Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionscaffold protein binding

SYK XIAP GRID2 BIRC8 SCN5A

2.56e-0793305GO:0097110
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN1A SCN5A SCN8A

7.77e-0626303GO:0005248
GeneOntologyMolecularFunctionsodium channel activity

SCN1A SCN5A SCN8A

6.44e-0552303GO:0005272
GeneOntologyMolecularFunctionsodium ion binding

SCN1A SCN8A

1.96e-0414302GO:0031402
GeneOntologyMolecularFunctioncysteine-type endopeptidase inhibitor activity involved in apoptotic process

XIAP BIRC8

5.90e-0424302GO:0043027
GeneOntologyMolecularFunctionprotein serine/threonine kinase binding

XIAP BIRC8

5.90e-0424302GO:0120283
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

XIAP AREL1 BIRC8 HUWE1 FBXO3

6.38e-04473305GO:0004842
GeneOntologyMolecularFunctionalkali metal ion binding

SCN1A SCN8A

6.93e-0426302GO:0031420
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

XIAP AREL1 BIRC8 HUWE1 FBXO3

9.11e-04512305GO:0019787
GeneOntologyMolecularFunctionaminoacyltransferase activity

XIAP AREL1 BIRC8 HUWE1 FBXO3

1.08e-03532305GO:0016755
GeneOntologyMolecularFunctionprotein kinase binding

SYK XIAP BIRC8 CDC5L CCNK SCN5A

1.66e-03873306GO:0019901
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SCN1A SCN5A SCN8A

2.11e-03171303GO:0015081
GeneOntologyMolecularFunctionubiquitin protein ligase activity

XIAP AREL1 BIRC8 HUWE1

2.21e-03372304GO:0061630
GeneOntologyMolecularFunctionkinase binding

SYK XIAP BIRC8 CDC5L CCNK SCN5A

2.80e-03969306GO:0019900
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

XIAP AREL1 BIRC8 HUWE1

2.83e-03398304GO:0061659
GeneOntologyMolecularFunctioncysteine-type endopeptidase regulator activity involved in apoptotic process

XIAP BIRC8

2.97e-0354302GO:0043028
GeneOntologyMolecularFunctioncalcium-dependent phospholipid binding

DYSF SYT7

3.66e-0360302GO:0005544
GeneOntologyMolecularFunctionmonoatomic ion channel activity

GRID2 SCN1A SCN5A SCN8A

4.70e-03459304GO:0005216
GeneOntologyMolecularFunctionacyltransferase activity

XIAP AREL1 BIRC8 HUWE1 FBXO3

5.53e-03775305GO:0016746
GeneOntologyMolecularFunctionchannel activity

GRID2 SCN1A SCN5A SCN8A

7.53e-03525304GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

GRID2 SCN1A SCN5A SCN8A

7.58e-03526304GO:0022803
GeneOntologyMolecularFunctionmethylation-dependent protein binding

L3MBTL3 CHD5

7.71e-0388302GO:0140034
GeneOntologyMolecularFunctionprotein domain specific binding

SYK GRID2 CDC5L TOP1 SCN5A

9.15e-03875305GO:0019904
GeneOntologyBiologicalProcessregulation of apoptosis involved in tissue homeostasis

XIAP BIRC8

6.55e-063312GO:0060785
GeneOntologyBiologicalProcessmembrane depolarization during action potential

SCN1A SCN5A SCN8A

2.12e-0536313GO:0086010
GeneOntologyBiologicalProcessinhibition of cysteine-type endopeptidase activity

XIAP BIRC8

9.76e-0510312GO:0097340
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

SCN1A SCN5A SCN8A

1.09e-0462313GO:0086002
GeneOntologyBiologicalProcessneuronal action potential

SCN1A SCN5A SCN8A

1.15e-0463313GO:0019228
GeneOntologyBiologicalProcesszymogen inhibition

XIAP BIRC8

1.19e-0411312GO:0097341
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN1A SCN5A SCN8A

1.98e-0617313GO:0001518
GeneOntologyCellularComponentsodium channel complex

SCN1A SCN5A SCN8A

1.05e-0529313GO:0034706
GeneOntologyCellularComponentearly phagosome

SYK SYT7

1.92e-0414312GO:0032009
GeneOntologyCellularComponentT-tubule

DYSF SCN1A SCN5A

2.16e-0479313GO:0030315
GeneOntologyCellularComponentnode of Ranvier

SCN1A SCN8A

3.98e-0420312GO:0033268
GeneOntologyCellularComponentaxon initial segment

SCN1A SCN8A

8.43e-0429312GO:0043194
GeneOntologyCellularComponentplasma membrane protein complex

SYK GRID2 HLA-DQA1 SCN1A SCN5A SCN8A

9.06e-04785316GO:0098797
GeneOntologyCellularComponentZ disc

SCN1A SCN5A SCN8A

1.43e-03151313GO:0030018
GeneOntologyCellularComponentparallel fiber to Purkinje cell synapse

GRID2 SCN8A

1.85e-0343312GO:0098688
GeneOntologyCellularComponentI band

SCN1A SCN5A SCN8A

1.88e-03166313GO:0031674
GeneOntologyCellularComponentmonoatomic ion channel complex

