Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	proline:proton symporter activity	SLC36A1 SLC36A2	2.05e-05	2	91	2	GO:0005297
GeneOntologyMolecularFunction	L-tyrosine transmembrane transporter activity	SLC36A1 SLC36A2	6.14e-05	3	91	2	GO:0005302
GeneOntologyMolecularFunction	calcium- and calmodulin-responsive adenylate cyclase activity	ADCY5 ADCY6	2.04e-04	5	91	2	GO:0008294
GeneOntologyMolecularFunction	amino acid:proton symporter activity	SLC36A1 SLC36A2	3.04e-04	6	91	2	GO:0005280
GeneOntologyMolecularFunction	L-proline transmembrane transporter activity	SLC36A1 SLC36A2	4.25e-04	7	91	2	GO:0015193
GeneOntologyMolecularFunction	L-alanine transmembrane transporter activity	SLC36A1 SLC36A2	7.24e-04	9	91	2	GO:0015180
GeneOntologyMolecularFunction	glycine transmembrane transporter activity	SLC36A1 SLC36A2	9.03e-04	10	91	2	GO:0015187
GeneOntologyMolecularFunction	RNA polymerase II CTD heptapeptide repeat kinase activity	CDK9 DYRK1A	9.03e-04	10	91	2	GO:0008353
GeneOntologyMolecularFunction	ATP hydrolysis activity	MDN1 NAIP ABCC11 ABCC12 AK9 CHD1L SRCAP DNAH7	9.11e-04	441	91	8	GO:0016887
GeneOntologyCellularComponent	IPAF inflammasome complex	NAIP NLRC4	1.12e-04	4	91	2	GO:0072557
Domain	ARM-type_fold	RELCH NCAPG UBQLN2 ARMC3 PIK3C2G ARMC12 ELMO1 IPO11 KPNB1 EFR3A	5.37e-06	339	90	10	IPR016024
Domain	-	RELCH NCAPG ARMC3 ARMC12 ELMO1 IPO11 KPNB1 EFR3A	1.18e-05	222	90	8	1.25.10.10
Domain	TRP_channel	TRPC7 TRPC6 TRPV2	1.74e-05	11	90	3	IPR004729
Domain	Med13_N	MED13L MED13	2.30e-05	2	90	2	PF11597
Domain	Mediator_Med13_N_met/fun	MED13L MED13	2.30e-05	2	90	2	IPR021643
Domain	Mediator_Med13	MED13L MED13	2.30e-05	2	90	2	IPR009401
Domain	Med13_C	MED13L MED13	2.30e-05	2	90	2	PF06333
Domain	ARM-like	RELCH NCAPG ARMC3 ARMC12 ELMO1 IPO11 KPNB1 EFR3A	4.79e-05	270	90	8	IPR011989
Domain	AAA+_ATPase	MDN1 NAIP ABCC11 ABCC12 AK9 DNAH7	6.92e-05	144	90	6	IPR003593
Domain	AAA	MDN1 NAIP ABCC11 ABCC12 AK9 DNAH7	6.92e-05	144	90	6	SM00382
Domain	Aa_trans	SLC38A10 SLC36A1 SLC36A2	7.01e-05	17	90	3	PF01490
Domain	AA_transpt_TM	SLC38A10 SLC36A1 SLC36A2	7.01e-05	17	90	3	IPR013057
Domain	TRP_dom	TRPC7 TRPC6	3.40e-04	6	90	2	IPR013555
Domain	Adcy_conserved_dom	ADCY5 ADCY6	3.40e-04	6	90	2	IPR009398
Domain	TRP_2	TRPC7 TRPC6	3.40e-04	6	90	2	PF08344
Domain	Ubiquilin	UBQLNL UBQLN2	3.40e-04	6	90	2	IPR015496
Domain	DUF1053	ADCY5 ADCY6	3.40e-04	6	90	2	PF06327
Domain	HEAT_REPEAT	RELCH NCAPG IPO11 KPNB1	3.63e-04	70	90	4	PS50077
Domain	TRPC_channel	TRPC7 TRPC6	4.75e-04	7	90	2	IPR002153
Domain	AC_N	ADCY5 ADCY6	6.31e-04	8	90	2	IPR032628
Domain	Adcy	ADCY5 ADCY6	6.31e-04	8	90	2	IPR030672
Domain	AC_N	ADCY5 ADCY6	6.31e-04	8	90	2	PF16214
Domain	Armadillo	ARMC3 ARMC12 KPNB1	1.51e-03	47	90	3	IPR000225
Domain	IMPORTIN_B_NT	IPO11 KPNB1	2.01e-03	14	90	2	PS50166
Domain	Ion_trans_dom	CACNA1F TRPC7 TRPC6 TRPV2	2.25e-03	114	90	4	IPR005821
Domain	Ion_trans	CACNA1F TRPC7 TRPC6 TRPV2	2.25e-03	114	90	4	PF00520
Domain	IBN_N	IPO11 KPNB1	2.31e-03	15	90	2	PF03810
Domain	IBN_N	IPO11 KPNB1	2.64e-03	16	90	2	SM00913
Domain	EF-hand-dom_pair	SLC25A24 CACNA1F DTNB CHP2 CAPN3 CCAR1	2.64e-03	287	90	6	IPR011992
