Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity	NANOGP8 NANOG	2.22e-05	4	39	2	GO:0001010
GeneOntologyMolecularFunction	transcription factor binding	CCNT1 NANOGP8 NFIA PRDM16 LEF1 NANOG MEIS2	5.65e-04	753	39	7	GO:0008134
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	NANOGP8 NFIA PRDM16 LEF1 NANOG MEIS2	7.03e-04	560	39	6	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	NANOGP8 NFIA PRDM16 LEF1 NANOG MEIS2	7.43e-04	566	39	6	GO:0001216
GeneOntologyMolecularFunction	lysine-acetylated histone binding	NANOGP8 NANOG	1.56e-03	30	39	2	GO:0070577
GeneOntologyMolecularFunction	acetylation-dependent protein binding	NANOGP8 NANOG	1.67e-03	31	39	2	GO:0140033
GeneOntologyBiologicalProcess	negative regulation of endodermal cell fate specification	NANOGP8 NANOG	1.98e-05	4	38	2	GO:0042664
GeneOntologyBiologicalProcess	regulation of endodermal cell fate specification	NANOGP8 NANOG	3.29e-05	5	38	2	GO:0042663
GeneOntologyBiologicalProcess	positive regulation of cell population proliferation	S1PR2 NANOGP8 BCL7A LEF1 AVPR2 PTPRZ1 DISC1 NANOG MEIS2 ZNF335	4.21e-05	1190	38	10	GO:0008284
GeneOntologyBiologicalProcess	negative regulation of endodermal cell differentiation	NANOGP8 NANOG	4.93e-05	6	38	2	GO:1903225
GeneOntologyBiologicalProcess	neural precursor cell proliferation	NFIA LEF1 PTPRZ1 DISC1 ZNF335	6.53e-05	233	38	5	GO:0061351
GeneOntologyBiologicalProcess	negative regulation of cell fate specification	NANOGP8 NANOG	9.19e-05	8	38	2	GO:0009996
GeneOntologyBiologicalProcess	regulation of endodermal cell differentiation	NANOGP8 NANOG	1.47e-04	10	38	2	GO:1903224
GeneOntologyBiologicalProcess	endodermal cell fate specification	NANOGP8 NANOG	1.80e-04	11	38	2	GO:0001714
GeneOntologyBiologicalProcess	head development	ZFAND5 SSTR3 LEF1 AVPR2 DISC1 MEIS2 ZNF335 AMIGO1	2.24e-04	919	38	8	GO:0060322
GeneOntologyBiologicalProcess	cell dedifferentiation	NANOGP8 NANOG	3.42e-04	15	38	2	GO:0043697
GeneOntologyBiologicalProcess	dedifferentiation	NANOGP8 NANOG	3.42e-04	15	38	2	GO:0043696
GeneOntologyBiologicalProcess	negative regulation of cell fate commitment	NANOGP8 NANOG	4.42e-04	17	38	2	GO:0010454
GeneOntologyBiologicalProcess	positive regulation by host of viral transcription	CCNT1 LEF1	4.42e-04	17	38	2	GO:0043923
GeneOntologyBiologicalProcess	BMP signaling pathway	NANOGP8 NFIA LEF1 NANOG	4.62e-04	197	38	4	GO:0030509
GeneOntologyBiologicalProcess	mesoderm formation	NANOGP8 LEF1 NANOG	4.62e-04	82	38	3	GO:0001707
GeneOntologyBiologicalProcess	endodermal cell fate commitment	NANOGP8 NANOG	4.96e-04	18	38	2	GO:0001711
GeneOntologyBiologicalProcess	regulation of stem cell division	NANOGP8 NANOG	4.96e-04	18	38	2	GO:2000035
GeneOntologyBiologicalProcess	mesoderm morphogenesis	NANOGP8 LEF1 NANOG	5.31e-04	86	38	3	GO:0048332
GeneOntologyBiologicalProcess	response to BMP	NANOGP8 NFIA LEF1 NANOG	6.42e-04	215	38	4	GO:0071772
GeneOntologyBiologicalProcess	cellular response to BMP stimulus	NANOGP8 NFIA LEF1 NANOG	6.42e-04	215	38	4	GO:0071773
GeneOntologyBiologicalProcess	regulation of cell development	S1PR2 PRDM16 LEF1 PTPRZ1 DISC1 MEIS2 ZNF335 AMIGO1	7.23e-04	1095	38	8	GO:0060284
GeneOntologyBiologicalProcess	mesodermal cell fate commitment	NANOGP8 NANOG	8.16e-04	23	38	2	GO:0001710
GeneOntologyBiologicalProcess	positive regulation of cell development	S1PR2 LEF1 PTPRZ1 DISC1 ZNF335 AMIGO1	8.33e-04	614	38	6	GO:0010720
GeneOntologyBiologicalProcess	brain development	SSTR3 LEF1 AVPR2 DISC1 MEIS2 ZNF335 AMIGO1	8.64e-04	859	38	7	GO:0007420
GeneOntologyBiologicalProcess	stem cell population maintenance	NANOGP8 BCL7A PRDM16 NANOG	9.23e-04	237	38	4	GO:0019827
GeneOntologyBiologicalProcess	neuroblast proliferation	LEF1 DISC1 ZNF335	9.24e-04	104	38	3	GO:0007405
GeneOntologyBiologicalProcess	maintenance of cell number	NANOGP8 BCL7A PRDM16 NANOG	9.97e-04	242	38	4	GO:0098727
GeneOntologyBiologicalProcess	response to growth factor	DOCK3 NANOGP8 NFIA PRDM16 LEF1 NANOG MEIS2	1.02e-03	883	38	7	GO:0070848
GeneOntologyBiologicalProcess	somatic stem cell population maintenance	NANOGP8 PRDM16 NANOG	1.03e-03	108	38	3	GO:0035019
GeneOntologyBiologicalProcess	tongue development	PRDM16 LEF1	1.13e-03	27	38	2	GO:0043586
GeneOntologyBiologicalProcess	neuron projection fasciculation	PTPRZ1 AMIGO1	1.21e-03	28	38	2	GO:0106030
GeneOntologyBiologicalProcess	axonal fasciculation	PTPRZ1 AMIGO1	1.21e-03	28	38	2	GO:0007413
GeneOntologyBiologicalProcess	transforming growth factor beta receptor superfamily signaling pathway	NANOGP8 NFIA PRDM16 LEF1 NANOG	1.28e-03	445	38	5	GO:0141091
GeneOntologyBiologicalProcess	central nervous system development	SSTR3 LEF1 AVPR2 PTPRZ1 DISC1 MEIS2 ZNF335 AMIGO1	1.29e-03	1197	38	8	GO:0007417
GeneOntologyBiologicalProcess	regulation of cell fate specification	NANOGP8 NANOG	1.30e-03	29	38	2	GO:0042659
GeneOntologyBiologicalProcess	negative regulation of developmental process	NANOGP8 BCL7A PRDM16 LEF1 PTPRZ1 NANOG MEIS2 MBNL3	1.46e-03	1220	38	8	GO:0051093
GeneOntologyBiologicalProcess	cell fate specification	NANOGP8 NFIA NANOG	1.50e-03	123	38	3	GO:0001708
GeneOntologyBiologicalProcess	formation of primary germ layer	NANOGP8 LEF1 NANOG	1.53e-03	124	38	3	GO:0001704
