Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	cranial skeletal system development	IRF6 FGFR2 MMP14 FOXC2	1.89e-05	84	39	4	GO:1904888
GeneOntologyBiologicalProcess	outflow tract morphogenesis	ROBO1 FGFR2 RYR1 FOXC2	2.94e-05	94	39	4	GO:0003151
GeneOntologyBiologicalProcess	skin development	FLNB IRF6 FGFR2 FOXI3 SCD RYR1	6.62e-05	373	39	6	GO:0043588
GeneOntologyBiologicalProcess	embryonic cranial skeleton morphogenesis	FGFR2 MMP14 FOXC2	1.30e-04	52	39	3	GO:0048701
GeneOntologyBiologicalProcess	muscle organ development	FLNB FGFR2 MYLK P2RX2 RYR1 FOXC2	1.56e-04	436	39	6	GO:0007517
MousePheno	absent presphenoid bone	IRF6 FGFR2 FOXC2	3.37e-06	13	33	3	MP:0004449
MousePheno	abnormal palatine bone morphology	IRF6 FGFR2 FOXI3 FOXC2	3.92e-06	46	33	4	MP:0005249
MousePheno	abnormal cranial cartilage morphology	FGFR2 FOXI3 MMP14 FOXC2	5.49e-06	50	33	4	MP:0030464
MousePheno	abnormal viscerocranium morphology	CDKN1B ROBO1 FLNB IRF6 FGFR2 FOXI3 MMP14 RBBP7 FOXC2	6.47e-06	593	33	9	MP:0005274
MousePheno	abnormal orbit morphology	FGFR2 MMP14 FOXC2	9.55e-06	18	33	3	MP:0010030
MousePheno	delayed bone ossification	FLNB IRF6 FGFR2 MMP14 RYR1	1.11e-05	127	33	5	MP:0000060
MousePheno	abnormal cranium morphology	CDKN1B ROBO1 FLNB IRF6 FGFR2 FOXI3 MMP14 RBBP7 RYR1 FOXC2	1.14e-05	813	33	10	MP:0000438
MousePheno	abnormal craniofacial bone morphology	CDKN1B ROBO1 FLNB IRF6 FGFR2 FOXI3 MMP14 RBBP7 RYR1 FOXC2	1.32e-05	827	33	10	MP:0002116
MousePheno	abnormal mouth morphology	CDKN1B ROBO1 IRF6 FGFR2 FOXI3 MMP14 RBBP7 RYR1 FOXC2	1.73e-05	670	33	9	MP:0000452
MousePheno	abnormal jaw morphology	CDKN1B ROBO1 IRF6 FGFR2 FOXI3 MMP14 RBBP7 FOXC2	2.43e-05	530	33	8	MP:0000454
MousePheno	abnormal bone ossification	FLNB IRF6 FGFR2 COL12A1 MMP14 RYR1 FOXC2	3.09e-05	395	33	7	MP:0008271
MousePheno	perinatal lethality	ROBO1 FLNB IRF6 FGFR2 COL12A1 RUNX1T1 FOXI3 SCD RYR1 GABRA1 FOXC2	3.36e-05	1130	33	11	MP:0002081
MousePheno	abnormal neurocranium morphology	FLNB IRF6 FGFR2 FOXI3 MMP14 FOXC2	3.44e-05	269	33	6	MP:0000074
MousePheno	thick epidermis	PBK IRF6 FGFR2 SCD	3.59e-05	80	33	4	MP:0001219
MousePheno	abnormal palatine bone horizontal plate morphology	IRF6 FGFR2 FOXC2	3.77e-05	28	33	3	MP:0004537
MousePheno	decreased renal glomerulus number	FGFR2 MMP14 FOXC2	4.66e-05	30	33	3	MP:0004505
MousePheno	cleft palate	ROBO1 IRF6 FGFR2 FOXI3 RYR1 FOXC2	5.13e-05	289	33	6	MP:0000111
MousePheno	oral cleft	ROBO1 IRF6 FGFR2 FOXI3 RYR1 FOXC2	5.33e-05	291	33	6	MP:0021164
MousePheno	abnormal presphenoid bone morphology	IRF6 FGFR2 FOXC2	6.23e-05	33	33	3	MP:0004448
MousePheno	abnormal forelimb morphology	FLNB IRF6 FGFR2 SNAPC4 MMP14	6.25e-05	182	33	5	MP:0000550
MousePheno	abnormal sphenoid bone morphology	IRF6 FGFR2 FOXI3 FOXC2	7.04e-05	95	33	4	MP:0000104
MousePheno	absent incus	FOXI3 FOXC2	8.06e-05	6	33	2	MP:0004318
MousePheno	abnormal bronchiole morphology	ROBO1 FGFR2 MMP14	8.82e-05	37	33	3	MP:0002267
MousePheno	abnormal palate morphology	ROBO1 IRF6 FGFR2 FOXI3 RYR1 FOXC2	9.18e-05	321	33	6	MP:0003755
MousePheno	abnormal ear morphology	CDKN1B IRF6 FGFR2 FOXI3 MMP14 P2RX2 FOXC2	9.28e-05	470	33	7	MP:0002102
MousePheno	small pterygoid bone	FOXI3 FOXC2	1.13e-04	7	33	2	MP:0004456
MousePheno	abnormal interventricular groove morphology	FGFR2 RYR1	1.13e-04	7	33	2	MP:0004032
MousePheno	abnormal cartilage morphology	FLNB FGFR2 COL12A1 FOXI3 MMP14 FOXC2	1.18e-04	336	33	6	MP:0000163
MousePheno	abnormal Meckel's cartilage morphology	FOXI3 MMP14 FOXC2	1.20e-04	41	33	3	MP:0005587
MousePheno	decreased hair follicle number	IRF6 FGFR2 SCD	1.20e-04	41	33	3	MP:0000379
MousePheno	increased brown adipose tissue amount	CDKN1B RYR1 FOXC2	1.39e-04	43	33	3	MP:0000005
MousePheno	perinatal lethality, incomplete penetrance	ROBO1 FLNB IRF6 COL12A1 RUNX1T1 SCD GABRA1	1.42e-04	503	33	7	MP:0011090
MousePheno	decreased submandibular gland size	FGFR2 MMP14	1.50e-04	8	33	2	MP:0009520
MousePheno	decreased hippocampal commissure size	ROBO1 DRAXIN	1.50e-04	8	33	2	MP:0008222
MousePheno	palatal shelf fusion with tongue or mandible	IRF6 FGFR2	1.50e-04	8	33	2	MP:0009884
MousePheno	abnormal facial morphology	CDKN1B ROBO1 IRF6 FGFR2 FOXI3 MMP14 RBBP7 RYR1 FOXC2	1.88e-04	910	33	9	MP:0003743
MousePheno	thin ribs	FLNB RYR1	1.93e-04	9	33	2	MP:0004674
MousePheno	cleft secondary palate	IRF6 FGFR2 RYR1 FOXC2	2.17e-04	127	33	4	MP:0009890
MousePheno	abnormal palate bone morphology	IRF6 FGFR2 FOXC2	2.31e-04	51	33	3	MP:0009891
MousePheno	absent outer ear	IRF6 FOXI3	2.40e-04	10	33	2	MP:0005579
MousePheno	abnormal epidermis stratum corneum morphology	PBK IRF6 FGFR2 SCD	2.51e-04	132	33	4	MP:0001240
MousePheno	abnormal hair follicle development	FGFR2 SCD RYR1	2.74e-04	54	33	3	MP:0003704
MousePheno	short snout	ROBO1 IRF6 FGFR2 MMP14	2.82e-04	136	33	4	MP:0000445
MousePheno	absent stapes	FOXI3 FOXC2	2.93e-04	11	33	2	MP:0004204
MousePheno	curly tail	IRF6 FGFR2 SCD	3.22e-04	57	33	3	MP:0003051
