCF7; HT_HG-U133A	MAB21L4 KDM5C MAPK7 ZKSCAN5 MAP3K2	2.05e-04	198	62	5	2771_DN
Drug	Amitryptiline hydrochloride [549-18-8]; Down 200; 12.8uM; MCF7; HT_HG-U133A	RRP1B KDM5C GGA1 TGS1 RAB11FIP3	2.05e-04	198	62	5	1701_DN
Drug	Piperacillin sodium salt [59703-84-3]; Up 200; 7.4uM; PC3; HT_HG-U133A	MED25 PLD1 HUWE1 GGA1 RAB11FIP3	2.05e-04	198	62	5	4320_UP
Drug	Reserpine [50-55-5]; Down 200; 6.6uM; PC3; HT_HG-U133A	FRMPD1 MED25 PTPN18 TGS1 RAB11FIP3	2.05e-04	198	62	5	4203_DN
Drug	Fluorocurarine chloride [22273-09-2]; Down 200; 11.6uM; MCF7; HT_HG-U133A	KDM5C NUP98 CNPY3 PTPN18 ZKSCAN5	2.10e-04	199	62	5	6219_DN
Drug	Kynurenine, 3-hydroxy (R,S) [2147-61-7]; Down 200; 17.8uM; MCF7; HT_HG-U133A	MAP7D3 UBE4B GTSE1 ZKSCAN5 MAP3K2	2.10e-04	199	62	5	2654_DN
Drug	Spironolactone [52-01-7]; Down 200; 9.6uM; PC3; HT_HG-U133A	CLCN5 KDM5C SERPINE1 MED25 GGA1	2.10e-04	199	62	5	2064_DN
Drug	Arecoline hydrobromide [300-08-3]; Down 200; 17uM; PC3; HT_HG-U133A	UBE4B KDM5C MED25 MAPK7 RAB11FIP3	2.10e-04	199	62	5	6322_DN
Drug	Oxymetazoline hydrochloride [2315-02-8]; Down 200; 13.4uM; PC3; HT_HG-U133A	UBE4B KDM5C MED25 PTPN18 MAP3K2	2.10e-04	199	62	5	6350_DN
Drug	Glimepiride [93479-97-1]; Down 200; 8.2uM; PC3; HT_HG-U133A	CLCN5 MED25 MAPK7 ZKSCAN5 TGS1	2.14e-04	200	62	5	6628_DN
Drug	Ipratropium bromide [22254-24-6]; Down 200; 9.8uM; PC3; HT_HG-U133A	CLCN5 UBE4B MAPK7 PTPN18 MAP3K2	2.14e-04	200	62	5	5823_DN
Drug	Cortisone [53-06-5]; Down 200; 11uM; HL60; HT_HG-U133A	KDM5C MED25 PLD1 GGA1 ZKSCAN5	2.14e-04	200	62	5	2385_DN
Drug	Ketotifen fumarate [34580-14-8]; Down 200; 9.4uM; PC3; HT_HG-U133A	MED25 MAPK7 PTPN18 MAP3K2 RAB11FIP3	2.14e-04	200	62	5	5842_DN
Drug	Sirolimus	ERN1 AOPEP SERPINE1 MCL1 TSC1 MAP2K1 TP53	2.35e-04	456	62	7	ctd:D020123
Drug	AC1L45LU	ERN1 MCL1 MAPK7 MAP2K1 TP53	2.40e-04	205	62	5	CID000151069
Drug	Ethacrynic Acid	MCL1 MAP2K1 TP53	2.51e-04	45	62	3	ctd:D004976
Drug	adaphostin	MCL1 MAP2K1 TP53	2.69e-04	46	62	3	CID000387042
Drug	tris(2,3-dibromopropyl)isocyanurate	MCL1 TP53	3.24e-04	10	62	2	ctd:C541743
Drug	hafnium hydroxide	TP53 ALPI	3.24e-04	10	62	2	CID000082817
Drug	MG 262	LONP1 TP53	3.24e-04	10	62	2	ctd:C423917
Drug	wartmannin	SERPINE1 MCL1 TSC1 PLD1 MAPK7 MAP2K1 GOLGB1 TP53 ALPI	3.30e-04	811	62	9	CID000005691
