Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessresponse to carbon dioxide

SLC4A1 KCNJ16

2.11e-056252GO:0010037
GeneOntologyCellularComponentbasolateral plasma membrane

NKD2 TJP1 SLC4A1 KCNJ16

5.29e-04320254GO:0016323
GeneOntologyCellularComponentcell-cell junction

HMCN1 TCHP TJP1 CLDN17 SLC4A1

5.90e-04591255GO:0005911
GeneOntologyCellularComponentbasal plasma membrane

NKD2 TJP1 SLC4A1 KCNJ16

7.72e-04354254GO:0009925
GeneOntologyCellularComponentcell cortex

ACTR1A HMCN1 TCHP SLC4A1

9.19e-04371254GO:0005938
GeneOntologyCellularComponentbasal part of cell

NKD2 TJP1 SLC4A1 KCNJ16

9.85e-04378254GO:0045178
Pubmed

The interaction and colocalization of Sam68 with the splicing-associated factor YT521-B in nuclear dots is regulated by the Src family kinase p59(fyn).

KHDRBS1 YTHDC1

1.49e-06325210564280
Pubmed

The STAR/GSG family protein rSLM-2 regulates the selection of alternative splice sites.

KHDRBS1 YTHDC1

1.04e-05725211118435
Pubmed

Cerebrospinal fluid-derived Semaphorin3B orients neuroepithelial cell divisions in the apicobasal axis.

DPYSL2 TJP1

4.49e-051425225721514
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

ACTR1A DPYSL2 KHDRBS1 ABLIM3 TJP1 INPP4A SLC4A1

4.92e-05143125737142655
Pubmed

The human (PEDB) and mouse (mPEDB) Prostate Expression Databases.

BPTF YTHDC1 LYRM1

6.03e-0510625311752298
Pubmed

GRHL2 Is Required for Collecting Duct Epithelial Barrier Function and Renal Osmoregulation.

TJP1 SLC4A1

6.70e-051725229237740
Pubmed

Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function.

TJP1 CLDN17

8.42e-051925222155109
Pubmed

Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.

KIF14 ACTR1A MAP3K13 KHDRBS1 ABLIM3

1.53e-0473225534732716
Pubmed

Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation.

TJP1 CLDN17

1.60e-042625222275141
Pubmed

A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.

ACTR1A BPTF YTHDC1 TJP1 CLDN17

2.12e-0478625529128334
Pubmed

Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.

KIF14 TCHP TJP1

2.40e-0416925331462741
Pubmed

WNT/RYK signaling restricts goblet cell differentiation during lung development and repair.

FOXA3 TJP1

4.20e-044225231776260
Pubmed

Claudin-9 constitutes tight junctions of folliculo-stellate cells in the anterior pituitary gland.

TJP1 CLDN17

4.40e-044325234737342
Pubmed

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.

DPYSL2 SPRED2 YTHDC1 TCHP ABLIM3 ZNF329

5.13e-04147725631515488
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

ACTR1A DPYSL2 ABLIM3 TJP1 KCNJ16

5.40e-0496325528671696
Pubmed

Proteomic and yeast 2-hybrid screens to identify PTEN binding partners.

KIF14 KHDRBS1 TJP1

5.60e-0422625337839992
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

KIF14 BPTF DPYSL2 TJP1

5.97e-0454925438280479
Pubmed

Dynamin-1 co-associates with native mouse brain BKCa channels: proteomics analysis of synaptic protein complexes.