MousePheno	abnormal axial skeleton morphology	CDKN1B ROBO1 FLNB IRF6 FGFR2 COL12A1 FOXI3 MMP14 RBBP7 RYR1 FOXC2	3.37e-04	1458	33	11	MP:0002114
MousePheno	small snout	ROBO1 IRF6 FGFR2 MMP14	3.50e-04	144	33	4	MP:0030190
MousePheno	abnormal maxilla morphology	FGFR2 FOXI3 MMP14 RBBP7	3.50e-04	144	33	4	MP:0000455
MousePheno	abnormal pterygoid bone morphology	FOXI3 FOXC2	3.51e-04	12	33	2	MP:0004453
MousePheno	ostium secundum atrial septal defect	ROBO1 RYR1	3.51e-04	12	33	2	MP:0010405
MousePheno	abnormal hair follicle morphology	IRF6 FGFR2 SCD RYR1	3.89e-04	148	33	4	MP:0000377
MousePheno	skin fibrosis	PBK MMP14	4.15e-04	13	33	2	MP:0009932
MousePheno	neonatal lethality	ROBO1 FLNB IRF6 FGFR2 RUNX1T1 FOXI3 SCD RYR1	4.25e-04	799	33	8	MP:0002058
MousePheno	abnormal parietal bone morphology	FLNB FGFR2 MMP14	4.53e-04	64	33	3	MP:0000109
MousePheno	abnormal epidermis stratum spinosum morphology	IRF6 FGFR2 SCD	4.74e-04	65	33	3	MP:0001236
MousePheno	abnormal ear development	FGFR2 FOXI3 FOXC2	4.74e-04	65	33	3	MP:0003938
MousePheno	tight skin	IRF6 RYR1	4.83e-04	14	33	2	MP:0001198
MousePheno	abnormal secondary palate morphology	IRF6 FGFR2 RYR1 FOXC2	5.10e-04	159	33	4	MP:0013550
MousePheno	abnormal hard palate morphology	IRF6 FGFR2 FOXC2	5.18e-04	67	33	3	MP:0003756
MousePheno	abnormal long bone epiphyseal plate proliferative zone	FLNB FGFR2 MMP14	5.41e-04	68	33	3	MP:0003662
MousePheno	translucent skin	FGFR2 RYR1	5.57e-04	15	33	2	MP:0001201
MousePheno	abnormal skeleton physiology	FLNB IRF6 FGFR2 COL12A1 MMP14 RYR1 FOXC2	5.70e-04	632	33	7	MP:0001533
MousePheno	abnormal epidermis stratum granulosum morphology	IRF6 FGFR2 SCD	5.89e-04	70	33	3	MP:0001239
MousePheno	neonatal lethality, incomplete penetrance	ROBO1 FLNB IRF6 RUNX1T1 SCD	6.19e-04	298	33	5	MP:0011088
MousePheno	split xiphoid process	IRF6 FGFR2	6.35e-04	16	33	2	MP:0004678
MousePheno	enlarged prostate gland	CDKN1B FGFR2	6.35e-04	16	33	2	MP:0004958
MousePheno	abnormal cartilage development	FLNB FGFR2 COL12A1 MMP14	6.85e-04	172	33	4	MP:0000164
MousePheno	abnormal vestibulocochlear ganglion morphology	FGFR2 FOXI3	7.19e-04	17	33	2	MP:0003703
MousePheno	abnormal skin appearance	IRF6 FGFR2 RUNX1T1 MMP14 SCD RYR1	7.40e-04	473	33	6	MP:0009931
MousePheno	abnormal mandible morphology	IRF6 FOXI3 MMP14 FOXC2	7.47e-04	176	33	4	MP:0000458
MousePheno	abnormal adrenal medulla morphology	CDKN1B CHGB	8.08e-04	18	33	2	MP:0008289
MousePheno	absent middle ear ossicles	FOXI3 FOXC2	8.08e-04	18	33	2	MP:0000040
MousePheno	abnormal adrenal gland morphology	CDKN1B DLGAP1 FGFR2 CHGB	8.30e-04	181	33	4	MP:0000639
MousePheno	abnormal tooth morphology	CDKN1B IRF6 FGFR2 MMP14 RBBP7	8.30e-04	318	33	5	MP:0002100
MousePheno	abnormal respiratory conducting tube morphology	ROBO1 FGFR2 MMP14	8.39e-04	79	33	3	MP:0004391
MousePheno	abnormal dental arch morphology	CDKN1B IRF6 FGFR2 MMP14 RBBP7	8.42e-04	319	33	5	MP:0030254
MousePheno	abnormal head morphology	CDKN1B ROBO1 IRF6 FGFR2 FOXI3 MMP14 RBBP7 RYR1 FOXC2	8.71e-04	1120	33	9	MP:0000432
MousePheno	lethality during fetal growth through weaning, incomplete penetrance	ROBO1 FLNB IRF6 FGFR2 COL12A1 RUNX1T1 MMP14 SCD GABRA1	8.94e-04	1124	33	9	MP:0011112
MousePheno	abnormal craniofacial morphology	CDKN1B ROBO1 FLNB IRF6 FGFR2 FOXI3 MMP14 RBBP7 RYR1 FOXC2	9.00e-04	1372	33	10	MP:0000428
MousePheno	craniofacial phenotype	CDKN1B ROBO1 FLNB IRF6 FGFR2 FOXI3 MMP14 RBBP7 RYR1 FOXC2	9.00e-04	1372	33	10	MP:0005382
MousePheno	abnormal brown adipose tissue amount	CDKN1B RYR1 FOXC2	9.35e-04	82	33	3	MP:0001778
MousePheno	abnormal chondrocyte morphology	FLNB FGFR2 MMP14	9.68e-04	83	33	3	MP:0000166
MousePheno	abnormal otic vesicle development	FGFR2 FOXC2	1.00e-03	20	33	2	MP:0006030
MousePheno	domed cranium	FGFR2 MMP14 RYR1	1.04e-03	85	33	3	MP:0000440
MousePheno	abnormal pterygoid process morphology	FOXI3 FOXC2	1.10e-03	21	33	2	MP:0004452
MousePheno	abnormal temporal bone squamous part morphology	FOXI3 FOXC2	1.10e-03	21	33	2	MP:0004423
MousePheno	exophthalmos	FGFR2 MMP14	1.10e-03	21	33	2	MP:0002750
MousePheno	perinatal lethality, complete penetrance	ROBO1 IRF6 FGFR2 FOXI3 SCD RYR1 FOXC2	1.15e-03	712	33	7	MP:0011089
MousePheno	decreased cranium length	FGFR2 MMP14	1.21e-03	22	33	2	MP:0011862
MousePheno	small ears	FOXI3 MMP14	1.21e-03	22	33	2	MP:0000018
MousePheno	abnormal pilosebaceous unit morphology	IRF6 FGFR2 SCD RYR1	1.32e-03	205	33	4	MP:0030572
MousePheno	decreased diameter of long bones	FLNB COL12A1	1.33e-03	23	33	2	MP:0008150
MousePheno	abnormal incus morphology	FOXI3 FOXC2	1.44e-03	24	33	2	MP:0005106
MousePheno	decreased skeletal muscle weight	COL12A1 RYR1	1.44e-03	24	33	2	MP:0010239
MousePheno	abnormal submandibular gland morphology	FGFR2 MMP14	1.70e-03	26	33	2	MP:0003793
MousePheno	kyphoscoliosis	FLNB COL12A1	1.83e-03	27	33	2	MP:0000069
MousePheno	abnormal hippocampal commissure morphology	ROBO1 DRAXIN	1.97e-03	28	33	2	MP:0008221
MousePheno	delayed intramembranous bone ossification	FLNB FGFR2	1.97e-03	28	33	2	MP:0003420