GRID2 SCN1A SCN5A SCN8A

2.25e-03378314GO:0034702
GeneOntologyCellularComponentendocytic vesicle

SYK DYSF SYT7 HLA-DQA1

2.38e-03384314GO:0030139
GeneOntologyCellularComponentsarcolemma

DYSF SCN1A SCN5A

2.75e-03190313GO:0042383
HumanPhenoGaze-evoked nystagmus

GRID2 SACS SCN1A SCN8A

1.52e-0555154HP:0000640
MousePhenoabnormal head movements

COL2A1 GRID2 SCN1A SCN8A

4.28e-05103274MP:0000436
MousePhenoventricular fibrillation

SCN1A SCN5A

7.50e-057272MP:0006110
MousePhenoabnormal action potential

GRID2 SCN1A SCN5A SCN8A

1.16e-04133274MP:0005402
MousePhenodecreased cerebellar granule cell number

GRID2 SCN8A

1.60e-0410272MP:0008924
MousePhenoabnormal stationary movement

COL2A1 GRID2 SCN1A SCN8A

1.71e-04147274MP:0001388
MousePhenocongestive heart failure

XIAP BIRC8 SCN5A

2.25e-0462273MP:0006138
MousePhenoabnormal muscle physiology

XIAP GRID2 BIRC8 DYSF SACS SYT7 SCN5A SCN8A

3.15e-04954278MP:0002106
MousePhenofibrillation

SCN1A SCN5A

3.22e-0414272MP:0006109
DomainNa_trans_cytopl

SCN1A SCN5A SCN8A

8.25e-086313PF11933
DomainNa_trans_cytopl

SCN1A SCN5A SCN8A

8.25e-086313IPR024583
DomainNa_channel_asu

SCN1A SCN5A SCN8A

4.93e-0710313IPR001696
DomainNa_trans_assoc

SCN1A SCN5A SCN8A

4.93e-0710313IPR010526
DomainNa_trans_assoc

SCN1A SCN5A SCN8A

4.93e-0710313PF06512
DomainIQ

ADGB SCN1A SCN5A SCN8A

9.45e-0681314SM00015
DomainIQ_motif_EF-hand-BS

ADGB SCN1A SCN5A SCN8A

1.44e-0590314IPR000048
DomainIQ

ADGB SCN1A SCN5A SCN8A

1.64e-0593314PS50096
DomainBIR

XIAP BIRC8

7.42e-058312SM00238
DomainBIR_REPEAT_2

XIAP BIRC8

7.42e-058312PS50143
Domain-

XIAP BIRC8

7.42e-0583121.10.1170.10
DomainBIR_rpt

XIAP BIRC8

7.42e-058312IPR001370
DomainBIR_REPEAT_1

XIAP BIRC8

7.42e-058312PS01282
DomainBIR

XIAP BIRC8

7.42e-058312PF00653
DomainChannel_four-helix_dom

SCN1A SCN5A SCN8A

1.14e-0457313IPR027359
Domain-

SCN1A SCN5A SCN8A

1.14e-04573131.20.120.350
DomainIon_trans_dom

SCN1A SCN5A SCN8A

8.79e-04114313IPR005821
DomainIon_trans

SCN1A SCN5A SCN8A

8.79e-04114313PF00520
DomainHECT

AREL1 HUWE1

9.12e-0427312PF00632
DomainHECTc

AREL1 HUWE1

9.12e-0427312SM00119
DomainHECT_dom

AREL1 HUWE1

9.12e-0427312IPR000569
DomainHECT

AREL1 HUWE1

9.12e-0427312PS50237
DomainIQ

SCN1A SCN8A

6.17e-0371312PF00612
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SCN1A SCN5A SCN8A

1.44e-0531223M877
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

SCN1A SCN5A SCN8A

1.59e-0532223M27455
PathwayREACTOME_SMAC_XIAP_REGULATED_APOPTOTIC_RESPONSE

XIAP BIRC8

3.47e-056222MM14489
PathwayREACTOME_ACTIVATION_OF_CASPASES_THROUGH_APOPTOSOME_MEDIATED_CLEAVAGE

XIAP BIRC8

4.86e-057222MM14486
PathwayREACTOME_REGULATION_OF_PTEN_LOCALIZATION

XIAP BIRC8

1.04e-0410222MM15539
PathwayREACTOME_FORMATION_OF_APOPTOSOME

XIAP BIRC8

1.04e-0410222MM14485
PathwayREACTOME_CYTOCHROME_C_MEDIATED_APOPTOTIC_RESPONSE

XIAP BIRC8

1.52e-0412222MM14487
PathwayREACTOME_MUSCLE_CONTRACTION

DYSF SCN1A SCN5A SCN8A

2.49e-04203224M5485
PathwayBIOCARTA_BCELLSURVIVAL_PATHWAY

XIAP BIRC8

3.12e-0417222MM1353
PathwayREACTOME_APOPTOTIC_FACTOR_MEDIATED_RESPONSE

XIAP BIRC8

3.12e-0417222MM14490
PathwayBIOCARTA_MITOCHONDRIA_PATHWAY

XIAP BIRC8

4.80e-0421222MM1484
PathwayREACTOME_TNFR1_INDUCED_PROAPOPTOTIC_SIGNALING

XIAP BIRC8

5.77e-0423222MM15177
PathwayBIOCARTA_CASPASE_PATHWAY

XIAP BIRC8

6.82e-0425222MM1359
PathwayREACTOME_L1CAM_INTERACTIONS

SCN1A SCN5A SCN8A

8.43e-04121223M872
PathwayWP_DRAVET_SYNDROME

SCN1A SCN8A

8.57e-0428222M45519
PathwayREACTOME_CARDIAC_CONDUCTION

SCN1A SCN5A SCN8A

1.04e-03130223M27454
PathwayREACTOME_DEACTIVATION_OF_THE_BETA_CATENIN_TRANSACTIVATING_COMPLEX

XIAP BIRC8

1.12e-0332222MM14975
PathwayREACTOME_TNFR1_INDUCED_NF_KAPPA_B_SIGNALING_PATHWAY

XIAP BIRC8

1.19e-0333222MM15180
PathwayBIOCARTA_DEATH_PATHWAY

XIAP BIRC8

1.27e-0334222MM1422
PathwayREACTOME_RIPK1_MEDIATED_REGULATED_NECROSIS

XIAP BIRC8

1.34e-0335222MM15168
PathwayREACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS

XIAP BIRC8

1.75e-0340222MM14473
PathwayREACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS

TOP1 NUP205

2.31e-0346222M27397
PathwayREACTOME_REGULATION_OF_TNFR1_SIGNALING

XIAP BIRC8

2.41e-0347222MM15179
PathwayWP_RETT_SYNDROME

SCN1A SCN8A

2.51e-0348222M39759
PathwayPID_CASPASE_PATHWAY

XIAP TOP1

2.83e-0351222M220
PathwayREACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS

TOP1 NUP205

2.83e-0351222MM15151
Pubmed

Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes.

SCN1A SCN5A SCN8A

2.47e-08732315272007
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN1A SCN5A SCN8A

5.92e-08932316382098
Pubmed

Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

SCN1A SCN5A SCN8A

5.92e-08932315746173
Pubmed

Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals.