Domain	HEAT	NCAPG IPO11 KPNB1	2.76e-03	58	90	3	IPR000357
Domain	HEAT_type_2	RELCH KPNB1	2.98e-03	17	90	2	IPR021133
Domain	A/G_cyclase_CS	ADCY5 ADCY6	2.98e-03	17	90	2	IPR018297
Domain	Importin-beta_N	IPO11 KPNB1	2.98e-03	17	90	2	IPR001494
Domain	Nucleotide_cyclase	ADCY5 ADCY6	3.34e-03	18	90	2	IPR029787
Domain	-	ADCY5 ADCY6	3.34e-03	18	90	2	3.30.70.1230
Domain	GUANYLATE_CYCLASE_1	ADCY5 ADCY6	3.72e-03	19	90	2	PS00452
Domain	Guanylate_cyc	ADCY5 ADCY6	3.72e-03	19	90	2	PF00211
Domain	GUANYLATE_CYCLASE_2	ADCY5 ADCY6	3.72e-03	19	90	2	PS50125
Domain	PRAME_family	PRAMEF7 PRAMEF8	3.72e-03	19	90	2	IPR026271
Domain	A/G_cyclase	ADCY5 ADCY6	3.72e-03	19	90	2	IPR001054
Domain	CYCc	ADCY5 ADCY6	3.72e-03	19	90	2	SM00044
Domain	-	CCAR1 PIAS2	4.54e-03	21	90	2	1.10.720.30
Domain	SAP	CCAR1 PIAS2	4.98e-03	22	90	2	PF02037
Domain	NACHT	NAIP NLRC4	5.44e-03	23	90	2	PS50837
Domain	SAP	CCAR1 PIAS2	5.44e-03	23	90	2	SM00513
Domain	NACHT_NTPase	NAIP NLRC4	5.44e-03	23	90	2	IPR007111
Domain	ABC_membrane	ABCC11 ABCC12	5.92e-03	24	90	2	PF00664
Domain	SAP	CCAR1 PIAS2	6.41e-03	25	90	2	PS50800
Domain	SAP_dom	CCAR1 PIAS2	6.41e-03	25	90	2	IPR003034
Domain	EF-hand_5	CHP2 CAPN3	6.41e-03	25	90	2	PF13202
Domain	NA-bd_OB-fold	CCAR1 DIS3 DARS2	7.53e-03	83	90	3	IPR012340
Domain	P-loop_NTPase	MDN1 MYH14 NAIP ABCC11 ABCC12 AK9 CHD1L SRCAP DNAH7 NLRC4	7.59e-03	848	90	10	IPR027417
Domain	ABC_TM1F	ABCC11 ABCC12	8.00e-03	28	90	2	PS50929
Domain	ABC1_TM_dom	ABCC11 ABCC12	8.00e-03	28	90	2	IPR011527
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	DYM DTNB ANKRD11 POLR1B CHD1L MED13L PIAS2 MED13 MAP3K4 IPO11	1.51e-06	538	91	10	10512203
Pubmed	Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters.	SLC36A1 SLC36A2	6.77e-06	2	91	2	11959859
Pubmed	Mediator complex component MED13 regulates zygotic genome activation and is required for postimplantation development in the mouse.	MED13L MED13	6.77e-06	2	91	2	29325037
Pubmed	The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation.	NAIP NLRC4	6.77e-06	2	91	2	17548639
Pubmed	Bacterial detection by NAIP/NLRC4 elicits prompt contractions of intestinal epithelial cell layers.	NAIP NLRC4	6.77e-06	2	91	2	33846244
Pubmed	Targeting Desulfovibrio vulgaris flagellin-induced NAIP/NLRC4 inflammasome activation in macrophages attenuates ulcerative colitis.	NAIP NLRC4	6.77e-06	2	91	2	37586642
Pubmed	Epithelium-intrinsic NAIP/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa.	NAIP NLRC4	6.77e-06	2	91	2	25121751
Pubmed	The N-end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin.	UBR2 UBE2O	6.77e-06	2	91	2	31268597
Pubmed	Cutting edge: Mouse NAIP1 detects the type III secretion system needle protein.	NAIP NLRC4	6.77e-06	2	91	2	24043898
Pubmed	Adenylyl cyclase subtype-specific compartmentalization: differential regulation of L-type Ca2+ current in ventricular myocytes.	ADCY5 ADCY6	6.77e-06	2	91	2	23609114
Pubmed	Adenylyl cyclase type 5 protein expression during cardiac development and stress.	ADCY5 ADCY6	6.77e-06	2	91	2	19734365
