Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionP-type transmembrane transporter activity

ATP13A3 ATP1A1 ATP1A2 ATP2B2

2.52e-0536954GO:0140358
GeneOntologyMolecularFunctionP-type ion transporter activity

ATP13A3 ATP1A1 ATP1A2 ATP2B2

2.52e-0536954GO:0015662
GeneOntologyMolecularFunctionATP-dependent activity

KIF21B EP400 TDRD9 EIF4A3 SHPRH DDX53 ATP13A3 ATP1A1 ATP1A2 ATP2B2 KIF20B KIF2C

3.42e-056149512GO:0140657
GeneOntologyMolecularFunctionATP hydrolysis activity

KIF21B TDRD9 EIF4A3 DDX53 ATP13A3 ATP1A1 ATP1A2 ATP2B2 KIF20B KIF2C

4.72e-054419510GO:0016887
GeneOntologyMolecularFunctionmicrotubule plus-end binding

PAFAH1B1 FBXW11 KIF2C

1.50e-0422953GO:0051010
GeneOntologyMolecularFunctionATPase-coupled monoatomic cation transmembrane transporter activity

ATP13A3 ATP1A1 ATP1A2 ATP2B2

2.17e-0462954GO:0019829
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

KIF21B NUGGC TDRD9 EIF4A3 RASL11B DDX53 ATP13A3 ATP1A1 ATP1A2 ATP2B2 KIF20B KIF2C

3.06e-047759512GO:0017111
GeneOntologyMolecularFunctionsteroid hormone binding

ATP1A1 ATP1A2

4.63e-047952GO:1990239
GeneOntologyMolecularFunctionpyrophosphatase activity

KIF21B NUGGC TDRD9 EIF4A3 RASL11B DDX53 ATP13A3 ATP1A1 ATP1A2 ATP2B2 KIF20B KIF2C

6.21e-048399512GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

KIF21B NUGGC TDRD9 EIF4A3 RASL11B DDX53 ATP13A3 ATP1A1 ATP1A2 ATP2B2 KIF20B KIF2C

6.28e-048409512GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

KIF21B NUGGC TDRD9 EIF4A3 RASL11B DDX53 ATP13A3 ATP1A1 ATP1A2 ATP2B2 KIF20B KIF2C

6.28e-048409512GO:0016818
GeneOntologyMolecularFunctionhelicase activity

EP400 TDRD9 EIF4A3 SHPRH DDX53

9.51e-04158955GO:0004386
GeneOntologyMolecularFunctionP-type sodium transporter activity

ATP1A1 ATP1A2

9.83e-0410952GO:0008554
GeneOntologyMolecularFunctionP-type sodium:potassium-exchanging transporter activity

ATP1A1 ATP1A2

9.83e-0410952GO:0005391
GeneOntologyMolecularFunctionP-type potassium transmembrane transporter activity

ATP1A1 ATP1A2

1.20e-0311952GO:0008556
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ATP13A3 ATP1A1 ATP1A2 ATP2B2