SCN1A SCN5A SCN8A

5.92e-08932317884088
Pubmed

Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.

SCN1A SCN5A SCN8A

1.55e-071232330175250
Pubmed

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

SCN1A SCN5A SCN8A

2.01e-071332315123669
Pubmed

Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects.

XIAP BIRC8 HUWE1

3.19e-071532330970248
Pubmed

Overexpression of the X-Linked Inhibitor of Apoptosis Protein (XIAP) in Neurons Improves Cell Survival and the Functional Outcome after Traumatic Spinal Cord Injury.

XIAP BIRC8

8.20e-07232236769152
Pubmed

Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy.

SCN1A SCN8A

8.20e-07232237901435
Pubmed

X-linked inhibitor of apoptosis deficiency in the TRAMP mouse prostate cancer model.

XIAP BIRC8

8.20e-07232218259199
Pubmed

XIAP regulates intracellular ROS by enhancing antioxidant gene expression.

XIAP BIRC8

8.20e-07232218692482
Pubmed

Deficiency of XIAP leads to sensitization for Chlamydophila pneumoniae pulmonary infection and dysregulation of innate immune response in mice.

XIAP BIRC8

8.20e-07232220427267
Pubmed

An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior.

SCN1A SCN8A

8.20e-07232226410685
Pubmed

XIAP overexpression in islet beta-cells enhances engraftment and minimizes hypoxia-reperfusion injury.

XIAP BIRC8

8.20e-07232215888033
Pubmed

The reduction of XIAP is associated with inflammasome activation in RPE: implications for AMD pathogenesis.

XIAP BIRC8

8.20e-07232231438981
Pubmed

XIAP overexpression promotes bladder cancer invasion in vitro and lung metastasis in vivo via enhancing nucleolin-mediated Rho-GDIβ mRNA stability.

XIAP BIRC8

8.20e-07232229250796
Pubmed

Genomic organization and primary characterization of miap-3: the murine homologue of human X-linked IAP.

XIAP BIRC8

8.20e-0723229205126
Pubmed

Increased X-linked inhibitor of apoptosis protein (XIAP) expression exacerbates experimental autoimmune encephalomyelitis (EAE).

XIAP BIRC8

8.20e-07232218687476
Pubmed

Lack of X-linked inhibitor of apoptosis protein leads to increased apoptosis and tissue loss following neonatal brain injury.

XIAP BIRC8

8.20e-07232219570023
Pubmed

IFN-gamma sensitizes MIN6N8 insulinoma cells to TNF-alpha-induced apoptosis by inhibiting NF-kappaB-mediated XIAP upregulation.

XIAP BIRC8

8.20e-07232216154537
Pubmed

XIAP protects oligodendrocytes against cell death in vitro but has no functional role in toxic demyelination.

XIAP BIRC8

8.20e-07232222065417
Pubmed

XIAP-deficiency leads to delayed lobuloalveolar development in the mammary gland.

XIAP BIRC8

8.20e-07232215540113
Pubmed

Inability to resolve specific infection generates innate immunodeficiency syndrome in Xiap-/- mice.

XIAP BIRC8

8.20e-07232225190756
Pubmed

Identification of an Xiap-like pseudogene on mouse chromosome 7.

XIAP BIRC8

8.20e-07232219956646
Pubmed

Deficiency in X-linked inhibitor of apoptosis protein promotes susceptibility to microbial triggers of intestinal inflammation.

XIAP BIRC8

8.20e-07232234739342
Pubmed

IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells.

XIAP BIRC8

8.20e-07232229386580
Pubmed

Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine.

SCN1A SCN5A

8.20e-07232216054936
Pubmed

Over-expression of X-linked inhibitor of apoptosis protein slows presbycusis in C57BL/6J mice.

XIAP BIRC8

8.20e-07232218755525
Pubmed

Attenuation of MPTP-induced neurotoxicity and behavioural impairment in NSE-XIAP transgenic mice.

XIAP BIRC8

8.20e-07232212667469
Pubmed

Comparative structural analysis of human Nav1.1 and Nav1.5 reveals mutational hotspots for sodium channelopathies.

SCN1A SCN5A

8.20e-07232233712547
Pubmed

Aberrant regulation of a poison exon caused by a non-coding variant in a mouse model of Scn1a-associated epileptic encephalopathy.

SCN1A SCN8A

8.20e-07232233411788
Pubmed

Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome.

SCN1A SCN8A

8.20e-07232231943325
Pubmed

Transgenic mice overexpressing XIAP in neurons show better outcome after transient cerebral ischemia.

XIAP BIRC8

8.20e-07232212812761
Pubmed

Deletion Of XIAP reduces the severity of acute pancreatitis via regulation of cell death and nuclear factor-κB activity.

XIAP BIRC8

8.20e-07232228300832
Pubmed

Role of X-linked inhibitor of apoptosis (XIAP) in frozen and thawed dormant and normal-hatched murine blastocysts.

XIAP BIRC8

8.20e-07232229605544
Pubmed

Overexpression of XIAP inhibits cisplatin-induced hair cell loss.

XIAP BIRC8

8.20e-07232235026350
Pubmed

Effects of XIAP on high fat diet-induced hepatic steatosis: a mechanism involving NLRP3 inflammasome and oxidative stress.

XIAP BIRC8

8.20e-07232231841118
Pubmed

Genomic organization of the X-linked inhibitor of apoptosis and identification of a novel testis-specific transcript.

XIAP BIRC8

8.20e-07232211597143
Pubmed

XIAP regulates cytosol-specific innate immunity to Listeria infection.

XIAP BIRC8

8.20e-07232218769721
Pubmed

XIAP inhibition of β-cell apoptosis reduces the number of islets required to restore euglycemia in a syngeneic islet transplantation model.

XIAP BIRC8

8.20e-07232221099289
Pubmed

ras Oncogene triggers up-regulation of cIAP2 and XIAP in intestinal epithelial cells: epidermal growth factor receptor-dependent and -independent mechanisms of ras-induced transformation.