Pubmed	Knockout of adenylyl cyclase isoform 5 or 6 differentially modifies the β1-adrenoceptor-mediated inotropic response.	ADCY5 ADCY6	6.77e-06	2	91	2	31009605
Pubmed	Molecular basis for specific recognition of bacterial ligands by NAIP/NLRC4 inflammasomes.	NAIP NLRC4	6.77e-06	2	91	2	24657167
Pubmed	NAIP and Ipaf control Legionella pneumophila replication in human cells.	NAIP NLRC4	6.77e-06	2	91	2	18453601
Pubmed	Mechanosensitive cation currents through TRPC6 and Piezo1 channels in human pulmonary arterial endothelial cells.	PIEZO1 TRPC6	6.77e-06	2	91	2	35968892
Pubmed	Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12.	ABCC11 ABCC12	6.77e-06	2	91	2	11688999
Pubmed	Cryoelectron Tomography of the NAIP5/NLRC4 Inflammasome: Implications for NLR Activation.	NAIP NLRC4	6.77e-06	2	91	2	26585513
Pubmed	Structural and biochemical basis for induced self-propagation of NLRC4.	NAIP NLRC4	6.77e-06	2	91	2	26449475
Pubmed	The structural basis of flagellin detection by NAIP5: A strategy to limit pathogen immune evasion.	NAIP NLRC4	6.77e-06	2	91	2	29146805
Pubmed	The calcium paradoxon of renin release: calcium suppresses renin exocytosis by inhibition of calcium-dependent adenylate cyclases AC5 and AC6.	ADCY5 ADCY6	6.77e-06	2	91	2	17068292
Pubmed	NAIP proteins are required for cytosolic detection of specific bacterial ligands in vivo.	NAIP NLRC4	6.77e-06	2	91	2	27045008
Pubmed	Formation and structure of a NAIP5-NLRC4 inflammasome induced by direct interactions with conserved N- and C-terminal regions of flagellin.	NAIP NLRC4	6.77e-06	2	91	2	23012363
Pubmed	Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia.	ADCY5 ADCY6	6.77e-06	2	91	2	31162142
Pubmed	Crystal structure of NLRC4 reveals its autoinhibition mechanism.	NAIP NLRC4	6.77e-06	2	91	2	23765277
Pubmed	Differential regulation of vascular tone and remodeling via stimulation of type 2 and type 6 adenylyl cyclases in the ductus arteriosus.	ADCY5 ADCY6	6.77e-06	2	91	2	20431059
Pubmed	Molecular determinants for cardiovascular TRPC6 channel regulation by Ca2+/calmodulin-dependent kinase II.	TRPC7 TRPC6	6.77e-06	2	91	2	23529130
Pubmed	Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12.	ABCC11 ABCC12	6.77e-06	2	91	2	11483364
Pubmed	Stimulation of renin secretion by catecholamines is dependent on adenylyl cyclases 5 and 6.	ADCY5 ADCY6	6.77e-06	2	91	2	21282557
Pubmed	Genetic functions of the NAIP family of inflammasome receptors for bacterial ligands in mice.	NAIP NLRC4	6.77e-06	2	91	2	27114610
Pubmed	Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation.	NAIP NLRC4	6.77e-06	2	91	2	23940371
Pubmed	Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues.	ADCY5 ADCY6	6.77e-06	2	91	2	10481931
Pubmed	Differential requirements for NAIP5 in activation of the NLRC4 inflammasome.	NAIP NLRC4	6.77e-06	2	91	2	21282416
Pubmed	PLC-mediated PI(4,5)P2 hydrolysis regulates activation and inactivation of TRPC6/7 channels.	TRPC7 TRPC6	6.77e-06	2	91	2	24470487
Pubmed	Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects.	SLC38A10 SLC36A1 SLC36A2	7.71e-06	15	91	3	23506890