ACTR1A KHDRBS1

6.43e-045225220114047
InteractionCORO1A interactions

KIF14 YTHDC1 FOXA3 TMEM205 TJP1

7.68e-07142255int:CORO1A
InteractionSPATA13 interactions

KIF14 KHDRBS1 YTHDC1

2.21e-0621253int:SPATA13
InteractionRALY interactions

KIF14 BPTF KHDRBS1 YTHDC1 FOXA3 RIOK2

3.88e-06356256int:RALY
InteractionZDHHC6 interactions

KHDRBS1 YTHDC1 CLDN17

6.08e-0562253int:ZDHHC6
InteractionNIN interactions

KIF14 ACTR1A DPYSL2 TCHP TJP1

6.91e-05359255int:NIN
InteractionPRDM16 interactions

ACTR1A KHDRBS1 RIOK2 TCHP

9.17e-05195254int:PRDM16
InteractionTNFAIP1 interactions

KIF14 YTHDC1 DAPP1

1.03e-0474253int:TNFAIP1
Cytoband17q24.3

BPTF KCNJ16

3.85e-051725217q24.3
CytobandEnsembl 112 genes in cytogenetic band chr17q24

BPTF KCNJ16

1.31e-0398252chr17q24
CytobandEnsembl 112 genes in cytogenetic band chr1q25

COLGALT2 HMCN1

3.73e-03167252chr1q25
CoexpressionLEE_AGING_CEREBELLUM_DN

ACTR1A DPYSL2 SLC4A1

4.56e-0573253M1544
CoexpressionLEE_AGING_CEREBELLUM_DN

ACTR1A DPYSL2 SLC4A1

4.95e-0575253MM662
ToppCellTCGA-Head_and_Esophagus-Primary_Tumor-Head_and_Neck_Carcinoma-Squamous_Cell_Carcinoma-5|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9

MAP3K13 YTHDC1 TCHP DAPP1

1.21e-0614425476c0e551864c4faab7528c4ecf1a40d7ea60569f
ToppCell367C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

DPYSL2 NKD2 HMCN1 ABLIM3

4.11e-061962546730743cf088c419ccc2d28765769fc09d3ba6a7
ToppCell367C-Fibroblasts-Fibroblast-C_(Myofibroblast)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

DPYSL2 NKD2 HMCN1 ABLIM3

4.11e-0619625421dab89f3699037138a9c7a0e4dc98739a9fad9c
ToppCellLPS-IL1RA-Myeloid-Monocytes,_Macrophages-Erythroid|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

COLGALT2 SLC4A1 DAPP1

7.01e-051442537c471e332f87d60f4dbed01f3e66bf39995218d0
ToppCellClub-club-12|World / Class top

FOXA3 SLC4A1 KCNJ16

1.05e-041652539b7a31cbdcd2f96b8bd08a4cd4141b92bd5e9062
ToppCellfacs-GAT-Fat-18m-Endothelial-endothelial_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABLIM3 TJP1 SLC4A1

1.34e-04179253e0542694fa79d67f67be6f85b4fa6d18f7523253
ToppCellfacs-GAT-Fat-18m-Endothelial-nan|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABLIM3 TJP1 SLC4A1

1.34e-0417925383343b68977969c7978acd930a66fc7c44df6a15
ToppCellfacs-GAT-Fat-18m-Endothelial|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABLIM3 TJP1 SLC4A1

1.34e-04179253d56fa2a0b119d51a8d41b00fbbd7dfddefeb279c
ToppCell3'_v3-bone_marrow-Myeloid_Dendritic-DC2|bone_marrow / Manually curated celltypes from each tissue

DPYSL2 KCNJ16 DAPP1

1.43e-04183253f482e4fe011fa450a475034b1e25587233855bdb
ToppCell10x5'v1-week_12-13-Endothelial-stroma-sinusoidal_EC|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

HMCN1 ABLIM3 TJP1

1.50e-04186253e8ead5634686ebaa6a230eea69795d923ce9939d
ToppCellnormal_Lung-Myeloid_cells-Activated_DCs|normal_Lung / Location, Cell class and cell subclass

MAP3K13 SPRED2 DAPP1

1.50e-041862530987c9a39503eb6c75a2bf4db98b2b2fd46956fb
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D175|Adult / Lineage, Cell type, age group and donor

COLGALT2 NKD2 HMCN1

1.52e-04187253e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCellBAL-Severe-Myeloid-cDC-cDC-cDC_10|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

MAP3K13 SPRED2 DAPP1

1.67e-04193253a2194012dfa0174c6160900625c44e0fd04c50e7
ToppCellfacs-Large_Intestine-Distal-24m-Epithelial-secretory_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPYSL2 PXYLP1 FOXA3

1.67e-0419325364bcdbb422f8da6fc3275e82f6aaf562f546a180
ToppCellBAL-Severe-Myeloid-cDC-cDC-cDC_10|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MAP3K13 SPRED2 DAPP1

