Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	ATP7A SLC34A2 SLC10A3 SLC13A2 ATP13A2 SLC36A2 SLC5A2 SLC41A3 SLC18A1	7.10e-05	301	117	9	GO:0022853
GeneOntologyMolecularFunction	solute:monoatomic cation symporter activity	SLC34A2 SLC10A3 SLC13A2 SLC36A2 SLC5A2 SLC18A1	7.20e-05	119	117	6	GO:0015294
GeneOntologyMolecularFunction	solute:sodium symporter activity	SLC34A2 SLC10A3 SLC13A2 SLC5A2 SLC18A1	1.14e-04	81	117	5	GO:0015370
GeneOntologyMolecularFunction	carboxypeptidase activity	NAALADL1 CPZ AGBL5 AGBL1	1.94e-04	49	117	4	GO:0004180
GeneOntologyMolecularFunction	mRNA cap binding	AGO2 EIF4E2	2.03e-04	4	117	2	GO:0098808
GeneOntologyMolecularFunction	symporter activity	SLC34A2 SLC10A3 SLC13A2 SLC36A2 SLC5A2 SLC18A1	2.56e-04	150	117	6	GO:0015293
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC34A2 SLC10A3 SLC13A2 SLC36A2 SLC5A2 SLC41A3 SLC18A1 SLC35D3	3.58e-04	296	117	8	GO:0015291
GeneOntologyMolecularFunction	active transmembrane transporter activity	ATP7A SLC34A2 SLC10A3 SLC13A2 ATP13A2 SLC36A2 SLC5A2 SLC41A3 SLC18A1 SLC35D3	5.03e-04	477	117	10	GO:0022804
GeneOntologyMolecularFunction	N,N-dimethylaniline monooxygenase activity	FMO3 FMO6P	5.03e-04	6	117	2	GO:0004499
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC34A2 SLC10A3 SLC13A2 SLC5A2 SLC41A3 SLC18A1	5.16e-04	171	117	6	GO:0015081
GeneOntologyMolecularFunction	metallocarboxypeptidase activity	CPZ AGBL5 AGBL1	7.82e-04	31	117	3	GO:0004181
Domain	-	RASA4 RASA4B	1.12e-04	3	115	2	4.10.1130.10
Domain	-	PLXNA3 RASA4 RASA4B	1.20e-04	16	115	3	1.10.506.10
Domain	RasGAP_dom	PLXNA3 RASA4 RASA4B	1.73e-04	18	115	3	IPR001936
Domain	Peptidase_M14	CPZ AGBL5 AGBL1	3.68e-04	23	115	3	PF00246
Domain	Peptidase_M14	CPZ AGBL5 AGBL1	3.68e-04	23	115	3	IPR000834
Domain	SSX	SSX2 SSX3	5.55e-04	6	115	2	IPR028804
Domain	HECT	HUWE1 HERC1 HERC4	5.97e-04	27	115	3	PF00632
Domain	HECTc	HUWE1 HERC1 HERC4	5.97e-04	27	115	3	SM00119
Domain	HECT_dom	HUWE1 HERC1 HERC4	5.97e-04	27	115	3	IPR000569
Domain	HECT	HUWE1 HERC1 HERC4	5.97e-04	27	115	3	PS50237
Domain	SSXRD	SSX2 SSX3	1.03e-03	8	115	2	PF09514
Domain	SSXRD_motif	SSX2 SSX3	1.03e-03	8	115	2	IPR019041
Domain	BTK	RASA4 RASA4B	1.32e-03	9	115	2	SM00107
Domain	Znf_Btk_motif	RASA4 RASA4B	1.32e-03	9	115	2	IPR001562
Domain	BTK	RASA4 RASA4B	1.32e-03	9	115	2	PF00779
Domain	ZF_BTK	RASA4 RASA4B	1.32e-03	9	115	2	PS51113
Domain	KRAB_RELATED	SSX2 SSX3	1.99e-03	11	115	2	PS50806
Domain	ZnF_UBP	USP49 USP39	1.99e-03	11	115	2	SM00290
Domain	Rho_GTPase_activation_prot	PLXNA3 ARAP3 RASA4 RASA4B	2.14e-03	88	115	4	IPR008936
Domain	Krueppel-associated_box-rel	SSX2 SSX3	2.80e-03	13	115	2	IPR003655
Domain	RasGAP	RASA4 RASA4B	3.26e-03	14	115	2	SM00323
Domain	Znf_UBP	USP49 USP39	3.26e-03	14	115	2	IPR001607
Domain	ZP_2	ZP1 UMODL1	3.26e-03	14	115	2	PS51034
Domain	zf-UBP	USP49 USP39	3.26e-03	14	115	2	PF02148
Domain	ZP_1	ZP1 UMODL1	3.26e-03	14	115	2	PS00682
Domain	ZF_UBP	USP49 USP39	3.26e-03	14	115	2	PS50271
Domain	RasGAP_CS	RASA4 RASA4B	3.26e-03	14	115	2	IPR023152
Domain	RasGAP	RASA4 RASA4B	3.74e-03	15	115	2	PF00616
Domain	RAS_GTPASE_ACTIV_1	RASA4 RASA4B	3.74e-03	15	115	2	PS00509
Domain	RAS_GTPASE_ACTIV_2	RASA4 RASA4B	3.74e-03	15	115	2	PS50018
Domain	ZP	ZP1 UMODL1	3.74e-03	15	115	2	SM00241
Domain	ZP_dom	ZP1 UMODL1	4.81e-03	17	115	2	IPR001507
Domain	Zona_pellucida	ZP1 UMODL1	4.81e-03	17	115	2	PF00100
Domain	-	FMO3 DAO SMOX	4.97e-03	56	115	3	3.50.50.60
Domain	FAD/NAD-binding_dom	FMO3 DAO SMOX	5.23e-03	57	115	3	IPR023753