GeneOntologyBiologicalProcess	regulation of granulocyte differentiation	PRDM16 LEF1	1.68e-03	33	38	2	GO:0030852
GeneOntologyBiologicalProcess	negative regulation of stem cell differentiation	NANOGP8 NANOG	1.68e-03	33	38	2	GO:2000737
GeneOntologyBiologicalProcess	cell surface receptor protein serine/threonine kinase signaling pathway	NANOGP8 NFIA PRDM16 LEF1 NANOG	1.81e-03	482	38	5	GO:0007178
GeneOntologyBiologicalProcess	mesodermal cell differentiation	NANOGP8 NANOG	1.89e-03	35	38	2	GO:0048333
GeneOntologyBiologicalProcess	forebrain development	SSTR3 LEF1 AVPR2 DISC1 ZNF335	1.93e-03	489	38	5	GO:0030900
GeneOntologyBiologicalProcess	regulation of neural precursor cell proliferation	PTPRZ1 DISC1 ZNF335	1.96e-03	135	38	3	GO:2000177
Domain	SEA	MUC16 MUC12	9.56e-04	22	39	2	PF01390
Domain	SEA	MUC16 MUC12	1.05e-03	23	39	2	PS50024
Domain	SEA_dom	MUC16 MUC12	1.05e-03	23	39	2	IPR000082
Domain	cNMP_binding	CNBD1 RAPGEF6	2.29e-03	34	39	2	PF00027
Domain	cNMP-bd_dom	CNBD1 RAPGEF6	2.42e-03	35	39	2	IPR000595
Domain	CNMP_BINDING_3	CNBD1 RAPGEF6	2.42e-03	35	39	2	PS50042
Domain	cNMP-bd-like	CNBD1 RAPGEF6	2.85e-03	38	39	2	IPR018490
Pathway	REACTOME_DEFECTIVE_GALNT3_CAUSES_HFTC	MUC16 MUC5B MUC12	3.45e-06	16	27	3	M27410
Pathway	REACTOME_DEFECTIVE_C1GALT1C1_CAUSES_TNPS	MUC16 MUC5B MUC12	4.19e-06	17	27	3	M27412
Pathway	REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS	MUC16 MUC5B MUC12	1.08e-05	23	27	3	M556
Pathway	REACTOME_DECTIN_2_FAMILY	MUC16 MUC5B MUC12	1.58e-05	26	27	3	M27483
Pathway	REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS	MUC16 MUC5B MUC12	2.20e-04	62	27	3	M546
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	MUC16 MUC5B MUC12	2.89e-04	68	27	3	M27303
Pathway	REACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION	LEF1 NANOG	4.72e-04	17	27	2	M45017
Pathway	REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS	MUC16 MUC5B	7.25e-04	21	27	2	MM15706
Pathway	WP_WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY	NANOGP8 LEF1 NANOG	9.21e-04	101	27	3	MM15829
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	MUC16 MUC5B MUC12	1.21e-03	111	27	3	M27416
Pubmed	Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.	MUC16 MUC5B MUC12	1.14e-06	18	40	3	18834073
Pubmed	Nanog1 in NTERA-2 and recombinant NanogP8 from somatic cancer cells adopt multiple protein conformations and migrate at multiple M.W species.	NANOGP8 NANOG	1.29e-06	2	40	2	24598770
Pubmed	Differential expression of nanog1 and nanogp8 in colon cancer cells.	NANOGP8 NANOG	1.29e-06	2	40	2	22079639
Pubmed	Expression of NANOG and NANOGP8 in a variety of undifferentiated and differentiated human cells.	NANOGP8 NANOG	1.29e-06	2	40	2	21136380
Pubmed	Functional evidence that the self-renewal gene NANOG regulates human tumor development.	NANOGP8 NANOG	1.29e-06	2	40	2	19415763
Pubmed	Arrest of WNT/β-catenin signaling enables the transition from pluripotent to differentiated germ cells in mouse ovaries.	NANOGP8 LEF1 NANOG	3.60e-06	26	40	3	34301885
Pubmed	Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells.	NANOGP8 NANOG	3.87e-06	3	40	2	25825768
Pubmed	Epithelial cell senescence induces pulmonary fibrosis through Nanog-mediated fibroblast activation.	NANOGP8 NANOG	3.87e-06	3	40	2	31891567
Pubmed	Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.	NANOGP8 NANOG	3.87e-06	3	40	2	19447925
Pubmed	The pluripotency factor NANOG controls primitive hematopoiesis and directly regulates Tal1.	NANOGP8 NANOG	3.87e-06	3	40	2	30814124
Pubmed	Identification of two distinct transactivation domains in the pluripotency sustaining factor nanog.	NANOGP8 NANOG	3.87e-06	3	40	2	14728807
Pubmed	Isolation and characterization of the murine Nanog gene promoter.	NANOGP8 NANOG	3.87e-06	3	40	2	15916719
Pubmed	The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells.	NANOGP8 NANOG	3.87e-06	3	40	2	30846691
Pubmed	Generation of germline-competent induced pluripotent stem cells.	NANOGP8 NANOG	3.87e-06	3	40	2	17554338
Pubmed	Multiple phases in regulation of Nanog expression during pre-implantation development.	NANOGP8 NANOG	3.87e-06	3	40	2	26660234
Pubmed	Nanog retrotransposed genes with functionally conserved open reading frames.	NANOGP8 NANOG	3.87e-06	3	40	2	16845474
Pubmed	Nanog overcomes reprogramming barriers and induces pluripotency in minimal conditions.	NANOGP8 NANOG	3.87e-06	3	40	2	21194951
Pubmed	Identification and regulation of a stage-specific stem cell niche enriched by Nanog-positive spermatogonial stem cells in the mouse testis.	NANOGP8 NANOG	3.87e-06	3	40	2	22388986
Pubmed	NANOG changes in mouse kidneys with age.	NANOGP8 NANOG	3.87e-06	3	40	2	16313224
Pubmed	Crystal structure and DNA binding of the homeodomain of the stem cell transcription factor Nanog.	NANOGP8 NANOG	3.87e-06	3	40	2	18177668
Pubmed	Nanog promotes transfer of pluripotency after cell fusion.	NANOGP8 NANOG	3.87e-06	3	40	2	16791199
Pubmed	Expression of Nanog gene promotes NIH3T3 cell proliferation.	NANOGP8 NANOG	3.87e-06	3	40	2	16259959
Pubmed	Effect of Nanog overexpression on the metastatic potential of a mouse melanoma cell line B16-BL6.	NANOGP8 NANOG	3.87e-06	3	40	2	33665763
Pubmed	A novel NK-type homeobox gene, ENK (early embryo specific NK), preferentially expressed in embryonic stem cells.	NANOGP8 NANOG	3.87e-06	3	40	2	12609610