XIAP BIRC8

8.20e-07232216115895
Pubmed

XIAP deficiency in hematopoietic recipient cells drives donor T-cell activation and GvHD in mice.

XIAP BIRC8

8.20e-07232230585320
Pubmed

Eliminating encephalitogenic T cells without undermining protective immunity.

XIAP BIRC8

8.20e-07232224277699
Pubmed

IAP proteins: blocking the road to death's door.

XIAP BIRC8

8.20e-07232212042762
Pubmed

Analysis of inhibitor of apoptosis protein family expression during mammary gland development.

XIAP BIRC8

8.20e-07232220584313
Pubmed

XIAP inhibits gentamicin-induced hair cell damage and ototoxicity through the caspase-3/9 pathway.

XIAP BIRC8

8.20e-07232233713642
Pubmed

Persistent Nav1.1 and Nav1.6 currents drive spinal locomotor functions through nonlinear dynamics.

SCN1A SCN8A

8.20e-07232237665666
Pubmed

Characterization of XIAP-deficient mice.

XIAP BIRC8

8.20e-07232211313486
Pubmed

XIAP Knockdown in Alcohol-Associated Liver Disease Models Exhibits Divergent in vitro and in vivo Phenotypes Owing to a Potential Zonal Inhibitory Role of SMAC.

XIAP BIRC8

8.20e-07232234025452
Pubmed

The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy.

SCN1A SCN8A

8.20e-07232217881658
Pubmed

X-linked inhibitor of apoptosis regulates T cell effector function.

XIAP BIRC8

8.20e-07232218025200
Pubmed

Inhibitor of apoptosis protein (IAP) profiling in experimental autoimmune encephalomyelitis (EAE) implicates increased XIAP in T lymphocytes.

XIAP BIRC8

8.20e-07232218055022
Pubmed

Skeletal muscle differentiation evokes endogenous XIAP to restrict the apoptotic pathway.

XIAP BIRC8

8.20e-07232219333375
Pubmed

S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease.

XIAP BIRC8

2.46e-06332219273858
Pubmed

A promotive effect for halofuginone on membrane repair and synaptotagmin-7 levels in muscle cells of dysferlin-null mice.

DYSF SYT7

2.46e-06332229771357
Pubmed

Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family.

XIAP BIRC8

2.46e-06332211390657
Pubmed

XIAP-mediated degradation of IFT88 disrupts HSC cilia to stimulate HSC activation and liver fibrosis.

XIAP BIRC8

2.46e-06332238351372
Pubmed

XIAP decreases caspase-12 cleavage and calpain activity in spinal cord of ALS transgenic mice.

XIAP BIRC8

2.46e-06332216566922
Pubmed

Quercetin ameliorates XIAP deficiency-associated hyperinflammation.

XIAP BIRC8

2.46e-06332235687753
Pubmed

XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer.

XIAP BIRC8

2.46e-06332215258565
Pubmed

Loss of XIAP facilitates switch to TNFα-induced necroptosis in mouse neutrophils.

XIAP BIRC8

2.46e-06332227735938
Pubmed

MiR-96 promotes myocardial infarction-induced apoptosis by targeting XIAP.

XIAP BIRC8

2.46e-06332233752931
Pubmed

Anti-apoptotic protein BRE/BRCC45 attenuates apoptosis through maintaining the expression of caspase inhibitor XIAP in mouse Lewis lung carcinoma D122 cells.

XIAP BIRC8

2.46e-06332224395041
Pubmed

The X-linked inhibitor of apoptosis regulates long-term depression and learning rate.

XIAP BIRC8

2.46e-06332227189977
Pubmed

Phenotypic differences between mice deficient in XIAP and SAP, two factors targeted in X-linked lymphoproliferative syndrome (XLP).

XIAP BIRC8

2.46e-06332219595300
Pubmed

Intact Regulatory T-Cell Function but Defective Generation of IL-17A-Producing CD4+ T Cells in XIAP Deficiency.

XIAP BIRC8

2.46e-06332226825770
Pubmed

Interaction of checkpoint kinase 1 and the X-linked inhibitor of apoptosis during mitosis.

XIAP BIRC8

2.46e-06332214759516
Pubmed

Variable patterns of mutation density among NaV1.1, NaV1.2 and NaV1.6 point to channel-specific functional differences associated with childhood epilepsy.

SCN1A SCN8A

2.46e-06332232845893
Pubmed

miR-23a regulation of X-linked inhibitor of apoptosis (XIAP) contributes to sex differences in the response to cerebral ischemia.

XIAP BIRC8

2.46e-06332221709246
Pubmed

Inhibitor of apoptosis proteins are required for effective fusion of autophagosomes with lysosomes.

XIAP BIRC8

2.46e-06332229743550
Pubmed

Subcellular localization of a promoter and an inhibitor of apoptosis (Smac/DIABLO and XIAP) during brain ischemia/reperfusion.

XIAP BIRC8

2.46e-06332212395105
Pubmed

Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy.

SCN1A SCN8A

2.46e-06332228518218
Pubmed

FAIM-L regulation of XIAP degradation modulates Synaptic Long-Term Depression and Axon Degeneration.

XIAP BIRC8

2.46e-06332227767058
Pubmed

Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance.

SCN1A SCN8A

2.46e-06332224704313
Pubmed

The Sept4 septin locus is required for sperm terminal differentiation in mice.

XIAP BIRC8

2.46e-06332215737931
Pubmed

The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels.

SCN1A SCN8A

2.46e-06332228117367
Pubmed

X-linked inhibitor of apoptosis protein negatively regulates neuronal differentiation through interaction with cRAF and Trk.

XIAP BIRC8

2.46e-06332223928917
Pubmed

Involvement of the Edar signaling in the control of hair follicle involution (catagen).

XIAP BIRC8

2.46e-06332217148670
Pubmed

Caspase-3 Regulates YAP-Dependent Cell Proliferation and Organ Size.

XIAP BIRC8

2.46e-06332229775577
Pubmed

Interaction between XIAP and Smac/DIABLO in the mouse brain after transient focal cerebral ischemia.

XIAP BIRC8

2.46e-06332212973017
Pubmed

Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy.

