Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	inositol 1,4,5-trisphosphate-gated calcium channel activity	ITPR1 ITPR3	9.66e-05	3	114	2	GO:0005220
GeneOntologyMolecularFunction	heparan sulfate 6-O-sulfotransferase activity	HS6ST1 HS6ST3	9.66e-05	3	114	2	GO:0017095
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	RYR1 ITPR1 ITPR3	1.39e-04	18	114	3	GO:0015278
GeneOntologyBiologicalProcess	release of sequestered calcium ion into cytosol	EDNRA RYR1 ITPR1 ITPR3 LHCGR PLCB1 CCR7	1.59e-05	146	113	7	GO:0051209
GeneOntologyBiologicalProcess	negative regulation of sequestering of calcium ion	EDNRA RYR1 ITPR1 ITPR3 LHCGR PLCB1 CCR7	1.66e-05	147	113	7	GO:0051283
GeneOntologyBiologicalProcess	regulation of sequestering of calcium ion	EDNRA RYR1 ITPR1 ITPR3 LHCGR PLCB1 CCR7	1.82e-05	149	113	7	GO:0051282
GeneOntologyBiologicalProcess	sequestering of calcium ion	EDNRA RYR1 ITPR1 ITPR3 LHCGR PLCB1 CCR7	2.16e-05	153	113	7	GO:0051208
GeneOntologyBiologicalProcess	calcium ion homeostasis	TMTC2 INPP4B EDNRA RYR1 ITPR1 ITPR3 CUL5 LHCGR PLCB1 CCR7	5.61e-05	389	113	10	GO:0055074
Domain	ARM-type_fold	PDS5B CLTCL1 DOCK9 UBR4 INTS1 IPO4 TRIP12 LYST ITPR1 MTOR AP4B1 TARBP1 IPO11	1.25e-07	339	112	13	IPR016024
Domain	RIH_assoc-dom	RYR1 ITPR1 ITPR3	4.14e-06	6	112	3	IPR013662
Domain	Ins145_P3_rec	RYR1 ITPR1 ITPR3	4.14e-06	6	112	3	PF08709
Domain	RIH_assoc	RYR1 ITPR1 ITPR3	4.14e-06	6	112	3	PF08454
Domain	RIH_dom	RYR1 ITPR1 ITPR3	4.14e-06	6	112	3	IPR000699
Domain	Ins145_P3_rcpt	RYR1 ITPR1 ITPR3	4.14e-06	6	112	3	IPR014821
Domain	Ryanodine_recept-rel	RYR1 ITPR1 ITPR3	4.14e-06	6	112	3	IPR015925
Domain	-	RYR1 ITPR1 ITPR3	4.14e-06	6	112	3	1.25.10.30
Domain	RYDR_ITPR	RYR1 ITPR1 ITPR3	4.14e-06	6	112	3	PF01365
Domain	MIR	RYR1 ITPR1 ITPR3	2.44e-05	10	112	3	PF02815
Domain	MIR_motif	RYR1 ITPR1 ITPR3	2.44e-05	10	112	3	IPR016093
Domain	MIR	RYR1 ITPR1 ITPR3	2.44e-05	10	112	3	PS50919
Domain	MIR	RYR1 ITPR1 ITPR3	2.44e-05	10	112	3	SM00472
Domain	LIM-bd/SEUSS	LDB2 LDB1	3.56e-05	2	112	2	IPR029005
Domain	InsP3_rcpt-bd	ITPR1 ITPR3	1.07e-04	3	112	2	IPR000493
Domain	Heparan_SO4-6-sulfoTrfase	HS6ST1 HS6ST3	1.07e-04	3	112	2	IPR010635
Domain	TPR-like_helical_dom	CLTCL1 TTC36 TMTC2 ZFC3H1 NAA25 MTOR CFAP46	5.13e-04	233	112	7	IPR011990
Domain	HEAT_REPEAT	PDS5B IPO4 MTOR IPO11	8.29e-04	70	112	4	PS50077
Domain	ARM-like	PDS5B IPO4 TRIP12 MTOR AP4B1 TARBP1 IPO11	1.22e-03	270	112	7	IPR011989
Domain	LRR_5	LRRC4C LHCGR	1.55e-03	10	112	2	PF13306
Domain	LRR_5	LRRC4C LHCGR	1.55e-03	10	112	2	IPR026906
Domain	-	CLTCL1 TTC36 TMTC2 NAA25 MTOR CFAP46	1.56e-03	207	112	6	1.25.40.10
Domain	-	PDS5B IPO4 TRIP12 MTOR AP4B1 IPO11	2.22e-03	222	112	6	1.25.10.10
Domain	Sulfotransfer_2	HS6ST1 HS6ST3	2.26e-03	12	112	2	PF03567
Domain	Sulfotransferase	HS6ST1 HS6ST3	2.26e-03	12	112	2	IPR005331
Domain	Dynein_HC_stalk	DNHD1 DNAH11	3.09e-03	14	112	2	IPR024743
Domain	Dynein_heavy_dom-2	DNHD1 DNAH11	3.09e-03	14	112	2	IPR013602
Domain	DHC_N2	DNHD1 DNAH11	3.09e-03	14	112	2	PF08393
Domain	IMPORTIN_B_NT	IPO4 IPO11	3.09e-03	14	112	2	PS50166
Domain	ATPase_dyneun-rel_AAA	MDN1 DNAH11	3.09e-03	14	112	2	IPR011704
Domain	MT	DNHD1 DNAH11	3.09e-03	14	112	2	PF12777
Domain	AAA_5	MDN1 DNAH11	3.09e-03	14	112	2	PF07728
Domain	TPR_REGION	TTC36 TMTC2 ZFC3H1 NAA25 CFAP46	3.18e-03	165	112	5	PS50293
Domain	TPR	TTC36 TMTC2 ZFC3H1 NAA25 CFAP46	3.18e-03	165	112	5	PS50005
Domain	DHC_fam	DNHD1 DNAH11	3.56e-03	15	112	2	IPR026983
Domain	Dynein_heavy	DNHD1 DNAH11	3.56e-03	15	112	2	PF03028
Domain	IBN_N	IPO4 IPO11	3.56e-03	15	112	2	PF03810
Domain	Dynein_heavy_dom	DNHD1 DNAH11	3.56e-03	15	112	2	IPR004273
Domain	IBN_N	IPO4 IPO11	4.05e-03	16	112	2	SM00913
Domain	PH_dom-like	ARHGAP42 ARHGEF5 DOCK9 LYST JAK3 PLCB1 PHLPP1 AGAP1	4.14e-03	426	112	8	IPR011993
Domain	Importin-beta_N	IPO4 IPO11	4.57e-03	17	112	2	IPR001494
Domain	HEAT	IPO4 MTOR IPO11	5.10e-03	58	112	3	IPR000357
Pathway	KEGG_MEDICUS_REFERENCE_GPCR_PLCB_ITPR_SIGNALING_PATHWAY	EDNRA ITPR1 ITPR3 LHCGR PLCB1	1.08e-05	50	83	5	M47951
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SPTBN2_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR1 ITPR3 PLCB1	2.29e-05	10	83	3	M47661
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PRKCG_TO_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR1 ITPR3 PLCB1	3.14e-05	11	83	3	M49033
Pathway	WP_CELLTYPE_DEPENDENT_SELECTIVITY_OF_CCK2R_SIGNALING	RYR1 ITPR1 PLCB1	5.39e-05	13	83	3	M39589
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR1_TRPC3_SIGNALING_PATHWAY	ITPR1 ITPR3 PLCB1	5.39e-05	13	83	3	M47656
Pathway	WP_AIRWAY_SMOOTH_MUSCLE_CELL_CONTRACTION	RYR1 ITPR3 PLCB1	1.04e-04	16	83	3	M40060
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	RYR1 ITPR1 ITPR3	1.78e-04	19	83	3	M47760
Pathway	KEGG_MEDICUS_REFERENCE_MACHR_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR3 PLCB1	2.09e-04	20	83	3	M47688
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MACHR_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR3 PLCB1	2.42e-04	21	83	3	M47689
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR3 PLCB1	2.80e-04	22	83	3	M47690
Pathway	KEGG_MEDICUS_REFERENCE_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR3 PLCB1	2.80e-04	22	83	3	M47675
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	ITPR1 ITPR3 PLCB1	3.20e-04	23	83	3	M47676
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY	ITPR1 ITPR3	3.39e-04	5	83	2	M49000
Pathway	REACTOME_CA2_PATHWAY	ITPR1 ITPR3 FZD5 PLCB1	4.81e-04	62	83	4	M27321
Pathway	KEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY	ITPR1 ITPR3	5.06e-04	6	83	2	M47960
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR1 ITPR1 ITPR3	6.81e-07	6	114	3	23463619
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR1 ITPR1 ITPR3	6.81e-07	6	114	3	25966694
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR1 ITPR1 ITPR3	6.81e-07	6	114	3	20519450
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR1 ITPR1 ITPR3	6.81e-07	6	114	3	16844763
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR1 ITPR1 ITPR3	1.19e-06	7	114	3	11860456
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	PDS5B UBR4 INTS1 DIS3 CUL5 LIG3 PLK1 SPEN IPO11	1.98e-06	341	114	9	32971831