1.67e-041932537426a30ed01e5c8376b3e0ebe0f1057cfee88340
ToppCellMesenchymal-matrix_fibroblast_1_cell|World / Lineage, Cell type, age group and donor

NKD2 HMCN1 ABLIM3

1.67e-04193253acad568621ed677031797b8c2e34dafea798d681
ToppCellfacs-Large_Intestine-Distal-24m-Epithelial-Reg4/cKit+_deep_crypt_secretory_cells_(Distal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPYSL2 PXYLP1 FOXA3

1.67e-041932535a92697430f16c49e19a5f727d289d7bd1ece31c
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

NKD2 HMCN1 ABLIM3

1.67e-0419325399525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCelldroplet-Lung-21m-Endothelial-capillary_endothelial|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DPYSL2 HMCN1 TJP1

1.69e-041942530d72cb6183062d48488c73320e48044d070fbcac
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NKD2 HMCN1 ABLIM3

1.69e-0419425335f132cc38ac133be01834ed0946188aa0757eb4
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NKD2 HMCN1 ABLIM3

1.69e-04194253011e14d9ed1393275f892060e7708ffadcd0767f
ToppCelldroplet-Lung-21m-Endothelial-capillary_endothelial-capillary_endothelial_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DPYSL2 HMCN1 TJP1

1.69e-041942531a637809c0ec97374839c3476527e87eea75ed20
ToppCellILEUM-inflamed-(3)_mature_DC|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

DPYSL2 MAP3K13 DAPP1

1.69e-04194253369bbf4e8e2d674e5a51a614b52b97d05d3ab9c7
ToppCellfacs-Thymus-Thymus_Epithelium|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NKD2 HMCN1 TJP1

1.74e-041962536bc1187dfc4860a4e09032d7ea87ba3d9fe9f363
ToppCellfacs-Thymus-Thymus_Epithelium-18m|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NKD2 HMCN1 TJP1

1.74e-04196253c8c89e469402e11aa2a9561e859b6fd1fb66c39b
ToppCellBAL-Mild-cDC_10|Mild / Compartment, Disease Groups and Clusters

MAP3K13 SPRED2 DAPP1

1.77e-04197253c0550d41dd5619b369b590f3d6a61154dd7b2cab
ToppCellCOVID-19-Myeloid-Migratory_DC|COVID-19 / Condition, Lineage and Cell class

MAP3K13 SPRED2 DAPP1

1.77e-04197253b6d6cdae33753c1e38394f1f879e00b87f9c0496
ToppCellIPF-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

NKD2 HMCN1 ABLIM3

1.77e-04197253f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NKD2 HMCN1 TJP1

1.82e-04199253eeb7d370d4dfacf705306c72ccc4919ddefacff1
ToppCellBAL-Severe-cDC_10|Severe / Compartment, Disease Groups and Clusters

MAP3K13 SPRED2 DAPP1

1.82e-0419925354bdadd04abaf8caa948b0177c037bc089ca07e6
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

BPTF HMCN1 TJP1

1.85e-04200253dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell390C-Fibroblasts-Fibroblast-H-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

DPYSL2 NKD2 TMEM205

1.85e-04200253b6f21f5cc137eddf6ba90e81cae791b57d88d9d7
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW19-Neuronal-Neurons|GW19 / Sample Type, Dataset, Time_group, and Cell type.

DPYSL2 KHDRBS1 YTHDC1

1.85e-04200253b9538eb33ac86384e7e289a5a82fac4d56a7b9c2
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NKD2 HMCN1 ABLIM3

1.85e-042002533dd022e974fec7013ba18f333da63f58fbf2dd7c
ToppCell390C-Fibroblasts-Fibroblast-H|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

DPYSL2 NKD2 TMEM205

1.85e-04200253019340e8b4b4944a49e14fdec7ce2954cbb8ba2e
ToppCellBronchial-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NKD2 HMCN1 ABLIM3

1.85e-04200253e8462395fee0a532d1e7ec7f1795f28c42af6541
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-squamous_epithelial_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

MAP3K13 TCHP TJP1

1.85e-042002531c02a7f4047d1d2208cc522c6bb4a4989d7845bb
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Epithelial-Epithelial,_Airway-squamous_epithelial_cell-Epi-Squamous|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