Domain	aa-tRNA-synth_I_CS	EARS2 IARS2	5.39e-03	18	115	2	IPR001412
Domain	CARBOXYPEPT_ZN_2	CPZ AGBL1	6.00e-03	19	115	2	PS00133
Domain	AA_TRNA_LIGASE_I	EARS2 IARS2	6.00e-03	19	115	2	PS00178
Pubmed	Interaction between the scaffold proteins CBP by IQGAP1 provides an interface between gene expression and cytoskeletal activity.	HIVEP1 TUBB ANKS1B HUWE1 RBM24	4.07e-06	69	119	5	32238831
Pubmed	CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.	RASA4 RASA4B	1.16e-05	2	119	2	11448776
Pubmed	Duplicated zinc finger protein genes on the proximal short arm of the human X chromosome: isolation, characterization and X-inactivation studies.	ZXDA ZXDB	1.16e-05	2	119	2	8268913
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	1.16e-05	2	119	2	11687802
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	1.16e-05	2	119	2	34910522
Pubmed	An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.	RASA4 RASA4B	1.16e-05	2	119	2	16041389
Pubmed	The DNA sequence of the human X chromosome.	ATP7A RPS6KA3 HUWE1 SSX2 ZXDA ZXDB SSX3 GPR119 MBNL3	1.17e-05	407	119	9	15772651
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PCLO HUWE1 MTMR4 GPR158 SYNE2	1.27e-05	87	119	5	12465718
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	3.47e-05	3	119	2	30801007
Pubmed	CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane.	RASA4 RASA4B	3.47e-05	3	119	2	25637021
Pubmed	BCR-ABL mediated repression of miR-223 results in the activation of MEF2C and PTBP2 in chronic myeloid leukemia.	PTBP2 MEF2C	3.47e-05	3	119	2	23174904
Pubmed	Targeted sequencing identifies genetic polymorphisms of flavin-containing monooxygenase genes contributing to susceptibility of nicotine dependence in European American and African American.	FMO3 FMO6P	3.47e-05	3	119	2	28413702
Pubmed	SSX2-4 expression in early-stage non-small cell lung cancer.	SSX2 SSX3	3.47e-05	3	119	2	24645645
Pubmed	RNA-binding protein Muscleblind-like 3 (MBNL3) disrupts myocyte enhancer factor 2 (Mef2) {beta}-exon splicing.	MEF2C MBNL3	3.47e-05	3	119	2	20709755
Pubmed	Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation.	OR2A7 OR2A4	3.47e-05	3	119	2	27315375
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	RAP1GDS1 SLC10A3 DYSF ORMDL1 SLC41A3 SLC18A1 MGA HERC4	3.74e-05	363	119	8	14691545
Pubmed	Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.	TUBB RASA4 SYNE2	6.58e-05	23	119	3	18320585
Pubmed	Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.	STRC STRCP1	6.93e-05	4	119	2	18849963
Pubmed	A zonal organization of odorant receptor gene expression in the olfactory epithelium.	OR2A7 OR2A4	6.93e-05	4	119	2	7683976
Pubmed	Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.	RASA4 RASA4B	6.93e-05	4	119	2	21460216
Pubmed	Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines.	SSX2 SSX3	6.93e-05	4	119	2	10749136
Pubmed	Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding.	RASA4 RASA4B	6.93e-05	4	119	2	16234249
Pubmed	Deletion of the T-box transcription factor gene, Tbx1, in mice induces differential expression of genes associated with cleft palate in humans.	SLITRK1 NDRG1 GABRA5	9.59e-05	26	119	3	30121012
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	HUWE1 HERC1 HERC4	9.59e-05	26	119	3	26949039
Pubmed	MAEL contributes to gastric cancer progression by promoting ILKAP degradation.	RPS6KA3 MAEL	1.15e-04	5	119	2	29371914
Pubmed	Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics.	HIVEP1 ANKS1B	1.15e-04	5	119	2	19721433
