Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	fn3	BOC PRTG IL31RA FN1 TNC MYOM3 OBSCN CMYA5 TEK PTPRD CSF3R USH2A SDK1	1.41e-10	162	133	13	PF00041
Domain	FN3	BOC PRTG IL31RA FN1 TNC MYOM3 OBSCN CMYA5 TEK PTPRD CSF3R USH2A SDK1	7.34e-10	185	133	13	SM00060
Domain	FN3	BOC PRTG IL31RA FN1 TNC MYOM3 OBSCN CMYA5 TEK PTPRD CSF3R USH2A SDK1	1.80e-09	199	133	13	PS50853
Domain	FN3_dom	BOC PRTG IL31RA FN1 TNC MYOM3 OBSCN CMYA5 TEK PTPRD CSF3R USH2A SDK1	3.26e-09	209	133	13	IPR003961
Domain	-	BOC PLXNA3 PRTG IL31RA FN1 TNC MYOM3 OBSCN CMYA5 TEK PTPRD CSF3R NCR2 USH2A SDK1 ALPK2 LILRA4	4.89e-06	663	133	17	2.60.40.10
Domain	Ig-like_fold	BOC PLXNA3 PRTG IL31RA FN1 TNC MYOM3 OBSCN CMYA5 TEK PTPRD CSF3R NCR2 USH2A SDK1 ALPK2 LILRA4	1.11e-05	706	133	17	IPR013783
Domain	EGF_1	FN1 TNC LAMB2 TEK F12 BMP1 TLL2 USH2A IMPG2	8.94e-05	255	133	9	PS00022
Domain	BMP_1/tolloid-like	BMP1 TLL2	1.50e-04	3	133	2	IPR015446
Domain	CPT_N	CPT1A CPT1B	1.50e-04	3	133	2	IPR032476
Domain	CPT_N	CPT1A CPT1B	1.50e-04	3	133	2	PF16484
Domain	IGc2	BOC PRTG MYOM3 OBSCN PTPRD SDK1 ALPK2 LILRA4	2.83e-04	235	133	8	SM00408
Domain	Ig_sub2	BOC PRTG MYOM3 OBSCN PTPRD SDK1 ALPK2 LILRA4	2.83e-04	235	133	8	IPR003598
Domain	FN1_2	FN1 F12	2.99e-04	4	133	2	PS51091
Domain	fn1	FN1 F12	2.99e-04	4	133	2	PF00039
Domain	Fibronectin_type1	FN1 F12	2.99e-04	4	133	2	IPR000083
Domain	FN1	FN1 F12	2.99e-04	4	133	2	SM00058
Domain	FN1_1	FN1 F12	2.99e-04	4	133	2	PS01253
Domain	Ig_I-set	BOC PRTG MYOM3 OBSCN PTPRD SDK1 ALPK2	4.27e-04	190	133	7	IPR013098
Domain	I-set	BOC PRTG MYOM3 OBSCN PTPRD SDK1 ALPK2	4.27e-04	190	133	7	PF07679
Domain	Defensin_propep	DEFA1 DEFA3	4.96e-04	5	133	2	PF00879
Domain	Alpha-defensin	DEFA1 DEFA3	4.96e-04	5	133	2	IPR006081
Domain	TMEM132D_N	TMEM132C TMEM132A	4.96e-04	5	133	2	PF15705
Domain	TMEM132D_C	TMEM132C TMEM132A	4.96e-04	5	133	2	PF15706
Domain	TMEM132_M	TMEM132C TMEM132A	4.96e-04	5	133	2	IPR031437
Domain	TMEM132_C	TMEM132C TMEM132A	4.96e-04	5	133	2	IPR031436
Domain	TMEM132_N	TMEM132C TMEM132A	4.96e-04	5	133	2	IPR031435
Domain	Alpha-defensin_pro	DEFA1 DEFA3	4.96e-04	5	133	2	IPR016327
Domain	DEFENSIN	DEFA1 DEFA3	4.96e-04	5	133	2	PS00269
Domain	Defensin_propep	DEFA1 DEFA3	4.96e-04	5	133	2	IPR002366
Domain	TMEM132	TMEM132C TMEM132A	4.96e-04	5	133	2	IPR026307
Domain	TMEM132	TMEM132C TMEM132A	4.96e-04	5	133	2	PF16070
Domain	Defensin_1	DEFA1 DEFA3	4.96e-04	5	133	2	PF00323
Domain	EGF-like_CS	FN1 TNC LAMB2 TEK F12 BMP1 TLL2 IMPG2	5.69e-04	261	133	8	IPR013032
Domain	Peptidase_M12A	BMP1 TLL2	7.41e-04	6	133	2	IPR001506
Domain	Astacin	BMP1 TLL2	7.41e-04	6	133	2	PF01400
Domain	Ig-like_dom	BOC PRTG MYOM3 OBSCN TEK PTPRD CSF3R NCR2 SDK1 ALPK2 LILRA4	9.53e-04	503	133	11	IPR007110
Domain	Carn_acyl_trans	CPT1A CPT1B	1.03e-03	7	133	2	IPR000542
Domain	Carn_acyltransf	CPT1A CPT1B	1.03e-03	7	133	2	PF00755
Domain	ACYLTRANSF_C_1	CPT1A CPT1B	1.03e-03	7	133	2	PS00439
Domain	ACYLTRANSF_C_2	CPT1A CPT1B	1.03e-03	7	133	2	PS00440
Domain	Defensin_beta/alpha	DEFA1 DEFA3	1.37e-03	8	133	2	IPR006080
Domain	DEFSN	DEFA1 DEFA3	1.37e-03	8	133	2	SM00048
Domain	EGF-like_dom	TNC LAMB2 TEK F12 BMP1 TLL2 IMPG2	2.06e-03	249	133	7	IPR000742
Domain	IG_LIKE	BOC PRTG MYOM3 OBSCN TEK PTPRD NCR2 SDK1 ALPK2 LILRA4	2.72e-03	491	133	10	PS50835
Domain	EGF_2	TNC LAMB2 TEK F12 BMP1 TLL2 IMPG2	2.92e-03	265	133	7	PS01186
Domain	OA_transporter	SLCO3A1 SLCO1B1	3.17e-03	12	133	2	IPR004156
Domain	OATP	SLCO3A1 SLCO1B1	3.17e-03	12	133	2	PF03137
Domain	IG	BOC PRTG MYOM3 OBSCN PTPRD NCR2 SDK1 ALPK2 LILRA4	3.21e-03	421	133	9	SM00409
Domain	Ig_sub	BOC PRTG MYOM3 OBSCN PTPRD NCR2 SDK1 ALPK2 LILRA4	3.21e-03	421	133	9	IPR003599
Domain	-	FN1 F12	3.73e-03	13	133	2	2.10.10.10
Domain	FN_type2_col-bd	FN1 F12	4.33e-03	14	133	2	IPR000562
Domain	FN2_2	FN1 F12	4.33e-03	14	133	2	PS51092
Domain	FN2_1	FN1 F12	4.33e-03	14	133	2	PS00023
Domain	fn2	FN1 F12	4.33e-03	14	133	2	PF00040
Domain	FN2	FN1 F12	4.33e-03	14	133	2	SM00059
Domain	ZINC_PROTEASE	BMP1 ADAMTS7 TLL2 KEL	5.30e-03	98	133	4	PS00142
Domain	Laminin_N	LAMB2 USH2A	5.66e-03	16	133	2	IPR008211
Domain	Nicotinic_acetylcholine_rcpt	CHRNA5 CHRNE	5.66e-03	16	133	2	IPR002394
Domain	LamNT	LAMB2 USH2A	5.66e-03	16	133	2	SM00136
Domain	-	PLXNA3 GAPVD1	5.66e-03	16	133	2	1.10.506.10
Domain	LAMININ_NTER	LAMB2 USH2A	5.66e-03	16	133	2	PS51117
Domain	Laminin_N	LAMB2 USH2A	5.66e-03	16	133	2	PF00055
Domain	EGF	TNC LAMB2 TEK F12 BMP1 TLL2	6.78e-03	235	133	6	SM00181
Domain	EGF_3	TNC TEK F12 BMP1 TLL2 IMPG2	6.78e-03	235	133	6	PS50026
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	VWA5B2 CCDC71L PLXNA3 MYOM3 OBSCN LAMB2 CC2D1A EDC4 CLDN23 DHX30 FANCA PCNX2 NHSL1 NCOR1 C2CD3 RPAP1 ADAMTS7 TMEM132A ZFYVE26 SNX11	1.43e-08	1105	137	20	35748872
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	GAPVD1 CEP85 EMC1 DCAF8 LEMD3 GPS1 LAMB2 CC2D1A CPT1A KANK2 AAR2 PTPRD RPAP1 PKP3 SMS PRRC2A	1.59e-06	974	137	16	28675297
Pubmed	Identification of binding partners interacting with the α1-N-propeptide of type V collagen.	FN1 TNC BMP1	2.07e-06	7	137	3	20979576
Pubmed	Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.	DCHS2 CEP85 ACD SLCO3A1 TACC2 CPT1A LGSN SP110 CLDN23 TUBGCP6 PTPRD RP1L1 SDK1 TMEM18	4.40e-06	814	137	14	23251661
Pubmed	Neutrophil defensins enhance lung epithelial wound closure and mucin gene expression in vitro.	DEFA1 DEFA3	1.54e-05	2	137	2	12871849
Pubmed	Variants within the muscle and liver isoforms of the carnitine palmitoyltransferase I (CPT1) gene interact with fat intake to modulate indices of obesity in French-Canadians.	CPT1A CPT1B	1.54e-05	2	137	2	17089095
Pubmed	Association of SLCO1B1 and ABCB1 Genetic Variants with Atorvastatin-induced Myopathy in Patients with Acute Ischemic Stroke.	SLCO1B1 ABCB1	1.54e-05	2	137	2	31298164
Pubmed	SLCO1B1 and ABCB1 variants synergistically influence the atorvastatin treatment response in South Indian coronary artery disease patients.	SLCO1B1 ABCB1	1.54e-05	2	137	2	35968761
Pubmed	Human Neutrophil Peptides 1-3--early markers in development of colorectal adenomas and carcinomas.	DEFA1 DEFA3	1.54e-05	2	137	2	18957723
Pubmed	Pharmacokinetics and response to pravastatin in paediatric patients with familial hypercholesterolaemia and in paediatric cardiac transplant recipients in relation to polymorphisms of the SLCO1B1 and ABCB1 genes.	SLCO1B1 ABCB1	1.54e-05	2	137	2	16722833
