Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontranscription coactivator activity

ZXDC ASXL1 DCAF6 NACA JMY KMT2D TADA2B PKN1 MTDH

3.70e-053031079GO:0003713
GeneOntologyMolecularFunctionmolecular adaptor activity

BICD2 ZXDC ASXL1 DCAF6 SPAG4 TCERG1L NACA AHDC1 JMY BICD1 WWC2 KMT2D FBXO3 TADA2B MAP3K10 PKP2 GIGYF2 PKN1 MTDH

9.87e-05135610719GO:0060090
GeneOntologyMolecularFunctiontranscription coregulator activity

ZXDC ASXL1 DCAF6 TCERG1L NACA JMY KMT2D TADA2B MAP3K10 PKN1 MTDH

2.15e-0456210711GO:0003712
GeneOntologyMolecularFunctionstructural constituent of nuclear pore

POM121L2 POM121 NUP188

3.16e-04251073GO:0017056
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

BICD2 ZXDC ASXL1 DCAF6 SPAG4 TCERG1L NACA JMY BICD1 WWC2 KMT2D FBXO3 TADA2B MAP3K10 PKN1 MTDH

4.44e-04116010716GO:0030674
GeneOntologyCellularComponentPR-DUB complex

ASXL1 ASXL2

1.55e-0441072GO:0035517
GeneOntologyCellularComponentGolgi lumen

HSPG2 MUC15 MUC16 MUC17 MUC2

2.45e-041091075GO:0005796
HumanPhenoAbnormal cerebral white matter morphology

BICD2 HSPG2 ASXL1 MAP1B SZT2 PCLO IQSEC2 HECTD4 MINPP1 AHDC1 NECAP1 KMT2D CC2D2A ZFYVE26 ATP11A ASXL2 NUP188 NOTCH3

2.28e-0511143218HP:0002500
HumanPhenoAbnormal corpus callosum morphology

BICD2 HSPG2 ASXL1 MAP1B SZT2 PCLO IQSEC2 HECTD4 MINPP1 AHDC1 NECAP1 KMT2D CC2D2A ZFYVE26 ATP11A NUP188

4.72e-059373216HP:0001273
HumanPhenoApnea

BICD2 HSPG2 ASXL1 IQSEC2 MINPP1 AHDC1 SCO1 CC2D2A HERC2 NOTCH3

5.74e-053723210HP:0002104
HumanPhenoAbnormal cerebral subcortex morphology

BICD2 HSPG2 ASXL1 MAP1B SZT2 PCLO IQSEC2 HECTD4 MINPP1 AHDC1 NECAP1 KMT2D CC2D2A ZFYVE26 ATP11A ASXL2 NUP188 NOTCH3

7.20e-0512073218HP:0010993
HumanPhenoAbnormal calvaria morphology

HSPG2 ASXL1 MAP1B SZT2 PCLO IQSEC2 ASH1L HECTD4 AHDC1 NECAP1 KMT2D SEC24C CC2D2A NUP188 HERC2 SLX4 SEC23A NOTCH3

1.23e-0412543218HP:0002683
HumanPhenoAbnormality of calvarial morphology

HSPG2 ASXL1 SZT2 PCLO IQSEC2 ASH1L HECTD4 AHDC1 NECAP1 KMT2D SEC24C CC2D2A NUP188 HERC2 SLX4 SEC23A NOTCH3

1.29e-0411343217HP:0002648
HumanPhenoAutism

HSPG2 SZT2 IQSEC2 HECTD4 AHDC1 NECAP1 SEC24C HERC2

1.66e-04264328HP:0000717
HumanPhenoAbnormality of prenatal development or birth

BICD2 HSPG2 ASXL1 SZT2 IQSEC2 ASH1L NECAP1 KMT2D SLC12A3 SEC24C KCNH2 CC2D2A ASXL2 NUP188 HERC2 IL2RG SLX4

1.72e-0411593217HP:0001197
HumanPhenoGastroesophageal reflux

HSPG2 ASXL1 MAP1B SZT2 IQSEC2 HECTD4 NECAP1 KMT2D SEC24C ATP11A SEC23A

1.87e-045173211HP:0002020
HumanPhenoAbnormal hair morphology

HSPG2 ASXL1 MAP1B SZT2 IQSEC2 ASH1L HECTD4 BNC1 KMT2D SEC24C HPS4 CC2D2A ASXL2 NUP188 HERC2 IL2RG SLX4 SEC23A NOTCH3

1.87e-0414243219HP:0001595
HumanPhenoAbnormal esophagus physiology

HSPG2 ASXL1 MAP1B SZT2 IQSEC2 HECTD4 MINPP1 NECAP1 KMT2D SEC24C GIGYF2 ZFYVE26 ATP11A SEC23A NOTCH3

1.96e-049333215HP:0025270
DomainDUF4599

SPATA31C2 SPATA31C1 SPATA31D4 SPATA31D1 SPATA31D3

4.11e-09121065PF15371
DomainDUF4599

SPATA31C2 SPATA31C1 SPATA31D4 SPATA31D1 SPATA31D3

4.11e-09121065IPR027970
DomainBicaudal-D_microtubule-assoc

BICD2 BICD1

3.19e-0521062IPR018477
DomainBicD

BICD2 BICD1

3.19e-0521062PF09730
DomainSEA

HSPG2 MUC16 MUC17

6.18e-05141063SM00200
DomainHARE-HTH

ASXL1 ASXL2

9.54e-0531062PF05066
DomainASXH

ASXL1 ASXL2

9.54e-0531062PF13919
DomainPHD_3

ASXL1 ASXL2

9.54e-0531062PF13922
DomainASX-like_PHD

ASXL1 ASXL2

9.54e-0531062IPR026905
DomainASX/ASX-like

ASXL1 ASXL2

9.54e-0531062IPR024811
DomainASXH

ASXL1 ASXL2

9.54e-0531062IPR028020
DomainHB1/Asxl_HTH

ASXL1 ASXL2