MousePheno	kyphosis	FLNB COL12A1 MMP14 RYR1	1.98e-03	229	33	4	MP:0000160
MousePheno	abnormal vertebral column morphology	FLNB IRF6 FGFR2 COL12A1 MMP14 RYR1 FOXC2	2.06e-03	787	33	7	MP:0004703
Domain	fn3	NFASC ROBO1 COL12A1 MYLK	3.91e-04	162	40	4	PF00041
Domain	FN3	NFASC ROBO1 COL12A1 MYLK	6.45e-04	185	40	4	SM00060
Domain	Ig_I-set	NFASC ROBO1 FGFR2 MYLK	7.12e-04	190	40	4	IPR013098
Domain	I-set	NFASC ROBO1 FGFR2 MYLK	7.12e-04	190	40	4	PF07679
Domain	FN3	NFASC ROBO1 COL12A1 MYLK	8.46e-04	199	40	4	PS50853
Domain	FN3_dom	NFASC ROBO1 COL12A1 MYLK	1.02e-03	209	40	4	IPR003961
Domain	IGc2	NFASC ROBO1 FGFR2 MYLK	1.56e-03	235	40	4	SM00408
Domain	Ig_sub2	NFASC ROBO1 FGFR2 MYLK	1.56e-03	235	40	4	IPR003598
Domain	-	NFASC ROBO1 FLNB FGFR2 COL12A1 MYLK	2.68e-03	663	40	6	2.60.40.10
Domain	Ig-like_fold	NFASC ROBO1 FLNB FGFR2 COL12A1 MYLK	3.66e-03	706	40	6	IPR013783
Domain	TF_fork_head_CS_2	FOXI3 FOXC2	4.36e-03	46	40	2	IPR030456
Domain	TF_fork_head_CS_1	FOXI3 FOXC2	4.55e-03	47	40	2	IPR018122
Domain	FORK_HEAD_3	FOXI3 FOXC2	4.94e-03	49	40	2	PS50039
Domain	FH	FOXI3 FOXC2	4.94e-03	49	40	2	SM00339
Domain	FORK_HEAD_1	FOXI3 FOXC2	4.94e-03	49	40	2	PS00657
Domain	FORK_HEAD_2	FOXI3 FOXC2	4.94e-03	49	40	2	PS00658
Domain	Forkhead	FOXI3 FOXC2	4.94e-03	49	40	2	PF00250
Domain	Fork_head_dom	FOXI3 FOXC2	4.94e-03	49	40	2	IPR001766
Domain	-	IRF6 FOXI3 FOXC2	1.13e-02	218	40	3	1.10.10.10
Domain	IG	NFASC ROBO1 FGFR2 MYLK	1.23e-02	421	40	4	SM00409
Domain	Ig_sub	NFASC ROBO1 FGFR2 MYLK	1.23e-02	421	40	4	IPR003599
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	CD93 NFASC FLNB DLGAP1 MYLK RYR1 APOL5	9.07e-08	329	40	7	17474147
Pubmed	USP33 is a Biomarker of Disease Recurrence in Papillary Thyroid Carcinoma.	ROBO1 USP33	1.29e-06	2	40	2	29533940
Pubmed	Regulation of GABA(A) receptor dynamics by interaction with purinergic P2X(2) receptors.	P2RX2 GABRA1	1.29e-06	2	40	2	21343285
Pubmed	Membrane type 1 matrix metalloproteinase is necessary for distal airway epithelial repair and keratinocyte growth factor receptor expression after acute injury.	FGFR2 MMP14	1.29e-06	2	40	2	17557804
Pubmed	Midline crossing and Slit responsiveness of commissural axons require USP33.	ROBO1 USP33	1.29e-06	2	40	2	19684588
Pubmed	Bioinformatics analysis identified MMP14 and COL12A1 as immune-related biomarkers associated with pancreatic adenocarcinoma prognosis.	COL12A1 MMP14	1.29e-06	2	40	2	34517516
Pubmed	Genomic analysis of mouse retinal development.	BRSK2 PBK CDKN1B ROBO1 FGFR2 CHGB METTL9 THRAP3 USP33	1.67e-06	1006	40	9	15226823
Pubmed	Reduced USP33 expression in gastric cancer decreases inhibitory effects of Slit2-Robo1 signalling on cell migration and EMT.	ROBO1 USP33	3.87e-06	3	40	2	30896071
Pubmed	USP33, a new player in lung cancer, mediates Slit-Robo signaling.	ROBO1 USP33	3.87e-06	3	40	2	24981056
Pubmed	FKBP3 Promotes Proliferation of Non-Small Cell Lung Cancer Cells through Regulating Sp1/HDAC2/p27.	CDKN1B FKBP3	7.73e-06	4	40	2	28839465
Pubmed	ESRP1 Mutations Cause Hearing Loss due to Defects in Alternative Splicing that Disrupt Cochlear Development.	CDKN1B FLNB FGFR2	1.57e-05	42	40	3	29107558
Pubmed	Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration.	ROBO1 USP33	1.93e-05	6	40	2	19706539
Pubmed	Fibroblast growth factor signaling regulates Dach1 expression during skeletal development.	CDKN1B FGFR2	2.70e-05	7	40	2	12203718
Pubmed	p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP.	PBK DLGAP1	2.70e-05	7	40	2	15729360
Pubmed	Novel tool to suppress cell proliferation in vivo demonstrates that myocardial and coronary vascular growth represent distinct developmental programs.	CDKN1B FGFR2	3.60e-05	8	40	2	18297725
Pubmed	Nr2f1 heterozygous knockout mice recapitulate neurological phenotypes of Bosch-Boonstra-Schaaf optic atrophy syndrome and show impaired hippocampal synaptic plasticity.	CDKN1B MMP14	3.60e-05	8	40	2	31600777
Pubmed	FGF10 promotes regional foetal cardiomyocyte proliferation and adult cardiomyocyte cell-cycle re-entry.	CDKN1B FGFR2	3.60e-05	8	40	2	25344367
Pubmed	Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.	FLNB IRF6 FGFR2 MMP14 FOXC2	3.79e-05	331	40	5	20634891
Pubmed	Fgf20 is required for sensory epithelial specification in the developing cochlea.	CDKN1B FGFR2	7.05e-05	11	40	2	18524904
Pubmed	Somatic FGFR2 is Required for Germ Cell Maintenance in the Mouse Ovary.	CDKN1B FGFR2	7.05e-05	11	40	2	36786658
Pubmed	Progression of calvarial bone development requires Foxc1 regulation of Msx2 and Alx4.	FGFR2 FOXC2	7.05e-05	11	40	2	14512019
Pubmed	Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturation.	CDKN1B FOXC2	8.45e-05	12	40	2	15342473
Pubmed	Testing reported associations of genetic risk factors for oral clefts in a large Irish study population.	IRF6 FGFR2	8.45e-05	12	40	2	19937600
Pubmed	Increased rates of vesicoureteral reflux in mice from deletion of Dicer in the peri-Wolffian duct stroma.	FGFR2 FOXC2	9.98e-05	13	40	2	32015493