Pubmed	Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1.	EDC4 BRCA1	1.54e-05	2	137	2	29511213
Pubmed	Salivary levels of HNP 1-3 are related to oral ulcer activity in Behçet's disease.	DEFA1 DEFA3	1.54e-05	2	137	2	22861387
Pubmed	Staphylococcal superantigen-like protein 8 (SSL8) binds to tenascin C and inhibits tenascin C-fibronectin interaction and cell motility of keratinocytes.	FN1 TNC	1.54e-05	2	137	2	23485472
Pubmed	BRCA1 interacts directly with the Fanconi anemia protein FANCA.	FANCA BRCA1	1.54e-05	2	137	2	12354784
Pubmed	Defensins: antimicrobial and cytotoxic peptides of mammalian cells.	DEFA1 DEFA3	1.54e-05	2	137	2	8476558
Pubmed	Counterbalancing anti-adhesive effects of Tenascin-C through fibronectin expression in endothelial cells.	FN1 TNC	1.54e-05	2	137	2	28986537
Pubmed	Highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas.	PRUNE2 OBSCN	1.54e-05	2	137	2	17360660
Pubmed	Localization of human neutrophil peptide (HNP) and its messenger RNA in neutrophil series.	DEFA1 DEFA3	1.54e-05	2	137	2	8080882
Pubmed	Alpha-defensins secreted by dysplastic granulocytes inhibit the differentiation of monocytes in chronic myelomonocytic leukemia.	DEFA1 DEFA3	1.54e-05	2	137	2	19864642
Pubmed	Multidrug-resistant tuberculosis is associated with low plasma concentrations of human neutrophil peptides 1-3.	DEFA1 DEFA3	1.54e-05	2	137	2	21333105
Pubmed	Cleavage of extracellular matrix in periodontitis: gingipains differentially affect cell adhesion activities of fibronectin and tenascin-C.	FN1 TNC	1.54e-05	2	137	2	23313574
Pubmed	Fine chromosome mapping of the genes for human liver and muscle carnitine palmitoyltransferase I (CPT1A and CPT1B).	CPT1A CPT1B	1.54e-05	2	137	2	9070950
Pubmed	Cryptic domains of tenascin-C differentially control fibronectin fibrillogenesis.	FN1 TNC	1.54e-05	2	137	2	20708078
Pubmed	Alpha-defensin overexpression in patients with Bell's palsy and Ramsay Hunt syndrome.	DEFA1 DEFA3	1.54e-05	2	137	2	22737966
Pubmed	Midpregnancy vaginal fluid defensins, bacterial vaginosis, and risk of preterm delivery.	DEFA1 DEFA3	1.54e-05	2	137	2	18757648
Pubmed	Binding of tenascin-C to soluble fibronectin and matrix fibrils.	FN1 TNC	1.54e-05	2	137	2	7499434
Pubmed	alpha-Defensins 1, 2, and 3 are expressed by granulocytes in lymphoid tissues of HIV-1-seropositive and -seronegative individuals.	DEFA1 DEFA3	1.54e-05	2	137	2	16837860
Pubmed	CSF3R T618I mutant chronic myelomonocytic leukemia (CMML) defines a proliferative CMML subtype enriched in ASXL1 mutations with adverse outcomes.	ASXL1 CSF3R	1.54e-05	2	137	2	33707412
Pubmed	Pharmacogenetic interactions between ABCB1 and SLCO1B1 tagging SNPs and the effectiveness of statins in the prevention of myocardial infarction.	SLCO1B1 ABCB1	1.54e-05	2	137	2	20712525
Pubmed	Regulation of neovascularization by human neutrophil peptides (alpha-defensins): a link between inflammation and angiogenesis.	DEFA1 DEFA3	1.54e-05	2	137	2	15208269
Pubmed	Plasma human neutrophil proteins-1, -2, and -3 levels in patients with bladder cancer.	DEFA1 DEFA3	1.54e-05	2	137	2	23011762
Pubmed	Expression of α-defensin 1-3 in T cells from severe cutaneous drug-induced hypersensitivity reactions.	DEFA1 DEFA3	1.54e-05	2	137	2	20880148
Pubmed	Tenascin C, Fibronectin, and Tumor-Stroma Ratio in Pancreatic Ductal Adenocarcinoma.	FN1 TNC	1.54e-05	2	137	2	30451798
Pubmed	Increased alpha-defensins 1-3 production by dendritic cells in HIV-infected individuals is associated with slower disease progression.	DEFA1 DEFA3	1.54e-05	2	137	2	20195543
Pubmed	Prevalence of dyslipidemia and gene polymorphisms of ABCB1 and SLCO1B1 in Han, Uygur, Kazak, Hui, Tatar, Kirgiz, and Sibe populations with coronary heart disease in Xinjiang, China.	SLCO1B1 ABCB1	1.54e-05	2	137	2	34563206
Pubmed	The putative role of human peritoneal adipocytes in the fight against bacteria: synthesis of the antimicrobial active peptide DEFA1-3.	DEFA1 DEFA3	1.54e-05	2	137	2	20424487
Pubmed	Detection of colorectal disease by stool defensin assay: an exploratory study.	DEFA1 DEFA3	1.54e-05	2	137	2	17531545
Pubmed	Cleft palate formation in fetal Br mice with midfacial retrusion: tenascin, fibronectin, laminin, and type IV collagen immunolocalization.	FN1 TNC	1.54e-05	2	137	2	9482226
Pubmed	Expression and regulation of carnitine palmitoyltransferase-Ialpha and -Ibeta genes.	CPT1A CPT1B	1.54e-05	2	137	2	10408760
Pubmed	De novo expression of fetal ED-A(+) fibronectin and B (+) tenascin-C splicing variants in human cardiac allografts: potential impact for targeted therapy of rejection.	FN1 TNC	1.54e-05	2	137	2	24792713
Pubmed	Low-Copy Number Polymorphism in DEFA1/DEFA3 Is Associated with Susceptibility to Hospital-Acquired Infections in Critically Ill Patients.	DEFA1 DEFA3	1.54e-05	2	137	2	29950924
Pubmed	Increased levels of human neutrophil alpha-defensins in chronic venous leg ulcers.	DEFA1 DEFA3	1.54e-05	2	137	2	18472248
Pubmed	Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization.	DEFA1 DEFA3	1.54e-05	2	137	2	2006422
Pubmed	Fibronectin binds and enhances the activity of bone morphogenetic protein 1.	FN1 BMP1	1.54e-05	2	137	2	19617627
Pubmed	The capsule sensitizes Streptococcus pneumoniae to alpha-defensins human neutrophil proteins 1 to 3.	DEFA1 DEFA3	1.54e-05	2	137	2	18474654
Pubmed	Increased levels of alpha-defensin (-1, -2 and -3) in type 1 diabetic patients with nephropathy.	DEFA1 DEFA3	1.54e-05	2	137	2	18003664
Pubmed	Human neutrophil peptides 1-3 as gastric cancer tissue markers measured by MALDI-imaging mass spectrometry: implications for infiltrated neutrophils as a tumor target.	DEFA1 DEFA3	1.54e-05	2	137	2	22297599
Pubmed	Relationship between genetic polymorphism of drug transporters and the efficacy of Rosuvastatin, atorvastatin and simvastatin in patients with hyperlipidemia.	SLCO1B1 ABCB1	1.54e-05	2	137	2	34749751
Pubmed	Changes in extra cellular matrix remodelling and re-expression of fibronectin and tenascin-C splicing variants in human myocardial tissue of the right atrial auricle: implications for a targeted therapy of cardiovascular diseases using human SIP format antibodies.	FN1 TNC	1.54e-05	2	137	2	20232238
Pubmed	An integrated pharmacokinetic/pharmacogenomic analysis of ABCB1 and SLCO1B1 polymorphisms on edoxaban exposure.	SLCO1B1 ABCB1	1.54e-05	2	137	2	27897269