9.54e-0531062IPR007759
DomainSEA

HSPG2 MUC16 MUC17

2.53e-04221063PF01390
DomainSEA

HSPG2 MUC16 MUC17

2.90e-04231063PS50024
DomainSEA_dom

HSPG2 MUC16 MUC17

2.90e-04231063IPR000082
DomainSec23/24_helical_dom

SEC24C SEC23A

4.72e-0461062IPR006900
DomainSec23_24_beta_S

SEC24C SEC23A

4.72e-0461062IPR012990
Domainzf-Sec23_Sec24

SEC24C SEC23A

4.72e-0461062PF04810
DomainSec23_trunk

SEC24C SEC23A

4.72e-0461062PF04811
DomainSec23_helical

SEC24C SEC23A

4.72e-0461062PF04815
DomainSec23_BS

SEC24C SEC23A

4.72e-0461062PF08033
DomainSec23/24_trunk_dom

SEC24C SEC23A

4.72e-0461062IPR006896
DomainZnf_Sec23_Sec24

SEC24C SEC23A

4.72e-0461062IPR006895
DomainC2

PCLO WWC2 ESYT2 CC2D2A PKN1

1.30e-031421065PS50004
Domain-

PCLO WWC2 ESYT2 CC2D2A PKN1

1.56e-0314810652.60.40.150
DomainZF_PHD_2

ASXL1 ASH1L KMT2D ASXL2

2.10e-03951064PS50016
DomainZF_PHD_1

ASXL1 ASH1L KMT2D ASXL2

2.18e-03961064PS01359
DomainC2_dom

PCLO WWC2 ESYT2 CC2D2A PKN1

2.44e-031641065IPR000008
DomainGelsolin

SEC24C SEC23A

2.78e-03141062PF00626
DomainGelsolin-like_dom

SEC24C SEC23A

2.78e-03141062IPR007123
Domain-

MUC16 MUC17

3.19e-031510623.30.70.960
DomainPost-SET_dom

ASH1L KMT2D

3.64e-03161062IPR003616
DomainPostSET

ASH1L KMT2D

3.64e-03161062SM00508
DomainPOST_SET

ASH1L KMT2D

3.64e-03161062PS50868
DomainZZ

TADA2B HERC2

4.60e-03181062PF00569
DomainZF_ZZ_2

TADA2B HERC2

4.60e-03181062PS50135
DomainZF_ZZ_1

TADA2B HERC2

4.60e-03181062PS01357
DomainVWC_out

VWCE MUC2

5.12e-03191062SM00215
DomainZnf_ZZ

TADA2B HERC2

5.12e-03191062IPR000433
DomainZnF_ZZ

TADA2B HERC2

5.12e-03191062SM00291
PathwayREACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS

MUC15 MUC16 MUC17 MUC2

5.35e-0621804MM15706
PathwayREACTOME_DEFECTIVE_GALNT3_CAUSES_HFTC

MUC15 MUC16 MUC17

9.34e-0516803M27410
PathwayREACTOME_DEFECTIVE_C1GALT1C1_CAUSES_TNPS

MUC15 MUC16 MUC17

1.13e-0417803M27412
PathwayREACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS

MUC15 MUC16 MUC17

2.87e-0423803M556
PathwayREACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS

MUC15 MUC16 MUC17 MUC2

3.68e-0460804MM15636
PathwayREACTOME_DECTIN_2_FAMILY

MUC15 MUC16 MUC17

4.16e-0426803M27483
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

JCAD PDE3B MAP1B IQSEC2 MLXIP TESK1 CEP350 WWC2 ESYT2 DCP1B ZBTB21 MAP3K10 PKP2 GIGYF2 EIF4G3 GARRE1

1.80e-088611121636931259
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

DCAF6 PDE3B MAP1B ASH1L HECTD4 ZNF362 AHDC1 TASOR2 BICD1 HIVEP3 ESYT2 ZNF544 EEPD1 PKN1 ATP11A SEMA6A ELK4 EIF4G3 CLEC16A NOTCH3

5.72e-0814891122028611215
Pubmed

Mucin gene expression in human laryngeal epithelia: effect of laryngopharyngeal reflux.

MUC15 MUC16 MUC17 MUC2

3.01e-0718112418834073
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

BICD2 JCAD DCAF6 ATP13A1 IQSEC2 ASH1L HECTD4 SKIL BICD1 CEP350 SERPINE2 HPS4 MAP3K10 ANKRD36 HERC2 EIF4G3 SLX4

7.85e-0712851121735914814
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ZXDC HSPG2 SZT2 ATP13A1 HECTD4 MLXIP TESK1 AHDC1 HIVEP3 KMT2D KCNH2 ZFYVE26 PKN1 NUP188 HERC2

2.73e-0611051121535748872
Pubmed

Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development.

MAP1B DMXL1 CEP350 HERC2 SEC23A

4.87e-0676112527542412
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

BICD2 ASXL1 MLXIP SNX19 KIAA0319 SEC24C GIGYF2 ASXL2 CLEC16A

7.16e-06407112912693553
Pubmed

Co-expression of mesothelin and CA125 correlates with unfavorable patient outcome in pancreatic ductal adenocarcinoma.