SCN1A SCN8A

2.46e-06332217928448
Pubmed

Inhibitors of apoptosis proteins (IAPs) are required for effective T-cell expansion/survival during antiviral immunity in mice.

XIAP BIRC8

2.46e-06332224335231
Pubmed

Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progression.

XIAP BIRC8

2.46e-06332224422988
Pubmed

Sept4/ARTS is required for stem cell apoptosis and tumor suppression.

XIAP BIRC8

2.46e-06332220952537
Pubmed

Human Nav1.6 Channels Generate Larger Resurgent Currents than Human Nav1.1 Channels, but the Navβ4 Peptide Does Not Protect Either Isoform from Use-Dependent Reduction.

SCN1A SCN8A

2.46e-06332226182346
Pubmed

De novo SCN1A, SCN8A, and CLCN2 mutations in childhood absence epilepsy.

SCN1A SCN8A

2.46e-06332231054517
Pubmed

IAP regulation of metastasis.

XIAP BIRC8

2.46e-06332220129247
Pubmed

The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function.

HUWE1 CHD5 SCN8A

3.79e-063332322357600
Pubmed

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.

SCN1A SCN8A

4.92e-06432217537961
Pubmed

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.

SCN1A SCN8A

4.92e-06432235031483
Pubmed

Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.

SCN1A SCN8A

4.92e-06432229578003
Pubmed

X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization.

XIAP BIRC8

4.92e-06432219473982
Pubmed

Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo.

XIAP BIRC8

4.92e-06432215798218
Pubmed

Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus.

SCN1A SCN8A

4.92e-06432221156207
Pubmed

Sept4/ARTS regulates stem cell apoptosis and skin regeneration.

XIAP BIRC8

4.92e-06432223788729
Pubmed

Enteroendocrine Progenitor Cell-Enriched miR-7 Regulates Intestinal Epithelial Proliferation in an Xiap-Dependent Manner.

XIAP BIRC8

4.92e-06432231756561
Pubmed

X-Linked inhibitor of apoptosis protein is involved in mutant SOD1-mediated neuronal degeneration.

XIAP BIRC8

4.92e-06432212153481
Pubmed

X-linked inhibitor of apoptosis (XIAP) protein protects against caspase activation and tissue loss after neonatal hypoxia-ischemia.

XIAP BIRC8

4.92e-06432215207275
Pubmed

Unique anti-apoptotic activity of EAAC1 in injured motor neurons.

XIAP BIRC8

4.92e-06432216858406
Pubmed

Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML.

XIAP BIRC8

4.92e-06432219897582
InteractionSCN11A interactions

SCN1A SCN5A SCN8A

1.34e-0615303int:SCN11A
GeneFamilySodium voltage-gated channel alpha subunits

SCN1A SCN5A SCN8A

1.95e-0792531203
GeneFamilyRing finger proteins|Baculoviral IAP repeat containing|Caspase recruitment domain containing

XIAP BIRC8

5.11e-058252419
CoexpressionGSE17301_CTRL_VS_48H_ACD3_ACD28_STIM_CD8_TCELL_UP

IGFLR1 GTDC1 DYSF MGAT4A SCN5A

4.19e-06200325M8045
ToppCellwk_15-18-Epithelial-PNS-Schwann_precursor|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

GRID2 SACS SCN1A SCN5A SCN8A

1.65e-071773255357359e6c2161a37f39a6b3b78449f5cbc327d1
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-Differentiating_glia|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL2A1 ADGB GRID2 SCN5A

5.65e-0616432457301178e420983c0cb72178e288a3a0449fdda3
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SYK ADGB DYSF HLA-DQA1

5.93e-0616632463dc58864268b4e7779e4c45155022556fc634f9
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL2A1 DYSF SACS SCN8A

7.30e-061753248b498eea1ec1c1f27b171025c3d08adf3687bafc
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte-Chondrocyte_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL2A1 DYSF SACS SCN8A

7.30e-06175324a5db428b078938627e61b7e944c1e0c1d61ac2da
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYT7 SCN1A CHD5 SCN8A

9.29e-061863247278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYT7 SCN1A CHD5 SCN8A

1.07e-05193324be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYT7 SCN1A CHD5 SCN8A

1.07e-051933240c652ebe22ce5d2927599dd97ef1920547858395
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYT7 SCN1A CHD5 SCN8A

1.07e-051933248689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SYK OSBPL11 GRID2 HLA-DQA1

1.21e-051993245b6feacb0ca92c3fc6b327be978320426dcf6f68
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.6.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SYK OSBPL11 GRID2 HLA-DQA1

1.21e-05199324fde8e3ba19d19069a4d3b8db55bfe6220cf634d5
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SACS ALOX15B ISM1

1.88e-04156323abf9dd075b1ca8f613c660cc82f8a5af071fb6ab
ToppCellCOVID-19-Myeloid-Dendritic_cells|COVID-19 / group, cell type (main and fine annotations)

SYK HLA-DQA1 MGAT4A

1.88e-04156323a07a9096799e4ba663841c70035b4b32c1fda4f9
ToppCellPND03-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HLA-DQA1 CHD5 ALOX15B

1.88e-04156323af47a4b17342bdb3cb62d7e2d52a81168e588629
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SACS ALOX15B ISM1

1.88e-04156323dd41ed918b07fa248da458a629b3c53cb7ea8764
ToppCellfacs-Limb_Muscle-Muscle_Diaphragm-18m-Lymphocytic-B_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK SYT7 HLA-DQA1

1.99e-04159323656aa20706bdba81bbcc3e68e6058215b92b8802
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-5|TCGA-Stomach / Sample_Type by Project: Shred V9

COL2A1 SYT7 SCN5A

1.99e-04159323c40fe552da3abdb1df87e9e1647468dc038bec0a
ToppCelldroplet-Bladder-nan-3m-Hematologic-macrophage|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK ADGB HLA-DQA1

2.10e-041623230cee9ef405765f3f82d0cd7b8adc88f6e9fdbb5c
ToppCell367C-Epithelial_cells-Epithelial-A_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

IGFLR1 SCN1A ALOX15B

2.18e-04164323b0ed8cb6000ce8bf94444307e4b7b3574fa3fab2
ToppCell367C-Epithelial_cells-Epithelial-A_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