Pubmed	ELAVL1 modulates transcriptome-wide miRNA binding in murine macrophages.	AGO2 MEF2C	1.15e-04	5	119	2	25533351
Pubmed	The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects.	HERC1 HERC4	1.15e-04	5	119	2	15676274
Pubmed	An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.	STRC STRCP1	1.15e-04	5	119	2	24920589
Pubmed	Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans.	FMO3 FMO6P	1.73e-04	6	119	2	12527699
Pubmed	A novel subfamily of mouse cytosolic carboxypeptidases.	AGBL5 AGBL1	1.73e-04	6	119	2	17244818
Pubmed	The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids.	AGBL5 AGBL1	1.73e-04	6	119	2	25103237
Pubmed	Nesprin-2 is a novel scaffold protein for telethonin and FHL-2 in the cardiomyocyte sarcomere.	TCAP SYNE2	1.73e-04	6	119	2	38569934
Pubmed	Human and mouse proteases: a comparative genomic approach.	NAALADL1 OVCH1 FREM1 USP39	1.77e-04	81	119	4	12838346
Pubmed	Atypical E2F repressors and activators coordinate placental development.	NDRG1 AK4 HELLS	1.98e-04	33	119	3	22516201
Pubmed	The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis.	C1orf74 ME2 NEDD9 TM9SF2 USP39 MGA	2.05e-04	245	119	6	19521500
Pubmed	The DNA sequence and biological annotation of human chromosome 1.	FMO3 CIART PTBP2 NUP210L C1orf74 PIGV ATP13A2 FMO6P IARS2 MAEL DUSP10 USH2A	2.24e-04	1031	119	12	16710414
Pubmed	Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions.	RPS6KA3 DUSP10	2.41e-04	7	119	2	11157753
Pubmed	EMC3 regulates mesenchymal cell survival via control of the mitotic spindle assembly.	EMC3 EMC4	2.41e-04	7	119	2	36624844
Pubmed	Role of Rck-Pat1b binding in assembly of processing-bodies.	AGO2 PATL1	2.41e-04	7	119	2	23535175
Pubmed	A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest.	POLH TUBB	2.41e-04	7	119	2	16824193
Pubmed	A family of protein-deglutamylating enzymes associated with neurodegeneration.	AGBL5 AGBL1	2.41e-04	7	119	2	21074048
Pubmed	SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.	HUWE1 ME2 STT3B NUP205 IARS2 NDRG1 CCAR2 AK4 USP39	2.50e-04	607	119	9	39147351
Pubmed	Comparative Multiplexed Interactomics of SARS-CoV-2 and Homologous Coronavirus Nonstructural Proteins Identifies Unique and Shared Host-Cell Dependencies.	STT3B TM9SF2 EIF4E2	2.57e-04	36	119	3	33263384
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	EMC3 AGO2 RNGTT HUWE1 MTMR4 SYNE2 CCAR2 DUSP10 HERC1 PLK4 SNTB2 HELLS	2.62e-04	1049	119	12	27880917
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	RAP1GDS1 EMC3 EMC4 HUWE1 NUP205 FOCAD IARS2 NDRG1 TM9SF2 CCAR2 AK4 HERC1	2.90e-04	1061	119	12	33845483
Pubmed	Saturation mutagenesis defines novel mouse models of severe spine deformity.	OR2A7 OR2A4	3.21e-04	8	119	2	34142127
Pubmed	The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP.	SSX2 SSX3	3.21e-04	8	119	2	12007189
Pubmed	Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.	STRC STRCP1	3.21e-04	8	119	2	21165971
Pubmed	Gene expression in mouse oocytes and preimplantation embryos: use of suppression subtractive hybridization to identify oocyte- and embryo-specific genes.	ZP1 UMODL1	3.21e-04	8	119	2	12493692
Pubmed	Comparative genome mapping in the sequence-based era: early experience with human chromosome 7.	RASA4 RASA4B	3.21e-04	8	119	2	10810084
Pubmed	Human transcription factor protein interaction networks.	HIVEP1 AGO2 POLH PATL1 MEF2C ZFPM2 NUP205 MRPS18A SYNE2 CCAR2 HERC1 MGA SNTB2 HELLS	3.87e-04	1429	119	14	35140242
Pubmed	POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1.	PLXNA3 PCLO TUBB GPATCH2 SYNE2 HERC1	3.96e-04	277	119	6	30745168