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RELCH UBE2O SULF2 KDM5C PIEZO1 DNMBP DIS3 MED13 EFR3A	1.06e-05	529	91	9	14621295
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	DYM DTNB ANKRD11 CHD1L MED13L PIAS2 MED13 MAP3K4 IPO11	1.17e-05	536	91	9	15840001
Pubmed	Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity.	NAIP NLRC4	2.03e-05	3	91	2	21874021
Pubmed	Inflammasome activation and CCR2-mediated monocyte-derived dendritic cell recruitment restrict Legionella pneumophila infection.	NAIP NLRC4	2.03e-05	3	91	2	36427489
Pubmed	Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6.	ADCY5 ADCY6	2.03e-05	3	91	2	31173603
Pubmed	Birc1e/Naip5 rapidly antagonizes modulation of phagosome maturation by Legionella pneumophila.	NAIP NLRC4	2.03e-05	3	91	2	17087731
Pubmed	Organization and expression of the SLC36 cluster of amino acid transporter genes.	SLC36A1 SLC36A2	2.03e-05	3	91	2	15058382
Pubmed	Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes.	ADCY5 ADCY6	2.03e-05	3	91	2	16973443
Pubmed	Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in polycystic liver disease.	ADCY5 ADCY6	2.03e-05	3	91	2	27826057
Pubmed	A cluster of proton/amino acid transporter genes in the human and mouse genomes.	SLC36A1 SLC36A2	2.03e-05	3	91	2	12809675
Pubmed	Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.	NAIP NLRC4	2.03e-05	3	91	2	26449474
Pubmed	Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries.	TRPC7 TRPC6	2.03e-05	3	91	2	28526717
Pubmed	Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI.	ADCY5 ADCY6	2.03e-05	3	91	2	8034296
Pubmed	Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin.	NAIP NLRC4	2.03e-05	3	91	2	18724372
Pubmed	A novel pathway for inducible nitric-oxide synthase activation through inflammasomes.	NAIP NLRC4	2.03e-05	3	91	2	20702413
Pubmed	Inflammasome activation restricts Legionella pneumophila replication in primary microglial cells through flagellin detection.	NAIP NLRC4	2.03e-05	3	91	2	23355222
Pubmed	NAIP-NLRC4-deficient mice are susceptible to shigellosis.	NAIP NLRC4	2.03e-05	3	91	2	33074100
Pubmed	Amyloid beta induces cellular relocalization and production of agrin and glypican-1.	GPC1 AGRN	2.03e-05	3	91	2	19166823
Pubmed	Gq-mediated Ca2+ signals inhibit adenylyl cyclases 5/6 in vascular smooth muscle cells.	ADCY5 ADCY6	2.03e-05	3	91	2	19889965
Pubmed	The Retinal Basis of Light Aversion in Neonatal Mice.	TRPC7 TRPC6	2.03e-05	3	91	2	35396331
Pubmed	Regulation of type V adenylate cyclase by Ric8a, a guanine nucleotide exchange factor.	ADCY5 ADCY6	2.03e-05	3	91	2	17593019
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	CDK9 SLC38A10 MDN1 PIEZO1 DYRK1A ANKRD11 C19orf44 MED13L SRCAP DNMBP AGRN MED13	3.12e-05	1105	91	12	35748872
Pubmed	Mapping the expression of transient receptor potential channels across murine placental development.	TRPC7 TRPC6 TRPV2	3.37e-05	24	91	3	33884443
Pubmed	International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.	TRPC7 TRPC6 TRPV2	3.82e-05	25	91	3	16382100
Pubmed	Phase-separation mechanism for C-terminal hyperphosphorylation of RNA polymerase II.	CDK9 DYRK1A	4.05e-05	4	91	2	29849146