MUC16 MSLN

1.03e-052112221775916
Pubmed

ASXL1/2 mutations and myeloid malignancies.

ASXL1 ASXL2

1.03e-052112236068610
Pubmed

Difference in mesothelin-binding ability of serum CA125 between patients with endometriosis and epithelial ovarian cancer.

MUC16 MSLN

1.03e-052112225197000
Pubmed

Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors.

MUC16 MSLN

1.03e-052112217067392
Pubmed

A new class of endoplasmic reticulum export signal PhiXPhiXPhi for transmembrane proteins and its selective interaction with Sec24C.

SEC24C SEC23A

1.03e-052112223658022
Pubmed

A binding domain on mesothelin for CA125/MUC16.

MUC16 MSLN

1.03e-052112219075018
Pubmed

Does CA125 binding to mesothelin impact the detection of malignant mesothelioma?

MUC16 MSLN

1.03e-052112223357461
Pubmed

Co-Expression of Mesothelin and CA125 Is Associated with the Poor Prognosis of Endometrial Serous Carcinoma and Mixed Carcinomas Including Serous Carcinoma.

MUC16 MSLN

1.03e-052112232468249
Pubmed

Significance of mesothelin and CA125 expression in endometrial carcinoma: a retrospective analysis.

MUC16 MSLN

1.03e-052112233832498
Pubmed

Notch signaling modulates MUC16 biosynthesis in an in vitro model of human corneal and conjunctival epithelial cell differentiation.

MUC16 NOTCH3

1.03e-052112221508102
Pubmed

ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia.

ASXL1 ASXL2

1.03e-052112228516957
Pubmed

Study of mucin turnover in the small intestine by in vivo labeling.

MUC17 MUC2

1.03e-052112229636525
Pubmed

Regulation of a COPII component by cytosolic O-glycosylation during mitosis.

SEC24C SEC23A

1.03e-052112215013749
Pubmed

Neuronal Roles of the Bicaudal D Family of Motor Adaptors.

BICD2 BICD1

1.03e-052112228215293
Pubmed

Coexpression of MUC16 and mesothelin is related to the invasion process in pancreatic ductal adenocarcinoma.

MUC16 MSLN

1.03e-052112222320398
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

BICD2 JCAD MAP1B ATP13A1 PCLO IQSEC2 NACA KCNB2 ESYT2 SERPINE2 MAP3K10 EIF4G3 CLEC16A MTDH

1.83e-0511391121436417873
Pubmed

Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

BICD2 HECTD4 POM121 GIGYF2 SLC24A1

2.06e-0510211259734811
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

BICD2 ASXL1 ZBTB2 MAP1B FBXO3 DCP1B TADA2B GIGYF2 ASXL2 NUP188 HERC2 EIF4G3 MTDH

2.20e-0510051121319615732
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

KIAA0319 ZFYVE26 HERC2 CLEC16A GARRE1

2.26e-0510411259205841
Pubmed

Additional sex comb-like (ASXL) proteins 1 and 2 play opposite roles in adipogenesis via reciprocal regulation of peroxisome proliferator-activated receptor {gamma}.

ASXL1 ASXL2

3.08e-053112221047783
Pubmed

Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion.

MUC16 MSLN

3.08e-053112214676194
Pubmed

Reconstitution of the targeting of Rab6A to the Golgi apparatus in semi-intact HeLa cells: A role of BICD2 in stabilizing Rab6A on Golgi membranes and a concerted role of Rab6A/BICD2 interactions in Golgi-to-ER retrograde transport.

BICD2 BICD1

3.08e-053112225962623
Pubmed

Characterization of Asxl1, a murine homolog of Additional sex combs, and analysis of the Asx-like gene family.

ASXL1 ASXL2

3.08e-053112216412590
Pubmed

Two atypical enteropathogenic Escherichia coli strains induce the production of secreted and membrane-bound mucins to benefit their own growth at the apical surface of human mucin-secreting intestinal HT29-MTX cells.

MUC17 MUC2

3.08e-053112220065027
Pubmed

Functional proteomics of the epigenetic regulators ASXL1, ASXL2 and ASXL3: a convergence of proteomics and epigenetics for translational medicine.

ASXL1 ASXL2

3.08e-053112225835095
Pubmed

ASXL2 mutations are frequently found in pediatric AML patients with t(8;21)/ RUNX1-RUNX1T1 and associated with a better prognosis.

ASXL1 ASXL2

3.08e-053112228063196
Pubmed

Familial and Somatic BAP1 Mutations Inactivate ASXL1/2-Mediated Allosteric Regulation of BAP1 Deubiquitinase by Targeting Multiple Independent Domains.

ASXL1 ASXL2

3.08e-053112229284740
Pubmed

Free CA125 promotes ovarian cancer cell migration and tumor metastasis by binding Mesothelin to reduce DKK1 expression and activate the SGK3/FOXO3 pathway.

MUC16 MSLN

3.08e-053112233613114
Pubmed

Kinetic Characterization of ASXL1/2-Mediated Allosteric Regulation of the BAP1 Deubiquitinase.

ASXL1 ASXL2

3.08e-053112233731362
Pubmed

Understanding the phenotypic spectrum of ASXL-related disease: Ten cases and a review of the literature.

ASXL1 ASXL2

3.08e-053112233751773
Pubmed

Characteristics of rodent intestinal mucin Muc3 and alterations in a mouse model of human cystic fibrosis.