Pubmed	Proteomic identification of brain proteins that interact with dynein light chain LC8.	POLH TUBB ME2	4.07e-04	42	119	3	14760703
Pubmed	Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity.	AGBL5 AGBL1	4.11e-04	9	119	2	26829768
Pubmed	ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer.	USP49 USP39	4.11e-04	9	119	2	29669287
Pubmed	Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N = 1345 young and elderly subjects.	FMO3 FMO6P	4.11e-04	9	119	2	22903471
Pubmed	Molecular basis for GIGYF-Me31B complex assembly in 4EHP-mediated translational repression.	PATL1 EIF4E2	4.11e-04	9	119	2	31439631
Pubmed	Dnmt3b recruitment through E2F6 transcriptional repressor mediates germ-line gene silencing in murine somatic tissues.	MAEL HELLS	4.11e-04	9	119	2	20439742
Pubmed	Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	POGK DNAH2 CCDC88C MBD5	4.44e-04	103	119	4	10819331
Pubmed	A directed protein interaction network for investigating intracellular signal transduction.	PLXNA3 POGK RPS6KA3 ATP13A2 TCAP FOCAD CCDC88C SLC41A3 SYNE2 AK4 DUSP10 PLK4	4.86e-04	1124	119	12	21900206
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	CACNB2 ATP7A RNGTT PTBP2 ELOVL1 ANKS1B SLC10A3 MEF2C NEDD9 DUSP10 RBM24 ZNF333 PLK4	4.96e-04	1293	119	13	15342556
Pubmed	Brn3a regulates the transition from neurogenesis to terminal differentiation and represses non-neural gene expression in the trigeminal ganglion.	ZFPM2 RASA4 RASA4B	4.99e-04	45	119	3	19877281
Pubmed	The ER membrane protein complex is a transmembrane domain insertase.	EMC3 EMC4	5.13e-04	10	119	2	29242231
Pubmed	A comparative transcriptional map of a region of 250 kb on the human and mouse X chromosome between the G6PD and the FLN1 genes.	PLXNA3 SLC10A3	5.13e-04	10	119	2	7490070
Pubmed	Structural basis for membrane insertion by the human ER membrane protein complex.	EMC3 EMC4	5.13e-04	10	119	2	32439656
Pubmed	EMC Is Required to Initiate Accurate Membrane Protein Topogenesis.	EMC3 EMC4	5.13e-04	10	119	2	30415835
Pubmed	The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins.	EMC3 EMC4	5.13e-04	10	119	2	29809151
Pubmed	CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors.	STAP1 ARAP3	6.26e-04	11	119	2	15090612
Pubmed	Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.	STRC STRCP1	6.26e-04	11	119	2	31448880
Pubmed	Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.	STRC STRCP1	6.26e-04	11	119	2	31776257
Pubmed	p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling.	RPS6KA3 ANKS1B	7.49e-04	12	119	2	16537434
Pubmed	IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development.	AGBL5 AGBL1	7.49e-04	12	119	2	28794449
Pubmed	M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere.	TCAP MEF2C	8.83e-04	13	119	2	16702235
Pubmed	Zbtb20 defines a hippocampal neuronal identity through direct repression of genes that control projection neuron development in the isocortex.	MEF2C ZFPM2	8.83e-04	13	119	2	23283686
Pubmed	EMC3 coordinates surfactant protein and lipid homeostasis required for respiration.	EMC3 EMC4	8.83e-04	13	119	2	29083321
Pubmed	Transcriptional activation of BMP-4 and regulation of mammalian organogenesis by GATA-4 and -6.	MEF2C ZFPM2	8.83e-04	13	119	2	12606287
Pubmed	Evolution of odorant receptors expressed in mammalian testes.	OR2A7 OR2A4	8.83e-04	13	119	2	11014824
Pubmed	Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci.	PLXNA3 SLC10A3	1.03e-03	14	119	2	8733135