Pubmed	Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis.	CPT1A CPT1B	1.54e-05	2	137	2	9013572
Pubmed	Upregulated expression of human alpha-defensins 1, 2 and 3 in hypercholesteremia and its relationship with serum lipid levels.	DEFA1 DEFA3	1.54e-05	2	137	2	25300997
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	PLXNA3 EMC1 LEMD3 GPS1 SUN1 LAMB2 PGAP4 CPT1A ATP9A CHRNA5 USP19 FANCA BMP1 GLB1 TMEM132A GM2A	2.18e-05	1201	137	16	35696571
Pubmed	Image-based genome-wide siRNA screen identifies selective autophagy factors.	BOC MAP1A OBSCN LARP1B ADAMTS7 CA7	4.17e-05	159	137	6	22020285
Pubmed	Differentiation stage-specific expression of a gene during granulopoiesis.	DEFA1 DEFA3	4.61e-05	3	137	2	2918759
Pubmed	Association between statin-induced creatine kinase elevation and genetic polymorphisms in SLCO1B1, ABCB1 and ABCG2.	SLCO1B1 ABCB1	4.61e-05	3	137	2	24595600
Pubmed	CYP3A5, ABCB1, and SLCO1B1 polymorphisms and pharmacokinetics and virologic outcome of lopinavir/ritonavir in HIV-infected children.	SLCO1B1 ABCB1	4.61e-05	3	137	2	21743379
Pubmed	CYP2C9*3(1075A > C), ABCB1 and SLCO1B1 genetic polymorphisms and gender are determinants of inter-subject variability in pitavastatin pharmacokinetics.	SLCO1B1 ABCB1	4.61e-05	3	137	2	23556337
Pubmed	Relevance of α-defensins (HNP1-3) and defensin β-1 in diabetes.	DEFA1 DEFA3	4.61e-05	3	137	2	25083086
Pubmed	Isolation and characterization of human defensin cDNA clones.	DEFA1 DEFA3	4.61e-05	3	137	2	3174637
Pubmed	Posttranslational processing of defensins in immature human myeloid cells.	DEFA1 DEFA3	4.61e-05	3	137	2	1339298
Pubmed	The FANC/BRCA Pathway Releases Replication Blockades by Eliminating DNA Interstrand Cross-Links.	FANCA BRCA1	4.61e-05	3	137	2	32466131
Pubmed	Effects of tuberculosis, race, and human gene SLCO1B1 polymorphisms on rifampin concentrations.	SLCO1B1 ABCB1	4.61e-05	3	137	2	20660695
Pubmed	Structural basis for the substrate specificity of bone morphogenetic protein 1/tolloid-like metalloproteases.	BMP1 TLL2	4.61e-05	3	137	2	18824173
Pubmed	Role of SLCO1B1, ABCB1, and CHRNA1 gene polymorphisms on the efficacy of rocuronium in Chinese patients.	SLCO1B1 ABCB1	4.61e-05	3	137	2	25279974
Pubmed	CYP3A5 genotype is associated with diagnosis of hypertension in elderly patients: data from the DEBATE Study.	SLCO1B1 ABCB1	4.61e-05	3	137	2	15952872
Pubmed	Expression and activity of ABCG2, but not ABCB1 or OATP1B1, are associated with cholesterol levels: evidence from in vitro and in vivo experiments.	SLCO1B1 ABCB1	4.61e-05	3	137	2	25084202
Pubmed	Influence of genomic ancestry on the distribution of SLCO1B1, SLCO1B3 and ABCB1 gene polymorphisms among Brazilians.	SLCO1B1 ABCB1	4.61e-05	3	137	2	22136368
Pubmed	Genomic structure of and a cardiac promoter for the mouse carnitine palmitoyltransferase II gene.	CPT1A CPT1B	4.61e-05	3	137	2	8307575
Pubmed	Epithelial-mesenchymal interactions in the developing kidney lead to expression of tenascin in the mesenchyme.	FN1 TNC	4.61e-05	3	137	2	2440899
Pubmed	The structure of neutrophil defensin genes.	DEFA1 DEFA3	4.61e-05	3	137	2	8477861
Pubmed	Increased genomic copy number of DEFA1/DEFA3 is associated with susceptibility to severe sepsis in Chinese Han population.	DEFA1 DEFA3	4.61e-05	3	137	2	20502117
Pubmed	Genetic analysis of the role of proteolysis in the activation of latent myostatin.	BMP1 TLL2	4.61e-05	3	137	2	18286185
Pubmed	MRPS18CP2 alleles and DEFA3 absence as putative chromosome 8p23.1 modifiers of hearing loss due to mtDNA mutation A1555G in the 12S rRNA gene.	CLDN23 DEFA3	4.61e-05	3	137	2	18154640
Pubmed	Impact of OATP1B1, MDR1, and CYP3A4 expression in liver and intestine on interpatient pharmacokinetic variability of atorvastatin in obese subjects.	SLCO1B1 ABCB1	4.61e-05	3	137	2	23361102
Pubmed	Human α-defensin (DEFA) gene expression helps to characterise benign and malignant salivary gland tumours.	DEFA1 DEFA3	4.61e-05	3	137	2	23050799
Pubmed	Tenascin during gut development: appearance in the mesenchyme, shift in molecular forms, and dependence on epithelial-mesenchymal interactions.	FN1 TNC	4.61e-05	3	137	2	2461951
Pubmed	Determination of the disulfide array in the human defensin HNP-2. A covalently cyclized peptide.	DEFA1 DEFA3	4.61e-05	3	137	2	2917986
Pubmed	Expression of tenascin in developing and adult mouse lymphoid organs.	FN1 TNC	4.61e-05	3	137	2	7687262
Pubmed	Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells.	DEFA1 DEFA3	4.61e-05	3	137	2	10914484
Pubmed	ZGRF1 promotes end resection of DNA homologous recombination via forming complex with BRCA1/EXO1.	ZGRF1 BRCA1	4.61e-05	3	137	2	34552057
Pubmed	Effect of SLCO1B1 polymorphism on induction of CYP3A4 by rifampicin.	SLCO1B1 ABCB1	4.61e-05	3	137	2	16847425
Pubmed	Polymorphisms in drug transporter genes (ABCB1, SLCO1B1 and ABCC2) and hepatitis induced by antituberculosis drugs.	SLCO1B1 ABCB1	4.61e-05	3	137	2	22178260
Pubmed	Human neutrophil alpha-defensin 4 inhibits HIV-1 infection in vitro.	DEFA1 DEFA3	4.61e-05	3	137	2	15620707
Pubmed	Human alpha-defensins inhibit Clostridium difficile toxin B.	DEFA1 DEFA3	4.61e-05	3	137	2	18435932
Pubmed	The structure of neutrophil defensin genes.	DEFA1 DEFA3	4.61e-05	3	137	2	8325384
Pubmed	Inhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residues.	CPT1A CPT1B	4.61e-05	3	137	2	11023836
Pubmed	Inheritance of unequal numbers of the genes encoding the human neutrophil defensins HP-1 and HP-3.	DEFA1 DEFA3	4.61e-05	3	137	2	8530462
Pubmed	Salivary antimicrobial peptides (LL-37 and alpha-defensins HNP1-3), antimicrobial and IgA responses to prolonged exercise.	DEFA1 DEFA3	4.61e-05	3	137	2	19263072
Pubmed	Intraarticular release and accumulation of defensins and bactericidal/permeability-increasing protein in patients with rheumatoid arthritis.	DEFA1 DEFA3	4.61e-05	3	137	2	12913926
Pubmed	Defensins. Natural peptide antibiotics of human neutrophils.	DEFA1 DEFA3	4.61e-05	3	137	2	2997278
Pubmed	Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival.	FN1 TNC	4.61e-05	3	137	2	28652369
Pubmed	Increased levels of human neutrophil peptides 1, 2, and 3 in peritoneal fluid of patients with endometriosis: association with neutrophils, T cells and IL-8.	DEFA1 DEFA3	4.61e-05	3	137	2	21831449
Pubmed	Alpha-defensins 1-3 release by dendritic cells is reduced by estrogen.	DEFA1 DEFA3	4.61e-05	3	137	2	21861873