MUC17 MUC2

3.08e-053112211352827
Pubmed

Prevalence of arrhythmia-associated gene mutations and risk of sudden cardiac death in the Finnish population.

KCNH2 PKP2

3.08e-053112223651034
Pubmed

JARID1A, JMY, and PTGER4 polymorphisms are related to ankylosing spondylitis in Chinese Han patients: a case-control study.

PTGER4 JMY

3.08e-053112224069348
Pubmed

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.

ASXL1 KMT2D ASXL2

3.56e-0520112329785026
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

MUC16 DMXL1 TASOR2 CEP350 SEC24C PKP2 PKN1 EIF4G3 CLEC16A MTDH SEC23A

4.37e-057771121135844135
Pubmed

Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.

IQSEC2 NACA KCNB2 EVI5 SERPINE2 MAP3K10

4.45e-05197112636604605
Pubmed

Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis.

MUC16 MSLN

6.14e-054112234253615
Pubmed

Structural basis for cargo regulation of COPII coat assembly.

SEC24C SEC23A

6.14e-054112218692470
Pubmed

Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex.

BICD2 BICD1

6.14e-054112212447383
Pubmed

cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites.

SEC24C SEC23A

6.14e-054112221525241
Pubmed

BAP1/ASXL complex modulation regulates epithelial-mesenchymal transition during trophoblast differentiation and invasion.

ASXL1 ASXL2

6.14e-054112234170818
Pubmed

Notch3 and Jagged2 contribute to gastric cancer development and to glandular differentiation associated with MUC2 and MUC5AC expression.

MUC2 NOTCH3

6.14e-054112222691042
Pubmed

TANGO1 facilitates cargo loading at endoplasmic reticulum exit sites.

SEC24C SEC23A

6.14e-054112219269366
Pubmed

Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans.

PTTG1 TCERG1L

6.14e-054112222791750
Pubmed

Tumor suppressor microRNA-27a in colorectal carcinogenesis and progression by targeting SGPP1 and Smad2.

SGPP1 MUC2

6.14e-054112225166914
Pubmed

Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro.

SEC24C SEC23A

6.14e-054112215899885
Pubmed

Structural basis of semaphorin-plexin signalling.

SEMA6A PLXNB1

6.14e-054112220877282
Pubmed

PGE(2) induces MUC2 and MUC5AC expression in human intrahepatic biliary epithelial cells via EP4/p38MAPK activation.

PTGER4 MUC2

6.14e-054112223619266
Pubmed

Butyrate enemas upregulate Muc genes expression but decrease adherent mucus thickness in mice colon.

MUC17 MUC2

6.14e-054112218198997
Pubmed

Oncogenic Truncations of ASXL1 Enhance a Motif for BRD4 ET-Domain Binding.

ASXL1 ASXL2

6.14e-054112234536441
Pubmed

Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.

BICD2 SKIL BICD1

7.10e-0525112312522145
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

SZT2 MUC16 ZNF362 MLXIP KMT2D HERC2 EIF4G3 MUC2 GARRE1

7.74e-05552112910737800
Pubmed

Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord.

MLXIP KIAA0319 SEC24C

8.99e-0527112319026994
Pubmed

Multifaceted transcriptional regulation of the murine intestinal mucus layer by endogenous microbiota.

MUC17 MUC2

1.02e-045112218035521
Pubmed

Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis.

MUC16 MSLN

1.02e-045112228287406
Pubmed

Transposon mutagenesis identifies genetic drivers of Braf(V600E) melanoma.

CEP350 IL2RG

1.02e-045112225848750
Pubmed

ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation.

HSPG2 PKP2 NOTCH3

1.37e-0431112322274697
Pubmed

Mammalian Sec16/p250 plays a role in membrane traffic from the endoplasmic reticulum.

SEC24C SEC23A

1.53e-046112217428803
Pubmed

Sec24 proteins and sorting at the endoplasmic reticulum.

SEC24C SEC23A

1.53e-046112210075675
Pubmed

Expression of Muc19/Smgc gene products during murine sublingual gland development: cytodifferentiation and maturation of salivary mucous cells.

MUC16 MUC2

1.53e-046112219110483
Pubmed

A family of mammalian proteins homologous to yeast Sec24p.

SEC24C SEC23A

1.53e-046112210329445
Pubmed

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair.

BICD2 BICD1 NUP188 SLX4

1.69e-0485112419596235
Pubmed

p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.

BICD1 CEP350 SERPINE2 SCO1 MTDH

1.70e-04159112530581152
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ZBTB2 ATP13A1 CEP350 HIVEP3 POM121 EEPD1 ATP11A SLX4

2.02e-04493112815368895
Pubmed

Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity.

SEC24C SEC23A

2.14e-047112217452640
Pubmed

The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes.

BICD2 BICD1

2.14e-047112212401177
Pubmed

Assay and properties of rab6 interaction with dynein-dynactin complexes.

BICD2 BICD1

2.14e-047112216473624
Pubmed

Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.

PDE3B ATP13A1 ESYT2 PKP2 GIGYF2 SEMA6A MTDH

2.20e-04375112732788342
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

ZNF362 SKIL AHDC1 KMT2D TADA2B ZBTB21

2.39e-04268112633640491
Pubmed

A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles.

PTTG1 PTGER4 CLEC16A

2.73e-0439112320962850
Pubmed

The mutational landscape of lethal castration-resistant prostate cancer.