1.83e-03109954GO:0042626
GeneOntologyMolecularFunctionpotassium ion binding

ATP1A1 ATP1A2

1.96e-0314952GO:0030955
GeneOntologyMolecularFunctionsodium ion binding

ATP1A1 ATP1A2

1.96e-0314952GO:0031402
GeneOntologyCellularComponentkinesin complex

KIF21B PAFAH1B1 KIF20B KIF2C

6.96e-0549944GO:0005871
DomainWD40

KIF21B CFAP251 EML5 CFAP52 WDR11 WDR88 PAFAH1B1 GNB1L WDR89 IFT80 THOC3 FBXW11

6.04e-092599312PF00400
DomainWD40

KIF21B CFAP251 EML5 CFAP52 WDR11 WDR88 PAFAH1B1 GNB1L WDR89 IFT80 THOC3 FBXW11

8.85e-092689312SM00320
DomainWD40_repeat

KIF21B CFAP251 EML5 CFAP52 WDR11 WDR88 PAFAH1B1 GNB1L WDR89 IFT80 THOC3 FBXW11

1.04e-082729312IPR001680
Domain-

KIF21B CFAP251 EML5 CFAP52 WDR11 WDR88 FSTL5 PAFAH1B1 GNB1L WDR89 IFT80 THOC3 FBXW11

1.05e-0833393132.130.10.10
DomainWD40/YVTN_repeat-like_dom

KIF21B CFAP251 EML5 CFAP52 WDR11 WDR88 FSTL5 PAFAH1B1 GNB1L WDR89 IFT80 THOC3 FBXW11

1.13e-083359313IPR015943
DomainWD_REPEATS_1

KIF21B CFAP251 EML5 CFAP52 WDR11 WDR88 PAFAH1B1 GNB1L WDR89 IFT80 THOC3 FBXW11

1.33e-082789312PS00678
DomainWD_REPEATS_2

KIF21B CFAP251 EML5 CFAP52 WDR11 WDR88 PAFAH1B1 GNB1L WDR89 IFT80 THOC3 FBXW11

1.39e-082799312PS50082
DomainWD_REPEATS_REGION

KIF21B CFAP251 EML5 CFAP52 WDR11 WDR88 PAFAH1B1 GNB1L WDR89 IFT80 THOC3 FBXW11

1.39e-082799312PS50294
DomainWD40_repeat_dom

KIF21B CFAP251 EML5 CFAP52 WDR11 WDR88 PAFAH1B1 GNB1L WDR89 IFT80 THOC3 FBXW11

2.77e-082979312IPR017986
DomainATPase_P-typ_cation-transptr_C

ATP13A3 ATP1A1 ATP1A2 ATP2B2

1.30e-0617934IPR006068
DomainCation_ATPase_C

ATP13A3 ATP1A1 ATP1A2 ATP2B2

1.30e-0617934PF00689
DomainWD40_repeat_CS

KIF21B EML5 CFAP52 WDR11 WDR88 PAFAH1B1 GNB1L FBXW11

1.61e-06164938IPR019775
DomainCation_ATPase_N

ATP13A3 ATP1A1 ATP1A2 ATP2B2

1.67e-0618934PF00690
DomainATPase_P-typ_cation-transptr_N

ATP13A3 ATP1A1 ATP1A2 ATP2B2

2.11e-0619934IPR004014
Domain-

ATP13A3 ATP1A1 ATP1A2 ATP2B2

1.86e-05329343.40.1110.10
Domain-

ATP13A3 ATP1A1 ATP1A2 ATP2B2

1.86e-05329342.70.150.10
DomainATPase_P-typ_cyto_domN

ATP13A3 ATP1A1 ATP1A2 ATP2B2

2.68e-0535934IPR023299
DomainP_typ_ATPase

ATP13A3 ATP1A1 ATP1A2 ATP2B2

3.00e-0536934IPR001757
DomainATPase_P-typ_P_site

ATP13A3 ATP1A1 ATP1A2 ATP2B2

3.00e-0536934IPR018303
DomainATPASE_E1_E2

ATP13A3 ATP1A1 ATP1A2 ATP2B2

3.00e-0536934PS00154
DomainATPase_P-typ_transduc_dom_A

ATP13A3 ATP1A1 ATP1A2 ATP2B2

3.35e-0537934IPR008250
DomainE1-E2_ATPase

ATP13A3 ATP1A1 ATP1A2 ATP2B2

3.35e-0537934PF00122
Domain-

ATP1A1 ATP1A2 ATP2B2

6.39e-05169331.20.1110.10
DomainATPase_P-typ_TM_dom

ATP1A1 ATP1A2 ATP2B2

6.39e-0516933IPR023298
DomainCation_ATPase_N

ATP1A1 ATP1A2 ATP2B2

9.24e-0518933SM00831
DomainHelicase_C

EP400 TDRD9 EIF4A3 SHPRH DDX53

1.96e-04107935PF00271
DomainHELICc

EP400 TDRD9 EIF4A3 SHPRH DDX53

1.96e-04107935SM00490
DomainHelicase_C

EP400 TDRD9 EIF4A3 SHPRH DDX53

2.04e-04108935IPR001650
DomainHELICASE_CTER

EP400 TDRD9 EIF4A3 SHPRH DDX53

2.13e-04109935PS51194
DomainHELICASE_ATP_BIND_1

EP400 TDRD9 EIF4A3 SHPRH DDX53

2.13e-04109935PS51192
DomainDEXDc

EP400 TDRD9 EIF4A3 SHPRH DDX53

2.13e-04109935SM00487
DomainHelicase_ATP-bd

EP400 TDRD9 EIF4A3 SHPRH DDX53

2.23e-04110935IPR014001
DomainP-type_ATPase_IIC

ATP1A1 ATP1A2

3.63e-046932IPR005775
DomainHAD-like_dom

ATP13A3 ATP1A1 ATP1A2 ATP2B2

6.51e-0479934IPR023214
DomainG-protein_beta_WD-40_rep

WDR88 PAFAH1B1 THOC3 FBXW11

8.57e-0485934IPR020472
DomainKinesin_motor_CS

KIF21B KIF20B KIF2C

1.11e-0341933IPR019821
DomainKinesin-like_fam

KIF21B KIF20B KIF2C

1.28e-0343933IPR027640
DomainKINESIN_MOTOR_1

KIF21B KIF20B KIF2C

1.37e-0344933PS00411
Domain-

KIF21B KIF20B KIF2C

1.37e-03449333.40.850.10
DomainKinesin_motor_dom

KIF21B KIF20B KIF2C

1.37e-0344933IPR001752
DomainKinesin

KIF21B KIF20B KIF2C

1.37e-0344933PF00225
DomainKINESIN_MOTOR_2

KIF21B KIF20B KIF2C

1.37e-0344933PS50067
DomainKISc

KIF21B KIF20B KIF2C

1.37e-0344933SM00129
DomainRas_G-nucl-exch_fac_CS

RASGRF1 RASGRF2

2.15e-0314932IPR019804
DomainQuinoprotein_ADH-like_supfam

CFAP251 EML5 WDR88

2.34e-0353933IPR011047
DomainRasGEFN

RASGRF1 RASGRF2

4.40e-0320932SM00229
DomainApc4_WD40_dom

EML5 THOC3

4.40e-0320932IPR024977
DomainANAPC4_WD40

EML5 THOC3

4.40e-0320932PF12894
DomainRasGEF_N

RASGRF1 RASGRF2

4.84e-0321932PF00618
Pubmed

WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy.

KIF21B PAFAH1B1 WDR89 IFT80

4.43e-064095429078390
Pubmed

RASGRF2 controls nuclear migration in postnatal retinal cone photoreceptors.

RASGRF1 RASGRF2

7.38e-06295226743081
Pubmed

Failure of fluid absorption in the endolymphatic sac initiates cochlear enlargement that leads to deafness in mice lacking pendrin expression.

SLC26A4 ATP1A1

7.38e-06295221103348
Pubmed

Microglia aggravate white matter injury via C3/C3aR pathway after experimental subarachnoid hemorrhage.

C3 C3AR1

7.38e-06295238866102
Pubmed

Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance.

ATP1A1 ATP1A2

7.38e-06295215781423
Pubmed

Dissociable effects of complement C3 and C3aR on survival and morphology of adult born hippocampal neurons, pattern separation, and cognitive flexibility in male mice.

C3 C3AR1

7.38e-06295234403734
Pubmed

Sphingosine 1-phosphate receptor type 1 regulates egress of mature T cells from mouse bone marrow.

MAP3K14 S1PR1

7.38e-06295220497959
Pubmed

C3a-C3aR signaling promotes breast cancer lung metastasis via modulating carcinoma associated fibroblasts.

C3 C3AR1

7.38e-06295231931851
Pubmed

Endothelial progenitor cell transplantation alleviated ischemic brain injury via inhibiting C3/C3aR pathway in mice.

C3 C3AR1

7.38e-06295231865842
Pubmed

Cyclic AMP plays a critical role in C3a-receptor-mediated regulation of dendritic cells in antigen uptake and T-cell stimulation.

C3 C3AR1

7.38e-06295218812470
Pubmed

Molecular cloning of the mouse ouabain-resistance gene.

ATP1A1 ATP1A2

7.38e-0629526324196
Pubmed

Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis.

C3 C3AR1

7.38e-06295228283064
Pubmed

Marinobufagenin enhances cardiac contractility in mice with ouabain-sensitive alpha1 Na+-K+-ATPase.

ATP1A1 ATP1A2

7.38e-06295219376809
Pubmed

A real-time PCR method to genotype mutant mouse models with altered affinity for cardiotonic steroids on the Na,K-ATPase.

ATP1A1 ATP1A2

7.38e-06295235446892
Pubmed

Defective engraftment of C3aR-/- hematopoietic stem progenitor cells shows a novel role of the C3a-C3aR axis in bone marrow homing.

C3 C3AR1

7.38e-06295219357704
Pubmed

Distinct roles for Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) and Ras-GRF2 in the induction of long-term potentiation and long-term depression.

RASGRF1 RASGRF2

7.38e-06295216467520
Pubmed

Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression.

C3 C3AR1

7.38e-06295229118090
Pubmed

New molecular determinants controlling the accessibility of ouabain to its binding site in human Na,K-ATPase alpha isoforms.

ATP1A1 ATP1A2

7.38e-06295214742675
Pubmed

C3a and C3b activation products of the third component of complement (C3) are critical for normal liver recovery after toxic injury.

C3 C3AR1

7.38e-06295215240660
Pubmed

Identification of a selective nonpeptide antagonist of the anaphylatoxin C3a receptor that demonstrates antiinflammatory activity in animal models.

C3 C3AR1

7.38e-06295211342658
Pubmed

Downregulation of complement C3 and C3aR expression in subcutaneous adipose tissue in obese women.

C3 C3AR1

7.38e-06295224743347
Pubmed

Receptor for complement peptide C3a: a therapeutic target for neonatal hypoxic-ischemic brain injury.

C3 C3AR1

7.38e-06295223737250
Pubmed

Negative regulation of pulmonary Th17 responses by C3a anaphylatoxin during allergic inflammation in mice.

C3 C3AR1

7.38e-06295223285141
Pubmed

The alpha(1)- and alpha(2)-isoforms of Na-K-ATPase play different roles in skeletal muscle contractility.

ATP1A1 ATP1A2

7.38e-06295211507009
Pubmed

Ras-GRF2 regulates nestin-positive stem cell density and onset of differentiation during adult neurogenesis in the mouse dentate gyrus.

RASGRF1 RASGRF2

7.38e-06295228966131
Pubmed

The environment versus genetics in controlling the contribution of MAP kinases to synaptic plasticity.

RASGRF1 RASGRF2

7.38e-06295217141611
Pubmed

DOCA-salt hypertension does not require the ouabain-sensitive binding site of the α2 Na,K-ATPase.

ATP1A1 ATP1A2

7.38e-06295222258333
Pubmed

Na(+)/K)+)-ATPase α2-isoform preferentially modulates Ca2(+) transients and sarcoplasmic reticulum Ca2(+) release in cardiac myocytes.