IGFLR1 SCN1A ALOX15B

2.18e-041643233aea6207a011ad55a1aeb2ed9fb54d31b23694b5
ToppCelldroplet-Trachea-3m-Hematologic-myeloid-granulocyte-granulocyte_l34|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SYK HLA-DQA1 SCN8A

2.34e-0416832384977db9d71e59208727885320cc18d80d064380
ToppCell5'-Adult-SmallIntestine-Hematopoietic-Myeloid-cDC1|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DYSF HLA-DQA1 SCN5A

2.38e-04169323da3485d77bb7876fad4f166f6099e681b27457ae
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.6.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SYK HLA-DQA1 MGAT4A

2.43e-04170323e0429f45a3639a10294ceb492f2286c495481c2b
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-conventional_dendritic_cell-DC1_(conventional_dendritic_cell)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SYK DYSF HLA-DQA1

2.47e-041713231018d7bd378ce20bee56a77d5851b3538c55098c
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-conventional_dendritic_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SYK DYSF HLA-DQA1

2.47e-04171323173bb5318fdbaef6e695b6f9e3e0ff4a5432a1a4
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-conventional_dendritic_cell-DC1_(conventional_dendritic_cell)-DC1_L.1.2.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SYK DYSF HLA-DQA1

2.47e-041713236bda333bb751d7835a04f21ac959eea79f2516aa
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_B-B_atypical-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

SYK IGFLR1 HLA-DQA1

2.55e-0417332323248019c819f6e38337dcc4edb763ef1992e89e
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_B-B_atypical|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

SYK IGFLR1 HLA-DQA1

2.55e-04173323f135cc9dcf34f33ced3210171ab40ae6d77cfae0
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GRID2 CHD5 SCN5A

2.64e-04175323d52794426f2703a80e91ae0a8ff2d8e0ce4aa4a8
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GRID2 CHD5 SCN5A

2.64e-04175323454f03e6109d65f5db08dbb41ecc19ffb6bbc4e0
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Rectal_Adenocarcinoma-7|TCGA-Colorectal / Sample_Type by Project: Shred V9

SYT7 TOP1 ISM1

2.78e-04178323edc76b8f15056ec1c9a1c61a048b6331a92592d6
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYK CCNK HLA-DQA1

2.82e-0417932330efe1f0394c0edb27b91890b5c4637b73cbc5ec
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

SYK OSBPL11 TOP1

2.87e-04180323310a311c3ed924c912a800cf287a825de44b8775
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SYK IGFLR1 HLA-DQA1

2.91e-041813230bc58c8942491e7ee5b858c5742770df7677532f
ToppCellPCW_07-8.5-Neuronal-Neuronal_SCP-neuro_pre_proliferating_SCP_(4)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

COL2A1 GRID2 SCN1A

2.96e-04182323bfb725fff3d20066d8ac0a6ba2f88498fcbd876e
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Myeloid-Monocytic-Nonclassical_Monocyte-Mono_c4-CD14-CD16|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

SYK HLA-DQA1 ALOX15B

3.01e-04183323745271bfe15e94a58157cd97d771e610f964341b
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-Zbtb32+_B_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SYK HLA-DQA1 MGAT4A

3.11e-041853235fd4a3776259c96cf2dcb87f050af8226acbbda9
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-Zbtb32+_B_cell-Zbtb32+_B_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SYK HLA-DQA1 MGAT4A

3.11e-041853234c55fa96877ab9a00fcbec3fb70fd2208d222527
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic-dendritic_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGFLR1 HLA-DQA1 SCN5A

3.16e-0418632375b1f342be5d6dbe0e7acd924a0ca75964f6bab0
ToppCell5'-GW_trimst-2-LymphNode-Hematopoietic-B_cells-Immature_B|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SYK IGFLR1 HLA-DQA1

3.16e-04186323459a7e97bbac2b2cd253aa4ab38d0e4ae6191e8b
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs-|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGFLR1 HLA-DQA1 SCN5A

3.16e-041863230c3d195077de7b4c354c127a26116438aef29244
ToppCell5'-Airway_Nasal-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGFLR1 HLA-DQA1 SCN5A

3.16e-04186323a558fd00053e7dd6216b01dc8e650c30cee451f1
ToppCellPCW_07-8.5-Neuronal-Neuronal_SCP-neuro_proliferating_SCP1_(1)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

COL2A1 GRID2 SCN1A

3.16e-041863233113c85d0ac5fc46532c19b1bb71f34b985e1276
ToppCell3'_v3-GI_small-bowel-Myeloid_Mac-Erythrophagocytic_macrophages|GI_small-bowel / Manually curated celltypes from each tissue

SYK HLA-DQA1 ALOX15B

3.16e-04186323a0cc925af97e47efd0c9bc17c37963e8ad4e5b35
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYT7 SCN1A SCN8A

3.26e-041883231efbc99bcd6542e5d9fa91edb7c4295167914786
ToppCellChildren_(3_yrs)-Immune-alveolar_macrophage_(MARCO_positive)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

SYK OSBPL11 HLA-DQA1

3.26e-04188323d7a9fb5b021e127b8d927658a55a71098d513b5c
ToppCell(7)_DC_1|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

ADGB DYSF HLA-DQA1

3.26e-04188323832887afa4a54ed80906bc02176d646529c13398
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_B-B_atypical-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

SYK IGFLR1 HLA-DQA1

3.26e-04188323ef05d2fb17fd427d46d454e67073e0e1b45bb24c
ToppCell5'-Adult-Distal_Rectal-Hematopoietic-Myeloid-LYVE1+_Macrophage|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HLA-DQA1 ALOX15B SCN8A

3.31e-041893239e3c083174a64ea78648c6d48498fc4e721b569f
ToppCell3'-Adult-LargeIntestine-Hematopoietic-Myeloid-Macrophages|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGFLR1 HLA-DQA1 ALOX15B

3.31e-04189323b491204cf38dc80a2583e3082a82dda8d77b3fc4
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_B-B_atypical|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

SYK IGFLR1 HLA-DQA1

3.31e-04189323ebaf722738c71d5f33f72341f801c6880f4aee14
ToppCell5'-Adult-Distal_Rectal-Hematopoietic-Myeloid|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HLA-DQA1 ALOX15B SCN8A