Pubmed	Heparan sulfate regulates self-renewal and pluripotency of embryonic stem cells.	NANOGP8 NANOG	3.87e-06	3	40	2	18024963
Pubmed	The pluripotency factor Nanog regulates pericentromeric heterochromatin organization in mouse embryonic stem cells.	NANOGP8 NANOG	3.87e-06	3	40	2	27125671
Pubmed	Cutting edge: Hypoxia-induced Nanog favors the intratumoral infiltration of regulatory T cells and macrophages via direct regulation of TGF-β1.	NANOGP8 NANOG	3.87e-06	3	40	2	24227785
Pubmed	Reprogramming capacity of Nanog is functionally conserved in vertebrates and resides in a unique homeodomain.	NANOGP8 NANOG	3.87e-06	3	40	2	22028025
Pubmed	Context-Dependent Functions of NANOG Phosphorylation in Pluripotency and Reprogramming.	NANOGP8 NANOG	3.87e-06	3	40	2	28457890
Pubmed	Requirement of Nanog dimerization for stem cell self-renewal and pluripotency.	NANOGP8 NANOG	3.87e-06	3	40	2	18436640
Pubmed	Stochastic promoter activation affects Nanog expression variability in mouse embryonic stem cells.	NANOGP8 NANOG	3.87e-06	3	40	2	25410303
Pubmed	Nanog co-regulated by Nodal/Smad2 and Oct4 is required for pluripotency in developing mouse epiblast.	NANOGP8 NANOG	3.87e-06	3	40	2	24929238
Pubmed	Nanog and transcriptional networks in embryonic stem cell pluripotency.	NANOGP8 NANOG	3.87e-06	3	40	2	17211451
Pubmed	The pluripotency factor nanog promotes breast cancer tumorigenesis and metastasis.	NANOGP8 NANOG	3.87e-06	3	40	2	23770853
Pubmed	The stem cell pluripotency factor NANOG activates transcription with two unusually potent subdomains at its C terminus.	NANOGP8 NANOG	3.87e-06	3	40	2	15502159
Pubmed	Genome editing demonstrates that the -5 kb Nanog enhancer regulates Nanog expression by modulating RNAPII initiation and/or recruitment.	NANOGP8 NANOG	3.87e-06	3	40	2	33334884
Pubmed	NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation.	NANOGP8 NANOG	3.87e-06	3	40	2	21499299
Pubmed	Nanog variability and pluripotency regulation of embryonic stem cells--insights from a mathematical model analysis.	NANOGP8 NANOG	3.87e-06	3	40	2	20574542
Pubmed	lincRNAs act in the circuitry controlling pluripotency and differentiation.	NANOGP8 NANOG	3.87e-06	3	40	2	21874018
Pubmed	Cell signalling regulates dynamics of Nanog distribution in embryonic stem cell populations.	NANOGP8 NANOG	3.87e-06	3	40	2	23054952
Pubmed	Phosphorylation of NANOG by casein kinase I regulates embryonic stem cell self-renewal.	NANOGP8 NANOG	3.87e-06	3	40	2	33107035
Pubmed	Nanog-independent reprogramming to iPSCs with canonical factors.	NANOGP8 NANOG	3.87e-06	3	40	2	24527385
Pubmed	Aromatic residues in the C-terminal domain 2 are required for Nanog to mediate LIF-independent self-renewal of mouse embryonic stem cells.	NANOGP8 NANOG	3.87e-06	3	40	2	18086680
Pubmed	Forced expression of Nanog in hematopoietic stem cells results in a gammadeltaT-cell disorder.	NANOGP8 NANOG	3.87e-06	3	40	2	17360937
Pubmed	H3K9 tri-methylation at Nanog times differentiation commitment and enables the acquisition of primitive endoderm fate.	NANOGP8 NANOG	3.87e-06	3	40	2	35976266
Pubmed	DUSP28 links regulation of Mucin 5B and Mucin 16 to migration and survival of AsPC-1 human pancreatic cancer cells.	MUC16 MUC5B	3.87e-06	3	40	2	27230679
Pubmed	Nanog dynamics in single embryonic stem cells.	NANOGP8 NANOG	3.87e-06	3	40	2	26760119
Pubmed	Regulation of Nanog expression by phosphoinositide 3-kinase-dependent signaling in murine embryonic stem cells.	NANOGP8 NANOG	3.87e-06	3	40	2	17204467
Pubmed	CrxOS maintains the self-renewal capacity of murine embryonic stem cells.	NANOGP8 NANOG	3.87e-06	3	40	2	19800316
Pubmed	Nanog is dispensable for the generation of induced pluripotent stem cells.	NANOGP8 NANOG	3.87e-06	3	40	2	24461999
Pubmed	Chromatin decondensation and nuclear softening accompany Nanog downregulation in embryonic stem cells.	NANOGP8 NANOG	3.87e-06	3	40	2	23200040
Pubmed	Selenium Augments microRNA Directed Reprogramming of Fibroblasts to Cardiomyocytes via Nanog.	NANOGP8 NANOG	3.87e-06	3	40	2	26975336
Pubmed	Nanog suppresses cell migration by downregulating thymosin β4 and Rnd3.	NANOGP8 NANOG	3.87e-06	3	40	2	23329853
Pubmed	Locating and Characterizing a Transgene Integration Site by Nanopore Sequencing.	NANOGP8 NANOG	3.87e-06	3	40	2	30837263
Pubmed	NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers.	NANOGP8 NANOG	3.87e-06	3	40	2	26751055
Pubmed	Nanog induces hyperplasia without initiating tumors.	NANOGP8 NANOG	3.87e-06	3	40	2	25173648
Pubmed	Distinct Contributions of Tryptophan Residues within the Dimerization Domain to Nanog Function.	NANOGP8 NANOG	3.87e-06	3	40	2	27939294
Pubmed	Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells.	NANOGP8 NANOG	3.87e-06	3	40	2	17352742
Pubmed	OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells.	NANOGP8 NANOG	3.87e-06	3	40	2	23178592
Pubmed	Stochastic NANOG fluctuations allow mouse embryonic stem cells to explore pluripotency.	NANOGP8 NANOG	3.87e-06	3	40	2	25005472
Pubmed	Cell-permeant recombinant Nanog protein promotes pluripotency by inhibiting endodermal specification.	NANOGP8 NANOG	3.87e-06	3	40	2	24681518