Pubmed	Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5.	NAIP NLRC4	4.05e-05	4	91	2	25605939
Pubmed	Differential dopamine receptor subtype regulation of adenylyl cyclases in lipid rafts in human embryonic kidney and renal proximal tubule cells.	ADCY5 ADCY6	4.05e-05	4	91	2	25049074
Pubmed	The NAIP-NLRC4 inflammasome in innate immune detection of bacterial flagellin and type III secretion apparatus.	NAIP NLRC4	4.05e-05	4	91	2	25879286
Pubmed	Melanopsin Phototransduction Is Repurposed by ipRGC Subtypes to Shape the Function of Distinct Visual Circuits.	TRPC7 TRPC6	4.05e-05	4	91	2	30017393
Pubmed	Inflammasomes: mechanism of action, role in disease, and therapeutics.	NAIP NLRC4	4.05e-05	4	91	2	26121197
Pubmed	The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.	NAIP NLRC4	4.05e-05	4	91	2	21918512
Pubmed	Listeria monocytogenes engineered to activate the Nlrc4 inflammasome are severely attenuated and are poor inducers of protective immunity.	NAIP NLRC4	4.05e-05	4	91	2	21746921
Pubmed	FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment.	MED13L MED13	4.05e-05	4	91	2	29809150
Pubmed	An introduction to TRP channels.	TRPC7 TRPC6 TRPV2	4.84e-05	27	91	3	16460286
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	PRAMEF7 MDN1 CAPN3 PRAMEF8 SRCAP DIS3 LARGE1	4.86e-05	363	91	7	14691545
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	UBE2O NCAPG MYH14 DYRK1A CCAR1 CHD1L MED13L SRCAP MED13	4.98e-05	645	91	9	25281560
Pubmed	2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3.	TRPC6 TRPV2	6.74e-05	5	91	2	15194687
Pubmed	TRPC channels are necessary mediators of pathologic cardiac hypertrophy.	TRPC7 TRPC6	6.74e-05	5	91	2	20351294
Pubmed	The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response.	TLR9 NLRC4	6.74e-05	5	91	2	18288107
Pubmed	Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex.	NAIP NLRC4	6.74e-05	5	91	2	24803432
Pubmed	Intrinsic phototransduction persists in melanopsin-expressing ganglion cells lacking diacylglycerol-sensitive TRPC subunits.	TRPC7 TRPC6	6.74e-05	5	91	2	21261756
Pubmed	Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains.	ADCY5 ADCY6	6.74e-05	5	91	2	21228062
Pubmed	Salmonella enterica Serovar Typhimurium Induces NAIP/NLRC4- and NLRP3/ASC-Independent, Caspase-4-Dependent Inflammasome Activation in Human Intestinal Epithelial Cells.	NAIP NLRC4	6.74e-05	5	91	2	35678562
Pubmed	Role and regulation of TRP channels in neutrophil granulocytes.	TRPC6 TRPV2	6.74e-05	5	91	2	12765698
Pubmed	Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4.	NAIP NLRC4	6.74e-05	5	91	2	19720760
Pubmed	Arsenic trioxide and other arsenical compounds inhibit the NLRP1, NLRP3, and NAIP5/NLRC4 inflammasomes.	NAIP NLRC4	6.74e-05	5	91	2	24337744
Pubmed	Dystroglycan mediates homeostatic synaptic plasticity at GABAergic synapses.	AGRN LARGE1	6.74e-05	5	91	2	24753587
Pubmed	A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.	TRPC7 TRPC6 TRPV2	8.93e-05	33	91	3	19834762
Pubmed	Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome.	TLR9 NLRC4	1.01e-04	6	91	2	19164858