Pubmed	Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx.	ITPR1 ITPR3 PLCB1	2.84e-06	9	114	3	15623527
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	PDS5B UBR4 INTS1 MED13L TRIP12 MDN1 INTS2 PLEC	3.40e-06	272	114	8	31010829
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	KNTC1 CLTCL1 RPS6KA3 UBR4 IPO4 DIS3 ITPR1 ITPR3 CUL5 LIG3 POLR3B MDN1 LDB1 MTOR BUB1B IKBKB IPO11	4.68e-06	1440	114	17	30833792
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	UBR4 CHEK1 TRIP12 CUL5 MDN1 MTOR PLEC PLK1	5.17e-06	288	114	8	23383273
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	PDS5B UBR4 INTS1 IPO4 TRIP12 DIS3 ITPR3 MDN1 MTOR PLEC SPEN	1.05e-05	653	114	11	22586326
Pubmed	Ectopic expression of Plk1 leads to activation of the spindle checkpoint.	CHEK1 PLK1	1.07e-05	2	114	2	17102638
Pubmed	Aberrant Activation of Cell-Cycle-Related Kinases and the Potential Therapeutic Impact of PLK1 or CHEK1 Inhibition in Uterine Leiomyosarcoma.	CHEK1 PLK1	1.07e-05	2	114	2	35302600
Pubmed	The Pro335 --> Leu polymorphism of type 3 inositol 1,4,5-trisphosphate receptor found in mouse inbred lines results in functional change.	ITPR1 ITPR3	1.07e-05	2	114	2	15890645
Pubmed	Long-term potentiation and long-term depression in hippocampal CA1 neurons of mice lacking the IP(3) type 1 receptor.	RYR1 ITPR1	1.07e-05	2	114	2	12654335
Pubmed	mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells.	MTOR PHLPP1	1.07e-05	2	114	2	21177869
Pubmed	The role of PLK1-phosphorylated SVIL in myosin II activation and cytokinetic furrowing.	SVIL PLK1	1.07e-05	2	114	2	23750008
Pubmed	Inositol 1,4,5-trisphosphate receptor 1, a widespread Ca2+ channel, is a novel substrate of polo-like kinase 1 in eggs.	ITPR1 PLK1	1.07e-05	2	114	2	18621368
Pubmed	Novel treatment for mantle cell lymphoma including therapy-resistant tumor by NF-κB and mTOR dual-targeting approach.	MTOR IKBKB	1.07e-05	2	114	2	23963361
Pubmed	[Expression of checkpoint kinase 1 and polo-like kinase 1 and its clinicopathological significance in benign and malignant lesions of the stomach].	CHEK1 PLK1	1.07e-05	2	114	2	21051833
Pubmed	Spliced isoforms of LIM-domain-binding protein (CLIM/NLI/Ldb) lacking the LIM-interaction domain.	LDB2 LDB1	1.07e-05	2	114	2	16815859
Pubmed	DNA damage-induced S and G2/M cell cycle arrest requires mTORC2-dependent regulation of Chk1.	CHEK1 MTOR	1.07e-05	2	114	2	25460505
Pubmed	Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells.	ITPR1 ITPR3	1.07e-05	2	114	2	7559486
Pubmed	RSK2 is a new Pim2 target with pro-survival functions in FLT3-ITD-positive acute myeloid leukemia.	PIM2 RPS6KA3	1.07e-05	2	114	2	28914261
Pubmed	Structural studies of inositol 1,4,5-trisphosphate receptor: coupling ligand binding to channel gating.	ITPR1 ITPR3	1.07e-05	2	114	2	20843799
Pubmed	Cloning and chromosomal localization of two novel human genes encoding LIM-domain binding factors CLIM1 and CLIM2/LDB1/NLI.	LDB2 LDB1	1.07e-05	2	114	2	9799849
Pubmed	Checkpoint kinase 1 (Chk1) is required for mitotic progression through negative regulation of polo-like kinase 1 (Plk1).	CHEK1 PLK1	1.07e-05	2	114	2	16873548
Pubmed	Mutational analysis of the ligand binding site of the inositol 1,4,5-trisphosphate receptor.	ITPR1 ITPR3	1.07e-05	2	114	2	8663526
Pubmed	Mitotic entry upon Topo II catalytic inhibition is controlled by Chk1 and Plk1.	CHEK1 PLK1	1.07e-05	2	114	2	32144855
Pubmed	Inhibiting PLK1 induces autophagy of acute myeloid leukemia cells via mammalian target of rapamycin pathway dephosphorylation.	MTOR PLK1	1.07e-05	2	114	2	28184925
Pubmed	Polo-like kinase 1 facilitates chromosome alignment during prometaphase through BubR1.	BUB1B PLK1	1.07e-05	2	114	2	17376779
Pubmed	Polo-like kinase1 is required for recruitment of dynein to kinetochores during mitosis.	DNHD1 PLK1	1.07e-05	2	114	2	21507953
Pubmed	Jak3 is involved in dendritic cell maturation and CCR7-dependent migration.	JAK3 CCR7	1.07e-05	2	114	2	19759904
Pubmed	Regulation of CHK1 by mTOR contributes to the evasion of DNA damage barrier of cancer cells.	CHEK1 MTOR	1.07e-05	2	114	2	28484242
Pubmed	Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues.	ITPR1 ITPR3	1.07e-05	2	114	2	1374893
Pubmed	Mechanism of nodal flow: a conserved symmetry breaking event in left-right axis determination.	INVS DNAH11	1.07e-05	2	114	2	15907475
Pubmed	Influence of chk1 and plk1 silencing on radiation- or cisplatin-induced cytotoxicity in human malignant cells.	CHEK1 PLK1	1.07e-05	2	114	2	16927022
Pubmed	Common allosteric mechanisms between ryanodine and inositol-1,4,5-trisphosphate receptors.	RYR1 ITPR3	1.07e-05	2	114	2	21150295
Pubmed	Tyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening.	ITPR1 ITPR3	1.07e-05	2	114	2	20813840
Pubmed	Isolation and chromosomal assignment of human genes encoding cofactor of LIM homeodomain proteins, CLIM1 and CLIM2.	LDB2 LDB1	1.07e-05	2	114	2	10083735
Pubmed	Integration of kinase and phosphatase activities by BUBR1 ensures formation of stable kinetochore-microtubule attachments.	BUB1B PLK1	1.07e-05	2	114	2	23079597
Pubmed	Expression and reconstitution of the bioluminescent Ca(2+) reporter aequorin in human embryonic stem cells, and exploration of the presence of functional IP3 and ryanodine receptors during the early stages of their differentiation into cardiomyocytes.	RYR1 ITPR1	1.07e-05	2	114	2	27430888
Pubmed	Abnormal nodal flow precedes situs inversus in iv and inv mice.	INVS DNAH11	1.07e-05	2	114	2	10549278
Pubmed	Distinct roles of inositol 1,4,5-trisphosphate receptor types 1 and 3 in Ca2+ signaling.	ITPR1 ITPR3	1.07e-05	2	114	2	14707143
Pubmed	Synergistic Signaling by Light and Acetylcholine in Mouse Iris Sphincter Muscle.	ITPR1 ITPR3 PLCB1	1.52e-05	15	114	3	28578927
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	CLTCL1 DOCK9 UBR4 INTS1 HECTD4 MED13L LYST RYR1 ITPR3 JAK3 MDN1 MTOR PLEC SPEN	1.61e-05	1105	114	14	35748872
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	UBR4 HECTD4 FBXW4 DARS1 ZFC3H1 MED13L TRIP12 LDB2 FRY NAA25 POLR3B LDB1 PLEC TARBP1 AGAP1	2.04e-05	1285	114	15	35914814
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	DOCK9 HECTD4 DIS3 EDNRA LDB2 ITPR1 MDN1 PLEC	2.74e-05	363	114	8	14691545