ATP1A1 ATP1A2

7.38e-06295222739122
Pubmed

Deletion of the complement anaphylatoxin C3a receptor attenuates, whereas ectopic expression of C3a in the brain exacerbates, experimental autoimmune encephalomyelitis.

C3 C3AR1

7.38e-06295215383607
Pubmed

The Inhibition of RasGRF2, But Not RasGRF1, Alters Cocaine Reward in Mice.

RASGRF1 RASGRF2

7.38e-06295231182637
Pubmed

Mobilization studies in mice deficient in either C3 or C3a receptor (C3aR) reveal a novel role for complement in retention of hematopoietic stem/progenitor cells in bone marrow.

C3 C3AR1

7.38e-06295214604969
Pubmed

Identification of a specific role for the Na,K-ATPase alpha 2 isoform as a regulator of calcium in the heart.

ATP1A1 ATP1A2

7.38e-06295210360172
Pubmed

Complement component 3C3 and C3a receptor are required in chitin-dependent allergic sensitization to Aspergillus fumigatus but dispensable in chitin-induced innate allergic inflammation.

C3 C3AR1

7.38e-06295223549917
Pubmed

Transgenerational rescue of a genetic defect in long-term potentiation and memory formation by juvenile enrichment.

RASGRF1 RASGRF2

7.38e-06295219193896
Pubmed

Complement pathway amplifies caspase-11-dependent cell death and endotoxin-induced sepsis severity.

C3 C3AR1

7.38e-06295227697835
Pubmed

The mouse anaphylatoxin C3a receptor: molecular cloning, genomic organization, and functional expression.

C3 C3AR1

7.38e-0629529164946
Pubmed

Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors.

RASGRF1 RASGRF2

7.38e-06295214749369
Pubmed

Ion pumps in polarized cells: sorting and regulation of the Na+, K+- and H+, K+-ATPases.

ATP1A1 ATP1A2

7.38e-06295211404365
Pubmed

Mice expressing ouabain-sensitive α1-Na,K-ATPase have increased susceptibility to pressure overload-induced cardiac hypertrophy.

ATP1A1 ATP1A2

7.38e-06295220952666
Pubmed

Ouabain-Sensitive alpha1 Na,K-ATPase enhances natriuretic response to saline load.

ATP1A1 ATP1A2

7.38e-06295218667729
Pubmed

Renovascular hypertension using a modified two-kidney, one-clip approach in mice is not dependent on the α1 or α2 Na-K-ATPase ouabain-binding site.

ATP1A1 ATP1A2

7.38e-06295221632957
Pubmed

The complement C3-C3aR pathway mediates microglia-astrocyte interaction following status epilepticus.

C3 C3AR1

7.38e-06295233314324
Pubmed

A murine CDC25/ras-GRF-related protein implicated in Ras regulation.

RASGRF1 RASGRF2

7.38e-0629528293576
Pubmed

Expression of alpha isoforms of the Na,K-ATPase in human heart.

ATP1A1 ATP1A2

7.38e-0629528391840
Pubmed

The Complement C3a-C3a Receptor Axis Regulates Epithelial-to-Mesenchymal Transition by Activating the ERK Pathway in Pancreatic Ductal Adenocarcinoma.

C3 C3AR1

7.38e-06295235220210
Pubmed

Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity.

ICOSLG MAP3K14

7.38e-06295225406581
Pubmed

Complement C3 Affects Rac1 Activity in the Developing Brain.

NES C3 C3AR1

8.77e-061595329867343
Pubmed

PGC-1α4 Interacts with REST to Upregulate Neuronal Genes and Augment Energy Consumption in Developing Cardiomyocytes.

ATP1A1 ATP1A2 ATP2B2

1.31e-051795336230906
Pubmed

Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are differentially expressed during nephrogenesis.

NPHS2 SLC26A4 ATP1A1

1.85e-051995316177003
Pubmed

Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons.

NES PAFAH1B1 POU3F3

2.18e-052095312130536
Pubmed

Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis.

C3 C3AR1

2.21e-05395220625009
Pubmed

Loss of decay-accelerating factor triggers podocyte injury and glomerulosclerosis.

C3 C3AR1

2.21e-05395232717081
Pubmed

Three differentially expressed Na,K-ATPase alpha subunit isoforms: structural and functional implications.

ATP1A1 ATP1A2

2.21e-0539522822726
Pubmed

Targeted transgenic expression of beta(2)-adrenergic receptors to type II cells increases alveolar fluid clearance.

ATP1A1 ATP1A2

2.21e-05395211557593
Pubmed

Na+/K+-ATPase α isoform deficiency results in distinct spreading depolarization phenotypes.

ATP1A1 ATP1A2

2.21e-05395230819023
Pubmed

Isoform specificity of the Na/K-ATPase association and regulation by phospholemman.

ATP1A1 ATP1A2

2.21e-05395219638348
Pubmed

RasGRF suppresses Cdc42-mediated tumour cell movement, cytoskeletal dynamics and transformation.

RASGRF1 RASGRF2

2.21e-05395221685891
Pubmed

Complement component C3a plays a critical role in endothelial activation and leukocyte recruitment into the brain.

C3 C3AR1

2.21e-05395226822321
Pubmed

Association between peripheral blood WBCs C3aR mRNA level and plasma C3a, C3aR, IL-1β concentrations and acute exacerbation of chronic obstructive pulmonary disease.

C3 C3AR1

2.21e-05395234923262
Pubmed

Characterization of the expression and regulation of genes necessary for myo-inositol biosynthesis and transport in the seminiferous epithelium.

ISYNA1 SLC5A3

2.21e-05395214613899
Pubmed

Simultaneously reduced NKCC1 and Na,K-ATPase expression in murine cochlear lateral wall contribute to conservation of endocochlear potential following a sensorineural hearing loss.

ATP1A1 ATP1A2

2.21e-05395221094218
Pubmed

Effect of resistance training on Na,K pump and Na+/H+ exchange protein densities in muscle from control and patients with type 2 diabetes.

ATP1A1 ATP1A2

2.21e-05395214685860
Pubmed

Transplantation studies in C3-deficient animals reveal a novel role of the third complement component (C3) in engraftment of bone marrow cells.

C3 C3AR1

2.21e-05395215284858
Pubmed

Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages.

C3 C3AR1

2.21e-05395236174103
Pubmed

In situ localization of sodium-potassium ATPase mRNA in developing mouse lung epithelium.

ATP1A1 ATP1A2

2.21e-0539527573462
Pubmed

Complement C3a-induced IL-17 plays a critical role in an IgE-mediated late-phase asthmatic response and airway hyperresponsiveness via neutrophilic inflammation in mice.

C3 C3AR1

2.21e-05395222539791
Pubmed

Components of the eIF4F complex are potential therapeutic targets for malignant peripheral nerve sheath tumors and vestibular schwannomas.

EIF4A3 EIF4E

2.21e-05395226951381
Pubmed

Differential expression of Na+/K+-ATPase alpha-subunits in mouse hippocampal interneurones and pyramidal cells.

ATP1A1 ATP1A2

2.21e-05395217947306
Pubmed

Complement C3a regulates late asthmatic response and airway hyperresponsiveness in mice.

C3 C3AR1

2.21e-05395219684087
Pubmed

Association between sodium- and potassium-activated adenosine triphosphatase alpha isoforms and bipolar disorders.

ATP1A1 ATP1A2

2.21e-05395219058785
Pubmed

Knockout of sodium pump α3 subunit gene (Atp1a3-/-) results in perinatal seizure and defective respiratory rhythm generation.