Pubmed	PPBP and DEFA1/DEFA3 genes in hyperlipidaemia as feasible synergistic inflammatory biomarkers for coronary heart disease.	DEFA1 DEFA3	4.61e-05	3	137	2	28420383
Pubmed	Contribution of alpha- and beta-defensins to lung function decline and infection in smokers: an association study.	DEFA1 DEFA3	4.61e-05	3	137	2	16700921
Pubmed	Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors.	ABCB1 BRCA1	4.61e-05	3	137	2	23103855
Pubmed	Primary structures of three human neutrophil defensins.	DEFA1 DEFA3	4.61e-05	3	137	2	4056036
Pubmed	Simvastatin does not influence the intestinal P-glycoprotein and MPR2, and the disposition of talinolol after chronic medication in healthy subjects genotyped for the ABCB1, ABCC2 and SLCO1B1 polymorphisms.	SLCO1B1 ABCB1	4.61e-05	3	137	2	16542205
Pubmed	Evaluation of gingival crevicular fluid adrenomedullin and human neutrophil peptide 1-3 levels of patients with different periodontal diseases.	DEFA1 DEFA3	4.61e-05	3	137	2	20151808
Interaction	CRISP2 interactions	PLXNA3 LAMB2 BMP1 RNF123 ADAMTS7 TLL2 TMEM132A	7.23e-09	40	133	7	int:CRISP2
Interaction	C1QB interactions	PLXNA3 FN1 CHRNA5 DEFA1 BMP1 ADAMTS7 TMEM132A	2.95e-06	94	133	7	int:C1QB
Interaction	BAG2 interactions	VWA5B2 ASXL1 GAPVD1 DCAF8 FN1 EXPH5 EDC4 SP110 AAR2 TUBGCP6 NCOR1 PHC3 RPAP1 KDM6A NLRP5	1.56e-05	622	133	15	int:BAG2
Interaction	TRGV3 interactions	LAMB2 CHRNA5 BMP1 ADAMTS7 TMEM132A	3.10e-05	55	133	5	int:TRGV3
Cytoband	8p21.3	NUDT18 INTS10 BMP1	2.03e-04	38	137	3	8p21.3
GeneFamily	Fibronectin type III domain containing	BOC PRTG IL31RA FN1 TNC MYOM3 OBSCN CMYA5 TEK PTPRD CSF3R USH2A SDK1	1.52e-12	160	92	13	555
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	BOC PRTG MYOM3 OBSCN PTPRD SDK1 ALPK2	1.81e-05	161	92	7	593
GeneFamily	Bone morphogenetic proteins\|Astacins	BMP1 TLL2	3.79e-04	6	92	2	894
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	CC2D1A RAB11FIP1 C2CD3	8.06e-04	36	92	3	823
GeneFamily	Defensins, alpha	DEFA1 DEFA3	1.64e-03	12	92	2	502
GeneFamily	Cholinergic receptors nicotinic subunits	CHRNA5 CHRNE	2.93e-03	16	92	2	173
GeneFamily	Cadherin related	DCHS2 DCHS1	3.31e-03	17	92	2	24
Coexpression	LEIN_CEREBELLUM_MARKERS	TNC EXPH5 CMYA5 KANK2 PKP3 CA7	5.69e-06	85	137	6	MM720
Coexpression	LEIN_CEREBELLUM_MARKERS	TNC EXPH5 CMYA5 KANK2 PKP3 CA7	5.69e-06	85	137	6	M1723
Coexpression	LEE_BMP2_TARGETS_UP	WIPI1 DCAF8 TEK KANK2 CLDN23 ABCB1 GGT5 TMEM132C BMP1 PTPRD GLB1 QPRT DCHS1 CPXM1 ZFYVE26	1.49e-05	780	137	15	M2324
Coexpression	LEE_BMP2_TARGETS_UP	WIPI1 DCAF8 TEK KANK2 CLDN23 ABCB1 GGT5 TMEM132C BMP1 PTPRD GLB1 QPRT DCHS1 CPXM1 ZFYVE26	2.15e-05	805	137	15	MM1067
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MYOM3 LGSN PTPRD NGEF KIAA1755 PNPLA3 ALPK2 SLC27A2	6.60e-09	186	137	9	a417e1e21313a7e05951038cdef5ac672a9f727c
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MYOM3 LGSN PTPRD NGEF PNPLA3 ALPK2 SLC27A2	9.85e-08	182	137	8	e1e58176f533092b6b974ca1ce8b02192a6e193d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MYOM3 LGSN PTPRD NGEF KIAA1755 ALPK2 SLC27A2	9.85e-08	182	137	8	4a9c13932e7163fd37a3dcc4c6ca3bbea5372459
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MYOM3 LGSN PTPRD NGEF PNPLA3 ALPK2 SLC27A2	9.85e-08	182	137	8	57bb5a2da976464ba7c4460106bd9f692008ebd9
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 DCHS2 MYOM3 LGSN KIAA1755 USH2A ALPK2 SLC27A2	1.03e-07	183	137	8	d73cac83cde82665f110baad7cf28db75f9ffe52
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	FN1 TNC SLCO3A1 AKAP12 TMEM132C PTPRD CPXM1 SDK1	2.03e-07	200	137	8	9b0916d8d07ac2bf1739f7be5296bf77ffee6094
ToppCell	Hematolymphoid-Endothelial-NOSTRIN\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	ATP9A TEK RBM20 ABCB1 GGT5 TMEM132C RANBP17 KIAA1755	2.03e-07	200	137	8	032df80aa5c40991e1c1e80f9d8da106e6aeaee2
ToppCell	Hematolymphoid-Endothelial-NOSTRIN---\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	ATP9A TEK RBM20 ABCB1 GGT5 TMEM132C RANBP17 KIAA1755	2.03e-07	200	137	8	68fce28690246895fd33354b30960ebcc31aa4cc
ToppCell	Hematolymphoid-Endothelial-NOSTRIN-\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	ATP9A TEK RBM20 ABCB1 GGT5 TMEM132C RANBP17 KIAA1755	2.03e-07	200	137	8	376b19ab5a7cd2c85f726d8ba41337d4525863e5
ToppCell	Hematolymphoid-Endothelial-NOSTRIN--\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	ATP9A TEK RBM20 ABCB1 GGT5 TMEM132C RANBP17 KIAA1755	2.03e-07	200	137	8	7fa54370221ed61bac0e09e6bcf1f3dff202a846
ToppCell	Hematolymphoid-Endothelial-NOSTRIN----L2-6\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	ATP9A TEK RBM20 ABCB1 GGT5 TMEM132C RANBP17 KIAA1755	2.03e-07	200	137	8	878bbbe32e3602723aa14ef32877ab2453b8c6e5
ToppCell	Hematolymphoid-Endothelial\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	ATP9A TEK RBM20 ABCB1 GGT5 TMEM132C RANBP17 KIAA1755	2.03e-07	200	137	8	7136936d05ab344a560cf159684c881063b5430d
ToppCell	LPS_only-Epithelial_airway-Ciliated_cells-Ciliated\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TCTE1 RSPH4A MAP1A CLDN23 ANKEF1 CCDC78 USH2A	5.09e-07	154	137	7	9ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCell	LPS_only-Epithelial_airway-Ciliated_cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TCTE1 RSPH4A MAP1A CLDN23 ANKEF1 CCDC78 USH2A	5.09e-07	154	137	7	58072ce422d09f2de602580325eaac6c4ec6c136
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Alveolar_fibro\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	DCHS2 FN1 AKAP12 CHRNE TMEM132C PTPRD DCHS1	8.43e-07	166	137	7	65dafed953b01a9830b54309af75c7a561e88336
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MYOM3 LGSN NGEF KIAA1755 ALPK2 SLC27A2	1.40e-06	179	137	7	d1ef7e1cb00336118e387b47f4f8120f53584391
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MYOM3 AKAP12 PTPRD NGEF SDK1 ALPK2	1.80e-06	186	137	7	f28d72b47624b69a580b4429e2be560a26898591
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MYOM3 PTPRD NGEF PNPLA3 ALPK2 SLC27A2	1.87e-06	187	137	7	1b82920588f9e26ef1db244d452736d75fcfd342
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MYOM3 PTPRD NGEF PNPLA3 ALPK2 SLC27A2	1.87e-06	187	137	7	c1e4c0345f9bfa0538730bad5ff3fa5240168b25
ToppCell	LA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	PRUNE2 MYOM3 OBSCN TACC2 CMYA5 RBM20 ALPK2	1.93e-06	188	137	7	6d249fe92d51a19da19ec14bb2262d394255d577