3.31e-041893236e19bfa52406ebe095daa99f958ec4d596ce6e39
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYT7 SCN1A SCN8A

3.31e-04189323f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCell3'_v3-Lung-Myeloid_Dendritic-DC2|Lung / Manually curated celltypes from each tissue

ADGB IGFLR1 HLA-DQA1

3.36e-04190323468525c05e38158a3b8a445882b2d63dfb1d2c63
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-6|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SYK IGFLR1 HLA-DQA1

3.41e-041913236a8b0987e75456a257954288206da0032605ff2a
ToppCellAdult-Immune-alveolar_macrophage_(MARCO_positive)-D122|Adult / Lineage, Cell type, age group and donor

SYK OSBPL11 GTDC1

3.52e-04193323cc1b6d3bf56e4a88f6fe23dd036a83cf5538c958
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SYK HLA-DQA1 ALOX15B

3.52e-041933239fd2bc726bddf414f3de1c7a5ffd9317d3c98e29
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SYT7 SCN1A SCN8A

3.52e-041933235fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCellcellseq-Immune-Immune_Myeloid-Myeloid_Dendritic|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SYK IGFLR1 HLA-DQA1

3.57e-0419432374d588de2f84a4ef112fd642f7e112a542d5ef11
ToppCellcellseq-Immune-Immune_Myeloid-Myeloid_Dendritic-cDC2|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SYK IGFLR1 HLA-DQA1

3.57e-04194323024568d8a862f0fe4da1f66a58c6e71f0e8279f3
ToppCellMonocytes-C1QA+_Monocytes|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

SYK DYSF HLA-DQA1

3.57e-041943233e104e85574894c04791252d466d438fc809dde3
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

IGFLR1 SACS HLA-DQA1

3.62e-04195323a4d36654b968acb1aea252ac203683939461f1d1
ToppCellwk_15-18-Hematologic-Myeloid-DC2|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

SYK IGFLR1 HLA-DQA1

3.62e-04195323143093edefb3da63bb10adb1f5ea6e250a524ac2
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

IGFLR1 SACS HLA-DQA1

3.62e-04195323cd811abd949ef201aef1c8515da5575ab1b1cfea
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Dendritic|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SYK IGFLR1 HLA-DQA1

3.62e-041953237dd0cb8f3753fe761fac200cbd161708b6528c51
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SYK IGFLR1 HLA-DQA1

3.62e-041953239cfbdb528088ad0ab100c7431c7d8f140a846de8
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell-DC2_(CD1c+_dendritic_cell)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SYK IGFLR1 HLA-DQA1

3.62e-0419532366f3b3e15eaa21bc7cf2f204cac81de1a160a748
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell-DC2_(CD1c+_dendritic_cell)-DC2_L.1.2.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SYK IGFLR1 HLA-DQA1

3.62e-04195323bbf5f79be4fcea754328f1af7ee5625075248100
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

IGFLR1 SACS HLA-DQA1

3.68e-04196323fd756b247b2d8a291e8e71bec6f1e463d6557536
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SYT7 SCN1A CHD5

3.68e-04196323379132e944be2b9dcdf1a787293a48313956902c
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SYK HLA-DQA1 ALOX15B

3.73e-04197323dea1d29154c585ab588e50b83c7c8de7fe24d2d4
ToppCellCOVID-granulo1-|COVID / Condition, Cell_class and T cell subcluster

SYK DYSF HLA-DQA1

3.73e-04197323190392117dc6269a21983bd3e554066fd48acd5e
ToppCellCOVID-granulo1|COVID / Condition, Cell_class and T cell subcluster

SYK DYSF HLA-DQA1

3.73e-041973234cd774d9d5a6bf7729dc6b7bcd3ddfe3f3051ada
ToppCellTCGA-Skin-Metastatic-Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

L3MBTL3 TOP1 MGAT4A

3.79e-04198323af4fb9eb2295c7b90624b38ba25619aa15254efa
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SCN1A CHD5 SCN8A

3.79e-04198323c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SYK HLA-DQA1 MGAT4A

3.79e-0419832300a54af5267bfe0eeab6720bf890dc4b6b803bfd
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

L3MBTL3 TOP1 MGAT4A

3.79e-0419832362cbf4b29e8af4983fb47a17f96da62682a5137e
ToppCellFetal_29-31_weeks-Immune|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SYK HLA-DQA1 MGAT4A

3.79e-041983235dff131356b8c22743bd27b2b21f86ee6e4a0a0d
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SCN1A CHD5 SCN8A

3.79e-041983236d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SCN1A CHD5 SCN8A

3.79e-041983238ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCellParenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_CHIT1|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SYK HLA-DQA1 ALOX15B

3.79e-04198323243109377d62d20c69e9d1fedc252156e90cda1e
ToppCellTCGA-Skin-Metastatic|TCGA-Skin / Sample_Type by Project: Shred V9

L3MBTL3 TOP1 MGAT4A

3.79e-04198323ad39cce004867f083f8da1954e0cf5a263815184
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SCN1A CHD5 SCN8A

3.79e-041983234ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellMS-IIF-Myeloid-pDC|IIF / Disease, condition lineage and cell class

SYK IGFLR1 HLA-DQA1

3.85e-04199323e262ee854e64d87460bee810c14d6cbe744460e8
ToppCellTracheal-10x3prime_v2-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SYK HLA-DQA1 ALOX15B

3.85e-041993237648860058eec66019b574ad840d6f5cfa4476d9
ToppCellcellseq-Immune-Immune_Myeloid-IM|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SYK IGFLR1 HLA-DQA1

3.85e-04199323b3267d5a7ae0461f5e9e6a3ab6783317a8c42506
ToppCellTracheal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_CHIT1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SYK HLA-DQA1 ALOX15B

3.85e-041993236ce7612ee2ae211eb0f73391e96089ad5431c537
ToppCellcellseq-Immune-Immune_Myeloid-IM-IM|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SYK IGFLR1 HLA-DQA1

3.85e-0419932301dacee8bb392639d475be3cb27ba3eeff1e57f1
ToppCellParenchyma_Control_(B.)-Immune-TX-TRAM-2|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