Pubmed	Roles of the Nanog protein in murine F9 embryonal carcinoma cells and their endoderm-differentiated counterparts.	NANOGP8 NANOG	3.87e-06	3	40	2	16773043
Pubmed	Genome-wide chromatin interactions of the Nanog locus in pluripotency, differentiation, and reprogramming.	NANOGP8 NANOG	3.87e-06	3	40	2	23665121
Pubmed	Ectopic overexpression of Nanog induces tumorigenesis in non-tumorous fibroblasts.	NANOGP8 NANOG	3.87e-06	3	40	2	26733157
Pubmed	Transient Activation of Mitoflashes Modulates Nanog at the Early Phase of Somatic Cell Reprogramming.	NANOGP8 NANOG	3.87e-06	3	40	2	26549484
Pubmed	mNanog possesses dorsal mesoderm-inducing ability by modulating both BMP and Activin/nodal signaling in Xenopus ectodermal cells.	NANOGP8 NANOG	3.87e-06	3	40	2	23071603
Pubmed	Overexpression of NANOG in human ES cells enables feeder-free growth while inducing primitive ectoderm features.	NANOGP8 NANOG	3.87e-06	3	40	2	16501172
Pubmed	Regulated fluctuations in nanog expression mediate cell fate decisions in embryonic stem cells.	NANOGP8 NANOG	3.87e-06	3	40	2	19582141
Pubmed	Identification of genes regulated by nanog which is involved in ES cells pluripotency and early differentiation.	NANOGP8 NANOG	3.87e-06	3	40	2	18442017
Pubmed	NANOG induction of fetal liver kinase-1 (FLK1) transcription regulates endothelial cell proliferation and angiogenesis.	NANOGP8 NANOG	3.87e-06	3	40	2	21119109
Pubmed	Pluripotency factor NANOG promotes germ cell maintenance in vitro without triggering dedifferentiation of spermatogonial stem cells.	NANOGP8 NANOG	3.87e-06	3	40	2	32145514
Pubmed	Nanog is the gateway to the pluripotent ground state.	NANOGP8 NANOG	3.87e-06	3	40	2	19703398
Pubmed	Nanog safeguards pluripotency and mediates germline development.	NANOGP8 NANOG	3.87e-06	3	40	2	18097409
Pubmed	Nanog Fluctuations in Embryonic Stem Cells Highlight the Problem of Measurement in Cell Biology.	NANOGP8 NANOG	3.87e-06	3	40	2	28636920
Pubmed	Heterogeneities in Nanog Expression Drive Stable Commitment to Pluripotency in the Mouse Blastocyst.	NANOGP8 NANOG	3.87e-06	3	40	2	25753417
Pubmed	A distinct expression pattern in mammalian testes indicates a conserved role for NANOG in spermatogenesis.	NANOGP8 NANOG	3.87e-06	3	40	2	20539761
Pubmed	Differential Expression of MUC12, MUC16, and MUC20 in Patients with Active and Remission Ulcerative Colitis.	MUC16 MUC12	3.87e-06	3	40	2	26770020
Pubmed	Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes.	NANOGP8 NANOG	3.87e-06	3	40	2	18584034
Pubmed	Alternative splicing produces Nanog protein variants with different capacities for self-renewal and pluripotency in embryonic stem cells.	NANOGP8 NANOG	3.87e-06	3	40	2	21969378
Pubmed	The phosphoinositide-3-kinase/Akt pathway mediates the transient increase in Nanog expression during differentiation of F9 cells.	NANOGP8 NANOG	3.87e-06	3	40	2	20661723
Pubmed	NANOG restores the impaired myogenic differentiation potential of skeletal myoblasts after multiple population doublings.	NANOGP8 NANOG	3.87e-06	3	40	2	29245050
Pubmed	Cancer vaccination drives Nanog-dependent evolution of tumor cells toward an immune-resistant and stem-like phenotype.	NANOGP8 NANOG	3.87e-06	3	40	2	22337995
Pubmed	Mapping dynamic histone acetylation patterns to gene expression in nanog-depleted murine embryonic stem cells.	NANOGP8 NANOG	3.87e-06	3	40	2	21187909
Pubmed	Functional analysis of two Sp1/Sp3 binding sites in murine Nanog gene promoter.	NANOGP8 NANOG	3.87e-06	3	40	2	16541131
Pubmed	Role of Nanog in the maintenance of marrow stromal stem cells during post natal bone regeneration.	NANOGP8 NANOG	3.87e-06	3	40	2	22142851
Pubmed	The pluripotency rheostat Nanog functions as a dimer.	NANOGP8 NANOG	3.87e-06	3	40	2	18290762
Pubmed	NANOG amplifies STAT3 activation and they synergistically induce the naive pluripotent program.	NANOGP8 NANOG	3.87e-06	3	40	2	24462001
Pubmed	Reprogramming of mouse fibroblasts into induced pluripotent stem cells with Nanog.	NANOGP8 NANOG	3.87e-06	3	40	2	23333380
Pubmed	A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal.	NANOGP8 NANOG	3.87e-06	3	40	2	16790525
Pubmed	Primitive endoderm differentiates via a three-step mechanism involving Nanog and RTK signaling.	NANOGP8 NANOG	3.87e-06	3	40	2	22172669
Pubmed	Nanog-dependent feedback loops regulate murine embryonic stem cell heterogeneity.	NANOGP8 NANOG	3.87e-06	3	40	2	23103910
Pubmed	Aggregation of embryonic stem cells induces Nanog repression and primitive endoderm differentiation.	NANOGP8 NANOG	3.87e-06	3	40	2	15494369
Pubmed	XPO5 promotes primary miRNA processing independently of RanGTP.	NANOGP8 LEF1 NANOG	5.04e-06	29	40	3	32296071
Pubmed	The histone acetyltransferase Myst2 regulates Nanog expression, and is involved in maintaining pluripotency and self-renewal of embryonic stem cells.	NANOGP8 NANOG	7.73e-06	4	40	2	25743411
Pubmed	CtBP-interacting BTB zinc finger protein (CIBZ) promotes proliferation and G1/S transition in embryonic stem cells via Nanog.	NANOGP8 NANOG	7.73e-06	4	40	2	22315219
Pubmed	GATA-1 directly regulates Nanog in mouse embryonic stem cells.	NANOGP8 NANOG	7.73e-06	4	40	2	26296469
Pubmed	Expansion of undifferentiated murine embryonic stem cells as aggregates in suspension culture bioreactors.	NANOGP8 NANOG	7.73e-06	4	40	2	17518637