Pubmed	Venous endothelin modulates responsiveness of cardiac sympathetic axons to arterial semaphorin.	PLXNA3 MEF2C	1.03e-03	14	119	2	30735130
Pubmed	Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb.	OR2A7 OR2A4	1.03e-03	14	119	2	7528109
Pubmed	Trappc9 deficiency causes parent-of-origin dependent microcephaly and obesity.	AGO2 GABRA5	1.03e-03	14	119	2	32877400
Pubmed	FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.	EMC3 AGO2 TUBB STT3B MTMR4	1.05e-03	223	119	5	34226595
Pubmed	Transcriptomic analysis of polyamine-related genes and polyamine levels in placenta, yolk sac and fetus during the second half of mouse pregnancy.	DAO SMOX	1.18e-03	15	119	2	19131104
Pubmed	Transmembrane insertases and N-glycosylation critically determine synthesis, trafficking, and activity of the nonselective cation channel TRPC6.	EMC3 EMC4 STT3B	1.34e-03	63	119	3	31266804
Pubmed	Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.	CACNB2 ANKS1B ZFPM2	1.46e-03	65	119	3	23453885
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PLXNA3 SLC10A3 LRRK1 HUWE1 DYSF ATP13A2 FOCAD CCDC88C ARAP3 HERC1 MBD5	1.47e-03	1105	119	11	35748872
Pubmed	Proteome-wide Identification of HtrA2/Omi Substrates.	TUBB CCAR2	1.53e-03	17	119	2	17266347
Pubmed	MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders.	MEF2C GABRA5	1.53e-03	17	119	2	27779093
Pubmed	Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.	STRC STRCP1	1.53e-03	17	119	2	20856818
Pubmed	A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.	USP49 AGO2 SLC34A2 IARS2 SYNE2 MAEL	1.60e-03	363	119	6	25036637
Pubmed	DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy.	PLXNA3 AGO2 SLC13A2 TCAP STRC ZNF333	1.62e-03	364	119	6	31391242
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	POGK RPS6KA3 HUWE1 ZXDA STAP1 NDRG1 SNTB2	1.77e-03	503	119	7	16964243
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CACNB2 AGO2 PTBP2 GPATCH2 PATL1 HUWE1 SSX2 ME2 CFAP20DC NDRG1 SLC41A3 GPR158 MBD5	1.79e-03	1489	119	13	28611215
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	EMC3 EMC4 EARS2 PCLO HUWE1 ME2 STT3B MRPS18A IARS2 SYNE2 CCAR2 AK4 HERC1	1.86e-03	1496	119	13	32877691
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	EMC3 EMC4 PCLO TUBB ANKS1B CPZ HUWE1 STT3B NDRG1 GPR158 GABRA5	1.87e-03	1139	119	11	36417873
Pubmed	Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.	AGO2 MEF2C AGBL1	1.88e-03	71	119	3	23400010
Pubmed	Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo.	MEF2C IZUMO1	1.91e-03	19	119	2	21060863
Pubmed	Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study.	MTMR4 CYP2R1	1.91e-03	19	119	2	25208829
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	RNGTT RPS6KA3 HUWE1 STT3B NUP205 MTMR4 ARAP3 CCAR2 DUSP10 SNTB2	1.93e-03	974	119	10	28675297
Cytoband	1q41	GPATCH2 IARS2 DUSP10 USH2A	2.73e-05	66	119	4	1q41
Cytoband	Ensembl 112 genes in cytogenetic band chr1q41	GPATCH2 IARS2 DUSP10 USH2A	1.05e-04	93	119	4	chr1q41
Cytoband	Ensembl 112 genes in cytogenetic band chr1q24	FMO3 POGK FMO6P MAEL	3.68e-04	129	119	4	chr1q24
Cytoband	Ensembl 112 genes in cytogenetic band chr6p24	HIVEP1 NEDD9 ERVFRD-1	8.19e-04	70	119	3	chr6p24
Cytoband	1q24.3	FMO3 FMO6P	1.23e-03	20	119	2	1q24.3
GeneFamily	Solute carriers	SLC34A2 SLC10A3 SLC13A2 SLC36A2 SLC5A2 SLC41A3 SLC18A1 SLC35D3	2.73e-04	395	77	8	752
GeneFamily	Pleckstrin homology domain containing\|SH2 domain containing\|C2 and RasGAP domain containing	RASA4 RASA4B	7.88e-04	10	77	2	830
Coexpression	GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_UP	ATP7A RNGTT ME2 NEDD9 NDRG1 AK4 SMOX	3.95e-06	143	118	7	M1317