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MYOM3 PTPRD NGEF PNPLA3 ALPK2 SLC27A2	1.93e-06	188	137	7	f3edcefeef2ce19086032d98b243c02a6d542b38
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MYOM3 PTPRD NGEF PNPLA3 ALPK2 SLC27A2	1.93e-06	188	137	7	0792432cd4c564dea1102241ea9884f7ced7658c
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MYOM3 ABCB1 PTPRD SDK1 ALPK2 SLC27A2	2.00e-06	189	137	7	28b502611829e4a24caff2562545c7db97686099
ToppCell	COVID-19-kidney-PCT-S2\|kidney / Disease (COVID-19 only), tissue and cell type	PRUNE2 MYOM3 AKAP12 PTPRD SDK1 ALPK2 SLC27A2	2.00e-06	189	137	7	0be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MYOM3 AKAP12 PTPRD NGEF SDK1 ALPK2	2.08e-06	190	137	7	989d4eefd22d66ecb857836f8fdbcf41e3047f84
ToppCell	5'-Adult-LargeIntestine-Epithelial-Tuft-related\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRUNE2 AOC1 CC2D1A RAB11FIP1 CLDN23 TINCR CA7	2.73e-06	198	137	7	a631be84e29c277216d89ec6265bd43e87c1dc86
ToppCell	LPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	TNC CMYA5 KANK2 AKAP12 TMEM132C QPRT PLCB1	2.91e-06	200	137	7	09537dc25f8b8b4654a7c183827ee1522a41a4e0
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast\|LPS_only / Treatment groups by lineage, cell group, cell type	PRUNE2 MAP1A TNC LAMB2 TACC2 KANK2 QPRT	2.91e-06	200	137	7	593bf6a7c557437db9a9249a5058a46014179ef6
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 TNC AKAP12 ABCB1 PTPRD ALPK2 SLC27A2	2.91e-06	200	137	7	105564ee05bd11685b5747ee32d5350cf3c2e2e1
ToppCell	LPS_only-Mesenchymal_myocytic-Myofibroblastic\|LPS_only / Treatment groups by lineage, cell group, cell type	PRUNE2 MAP1A TNC TACC2 KANK2 TMEM132C QPRT	2.91e-06	200	137	7	02cae2c296a13ad4cbb53bca7a86d64629d67d66
ToppCell	LPS-IL1RA+antiTNF-Unknown-Endothelial-Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRUNE2 DCHS2 CC2D1A ABCB1 TMEM132A DCHS1	8.28e-06	154	137	6	16fdafb5c64d2db321554f87129a962d113f1668
ToppCell	Adult-Immune-enucleated_erythrocyte\|Adult / Lineage, Cell type, age group and donor	ATG9B EDC4 CHRNA5 CHRNE TLL2 ALPK2	8.60e-06	155	137	6	e2d07ee4348d2c1d3552a8d0337ea42777c31f9c
ToppCell	3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PRUNE2 DCAF8 RSPH4A CPT1B CCDC78 SLC27A2	9.94e-06	159	137	6	5543f5aec6352a7c5923e55daf3ed40ff5cc0f0c
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5\|TCGA-Ovary / Sample_Type by Project: Shred V9	OBSCN USP19 PCNX2 RNF123 CPLANE1 IMPG2	1.27e-05	166	137	6	32d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAP1A IL25 SLCO3A1 CMYA5 RP1L1 PNPLA3	1.45e-05	170	137	6	17bd7fd25a2657cb536ad47e294332920f759e95
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNPO2L OBSCN CMYA5 CPT1B RBM20 ALPK2	1.55e-05	172	137	6	ee8ce9e8c9a6d3ee2be113f77743958005f4b3f0
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNPO2L OBSCN CMYA5 CPT1B RBM20 ALPK2	1.55e-05	172	137	6	bd468a7ea6ec832dcf6a816a1e0c03fa0f176dad
ToppCell	facs-Large_Intestine-Distal-24m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAP1A IL25 SLCO3A1 TEK ADAMTS7 PNPLA3	1.61e-05	173	137	6	f0eb48c1283bdde313bb75f6ffc0d2626922d24b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 LGSN KIAA1755 PNPLA3 ALPK2 SLC27A2	1.83e-05	177	137	6	2f81b26be89cc2fd8eafadaf7eae3c6ad6521462
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MYOM3 PTPRD NGEF ALPK2 SLC27A2	1.95e-05	179	137	6	58ae5a97fe2a14e1c6fdeb886397eb06fdaf0428
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MYOM3 PTPRD PNPLA3 ALPK2 SLC27A2	2.07e-05	181	137	6	9542c19edc9bd2cba68c01c2a8407705398e3011
ToppCell	Endothelial-B-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	PRUNE2 PCDHB14 PGAP4 TEK DCHS1 KEL	2.07e-05	181	137	6	4fe0215d08f03d4e24749d70fce01b7aa22906fd
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MYOM3 PTPRD PNPLA3 ALPK2 SLC27A2	2.07e-05	181	137	6	8f04f8cac5d705dc5f6cf6f4516d6e45b0aa4ae5
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BOC PRUNE2 SLCO3A1 ABCB1 PTPRD ALPK2	2.14e-05	182	137	6	5e1b316599436740f1b30875f0ebd33c3edfb2b6
ToppCell	COVID-19-Heart-CM_3\|Heart / Disease (COVID-19 only), tissue and cell type	MYOM3 OBSCN TACC2 CMYA5 RBM20 ALPK2	2.14e-05	182	137	6	287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BOC FN1 TNC CMYA5 PLCB1 KIAA1755	2.14e-05	182	137	6	3dfa9187e9d2bab1d199079d29209c4648220ada
ToppCell	NS-moderate-d_16-33-Lymphoid-NK\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PRTG FN1 TNC AKAP12 GGT5 DCHS1	2.14e-05	182	137	6	fb503f8ecd013f1f2161a5841572b57cfcddb6fa
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MYOM3 LGSN KIAA1755 ALPK2 SLC27A2	2.20e-05	183	137	6	85446581999cd66b171c4f69b7eb8b0bbbaa8617
ToppCell	droplet-Kidney-nan-21m-Mesenchymal-podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRUNE2 TNC MAP3K6 AKAP12 BMP1 SDK1	2.20e-05	183	137	6	ad7421623e4c0c5ba02eec56e9bdae43ebb88d90
ToppCell	3'_v3-bone_marrow-Hematopoietic_progenitors-Progenitor_MEMP\|bone_marrow / Manually curated celltypes from each tissue	PRTG PGAP4 TEK CPXM1 KEL SLC27A2	2.27e-05	184	137	6	b81a2a95944cee8fec13d63dc0d95496e67aa937
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 LGSN KIAA1755 PNPLA3 ALPK2 SLC27A2	2.27e-05	184	137	6	9434731f651820b05335085582960f08fbf895de
ToppCell	COVID-19-Heart-CM_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MYOM3 OBSCN TACC2 CMYA5 RBM20 ALPK2	2.34e-05	185	137	6	549eeb521c3985bff396ea0f202db21822efa51f
ToppCell	facs-Heart-LA-24m-Mesenchymal-ventricular_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHF24 SYNPO2L CMYA5 CPT1B RBM20 ALPK2	2.42e-05	186	137	6	337f768cc43db2db96ba6495b076006b1a5b0331
ToppCell	facs-Heart-LA-24m-Mesenchymal-ventricular_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHF24 SYNPO2L CMYA5 CPT1B RBM20 ALPK2	2.42e-05	186	137	6	e378c82ef6d6cb24751515aa499a01372b3e7ccf
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MYOM3 PTPRD NGEF ALPK2 SLC27A2	2.42e-05	186	137	6	8287146f0ba415ea04475588117d4668ae00f75c
ToppCell	COVID-19-Fibroblasts-Airway_smooth_muscle\|COVID-19 / group, cell type (main and fine annotations)	PRUNE2 FN1 TNC RBM20 AKAP12 SDK1	2.49e-05	187	137	6	464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MYOM3 PTPRD NGEF ALPK2 SLC27A2	2.49e-05	187	137	6	71eb26ebf60cb0848e5bf1cd01edccda621aecd8