Pubmed	Evolutionary development of redundant nuclear localization signals in the mRNA export factor NXF1.	IPO11 KPNB1	1.01e-04	6	91	2	21965294
Pubmed	Mouse macrophages are permissive to motile Legionella species that fail to trigger pyroptosis.	NAIP NLRC4	1.01e-04	6	91	2	19841075
Pubmed	Rapid induction of inflammatory lipid mediators by the inflammasome in vivo.	NAIP NLRC4	1.01e-04	6	91	2	22902502
Pubmed	Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle.	ADCY5 ADCY6	1.01e-04	6	91	2	24944202
Pubmed	Mapping of adenylyl cyclase genes type I, II, III, IV, V, and VI in mouse.	ADCY5 ADCY6	1.01e-04	6	91	2	7766992
Pubmed	Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland.	ADCY5 ADCY6	1.01e-04	6	91	2	11549699
Pubmed	Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkcδ.	NAIP NLRC4	1.01e-04	6	91	2	24516390
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	UBR2 DYM IMPA2 PDE9A MYH14 DTNB NAIP ANKRD11 CCAR1 CHD1L ZSWIM4 VPS13B DOP1A	1.32e-04	1489	91	13	28611215
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	CACNA1F TRPC7 TRPC6	1.37e-04	38	91	3	30786075
Pubmed	MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC.	TRPC7 TRPC6	1.41e-04	7	91	2	15757897
Pubmed	Coexistence within one cell of microvillous and ciliary phototransductions across M1- through M6-IpRGCs.	TRPC7 TRPC6	1.41e-04	7	91	2	38109525
Pubmed	RNA-seq analysis reveals TRPC genes to impact an unexpected number of metabolic and regulatory pathways.	TRPC7 TRPC6	1.41e-04	7	91	2	32350291
Pubmed	Differential expression of adenylyl cyclase mRNAs in lacrimal glands of NZB/NZW and NOD pre-autoimmune mice.	ADCY5 ADCY6	1.41e-04	7	91	2	12613887
Pubmed	TRPC absence induces pro-inflammatory macrophages and gut microbe disorder, sensitizing mice to colitis.	TRPC7 TRPC6	1.41e-04	7	91	2	36592529
Pubmed	Functional role of TRPC proteins in vivo: lessons from TRPC-deficient mouse models.	TRPC7 TRPC6	1.41e-04	7	91	2	15336983
Pubmed	The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development.	MED13L MED13	1.41e-04	7	91	2	12093747
Pubmed	TRPC absence induces pro-inflammatory macrophage polarization to promote obesity and exacerbate colorectal cancer.	TRPC7 TRPC6	1.41e-04	7	91	2	38835669
GeneFamily	Ubiquilin family	UBQLNL UBQLN2	1.47e-04	5	70	2	783
GeneFamily	Transient receptor potential cation channels	TRPC7 TRPC6 TRPV2	1.70e-04	28	70	3	249
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	ARMC3 ARMC12 KPNB1	6.14e-04	43	70	3	409
GeneFamily	Adenylate cyclases\|Deafness associated genes	ADCY5 ADCY6	6.52e-04	10	70	2	53
GeneFamily	ATP binding cassette subfamily C	ABCC11 ABCC12	1.12e-03	13	70	2	807
GeneFamily	Armadillo repeat containing\|Importins	IPO11 KPNB1	2.17e-03	18	70	2	596
GeneFamily	PRAME family	PRAMEF7 PRAMEF8	3.86e-03	24	70	2	686
GeneFamily	NLR family	NAIP NLRC4	4.18e-03	25	70	2	666
GeneFamily	Solute carriers	SLC25A24 SLC17A2 SLC38A10 SLC36A1 SLC36A2 SLC5A2	4.23e-03	395	70	6	752
GeneFamily	Cyclins\|Mediator complex	MED13L MED13	7.22e-03	33	70	2	1061