Pubmed	Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.	ITPR1 ITPR3	3.19e-05	3	114	2	10874040
Pubmed	Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.	ITPR1 ITPR3	3.19e-05	3	114	2	20395455
Pubmed	Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.	ITPR1 ITPR3	3.19e-05	3	114	2	17437169
Pubmed	Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.	ITPR1 ITPR3	3.19e-05	3	114	2	18547250
Pubmed	Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.	ITPR1 ITPR3	3.19e-05	3	114	2	36350267
Pubmed	The versatility and universality of calcium signalling.	ITPR1 ITPR3	3.19e-05	3	114	2	11413485
Pubmed	Regulation of T-lymphocyte trafficking by ICAM-1, MAdCAM-1, and CCR7 in microcirculation of appendicular and intestinal lymphoid tissues.	CCR7 MADCAM1	3.19e-05	3	114	2	15371130
Pubmed	Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR3	3.19e-05	3	114	2	26009177
Pubmed	Cofactors of LIM Domains Associate with Estrogen Receptor α to Regulate the Expression of Noncoding RNA H19 and Corneal Epithelial Progenitor Cell Function.	LDB2 LDB1	3.19e-05	3	114	2	27129775
Pubmed	Receptor-activated single channels in intact human platelets.	ITPR1 ITPR3	3.19e-05	3	114	2	1693919
Pubmed	Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.	ITPR1 ITPR3	3.19e-05	3	114	2	23955339
Pubmed	The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine.	HS6ST1 HS6ST3	3.19e-05	3	114	2	10644753
Pubmed	Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.	ITPR1 ITPR3	3.19e-05	3	114	2	31979185
Pubmed	Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.	ITPR1 ITPR3	3.19e-05	3	114	2	24904548
Pubmed	Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins.	LDB2 LDB1	3.19e-05	3	114	2	8918878
Pubmed	Association of breast cancer risk and the mTOR pathway in women of African ancestry in 'The Root' Consortium.	RPS6KA3 MTOR	3.19e-05	3	114	2	28582508
Pubmed	Defects in inositol 1,4,5-trisphosphate receptor expression, Ca(2+) signaling, and insulin secretion in the anx7(+/-) knockout mouse.	ITPR1 PLCB1	3.19e-05	3	114	2	10570150
Pubmed	Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis.	ITPR1 ITPR3	3.19e-05	3	114	2	18250332
Pubmed	Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.	ITPR1 ITPR3	3.19e-05	3	114	2	9858485
Pubmed	Mammalian target of rapamycin (mTOR) is involved in the survival of cells mediated by chemokine receptor 7 through PI3K/Akt in metastatic squamous cell carcinoma of the head and neck.	MTOR CCR7	3.19e-05	3	114	2	19615795
Pubmed	Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.	ITPR1 ITPR3	3.19e-05	3	114	2	9808793
Pubmed	Identification of KRAP-expressing cells and the functional relevance of KRAP to the subcellular localization of IP3R in the stomach and kidney.	ITPR1 ITPR3	3.19e-05	3	114	2	22992961
Pubmed	Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.	ITPR1 ITPR3	3.19e-05	3	114	2	18194433
Pubmed	Mitotic DNA damage response: Polo-like kinase-1 is dephosphorylated through ATM-Chk1 pathway.	CHEK1 PLK1	3.19e-05	3	114	2	20581453
Pubmed	Differential expression of heparan sulfate 6-O-sulfotransferase isoforms in the mouse embryo suggests distinctive roles during organogenesis.	HS6ST1 HS6ST3	3.19e-05	3	114	2	15499561
Pubmed	Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels.	ITPR1 ITPR3	3.19e-05	3	114	2	12032348
Pubmed	Inositol 1,4,5-trisphosphate receptors selectively localized to the acrosomes of mammalian sperm.	ITPR1 PLCB1	3.19e-05	3	114	2	7642703
Pubmed	IP3 receptors regulate vascular smooth muscle contractility and hypertension.	ITPR1 ITPR3	3.19e-05	3	114	2	27777977
Pubmed	Substrate specificities of mouse heparan sulphate glucosaminyl 6-O-sulphotransferases.	HS6ST1 HS6ST3	3.19e-05	3	114	2	12611590
Pubmed	Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.	ITPR1 ITPR3	3.19e-05	3	114	2	17581770
Pubmed	Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.	ITPR1 ITPR3	3.19e-05	3	114	2	18241669
Pubmed	Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.	ITPR1 ITPR3	3.19e-05	3	114	2	19068129
Pubmed	Ubiquitination and proteasomal degradation of endogenous and exogenous inositol 1,4,5-trisphosphate receptors in alpha T3-1 anterior pituitary cells.	ITPR1 ITPR3	3.19e-05	3	114	2	12421829
Pubmed	Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.	ITPR1 ITPR3	3.19e-05	3	114	2	17327232
Pubmed	Furry protein promotes aurora A-mediated Polo-like kinase 1 activation.	FRY PLK1	3.19e-05	3	114	2	22753416
Pubmed	Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium spark signaling in adult mammalian skeletal muscle.	RYR1 ITPR1	3.19e-05	3	114	2	23223241
Pubmed	Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.	ITPR1 ITPR3	3.19e-05	3	114	2	16014380
Pubmed	Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus.	INVS DNAH11	3.19e-05	3	114	2	8610013
Pubmed	Mild replication stress causes premature centriole disengagement via a sub-critical Plk1 activity under the control of ATR-Chk1.	CHEK1 PLK1	3.19e-05	3	114	2	37773176
Pubmed	Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.	ITPR1 ITPR3	3.19e-05	3	114	2	17890015
Pubmed	The TSC1-mTOR-PLK axis regulates the homeostatic switch from Schwann cell proliferation to myelination in a stage-specific manner.	MTOR PLK1	3.19e-05	3	114	2	29722913
Pubmed	Heparan sulfate 6-O-sulfotransferase isoform-dependent regulatory effects of heparin on the activities of various proteases in mast cells and the biosynthesis of 6-O-sulfated heparin.	HS6ST1 HS6ST3	3.19e-05	3	114	2	23223449
Pubmed	Intracellular calcium release channel expression during embryogenesis.	RYR1 ITPR1	3.19e-05	3	114	2	9986730
Pubmed	Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.	ITPR1 ITPR3	3.19e-05	3	114	2	23983250
Pubmed	The Ldb1 and Ldb2 transcriptional cofactors interact with the Ste20-like kinase SLK and regulate cell migration.	LDB2 LDB1	3.19e-05	3	114	2	19675209
Pubmed	Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.	ITPR1 ITPR3	3.19e-05	3	114	2	20427533
Pubmed	Overexpression of heparan sulfate 6-O-sulfotransferases in human embryonic kidney 293 cells results in increased N-acetylglucosaminyl 6-O-sulfation.	HS6ST1 HS6ST3	3.19e-05	3	114	2	16326709