ATP1A1 ATP1A2

2.21e-05395228465228
Pubmed

Na,K-ATPase subunit isoforms in human reticulocytes: evidence from reverse transcription-PCR for the presence of alpha1, alpha3, beta2, beta3, and gamma.

ATP1A1 ATP1A2

2.21e-0539529159180
Pubmed

Targeted disruption of Ras-Grf2 shows its dispensability for mouse growth and development.

RASGRF1 RASGRF2

2.21e-05395211909944
Pubmed

Complement 3a induces the synapse loss via C3aR in mitochondria-dependent NLRP3 activating mechanisms during the development and progression of Alzheimer's disease.

C3 C3AR1

2.21e-05395239218048
Pubmed

Developmental cell-specific regulation of Na(+)-K(+)-ATPase alpha 1-, alpha 2-, and alpha 3-isoform gene expression.

ATP1A1 ATP1A2

2.21e-0539528203495
Pubmed

Translationally controlled tumor protein interacts with the third cytoplasmic domain of Na,K-ATPase alpha subunit and inhibits the pump activity in HeLa cells.

ATP1A1 ATP1A2

2.21e-05395215383549
Pubmed

Complement system is activated in stenotic aortic valves.

C3 C3AR1

2.21e-05395217498719
Pubmed

Purification of the human alpha2 Isoform of Na,K-ATPase expressed in Pichia pastoris. Stabilization by lipids and FXYD1.

ATP1A1 ATP1A2

2.21e-05395218052210
Pubmed

High glucose levels induce inhibition of Na,K-ATPase via stimulation of aldose reductase, formation of microtubules and formation of an acetylated tubulin/Na,K-ATPase complex.

ATP1A1 ATP1A2

2.21e-05395222565168
Pubmed

Na(+) pump alpha 2-isoform specifically couples to contractility in vascular smooth muscle: evidence from gene-targeted neonatal mice.

ATP1A1 ATP1A2

2.21e-05395214627611
Pubmed

Na,K-ATPase and the role of alpha isoforms in behavior.

ATP1A1 ATP1A2

2.21e-05395218044013
Pubmed

Antigen-presenting cell-derived complement modulates graft-versus-host disease.

C3 C3AR1

2.21e-05395222585573
Pubmed

Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1.

C3 C3AR1

2.21e-05395212511407
Pubmed

The alpha 1 isoform of Na,K-ATPase regulates cardiac contractility and functionally interacts and co-localizes with the Na/Ca exchanger in heart.

ATP1A1 ATP1A2

2.21e-05395215485817
Pubmed

Glutamate-system defects behind psychiatric manifestations in a familial hemiplegic migraine type 2 disease-mutation mouse model.

ATP1A1 ATP1A2

2.21e-05395226911348
Pubmed

Signaling through up-regulated C3a receptor is key to the development of experimental lupus nephritis.

C3 C3AR1

2.21e-05395216034139
Pubmed

Eukaryotic initiation Factor 4AIII facilitates hepatocellular carcinoma cell proliferation, migration, and epithelial-mesenchymal transition process via antagonistically binding to WD repeat domain 66 with miRNA-2113.

CFAP251 EIF4A3

2.21e-05395231975383
Pubmed

Complement C3 and C3aR mediate different aspects of emotional behaviours; relevance to risk for psychiatric disorder.

C3 C3AR1

2.21e-05395234543680
Pubmed

Cardiac glycosides induced toxicity in human cells expressing α1-, α2-, or α3-isoforms of Na-K-ATPase.

ATP1A1 ATP1A2

2.21e-05395225994790
Pubmed

The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation.

ATP1A1 ATP1A2

2.21e-05395216243970
Pubmed

Deficiency of the Complement Component 3 but Not Factor B Aggravates Staphylococcus aureus Septic Arthritis in Mice.

C3 C3AR1

2.21e-05395226787717
Pubmed

SLC26A4 targeted to the endolymphatic sac rescues hearing and balance in Slc26a4 mutant mice.

SLC26A4 ATP1A1

2.21e-05395223874234
Pubmed

Complement component C3 is required for protective innate and adaptive immunity to larval strongyloides stercoralis in mice.

C3 C3AR1

2.21e-05395216547268
Pubmed

Developmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras, Erk and CREB.

RASGRF1 RASGRF2

2.21e-05395215029245
Pubmed

Increased susceptibility to cortical spreading depression in the mouse model of familial hemiplegic migraine type 2.

ATP1A1 ATP1A2

4.41e-05495221731499
Pubmed

Subunit isoform selectivity in assembly of Na,K-ATPase α-β heterodimers.

ATP1A1 ATP1A2

4.41e-05495222696220
Pubmed

The Na,K-ATPase alpha 2 isoform is expressed in neurons, and its absence disrupts neuronal activity in newborn mice.

ATP1A1 ATP1A2

4.41e-05495212458206
Pubmed

C3a, C5a renal expression and their receptors are correlated to severity of IgA nephropathy.

C3 C3AR1

4.41e-05495224327134
Pubmed

Astrocyte-microglia interaction drives evolving neuromyelitis optica lesion.

C3 C3AR1

4.41e-05495232568214
Pubmed

Preactivation of AMPK by metformin may ameliorate the epithelial cell damage caused by renal ischemia.

ATP1A1 ATP1A2

4.41e-05495221849490
GeneFamilyWD repeat domain containing

KIF21B CFAP251 EML5 CFAP52 WDR11 WDR88 PAFAH1B1 GNB1L WDR89 IFT80 THOC3 FBXW11

2.36e-102626812362
GeneFamilyATPase Na+/K+ transporting subunits

ATP1A1 ATP1A2

2.89e-0476821208
GeneFamilyKinesins|Pleckstrin homology domain containing

KIF21B KIF20B KIF2C

6.88e-0446683622
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

FSTL5 LSAMP ADGRF5 ADGRA3

3.17e-03161684593
ToppCell343B-Epithelial_cells-Epithelial-A_(AT2)-|343B / Donor, Lineage, Cell class and subclass (all cells)

RASGRF1 TMEM63B C3 ADGRF5 ATP1A1 FGGY

1.42e-06164956beaa13a75c3bb72446c85084d75e9fe3f15fd3d4
ToppCell343B-Epithelial_cells-Epithelial-A_(AT2)|343B / Donor, Lineage, Cell class and subclass (all cells)

RASGRF1 TMEM63B C3 ADGRF5 ATP1A1 FGGY

1.42e-06164956d005cfd821b87548b075120bffe65a0be9860463
ToppCelldroplet-Trachea-3m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l19|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NES RASGRF2 ADGRF5 PARP14 ATP2B2 S1PR1

2.60e-06182956840427d1c23d60482c943ff006b14007ed44d247
ToppCelldroplet-Mammary_Gland-nan-3m-Endothelial|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSF2RB RASGRF2 ADGRF5 PARP14 S1PR1 AKAP12

3.23e-061899561d4ad307c0606957dd7bf8da84450e5193cf4a50
ToppCelldroplet-Mammary_Gland-nan-3m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSF2RB RASGRF2 ADGRF5 PARP14 S1PR1 AKAP12

3.23e-06189956b952026044d5f6c0adce60cf24f6e0199e6f8757
ToppCelldroplet-Mammary_Gland-nan-3m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSF2RB RASGRF2 ADGRF5 PARP14 S1PR1 AKAP12

3.23e-0618995625781edbd08c6e413740b796ecc8ba1934bd3aa5
ToppCellpdx-Tumor_cells-T8|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