MAP3K13 TCHP TJP1

1.85e-0420025303051d2190244208905e1611019d4b8fd200bae0
ToppCellBronchus_Control_(B.)-Stromal-TX-Fibroblasts-4|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

COLGALT2 NKD2 HMCN1

1.85e-0420025354b18c92daaa3b3368c0c46134b0c27e10c8dbb0
Diseasesexual dimorphism measurement

ACTR1A BPTF PXYLP1 COLGALT2 KHDRBS1 SLC4A1

2.06e-041106246EFO_0021796
Diseaselung adenocarcinoma

BPTF SPRED2 NKD2

3.72e-04174243EFO_0000571
Diseasebasophil count, eosinophil count

BPTF SPRED2 FOXA3

9.59e-04241243EFO_0004842, EFO_0005090
Diseaseneuroimaging measurement, brain volume measurement

ACTR1A BPTF DPYSL2

1.57e-03286243EFO_0004346, EFO_0006930
DiseaseBack pain

COLGALT2 FOXA3

2.27e-0387242HP_0003418
DiseaseDegenerative polyarthritis

DPYSL2 DAPP1

2.59e-0393242C0029408
DiseaseOsteoarthrosis Deformans

DPYSL2 DAPP1

2.59e-0393242C0086743
Diseaseeosinophil percentage of leukocytes

BPTF SPRED2 FOXA3 LYRM1

2.88e-03746244EFO_0007991
Diseasebrain ischemia (biomarker_via_orthology)

DPYSL2 TJP1

3.11e-03102242DOID:2316 (biomarker_via_orthology)
Diseasebrain connectivity measurement

ACTR1A DPYSL2 KCNJ16

4.05e-03400243EFO_0005210
Diseasestroke

CLDN17 DAPP1

6.08e-03144242EFO_0000712
Diseaseeosinophil count

BPTF SPRED2 FOXA3 TCHP LYRM1

6.17e-031488245EFO_0004842
Diseasephotoreceptor cell layer thickness measurement

KIF14 ABLIM3

6.42e-03148242EFO_0803370
Diseaselung carcinoma

BPTF SPRED2 NKD2

6.79e-03482243EFO_0001071

Protein segments in the cluster

PeptideGeneStartEntry
GDSNIYRKPPIYKRH

ABLIM3

436

O94929
PKYHPDVPYVKRVKT

SLC4A1

816

P02730
KNKPYIRHEPIGYDR

BPTF

451

Q12830
KKQGYRYPVPGYRVP

CLDN17

191

P56750
RYPVPGYRVPHTDKR

CLDN17

196

P56750
LQLKAFPKHYRPPEG

INPP4A

956

Q96PE3
KQPLRVREHPVYGPY

KIF14

516

Q15058
GRYIPRKPFPDFVYK

DPYSL2

466

Q16555
PPPPYGHKRYRQKGR

NKD2

376

Q969F2
SLKTIPVKYYPHRKP

HMCN1

371

Q96RW7
YPGTYKRHPVRPIIH

MAP3K13

511

O43283
KHPYPRKVEEPSIYE

DAPP1

126

Q9UN19
PKYCFPNYVGRPKHV

ACTR1A

31

P61163
IEIGLHYKIPYPRPI

LYRM1

71

O43325
PPARPVKGAYREHPY

KHDRBS1

426

Q07666
REHYGYLPIPLKPHQ

COLGALT2

286

Q8IYK4
GPDPYRQLREKDPKY

TMEM205

136

Q6UW68
PKGYRRPLAHAKPPY

FOXA3

106

P55318
RHGDRYPLYVIPKTK

PXYLP1

96

Q8TE99
YFEKIHPPGERRAPQ

ODF3L1

126

Q8IXM7
KYPGYPPEHIIAEKR

KCNJ16

16

Q9NPI9
YRHAPVRGKYPDPSE

SPRED2

231

Q7Z698
AEQGYRPKPYGHPKI

TCHP

481

Q9BT92
RKKPRIDYPPEFHQR

YTHDC1

546

Q96MU7
RKFPVPKPIDYNRHA

RIOK2

171

Q9BVS4
HVDPTKVYRKDPYPE

TJP1

996

Q07157
IHGRNPVREKPYKYP

ZNF329

136

Q86UD4