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	ARHGEF5 DARS1 IPO4 MTOR EXOC6B IPO11	3.26e-05	183	114	6	23956138
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	KNTC1 IPO4 TRIP12 ITPR3 MTOR PLEC	5.65e-05	202	114	6	33005030
Pubmed	Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels.	RYR1 ITPR3	6.36e-05	4	114	2	22100703
Pubmed	Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.	ITPR1 ITPR3	6.36e-05	4	114	2	25215520
Pubmed	Insulin promotes the association of heat shock protein 90 with the inositol 1,4,5-trisphosphate receptor to dampen its Ca2+ release activity.	ITPR1 MTOR	6.36e-05	4	114	2	19147678
Interaction	SCN2B interactions	PDS5B KNTC1 SPPL3 IPO4 MDN1 INTS2 MTOR EXOC6B TARBP1 IPO11	9.69e-11	95	109	10	int:SCN2B
Interaction	C3orf18 interactions	PDS5B KNTC1 INTS1 MDN1 MTOR EXOC6B TARBP1 IPO11	2.07e-07	115	109	8	int:C3orf18
Interaction	NPTN interactions	PDS5B KNTC1 CLTCL1 INTS1 SPG11 IPO4 FCSK MDN1 MTOR TARBP1 IPO11	3.28e-07	278	109	11	int:NPTN
Interaction	GPR17 interactions	PDS5B KNTC1 INTS1 SPPL3 SPG11 NAA25 MDN1 INTS2 MTOR TARBP1 IPO11	3.91e-07	283	109	11	int:GPR17
Interaction	FAM234A interactions	PDS5B KNTC1 INTS2 MTOR EXOC6B TARBP1 IPO11	5.55e-06	126	109	7	int:FAM234A
Interaction	HS6ST3 interactions	SPPL3 HS6ST1 HS6ST3	1.26e-05	9	109	3	int:HS6ST3
Interaction	COMTD1 interactions	KNTC1 INTS1 DARS1 IPO4 INTS2 MTOR BUB1B IPO11	1.32e-05	200	109	8	int:COMTD1
Interaction	FPR1 interactions	KNTC1 INTS1 SPG11 FCSK INTS2 MTOR IPO11	1.52e-05	147	109	7	int:FPR1
Interaction	HCST interactions	PDS5B INTS1 SPG11 FCSK MDN1 INTS2 MTOR TARBP1	1.58e-05	205	109	8	int:HCST
Interaction	OPALIN interactions	PDS5B KNTC1 INTS1 MDN1 INTS2 MTOR TARBP1 IPO11	1.81e-05	209	109	8	int:OPALIN
Interaction	MLNR interactions	PDS5B KNTC1 INTS1 INTS2 IPO11	3.35e-05	68	109	5	int:MLNR
Interaction	GPR45 interactions	KNTC1 INTS1 SPPL3 SPG11 FCSK MDN1 INTS2 MTOR IPO11	3.69e-05	300	109	9	int:GPR45
Interaction	CD80 interactions	PDS5B KNTC1 INTS1 INTS2 MTOR	6.92e-05	79	109	5	int:CD80
Interaction	SLC15A1 interactions	PDS5B KNTC1 SPPL3 INTS2 IPO11	7.35e-05	80	109	5	int:SLC15A1
Interaction	TCN2 interactions	CLTCL1 TCN2 INTS1	8.19e-05	16	109	3	int:TCN2
Interaction	H2AP interactions	KNTC1 SPG11 H2AP MTOR TARBP1	8.27e-05	82	109	5	int:H2AP
Interaction	VIPR2 interactions	PDS5B INTS1 SPG11 INTS2 MTOR CHAC1 IPO11	8.95e-05	194	109	7	int:VIPR2
Interaction	PRKY interactions	CLTCL1 SPG11 TRIP12 DIS3 LIG3 IKBKB	1.14e-04	140	109	6	int:PRKY
Interaction	CHRM4 interactions	PDS5B KNTC1 SPPL3 IPO4 IPO11	1.58e-04	94	109	5	int:CHRM4
Interaction	KLHDC1 interactions	SPPL3 CUL5	1.73e-04	4	109	2	int:KLHDC1
Interaction	GPR182 interactions	PDS5B KNTC1 INTS1 SPPL3 SPG11 FCSK MDN1 MTOR TARBP1 IPO11	1.81e-04	455	109	10	int:GPR182
GeneFamily	Inositol 1,4,5-triphosphate receptors\|Protein phosphatase 1 regulatory subunits	ITPR1 ITPR3	4.81e-05	3	73	2	297
GeneFamily	Olfactory receptors, family 3	OR3A2 OR3A3	2.39e-04	6	73	2	150
GeneFamily	Zinc fingers\|Zinc fingers PARP-type\|Poly(ADP-ribose) polymerases	ZFC3H1 LIG3	1.63e-03	15	73	2	26
GeneFamily	Integrator complex	INTS1 INTS2	1.63e-03	15	73	2	1366
GeneFamily	Armadillo repeat containing\|Importins	IPO4 IPO11	2.36e-03	18	73	2	596
Coexpression	GSE24210_CTRL_VS_IL35_TREATED_TCONV_CD4_TCELL_UP	SPG11 SYS1 MED13L ITPR1 ITPR3 JAK3 FRY AP4B1 INVS NCKAP1L	1.68e-08	200	113	10	M7841
Coexpression	GSE3565_DUSP1_VS_WT_SPLENOCYTES_POST_LPS_INJECTION_UP	PDS5B PIM2 INTS1 IPO4 LYST INPP4B MDN1 CCR7	6.08e-07	165	113	8	M6332
Coexpression	BUSSLINGER_GASTRIC_IMMUNE_CELLS	PDS5B PIM2 DOCK9 RPS6KA3 UBR4 HECTD4 DARS1 SPG11 ZFC3H1 TRIP12 LYST INPP4B ITPR1 FAM78A JAK3 MFNG AP4B1 SPEN NCKAP1L	2.01e-05	1492	113	19	M40023
Coexpression	GSE3982_BCELL_VS_TH2_DN	RPS6KA3 PAQR4 INPP4B EDNRA GSTT1 BUB1B PLK1	2.56e-05	199	113	7	M5555
Coexpression	GSE24210_RESTING_TREG_VS_TCONV_UP	SYS1 MED13L INPP4B ITPR1 ITPR3 FAM78A FRY	2.64e-05	200	113	7	M7839
Coexpression	FINETTI_BREAST_CANCER_KINOME_RED	CHEK1 BUB1B PLK1	4.19e-05	16	113	3	M9389
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 PDE3A INPP4B EDNRA FRY HS6ST3 DNAH11	3.52e-07	177	113	7	4943d040eee0f9dceaddc7498171281d170e271f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 PDE3A INPP4B EDNRA FRY HS6ST3 DNAH11	3.52e-07	177	113	7	3f2272b577c862dba8ccfb41184054bbd0ace6f5
ToppCell	Bronchial-NucSeq-Stromal-Pericyte-Muscle_pericyte_pulmonary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP42 PDE3A INPP4B EDNRA LDB2 PLCB1 SLC25A52	7.74e-07	199	113	7	929f809579368201331d9099d8904b6e3c41797b
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Vein\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	KLHL1 TMTC2 LRRC4C LDB2 FRY PLCB1 PLEC	8.01e-07	200	113	7	7eb366b2c5394af7c77650bde6261e7dac67154e
ToppCell	LPS_only-Endothelial-Endothelial-Vein\|LPS_only / Treatment groups by lineage, cell group, cell type	KLHL1 DOCK9 TMTC2 LRRC4C LDB2 PLCB1 PLEC	8.01e-07	200	113	7	b036f5e22c95a3b14391785b6e91aa183b9bc9a8
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE-P5-P5_1\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	KNTC1 CHEK1 B3GNT6 BUB1B PARPBP PLK1	3.52e-06	161	113	6	0dd1401b4c990d49fccb702a9f9867590a58e203
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE-P5-P5_1-Mitotic.MkI67_(Mitotic.MkI67)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	KNTC1 CHEK1 B3GNT6 BUB1B PARPBP PLK1	3.52e-06	161	113	6	b6a31c033edc74f23a20aab1f18e80cc83ffee4c
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE-P5\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	KNTC1 CHEK1 B3GNT6 BUB1B PARPBP PLK1	3.52e-06	161	113	6	efb811dda4d73107983a5f68302bdcf4f408d5b4
ToppCell	Globus_pallidus-Macroglia-POLYDENDROCYTE-P5-P5_1-Mitotic.MkI67_(Mitotic.MkI67)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	KNTC1 CHEK1 B3GNT6 BUB1B PARPBP PLK1	3.52e-06	161	113	6	28d5dbd20c9f8e0069f172d552997a044790e1a7
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ARHGAP42 PDE3A INPP4B EDNRA FRY PLCB1	5.51e-06	174	113	6	015d3742d3d79a57413a333f00ef2d380a9848dd
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 PDE3A INPP4B EDNRA HS6ST3 DNAH11	6.07e-06	177	113	6	a8625d14682183cf77cb51eaf11bc15a3528f586