Disease	syndromic X-linked intellectual disability Claes-Jensen type (implicated_via_orthology)	KDM5C KDM5D	2.52e-05	4	61	2	DOID:0060809 (implicated_via_orthology)
Disease	cerebral infarction (implicated_via_orthology)	MAP2 SERPINE1	6.27e-05	6	61	2	DOID:3526 (implicated_via_orthology)
Disease	CHARGE syndrome (implicated_via_orthology)	CHD8 TP53	8.77e-05	7	61	2	DOID:0050834 (implicated_via_orthology)
Disease	renal cell carcinoma	PRKCSH PLD1 MAP2K1	9.11e-05	42	61	3	EFO_0000681
Disease	Acute erythroleukemia - M6a subtype	NUP98 TP53	1.17e-04	8	61	2	C2930975
Disease	Acute myeloid leukemia FAB-M6	NUP98 TP53	1.17e-04	8	61	2	C2930976
Disease	Acute erythroleukemia - M6b subtype	NUP98 TP53	1.17e-04	8	61	2	C2930977
Disease	Acute erythroleukemia	NUP98 TP53	1.17e-04	8	61	2	C2930974
Disease	Adult Hepatocellular Carcinoma	TSC1 TP53	1.50e-04	9	61	2	C0279607
Disease	age at onset, coronary stenosis	PRKCSH PLD1	1.50e-04	9	61	2	EFO_0004847, MONDO_0006715
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	ERN1 KDM5C TSC1 TP53	2.54e-04	148	61	4	C0279702
Disease	autism spectrum disorder (implicated_via_orthology)	KDM5C TSC1 CHD8 KDM5D	2.81e-04	152	61	4	DOID:0060041 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	TRERF1 GUCY1A2 FRMPD1 NUP98 DIP2C GGA1 DNAH9 GOLGB1 TP53	3.43e-04	1074	61	9	C0006142
Disease	Sarcoma, Spindle Cell	MCL1 TP53	3.76e-04	14	61	2	C0205945
Disease	Sarcoma, Epithelioid	MCL1 TP53	3.76e-04	14	61	2	C0205944
Disease	syndromic intellectual disability (implicated_via_orthology)	KDM5C KDM5D	4.95e-04	16	61	2	DOID:0050888 (implicated_via_orthology)
Disease	breast cancer (is_marker_for)	KDM5C SERPINE1 TSC1 MAP2K1	5.91e-04	185	61	4	DOID:1612 (is_marker_for)
Disease	Sarcoma	MCL1 TP53	8.61e-04	21	61	2	C1261473
Disease	Granulomatous Slack Skin	MCL1 TP53	9.46e-04	22	61	2	C0376407
Disease	Lymphoma, T-Cell, Cutaneous	MCL1 TP53	1.03e-03	23	61	2	C0079773
Disease	West Syndrome	CNPY3 TSC1	1.13e-03	24	61	2	C0037769
Disease	glucose measurement	SOX5 ERN1 RFX6 TP53 RAB11FIP3	1.14e-03	380	61	5	EFO_0004468
Disease	Epilepsy	ERN1 KDM5C TSC1	1.51e-03	109	61	3	C0014544
Disease	Neoplasm of uncertain or unknown behavior of ovary	MAP2K1 TP53	1.65e-03	29	61	2	C0496920
Disease	Ovarian Carcinoma	MAP2K1 TP53	1.76e-03	30	61	2	C0029925

Protein segments in the cluster

Peptide	Gene	Start	Entry