ASXL1 KMT2D

2.84e-048112222722839
Pubmed

Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.

ASH1L KMT2D

2.84e-048112223130995
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SZT2 NACA HECTD4 HPS4 ZBTB21 NUP188 GARRE1 PLXNB1

3.24e-04529112814621295
Pubmed

The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer.

ASXL1 ASXL2

3.65e-049112226416890
Pubmed

Additional sex combs-like family genes are required for normal cardiovascular development.

ASXL1 ASXL2

3.65e-049112224860998
Pubmed

GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome.

BICD2 BICD1

3.65e-049112217139249
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

MAP1B IQSEC2 ASH1L ZNF362 CEP350 ESYT2 TADA2B ZBTB21 ASXL2

4.00e-04689112936543142
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

BICD2 JCAD MLXIP BICD1 CEP350 ESYT2 GIGYF2 HERC2 CLEC16A GARRE1

4.45e-048531121028718761
Pubmed

The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope.

SEC24C SEC23A

4.55e-0410112217499046
Pubmed

Dynein and kinesin regulate stress-granule and P-body dynamics.

BICD2 BICD1

4.55e-0410112219825938
Pubmed

ASXL3 bridges BRD4 to BAP1 complex and governs enhancer activity in small cell lung cancer.

ASXL1 ASXL2

4.55e-0410112232669118
Pubmed

Structural basis of cargo membrane protein discrimination by the human COPII coat machinery.

SEC24C SEC23A

4.55e-0410112218843296
Pubmed

The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1.

ASXL1 ASXL2

4.55e-0410112219815555
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

MAP1B NACA CEP350 POM121 SEC24C ZBTB21 GIGYF2 NUP188 HERC2 MTDH SEC23A

4.79e-0410241121124711643
Pubmed

USP7 Regulates Cytokinesis through FBXO38 and KIF20B.

ZXDC ZNF362 TADA2B ZBTB21

5.53e-04116112430804394
Pubmed

Identification of proteins that interact with alpha A-crystallin using a human proteome microarray.

WWC2 SEC24C EEPD1 GIGYF2

5.90e-04118112424453475
Pubmed

A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.

MAP1B SEC24C EIF4G3 SEC23A

5.90e-04118112430979931
Pubmed

Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.

ZXDC HSPG2 PKN1 MTDH NOTCH3

6.62e-04214112522199357
Pubmed

De novo genic mutations among a Chinese autism spectrum disorder cohort.

HIVEP3 GIGYF2

6.64e-0412112227824329
Pubmed

Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina.

SEMA6A PLXNB1

6.64e-0412112221270798
Pubmed

Functional proteomics mapping of a human signaling pathway.

HSPG2 ASH1L SKIL KMT2D DCP1B PKP2 ASXL2 HERC2

6.72e-04591112815231748
Pubmed

Human transcription factor protein interaction networks.

HSPG2 ASXL1 NACA KMT2D DCP1B TADA2B ZBTB21 GIGYF2 ASXL2 ELK4 HERC2 GARRE1 SLX4

7.02e-0414291121335140242
Pubmed

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

ASXL1 PCDHA7 KCNB2 SLC24A1 IL2RG NOTCH3

7.07e-04329112617474147
InteractionYWHAH interactions

JCAD PDE3B IQSEC2 HECTD4 MLXIP TESK1 CEP350 WWC2 ESYT2 DCP1B KCNH2 ZBTB21 MAP3K10 PKP2 CC2D2A GIGYF2 EIF4G3 CLEC16A GARRE1

6.57e-06110210919int:YWHAH
Cytoband9q21.32

SPATA31D4 SPATA31D1 SPATA31D3

1.33e-051911239q21.32
GeneFamilyCD molecules|Mucins

MUC15 MUC16 MUC17 MUC2

1.24e-0621714648
CoexpressionGSE32986_GMCSF_VS_GMCSF_AND_CURDLAN_HIGHDOSE_STIM_DC_DN

KANSL1L HECTD4 PTGER4 DMXL1 EVI5 HPS4 ZFYVE26 ASXL2

1.95e-061981108M8624
ToppCellTCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-5|TCGA-Ovary / Sample_Type by Project: Shred V9

ZXDC KANSL1L DCAF6 SZT2 HECTD4 GIGYF2 PLXNB1

2.14e-07166112732d2eaf8a5d03881bf74d680825af2d5110b082d
ToppCell(08)_PNEC|World / shred by cell type and Timepoint

TCERG1L MAP1B PCLO KCNB2 TEKT5 SERPINE2 KCNH2

6.58e-0719611272ee37155c03cd5009427a4bffe6c80ed2ac6939e
ToppCelldroplet-Heart-nan-3m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JCAD COL28A1 EEPD1 SEMA6A ELK4 GARRE1

6.77e-06182112681279877b920b5a1bc991a07d3031d6458700fe3
DrugTolnaftate [2398-96-1]; Down 200; 13uM; MCF7; HT_HG-U133A

HSPG2 IQSEC2 SKIL AHDC1 BICD1 HIVEP3 EVI5 HPS4

5.09e-0619810984805_DN
DrugSotalol hydrochloride [959-24-0]; Down 200; 13uM; MCF7; HT_HG-U133A

PRR36 SZT2 ASH1L AHDC1 BICD1 KCNH2 HPS4 ATP11A

5.29e-0619910987338_DN
DrugTrimeprazine tartrate [4330-99-8]; Up 200; 5.4uM; MCF7; HT_HG-U133A