Pubmed	The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity.	RBBP7 FKBP3	9.98e-05	13	40	2	12920132
Pubmed	The effects of aging on gene expression in the hypothalamus and cortex of mice.	FKBP3 SCD GABRA1	1.05e-04	79	40	3	11172053
Pubmed	Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.	FLNB RBBP7 FKBP3 THRAP3	1.09e-04	215	40	4	35973513
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	FLNB DCAF13 RBBP7 RADX FKBP3 THRAP3	1.10e-04	670	40	6	22990118
Pubmed	Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation.	FGFR2 MYLK MMP14	1.13e-04	81	40	3	39217171
Pubmed	FGFR and PTEN signaling interact during lens development to regulate cell survival.	CDKN1B FGFR2	1.16e-04	14	40	2	26764128
Pubmed	Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal.	CDKN1B FGFR2	1.34e-04	15	40	2	22235191
Pubmed	Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury.	FGFR2 SCD	1.53e-04	16	40	2	37715952
Pubmed	FOG-2 mediated recruitment of the NuRD complex regulates cardiomyocyte proliferation during heart development.	CDKN1B FGFR2	1.53e-04	16	40	2	25196150
Pubmed	Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation.	CDKN1B FGFR2	1.73e-04	17	40	2	18455718
Pubmed	Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain.	NFASC GABRA1	1.95e-04	18	40	2	31910261
Pubmed	Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling.	CDKN1B FGFR2	1.95e-04	18	40	2	25915623
Pubmed	Midline radial glia translocation and corpus callosum formation require FGF signaling.	ROBO1 FGFR2	1.95e-04	18	40	2	16715082
Pubmed	Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.	RBBP7 THRAP3	1.95e-04	18	40	2	20064376
Pubmed	Genome-wide association study of liver enzymes in korean children.	CD93 ROBO1	2.18e-04	19	40	2	24124411
Pubmed	FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate.	FGFR2 FOXC2	2.42e-04	20	40	2	19369394
Pubmed	KCTD1/KCTD15 complexes control ectodermal and neural crest cell functions, and their impairment causes aplasia cutis.	FOXI3 SCD	2.42e-04	20	40	2	38113115
Pubmed	MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis.	FGFR2 MMP14	2.67e-04	21	40	2	22632802
Pubmed	Cholesterol 7α-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders.	GCKR SCD	2.94e-04	22	40	2	27146480
Pubmed	Hypoxia inducible factor 3α plays a critical role in alveolarization and distal epithelial cell differentiation during mouse lung development.	FGFR2 SCD	3.21e-04	23	40	2	23451260
Pubmed	Constitutive activation of hedgehog signaling adversely affects epithelial cell fate during palatal fusion.	IRF6 FGFR2	3.21e-04	23	40	2	29981310
Pubmed	The mouse Foxi3 transcription factor is necessary for the development of posterior placodes.	FGFR2 FOXI3	3.50e-04	24	40	2	26550799
Pubmed	Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells.	IRF6 FKBP3	3.80e-04	25	40	2	9560157
Pubmed	Taspase1-dependent TFIIA cleavage coordinates head morphogenesis by limiting Cdkn2a locus transcription.	CDKN1B MMP14	3.80e-04	25	40	2	25664857
Pubmed	GATA3 controls the specification of prosensory domain and neuronal survival in the mouse cochlea.	CDKN1B FGFR2	4.45e-04	27	40	2	23666531
Pubmed	Purification of CpG islands using a methylated DNA binding column.	CDKN1B FKBP3	4.78e-04	28	40	2	8012384
Pubmed	Fgf10 is required for specification of non-sensory regions of the cochlear epithelium.	CDKN1B FGFR2	5.13e-04	29	40	2	25624266
Pubmed	The tumor suppressor Nf2 regulates corpus callosum development by inhibiting the transcriptional coactivator Yap.	ROBO1 DRAXIN	5.13e-04	29	40	2	25336744
Pubmed	Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis.	CDKN1B FGFR2	5.13e-04	29	40	2	14522949
Pubmed	Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function.	MYLK SCD	5.50e-04	30	40	2	27133129
Pubmed	Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis.	FGFR2 MMP14	5.87e-04	31	40	2	19898483
Pubmed	Mesodermal Pten inactivation leads to alveolar capillary dysplasia- like phenotype.	FGFR2 FOXC2	5.87e-04	31	40	2	23023706
Pubmed	Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.	COL12A1 MMP14	6.26e-04	32	40	2	23154389
Pubmed	Fgf15-mediated control of neurogenic and proneural gene expression regulates dorsal midbrain neurogenesis.	CDKN1B FGFR2	7.07e-04	34	40	2	21172336
Pubmed	Analysis of genes from inner ear developmental-stage cDNA subtraction reveals molecular regionalization of the otic capsule.	FLNB COL12A1	7.49e-04	35	40	2	15031101
Pubmed	Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.	CDKN1B FGFR2 RUNX1T1 MYLK	8.60e-04	371	40	4	25241761
Pubmed	FOXL2 modulates cartilage, skeletal development and IGF1-dependent growth in mice.	FGFR2 RYR1	8.83e-04	38	40	2	26134413
Pubmed	FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme proliferation and differentiation via Lhx8/Suv39h1 complex.	FGFR2 COL12A1	9.30e-04	39	40	2	33580754