Pubmed	Cyclic mechanical strain maintains Nanog expression through PI3K/Akt signaling in mouse embryonic stem cells.	NANOGP8 NANOG	7.73e-06	4	40	2	22683858
Pubmed	USP21 deubiquitylates Nanog to regulate protein stability and stem cell pluripotency.	NANOGP8 NANOG	7.73e-06	4	40	2	29263902
Pubmed	Nanog positively regulates Zfp57 expression in mouse embryonic stem cells.	NANOGP8 NANOG	7.73e-06	4	40	2	25445595
Cytoband	15q14	NANOGP8 MEIS2	8.48e-04	49	40	2	15q14
Cytoband	Ensembl 112 genes in cytogenetic band chr15q14	NANOGP8 MEIS2	1.31e-03	61	40	2	chr15q14
GeneFamily	CD molecules\|Mucins	MUC16 MUC5B MUC12	3.06e-06	21	25	3	648
GeneFamily	NKL subclass homeoboxes and pseudogenes	NANOGP8 NANOG	3.84e-03	67	25	2	519
GeneFamily	PDZ domain containing	RAPGEF6 RIMS2	1.86e-02	152	25	2	1220
ToppCell	Tracheal\|World / Cell types per location group and 10X technology with lineage, and cell group designations	MUC16 MUC5B NFIA PTPRZ1 DTNB MEIS2 TPD52L1	5.08e-10	200	40	7	682960e28542a3d6c119047cd0131941932cfdea
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	RAPGEF6 NFIA LEF1 RBMS1 GYPC	7.83e-07	192	40	5	1c0ce299cee9ab5cdea256f3e8c1e5598577a8b6
ToppCell	NS-moderate-d_0-4\|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SPAG17 NFIA PTPRZ1 MEIS2 CDHR4	8.03e-07	193	40	5	ea345d34440b25f65358a53dc72831998d1c3620
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MUC16 MUC5B PTPRZ1 DTNB TPD52L1	9.57e-07	200	40	5	85c0f038bcfb42669dca2b80273b0f8a1421405e
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-Tnaive/CM_CD4\|Lung / Manually curated celltypes from each tissue	RAPGEF6 SPAG17 LEF1 CDHR4	1.34e-05	162	40	4	91cc14aec8d580cf97a1929bc1acb00fcbcdb57a
ToppCell	LPS-antiTNF-Epithelial_airway\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MUC5B SPAG17 PRDM16 PTPRZ1	1.47e-05	166	40	4	eb942ed68677e55c46cb039046f45686d4062d7c
ToppCell	Ciliated_cells-A-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	MUC16 MUC5B SPAG17 CDHR4	2.02e-05	180	40	4	d9be152773fe9f2160edad9246fa03c03afeafd6
ToppCell	RV\|World / Chamber and Cluster_Paper	NAV1 ACACB PRDM16 MEIS2	2.07e-05	181	40	4	bbe1e6e59d8889bd37d6e8303116cbdcafca7236
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NAV1 MUC16 SPAG17 PRDM16	2.30e-05	186	40	4	23b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCell	human_hepatoblastoma-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ACACB NFIA RBMS1 MBNL3	2.35e-05	187	40	4	f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	PHKA1 PRDM16 PTPRZ1 TPD52L1	2.35e-05	187	40	4	db2974e2e87ac9f1c2407a371d5ed89af09fc9b7
ToppCell	ASK440-Immune-Mast_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	DUSP14 NAV1 PHKA1 MEIS2	2.45e-05	189	40	4	72a19b20cb0f7283afe5f85d62a21cff69fd78d0
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DOCK3 PRDM16 PTPRZ1 TPD52L1	2.50e-05	190	40	4	625c08a0e5227efc46daa512fd579c3938ff76c7
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DOCK3 PRDM16 PTPRZ1 TPD52L1	2.60e-05	192	40	4	d3634574b2e8d2ded6446969361b70761b331aea
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DOCK3 PRDM16 PTPRZ1 TPD52L1	2.60e-05	192	40	4	25378b5e4b0cea8415ff125783511fc25a56fc00
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DOCK3 PRDM16 PTPRZ1 TPD52L1	2.60e-05	192	40	4	1aa5e4d9b32013a3f272561dcb8377f6805706df
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DOCK3 PRDM16 PTPRZ1 TPD52L1	2.66e-05	193	40	4	ab78fb1603ea6f720ba2d30148fe65dccf271fe1
ToppCell	Club_cells\|World / lung cells shred on cell class, cell subclass, sample id	MUC16 MUC5B NFIA PTPRZ1	2.66e-05	193	40	4	9d3165dc5763a07a7d873f497624d9d6528fa2db
ToppCell	Club_cells-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	MUC16 MUC5B NFIA PTPRZ1	2.66e-05	193	40	4	6582c0367052b9d10fb629c383ee0c55872afd2d
ToppCell	PCW_07-8.5-Epithelial\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DOCK3 PRDM16 PTPRZ1 TPD52L1	2.71e-05	194	40	4	f63ceedb88a9abc8644ee94adfd541e7817c1e3a
ToppCell	PCW_10-12-Epithelial-Epithelial_airway-epi_intermediate_(1)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	DOCK3 PRDM16 PTPRZ1 TPD52L1	2.77e-05	195	40	4	d67a2b489c29bfd575751c13d2a5b1efdec5240a
ToppCell	Control-Lymphoid-T\|Lymphoid / Disease state, Lineage and Cell class	RAPGEF6 LEF1 RBMS1 DISC1	2.77e-05	195	40	4	6687e579582d7a239bee80846de0cf827a6f6a62
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MUC16 MUC5B SPAG17 CDHR4	2.77e-05	195	40	4	9651ee03738226ee10e901f8b9ec6a417eb9c301
ToppCell	critical-Epithelial-Secretory\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	NFIA PTPRZ1 MEIS2 TPD52L1	2.82e-05	196	40	4	7da687eb983a54c28ee990424cc52e01caf5f4aa
ToppCell	IPF-Lymphoid-T\|Lymphoid / Disease state, Lineage and Cell class	RAPGEF6 LEF1 RBMS1 DISC1	2.82e-05	196	40	4	6e70c48a63d9673eb16b0847c1bd88eecc2f7a3c
ToppCell	COPD-Lymphoid-T\|Lymphoid / Disease state, Lineage and Cell class	RAPGEF6 LEF1 RBMS1 DISC1	2.82e-05	196	40	4	c9bdd505c3ab380ed7b272aa518df31a0a706a06
ToppCell	COVID-19-Epithelial-Club,_Basal_cells\|Epithelial / Condition, Lineage and Cell class	MUC16 MUC5B NFIA PTPRZ1	2.88e-05	197	40	4	78ed2810e5a765327e7a6da0ca5d4854bf7a0b6f