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 PDE3A INPP4B EDNRA HS6ST3 DNAH11	6.07e-06	177	113	6	3645e2f4a48283f290f85c49c3e79e3f58ac9aa6
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ARHGAP42 PDE3A INPP4B EDNRA PLCB1 AGAP1	6.27e-06	178	113	6	185b44700f06ec58b3c09c80520502166c965fd6
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TCN2 DOCK9 GSDMC LYST LDB2 MADCAM1	7.12e-06	182	113	6	d0e3663f7d39f22a3ebd7fde56ab3504773598f4
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	PDE3A INPP4B FRY SVIL EXOC6B HS6ST3	7.58e-06	184	113	6	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 PDE3A INPP4B EDNRA FRY HS6ST3	7.82e-06	185	113	6	7092436b4db90289516ed130ade596e3021cffaf
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 PDE3A INPP4B EDNRA FRY HS6ST3	7.82e-06	185	113	6	51dfe6ac7df8b330343b37e3bee71e5c65267189
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 PDE3A INPP4B EDNRA FRY HS6ST3	7.82e-06	185	113	6	a8ca7819066d5297ef6966e7f3e2c9f8a7673fdc
ToppCell	COVID-19-Fibroblasts-Pericytes\|COVID-19 / group, cell type (main and fine annotations)	ARHGAP42 PDE3A INPP4B EDNRA PLCB1 AGAP1	7.82e-06	185	113	6	4905adaeeffd353e089578e5ea614437dbe794e6
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 PDE3A INPP4B EDNRA FRY HS6ST3	7.82e-06	185	113	6	a8c02cec3c414f3a0da9f2d6d28ce563b0030705
ToppCell	pdx\|World / Sample and Cell Type and Tumor Cluster (all cells)	RPS6KA3 HECTD4 HS6ST1 EXOC6B PLCB1 AGAP1	8.06e-06	186	113	6	de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCell	pdx-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	RPS6KA3 HECTD4 HS6ST1 EXOC6B PLCB1 AGAP1	8.06e-06	186	113	6	0b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 PDE3A INPP4B EDNRA HS6ST3 DNAH11	8.31e-06	187	113	6	ec4b694487cc446999c7b27b119950a4f252c4b3
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 PDE3A INPP4B EDNRA HS6ST3 DNAH11	8.31e-06	187	113	6	530e4e6d91b5c0d9aa4543caa2b734a1674c5788
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ARHGAP42 PDE3A INPP4B EDNRA PLCB1 AGAP1	8.57e-06	188	113	6	ee151792c7ac9afe820f1a281c6dab383799f358
ToppCell	Mesenchymal-pericyte_cell\|World / Lineage, Cell type, age group and donor	ARHGAP42 PDE3A INPP4B EDNRA PLCB1 AGAP1	8.83e-06	189	113	6	d7ed96add29f219183c802895fbff519b627f635
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_1-Pericyte\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ARHGAP42 PDE3A INPP4B EDNRA PLCB1 AGAP1	9.10e-06	190	113	6	4eb92aef1ee868f4537483d19014d947b7684612
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 PDE3A INPP4B EDNRA HS6ST3 DNAH11	9.10e-06	190	113	6	5681c211baeed4af82a2bbc13420f6a7b487581c
ToppCell	COVID-19-Heart-EC_3\|Heart / Disease (COVID-19 only), tissue and cell type	TCN2 DOCK9 TMTC2 LYST LDB2 PLCB1	9.10e-06	190	113	6	78e7c502b0450c0b37652b1896a2a752fd8a2111
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ARHGAP42 PDE3A INPP4B EDNRA FRY PLCB1	9.10e-06	190	113	6	d6b3a92119b210974a32af3fe9875d60eb02761e
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ARHGAP42 PDE3A INPP4B EDNRA PLCB1 AGAP1	9.10e-06	190	113	6	7be4341e2909101d756f14031c21e705eb45e69a
ToppCell	Mesenchymal-vascular_smooth_muscle_cell\|World / Lineage, Cell type, age group and donor	ARHGAP42 PDE3A INPP4B EDNRA FRY PLCB1	9.38e-06	191	113	6	fd89fbc62aa1c73e0f659991e3bd726a0c97bd68
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 PDE3A INPP4B EDNRA FRY HS6ST3	9.38e-06	191	113	6	7b0d42a877540dbb346a76a62403e0d5d3e07fa6
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 PDE3A INPP4B EDNRA FRY HS6ST3	9.38e-06	191	113	6	cd854b9c426924fdc84bf7f411f6dea447143e79
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 PDE3A INPP4B EDNRA HS6ST3 DNAH11	9.66e-06	192	113	6	24e2f15f5767a97eb3b389922bcfd7b13805e1ce
ToppCell	facs-Lung-Endomucin_-18m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A TCN2 DOCK9 TMTC2 LDB2 PLEC	9.66e-06	192	113	6	ba3fe97786564dba1c8185f2802ce1b57f4f3cc9
ToppCell	facs-Lung-Endomucin_\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A TCN2 DOCK9 TMTC2 LDB2 PLEC	9.66e-06	192	113	6	85d4d0df701451daf95e94a87a0096da1e86533b
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Vein\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	KLHL1 DOCK9 TMTC2 LRRC4C LDB2 PLCB1	9.66e-06	192	113	6	81baf1c4063469bb0c03a8602b40e387ba7b0dfb
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 PDE3A INPP4B EDNRA LDB2 HS6ST3	9.95e-06	193	113	6	f1199518c3626fd29bfce65070dd21a660671213
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-endothelial_cell_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A TCN2 DOCK9 TMTC2 LDB2 PLEC	9.95e-06	193	113	6	2218833749576ba1a0fc95bd155c781e7e1163c6
ToppCell	3'-GW_trimst-1-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LDB2 FAM78A FRY MFNG MADCAM1 IPO11	9.95e-06	193	113	6	0f2967afbbf4e538b63f985c0acc2e5d9aab7589
ToppCell	facs-Lung-Endomucin_-18m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A TCN2 DOCK9 TMTC2 LDB2 PLEC	1.02e-05	194	113	6	df56e23f1dcf1902d29392fcc947e0e268e1648b
ToppCell	COVID-19-lung-Pericytes/_Smooth_Muscle\|lung / Disease (COVID-19 only), tissue and cell type	ARHGAP42 PDE3A INPP4B EDNRA FRY PLCB1	1.02e-05	194	113	6	5e1e0513a54ec4cf0b247ec85c9fbc68dfac1da3
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 PDE3A INPP4B EDNRA LDB2 HS6ST3	1.06e-05	195	113	6	d9a5c75d31c6e8bb1e1ab7fd115ac5deb5fb1c8d
ToppCell	proximal-Hematologic-Proliferating_Macrophage\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KNTC1 CHEK1 PNPLA1 BUB1B PARPBP PLK1	1.12e-05	197	113	6	0b1fa881abbfcc54b322fc27124db3f8947af016
ToppCell	proximal-3-Hematologic-Proliferating_Macrophage\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KNTC1 CHEK1 PNPLA1 BUB1B PARPBP PLK1	1.12e-05	197	113	6	0dd9058aa19d1268ebba9a65555870224b5a5978
ToppCell	proximal-Hematologic-Proliferating_Macrophage-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KNTC1 CHEK1 PNPLA1 BUB1B PARPBP PLK1	1.12e-05	197	113	6	9243617b307acf3df40d93c41cd8d4788699a7ea
ToppCell	COVID-19_Moderate-T/NK_proliferative\|World / disease group, cell group and cell class	KNTC1 PAQR4 CHEK1 BUB1B PARPBP PLK1	1.15e-05	198	113	6	bf0131fbca6032e1aab4aa807f8c1d3be689cb7f