PDE3B SPAG4 PRR36 HIVEP3 YIPF2 NUP188 PLXNB1

4.33e-0519510973478_UP
DrugThiamphenicol [15318-45-3]; Down 200; 11.2uM; HL60; HT_HG-U133A

KANSL1L PDE3B TESK1 AHDC1 SNX19 BICD1 FBXO3

4.33e-0519510971867_DN
DrugSB 202190; Up 200; 1uM; MCF7; HT_HG-U133A

HSPG2 MAP1B BICD1 SERPINE2 KCNH2 CES3 SLC24A1

4.47e-0519610976887_UP
DrugSpiramycin [8025-81-8]; Up 200; 4.8uM; PC3; HT_HG-U133A

SZT2 IQSEC2 MLXIP SGPP1 ATP11A DMBT1 CLEC16A

4.47e-0519610974319_UP
DrugRibostamycin sulfate salt [53797-35-6]; Down 200; 7.2uM; PC3; HT_HG-U133A

JCAD SH2D3A TESK1 SNX19 BICD1 WWC2 HPS4

4.47e-0519610977123_DN
DrugAcyclovir [59277-89-3]; Down 200; 17.8uM; MCF7; HT_HG-U133A

KANSL1L PDE3B PRR36 POM121L2 EVI5 ATP11A SLC24A1

4.62e-0519710975643_DN
DrugLithocholic acid [434-13-9]; Up 200; 10.6uM; MCF7; HT_HG-U133A

PRR36 ZNF362 KCNH2 ATP11A NUP188 MUC2 IL2RG

4.62e-0519710973899_UP
DrugCarbimazole [22232-54-8]; Up 200; 21.4uM; MCF7; HT_HG-U133A

PDE3B POM121L2 TESK1 WWC2 NUP188 SLC24A1 GARRE1

4.77e-0519810975399_UP
DrugAtropine-N-oxide hydrochloride [4574-60-1]; Up 200; 11.8uM; MCF7; HT_HG-U133A

KANSL1L JCAD HSPG2 HIVEP3 ATP11A DMBT1 SLC24A1

4.77e-0519810976812_UP
DrugAtracurium besylate [64228-81-5]; Down 200; 3.2uM; MCF7; HT_HG-U133A

KANSL1L ASH1L EVI5 ZFYVE26 ATP11A PLXNB1 NOTCH3

4.92e-0519910971702_DN
DrugEburnamonine (-) [4880-88-0]; Down 200; 13.6uM; MCF7; HT_HG-U133A

KANSL1L PDE3B NACA ASH1L SKIL KCNH2 ELK4

4.92e-0519910972781_DN
DrugLoxapine succinate [27833-64-3]; Up 200; 9uM; HL60; HG-U133A

SKIL SNX19 DMXL1 HIVEP3 EVI5 YIPF2 SEC23A

5.08e-0520010972016_UP
Diseasespinal muscular atrophy with lower extremity predominant 2A (implicated_via_orthology)

BICD2 BICD1

1.25e-0521052DOID:0070349 (implicated_via_orthology)
DiseaseNeurodevelopmental Disorders

IQSEC2 ASH1L HIVEP3 GIGYF2 PLXNB1

2.10e-05931055C1535926
Diseaseseasonality measurement, vitamin D measurement

PDE3B SEC23A

1.25e-0451052EFO_0004631, EFO_0006876
Diseaserenal overload-type gout

SPATA31C2 SPATA31C1

1.86e-0461052EFO_0021525
Diseasegrapefruit juice consumption measurement

PCLO DCP1B

2.60e-0471052EFO_0010094
Diseaseeosinophil cationic protein measurement

SPATA31C2 SPATA31C1

3.46e-0481052EFO_0010913
Diseaselongitudinal alcohol consumption measurement

SPATA31C2 SPATA31C1

4.44e-0491052EFO_0007645
Diseasethyroid gland papillary carcinoma (is_implicated_in)

MINPP1 KMT2D

5.54e-04101052DOID:3969 (is_implicated_in)
Diseasecancer antigen 125 measurement

MUC16 MSLN

5.54e-04101052EFO_0010603
Diseaseautosomal dominant nonsyndromic deafness (is_implicated_in)

MAP1B ATP11A

6.76e-04111052DOID:0050564 (is_implicated_in)
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

ASH1L GIGYF2 PLXNB1

7.16e-04491053DOID:0060037 (implicated_via_orthology)
Diseaseegg allergy measurement, parental genotype effect measurement

SPATA31C2 SPATA31C1

9.54e-04131052EFO_0005939, EFO_0007018
Diseasepursuit maintenance gain measurement

ZXDC SPATA31C2 MINPP1 SPATA31C1

9.93e-041231054EFO_0008433
Diseaseamygdala volume change measurement

SPATA31C2 SPATA31C1

1.46e-03161052EFO_0021490
Diseasepancreatitis

JCAD HECTD4

1.46e-03161052EFO_0000278
Diseasecholangiocarcinoma (is_marker_for)

WNT9A MUC16 MUC2

1.56e-03641053DOID:4947 (is_marker_for)
DiseaseParoxysmal atrial fibrillation

HSPG2 NACA KCNH2 PKP2

2.38e-031561054C0235480
Diseasefamilial atrial fibrillation

HSPG2 NACA KCNH2 PKP2

2.38e-031561054C3468561
DiseasePersistent atrial fibrillation

HSPG2 NACA KCNH2 PKP2

2.38e-031561054C2585653
Diseasereaction time measurement

BICD2 ATP13A1 HECTD4 KMT2D POM121 CC2D2A GIGYF2 EIF4G3

2.46e-036581058EFO_0008393
DiseaseAtrial Fibrillation

HSPG2 NACA KCNH2 PKP2

2.60e-031601054C0004238
Diseaseobsolete Mendelian syndromes with cleft lip/palate