ToppCell	facs-Heart-Unknown-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNPO2L OBSCN CMYA5 CPT1B RBM20 ALPK2	2.49e-05	187	137	6	0ffb988e0da2c7205c3515eca8e9851739bff5c5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 AKAP12 ABCB1 PTPRD SDK1 ALPK2	2.49e-05	187	137	6	9d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCell	facs-Heart-Unknown\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNPO2L OBSCN CMYA5 CPT1B RBM20 ALPK2	2.49e-05	187	137	6	362e56426a568423a81e8a30e3ecf99b76135843
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|World / Chamber and Cluster_Paper	MYOM3 OBSCN TACC2 CMYA5 RBM20 ALPK2	2.49e-05	187	137	6	78cdcf8bc141d3b155c3c8af908431fc419c4d08
ToppCell	facs-Heart-Unknown-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNPO2L OBSCN CMYA5 CPT1B RBM20 ALPK2	2.49e-05	187	137	6	c004567767b89f3d89f5c7b28d952f3445957e1e
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BOC PHF24 KANK2 TMEM132C PTPRD CPXM1	2.57e-05	188	137	6	b382d18fb09fb2869f3c151efa71540a7f5ed229
ToppCell	normal-na-Hematopoietic-progenitor_cell\|normal / PBMC cell types (v2) per disease, treatment status, and sex	PGAP4 ZSCAN1 PTPRD CPXM1 KEL SLC27A2	2.57e-05	188	137	6	013162466a3334b6967c0cb670c8577d809b1396
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNPO2L OBSCN CMYA5 CPT1B RBM20 ALPK2	2.57e-05	188	137	6	90dc0e15798d0b984518ad58c7e416e30aff687a
ToppCell	normal-na-Hematopoietic-progenitor_cell-female\|normal / PBMC cell types (v2) per disease, treatment status, and sex	PGAP4 ZSCAN1 PTPRD CPXM1 KEL SLC27A2	2.57e-05	188	137	6	be25371e6459504b5f0c9ece3a0fe8f80c7824ca
ToppCell	E16.5-samps-Mesenchymal\|E16.5-samps / Age Group, Lineage, Cell class and subclass	BOC WIPI1 FN1 TNC AKAP12 PTPRD	2.57e-05	188	137	6	3f0f662be684e3a4c6652e636cc135a39a1d2790
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNPO2L OBSCN CMYA5 CPT1B RBM20 ALPK2	2.57e-05	188	137	6	f63dfd076ced81013918363282ae25cbbd8948ae
ToppCell	facs-Heart-LA/RA-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNPO2L OBSCN CMYA5 CPT1B RBM20 ALPK2	2.57e-05	188	137	6	0554d542149cef654ff1e5e32dfbffd8990b52bd
ToppCell	RV-04._Ventricular_Cardiomyocyte_I\|RV / Chamber and Cluster_Paper	MYOM3 OBSCN TACC2 CMYA5 RBM20 ALPK2	2.64e-05	189	137	6	9c1debd65c13d63fd4f3158917d621b44b714c26
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MYOM3 PTPRD NGEF ALPK2 SLC27A2	2.64e-05	189	137	6	204ab61ae606b2d9be0cb6bf6a83a011740693a8
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	MYOM3 OBSCN TACC2 CMYA5 RBM20 ALPK2	2.64e-05	189	137	6	5e80c47f63980904c4c1ff02c201b67b456a0974
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 AKAP12 ABCB1 PTPRD SDK1 ALPK2	2.64e-05	189	137	6	3b48b0d220cc24d5170713d61fa91f5bb6c21841
ToppCell	facs-Heart-LA/RA-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNPO2L OBSCN CMYA5 CPT1B RBM20 ALPK2	2.64e-05	189	137	6	a08b2d0fa35ffa510050ecffdc68e1b79bbe1632
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 MYOM3 PTPRD NGEF ALPK2 SLC27A2	2.64e-05	189	137	6	13fd07cc408a9486f61a7b2c3a132c52d14b438d
ToppCell	systemic_lupus_erythematosus-managed-Hematopoietic-progenitor_cell\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	PGAP4 ZSCAN1 PTPRD CPXM1 KEL SLC27A2	2.64e-05	189	137	6	6687a93ac8540ece5fd762f6f77c1f25f159195b
ToppCell	(1)_Osterolineage_cells-(10)_OLC-1\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	TNC GGT5 NHSL1 BMP1 PTPRD CPXM1	2.64e-05	189	137	6	46c5b975fb9d33017f2d9b7770d45a8bdf95baa2
ToppCell	3'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BOC PRUNE2 MAP1A TNC KANK2 AKAP12	2.64e-05	189	137	6	63449d9f1e78ff2bc8786eb88a0d177fe30c7f4d
ToppCell	facs-Heart-LA/RA\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYNPO2L OBSCN CMYA5 CPT1B RBM20 ALPK2	2.64e-05	189	137	6	efa913d9c16fc32166b484d92b6449e8a0c59e03
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BOC PRUNE2 TNC KANK2 TMEM132C QPRT	2.64e-05	189	137	6	45e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TNC SLCO3A1 TMEM132C PTPRD KIAA1755 SDK1	2.72e-05	190	137	6	45df8fee00f8949937863159d7aa042e72748d9b
ToppCell	RV-06._Ventricular_Cardiomyocyte_II\|RV / Chamber and Cluster_Paper	MYOM3 OBSCN TACC2 CMYA5 RBM20 ALPK2	2.72e-05	190	137	6	fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BOC PLXNA3 TNC AKAP12 KIAA1755 CPXM1	2.80e-05	191	137	6	4b50fdd310701251e64e16cd2d07ce03dbfd3e3e
ToppCell	LA-03._Atrial_Cardiomyocyte\|LA / Chamber and Cluster_Paper	MYOM3 OBSCN TACC2 CMYA5 RBM20 ALPK2	2.80e-05	191	137	6	5d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCell	E18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BOC PLXNA3 TNC AKAP12 KIAA1755 CPXM1	2.80e-05	191	137	6	75d2197076a9dfc868e8baf95bd4c5e44f438e3e
ToppCell	facs-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FN1 SLCO3A1 TEK AKAP12 NHSL1 BMP1	2.89e-05	192	137	6	30cefa0990ba1f379f350bfbf994a78db145075e
ToppCell	LV-04._Ventricular_Cardiomyocyte_I\|LV / Chamber and Cluster_Paper	MYOM3 OBSCN TACC2 CMYA5 RBM20 ALPK2	2.89e-05	192	137	6	ad19e2c1d36a0566c9b12ced10db78f4781c8ea6
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FN1 TNC SLCO3A1 TMEM132C PTPRD SDK1	2.89e-05	192	137	6	3d0cb19f037f604253d7d728689aeaa94251e92b
ToppCell	COVID-19-Heart-CM_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	MYOM3 OBSCN TACC2 CMYA5 RBM20 ALPK2	2.97e-05	193	137	6	dd5378a1ef8eb0eda9a3aae62f3c2f3a1402bda0
ToppCell	LA\|World / Chamber and Cluster_Paper	PRUNE2 FN1 PCNX2 PLCB1 PNPLA3 SDK1	2.97e-05	193	137	6	d4bf89437216baf489ea0239136dcedf3b6714af
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-stromal_related-FDC\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRUNE2 FN1 GGT5 CSF3R KEL ALPK2	3.06e-05	194	137	6	f9fbb043411546d8c9e0321a64165d411f44aeb7
ToppCell	RA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	PRUNE2 OBSCN TACC2 CMYA5 RBM20 ALPK2	3.06e-05	194	137	6	89812fb164065041357bb37a3c2d87028ec3de4e
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TNC SLCO3A1 TMEM132C PTPRD KIAA1755 SDK1	3.06e-05	194	137	6	89b706af2b25991fc2707eb24f49ba6ff3ae01f7
ToppCell	RA-03._Atrial_Cardiomyocyte\|RA / Chamber and Cluster_Paper	MYOM3 OBSCN TACC2 CMYA5 RBM20 ALPK2	3.06e-05	194	137	6	c3535f7cc0076653c72db582047cff053c322397
ToppCell	COVID-19-Heart-CM_1\|Heart / Disease (COVID-19 only), tissue and cell type	MYOM3 OBSCN TACC2 CMYA5 RBM20 ALPK2	3.15e-05	195	137	6	f1ef50331eda8f1239dba6ea970df4eaccf032f1