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Serous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK3 PTPRZ1 MEIS2 TPD52L1	3.05e-05	200	40	4	030efc36bbb848da31b0db3f74d46aac9c79cc9b
ToppCell	Tracheal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MUC16 MUC5B DTNB TPD52L1	3.05e-05	200	40	4	d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Macrophage_alveolar-Macro_alv_MT\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	AREL1 MUC12 RIMS2 MBNL3	3.05e-05	200	40	4	f11ae9055e72c938b6c9e52701478b2eee681ac4
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MUC16 MUC5B DTNB TPD52L1	3.05e-05	200	40	4	0eb9ad8c0373bcc62029ec21c590ed03aaacd039
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Serous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK3 PTPRZ1 DTNB TPD52L1	3.05e-05	200	40	4	7c2d499af60654b7b28f172ac2c914ad49fb74b4
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_B1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	DOCK3 CATSPERG PRDM16	1.62e-04	118	40	3	c351e465ece4f3767b2c19e695eca3c263c68777
ToppCell	LPS-antiTNF-Myeloid-Monocytes,_Macrophages-T-cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CNBD1 RIMS2 PTPRZ1	2.46e-04	136	40	3	186be8e1595608004b8216892cb9c7a7f31fbb4d
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal-Neurons\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	DUSP14 NFIA MEIS2	2.46e-04	136	40	3	b46450292e0cd549eb3bafdd3fed22f41d85bfbe
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MUC12 RIMS2 PTPRZ1	2.57e-04	138	40	3	2e46d546ad962aa0fde5b1c18c2a5370a4424e9f
ToppCell	URO-Lymphocyte-T_NK-CD8_TCM\|URO / Disease, Lineage and Cell Type	RIMS2 LEF1 TPD52L1	2.73e-04	141	40	3	53aef819f505238011f8a3202445f31055791d05
ToppCell	3'_v3-Lung-Lymphocytic_T_CD4-Tfh\|Lung / Manually curated celltypes from each tissue	RAPGEF6 SPAG17 LEF1	2.79e-04	142	40	3	319812c84fad93276bf093f2ad78db02ae745bf4
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Degenerative_Ascending_Thin_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MUC12 RIMS2 PTPRZ1	2.91e-04	144	40	3	163c591fedad2beb7f92531e6240e9554f90ea40
ToppCell	Healthy_donor-RBC\|World / disease group, cell group and cell class (v2)	TMPRSS9 GYPC MBNL3	3.28e-04	150	40	3	1e1a497ec4b048f7e9cc12dd5dd9aba7fedca9e1
ToppCell	COVID-19-Epithelial_cells-Airway_mucous\|COVID-19 / group, cell type (main and fine annotations)	MUC16 SPAG17 CDHR4	3.34e-04	151	40	3	8216462e723fec2797387929dde095370947e10a
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Poorly_Differentiated_or_Epithelioid_Leiomyosarcoma\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	RIMS2 MEIS2 TPD52L1	3.41e-04	152	40	3	6f9c343669883618cd9c1c8921a90c34d153f303
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NAV1 LEF1 MEIS2	3.54e-04	154	40	3	e51a5114f0ec38f997f5b8bbf3a7770f98595474
ToppCell	Healthy_donor-RBC\|Healthy_donor / disease group, cell group and cell class (v2)	TMPRSS9 GYPC MBNL3	3.54e-04	154	40	3	e080d5104fe6f3f6ef617bbcdccf1332ab7231e1
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_dendritic-CD141-positive_myeloid_dendritic_cell\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NAV1 BCL7A PRDM16	3.68e-04	156	40	3	2474402f563e9e9f37351cfabc8c012e42a1d8c5
ToppCell	3'_v3-bone_marrow-Lymphocytic_B-Pro-B\|bone_marrow / Manually curated celltypes from each tissue	TMPRSS9 BCL7A BAHCC1	3.68e-04	156	40	3	b093dbba6662e4fffc8aa577587b77f64ac44b56
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NAV1 PHKA1 MBNL3	3.68e-04	156	40	3	1928c86deb3bcd01db4ae76919a351066aadb39a
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	MUC16 SPAG17 CDHR4	3.68e-04	156	40	3	10d191e29b16cae8238e8df6c0ff38882253f34e
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Pld5\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	DUSP14 MEIS2 TPD52L1	3.89e-04	159	40	3	a082e770fa757c4a1d3ed13d53f83297e36faf05
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-CD1c+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	BCL7A PRDM16 CDHR4	3.89e-04	159	40	3	b3c52908cd24bbf851fac69db3850fc7f53c2092
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Cbln4_Fezf2\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	DUSP14 SSTR3 TPD52L1	3.96e-04	160	40	3	d8241404d775f9a709abdf17988f36293fcf4c58
ToppCell	10x5'v1-week_17-19-Lymphocytic_B-B_lineage-pro_B_progenitor\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	S1PR2 RIMS2 LEF1	3.96e-04	160	40	3	30b7f24e0c3ecfa618b4e31678e18c8a4405a8d7
ToppCell	Children_(3_yrs)-Epithelial-lung_goblet_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MUC16 MUC5B PTPRZ1	4.03e-04	161	40	3	2d63b279d9a5132e1c09b03930bf9039036d24a2
ToppCell	Healthy_donor-CD8+_T_naive\|World / disease group, cell group and cell class (v2)	LEF1 GYPC AMIGO1	4.03e-04	161	40	3	8a61395af33132783a0a37956c6f821aba5d3b1e
ToppCell	LPS-IL1RA-Epithelial_airway\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MUC5B SPAG17 PTPRZ1	4.03e-04	161	40	3	472c354f5ee148b37a5dfb795e83348ecb1643f1
ToppCell	3'_v3-bone_marrow-Lymphocytic_B-Pre-B\|bone_marrow / Manually curated celltypes from each tissue	NAV1 TMPRSS9 BCL7A	4.11e-04	162	40	3	e088e66aabc307dde5d2b9aa295c34ef68155b1a
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NFIA GYPC MEIS2	4.11e-04	162	40	3	58da6bc04cdac0002b0e6a751c96ff95e1a7f70f