Coexpression	GROSS_HYPOXIA_VIA_ELK3_AND_HIF1A_UP	ATP7A RNGTT ME2 NEDD9 NDRG1 AK4 SMOX	5.18e-06	149	118	7	MM1129
Coexpression	HE_LIM_SUN_FETAL_LUNG_C1_PULMONARY_NE_PRECURSOR_CELL	CACNB2 NAALADL1 PCLO FREM1 SLC18A1 RASA4 SLC35D3 RASA4B DUSP10	9.99e-06	304	118	9	M45711
Coexpression	GSE37301_LYMPHOID_PRIMED_MPP_VS_CD4_TCELL_DN	RAP1GDS1 HSD17B7 DYSF STAP1 IARS2 USP39 PLK4	3.28e-05	198	118	7	M8859
Coexpression	GSE28237_FOLLICULAR_VS_LATE_GC_BCELL_UP	HSD17B7 ZFPM2 NDRG1 HERC1 RBM24 MGA IGSF23	3.39e-05	199	118	7	M4886
Coexpression	WANG_LMO4_TARGETS_UP	PHACTR2 TUBB SLC10A3 ZXDB NDRG1 TM9SF2 GPR158 MBNL3 HELLS	4.77e-05	371	118	9	M4735
CoexpressionAtlas	DevelopingGonad_P2_epididymis_emap-30199_k-means-cluster#4_top-relative-expression-ranked_1000	CACNB2 ATP7A SYNE2 HERC1 MBNL3 SNTB2	7.76e-06	90	111	6	gudmap_developingGonad_P2_epididymis_1000_k4
CoexpressionAtlas	DevelopingGonad_e18.5_epididymis_emap-13166_k-means-cluster#4_top-relative-expression-ranked_1000	ATP7A SYNE2 HERC1 MBNL3 SNTB2 HELLS	1.20e-05	97	111	6	gudmap_developingGonad_e18.5_epididymis_1000_k4
CoexpressionAtlas	DevelopingGonad_e18.5_epididymis_emap-13166_k-means-cluster#3_top-relative-expression-ranked_500	ATP7A SYNE2 HERC1 SNTB2 HELLS	2.66e-05	67	111	5	gudmap_developingGonad_e18.5_epididymis_500_k3
CoexpressionAtlas	DevelopingGonad_P2_epididymis_emap-30199_k-means-cluster#3_top-relative-expression-ranked_500	ATP7A SYNE2 SNTB2 HELLS	3.66e-05	36	111	4	gudmap_developingGonad_P2_epididymis_500_k3
ToppCell	5'-Adult-LargeIntestine-Hematopoietic-B_cells-Cycling_B_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MEF2C STAP1 CFAP20DC SYNE2 CKAP2L HELLS	7.18e-06	173	119	6	b7e0193fd4983cb38d1bee441f608f73ee8743b9
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAO SLC13A2 SLC5A2 NDRG1 SLC18A1 AK4	9.59e-06	182	119	6	faf0dfa3adc2d2706b6942b5127093ccdc856447
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DAO SLC13A2 SLC5A2 NDRG1 SLC18A1 AK4	9.59e-06	182	119	6	be8dd52898525ce6632af0adc2801944f3ac10bd
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	HIVEP1 PTBP2 RPS6KA3 NEDD9 NDRG1 MBD5	1.34e-05	193	119	6	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	FMO3 GPATCH2 SLC34A2 NEDD9 SYNE2 DDX43	1.50e-05	197	119	6	b94645d57efe8d9e032bffb8c89af1f425c6421e
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DAO SLC13A2 SLC36A2 SLC5A2 ENTPD5 AK4	1.59e-05	199	119	6	4bde35e5df019189433d65d415e29a0c1145ac66
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW08-Stem_cells-Neuroepithelial_cell\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	EARS2 POLH CCDC88C CKAP2L PLK4 HELLS	1.64e-05	200	119	6	4e077aa7faddcebdfc54667f8b3990704441005b
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW08-Stem_cells\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	EARS2 POLH CCDC88C CKAP2L PLK4 HELLS	1.64e-05	200	119	6	d17ba4239e1fd702a3d757687110f0f2c6f91ef7
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DAO SLC13A2 SLC36A2 SLC5A2 ENTPD5 AK4	1.64e-05	200	119	6	825aad08431dd6b54aa636ace6efc821dfaf8014
Disease	vascular endothelial growth factor measurement	POLH DNAH2 MEF2C ZFPM2 MRPS18A	2.06e-06	56	109	5	EFO_0004762
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	1.35e-05	2	109	2	DOID:0110471 (implicated_via_orthology)
Disease	S-methylcysteine measurement	FMO3 FMO6P	1.35e-05	2	109	2	EFO_0800054
Disease	response to olanzapine	HIVEP1 ANKS1B ZFPM2	2.16e-05	15	109	3	GO_0097333