SYK OSBPL11 HLA-DQA1

3.90e-042003237c56935446f10d202eafa1f9ee7cb0aae4c2607e
ToppCellHematolymphoid-Microglia|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SYK GRID2 MGAT4A

3.90e-0420032321bcca3b670fe9bac034aef2275d3de4a9a73e2b
ToppCellTracheal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macrophage_intravascular|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SYK HLA-DQA1 ALOX15B

3.90e-04200323c210b98a75ab5d899d7278bc9b577f76a0b3970c
ToppCellParenchyma_COVID-19-Immune-TX-MoAM-2|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

SYK HLA-DQA1 MGAT4A

3.90e-0420032333c5615cbedb9e14f4433169babd3a3a51f69b4c
ToppCellHematolymphoid-Microglia-TYROBP----L1-3|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SYK GRID2 MGAT4A

3.90e-04200323a20dce14f94777687aad57d6fbe3258ad376f63f
ToppCellTracheal-10x3prime_v2-Immune_Myeloid-Macrophage_other|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SYK HLA-DQA1 ALOX15B

3.90e-042003233cfb28299a55fc1c150262a7333c59a48ae65ad1
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SYK OSBPL11 HLA-DQA1

3.90e-04200323a443e475e7a10c26a6173d1af961de6219e0e567
ToppCellParenchymal-10x5prime-Immune_Myeloid-Dendritic_cell-DC_2|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SYK IGFLR1 HLA-DQA1

3.90e-04200323f0e7c2f07a7065511bf0b6521ce2e74e04e48544
ToppCellHematolymphoid-Microglia-TYROBP--|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SYK GRID2 MGAT4A

3.90e-04200323dc344b3ec51d506952e38f0b3a7795d65f9dd4eb
ToppCellHematolymphoid-Microglia-TYROBP---|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SYK GRID2 MGAT4A

3.90e-04200323a8646d0fca99f10827c2d2a12e584660ef7155f1
ToppCellHematolymphoid-Microglia-TYROBP-|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SYK GRID2 MGAT4A

3.90e-042003233bba5219453322198e8fdb0921d5f8c403598751
ToppCellHematolymphoid-Microglia-TYROBP|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic

SYK GRID2 MGAT4A

3.90e-0420032333036d21c1c82109284473a515c4f890b33fdd5c
DrugPhenytoin

SCN1A SCN5A

1.91e-062322DB00252
DrugWy-41,770

COL2A1 ALOX15B

5.74e-063322CID000165241
Drugbendamustine

XIAP BIRC8 TOP1

1.90e-0537323CID000065628
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN1A SCN5A SCN8A

1.02e-0710293DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN1A SCN5A SCN8A

1.02e-0710293DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN1A SCN5A SCN8A

1.87e-0712293DOID:0060170 (implicated_via_orthology)
Diseasecathepsin L1 measurement

ADGB HLA-DQA1

1.11e-0416292EFO_0010619
Diseasesphingomyelin measurement

COL2A1 HLA-DQA1 ISM1 SCN8A

1.52e-04278294EFO_0010118
Diseaseesterified cholesterol measurement

SYT7 HLA-DQA1 TOP1

2.68e-04128293EFO_0008589
Diseaseneuroimaging measurement

COL2A1 CDC5L GTDC1 DYSF L3MBTL3 HLA-DQA1

5.18e-041069296EFO_0004346
Diseaseepilepsy (implicated_via_orthology)

SCN1A SCN5A SCN8A

5.44e-04163293DOID:1826 (implicated_via_orthology)
Diseasehuman papilloma virus infection, oral cavity cancer

DYSF HLA-DQA1

7.84e-0442292EFO_0001668, EFO_0005570

Protein segments in the cluster

PeptideGeneStartEntry
CKARWYEWLDPSIKK

CDC5L

46

Q99459
LIKWKDLPYDQCTWE

CHD5

611

Q8TDI0
WKPWEHIYSLCKAVK

ADGB

171

Q8N7X0
NLDHTKPCWYWDKKD

CCNK

16

O75909
KPCWYWDKKDLAHTP

CCNK

21

O75909
VWKRWKHLDPACAAD

LINC00313

36

P59037
YDCKVEHWGLDKPLL

HLA-DQA1

186

P01909
LKLCHPEWKSGDYWI

COL2A1

1286

P02458
ASLWGPYKDIWHKVG

NUP205

11

Q92621
PKGKKAWCWASYLEE

L3MBTL3

226

Q96JM7
HGWYGWVKKELEKIP

RBBP9

21

O75884
YKEKPIDWLLDHILW

MGAT4A

316

Q9UM21
HGKWPVKWYAPECIN

SYK

531

P43405
KHKWWPKNGQCDLYS

GRID2

801

O43424
PLWRRHCKKYWLISE

FBXO3

51

Q9UK99
IKTWNIGKCELYHWV

HUWE1

41

Q7Z6Z7
WEQHAKWYPGCKYLL

BIRC8

56

Q96P09
FILLWHLCWPKEKAD

IGFLR1

181

Q9H665
KVSWDWKDPYEVGHS

AREL1

61

O15033
GDCVVYTLPAKKWHW

GTDC1

26

Q4AE62
IYKLWPEASKVKVHW

SACS

531

Q9NZJ4
WAGDWFVCPEKTLLH

DYSF

926

O75923
YKVDVLPWIICKGDW

ISM1

416

B1AKI9
EGDGWVYHKPLWKII

OSBPL11

726

Q9BXB4
WKAYNPGWPHCLDEK

ALOX15B

151

O15296
YLSWKSGPGEVKHWK

SYT7

371

O43581
APGKVWWRLRKTCYH

SCN5A

1186

Q14524
LIWDCSPYWLKVKHV

SCN1A

746

P35498
PWEQHAKWYPGCKYL

XIAP

316

P98170
LIWECHPYWIKLKEI

SCN8A

731

Q9UQD0
TEWLPHSWLQCKALY

TAMM41

326

Q96BW9
AWCKKWGVPIEKIYN

TOP1

731

P11387
KHFFPKWLQVLCSWL

TFIP11

656

Q9UBB9