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#3_top-relative-expression-ranked_1000	RELCH DYRK1A DNMBP AGRN MED13 VPS13B ELMO1 KPNB1 EFR3A	1.53e-05	369	84	9	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k3_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#2_top-relative-expression-ranked_500	RELCH DYRK1A DNMBP AGRN MED13 KPNB1 EFR3A	1.93e-05	209	84	7	gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_500_k2
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#4_top-relative-expression-ranked_1000	RELCH KDM5C DYRK1A DNMBP AGRN MED13 VPS13B KPNB1 EFR3A	2.14e-05	385	84	9	gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000_k4
CoexpressionAtlas	DevelopingKidney_e15.5_stage III -IV renal corpusc_emap-27945_k-means-cluster#4_top-relative-expression-ranked_500	PARD6B RELCH AGRN MED13 EFR3A	6.36e-05	106	84	5	gudmap_developingKidney_e15.5_stage III -IV renal corpusc_500_k4
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TRPC7 PDE9A ARMC3 PIK3C2G PIEZO1 OR14A16 TMEM101	2.67e-08	151	91	7	f4f7156b2c0cfc78fd1841e07c9915d97ced561f
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	UBR2 DYM DTNB FER DYRK1A MED13L VPS13B	1.76e-07	199	91	7	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
Disease	Neurodevelopmental Disorders	DYRK1A ANKRD11 MED13L SRCAP ADCY5	8.89e-06	93	88	5	C1535926
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	CACNA1F DTNB CAPN3	1.70e-04	36	88	3	DOID:11723 (implicated_via_orthology)
Disease	Epilepsy	FOLR1 KDM5C DYRK1A ANKRD11	3.24e-04	109	88	4	C0014544
Disease	Intellectual Disability	LINS1 OR5M1 FOLR1 KDM5C MED13L MED13 LARGE1	3.86e-04	447	88	7	C3714756
Disease	response to ondansetron, QT interval	SLC36A1 SLC36A2	4.75e-04	11	88	2	EFO_0004682, EFO_0020997
Disease	nicotine dependence (implicated_via_orthology)	TRPC7 TRPC6	5.69e-04	12	88	2	DOID:0050742 (implicated_via_orthology)
Disease	Mental Retardation, Psychosocial	LINS1 FOLR1 KDM5C MED13L	8.09e-04	139	88	4	C0025363
Disease	Profound Mental Retardation	LINS1 FOLR1 KDM5C MED13L	8.09e-04	139	88	4	C0020796
Disease	Mental deficiency	LINS1 FOLR1 KDM5C MED13L	8.09e-04	139	88	4	C0917816
Disease	Down syndrome (implicated_via_orthology)	DYRK1A DOP1A	9.00e-04	15	88	2	DOID:14250 (implicated_via_orthology)
Disease	syndromic intellectual disability (implicated_via_orthology)	KDM5C DYRK1A	1.03e-03	16	88	2	DOID:0050888 (implicated_via_orthology)
Disease	Congenital Myasthenic Syndromes, Postsynaptic	AK9 AGRN	1.16e-03	17	88	2	C0751883
Disease	intellectual disability (implicated_via_orthology)	KDM5C CAPN3 DYRK1A	1.48e-03	75	88	3	DOID:1059 (implicated_via_orthology)
Disease	Epilepsy, Cryptogenic	FOLR1 DYRK1A ANKRD11	1.91e-03	82	88	3	C0086237
Disease	Awakening Epilepsy	FOLR1 DYRK1A ANKRD11	1.91e-03	82	88	3	C0751111
Disease	Aura	FOLR1 DYRK1A ANKRD11	1.91e-03	82	88	3	C0236018
Disease	myeloid white cell count	SLC25A24 UBR2 UBE2O PIEZO1 TRPC6 NAIP DYRK1A POLR1B ADCY5	1.92e-03	937	88	9	EFO_0007988

Protein segments in the cluster

Peptide	Gene	Start	Entry
MELNGSSSQLIIMLL	TDRD1	1061	Q9BXT4
MLEILMTVFSASQRI	NAIP	1016	Q13075
VLQVLTFNLLEDRMM	ELMO1	296	Q92556