NUGGC RBP5 CRPPA C3 ATP2B2 NAGS

3.33e-06190956b05db0de9b6ae01dd30074453f7de44f7397631e
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Endothelial-Endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NES ISYNA1 ADGRF5 N4BP3 S1PR1 AKAP12

3.65e-06193956e4b440d50ae7391b26924778be6d9d53e0692449
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Endothelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NES ISYNA1 ADGRF5 N4BP3 S1PR1 AKAP12

3.65e-06193956e523dc5751f6fdcd4fc1a62b1eecd43f6ae79da9
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Endothelial-endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NES ISYNA1 ADGRF5 N4BP3 S1PR1 AKAP12

3.65e-061939561772f2ac217727de63c4a9303881b3a19a6bb0f0
ToppCellTracheal-10x5prime-Endothelial-Endothelia_vascular-VE_capillary|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

NES CSF2RB RBP5 ADGRF5 TEX15 S1PR1

3.99e-06196956f0b106078212be1d0938f545707a004a1e830857
ToppCellTCGA-Skin-Metastatic-Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

KIF21B RBP5 C3 C3AR1 ADGRF5 AKAP12

4.23e-06198956af4fb9eb2295c7b90624b38ba25619aa15254efa
ToppCellTCGA-Skin-Metastatic|TCGA-Skin / Sample_Type by Project: Shred V9

KIF21B RBP5 C3 C3AR1 ADGRF5 AKAP12

4.23e-06198956ad39cce004867f083f8da1954e0cf5a263815184
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

KIF21B RBP5 C3 C3AR1 ADGRF5 AKAP12

4.23e-0619895662cbf4b29e8af4983fb47a17f96da62682a5137e
ToppCellLung_Parenchyma-Control-Endothelial-Endothelial-Lymphatic-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PALD1 SLC26A4 OXGR1 N4BP3 S1PR1 AKAP12

4.48e-06200956f99d0d3f51b4893fa7898c5b435494358a654cbd
ToppCellLung_Parenchyma-Control-Endothelial-Endothelial-Lymphatic|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

PALD1 SLC26A4 OXGR1 N4BP3 S1PR1 AKAP12

4.48e-06200956e65d4ae3d48f68c12edd5dc2c2f4e25e4acfadf1
ToppCellParenchyma_Control_(B.)-Endothelial-TX-Lymphatic|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

PALD1 SLC26A4 OXGR1 N4BP3 S1PR1 AKAP12

4.48e-062009564ec8e30dd241d83a1bba1c5967b6a4656afbfafd
ToppCelldistal-2-Endothelial-Capillary_Intermediate_1|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PALD1 NES ADGRF5 N4BP3 S1PR1 AKAP12

4.48e-062009567a99f28670ffb8ece7873d8a9bcd2a3936d0255d
ToppCelldistal-Endothelial-Capillary_Intermediate_1-2|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PALD1 NES ADGRF5 N4BP3 S1PR1 AKAP12

4.48e-0620095643bc48413b100a06f8edd9acd812296788fcbf5b
ToppCelldistal-Endothelial-Capillary_Intermediate_1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PALD1 NES ADGRF5 N4BP3 S1PR1 AKAP12

4.48e-062009564d6714d48738cdee7d535923f6dd2431e5304741
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c02-NCAM1|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ISYNA1 LSAMP C3AR1 POU3F3 N4BP3

2.25e-051589554d997efc36fd8946775fe74dd9ac9ccd5ade64ff
ToppCellClub-club-2|World / Class top

NUGGC TDRD9 MAP3K14 ELAPOR1 C3

2.85e-0516695556f11efb6b686b3ee2c34a051f626e3d761b5112
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NES RASGRF2 ADGRF5 S1PR1 NAGS

3.57e-051749553d4c05ea5719ca65e85d1f15198453034791087c
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Endothelial-nan|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSF2RB RASGRF2 ADGRF5 PARP14 S1PR1

3.57e-05174955fa6eb451555766398996bbe8f555a3f4c0f3c108
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Endothelial|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSF2RB RASGRF2 ADGRF5 PARP14 S1PR1

3.57e-051749551f5b0fa58b2a7335667357af7e50e5242cd13d7d
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSF2RB RASGRF2 ADGRF5 PARP14 S1PR1

3.57e-05174955ac3aee6ed49d1c421f33509e3ffc5cb17750a473
ToppCell10x3'2.3-week_14-16-Myeloid_neutrophil-granulo-eo/baso/mast-basophil|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

KIF21B NIBAN1 CSF2RB TDRD9 S1PR1

3.77e-05176955581d78811b2d99f38a2c7cc268aeb1cf932379c2
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CACNA1B EML5 LCORL ELAPOR1 GPR179

3.87e-051779558abdf1d970b2f15e17e185f3e612dd5065c88757
ToppCellfacs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l7|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NES NUGGC RASGRF2 ADGRF5 S1PR1

3.98e-05178955a3f95f0002f408b5b6c57e28b297b5b2737e919c
ToppCell390C-Epithelial_cells-Epithelial-B_(AT2)|390C / Donor, Lineage, Cell class and subclass (all cells)

RASGRF1 TMEM63B C3 ADGRF5 FGGY

4.09e-05179955466da2bc3bfc534ffe111c8c28ece7a3cfa08051
ToppCell390C-Epithelial_cells-Epithelial-B_(AT2)-|390C / Donor, Lineage, Cell class and subclass (all cells)

RASGRF1 TMEM63B C3 ADGRF5 FGGY

4.09e-05179955f4bdebb77d39e63160fbf3a85a340ce4d52b7cfd
ToppCellAT2_cells-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

RASGRF1 TMEM63B C3 ADGRF5 FGGY

4.31e-05181955ed0ea67f0607073aedf153f8d1073b35e46127c3
ToppCellfacs-Marrow-T-cells-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSF2RB MAN1C1 C3AR1 ATP13A3 ATP1A1

4.31e-051819557286700396676fdc41d9723979b8b408177aceb9
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D175|Adult / Lineage, Cell type, age group and donor

PALD1 NES GADL1 CRPPA S1PR1

4.42e-051829558b4a07ebd7a133a33ef333cfa29d12c4f3d4d9ac
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-Bergmann_glial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ICOSLG NPHS2 MAN1C1 LSAMP ATP1A2

4.54e-0518395599bb4ceb92f6467f2359a42ab2cff6df18825a30
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Endothelial-endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NES ISYNA1 ADGRF5 S1PR1 AKAP12

4.78e-051859557f46ea82a663181957f88e4e83114aef8a78820c
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Endothelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NES ISYNA1 ADGRF5 S1PR1 AKAP12

4.78e-05185955956fb0043c0c3e4e5c4d6f58ff95faf6209c380e
ToppCellAT2_cells-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

RASGRF1 TMEM63B C3 ADGRF5 FGGY

4.78e-051859553b3268e3f99121124e33086cac88479808d31630
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Endothelial-Endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NES ISYNA1 ADGRF5 S1PR1 AKAP12

4.91e-05186955a58c9d1567da0961e0e295a156773d2252ee5a1a
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_3|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

KDM5A IFT80 INTS8 GCN1 FGGY

5.03e-05187955689b3cc76f1e04bd35a7d3ce19e9f08744a7835b
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

KDM5A IFT80 INTS8 GCN1 FGGY

5.03e-051879554527d6426f2c4397e47f12439a13a8c14fd2aab2
ToppCelldroplet-Lung-LUNG-30m-Endothelial-Capillary_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NES ADGRF5 N4BP3 S1PR1 AKAP12

5.03e-0518795552ffd4be374e329ac8d321063f061b826d252956
ToppCelldroplet-Mammary_Gland-nan-21m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NES CSF2RB RASGRF2 ADGRF5 AKAP12