JCAD PKN1

3.02e-03231052MONDO_0015335
DiseaseCleft palate, cleft lip

MAP1B SPATA31C2 SPATA31C1 GIGYF2 MTDH

3.26e-032791055EFO_0003959, HP_0000175
Diseaseperiodontal measurement

ASH1L PKP2

3.29e-03241052EFO_0007780
DiseaseCarcinoma, Pancreatic Ductal

NOTCH3 MSLN

3.29e-03241052C0887833
DiseaseBrugada Syndrome (disorder)

KCNH2 PKP2

3.29e-03241052C1142166
Diseasepancreatic carcinoma

NACA BICD1 PKN1 DMBT1

3.52e-031741054EFO_0002618

Protein segments in the cluster

PeptideGeneStartEntry
EPTPSIASDISLPIA

ESYT2

751

A0FGR8
TPELVPSDVPLTTTD

BPIFB3

301

P59826
PLAVSLTSQSLIPPL

AGPAT4-IT1

116

Q9H0P7
PLLPSSASSSEILPS

ASH1L

1091

Q9NR48
PSEPESTLQPVLSLI

ASH1L

1961

Q9NR48
APPSPSLVSDLLSEL

BICD2

326

Q8TD16
LRVPPDPTSTESFLL

BICD1

881

Q96G01
SLTLPTRLIETTPAP

ADGRG4

506

Q8IZF6
TSVVPPELPIELSLA

ATP13A1

486

Q9HD20
GILPSLPLLSSSIPE

BNC1

506

Q01954
PPLSTLTLKEADPSS

ANKRD36

516

A6QL64
STLPTVPSSPDLEVS

DCAF6

381

Q58WW2
PLLSDLTLSPVPRDS

AHDC1

1541

Q5TGY3
ATDIPLLPSITSLSL

DMXL1

366

Q9Y485
PTSLSLQSEDLDLPP

EEPD1

221

Q7L9B9
LSEPLEPSSLPSQLS

ASXL1

1421

Q8IXJ9
PELFSSTVLPLPADS

ASXL2

1286

Q76L83
SLLVETTSLPPRPET

HSPG2

246

P98160
TLTSLSLPIPEDAQP

PCDHA7

351

Q9UN72
TLVPLDTPSPATSLE

MUC16

1216

Q8WXI7
ESIPSSPLPVTALLT

MUC16

5651

Q8WXI7
PDISTEVIPSLPISL

MUC16

6711

Q8WXI7
SSPSLENPSSLPSLL

MUC16

7086

Q8WXI7
ENPSSLPSLLSLPAT

MUC16

7091

Q8WXI7
PVTISSSPLPVTSLL

MUC16

7116

Q8WXI7
PESISSSPLPVTSLL

MUC16

7991

Q8WXI7
LLDSSPSSPLPVTSL

MUC16

9746

Q8WXI7
TTIPILTLSPGEPET

MUC16

10891

Q8WXI7
TTLPTLTLSPGEPET

MUC16

11001

Q8WXI7
LTLTPSILTLDSLTP

PLAC4

106

Q8WY50
SLIAPLNLSPTSSPL

KANSL1L

486

A0AUZ9
TPSPSTNPLVDLELE

MAP3K10

786

Q02779
KSDISPLTPRESSPL

MAP1B

1781

P46821
SPSTLQVLPDSESLP

MAGEA10

116

P43363
LPLSGVTSELPPTIS

JMY

771

Q8N9B5
VTSELPPTISLPLLN

JMY

776

Q8N9B5
LSSEPTSPSVTPLIV

MUC15

171

Q8N387
TPSPSLTTALLPEEL

SLC24A1

406

O60721
LTTALLPEELSPSPS

SLC24A1

411

O60721
SPSVELLAEILPPSA

FSCB

341

Q5H9T9
LLAEILPPSAEESPS

FSCB

346

Q5H9T9
TIPDLGSLSSPLIDT

HERC2

1291

O95714
LPLLTIEPPSDSSVD

IQSEC2

591

Q5JU85
LSPESLSCTEIPIPL

JCAD

236

Q9P266
SLEPTPPEDTAISSL

HPS4

411

Q9NQG7
PVSPLPTLTLDSLSQ

KCNH2

1096

Q12809
TETAPLTLESLPTDP

FBXO3

6

Q9UK99
LSSISITIPPEPLAL

PCLO

2691

Q9Y6V0
SATPEDLLASPLSPS

PLXNB1

781

O43157
LTESTTLLSTLPPAI

MUC2

4231

Q02817
LLTDPSLPPQVISSL

PDE3B

366

Q13370
TSQTLLPDLSLPDLS

PTGER4

391

P35408
SPSSPSQLSPDDLEL

EVI5

71

O60447
SVTLSPVDSLDSPRP

NOTCH3

2096

Q9UM47
ALPTESSTPLSAIIP

SERPINE2

256

P07093
SLSPEELSSVPPSSI

MSLN

451

Q13421
PPLPDGTISSSSILL

HECTD4

2491

Q9Y4D8
PTSLLAPSTNPLLES

POM121

586

Q96HA1
SILPTTALPTVSLPD

MLXIP

366

Q9HAP2
TALPTVSLPDSLIAP

MLXIP

371