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-B_cells-DZ_GC_cell\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMPRSS9 S1PR2 BCL7A	4.11e-04	162	40	3	3e15b3e97a2ade86d0cb0ab15fccb9a2e2e27dd4
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Ctxn3_Sla\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NFIA MEIS2 TPD52L1	4.11e-04	162	40	3	4d13c271b4f63cf32980e5643b5d5951165fe8b5
ToppCell	ICU-SEP-Lymphocyte-T_NK-CD4_Naive\|ICU-SEP / Disease, Lineage and Cell Type	SSTR3 LEF1 GYPC	4.18e-04	163	40	3	415e67aaae7ccd97a003b4b31b27eed94737deca
ToppCell	facs-Marrow-KLS-24m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK3 ACACB AVPR2	4.18e-04	163	40	3	b83a35c4426d66b5734a98fa6c72b345fe462030
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Ctxn3_Brinp3\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NFIA MEIS2 CDHR4	4.18e-04	163	40	3	b0aa4a620bd58011225b42ea6dda04e3101ba342
ToppCell	facs-Marrow-KLS-24m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK3 ACACB AVPR2	4.18e-04	163	40	3	c20ca9b6b4170ebcb0e66eef3e5d8ebff22b1a91
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MUC5B SPAG17 PTPRZ1	4.25e-04	164	40	3	e4d4c59aebe5cacd4ecdb907facd044dc82a831d
ToppCell	facs-Marrow-KLS-24m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK3 ACACB AVPR2	4.25e-04	164	40	3	d2b5f51af7fcffddebe997ee302bacbd85d76852
ToppCell	Ciliated_cells-B-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	MUC16 SPAG17 CDHR4	4.25e-04	164	40	3	0e9961acbb1d6c0089e6805ba6756736fa4d8bed
ToppCell	LPS-IL1RA-Epithelial_airway-Club_cells\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MUC5B PRDM16 PTPRZ1	4.33e-04	165	40	3	1a114eacaab598f755a173a3fed842ba91f689dd
ToppCell	5'-Adult-LymphNode-Hematopoietic-T_cells-TRGV5/7_gdT\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LEF1 RBMS1 GYPC	4.33e-04	165	40	3	207f9ca8839f54710e2112986def4bc7b0ef1a28
ToppCell	LPS-IL1RA-Epithelial_airway-Club_cells-Airway\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MUC5B PRDM16 PTPRZ1	4.33e-04	165	40	3	9cfd3c1d2c6d714fde83b90465f1f9741b0e50ce
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MUC5B PTPRZ1 BAHCC1	4.41e-04	166	40	3	60060b03f2abfa3cc08107ab5a9f578e60e4ae16
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MUC5B PTPRZ1 BAHCC1	4.41e-04	166	40	3	ec9161d388db5a257b8d125c14f9dd911d5d5d4a
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MUC5B PTPRZ1 BAHCC1	4.41e-04	166	40	3	4586d6725403f879fc96f67be579022587ce1906
ToppCell	LPS-antiTNF-Epithelial_airway-Club_cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MUC5B PRDM16 PTPRZ1	4.41e-04	166	40	3	1df4bdf7c773cbfa6c93d7a901f9cd3f3fe07a3d
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NAV1 LEF1 MEIS2	4.41e-04	166	40	3	8e5f2afbeffae5e77fcb29e8fe9f5aa49779b619
ToppCell	LPS-antiTNF-Epithelial_airway-Club_cells-Airway\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MUC5B PRDM16 PTPRZ1	4.41e-04	166	40	3	9628522e7af8f8edca733588a364ab2454ac5ca5
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_IT\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	DUSP14 SSTR3 TPD52L1	4.49e-04	167	40	3	f1ce6e64ebede1f3ef36fe982f46919fd1f814dd
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-Differentiating_glia\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMPRSS9 PTPRZ1 TPD52L1	4.49e-04	167	40	3	17c653b46507c8bb85da95836ae72a6015336142
ToppCell	P15-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	DUSP14 PRDM16 DTNB	4.49e-04	167	40	3	5c3d0763f73628c71c71f9883556bb4f1639f3cc
ToppCell	facs-Limb_Muscle-forelimb_and_hindlimb-18m-Lymphocytic-T_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DUSP14 AREL1 CATSPERG	4.56e-04	168	40	3	182f08106ac65ea501e2fb9139d3b44b7c4662c9
ToppCell	ASK428-Immune-Mast_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	DUSP14 NAV1 MEIS2	4.56e-04	168	40	3	c399fcb4d1d0be48026c2ecabc34a5935e7adf73
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MUC5B SPAG17 CDHR4	4.56e-04	168	40	3	9a8709d34865cfa668d8f3335dc34fc86fc32482
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SRRM5 RAPGEF6 MEIS2	4.64e-04	169	40	3	3f738fc56bbc70dc77c9ba41025631f8264cd2b3
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Club_cells-Airway\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MUC5B SPAG17 PTPRZ1	4.64e-04	169	40	3	86041be5d3aeab5b9269f7912791b944f325a1b4
ToppCell	facs-SCAT-Fat-18m-Lymphocytic-T_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAPGEF6 BCL7A LEF1	4.64e-04	169	40	3	700a3a36c379872585204caa6a6cc269b036ae22
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Club_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MUC5B SPAG17 PTPRZ1	4.64e-04	169	40	3	8c96e1baa38ec5e777e627ab9dbce025e771f2c0
ToppCell	NS-critical-d_0-4-Epithelial-Secretory\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MUC5B NANOG MEIS2	4.64e-04	169	40	3	aec97583b23112060437b619cb429dc32f29285f
ToppCell	Healthy_donor-CD8+_T_naive\|Healthy_donor / disease group, cell group and cell class (v2)	LEF1 GYPC AMIGO1	4.64e-04	169	40	3	66216758e581365f10c2a66714d83a606ad23af0
ToppCell	3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMPRSS9 PTPRZ1 TPD52L1	4.64e-04	169	40	3	2456b3e7776e8a2214972be1b4d66a3ca5480ae0