5.16e-0518895505de6677f9bb4b00fed47f4b72f4a2cd507cb0f2
ToppCell5'-Adult-Distal_Rectal-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ISYNA1 OXGR1 ADGRF5 S1PR1 AKAP12

5.16e-05188955524a12f433c7b6f33fad36c0716afa06cd3235e9
ToppCell5'-Adult-Distal_Rectal-Endothelial-lymphatic_endothelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ISYNA1 OXGR1 ADGRF5 S1PR1 AKAP12

5.16e-05188955d2610b81b3c7f22977b5e2137b1f61410fc4ef16
ToppCellChildren_(3_yrs)-Immune-T_lymphocyte-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

PCNX2 NIBAN1 RASGRF2 SFI1 THOC3

5.29e-05189955df30478b288084a1bd48f660409dcc784040897c
ToppCell5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-Stromal_3_(C7+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADRB3 LSAMP C3 WNK3 PPL

5.29e-05189955f7d57723b8fb0f1e1485f51e3eff93ec0f39761e
ToppCellIPF-Endothelial-VE_Capillary_A|World / Disease state, Lineage and Cell class

PALD1 NES ADGRF5 N4BP3 S1PR1

5.29e-05189955ea3aa3ef38f1d405bb527ae383cd12c551a3dd6f
ToppCelldroplet-Mammary_Gland-nan-21m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NES CSF2RB RASGRF2 ADGRF5 AKAP12

5.29e-051899558ced0381ea042ba47680a02b617a2368fa2c54c8
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RASGRF1 TMEM63B C3 ATP1A1 FGGY

5.29e-05189955e90ba6f6d7ba0698d04d84278aa035c28803733e
ToppCellAT2_cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

RASGRF1 TMEM63B C3 ADGRF5 FGGY

5.29e-051899552d32f09efa982ae458568f6b1cd06bb5078d42a3
ToppCelldroplet-Mammary_Gland-nan-21m-Endothelial|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NES CSF2RB RASGRF2 ADGRF5 AKAP12

5.29e-05189955403a82bb416aed13b9d31411ad17bdc4ce2a95fb
ToppCellGlobus_pallidus-Neuronal|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

PCNX2 CACNA1B RASGRF1 ELAPOR1 ATP2B2

5.43e-05190955416de85d8841dac883faa6f5339b2fb461a09e82
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CFAP52 RASL11B C3 PPL AKAP12

5.43e-05190955050d6e0546954675b6adbfecb67854b1e09739d1
ToppCellIPF-Endothelial-VE_Capillary_A|IPF / Disease state, Lineage and Cell class

PALD1 NES ADGRF5 N4BP3 S1PR1

5.43e-05190955b4e35cbfe4d43d2cd51f29c3085e4d9b1012e6f0
ToppCelldroplet-Fat-BAT+GAT+MAT-30m-Endothelial-endothelial_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NES RASGRF2 ADGRF5 N4BP3 S1PR1

5.43e-05190955c8370c922e0cf0e0c36e02e1ed2b4053ad6a8073
ToppCelldroplet-Fat-BAT+GAT+MAT-30m-Endothelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NES RASGRF2 ADGRF5 N4BP3 S1PR1

5.43e-051909555174f91a880f85bb20806023aa68bd4b8ca24ea5
ToppCelldroplet-Fat-BAT+GAT+MAT-30m-Endothelial|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NES RASGRF2 ADGRF5 N4BP3 S1PR1

5.43e-0519095590e494cbfbed33a3a0d29bb7dae83f0c81580bcf
ToppCellwk_08-11-Epithelial-Proximal_epithelial-GHRL+_neuroendocrine|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

CACNA1B SLC26A4 FSTL5 ELAPOR1 PPL

5.43e-05190955b5c6f3248c0c2f648e1578457c6a729ca22bf0da
ToppCell(7)_Epithelial-E_(AT2)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

RASGRF1 TMEM63B C3 ADGRF5 FGGY

5.56e-051919550fc8d109d5c50957ceef5b8b8b818b0c598b1bbe
ToppCelldroplet-Mammary_Gland-nan-18m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSF2RB RASGRF2 ADGRF5 S1PR1 AKAP12

5.70e-05192955945153c41dde6e90d103206955e1707b54eb0665
ToppCelldroplet-Mammary_Gland-nan-18m-Endothelial|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSF2RB RASGRF2 ADGRF5 S1PR1 AKAP12

5.70e-051929556ab50579c63f31ca2cd41063a99b129f11c07510
ToppCellfacs-Lung-EPCAM-18m-Mesenchymal|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADRB3 RASL11B C3 ATP1A2 ITGB5

5.70e-051929555876ff75e273a48e7ad8236423fb41e4ae4c0a91
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCNX2 RASGRF1 RASGRF2 SGSM2 ATP2B2

5.84e-05193955be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCell368C-Fibroblasts-Fibroblast-K_(Pericytes)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

NIBAN1 ISYNA1 RASL11B ADGRF5 ATP1A2

5.84e-051939555260ac95a15cc43a19909badad0c7e3854da920d
ToppCellCOVID-19-Endothelial_cells-Inflamed_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

NES RASGRF2 ADGRF5 S1PR1 AKAP12

5.84e-05193955979ebefa527f86bebeea5d94e626ee6c1cc7d53b
ToppCell(6)_Endothelial-C_(Capillary_Aerocyte_)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

PALD1 NES ADGRF5 N4BP3 S1PR1

5.84e-05193955f7f2dc6aff02d096a282835094d26d12b3b73e61
ToppCell3'-GW_trimst-1-LargeIntestine-Endothelial-blood_vessel_EC-cycling_EC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NIBAN1 RBP5 ADGRF5 N4BP3 S1PR1

5.84e-05193955807fa1443b3c883cb318c71f4fca3c41d58f4910
ToppCell368C-Fibroblasts-Fibroblast-K_(Pericytes)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

NIBAN1 ISYNA1 RASL11B ADGRF5 ATP1A2

5.84e-051939555ec917931b438dd0e7fb03eb6af459d3ef6b84ba
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCNX2 RASGRF1 RASGRF2 SGSM2 ATP2B2

5.84e-051939550c652ebe22ce5d2927599dd97ef1920547858395
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCNX2 RASGRF1 RASGRF2 SGSM2 ATP2B2

5.84e-051939558689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCellHippocampus-Neuronal|Hippocampus / BrainAtlas - Mouse McCarroll V32

PCNX2 CACNA1B UBE2O ELAPOR1 ATP2B2

5.99e-051949558aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCellCOPD-Endothelial-VE_Capillary_B|World / Disease state, Lineage and Cell class

PALD1 NES ADGRF5 S1PR1 AKAP12

5.99e-0519495568705a6eca947c5b42b943d5224a7aef2a744007
ToppCellIPF-Endothelial|IPF / Disease state, Lineage and Cell class

NES RASGRF2 ADGRF5 S1PR1 AKAP12

5.99e-051949559591993aa2dcba3d09a0f1ea8b8f2439c26482d6
ToppCell(7)_Epithelial_cells|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

RASGRF1 TMEM63B C3 ADGRF5 FGGY

5.99e-05194955413e8b9f1e15be363a7f4a8f727af3eeb9e9a928
ToppCellAT2|World / shred by cell class for parenchyma

RASGRF1 TMEM63B ADGRF5 ATP1A1 FGGY

5.99e-05194955e773f5ef3abce7113a6b7cc7cbe68de873d4a17f
ToppCellCOPD-Endothelial-VE_Capillary_B|COPD / Disease state, Lineage and Cell class