Q9HAP2
LLPIQSPEPSVITSS

DCP1B

561

Q8IZD4
STLSLPPEPVDIIRS

KCNB2

16

Q92953
SPTLLAEVFLPIPET

CC2D2A

736

Q9P2K1
EATTTPRPLLSTPVD

COL28A1

1051

Q2UY09
PLSQIPSDTASPLLI

GIGYF2

436

Q6Y7W6
ETLVSPKLPSLEAPT

ELK4

226

P28324
ELAPTLVITSSDPSP

ELK4

326

P28324
ISASLVPPSLDPSLT

POLQ

1926

O75417
TSTLPSPPLLTTVED

GARRE1

951

O15063
PTDLETRSPSPISIS

CEP350

1821

Q5VT06
PTDSLSVSTLPLPEV

IL2RG

46

P31785
TLPPATSTEPSVILS

MTDH

511

Q86UE4
LAISTPVLTSLDVPP

CES3

371

Q6UWW8
RPDTLSTITLPPSTV

DMBT1

711

Q9UGM3
SPDTLPTITLPASTV

DMBT1

971

Q9UGM3
LLPLTKSPVESTTEP

SEC24C

951

P53992
TTLPDLTPLFISIDP

SCO1

191

O75880
IPIPSLTSCTETSDP

EIF4G3

311

O43432
SPSSILSTLDVELPP

PTTG1

181

O95997
PSEGSPLLTSIPVSI

MUC17

801

Q685J3
SPLLTSIPLSTTPVA

MUC17

2101

Q685J3
LTLPLEVELPTASDP

SZT2

1621

Q5T011
PPDTASATVSTPILI

RNF183

131

Q96D59
SLSASQPPEPSLLLE

SPATA31C2

186

B4DYI2
PGPLLIPSDSSTELT

SKIL

131

P12757
SLTTPLPPLDISVAE

TADA2B

146

Q86TJ2
LATLPLQASPSPLTT

PRR36

526

Q9H6K5
SPLTTVSLQDPPLVS

PRR36

536

Q9H6K5
SLDTLPLAGPPITVT

SGPP1

346

Q9BX95
DESTSTLRPPTILPT

TEKT5

66

Q96M29
TTPEDLILSSRPKPS

SPATA31D4

176

Q6ZUB0
PSEDVPSAPLLLTLD

MYBPH

66

Q13203
SLSSPIQESTAPELP

PKN1

576

Q16512
SSLSASQPPEPSLLL

SPATA31C1

191

P0DKV0
LSTPDSSVVPALTPE

SSC5D

1071

A1L4H1
STSQIPTLEPSPALE

SSC5D

1376

A1L4H1
ASDLTVSPDPLLSPT

SSC5D

1431

A1L4H1
SPVVSEEPLDLLPTL

SPAG4

106

Q9NPE6
ILLTPTSPTLPVTDT

POM121L2

466

Q96KW2
PPEPVLLDSSSILAD

SEC23A

631

Q15436
LSEEVELSSTPPLPA

SLX4

491

Q8IY92
TLSVESLTLVPPVDP

CLEC16A

1001

Q2KHT3
IIDTPTSPVTSGLPL

ATP11A

86

P98196
SPSLGLPPSSTVELV

TCERG1L

121

Q5VWI1
TTPEDLILSSRPKPS

SPATA31D3

176

P0C874
TEPSSPLSDPSDIIR

ZBTB21

431

Q9ULJ3
DLLPQLEAPSSLTPS

ZXDC

481

Q2QGD7
SLSSLSPPGSPLVLE

WWC2

551

Q6AWC2
SLLEPRDPVASSLSP

MINPP1

31

Q9UNW1
PISALPRTSSDPVLL

SH2D3A

171

Q9BRG2
TLASTPSATPPEDLI

SPATA31D1

171

Q6ZQQ2
DLTALPTPESTPTLQ

SEMA6A

751

Q9H2E6
STQPLLPLSTEDKPS

HIVEP3

436

Q5T1R4
LPLSTEDKPSLVPLS

HIVEP3

441

Q5T1R4
LLSTLLATPVPTASL

VWCE

336

Q96DN2
LSPPSETSEPSILET

NUP188

1021

Q5SRE5
TISTLLSSDEPSPPA

SLC12A3

21

P55017
FPSTQLPLVTTPETL

TESK1

411

Q15569
VSSLDPTLPPVLLSS

SNX19

491

Q92543
ALPTCSLLTSSPPLE

ZNF252P-AS1

101

Q0IIN9
SEPLTILPLTLEPEA

WNT9A

36

O14904
SLPSTLSLLPTTLPT

ZNF544

166

Q6NX49
PTLISGITSPPLLDS

ZNF362

161

Q5T0B9
DPLQTSLSPELVSTP

ZBTB2

196

Q8N680
DIDLALTISPPTSPR

TASOR2

1281

Q5VWN6
ITSLPSNIALSPTLP

YIPF2

296

Q9BWQ6
DDLPLSTPSSPRTTE

ZFYVE26

1266

Q68DK2
LPDLVSIIPDTVPST

PKP2

771

Q99959
TPSTLPEEATGLLTP

TIMD4

201

Q96H15
SPDSIVPASSPESIL

KMT2D

4701

O14686
ERSVLLPLPTTPSSG

KIAA0319

231

Q5VV43
TSSSPEIPLSPEATL

NACA

576

E9PAV3
DILLDLDSPAPVTTP

NECAP1

226

Q8NC96