PSSPDHMLAMVEEAR	PTPN18	201	Q99952
SSERDFSLIDDPMMP	CHD8	2556	Q9HCK8
AVLPRDSMVEPCSME	ALKBH1	311	Q13686
MDIQLDPARDDLPLM	AOPEP	1	Q8N6M6
MTDGMLLREFLSEPD	DHX16	496	O60231
GMDSRPPMAIFELLD	MAP2K1	301	Q02750
QSDPTPEMDSLMDML	PCP2	56	Q8IVA1
IPATMQEMPESLLAD	RFX6	331	Q8HWS3
ALTMEALEDPSPELM	RAB11FIP3	441	O75154
LSSDDLIPPMDLLEM	INTS15	191	Q96N11
ALRSSEDPMDMEVPL	MAB21L4	71	Q08AI8
MDSPMLLADLPDLQD	MAPK7	801	Q13164
TMLEESMPEDQEPVS	NUP98	961	P52948
PMPEDYAMDELRSLT	NUP98	1791	P52948
EPSRCEYLMELMTPA	PRKCSH	496	P14314
PEAIRAPLEELMMEG	KDM5D	1376	Q9BY66
MELSPRSPPEMLEES	PDE1B	1	Q01064
EFIPESMDQMLDPLS	MAP3K2	191	Q9Y2U5
SMDQMLDPLSLSSPE	MAP3K2	196	Q9Y2U5
VTDTIPEPLRDRMEM	LONP1	641	P36776
PGLQPSVMEDDILMD	MED25	731	Q71SY5
MEPAMEPETLEARIN	GGA1	1	Q9UJY5
PSQAMDDLMLSPDDI	TP53	36	P04637
MMSSNPEEDPLDTFL	NYAP2	6	Q9P242
QMSTSEELDEMPVPD	OSBPL1A	806	Q9BXW6
DMEDSVLAVMPPDIA	HUWE1	3076	Q7Z6Z7
SSDVPLDPLEMHMDM	JUP	706	P14923
ESRPLIDLMTNTPDM	GTSE1	666	Q9NYZ3
PTLDPSLMEMTEAAL	ALPI	301	P09923
SEPRLSVAPEMDIMD	OTULIN	76	Q96BN8
EMEAERLAAMLTLPE	PDP2	486	Q9P2J9
DPMERPMSQADLELD	CBY2	101	Q8NA61
MPRAQLPEDSSAVDM	C5orf60	1	A6NFR6
ARPEAPVDSMLKDMA	ERN1	431	O75460
PASRVMEMEPETMET	FRMPD1	916	Q5SYB0
MDSMPEPASRCLLLL	CNPY3	1	Q9BT09
TAMDFSMRDDVPPLD	CLCN5	36	P51795
MADRSLEGMALPLEV	DIP2C	1	Q9Y2E4
MSMDASPELSIEALP	MAP7D3	356	Q8IWC1
PALDPLRMLMDDADV	DNAH9	3421	Q9NYC9
PQLMPMLEEALRSES	IPO4	351	Q8TEX9
DSPMVMTLVDGPAEE	GARNL3	651	Q5VVW2
MMEGDPDTLAELLIR	FAM153B	211	P0C7A2
APLEEMEAPAADAIM	MCL1	106	Q07820
VSARMAPEEIIMDRP	SERPINE1	366	P05121
MMELSEEVLTPDGRP	GUCY1A2	596	P33402
MLESAVLPPEDMSQS	RRP1B	486	Q14684
PESERPEMLSEQEHM	PUF60	426	Q9UHX1
PRLNSMLMEVEEPEV	NBPF26	821	B4DH59
SLPPAAMESMESLRL	PLD1	511	Q13393
PPDLFARMTAEEMAS	TCEA1	216	P23193
MPSPERLDKVVDSMD	MRPL47	126	Q9HD33
AHSDDRMEPRLLMPN	REELD1	171	A0A1B0GV85
EMRVPDVEVSLPSME	AHNAK2	2106	Q8IVF2
VALAPEELELDPMAM	SF3B2	826	Q13435
LAMLDSPMLGVRDDV	TSC1	11	Q92574
EFRDPLMDTLMTDPV	UBE4B	1231	O95155
LRESSAMASPLPREM	TNKS1BP1	6	Q9C0C2
AMASPLPREMEEELV	TNKS1BP1	11	Q9C0C2
TDHLSMEEEDPMPRQ	TPRG1	26	Q6ZUI0
PLRLESMSLMSRTPD	USF3	1351	Q68DE3
VMAPDLPEMLDLAGT	MAP2	801	P11137
SMEDRMECESPEPHP	ZBED9	171	Q6R2W3
MLTDPDLPQEFERMS	SOX5	1	P35711
ELDSEAELMRSMGLP	TGS1	86	Q96RS0
MIMTESREVIDLDPP	ZKSCAN5	1	Q9Y2L8
PASSMSDDEMPVLEI	TRERF1	616	Q96PN7
MRAPLDPELHQESDM	GOLGB1	26	Q14789
LPEATRAPLEELMME	KDM5C	1391	P41229