Pubmed	Tbx2 controls lung growth by direct repression of the cell cycle inhibitor genes Cdkn1a and Cdkn1b.	CDKN1B FGFR2	9.30e-04	39	40	2	23341776
Pubmed	Quantitative trait loci affecting the 3D skull shape and size in mouse and prioritization of candidate genes in-silico.	CD93 THRAP3	9.30e-04	39	40	2	25859222
Pubmed	The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation.	PBK RBBP7 RADX FKBP3 USP33 PCYOX1	9.60e-04	1007	40	6	34597346
Pubmed	The apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state.	PBK CDKN1B	9.79e-04	40	40	2	26657772
Pubmed	SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.	CD93 FLNB COL12A1	1.04e-03	173	40	3	23979707
GeneFamily	Fibronectin type III domain containing	NFASC ROBO1 COL12A1 MYLK	1.02e-04	160	28	4	555
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	NFASC ROBO1 FGFR2 MYLK	1.05e-04	161	28	4	593
Coexpression	GSE37301_LYMPHOID_PRIMED_MPP_VS_RAG2_KO_NK_CELL_UP	IRF6 GCKR MYLK THRAP3 POLR3C	1.12e-05	199	39	5	M8863
Coexpression	SCHRAETS_MLL_TARGETS_DN	CDKN1B CD93 FOXC2	1.61e-05	33	39	3	M1904
Coexpression	VALK_AML_WITH_T_8_21_TRANSLOCATION	ROBO1 RUNX1T1	2.15e-05	5	39	2	M17966
Coexpression	SCHRAETS_MLL_TARGETS_DN	CDKN1B CD93 FOXC2	2.28e-05	37	39	3	MM1258
Coexpression	HE_LIM_SUN_FETAL_LUNG_C1_INTERM_NEUROENDOCRINE_CELL	BRSK2 ROBO1 COL12A1 CHGB RUNX1T1	4.66e-05	268	39	5	M45696
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BRSK2 NFASC COL12A1 MYLK FOXC2	7.24e-07	189	40	5	032f169e8ede653117919bf97c17f92043320b3c
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BRSK2 NFASC COL12A1 MYLK FOXC2	7.24e-07	189	40	5	07208d32afca6f93207a2ac35b647b31a9f71b7c
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC ROBO1 DLGAP1 RUNX1T1 MYLK	7.63e-07	191	40	5	c54c420a94dc749ebc67fc64c5614663f4b9798d
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC ROBO1 DLGAP1 RUNX1T1 MYLK	7.63e-07	191	40	5	cb0aee740b08f7d5fdd2717ecf7429043b277ae7
ToppCell	Control-Fibroblasts-Intermediate_pathological_FB\|Control / group, cell type (main and fine annotations)	NFASC ROBO1 RUNX1T1 MYLK MMP14	8.24e-07	194	40	5	03a269f75a481ea54aea8e6444605db8d6df493d
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-SM_activated_stress_response-SM_activated_stress_response_L.2.3.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BRSK2 NFASC COL12A1 MYLK FOXC2	8.67e-07	196	40	5	ac4c8571bd792538f8df7b9bdd90ef58405fd3b1
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BRSK2 NFASC COL12A1 MYLK FOXC2	8.67e-07	196	40	5	208ddedd29e1b9ca89cbb9b527c2e193a44cada2
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-SM_activated_stress_response\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BRSK2 NFASC COL12A1 MYLK FOXC2	8.67e-07	196	40	5	70b2e0b4ff4f1bc03fb72ace07a8a44f4b415922
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BRSK2 NFASC COL12A1 MYLK FOXC2	8.89e-07	197	40	5	8b3bf5b45e49bf1c60e4d2703b470bb890385f67
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BRSK2 NFASC COL12A1 MYLK FOXC2	8.89e-07	197	40	5	02e70768a917c5f097bc653e9e965a1000289d2e
ToppCell	ILEUM-inflamed-(8)_Fibroblasts\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	FLNB FGFR2 COL12A1 RUNX1T1 MYLK	9.34e-07	199	40	5	3a3e2bb21cd0293622b1a975263e918d9ba24265
ToppCell	distal-mesenchymal-Airway_Smooth_Muscle\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	BRSK2 NFASC COL12A1 MYLK FOXC2	9.57e-07	200	40	5	1b5ac5b3ddd4df32e940531cc020998f8cd95c2c
ToppCell	E18.5-samps-Mesenchymal-Matrix_fibroblast-matrix_-_immature_4\|E18.5-samps / Age Group, Lineage, Cell class and subclass	PBK PDE6C FOXC2 POLR3C	5.61e-06	130	40	4	169d88bffd7cd813a484d809defa638ceaca4bcb
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BRSK2 CDKN1B CHGB SCD	1.58e-05	169	40	4	d18b823836ca6fba79a2d2f10cb9966fa2623af2
ToppCell	facs-Marrow-KLS-3m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BRSK2 CDKN1B CHGB SCD	1.58e-05	169	40	4	befb9b1618ea30fbf8983bcc493853da53b809c3
ToppCell	NS-critical-d_0-4-Epithelial-Secretory\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	IRF6 FGFR2 SCD FOXC2	1.58e-05	169	40	4	aec97583b23112060437b619cb429dc32f29285f
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BRSK2 NFASC COL12A1 MYLK	1.73e-05	173	40	4	fc2602b2ce051cd4c33957d7e3d041ff8a529883
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BRSK2 NFASC COL12A1 MYLK	1.73e-05	173	40	4	901b8e6909c1f3849906fad9cee17b8f0bab050d
ToppCell	Children_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NFASC RUNX1T1 MYLK FOXC2	1.73e-05	173	40	4	5416b092321c7d9b63f0418c60f2402a138355bf
ToppCell	15-Trachea-Mesenchymal-Mesenchyme_RSPO2+\|Trachea / Age, Tissue, Lineage and Cell class	PBK ROBO1 FGFR2 MMP14	1.77e-05	174	40	4	fa0681e91724b9a51ee28b214ea5aa14e62ba1a3
ToppCell	metastatic_Brain-Endothelial_cells-Stalk-like_ECs\|Endothelial_cells / Location, Cell class and cell subclass	NFASC IRF6 GCKR RUNX1T1	1.81e-05	175	40	4	f6a6db992e803d36c866a91706b02f67e0fd3e09