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MUC16 SPAG17 CDHR4	4.64e-04	169	40	3	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	Ciliated_cells-A-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	MUC16 SPAG17 CDHR4	4.72e-04	170	40	3	3d3a03979014df3a05c49be18010c6b94d786707
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-Deuterosomal\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	MUC12 SPAG17 CDHR4	4.81e-04	171	40	3	52aec5f6677fe2f7a36fb5b18117a4cffaeff58f
ToppCell	Ciliated_cells-B-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	MUC16 SPAG17 CDHR4	4.89e-04	172	40	3	187ae91148d293537afc77e10da2b64302322224
ToppCell	wk_20-22-Hematologic-Meg-ery-Definitive_erythrocyte\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	TMPRSS9 GYPC MBNL3	4.89e-04	172	40	3	f0b658baa4b41329c95a09387cc55ea046e2333f
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Differentiating_glia\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMPRSS9 PTPRZ1 TPD52L1	4.89e-04	172	40	3	bc3ed05fdd94d5e1f19285aea867b1453292baec
ToppCell	wk_20-22-Epithelial-Proximal_epithelial-Proximal_secretory_2\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	MUC16 MUC5B PTPRZ1	4.97e-04	173	40	3	d1e47c87bd4750801f3531f66a56c5dccb4ea64c
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell_prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NAV1 RBMS1 MEIS2	4.97e-04	173	40	3	f193c63cc536d891c9d23043765e320252bb6e65
ToppCell	Children_(3_yrs)-Epithelial-lung_goblet_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MUC16 MUC5B PTPRZ1	4.97e-04	173	40	3	464267a2ff3f5c387b6c9c6fa4dab135a221f448
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PHKA1 AREL1 PTPRZ1	4.97e-04	173	40	3	23e50492bc673aff9df95d97f0b9be4ce57cbf01
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_VWA2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NFIA MEIS2 TPD52L1	5.06e-04	174	40	3	43c0e758fa8683708475aec846929ac70d41d7f5
ToppCell	10x5'-blood-Lymphocytic_T_CD8-Tnaive/CM_CD8\|blood / Manually curated celltypes from each tissue	RAPGEF6 LEF1 GYPC	5.06e-04	174	40	3	8273de40552d1cca1a8fe3647fd5e4cb4bb70f99
Disease	colon cancer (implicated_via_orthology)	NANOGP8 NANOG	9.29e-05	11	39	2	DOID:219 (implicated_via_orthology)
Disease	stroke, major depressive disorder	AREL1 GYPC	2.87e-04	19	39	2	EFO_0000712, MONDO_0002009
Disease	celiac disease	NAV1 NFIA ZNF335	6.21e-04	126	39	3	EFO_0001060
Disease	thioredoxin domain-containing protein 12 measurement	DOCK3 CDHR4	1.22e-03	39	39	2	EFO_0008298
Disease	QRS complex, QRS duration	NFIA PRDM16	1.63e-03	45	39	2	EFO_0005054, EFO_0005055
Disease	Tourette syndrome	MUC16 RBMS1	2.00e-03	50	39	2	EFO_0004895
Disease	response to statin	PRDM16 DISC1	2.51e-03	56	39	2	GO_0036273
Disease	ovarian cancer (is_implicated_in)	MUC16 LEF1	2.51e-03	56	39	2	DOID:2394 (is_implicated_in)
Disease	optic disc size measurement	NAV1 CNBD1 PRDM16	2.51e-03	205	39	3	EFO_0004832
Disease	cocaine dependence	DOCK3 RIMS2	2.69e-03	58	39	2	EFO_0002610
Disease	Intellectual Disability	NFIA DISC1 MEIS2 ZNF335	2.81e-03	447	39	4	C3714756
Disease	cardiovascular disease	NAV1 S1PR2 PRDM16 BAHCC1	3.04e-03	457	39	4	EFO_0000319
Disease	cholangiocarcinoma (is_marker_for)	MUC16 MUC5B	3.26e-03	64	39	2	DOID:4947 (is_marker_for)
Disease	interstitial lung disease	NAV1 MUC5B	3.56e-03	67	39	2	EFO_0004244
Disease	schizophrenia (implicated_via_orthology)	RIMS2 DISC1	3.67e-03	68	39	2	DOID:5419 (implicated_via_orthology)
Disease	IGF-1 measurement	DOCK3 S1PR2 ACACB DTNB	3.85e-03	488	39	4	EFO_0004627

Protein segments in the cluster

Peptide	Gene	Start	Entry
SGISSMPSLRHSRMG	CATSPERG	1121	Q6ZRH7
SPLPMASHTASSRLM	BAHCC1	51	Q9P281
SSMLSTTPNHDPMAG	AMIGO1	416	Q86WK6
MSSRGHSTLPRTLMA	DUSP14	1	O95147
SLPTMGQMPGHSSDT	CCNT1	606	O60563
MHSLPDMDPGSSSSL	DISC1	291	Q9NRI5
THRTTVPSTMTPMLV	CDHR4	661	A6H8M9
TPMATMSTIHPSSTP	MUC5B	3086	Q9HC84
PMSTMSTIHTSSTPE	MUC5B	4771	Q9HC84
SMSPGAMRRSLPSTS	NFIA	256	Q12857
HPGAVLTPSMEHTMS	RBMS1	316	P29558
LTPSMEHTMSLQPAS	RBMS1	321	P29558
DTSMSRFSHHMIPGP	LEF1	236	Q9UJU2
ETRVPTMRPSMSGLH	ACACB	211	O00763
MSSAMSTKPTGASPS	MUC16	2296	Q8WXI7
LSNSPPMTISTHMTT	MUC16	4666	Q8WXI7
FPHSEMTTLMSRGPG	MUC16	7066	Q8WXI7
FSHSEMTTLMSRTPG	MUC16	8531	Q8WXI7
HRSPHSGMTTPMSRG	MUC16	8821	Q8WXI7
MTGQPTITFPISHSM	PHKA1	556	P46020
THPGMTMSAQSPTML	MEIS2	446	O14770
PGTRPTAMGSFSSHM	ARNTL2	31	Q8WYA1
PSLQMSSAEMPHTET	NANOG	36	Q9H9S0
PSSDAMMHARSSGPE	PTPRZ1	911	P23471
SISVTSPMSPGMLRD	RIMS2	786	Q9UQ26
LASHSPMSPESIKMT	DOCK3	1651	Q8IZD9
MVSHMSSGVPTPTKR	DTNB	346	O60941
PMHMTSSQRRPSTAV	AREL1	316	O15033
PMMHGATPTTVSAAT	MBNL3	321	Q9NUK0
LEPDPGMASASTTMH	GYPC	16	P04921
TTPENSSSPGMMDMH	BCL7A	76	Q4VC05
SSSLERGMHMPTSPT	S1PR2	331	O95136
HTMPMRSPSKLSHIS	NAV1	356	Q8NEY1
MMHNSLSRLPPASLS	RAPGEF6	1541	Q8TEU7
MDMLHPSSVSTTSEP	SSTR3	1	P32745
PSLQMSSAEMPHTET	NANOGP8	36	Q6NSW7
MMLSLSEDTPLHTPS	PRDM16	1236	Q9HAZ2
MPATPHSGDLMDSIS	SPAG17	1326	Q6Q759
LTASPHSMDSMLPSG	ARNTL	456	O00327
MPMSSLPAAILSHMT	CNBD1	1	Q8NA66
RMSPMGTASGSNSPT	ZFAND5	46	O76080
SMSLAPSGSSMPTAD	SRRM5	11	B3KS81
MPYTSSMPTAHRGSL	PRR19	241	A6NJB7
PMSPPSTTRMLATTS	TMPRSS9	741	Q7Z410
SIRHSISMPAMRNSP	TPD52L1	131	Q16890
PMTSPMSSSTLAHSL	ZNF335	176	Q9H4Z2
MLMASTTSAVPGHPS	AVPR2	1	P30518
PGSMHTTAFPSSTTM	MUC12	4366	Q9UKN1