Disease	congenital diaphragmatic hernia (is_implicated_in)	FREM1 ZFPM2	8.07e-05	4	109	2	DOID:3827 (is_implicated_in)
Disease	vascular endothelial growth factor A, isoform 121 measurement	ZFPM2 MRPS18A	4.79e-04	9	109	2	EFO_0020847
Disease	immature platelet count	TUBB MEF2C ZFPM2 AK4	6.55e-04	106	109	4	EFO_0803544
Disease	handedness	TUBB ANKS1B NDRG1 SNTB2	6.55e-04	106	109	4	EFO_0009902
Disease	congenital diaphragmatic hernia (implicated_via_orthology)	FREM1 ZFPM2	8.71e-04	12	109	2	DOID:3827 (implicated_via_orthology)
Disease	vascular endothelial growth factor A measurement	ZFPM2 MRPS18A	8.71e-04	12	109	2	EFO_0010804
Disease	disks large homolog 3 measurement	MEF2C ZFPM2	8.71e-04	12	109	2	EFO_0802472
Disease	tumor necrosis factor receptor superfamily member EDAR measurement	MEF2C ZFPM2	8.71e-04	12	109	2	EFO_0008310
Disease	platelet measurement	TUBB MEF2C SLC36A2 ZFPM2 CKAP2L AK4	1.14e-03	315	109	6	EFO_0005036
Disease	lentiform nucleus measurement	FMO3 FMO6P	1.20e-03	14	109	2	EFO_0004913
Disease	Autosomal recessive limb-girdle muscular dystrophy	DYSF TCAP	1.20e-03	14	109	2	cv:C2931907
Disease	neuroticism measurement, cognitive function measurement	HIVEP1 AGO2 NUP210L PCLO ANKS1B STT3B NEDD9 AGBL1	1.22e-03	566	109	8	EFO_0007660, EFO_0008354
Disease	matrix metalloproteinase 1 measurement	ZFPM2 CKAP2L	1.38e-03	15	109	2	EFO_0010588
Disease	amyotrophic lateral sclerosis, age at onset	ANKS1B SLC18A1	1.38e-03	15	109	2	EFO_0004847, MONDO_0004976
Disease	cochlin measurement	MEF2C ZFPM2	1.57e-03	16	109	2	EFO_0801481
Disease	red blood cell density measurement	USP49 HIVEP1 TUBB DNAH2 GPATCH2 MEF2C ZFPM2 NUP205 FOCAD HERC4	1.58e-03	880	109	10	EFO_0007978
Disease	Bipolar Disorder	CACNB2 PCLO DAO ME2 SLC18A1 MBD5 GABRA5	2.00e-03	477	109	7	C0005586
Disease	response to heparin, antibody measurement	ANKS1B RBM24	2.46e-03	20	109	2	EFO_0004556, EFO_0006816
Disease	energy expenditure measurement	GPATCH2 GPR158	2.46e-03	20	109	2	EFO_0008005
Disease	alpha-tocopherol measurement	CFAP20DC USH2A	2.46e-03	20	109	2	EFO_0007898
Disease	Congenital diaphragmatic hernia	FREM1 ZFPM2	2.71e-03	21	109	2	C0235833
Disease	muscular dystrophy (implicated_via_orthology)	DYSF SNTB2	2.71e-03	21	109	2	DOID:9884 (implicated_via_orthology)
Disease	mean reticulocyte volume	USP49 AGO2 NUP210L DNAH2 MEF2C NUP205 LPIN2 AK4 SMOX	2.87e-03	799	109	9	EFO_0010701
Disease	nucleus accumbens volume	STT3B USH2A	2.98e-03	22	109	2	EFO_0006931
Disease	peripheral neuropathy, response to antimicrotubule agent	SLITRK1 ZFPM2	3.25e-03	23	109	2	EFO_0003100, EFO_0005260
Disease	response to clopidogrel, cardiovascular event measurement	DYSF FREM1	3.25e-03	23	109	2	EFO_0006919, GO_1903493
Disease	congenital diaphragmatic hernia (biomarker_via_orthology)	ATP7A FREM1	3.54e-03	24	109	2	DOID:3827 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
RLKLTVQDPGFPMGI	UMODL1	466	Q5DID0
MSQFKRQRINPLPGG	CCAR2	1	Q8N163
FKLIPMLNPDGVVRG	AGBL5	286	Q8NDL9
LARQKFGTMPLLPIR	ARAP3	1341	Q8WWN8
PGNRVKLLIGPMQET	NEDD9	56	Q14511
QTLGMGKRRSPPQAI	C1orf74	21	Q96LT6
KLISFQPPQLGRTNM	C5orf64	16	Q2M2E5
GRKNLYTAMPLPIGR	AGO2	96	Q9UKV8
IFKIIPMLNPDGVIN	AGBL1	836	Q96MI9
GFIPSPVKLENMRLQ	CACNB2	171	Q08289
PIAAGVFMPIGLVLQ	ATP7A	1371	Q04656
KLGMQGPGQLIPLIE	RASA4	281	O43374
KPRIMQPGFAFGVQQ	RBM24	91	Q9BX46
KLGMQGPGQLIPLIE	RASA4B	281	C9J798
IPYLKMLQGLANGPQ	NUP205	511	Q92621
RDPLLQPGRGQIMKV	DAO	191	P14920
ILQAIQLLPKMRPIG	ANKS1B	866	Q7Z6G8
SPLAAMNPKLLQGRV	PATL1	291	Q86TB9
PFRLQNPGQLLQLGM	MIR7-3HG	71	Q8N6C7