ToppCell	COVID-19-kidney-REN+Pericyte\|kidney / Disease (COVID-19 only), tissue and cell type	ROBO1 COL12A1 RUNX1T1 FOXC2	1.98e-05	179	40	4	342c1cc4444f51b8dcb30d3adc98285a25669c6e
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PBK CD93 ARHGEF33 RUNX1T1	2.02e-05	180	40	4	40d4838a0ccb10d5e49266bc8a0037d27b75ccc2
ToppCell	Pericytes-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	BRSK2 NFASC FLNB FOXC2	2.07e-05	181	40	4	35c470988a93381eefa300831aabb813fa1b90bd
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ROBO1 DLGAP1 RUNX1T1 MYLK	2.07e-05	181	40	4	9ede19228ba5c0668a9c06c915510b95585216ef
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-SM_activated_stress_response-SM_activated_stress_response_L.2.3.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BRSK2 NFASC MYLK FOXC2	2.11e-05	182	40	4	97bb07478f56a937b490fba121ee603db64134a1
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-SM_activated_stress_response\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BRSK2 NFASC MYLK FOXC2	2.11e-05	182	40	4	1c1a687f728341c209b048b6715bcddd0ac20069
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC COL12A1 RUNX1T1 MYLK	2.16e-05	183	40	4	667717366cb181b8a04a347e64f0f5a4dfc6ee7f
ToppCell	AT1-AT2_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	MAGI3 FLNB COL12A1 MYLK	2.16e-05	183	40	4	6821dca076318115d360ff426eb1218cfe104063
ToppCell	Pericytes-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	BRSK2 NFASC MYLK FOXC2	2.21e-05	184	40	4	cd10d351d91a81dd6dc806cb4e0c8d7861c98e0b
ToppCell	normal_Lung-Fibroblasts-Myofibroblasts\|normal_Lung / Location, Cell class and cell subclass	ROBO1 COL12A1 MYLK MMP14	2.21e-05	184	40	4	0b336489c10e8c3c957795dd845454f03404382b
ToppCell	COVID-19-Epithelial_cells-AT2\|COVID-19 / group, cell type (main and fine annotations)	MAGI3 DLGAP1 FGFR2 SCD	2.21e-05	184	40	4	369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC ROBO1 COL12A1 RUNX1T1	2.25e-05	185	40	4	51dfe6ac7df8b330343b37e3bee71e5c65267189
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC ROBO1 COL12A1 RUNX1T1	2.25e-05	185	40	4	a8c02cec3c414f3a0da9f2d6d28ce563b0030705
ToppCell	Mesenchymal_cells-Osteo-CAR\|World / Lineage and Cell class	FGFR2 COL12A1 MMP14 P2RX2	2.25e-05	185	40	4	16f1588893d09c864e0cb4f837a1b972a1a57baa
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BRSK2 DLGAP1 CHGB GABRA1	2.30e-05	186	40	4	d1d01ce46e62944aa9864eda47e8401b5f0d2bdc
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D175\|Adult / Lineage, Cell type, age group and donor	ROBO1 DLGAP1 RUNX1T1 MYLK	2.35e-05	187	40	4	e15d2967aac248da3517bc2c7d1beaa1d5a0aa7f
ToppCell	facs-Heart-RA-3m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD93 IRF6 FGFR2 FOXC2	2.40e-05	188	40	4	4ddb11a90bf3baa7237bde304db44dfcc56aed52
ToppCell	facs-Heart-RA-3m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD93 IRF6 FGFR2 FOXC2	2.40e-05	188	40	4	e47e66906922d5c69b1aafe28face0787d3fc563
ToppCell	Hippocampus-Macroglia-POLYDENDROCYTE\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PBK CDKN1B METTL9 DRAXIN	2.40e-05	188	40	4	8bd6f2cd1aadbd6f9ed31b160f59c1eff144e1dc
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BRSK2 DLGAP1 CHGB GABRA1	2.45e-05	189	40	4	f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC ROBO1 DLGAP1 MYLK	2.45e-05	189	40	4	c734e5693808a0333139e87bd5be2597a9252afe
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC DLGAP1 COL12A1 RUNX1T1	2.50e-05	190	40	4	2306aa9dbeaef3be8484a5b236605de23cd75d4c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC DLGAP1 COL12A1 RUNX1T1	2.50e-05	190	40	4	1f83f7f24288a3b9ab33c2e113e845dba96adc8a
ToppCell	Control-Fibroblasts\|Control / group, cell type (main and fine annotations)	NFASC ROBO1 RUNX1T1 MYLK	2.50e-05	190	40	4	3a42a9b98d954685d38a741f44545898d0e3e9ce
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC DLGAP1 COL12A1 RUNX1T1	2.55e-05	191	40	4	a58c75e9580139fb370b498d95660f10f3a2a27b
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ROBO1 DLGAP1 RUNX1T1 MYLK	2.55e-05	191	40	4	b13229bb7f3713a392271aaf5dbae3edd1b9fe5a
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC DLGAP1 RUNX1T1 MYLK	2.55e-05	191	40	4	806b94f567ea09a9f443cd4091e70cdb1253ac08
ToppCell	Control-Stromal-SMC\|Stromal / Disease state, Lineage and Cell class	BRSK2 NFASC MYLK FOXC2	2.55e-05	191	40	4	2da83c493e60ad0278848957645277d76737a188
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC COL12A1 RUNX1T1 FOXC2	2.55e-05	191	40	4	7b0d42a877540dbb346a76a62403e0d5d3e07fa6
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NFASC ROBO1 RUNX1T1 MYLK	2.55e-05	191	40	4	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC COL12A1 RUNX1T1 FOXC2	2.55e-05	191	40	4	cd854b9c426924fdc84bf7f411f6dea447143e79
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC DLGAP1 COL12A1 RUNX1T1	2.60e-05	192	40	4	9093a9e94a25682d109a7f6edc256a25a61103a0