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ARHGAP42 PDE3A INPP4B EDNRA SVIL PLCB1	1.15e-05	198	113	6	c9c96066c7fa897b583657f0b77ea093920ae9ba
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	KNTC1 PAQR4 CHEK1 BUB1B PARPBP PLK1	1.18e-05	199	113	6	11c3d9fe811a4619347f47d2b0e94066e3085625
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	KNTC1 PAQR4 CHEK1 BUB1B PARPBP PLK1	1.18e-05	199	113	6	e98ff036d04fc78dffef156bdc0d644532274067
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	KNTC1 PAQR4 CHEK1 BUB1B PARPBP PLK1	1.18e-05	199	113	6	36c80907b2ec1cbcd1b4e841e6c02a4792591d74
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	KNTC1 PAQR4 CHEK1 BUB1B PARPBP PLK1	1.18e-05	199	113	6	bf4c31902ae8358215245a2e11b5a2fe4ca1bc8c
ToppCell	COVID-19_Mild-Lymphoid_T/NK-T/NK_proliferative\|COVID-19_Mild / Disease group, lineage and cell class	KNTC1 PAQR4 CHEK1 BUB1B PARPBP PLK1	1.18e-05	199	113	6	ddea0e5c1cb6a096ab8e09a8c3c37c1bff381d9c
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	KNTC1 PAQR4 CHEK1 BUB1B PARPBP PLK1	1.18e-05	199	113	6	7feedb0bf84a3361c8ab5b6674ff64e8ff140c23
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	KNTC1 PAQR4 CHEK1 BUB1B PARPBP PLK1	1.18e-05	199	113	6	7beb0e07a27fea94674f24eb61c381b0de38ed3e
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	KNTC1 PAQR4 CHEK1 BUB1B PARPBP PLK1	1.18e-05	199	113	6	123fbf2122aa221d8cbf3aef9361ba0982c07695
ToppCell	COVID-19_Mild-T/NK_proliferative\|COVID-19_Mild / Disease condition and Cell class	KNTC1 PAQR4 CHEK1 BUB1B PARPBP PLK1	1.18e-05	199	113	6	9f9a88d2b099646c1e1a7ee3f8d39cb1a2498ad7
ToppCell	COVID-19_Severe-Lymphoid_T/NK-T/NK_proliferative\|COVID-19_Severe / Disease group, lineage and cell class	KNTC1 PAQR4 CHEK1 BUB1B PARPBP PLK1	1.18e-05	199	113	6	ddae7fe7633661f15d3c79f5187415ffbfecce67
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Vein\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	KLHL1 TMTC2 LRRC4C LDB2 PLCB1 PLEC	1.18e-05	199	113	6	cfb624c7728046fc7f3ef071f57e4d7b013f3fef
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	KNTC1 PAQR4 CHEK1 BUB1B PARPBP PLK1	1.18e-05	199	113	6	6b1304417cf9c44ca70d2bfc2b5acc1a206f25b6
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-T/NK_proliferative\|COVID-19_Mild / Disease, condition lineage and cell class	KNTC1 PAQR4 CHEK1 BUB1B PARPBP PLK1	1.22e-05	200	113	6	6126a3bbafe2110fba0c1c4493035df4e8193d22
ToppCell	mLN-T_cell-cycling_gd_T\|mLN / Region, Cell class and subclass	PAQR4 CHEK1 LDB2 BUB1B PLK1 CFAP46	1.22e-05	200	113	6	4efeef51f885ee8f6dd3911a536cc49e3c14da98
ToppCell	mLN-(1)_T_cell-(18)_cycling_gd_T\|mLN / shred on region, Cell_type, and subtype	PAQR4 CHEK1 LDB2 BUB1B PLK1 CFAP46	1.22e-05	200	113	6	e8a0a88a8344e80783931115bbe6cd5b62a4c1f7
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_activated\|COVID-19_Mild / Disease, condition lineage and cell class	PIM2 DOCK9 OAS1 INPP4B MDN1 CCR7	1.22e-05	200	113	6	d9e8a0d047d4403fb7265fde7448e23a7780785c
ToppCell	Substantia_nigra-Macroglia-OLIGODENDROCYTE-O1-Tfr-Oligodendrocyte.Tfr.Slco3a1_(Slco3a1)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ENPP3 CLDN8 FSIP2 TDRD6	4.00e-05	75	113	4	574ed1836f6bf5fa38a53af0a05fa4437f68f36b
ToppCell	Substantia_nigra-Macroglia-OLIGODENDROCYTE-O1-Tfr-Oligodendrocyte.Tfr.Slco3a1_(Slco3a1)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ENPP3 CLDN8 FSIP2 TDRD6	4.00e-05	75	113	4	45f7861bfeb1c6371b73cf2ea527801342e534bc
ToppCell	Thalamus-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Klk6_(Klk6)\|Thalamus / BrainAtlas - Mouse McCarroll V32	ENPP3 SYS1 CLDN8 TDRD6	4.43e-05	77	113	4	4d6e2486dd7702c4e0115567dd0a2c16617816aa
ToppCell	Thalamus-Macroglia-OLIGODENDROCYTE-O2-Trf-Oligodendrocyte.Trf.Klk6_(Klk6)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	ENPP3 SYS1 CLDN8 TDRD6	4.43e-05	77	113	4	ddd54a5ef6a1fc8be1e852c2192204a749b819c1
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P4-Tnr-Polydendrocyte.Tnr.Dlx1_(Dlx1)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	KNTC1 CHEK1 BUB1B PARPBP PLK1	4.45e-05	153	113	5	d7635f3d4831c02a94f53afc674847d5b51453be
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P4-Tnr\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	KNTC1 CHEK1 BUB1B PARPBP PLK1	4.45e-05	153	113	5	54a941950bbb848077c7bd5726da9e4b3244bd38
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P4\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	KNTC1 CHEK1 BUB1B PARPBP PLK1	4.45e-05	153	113	5	69a8550418ba0fc908a84b3b85761abb6e8ca4c0
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P4-Tnr-Polydendrocyte.Tnr.Dlx1_(Dlx1)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	KNTC1 CHEK1 BUB1B PARPBP PLK1	4.45e-05	153	113	5	e50d20f9e553b8c3e10e187770d8abe1a43d109e
ToppCell	PND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CHEK1 BUB1B CCR7 PARPBP PLK1	4.59e-05	154	113	5	f78b01c19afcbab6319f61e4d6023ecb3d510d24
ToppCell	Control-Epithelial_airway-Ciliated_cells-Ciliated\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	XKR9 CLDN8 KIF19 CFAP46 DNAH11	4.59e-05	154	113	5	4e3bc24043144143842627cacf6f90dda2228910
ToppCell	LPS-IL1RA+antiTNF-Unknown-Endothelial-Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CLTCL1 HARBI1 LIG3 MDN1 TARBP1	4.59e-05	154	113	5	16fdafb5c64d2db321554f87129a962d113f1668
ToppCell	Control-Epithelial_airway-Ciliated_cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	XKR9 CLDN8 KIF19 CFAP46 DNAH11	4.59e-05	154	113	5	7556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-1\|TCGA-Kidney / Sample_Type by Project: Shred V9	ARHGAP42 UBTFL6 ENPP3 DARS1 LDB2	5.67e-05	161	113	5	6cacae4a759ace763597ee394cff498dc5d96f74
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma\|TCGA-Brain / Sample_Type by Project: Shred V9	RYR1 MDN1 PLCB1 PHLPP1 PLEC	5.67e-05	161	113	5	347edb0de10850b7d16c40945751033289289c9b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 PDE3A INPP4B EDNRA HS6ST3	6.37e-05	165	113	5	4f83ac71efc57be3668d8db1e62bad05dc6a5e2b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGAP42 PDE3A INPP4B EDNRA HS6ST3	6.37e-05	165	113	5	cd8de98af8a1a8a6c81d71fae807cc07f319f4c9