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	MYOM3 OBSCN TACC2 CMYA5 RBM20 ALPK2	3.15e-05	195	137	6	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	LPS-IL1RA-Myeloid-Myeloid_granulocytic-Neutrophils\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TNC SLCO3A1 CSF3R SDK1 CA7	3.23e-05	118	137	5	6053e19d040fb394f9c270361af07b0c5a4d47db
ToppCell	LPS-IL1RA-Myeloid-Myeloid_granulocytic\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TNC SLCO3A1 CSF3R SDK1 CA7	3.23e-05	118	137	5	811e8521129914eef46785a4227c1860e77d9096
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Pericyte-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FN1 LAMB2 KANK2 RBM20 GGT5 BMP1	3.33e-05	197	137	6	2872a78b1be61aa1d50bc9a49294a21e922dc033
ToppCell	5'-Adult-LargeIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRUNE2 AOC1 RAB11FIP1 CLDN23 TINCR CA7	3.43e-05	198	137	6	efdbac7a3a02bff4ca48841772e0c136556c2b9b
Drug	NSC123895	BOC ABCB1 KEL	2.08e-07	3	136	3	CID000413765
Drug	Trichlorfon [52-68-6]; Down 200; 15.6uM; HL60; HT_HG-U133A	TRMO CPT1A CPT1B USP19 DHX30 PCNX2 PLCB1 GM2A KDM6A	3.07e-06	198	136	9	1839_DN
Drug	3-bromopropionate	DEFA1 DEFA3 GLB1	7.17e-06	7	136	3	CID000011553
Drug	Proadifen hydrochloride [62-68-0]; Up 200; 10.2uM; MCF7; HT_HG-U133A	NUDT18 WIPI1 DCAF8 USP19 BMP1 PLCB1 GM2A NCR2	2.15e-05	193	136	8	3446_UP
Drug	Cyclizine hydrochloride [303-25-3]; Down 200; 13.2uM; MCF7; HT_HG-U133A	PLXNA3 DCAF8 EXPH5 FANCA BMP1 PHC3 GM2A SNX11	2.23e-05	194	136	8	2880_DN
Drug	Azapropazone [13539-59-8]; Down 200; 13.4uM; PC3; HT_HG-U133A	RCBTB2 CC2D1A SP110 PHC3 RPAP1 TMEM132A KDM6A PRRC2A	2.40e-05	196	136	8	7277_DN
Drug	Glipizide [29094-61-9]; Up 200; 9uM; MCF7; HT_HG-U133A	NUDT18 SLCO3A1 AKAP12 NCOR1 C2CD3 KDM6A PRRC2A IMPG2	2.40e-05	196	136	8	1508_UP
Drug	6-aminohexanol	CPT1A LGSN GLB1	2.43e-05	10	136	3	CID000019960
Drug	Hydroxyzine dihydrochloride [2192-20-3]; Down 200; 9uM; PC3; HG-U133A	ASXL1 CEP85 NOL6 LAMB2 CC2D1A RAB11FIP1 MAP3K6 GM2A	2.49e-05	197	136	8	1941_DN
Drug	2-methoxyethoxy)acetic acid	DEFA1 DEFA3	3.54e-05	2	136	2	CID000027642
Drug	1,2,5,6-tetramethylnaphthalene	DEFA1 DEFA3	3.54e-05	2	136	2	CID006427081
Drug	1,4,5-trimethylnaphthalene	DEFA1 DEFA3	3.54e-05	2	136	2	CID000016478
Drug	p-sulfobenzyl alcohol	DEFA1 DEFA3	3.54e-05	2	136	2	CID000441138
Disease	Malignant neoplasm of breast	BOC KDM3A UTS2R FN1 OBSCN TACC2 ZMIZ1 CPT1A TEK SLCO1B1 SP110 MAP3K6 AKAP12 ABCB1 BMP1 NCOR1 PTPRD BRCA1 ANKEF1 PLCB1 ZFYVE26 PRRC2A	3.83e-09	1074	135	22	C0006142
Disease	MYELODYSPLASTIC SYNDROME	ASXL1 FANCA BRCA1 CSF3R PLCB1	1.43e-05	67	135	5	C3463824
Disease	esophagus squamous cell carcinoma (is_implicated_in)	CHRNA5 FANCA BRCA1 KDM6A	5.40e-05	45	135	4	DOID:3748 (is_implicated_in)
Disease	obesity (implicated_via_orthology)	KDM3A DCHS2 DCHS1 PLCB1 PNPLA3 SDK1 TMEM18	6.22e-05	215	135	7	DOID:9970 (implicated_via_orthology)
Disease	myocardial infarction (biomarker_via_orthology)	UTS2R FN1 TNC TEK PLCB1 KDM6A	9.77e-05	160	135	6	DOID:5844 (biomarker_via_orthology)
Disease	X-11372 measurement	SLCO1B1 SLC27A2	1.24e-04	4	135	2	EFO_0800694
Disease	X-03056--N-[3- 2-Oxopyrrolidin-1-yl propyl]acetamide measurement	AOC1 CHRNE	1.24e-04	4	135	2	EFO_0021186
Disease	X-24020 measurement	AOC1 TUBGCP6	2.06e-04	5	135	2	EFO_0022128
Disease	chronic myelomonocytic leukemia (is_implicated_in)	ASXL1 CSF3R	2.06e-04	5	135	2	DOID:0080188 (is_implicated_in)
Disease	alkaline phosphatase measurement	WIPI1 EMC1 AOC1 MAP1A PGAP4 ZMIZ1 LARP1B CPT1A SLCO1B1 CLDN23 CHRNE RP1L1 SMS ALPK2	2.39e-04	1015	135	14	EFO_0004533
Disease	cervical cancer (is_implicated_in)	KDM3A FANCA BRCA1	3.47e-04	30	135	3	DOID:4362 (is_implicated_in)
Disease	myelodysplastic syndrome (is_implicated_in)	ASXL1 CSF3R PLCB1	3.47e-04	30	135	3	DOID:0050908 (is_implicated_in)
Disease	X-16935 measurement	SLCO1B1 SLC27A2	4.30e-04	7	135	2	EFO_0800763
Disease	asparaginase hypersensitivity	SLCO3A1 ZMIZ1 SLCO1B1 ERMARD	4.38e-04	77	135	4	EFO_0004881
Disease	monocyte percentage of leukocytes	ZMIZ1 SLCO1B1 CHRNE FANCA GGT5 DEFA3 BRCA1 CSF3R PLCB1 KIAA1755 PNPLA3	5.57e-04	731	135	11	EFO_0007989
Disease	Fanconi anemia (is_implicated_in)	FANCA BRCA1	9.13e-04	10	135	2	DOID:13636 (is_implicated_in)
Disease	smoking behavior	GAPVD1 NOL6 CHRNA5 RANBP17 PRRC2A SDK1 TMEM18	1.01e-03	341	135	7	EFO_0004318
Disease	alpha fetoprotein measurement	WIPI1 SLCO1B1 NCOR1 PNPLA3	1.17e-03	100	135	4	EFO_0010583
Disease	N-acetylputrescine measurement	AOC1 TUBGCP6	1.33e-03	12	135	2	EFO_0800127
Disease	arachidonoylcarnitine (C20:4) measurement	CPT1A SLCO1B1	1.33e-03	12	135	2	EFO_0800544
Disease	papillary thyroid carcinoma	TRMO PCNX2	1.33e-03	12	135	2	EFO_0000641
Disease	Dental enamel hypoplasia	ZMIZ1 PTPRD	1.33e-03	12	135	2	EFO_1001304
Disease	Colorectal Carcinoma	BOC FN1 OBSCN ZMIZ1 AKAP12 ABCB1 PTPRD RPAP1 DCHS1 KDM6A	1.50e-03	702	135	10	C0009402
Disease	non-alcoholic fatty liver disease	ZMIZ1 PTPRD PLCB1 PNPLA3 ALPK2	1.53e-03	182	135	5	EFO_0003095
Disease	Dupuytren Contracture	DCHS2 TACC2 ATP9A SDK1	1.55e-03	108	135	4	EFO_0004229
Disease	dihomo-linolenoylcarnitine (C20:3n3 or 6) measurement	CPT1A SLCO1B1	1.57e-03	13	135	2	EFO_0800547
Disease	PR interval	IL25 SUN1 SYNPO2L OBSCN LAMB2 ZMIZ1 CHRNE KIAA1755	2.05e-03	495	135	8	EFO_0004462
Disease	ecosanoids measurement	SLCO1B1 PNPLA3 SLC27A2	2.07e-03	55	135	3	EFO_0020044
Disease	nasopharynx carcinoma (is_implicated_in)	CHRNA5 BRCA1	2.10e-03	15	135	2	DOID:9261 (is_implicated_in)
Disease	ferritin measurement	FN1 STRADB PTPRD RP1L1	2.22e-03	119	135	4	EFO_0004459
Disease	urate measurement, bone density	CCDC71L ATG9B AKAP12 FANCA RANBP17 PTPRD PLCB1 KIAA1755 USH2A	2.24e-03	619	135	9	EFO_0003923, EFO_0004531
Disease	decreased susceptibility to hepatitis C infection	PTPRD ATOH1	2.39e-03	16	135	2	EFO_0010101
Disease	velopharyngeal dysfunction	DCHS2 CLDN23 PTPRD LILRA4	2.43e-03	122	135	4	EFO_0009336
Disease	Mammary Carcinoma, Human	FN1 CPT1A SLCO1B1 AKAP12 ABCB1 NCOR1 PTPRD BRCA1	2.94e-03	525	135	8	C4704874
Disease	Mammary Neoplasms, Human	FN1 CPT1A SLCO1B1 AKAP12 ABCB1 NCOR1 PTPRD BRCA1	2.94e-03	525	135	8	C1257931
Disease	Mammary Neoplasms	FN1 CPT1A SLCO1B1 AKAP12 ABCB1 NCOR1 PTPRD BRCA1	3.01e-03	527	135	8	C1458155
Disease	CCL5 measurement	CCDC71L AOC1 F12	3.18e-03	64	135	3	EFO_0005117