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ROBO1 DLGAP1 RUNX1T1 MYLK	2.60e-05	192	40	4	6f4ef24dab544681304b7f8a9dc073e7edaa4cf5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC ROBO1 COL12A1 RUNX1T1	2.60e-05	192	40	4	5105e4b577408b4e1a62d0a44c23c2b830ccad88
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC ROBO1 COL12A1 RUNX1T1	2.60e-05	192	40	4	d3c1ad4667a1e223a83ca0fcd5991a0b96f1199a
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_2-SCMF\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	COL12A1 RUNX1T1 MYLK MMP14	2.60e-05	192	40	4	67e845e513e76e820f55e2f0d15eb16f2944d05c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC DLGAP1 COL12A1 RUNX1T1	2.60e-05	192	40	4	9ed5d49621ec1aa01716dc369bba1450b5f015f5
ToppCell	Pericytes\|World / lung cells shred on cell class, cell subclass, sample id	BRSK2 NFASC MYLK FOXC2	2.60e-05	192	40	4	057ad22b878c0c5fb59ed1412ca13db945c57a5a
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NFASC ROBO1 RUNX1T1 MYLK	2.60e-05	192	40	4	99ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell	LPS_only-Stromal_mesenchymal\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DLGAP1 RUNX1T1 MYLK MMP14	2.60e-05	192	40	4	162d8b5858d150ecbbd1c9bf2b19c6c9cd50a158
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ROBO1 DLGAP1 RUNX1T1 MYLK	2.60e-05	192	40	4	3d0cb19f037f604253d7d728689aeaa94251e92b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC COL12A1 RUNX1T1 MYLK	2.66e-05	193	40	4	f1199518c3626fd29bfce65070dd21a660671213
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ROBO1 DLGAP1 RUNX1T1 MYLK	2.66e-05	193	40	4	99525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCell	COVID-19-Fibroblasts-Other_FB\|COVID-19 / group, cell type (main and fine annotations)	ROBO1 COL12A1 RUNX1T1 MYLK	2.66e-05	193	40	4	e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D231\|Adult / Lineage, Cell type, age group and donor	NFASC ROBO1 RUNX1T1 MYLK	2.66e-05	193	40	4	ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCell	human_hepatoblastoma-Tumor_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	MAGI3 ROBO1 FLNB DLGAP1	2.66e-05	193	40	4	503a979328c68b096680b71359a26f02fafdff35
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-1\|TCGA-Endometrium / Sample_Type by Project: Shred V9	PBK ROBO1 DRAXIN SCD	2.66e-05	193	40	4	c2673d86f7d7b849788036032a93a6d136a70040
ToppCell	Mesenchymal-matrix_fibroblast_1_cell\|World / Lineage, Cell type, age group and donor	ROBO1 DLGAP1 RUNX1T1 MYLK	2.66e-05	193	40	4	acad568621ed677031797b8c2e34dafea798d681
ToppCell	LPS-antiTNF-Stromal_mesenchymal\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ROBO1 DLGAP1 RUNX1T1 MYLK	2.71e-05	194	40	4	6e13549f697f7478b34fe71f7dd9d63c5d3db22e
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC ROBO1 RUNX1T1 MYLK	2.71e-05	194	40	4	90efdbd7f1c85fd7fd622b10340250b1d8fc1197
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC ROBO1 RUNX1T1 MYLK	2.71e-05	194	40	4	df82cce5ebeb73740b02cf816c6df82253cfd566
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ROBO1 DLGAP1 RUNX1T1 MYLK	2.71e-05	194	40	4	89b706af2b25991fc2707eb24f49ba6ff3ae01f7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC COL12A1 RUNX1T1 MYLK	2.71e-05	194	40	4	ebb038f94f49f5c655578d1b018676e10c6b7e3c
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC COL12A1 MYLK FOXC2	2.77e-05	195	40	4	e10b21e4dba4483efc4c82d6e395524246ca14a8
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ROBO1 COL12A1 MYLK MMP14	2.77e-05	195	40	4	2514c1f23424b5fc664d326d31ffd22bafe74ef8
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC COL12A1 RUNX1T1 MYLK	2.77e-05	195	40	4	803f714d91f2d97ecbee8c15a5139fd9310f66c7
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell\|Adult / Lineage, Cell type, age group and donor	NFASC ROBO1 RUNX1T1 MYLK	2.77e-05	195	40	4	61c9e09fc84d1012e472185d70ad0a06cee30d6e
ToppCell	COVID-19-Fibroblasts-Alveolar_FB\|COVID-19 / group, cell type (main and fine annotations)	NFASC ROBO1 RUNX1T1 MYLK	2.77e-05	195	40	4	603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC COL12A1 MYLK FOXC2	2.77e-05	195	40	4	9ab3c5b0fb12d406408122a535b717bfe184bbcf
ToppCell	Fibroblasts-Pericytes\|Fibroblasts / lung cells shred on cell class, cell subclass, sample id	BRSK2 NFASC MYLK FOXC2	2.77e-05	195	40	4	c2ebc0b33bda9b35b9ef26d69e5d2c6acfdb6ff1
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC COL12A1 MYLK FOXC2	2.77e-05	195	40	4	21263d138c81f6a0219f2cd93126cfafd35732b2
ToppCell	COVID-19-kidney-Fibroblast-2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	NFASC ROBO1 COL12A1 RUNX1T1	2.77e-05	195	40	4	3d62ce1c696f47d4d7eb0c5bb0eec2c24b122bb2
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC COL12A1 RUNX1T1 MYLK	2.77e-05	195	40	4	4f70157d42a16ff0259bc24a62803c4df4285c44
ToppCell	356C-Fibroblasts-Fibroblast-K_(Pericytes)\|356C / Donor, Lineage, Cell class and subclass (all cells)	BRSK2 NFASC MYLK FOXC2	2.82e-05	196	40	4	a5cc4f76e1a3825aaccba9a686d7da6f7e4300ff