ToppCell	356C-Epithelial_cells-Epithelial-D_(AT2)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	ARHGEF5 HARBI1 POLR3B FZD5 SLC27A5	6.55e-05	166	113	5	2e4cb4056e6b0c43290a5588ff525f5f05b8beee
ToppCell	356C-Epithelial_cells-Epithelial-D_(AT2)\|356C / Donor, Lineage, Cell class and subclass (all cells)	ARHGEF5 HARBI1 POLR3B FZD5 SLC27A5	6.55e-05	166	113	5	eb8d972326a734549675307e411fc795af66da70
ToppCell	343B-Myeloid-Dendritic-cDC_proliferating_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	CHEK1 BUB1B PLCB1 PARPBP PLK1	6.74e-05	167	113	5	3461d14e36f09ddc6ee5549ca4797e16d3f37fcc
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Rln3_(parabrachial_pigmented_nucleus_(PBP))-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	REC114 MC4R RYR1 LHCGR	7.48e-05	88	113	4	b4620e79ea80681305434707e87cb02a7c6a5e4f
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Rln3_(parabrachial_pigmented_nucleus_(PBP))--\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	REC114 MC4R RYR1 LHCGR	7.48e-05	88	113	4	7992f8e621edf464bffcb70a6cc5f3b60c1d96f8
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Rln3_(parabrachial_pigmented_nucleus_(PBP))\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	REC114 MC4R RYR1 LHCGR	7.48e-05	88	113	4	b7b55f51af8ffa82813a4747580985a430da9ed1
ToppCell	Control-Fibroblasts-Pericytes\|Control / group, cell type (main and fine annotations)	ARHGAP42 PDE3A INPP4B EDNRA PLCB1	7.54e-05	171	113	5	080003f698f867935c2bfc55d241d3650f45a0ab
ToppCell	droplet-Trachea-3m-Hematologic-myeloid-granulocyte-\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KNTC1 PNPLA1 BUB1B PLK1 NCKAP1L	7.54e-05	171	113	5	41932c9e70829ee3d55ca5fdb74d290fc8229416
ToppCell	368C-Endothelial_cells-Endothelial-B_(Artery)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	DOCK9 LDB2 ITPR1 FCSK FRY	7.96e-05	173	113	5	ec88e871b49331fca59bc610a8ae58e2d5e76bc1
ToppCell	356C-Lymphocytic-CD4_T-cell-Treg_cell_1\|356C / Donor, Lineage, Cell class and subclass (all cells)	PIM2 KLHDC7B INPP4B FCSK MTOR	7.96e-05	173	113	5	e3cb7c8c09f937da6b8d673e9adfec5d94a15548
ToppCell	368C-Endothelial_cells-Endothelial-B_(Artery)\|368C / Donor, Lineage, Cell class and subclass (all cells)	DOCK9 LDB2 ITPR1 FCSK FRY	7.96e-05	173	113	5	22200fe74e33e2beae0eed289ca8476bbc0b1b2d
ToppCell	343B-Myeloid-Dendritic-cDC_proliferating_2\|343B / Donor, Lineage, Cell class and subclass (all cells)	PAQR4 CHEK1 BUB1B PARPBP PLK1	8.18e-05	174	113	5	a75ba49ccea6bd3d78ada1092b46deb5202c58a5
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Macrophage-macrophage,_alveolar-Macro_c1-C1QC\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	UBR4 KLHDC7B FAM78A MDN1 TDRD6	8.18e-05	174	113	5	d77fa525d5c87c190b4a10787b270eabd16c610f
ToppCell	droplet-Lung-21m-Hematologic-myeloid-myeloid_dendritic_cell-proliferating_dendritic\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CHEK1 RYR1 BUB1B PARPBP PLK1	8.40e-05	175	113	5	73f25bd54309aed1480ddc44bdab518b17e71f92
ToppCell	T_cells-ISG-high_CD4+_T_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	OTOA PIM2 OAS1 NAA25 CCR7	9.35e-05	179	113	5	af35ef8a7768cee0c2af0590e5bec35cee6a4714
ToppCell	facs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A INPP4B EDNRA FRY SMARCD3	9.35e-05	179	113	5	8da6863edc756540bb097cc7221c1408640d9bb4
ToppCell	COVID-19-kidney-vSMC/Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ARHGAP42 PDE3A EDNRA FRY HS6ST3	9.35e-05	179	113	5	111b1084f73306bdeffaaf240e7dbb4f5bf33de1
ToppCell	facs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PDE3A INPP4B EDNRA FRY SMARCD3	9.35e-05	179	113	5	f39c13c99a07d009cc677e363ffe089089c64916
ToppCell	droplet-Spleen-nan-3m-Lymphocytic-immature_NKT_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KNTC1 PAQR4 CHEK1 PLK1 TARBP1	9.35e-05	179	113	5	54621d2b3a66e62aa76b7e444118878ed97c1e02
Drug	Naproxen [22204-53-1]; Up 200; 17.4uM; PC3; HT_HG-U133A	PDS5B PIM2 MED13L EDNRA PEX26 MFNG MDN1 IKBKB AGAP1	6.22e-07	197	113	9	1828_UP
Drug	AC1Q7BER	RYR1 ITPR1 ITPR3	2.36e-06	6	113	3	CID000005702
Drug	[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate	RYR1 ITPR1 ITPR3	4.11e-06	7	113	3	CID009547999
Drug	Br2BAPTA	RYR1 ITPR1 ITPR3	4.11e-06	7	113	3	CID003081001
Drug	basic copper carbonate	ITPR1 ITPR3 SPEN	6.55e-06	8	113	3	CID000025503
Drug	R 478	RYR1 ITPR1 ITPR3	1.91e-05	11	113	3	CID000084223
Drug	8-amino-cADPR	RYR1 ITPR1 ITPR3	1.91e-05	11	113	3	CID003081323
Drug	Isocaffeine	ITPR1 ITPR3	2.44e-05	2	113	2	CID000001326
Drug	adenophostin B	ITPR1 ITPR3	2.44e-05	2	113	2	CID000656722
Drug	benzene 1,2,4-trisphosphate	ITPR1 ITPR3	2.44e-05	2	113	2	CID000192376
Drug	AC1L98DX	RYR1 ITPR1 ITPR3 MADCAM1	3.73e-05	38	113	4	CID000439957
Drug	NAADP	RYR1 ITPR1 ITPR3 MTOR	4.14e-05	39	113	4	CID000123952
Drug	alumanylidyneoxidanium	LYST GSTT1 CCR7	4.16e-05	14	113	3	CID000518957
Disease	Sarcomatoid Renal Cell Carcinoma	DNHD1 INPP4B RYR1 GSTT1 MTOR	1.26e-04	128	111	5	C1266043
Disease	Chromophobe Renal Cell Carcinoma	DNHD1 INPP4B RYR1 GSTT1 MTOR	1.26e-04	128	111	5	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	DNHD1 INPP4B RYR1 GSTT1 MTOR	1.26e-04	128	111	5	C1266044
Disease	Papillary Renal Cell Carcinoma	DNHD1 INPP4B RYR1 GSTT1 MTOR	1.26e-04	128	111	5	C1306837
Disease	Renal Cell Carcinoma	DNHD1 INPP4B RYR1 GSTT1 MTOR	1.26e-04	128	111	5	C0007134
Disease	retinal vasculature measurement	PDS5B PDE3A TMTC2 LRRC4C MED13L ITPR1 FRY POLR3B PLCB1	1.51e-04	517	111	9	EFO_0010554
Disease	obesity (implicated_via_orthology)	MC4R MED13L ITPR1 ITPR3 PNPLA1 PLCB1	1.67e-04	215	111	6	DOID:9970 (implicated_via_orthology)
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	DNHD1 INPP4B RYR1 GSTT1 MTOR	2.48e-04	148	111	5	C0279702
Disease	muscular atrophy (implicated_via_orthology)	MTOR IKBKB	2.91e-04	7	111	2	DOID:767 (implicated_via_orthology)
Disease	coronary artery calcification	PDE3A XKR9 ENPP3 MED13L FSIP2 FRY SLC25A52 AGAP1	3.09e-04	450	111	8	EFO_0004723
Disease	lymphocyte count	HECTD4 SPPL3 MED13L TRIP12 LYST OR10X1 INPP4B EDNRA ITPR1 HS6ST1 PLCB1 PHLPP1 CCR7 PLEC AGAP1	3.89e-04	1464	111	15	EFO_0004587
Disease	Malignant neoplasm of breast	RPS6KA3 UBR4 CHEK1 INPP4B EDNRA CUL5 LHCGR NAA25 MTOR PLCB1 IKBKB SPEN	7.32e-04	1074	111	12	C0006142