PALD1 NES ADGRF5 S1PR1 AKAP12

5.99e-0519495518b7f901c12ca4f21f9a1eafd092aefe4d668b6d
ToppCelldroplet-Lung-30m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_endothelial_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NES ADGRF5 N4BP3 S1PR1 AKAP12

5.99e-05194955fc3f81b5bdc544a69c355e482f002643e029a7b0
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RASGRF1 TMEM63B C3 ADGRF5 FGGY

5.99e-051949550db439a544cf8f918a77058fd70319ab0e8e645e
ToppCell356C-Epithelial_cells|356C / Donor, Lineage, Cell class and subclass (all cells)

RASGRF1 TMEM63B C3 ADGRF5 FGGY

6.14e-05195955d913d0a6c4797d9a873ddea6f340c3f152da1cf3
ToppCell(7)_Epithelial-A_(AT2)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

RASGRF1 TMEM63B C3 ADGRF5 FGGY

6.14e-05195955c9a6c65ee18d83bf34a4713d306a6e30db1325c2
ToppCellcellseq-Epithelial-Epithelial_Alveolar-AT2-AT2|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

RASGRF1 C3 ADGRF5 ATP1A1 FGGY

6.14e-051959556867f9c56ea27a17c8c4099aae0d79903c3748a5
ToppCellproximal-Endothelial-Capillary_Aerocyte|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PALD1 NES RASGRF2 N4BP3 S1PR1

6.14e-05195955f1cbf82484f489fe7e0b5de6a49ea28d69f04e1a
ToppCellfacs-Lung-ENDOMUCIN-18m-Endothelial-Capillary_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NES ADGRF5 ATP1A1 N4BP3 S1PR1

6.14e-0519595552b2bbf12e5f86c493f6634697aeb23a68cc916d
ToppCellproximal-Endothelial-Capillary_Aerocyte-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PALD1 NES RASGRF2 N4BP3 S1PR1

6.14e-0519595513168c9632b58dd65ecb365df3832d95e7325919
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCNX2 CACNA1B RASGRF1 ELAPOR1 GPR101

6.14e-05195955ffbab350e67d9c4b66c0ab84550daec8b8139a27
ToppCelldroplet-Mammary_Gland-nan-18m-Endothelial-endothelial_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CSF2RB RASGRF2 ADGRF5 S1PR1 AKAP12

6.14e-051959554db30b3bc65c25626f828cd4f867f20c71809898
ToppCell390C-Epithelial_cells-Epithelial-C_(AT2)|390C / Donor, Lineage, Cell class and subclass (all cells)

RASGRF1 TMEM63B C3 ADGRF5 FGGY

6.14e-05195955d0608db4a61576e67f4a3a52e1f84d788a1dea85
ToppCell390C-Epithelial_cells-Epithelial-C_(AT2)-|390C / Donor, Lineage, Cell class and subclass (all cells)

RASGRF1 TMEM63B C3 ADGRF5 FGGY

6.14e-05195955bdfe486d32cb598950c1a5f5cdab40302c8f0f99
ToppCellCerebellum-Endothelial|Cerebellum / BrainAtlas - Mouse McCarroll V32

NES ISYNA1 ADGRF5 PARP14 AKAP12

6.14e-051959552192fd9b4682054776f0716933aed5a4a9412657
ToppCellproximal-3-Endothelial-Capillary_Aerocyte|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

PALD1 NES RASGRF2 N4BP3 S1PR1

6.14e-0519595536b2e754ed7ff138ac05fb51f4494e5339669828
ToppCellfacs-Heart-LA-3m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LSAMP C3 ATP1A2 ITGB5 AKAP12

6.14e-0519595579a6e8e6de040ff07539e8901fc407363a50e355
ToppCellcellseq-Epithelial-Epithelial_Alveolar-AT2|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

RASGRF1 C3 ADGRF5 ATP1A1 FGGY

6.14e-05195955955a0a7244cd7eaf006a39e1bd03333baf6f30a4
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.0.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

RASGRF1 TMEM63B C3 ADGRF5 FGGY

6.14e-0519595537aa6e4123d37de4de42ca68d3020f2a7686ce02
ToppCellAT2_cells-SSc-ILD_02|World / lung cells shred on cell class, cell subclass, sample id

RASGRF1 TMEM63B C3 ATP1A1 FGGY

6.14e-05195955bb45a17871a8a2593bc16a95f22e3c239c49985b
ToppCelldroplet-Lung-30m-Endothelial-capillary_endothelial-capillary_endothelial_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NES ADGRF5 N4BP3 S1PR1 AKAP12

6.29e-051969559e737eaa98fd49972fce64d1d4a4d1f34b9bcb96
ToppCell356C-Epithelial_cells-Epithelial-A_(AT2)|356C / Donor, Lineage, Cell class and subclass (all cells)

RASGRF1 TMEM63B C3 ADGRF5 FGGY

6.29e-0519695593a5d9b8bcff7d07596ef1f4f2b74f043835fc69
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NES RASGRF2 ADGRF5 ATP13A3 S1PR1

6.29e-05196955cf7f384c1771274e766bab03ecc3dfbd13f2df60
ToppCellASK440-Epithelial-Type_2|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

RASGRF1 C3 ADGRF5 ATP1A1 FGGY

6.29e-05196955754b4202b617165c6994a0b5a9b1e486dccdd44d
ToppCellKidney-Mesangial|Kidney / Skin and Kidney Cells in Lupus Nephritis Patients.

NES NIBAN1 ISYNA1 ATP1A2 GPR101

6.29e-051969552b2cbe7f96213b7ff50442593f31820d17a2ae94
DiseaseBipolar Disorder

CACNA1B RASGRF1 FSTL5 GNB1L ATP1A1 ATP1A2 S1PR1 F9 SLC5A3

2.02e-05477939C0005586
Diseaselow density lipoprotein cholesterol measurement, multiple sclerosis

CSF2RB MAP3K14

1.46e-046932EFO_0004611, MONDO_0005301
Diseasefamilial hemiplegic migraine (implicated_via_orthology)

ATP1A1 ATP1A2

2.04e-047932DOID:0060178 (implicated_via_orthology)
Diseasebrain ischemia (biomarker_via_orthology)

NES CSF2RB C3 AKAP12

3.10e-04102934DOID:2316 (biomarker_via_orthology)
Diseasemembranous glomerulonephritis (implicated_via_orthology)

NPHS2 C3

3.49e-049932DOID:10976 (implicated_via_orthology)
Diseaseresponse to methylphenidate

RASGRF2 LSAMP

3.49e-049932GO_0036271
Diseasenervous system disease (implicated_via_orthology)

ATP1A1 ATP1A2

6.35e-0412932DOID:863 (implicated_via_orthology)
Diseasehyperhomocysteinemia (biomarker_via_orthology)