LSERQQVALLMQMTA	ANKRD11	111	Q6UB99
TQMITINRDLLMAFV	CCAR1	916	Q8IX12
QMNQSSLTLLMAVLV	ADCY6	146	O43306
ELMLNSSLMRITLRN	AGRN	131	O00468
QMMSIEILTLLFTEL	DOP1A	1486	Q5JWR5
NMELQQLREMTLLSS	DNMBP	746	Q6XZF7
VLTNMAMQEPLRLNI	ARMC3	421	Q5W041
LTNQVMPDIVMLQRR	DYRK1A	66	Q13627
RLNQSSLTMLMAVLV	ADCY5	236	O95622
RIQIMLLRSLLMVTS	EFR3A	431	Q14156
QLRRVMPALMEILQS	ARMC12	186	Q5T9G4
IMSVLNSMLQSLVTL	OR7A2P	151	Q8NGA2
LRQDMLVLQLIQVMD	PIK3C2G	926	O75747
VTDMMIANSRNLIIT	PARD6B	231	Q9BYG5
RRKMISTLQQLLMQT	DZIP1L	146	Q8IYY4
RSSLVLSMLQQMLME	RELCH	636	Q9P260
MFLLILLNTVALAMQ	CACNA1F	1196	O60840
VQSLQLQERMMSLLE	MSANTD1	256	Q6ZTZ1
LVAQLSMDRLQMLEA	LARGE1	476	O95461
QMTLMLLVSTLQAFI	MDN1	3861	Q9NU22
QMSGSREVMLLQLTV	LINS1	81	Q8NG48
SMLSSQDVVRMLLSL	MED13L	1316	Q71F56
LIDRMNVLEQLTALM	NLRC4	871	Q9NPP4
QIMQLKIMTNRLRSA	GPC1	456	P35052
NQTLTPVLLEMMQTL	IPO11	421	Q9UI26
EIISMLRMVSAVLQF	MYH14	361	Q7Z406
LITMNRRVCVLMLLA	OR4A15	161	Q8NGL6
QIRQGMITLILATDM	PDE9A	411	O76083
LVLTMLTCLIIIMQN	ENPP4	416	Q9Y6X5
MALRLEIMTNLVTLA	ABCC11	1046	Q96J66
IRIQMRALDMLQMAS	FAM161B	316	Q96MY7
TREMAMLIAQALQTI	IMPA2	266	O14732
LKTVLMIAIQLISRM	CSNK1G3	136	Q9Y6M4
VIRMMLEIINSCLTN	DYM	531	Q7RTS9
WLLMIQQTEQLSRIM	FER	71	P16591
NAALMKLAQLETRIM	C19orf44	91	Q9H6X5
VLLFSQMTQMLDILQ	CHD1L	366	Q86WJ1
ALMTLQLQDLTLVSM	DNAH7	366	Q8WXX0
MSALQESRRELMVQL	DTNB	496	O60941
MLSQLAMLQGSLLLV	ANGPT4	1	Q9Y264
LGVVQILTALMSLSM	MS4A4A	66	Q96JQ5
TLVIMERLQQVLQME	KPNB1	551	Q14974
LQISDVVMASLLRMF	KPNB1	601	Q14974
LIARMVRNMDNSLLQ	CAPN3	286	P20807
FTLSEIKRVMQMLLN	CDK9	121	P50750
LLRCLQASLEMVVMT	PRAMEF8	286	Q5VWM4
QMQMTEQICRQVLLL	SALL2	196	Q9Y467
IVLPLSLQRNMMASI	SLC38A10	136	Q9HBR0
MAQRMTTQLLLLLVW	FOLR1	1	P15328
IMSVTENTLMILLIR	OR2AJ1	36	Q8NGZ0
VRQLTSAMLLQRLKM	PIAS2	296	O75928
ALMGNVLIIMITTLD	OR14A16	36	Q8NHC5
TLRSMQVDNLLLVVM	MAP3K4	936	Q9Y6R4
LTQATASMILLMAIL	MT-ND2	61	P03891
VSRIALQSLMMLEIT	TAS2R39	81	P59534
QMNLLEARSIIPMVI	AK9	1506	Q5TCS8
NFIMESQRLELIRLM	DARS2	416	Q6PI48
VTMSRILRLKIQMQE	RNF8	251	O76064
SLRNTDVILAMQQMI	OR5M1	291	Q8NGP8
LRILTIFSMLANISM	SLC36A2	221	Q495M3
RSMFNTILLTIIAMV	SPTSSB	31	Q8NFR3
SMQCSQDILRMLLSL	MED13	1271	Q9UHV7
RVLIFTQMTRMLDVL	SRCAP	2061	Q6ZRS2
ALRMDVLMNILTFTV	ABCC12	1026	Q96J65
LNTLLRILATRCMMQ	DIS3	736	Q9Y2L1
IQLMDRLSNESIMLV	STRC	1266	Q7RTU9
MSIAQRVMLLQQGLN	NCAPG	241	Q9BPX3
MLQVLRLMVGVQVTE	CHP2	136	O43745
LFSRSMNTQILLMAV	C12orf60	36	Q5U649
LLRCLQASLEMVVMT	PRAMEF7	286	Q5VXH5
SLLANITMLVSLVMI	SLC36A1	221	Q7Z2H8
RVVNLNALLMMAVAV	SLC5A2	651	P31639
LSLLVQAIMLAMTLA	TLR9	11	Q9NR96
MITQRVSLSIAIIAM	SLC17A2	31	O00624
NEMALIRVVQSMTQL	UBE2O	1101	Q9C0C9
LLLNMLIALMSETVN	TRPV2	636	Q9Y5S1
LELARNLAMIQEIMQ	UBQLNL	226	Q8IYU4
ITDQQLPMFIRIMQL	VPS13B	266	Q7Z7G8
VMLLIQFSTMVVDRA	PIEZO1	2006	Q92508
VIVLLNMLIAMINSS	TRPC6	716	Q9Y210
VQSMLSNPDLMRQLI	UBQLN2	191	Q9UHD9
LTLSLQRQMMENLVI	VPS9D1	181	Q9Y2B5
SFLRNSVSQMLRIVM	POLR1B	276	Q9H9Y6
TLARMLITEENLMSI	UBR2	426	Q8IWV8
ILQSDVMLCIMGTIL	UBR2	891	Q8IWV8
LALVRTRMQAQAMLE	SLC25A24	406	Q6NUK1
TNMLQRKRLQTLMSV	SULF2	276	Q8IWU5
MLQLIMQLGSVLLTR	TMEM101	11	Q96IK0
VVVLLNMLIAMINNS	TRPC7	661	Q9HCX4
RMLILMTEQFLQDTR	ZSWIM4	301	Q9H7M6
LQMTLTELRAFLDQM	KDM5C	846	P41229