Disease	autosomal dominant cerebellar ataxia (implicated_via_orthology)	ITPR1 ITPR3	9.03e-04	12	111	2	DOID:1441 (implicated_via_orthology)
Disease	Charcot-Marie-Tooth disease (is_implicated_in)	ITPR3 POLR3B	9.03e-04	12	111	2	DOID:10595 (is_implicated_in)
Disease	AL amyloidosis	SMARCD3 DNAH11	9.03e-04	12	111	2	MONDO_0019438
Disease	Alzheimer disease, dementia	POLR3B CFAP46	9.03e-04	12	111	2	MONDO_0001627, MONDO_0004975
Disease	systolic blood pressure, alcohol drinking	ARHGAP42 PDE3A HECTD4 NAA25	1.41e-03	128	111	4	EFO_0004329, EFO_0006335
Disease	third ventricle volume measurement	LDB2 LDB1	1.43e-03	15	111	2	EFO_0010335
Disease	Intellectual Disability	PITRM1 TCN2 MED13L FCSK FRY POLR3B MTOR	1.54e-03	447	111	7	C3714756
Disease	myocardial infarction (implicated_via_orthology)	EDNRA RYR1 MTOR	2.00e-03	66	111	3	DOID:5844 (implicated_via_orthology)
Disease	myocardial infarction	ARHGAP42 DOCK9 HECTD4 MC4R EDNRA NAA25	2.13e-03	350	111	6	EFO_0000612
Disease	portal hypertension (implicated_via_orthology)	EDNRA MTOR	2.30e-03	19	111	2	DOID:10762 (implicated_via_orthology)
Disease	thrombin activatable fibrinolysis inhibitor activation peptide measurement	OTOA ITPR1	2.30e-03	19	111	2	EFO_0008582
Disease	obesity (biomarker_via_orthology)	PDE3A MC4R GSTT1 MTOR	2.34e-03	147	111	4	DOID:9970 (biomarker_via_orthology)
Disease	Severe Combined Immunodeficiency	TCN2 JAK3	2.55e-03	20	111	2	C0085110
Disease	parental longevity	ARHGAP42 PDE3A HECTD4 LRRC4C NAA25 PHLPP1 HS6ST3	2.69e-03	494	111	7	EFO_0007796
Disease	lung disease (is_implicated_in)	EDNRA GSTT1	3.08e-03	22	111	2	DOID:850 (is_implicated_in)
Disease	QRS duration, response to sulfonylurea	DOCK9 MDN1	3.37e-03	23	111	2	EFO_0005055, EFO_0007922
Disease	DNA methylation	ARHGAP42 DNHD1 LRRC4C FRY MDN1 SVIL PLCB1 DNAH11	3.40e-03	656	111	8	GO_0006306
Disease	Myopia	PDE3A KLHL1 DOCK9 LRRC4C MED13L EXOC6B	3.41e-03	385	111	6	HP_0000545
Disease	Cleft Palate	INTS1 MED13L EDNRA	3.57e-03	81	111	3	C0008925
Disease	Anhedonia	MC4R CCR7	3.67e-03	24	111	2	C0178417

Protein segments in the cluster

Peptide	Gene	Start	Entry
LKLGRLCNEPLDMYS	BUB1B	126	O60566
LGLAPDMFFCLRLLE	GPT	431	P24298
LLQYGCPDERFVLMA	AGAP1	821	Q9UPQ3
ELLANYCDMLLRKTP	CUL5	406	Q93034
ERLLNKMCGTLPYVA	CHEK1	161	O14757
ALAMPREELDLLECY	ARHGEF5	1496	Q12774
LAITYGLLEECGLRM	GSDMC	461	Q9BYG8
FSGMLLLLCISIDRY	CCR7	141	P32248
LRLFLSRPAECQDML	AP4B1	481	Q9Y6B7
ELMLELLECYLQAGR	CFAP46	176	Q8IYW2
LCRVYLEEFMNPSLT	DNAH11	4156	Q96DT5
CELLSFLLLMDYIGI	EDNRA	341	P25101
CMRILGEFRSYLPLL	DNHD1	1076	Q96M86
PDYVLCSPEMQERLL	ALDH3B2	166	P48448
AEELGPFLRLCLMDQ	REC114	231	Q7Z4M0
SRLRLPLEYMAICAL	PDS5B	931	Q9NTI5
CLGESLARMELFLYL	CYP2F1	436	P24903
QSLRLVMEYLPSGCL	JAK3	896	P52333
VMEYLPSGCLRDFLQ	JAK3	901	P52333
LASKPLCVLYMENDL	PARPBP	451	Q9NWS1
NDISPLCKYRMDLVL	ITPR3	1976	Q14573
MLGLLVCFYNDLELL	OTOA	341	Q7RTW8
PMYLFLCLLSLTDLA	OR52D1	61	Q9H346
TNCIILTLMGYDRFL	OR10X1	126	Q8NGY0
LTLMGYDRFLAICNP	OR10X1	131	Q8NGY0
ACPTREQLLMNALLY	MDN1	3491	Q9NU22
LLDCLADYIMERVGL	H2AP	56	O75409
NPCEDIMGYDFLRVL	LHCGR	351	P22888
ALYCQATMRLPGLEL	MADCAM1	201	Q13477
LSLMRCYTEMLDNLP	MED13L	1701	Q71F56
NYLRLCVILEPMQEL	LDB1	241	Q86U70
ETPLYILCTAGMRLL	ENTPD7	166	Q9NQZ7
LPLLAMEYCQGGDLR	IKBKB	91	O14920
CLGLMQERKEPQYLE	INTS1	516	Q8N201
LRCMSDENLPYDLRA	ITPR1	766	Q14643
KQLRAENGLLMTPCY	RPS6KA3	566	P51812
LLQELAYSLPQCLML	INPP4B	606	O15327
AYSLPQCLMLTLRRD	INPP4B	611	O15327
DLRPMLYEAICNLLQ	IPO11	511	Q9UI26
LNYLRLCVILEPMQE	LDB2	201	O43679
DILASPLLTCIYDML	FSIP2	1351	Q5CZC0
MAIPITVLDCDLLLY	HARBI1	1	Q96MB7
AMAYDRLLAICQPLT	OR3A2	126	P47893
AMAYDRLLAICQPLT	OR3A3	126	P47888
CLSGNIPALELMALY	PDE3A	816	Q14432
LELCILLYSKMQEPG	PEX26	121	Q7Z412
CRAFPPLYEDIMSLL	INTS2	1111	Q9H0H0
LAICGIEMDEYLRVL	PNPLA1	61	Q8N8W4
LDMLESCFPYVLLRN	NCKAP1L	1101	P55160
YIQLELPAFALACLM	KNTC1	2066	P50748
YLNLAMCNLREIPNL	LRRC4C	201	Q9HCJ2
LCLPVLEMYSKLRDQ	EXOC6B	136	Q9Y2D4
IEDYLLPDTCFRMQI	OAS1	16	P00973
DCIYFNDVSLMDRPL	LIG3	596	P49916
LYCRMALLNIFAPKL	HECTD4	2446	Q9Y4D8
MELRTCGLPYINLEF	HECTD4	3861	Q9Y4D8
PQYSSLEIMLEKLRC	HECTD4	3971	Q9Y4D8
VRMLADLSLVGCYNL	HS6ST1	251	O60243
VRMLADLSLVGCYNL	HS6ST3	311	Q8IZP7
GSLPCYLRMDALALL	PAQR4	201	Q8N4S7
EMIRDLLNPSLGYLE	KIF19	156	Q2TAC6
NLDCLLDIMTYRLGP	FCSK	126	Q8N0W3
LPVLGRDAEVLCMDY	FZD5	136	Q13467
LAEYIDMICAILDIP	IFT46	236	Q9NQC8
ALCVRPDVMELDELY	KDM1B	281	Q8NB78
LNDCLREMLLFPYDD	DOCK9	66	Q9BZ29
EVYNLMCDLLRIQPA	ENPP3	516	O14638
LEYLLRLADFMQLCG	CHAC1	176	Q9BUX1
VADMLLDNGLLYVLC	LYST	2461	Q99698
LPEELLLLICSYLDM	FBXW4	31	P57775
IMCNSIIDPLIYALR	MC4R	291	P32245
MSDNLLRVLGDPCLY	KLHDC7B	246	Q96G42
LLSCELARMYPELTL	FRY	1321	Q5TBA9
QSSFDPCMYRELLLV	B3GNT6	341	Q6ZMB0
YAALIDLLGRCAPEM	RYR1	2426	P21817
MALALNRYLCLAVLP	RYR1	2546	P21817
YLPELMECMLQLLRN	IPO4	476	Q8TEX9
LIRLPDDCTMGYIIE	MFNG	226	O00587
PLMYCVLADRLDCAD	INVS	51	Q9Y283
LELQYVSPKLLMCRD	MTOR	2121	P42345
MKQLNYSLLCLPEDI	ALOX15B	446	O15296
MGLELYLDLLSQPCR	GSTT1	1	P30711
FGMLTPALCYLLEEQ	RTL9	1141	Q8NET4
YLCMRTELKEIPLNS	SYS1	136	Q8N2H4
YDVLLLPMQAVRCSL	TDRD6	1086	O60522
ETNCIYRLMDDKLVP	SVIL	1561	O95425
SLEIRALLYAMGCIQ	FAM78A	11	Q5JUQ0
EQSFLLCEDLLYGRM	MPHOSPH6	61	Q99547
GLKNYLRCLAEPLMT	ARHGAP42	456	A6NI28
ILLYDMVCGDIPFER	PIM2	226	Q9P1W9
VLFSSLCLDRNLPDM	PITRM1	666	Q5JRX3
LSVRCTLLLMLDYQP	SMARCD3	246	Q6STE5
EPTLRLEYCEALAML	DARS1	341	P14868
ALMFGLYEDLSCLLR	SLC25A52	96	Q3SY17
YLCEKRIDMVPELLS	DIS3	531	Q9Y2L1
PLMLLLQLDYCASNV	OR6C3	156	Q9NZP0
YIDLIFPDCLAPRVM	TCN2	301	P20062
RMQCKIYDSLLALSP	CLDN8	61	P56748
FTCYDLLRPDMVLEL	CLTCL1	1571	P53675
LMDCILALPRFYQAS	SPG11	2321	Q96JI7
DILRLLECMENNLPY	UBTFL6	21	P0CB48
RMTVETDYCLLLALP	SPEN	3566	Q96T58
CLLRMLSPFELVQFD	SLC27A5	456	Q9Y2P5
ALLCRELRPLGAYMS	STOML1	361	Q9UBI4
DIVMPGLLLCFVLRY	SPPL3	271	Q8TCT6
ERVLYIPSMGFCLLI	TMTC2	421	Q8N394
ERDCLIGYGASMLLL	POLR3B	1051	Q9NW08
LTYLQLMERCITDPQ	PLEC	4236	Q15149
EYCRLIFGDALLMEP	PLCB1	426	Q9NQ66
LVLLNPYAALCNRML	TTC36	161	A6NLP5
EVPYLLQCTMSDILA	PHLPP1	1216	O60346
AYMPLLKTDRCLQLL	TARBP1	681	Q13395
PQELYELTSLICELM	TRIP12	721	Q14669
ILLCEDGSLRIYMAN	UBR4	2231	Q5T4S7
ERIEACLPLYTNMIA	ZFC3H1	1596	O60293
EYLMPFLLNQCGSLL	TMEM234	56	Q8WY98
LSMLRLFETYLEGCP	XKR9	131	Q5GH70
LILCPLMAAVTYIDE	PLK1	541	P53350
CNDLSMLLAFIRLPL	KLHL1	391	Q9NR64
LLVRIYCMLGAFEPV	NAA25	511	Q14CX7