ATP1A1 ATP1A2

6.35e-0412932DOID:9279 (biomarker_via_orthology)
DiseaseNephrosis

NES NPHS2

1.00e-0315932C0027720
Diseasebehavioural disinhibition measurement

PALD1 EIF4E CRPPA

1.74e-0375933EFO_0006946
Diseasefeeling miserable measurement

PAFAH1B1 LSAMP RERE

2.02e-0379933EFO_0009598
Diseasesusceptibility to shingles measurement

LCORL AGPAT3 CRPPA

2.16e-0381933EFO_0008401
Diseaseatrophic macular degeneration

C3 TEX15

2.81e-0325932EFO_1001492
Diseasecarpal tunnel syndrome

PALD1 CRPPA ITGB5

2.83e-0389933EFO_0004143
DiseaseIntellectual Disability

CACNA1B KDM5A EIF4A3 POU3F3 ATP1A1 FBXW11

2.94e-03447936C3714756

Protein segments in the cluster

PeptideGeneStartEntry
TAFTRVRWKCLVIDE

EP400

1206

Q96L91
ERECEVLRKIWSSAQ

CDY2A

511

Q9Y6F7
RKVDTSVSWEALICV

AKAP12

671

Q02952
VSITVEESVDRWGKC

ATP13A3

1156

Q9H7F0
WVKEKNITVRDTRCV

ADGRA3

201

Q8IWK6
WEVCVDREEVATVCK

CLDN25

51

C9JDP6
VVADSVWVDVKDSCV

C3

546

P01024
VWVDVKDSCVGSLVV

C3

551

P01024
KRCARTAVVLVWVVS

ADRB3

151

P13945
FRVAVVVVAVFLVCW

C3AR1

376

Q16581
QCDAELRKEISVVWA

CACNA1B

1816

Q00975
VICVVLVTAFNDWSK

ATP2B2

161

Q01814
LATISDAEVQKVCIW

CFAP251

361

Q8TBY9
RRTAKDLWEVVVQIC

INTS8

711

Q75QN2
QTVRVWVVATKECKA

PAFAH1B1

256

P43034
DKVIVLWTANTERFC

ISYNA1

221

Q9NPH2
RVCWIKDIVVAVTGE

CRPPA

86

A4D126
KVVWVSLREEAVLEC

PALD1

541

Q9ULE6
ICKEIVERWSETQNV

CCDC43

76

Q96MW1
VLWDVSEQKVCSRIA

GNB1L

191

Q9BYB4
LVAVENAWRKAQEVC

IRAK1BP1

176

Q5VVH5
SVETRVAEVCLWEVV

GPR179

2106

Q6PRD1
IVVVQWADLVICKTR

ATP1A1

926

P05023
ETCAVLQKVALWARA

LCORL

341

Q8N3X6
EQRVTICKTIDFWLK

ELAPOR1

896

Q6UXG2
VIFCNTKRKVDWLTE

EIF4A3

281

P38919
VRAKGDKIAIWTTEC

EIF4E

156

P06730
SVVVWSIAKRDAICG

CFAP52

136

Q8N1V2
VTDVLKWDLIVCAVV

PCNX2

1091

A6NKB5
KWDLIVCAVVAVLSF

PCNX2

1096

A6NKB5
VKLRSQECDWEEISV

PPL

1686

O60437
AAELVCKEWQRVISE

FBXW11

146

Q9UKB1
IVNEKWIVTAAHCVE

F9

256

P00740
WIVTAAHCVETGVKI

F9

261

P00740
IKVWDIRDSAKCIRT

KIF21B

1371

O75037
SIEAIWEECKEIVKA

KIF20B

1056

Q96Q89
SVTCIWGIKVERIEI

NPHS2

251

Q9NP85
VEAEKCARAWLSSQV

NES

116

P48681
KSWCQEELSVAVKRA

GCN1

936

Q92616
LDLVCNAEWVSTKER

NAGS

316

Q8N159
CFLAVLAVWVDVETQ

GPR101

416

Q96P66
CRDEVITWVDTIVKD

ITGB5

661

P18084
VSERWEEKAKVCLQA

KDM5A

951

P29375
CASEEKIWEVLNIIR

MAGEA13P

211

A6NCF6
DEVQRCVWASAVNVK

FSTL5

496

Q8N475
LVVVAVAIGWVCRDR

ICOSLG

266

O75144
KTRCAVVACAVVWII

OXGR1

146

Q96P68
VVACAVVWIISLVAV

OXGR1

151

Q96P68
KAVDIVKQVWDSVCV

PARP14

726

Q460N5
ASIVVVQWADLIICK

ATP1A2

921

P50993
AVLSCSWEVRKEVAS

CSF2RB

256

P32927
WEDAVRLCRFVKEQT

IFT80

601

Q9P2H3
EDIWAACCVVTKKVV

FGGY

56

Q96C11
CSWLTAIFRIKDDEI

TMEM63B

126

Q5T3F8
TCWILVCNKVVAIVL

GET1

156

O00258
IEWTVGVCRDSVERK

BTN2A1

396

Q7KYR7
VALIRDTKWLTLEVC

MBNL3

6

Q9NUK0
WEVVLALEKYCRTEA

MAN1C1

546

Q9NR34
IRAAVVECEKRKWAD

DDX53

156

Q86TM3
DVCIWRDIFLVKTVK

EML5

886

Q05BV3
SVQETDRILVEKRCW

EMC4

56

Q5J8M3
VLKATDVNEKVCEWR

GADL1

61

Q6ZQY3
KTVIIVLSVFIACWA

S1PR1

256

P21453
VRTVNLEKSCVSVEW

KIF2C

31

Q99661
DSLQLEKEVVRVWFC

POU3F3

441

P20264
TVASELWEKLTARCV

DRP2

206

Q13474
EVVLGRSCDAKVDVW

MAP3K14

566

Q99558
RKCQTIVTWEEEHLV

RBP5

81

P82980
RCIRWADAVVIVFSI

RASL11B

106

Q9BPW5
FIVLINCIDWVSKRE

TAS2R13

26

Q9NYV9
ICSKVLVQWREAVSV

SFI1

716

A8K8P3
KCSVIWVISDIERVS

NUGGC

311

Q68CJ6
ISKFRCVWIEKESIN

TDRD9

1166

Q8NDG6
LRCVVEDKNSKVAWL

LSAMP

51

Q13449
ANAIEKWVAVADICR

RASGRF2

1071

O14827
VLAEWKACEVVVRQR

SGSM2

606

O43147
CCQDVVVKLRKISDW

SHPRH

941

Q149N8
WCADQVIVQRVLAAK

SLC5A3

276

P53794
LIEKCWTEDEVKRFV

RERE

391

Q9P2R6
RVSAIEKWVAVADIC

RASGRF1

1106

Q13972
SLAACLVVEAVVWKS

ADGRF5

1026

Q8IZF2
CAIIEDVILRFAWTI

XPR1

561

Q9UBH6
RWKRLETHDVVIECA

TSC1

246

Q92574
SCEKISEVIVRDWLV

TRMT61B

381

Q9BVS5
SEVIVRDWLVCLAKQ

TRMT61B

386

Q9BVS5
ASVSLDRCIKIWDVT

WDR88

246

Q6ZMY6
IVFCKRKWEEDRDTV

AGPAT3

141

Q9NRZ7
EEIKVARIHECQWVV

NIBAN1

881

Q9BZQ8
KIDAVIWVFTCIVSI

SLC26A4

476

O43511
SAFWKVVVRVVCTKI

RNF141

71

Q8WVD5
CIAVAVVWAVFRNED

SPPL2A

296

Q8TCT8
ALVSLWDVDELVCVR

THOC3

246

Q96J01
VARVDVSSKVEVVWA

UBE2O

681

Q9C0C9
CWKVTRSVEDAEIKT

TSKS

196

Q9UJT2
KRVRVVWESILEECG

SMCO1

116

Q147U7
DGTVKCWDARVAREK

WDR89

91

Q96FK6
DVCLWKVIETAVSEL

TEX15

2121

Q9BXT5
FRILDVDWCTSDKVI

WDR11

796

Q9BZH6
VEVAWCELQDRKLTK

WNK3

171

Q9BYP7
ARWEVCQKTAEISLL

N4BP3

366

O15049