TIALMIQRGVPGPFL	HELLS	261	Q9NRZ9
TFVQKMPGQLPILEG	ENTPD5	66	O75356
LMPLNGVLRKEPVFN	FMO3	271	P31513
PLRRPGMLVPKQNVS	MAEL	81	Q96JY0
RGQPVAGRFLPLKTM	RNGTT	16	O60942
LVMTPQGQLLTLKGP	MGA	2596	Q8IWI9
LVRAFLQPPLKGVVM	ASPG	251	Q86U10
MIIVGPPRQGKSTLL	LRRK1	641	Q38SD2
GLQPNLVPEFRGVMK	GPR158	291	Q5T848
MASKLLRAVILGPPG	AK4	1	P27144
MLFKRNPANRLGAGP	RPS6KA3	301	P51812
SLPLLPKNRGMVIVN	ZFPM2	1031	Q8WW38
MLGQPLQLLPKTGVS	HERC1	1791	Q15751
LPNVLMIGRDPLSGK	CCDC88C	101	Q9P219
KRPIISPNLNFMGQL	DUSP10	441	Q9Y6W6
NLFPIPRIGKMGQNG	PCLO	4971	Q9Y6V0
GMQLEKRPPGFLGLL	PNMA6E	471	A0A0J9YXQ4
VGVMQPLTLRAKNLP	PLXNA3	696	P51805
QSPQPMLLGLLGQFL	SLC10A3	221	P09131
MLPGVLQQFGLKSII	NDRG1	121	Q92597
PQLLKSLLGIPFMQV	HERC4	181	Q5GLZ8
IRAGIPNQIPKAAFM	FREM1	286	Q5H8C1
IGFLPLGIPMFQQTA	GPR119	136	Q8TDV5
LGMNNRKPDLRVLIP	MEF2C	246	Q06413
MQLRKGPNVVGPYGL	MT-ND1	31	P03886
FKGPMQRLPLNNLLA	GABRA5	111	P31644
LMPLNGSLRKEPVFN	FMO6P	271	O60774
PRNLVLVATKMPLGQ	METTL25B	451	Q96FB5
ELGKTVPQLLTPGLM	PHACTR2	406	O75167
VPKQRGMLILNGFRG	POGK	461	Q9P215
FLLLGFPVGPRIQML	OR2A7	11	Q96R45
IPKMPQLHGVRIFGI	ORMDL1	136	Q9P0S3
QKRPLGGRELQLPSM	HUWE1	3696	Q7Z6Z7
NGQLLENPRFGKMPL	MTMR4	871	Q9NYA4
FLLLGFPVGPRIQML	OR2A4	11	O95047
LMPGIKVGRSRAQLP	FCSK	891	Q8N0W3
MGVVPLKGQAFLPLV	ATP13A2	526	Q9NQ11
MPLKTFPAAIRGVIQ	IGSF23	46	A1L1A6
RVDFILQPLGMGPKN	CPZ	576	Q66K79
GVRQLLKQRRPMGFP	CYP2R1	26	Q6VVX0
PPVQFKLLGTLRMLI	RAP1GDS1	416	P52306
RLNLKMFPVIGSPLA	HYAL4	66	Q2M3T9
FVLSLGPRIMANRKP	ELOVL1	41	Q9BW60
GPRIMANRKPFQLRG	ELOVL1	46	Q9BW60
AGIMPNPQLNIKALF	HSD17B7	91	P56937
AMALQPGTLQLIPKR	MBNL3	256	Q9NUK0
QMLGLQGLLPPKIET	ME2	46	P23368
VKSQPGLLGMPLNQI	MBD5	551	Q9P267
QPLQPEKMLASRLLG	IZUMO1	281	Q8IYV9
PFPLTLRFKPMLQQG	EMC3	141	Q9P0I2
DIALGPLKQIPMNLF	EMC4	71	Q5J8M3
PIQAMQRPKGLGLGF	GPATCH2	496	Q9NW75
IKMPGRLGPQRLLFQ	EIF4E2	221	O60573
NLGSRFIEPPVLNMK	DNAH2	3811	Q9P225
IVGVRPAPLILGFML	SLC13A2	116	Q13183
FLGSLQLDLNRMPKP	DYSF	1921	O75923
LQPSLKGQRNRPGML	DDX43	306	Q9NXZ2
KGQRNRPGMLVLTPT	DDX43	311	Q9NXZ2
VPNLIPVLMFKLGRP	FOCAD	486	Q5VW36
SKNGMQRILIPFIPA	NUP210L	1681	Q5VU65
VVPLMLSNILGAQKP	OR10Q1	81	Q8NGQ4
VNGLQPPIKVMTLGR	USH2A	191	O75445
MLIGVLVLKNGAPSP	SLC35D3	116	Q5M8T2
IALGLPFGKVTNILM	PTBP2	76	Q9UKA9
NIKRPPGDIMFLLVQ	USP39	261	Q53GS9
LPQTGMKPLPVFQRT	SYNE2	3956	Q8WXH0
LLTKPEGIMQIPRNS	OVCH1	986	Q7RTY7
PLAVKNAGILMGPLS	SLC36A2	76	Q495M3
RPQMTFGRLQGIFPK	SSX3	96	Q99909
QFIRPHGGMLPRKIT	MRPS18A	91	Q9NVS2
QRVLPLPIFTPAKMG	TCAP	86	O15273
VPPLVGLKGNLEMTL	SLC41A3	106	Q96GZ6
GSVPQLFSQMPIRKI	POLH	241	Q9Y253
LPQTSFPMKLLGRQQ	IARS2	66	Q9NSE4
MFQGLRTPQLTPGRK	SPATA31C1	976	P0DKV0
RLLIGQPLPNKMTVF	PLK4	311	O00444
MLQGKLQGKLQVPPS	STRC	761	Q7RTU9
KLLRMALSGQQQGPP	EARS2	486	Q5JPH6
VLGPPPLSGRRNNMK	CFAP20DC	141	Q6ZVT6
PPLTDLLNGLKMGRF	CIART	131	Q8N365
GIKLQIGPIPRINGM	CKAP2L	661	Q8IYA6
PFTRLPIRMAKGLGN	SLC34A2	506	O95436
GQKVPRNPIMGLLYH	PIGV	446	Q9NUD9
MEIPKLLPARGTLQG	ZXDB	1	P98169
KGMQLLVFPRPGQTL	ZP1	46	P60852
LILPGTFNAMPKLRI	SLITRK1	461	Q96PX8
RPQMTFGRLQGISPK	SSX2	96	Q16385
GPIFTNINLMGIAPI	ERVFRD-1	111	P60508
YPRLVVKLMPNGLRG	SLC5A2	366	P31639
GLILSMQIPFVGFQP	STT3B	301	Q8TCJ2
LQKNPSLGNMILRPG	STAP1	191	Q9ULZ2
MLRQFTGNPNIPKPR	SMOX	451	Q9NWM0
IPPRGLKMAVTFIGN	TUBB	356	P07437
KLRRQPAMAPGVTGL	USP49	241	Q70CQ1
QMGPGLFLRMQLVPS	ZNF333	101	Q96JL9
FRPPRKGMLLSVFLG	TM9SF2	356	Q99805
MEIPKLLPARGTLQG	ZXDA	1	P98168
MLQGKLQGKLQVPPS	STRCP1	761	A6NGW2
NRMPILISKIFPGLA	SNTB2	136	Q13425
ALPTGEKALLLPGQM	HIVEP1	721	P15822
GGLYLKVPQMPSLLQ	GTF2H3	211	Q13889
KAVMQLLVNPFVGPL	SLC18A1	146	P54219
VNDKGTILPRGPLML	LPIN2	751	Q92539
TLQKGSPDPLQVRML	NAALADL1	641	Q9UQQ1