Disease	QT interval	AOC1 NOL6 SYNPO2L LAMB2 ZMIZ1 KANK2 KIAA1755 ATOH1	3.26e-03	534	135	8	EFO_0004682
Disease	Seizures	PNKP ZMIZ1 CHRNA5 GLB1 GM2A	3.35e-03	218	135	5	C0036572
Disease	gamma-aminoisobutyric acid measurement	AOC1 TACC2	3.38e-03	19	135	2	EFO_0010482
Disease	ovulation	FANCA PRRC2A	3.38e-03	19	135	2	GO_0030728
Disease	Breast Carcinoma	FN1 CPT1A SLCO1B1 AKAP12 ABCB1 NCOR1 PTPRD BRCA1	3.41e-03	538	135	8	C0678222
Disease	Microcephaly	PNKP PUS3 ZMIZ1	3.62e-03	67	135	3	C0025958
Disease	C-reactive protein measurement	DCHS2 MAP1A ZMIZ1 ATP9A KANK2 CLDN23 FANCA RANBP17 NCOR1 RP1L1 TDRD10 SNX11 TMEM18	3.64e-03	1206	135	13	EFO_0004458
Disease	myelodysplastic syndrome (is_marker_for)	CSF3R PLCB1	3.74e-03	20	135	2	DOID:0050908 (is_marker_for)
Disease	Adenocarcinoma of prostate	FANCA BRCA1	3.74e-03	20	135	2	C0007112
Disease	Benign Neoplasm	ABCB1 BRCA1 KDM6A	3.78e-03	68	135	3	C0086692
Disease	Neoplasms	ABCB1 BRCA1 KDM6A	3.78e-03	68	135	3	C0027651
Disease	lung non-small cell carcinoma (is_implicated_in)	CHRNA5 ABCB1 BRCA1 KDM6A	3.88e-03	139	135	4	DOID:3908 (is_implicated_in)
Disease	gastric ulcer (biomarker_via_orthology)	IL25 TEK	4.12e-03	21	135	2	DOID:10808 (biomarker_via_orthology)
Disease	p-tau measurement	SUN1 PTPRD CSF3R	4.44e-03	72	135	3	EFO_0004763
Disease	pulse pressure measurement, alcohol consumption measurement	CCDC71L TACC2	4.52e-03	22	135	2	EFO_0005763, EFO_0007878

Protein segments in the cluster

Peptide	Gene	Start	Entry
TWLVDPTLSRDTSPL	nan	126	Q8NBF4
LEASASEIWPPRQLT	ALPK2	1241	Q86TB3
RAATIIEERSPSWIS	AKAP12	901	Q02952
PSWISASVTEPLEQV	AKAP12	911	Q02952
WSTLREEVDLSPAPE	AAR2	91	Q9Y312
EVLSEPWRLSTSQTP	CPT1A	676	P50416
TPTPDDAVFRWLSTV	CPXM1	521	Q96SM3
VDITFIPRRIWSPEA	ANKEF1	716	Q9NU02
IPRRIWSPEATTAEL	ANKEF1	721	Q9NU02
PSLASRDTVIVWPRD	AOC1	706	P19801
PVESSWIAPELRLQS	DHX30	366	Q7L2E3
LPEPIVSTDSRLWVE	BMP1	401	P13497
DPLDSLTSLWTVPSR	ASXL1	951	Q8IXJ9
EVPLSSRLLSTPAWD	ADAMTS7	1366	Q9UKP4
ETLRVPSELVWLPEI	CHRNE	96	Q04844
ATPAVTWRLLSVEPD	RCBTB2	361	O95199
QIPTTWRTIFLEPET	RANBP17	246	Q9H2T7
SWEPEDVFSELSIPL	RBM20	1136	Q5T481
VWPTAPDITRETCST	EDC4	826	Q6P2E9
PDQPVVWREISIITS	INTS10	71	Q9NVR2
DPETEEPLWASRTVN	LEMD3	231	Q9Y2U8
EALDESIPPVSFWRI	ABCB1	686	P08183
TIPQPWELRVSEDAL	DCHS1	2276	Q96JQ0
AEDPEWSLAIVPLLT	TCTE1	66	Q5JU00
VSSEWSAPSDPLDIL	LILRA4	301	P59901
WPEVSPEDTQSLSLS	MAP1A	1186	P78559
VTDLPWTSVSSPVER	NCR2	241	O95944
EPETLLSVEERGPSW	NUDT18	101	Q6ZVK8
PDVDSEPTTLSWESV	IL31RA	361	Q8NI17
VPWTKITSPEFVDDR	KIAA1755	176	Q5JYT7
TTRVLEQTLSPLWDE	FER1L4	796	A9Z1Z3
EAPWPSAQSEIRTIS	GAPVD1	1371	Q14C86
EAWSLPIPAELTSRQ	KDM6A	421	O15550
SAPNTITVLELEWAP	GLB1	611	P16278
LEEWVSSETSALPRP	DCAF8L2	171	P0C7V8
LLEPETQDIPSSWTF	MAP3K6	556	O95382
DLEEPWLPRSRSQST	NHSL1	731	Q5SYE7
SREPWESVSRLTPDT	PCNX2	486	A6NKB5
QDPTVTRLEPTWSII	PLXNA3	1021	P51805
PWDESILDTLSPRLA	PNPLA3	311	Q9NST1
VEPPALDTAWVEATR	GPS1	121	Q13098
LEDWVSSETSALPRP	DCAF8	136	Q5TAQ9
SVPETELTDQAWLPA	NOL6	121	Q9H6R4
ELTPRAWERIISPVE	EXPH5	1151	Q8NEV8
AWERIISPVESDSSV	EXPH5	1156	Q8NEV8
VVERLVTPGETPSWT	LAMB2	581	P55268
WSDVPVPRISVIFSL	TUBGCP6	616	Q96RT7
NVISTPVRPEDLWSA	MOCOS	166	Q96EN8
ISREWPDSQAPVTEI	NLRP5	336	P59047
PPVTLAALVDSWLRE	QPRT	11	Q15274
PPISESLSIENTLWA	ATP9A	246	O75110
ATPRPWLVITIITVD	PGAP4	96	Q9BRR3
SDLLPVAQTEPSIWT	PHC3	906	Q8NDX5
EVVPVDATPEWLSLI	DCHS2	3061	Q6V1P9
TSRSPTDILISWLPI	PRTG	526	Q2VWP7
ERSSVTLEVELTRPW	OBSCN	2001	Q5VST9
VPEDRPLGSWIATIS	PCDHB14	251	Q9Y5E9
SENPRDTEDVPWITL	BRCA1	361	P38398
IRVPSDSVWTPDIVL	CHRNA5	121	P30532
SPEISERIVQWPAIT	KDM3A	101	Q9Y4C1
PSITPRLWQDAELAT	BOC	411	Q9BWV1
EGEPATVTISTPRLW	C2CD3	1401	Q4AC94
PEVVVSLAWDESLAP	DEFA1	41	P59665
PEVVVSLAWDESLAP	DEFA3	41	P59666
WSQVIPEEAVLLPST	CPLANE1	161	Q9H799
EREETVVSPWTIPSE	CPLANE1	3111	Q9H799
VNETDSTVLVRWTPP	FN1	1006	P02751
QPLSEEDVASLSWRP	FANCA	881	O15360
ATIRWRPTTPEATET	CMYA5	3821	Q8N3K9
TEWQTPVISEPFRSR	CEP85	31	Q6P2H3
PELSLLDSTDPRAWL	ATOH1	51	Q92858
TTTERWLVIDPVPAA	CC2D1A	801	Q6P1N0
PWPALATTLETVATE	GGT5	216	P36269
TAVWATSLEAEVPPD	CCDC78	36	A2IDD5
PEELSSVPWAEVQSR	ATG9B	321	Q674R7
WSPSLELRTTERAPT	CSF3R	321	Q99062
PEDPVALETRSVGTW	KANK2	256	Q63ZY3
TLEEIWRAATPTLTT	CCDC71L	176	Q8N9Z2
TTPPLSESVTWIVLR	CA7	201	P43166
DTSEELLRWSTVPVP	IL25	46	Q9H293
SIRVWALLPFPEELT	ERMARD	446	Q5T6L9
TTELSWELTIPPEVQ	EMC1	691	Q8N766
SETSLRLRWVPLPDS	SDK1	1186	Q7Z5N4
RRSSVSTIQVEWPEP	CLDN23	201	Q96B33
EVLSEPWRLSTSQIP	CPT1B	676	Q92523
STSLPDLDSEPWIEV	LARP1B	361	Q659C4
PELSTFRVLPWADRT	LGSN	151	Q5TDP6
SILLSWTPPRSDTIA	PTPRD	531	P23468
LVSLESTLSIPPWEA	F12	11	P00748
SEDLEIQNIPPWTTR	RSPH4A	596	Q5TD94
EFVVPDLELPSWLTT	GM2A	151	P17900
VLAPRAATTLDEPIW	SYNPO2L	906	Q9H987
VESLWSLTQTLEAPP	USH2A	3951	O75445
ISTSTPIESWPLVDR	RAB11FIP1	606	Q6WKZ4
PISTSPEEDSTWEFL	SMS	281	P52788
VWAPVVDSEVPSLES	SNX11	206	Q9Y5W9
DIRILAWAPVEPSFS	PUS3	171	Q9BZE2
SEPETRFTVRQLEPW	PRUNE2	1161	Q8WUY3
PSLSVPWLQDRIEDS	RPP38	201	P78345
IDTSNLDITPDDPRW	SLCO3A1	246	Q9UIG8
WAPLLPLRIELTDTT	TMEM132A	491	Q24JP5
VWVPRLPLQIEVSDT	TMEM132C	521	Q8N3T6
VSTEPIPESWRSEVT	SLC27A2	201	O14975
RSLDSDDFWTIPPLT	TDRD10	296	Q5VZ19
ATSPAEETVVWSPEV	MRGBP	21	Q9NV56
EPISTEPVETSRWTE	NCOR1	616	O75376
GWTTPIPLIEDSEEI	SLITRK3	26	O94933
EEWPALADSPTTLTE	NGEF	141	Q8N5V2
EAIPVSRDWELLPSA	PRRC2A	1791	P48634
DETFWRELPSVPSLD	SHOC1	1351	Q5VXU9
PLTLRWEETRTPESQ	PNKP	101	Q96T60
ILPESERVWTRTSSL	IMPG2	776	Q9BZV3
EWQSRDTPILLEAPT	SP110	111	Q9HB58
LLPTEQESRFVDWPT	PHF24	361	Q9UPV7
DLSTIRITPTDSRWV	SLCO1B1	241	Q9Y6L6
PWIRELILGSETPSS	ACD	11	Q96AP0
WPEATEVSPSRTIRA	PKP3	231	Q9Y446
PNWTVRSDSELEIPV	WFDC3	216	Q8IUB2
PAWVTEAPVATLEVR	TRMO	326	Q9BU70
TPTPELLLDWRQSAE	USP19	111	O94966
SSPEAVVREWLDNIP	RP1L1	951	Q8IWN7
LVPEIFLDWTRPTSE	RNF123	1091	Q5XPI4
AAPALPEESEWLETT	ZSCAN1	166	Q8NBB4
TEVQSETALLTWRPP	TNC	1896	P24821
PEPLVSTDSRLWVEF	TLL2	431	Q9Y6L7
LTVPEANSEPWTLDT	TACC2	1641	O95359
SEDLTAWTLSDILPP	TEK	626	Q02763
ETIVREFLPTSWSPV	RPAP1	591	Q9BWH6
PIWSVDSDEPNLTSV	UBE2Q2L	86	H0YL09
WDDDSTIVTPIILRT	PLCB1	31	Q9NQ66
RLTPAIPALWEAEAS	TINCR	91	A0A2R8Y7D0
WASPTEPSSLEDLVA	UTS2R	36	Q9UKP6
WFVPDTVEALLTPRE	VWA5B2	531	Q8N398
TEIERSPLLEWLPTL	ZGRF1	1901	Q86YA3
LVDEPTLSWSRPSTR	STRADB	31	Q9C0K7
DAVTRRPPVLDESWI	SUN1	126	O94901
RPPVLDESWIREQTT	SUN1	131	O94901
LEQVTNSRPEEPSTW	WIPI1	261	Q5MNZ9
DFWISTALVEPTAPL	ZFYVE26	946	Q68DK2
VWTEIAPIRPESSDS	TBX21	476	Q9UL17
PVSIPAVLTQTDWTE	TMEM18	11	Q96B42
FEEVTIDPTCSWRPV	ZMIZ1	811	Q9ULJ6
GTLWSQESTPEERLP	KEL	21	P23276
SEVRATSLVLQWEPP	MYOM3	811	Q5VTT5