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC COL12A1 RUNX1T1 FOXC2	2.82e-05	196	40	4	b8759e6231e0254797d6c30930407b79440c57bb
ToppCell	(5)_Fibroblast-K_(Pericytes)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	BRSK2 NFASC MYLK FOXC2	2.82e-05	196	40	4	e3c89c5bd674289738d5590ebfd30c605f5156a5
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ROBO1 COL12A1 MYLK MMP14	2.82e-05	196	40	4	e4d04e1f82779e8afd4e32bbe38d1d3f6f64ab50
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ROBO1 COL12A1 MYLK MMP14	2.82e-05	196	40	4	f0fd7db22985d2bc84dc8bcbdb2d552e280121dd
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-immature_mesenchymal_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ROBO1 COL12A1 RUNX1T1 MMP14	2.82e-05	196	40	4	cbfe01ba8071864e19b37028236ae35789f630fe
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC COL12A1 RUNX1T1 MYLK	2.82e-05	196	40	4	2b36b9a40fe415917afccff99ad9c3474e087d0d
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC COL12A1 RUNX1T1 MYLK	2.82e-05	196	40	4	fa445f4240c521cf04eb2e2f79a5c55fda31209a
ToppCell	367C-Fibroblasts-Fibroblast-K_(Pericytes)\|367C / Donor, Lineage, Cell class and subclass (all cells)	BRSK2 NFASC MYLK FOXC2	2.82e-05	196	40	4	c390ef0adff35111989a30dff86b7c5db1a89873
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC COL12A1 RUNX1T1 MYLK	2.82e-05	196	40	4	802f61e78a9a1030a86c4a980c398a73cd4d1574
ToppCell	367C-Fibroblasts-Fibroblast-K_(Pericytes)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	BRSK2 NFASC MYLK FOXC2	2.82e-05	196	40	4	2f76f050083483f0880639e6c34ff349caac3503
ToppCell	356C-Fibroblasts-Fibroblast-K_(Pericytes)-\|356C / Donor, Lineage, Cell class and subclass (all cells)	BRSK2 NFASC MYLK FOXC2	2.82e-05	196	40	4	476812fc1422aca8010d771eff11fa6081f15a2d
ToppCell	nucseq-Mesenchymal-Fibroblastic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NFASC ROBO1 RUNX1T1 MYLK	2.82e-05	196	40	4	7d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC COL12A1 MYLK FOXC2	2.82e-05	196	40	4	545d2e4469924d333e3f655f559c899fa1260196
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC COL12A1 MYLK FOXC2	2.88e-05	197	40	4	bc6c530330907a5ec823cc243c8e9c9e340cfb9c
ToppCell	COVID-19-Fibroblasts-Intermediate_pathological_FB\|COVID-19 / group, cell type (main and fine annotations)	ROBO1 COL12A1 RUNX1T1 MYLK	2.88e-05	197	40	4	f1c8936986123a3151140c374fcd62d6705c530b
Disease	transitional cell carcinoma (is_marker_for)	CDKN1B FGFR2 MMP14	8.02e-05	63	39	3	DOID:2671 (is_marker_for)
Disease	cleft palate (is_implicated_in)	FLNB IRF6	1.11e-04	12	39	2	DOID:674 (is_implicated_in)
Disease	Skin Abnormalities	IRF6 FGFR2	1.32e-04	13	39	2	C0037268
Disease	lysophosphatidylcholine 16:1 measurement	GCKR SCD	1.53e-04	14	39	2	EFO_0010358
Disease	Cleft Palate	IRF6 FGFR2 FOXC2	1.70e-04	81	39	3	C0008925
Disease	leptin measurement	CD93 GCKR FGFR2	1.70e-04	81	39	3	EFO_0005000
Disease	Limb Deformities, Congenital	IRF6 FGFR2	2.29e-04	17	39	2	C0206762
Disease	lysophosphatidylethanolamine 20:4 measurement	MAGI3 GCKR	6.76e-04	29	39	2	EFO_0010370
Disease	interleukin 4 measurement	MAGI3 FLNB	1.04e-03	36	39	2	EFO_0008184
Disease	Craniofacial Abnormalities	IRF6 FGFR2 FOXC2	1.15e-03	156	39	3	C0376634
Disease	rheumatoid arthritis, Crohn's disease	MAGI3 SNAPC4	1.16e-03	38	39	2	EFO_0000384, EFO_0000685
Disease	Cleft upper lip	IRF6 FGFR2	1.22e-03	39	39	2	C0008924
Disease	lysophosphatidylcholine 20:3 measurement	DLGAP1 GCKR	1.29e-03	40	39	2	EFO_0010362

Protein segments in the cluster

Peptide	Gene	Start	Entry
KPGDEIYPRDENGKW	AKR1D1	126	P51857
KEKAPDVFDWGSSGP	CD93	241	Q9NPY3
RQPKDGKEWGEEYVT	ARHGEF33	221	A8MVX0
PQDEWTGYTPRGKDD	DLGAP1	321	O14490
EGKYEWQEVEKGSLP	CDKN1B	71	P46527
WKMDGPGYGDEEEPL	DCAF13	136	Q9NV06
DSEYPKNIKVWEGIP	MMP14	446	P50281
DPYGDIWLTDKQPEE	RADX	196	Q6NSI4
AGVSEYELPEDPKWE	FGFR2	461	P21802
VPRDEDDPGKGNYWT	FOXI3	206	A8MTJ6
KIEGYPDPEVVWFKD	MYLK	1831	Q15746
KAPEDCEDGELPYGW	MAGI3	331	Q5TCQ9
PASGYVPEEIWKKAE	RUNX1T1	436	Q06455
KHIWYIGGKNEPEPE	BRSK2	266	Q8IWQ3
DGSCDVKYWPKEPGE	FLNB	601	O75369
EKEDPEPSTDGTYVW	PCYOX1	391	Q9UHG3
YDEWPIKLGEVEPYK	PDE6C	291	P51160
PYVENVGGKWEKPSE	METTL9	246	Q9H1A3
GYAWDGKSVVPEKPK	GABRA1	341	P14867
DDKKPGKGSYWTLDP	FOXC2	136	Q99958
VQWLPEVTKPEGKDY	RBBP7	46	Q16576
IETPEPGKWELSGYE	GCKR	11	Q14397
KVWDVEEYVKPPEGG	P2RX2	91	Q9UBL9
PDIAWYKKGGDLPSD	NFASC	276	O94856
VPGEKPGTKVDDYWE	DNAH1	2966	Q9P2D7
PGTKVDDYWEPGKGL	DNAH1	2971	Q9P2D7
TDYEDLKPDGWPSAK	DRAXIN	236	Q8NBI3
TWEPAPGEVKGYKVT	COL12A1	1106	Q99715
IPKDSVGTQEWYPKD	DEFB112	96	Q30KQ8
EIEPEWAYGKKGQPD	FKBP3	191	Q00688
KGYPGVQAPEDLEWE	CHGB	346	P05060
PPKKEEAGGEFWGEL	RYR1	4531	P21817
KYQEGVDDPDPAKWK	IRF6	66	O14896
KVIYGGEVWGKSPEP	APOL5	31	Q9BWW9
EKSGKWEGLVYAPPG	THRAP3	466	Q9Y2W1
TTDNKEPIPDDGIYW	POLR3C	221	Q9BUI4
DKEGPSPKVEYVWRN	SCD	61	O00767
WYKGGERVETDKDDP	ROBO1	101	Q9Y6N7
YIGTEPWKPKEAVEE	PBK	206	Q96KB5
DPGLKKGYWAPEEDA	SNAPC4	396	Q5SXM2
REWESFVKGKDGDPP	USP33	856	Q8TEY7