Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionacetylcholine receptor regulator activity

SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

1.29e-0927375GO:0030548
GeneOntologyMolecularFunctionneurotransmitter receptor regulator activity

SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

1.57e-0928375GO:0099602
GeneOntologyMolecularFunctionprotein kinase binding

APBA1 SPDYE21 SPDYE5 SPDYE18 SPDYE2B SPDYE6 SPDYE16 SPDYE2

1.61e-04873378GO:0019901
GeneOntologyMolecularFunctionkinase binding

APBA1 SPDYE21 SPDYE5 SPDYE18 SPDYE2B SPDYE6 SPDYE16 SPDYE2

3.28e-04969378GO:0019900
GeneOntologyMolecularFunctionsignaling receptor regulator activity

SPDYE5 IGSF1 SPDYE2B SPDYE6 SPDYE16 SPDYE2

8.65e-04616376GO:0030545
GeneOntologyBiologicalProcesspositive regulation of cyclin-dependent protein serine/threonine kinase activity

SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

6.28e-1025365GO:0045737
GeneOntologyBiologicalProcesspositive regulation of cyclin-dependent protein kinase activity

SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

1.16e-0928365GO:1904031
GeneOntologyBiologicalProcessregulation of cyclin-dependent protein serine/threonine kinase activity

SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

6.61e-0796365GO:0000079
GeneOntologyBiologicalProcessregulation of cyclin-dependent protein kinase activity

SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

8.10e-07100365GO:1904029
GeneOntologyBiologicalProcesspositive regulation of protein serine/threonine kinase activity

SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

2.03e-05193365GO:0071902
GeneOntologyBiologicalProcessregulation of protein serine/threonine kinase activity

SPDYE5 SPDYE2B TNXB SPDYE6 SPDYE16 SPDYE2

3.29e-05358366GO:0071900
GeneOntologyBiologicalProcesspositive regulation of vascular endothelial growth factor signaling pathway

JCAD TNXB

1.06e-049362GO:1900748
GeneOntologyBiologicalProcessformation of translation preinitiation complex

MCTS2 MCTS1

1.32e-0410362GO:0001731
GeneOntologyBiologicalProcesspositive regulation of protein kinase activity

SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

3.34e-04350365GO:0045860
GeneOntologyBiologicalProcessnegative regulation of leukocyte degranulation

BCR HLA-F

3.96e-0417362GO:0043301
GeneOntologyBiologicalProcessregulation of protein kinase activity

SPDYE5 SPDYE2B TNXB SPDYE6 SPDYE16 SPDYE2

6.02e-04611366GO:0045859
GeneOntologyBiologicalProcesspositive regulation of kinase activity

SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

6.50e-04405365GO:0033674
GeneOntologyBiologicalProcesspositive regulation of cell cycle

SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

6.65e-04407365GO:0045787
DomainSpeedy

SPDYE21 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

1.52e-1411366IPR020984
DomainSpy1

SPDYE21 SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

1.52e-1411366PF11357
DomainRhoGAP

ARHGAP32 BCR

6.35e-0362362SM00324
DomainRhoGAP

ARHGAP32 BCR

6.55e-0363362PF00620
DomainRHOGAP

ARHGAP32 BCR

6.76e-0364362PS50238
DomainRhoGAP_dom

ARHGAP32 BCR

6.76e-0364362IPR000198
Domain-

ARHGAP32 BCR

6.76e-03643621.10.555.10
Pubmed

Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene.

SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

1.71e-13939536272447
Pubmed

Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.

SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

1.74e-121339515611625
Pubmed

Characterization of a new family of cyclin-dependent kinase activators.

SPDYE5 SPDYE2B SPDYE6 SPDYE16 SPDYE2

8.32e-121739515574121
Pubmed

Evolution of the Cdk-activator Speedy/RINGO in vertebrates.

SPDYE6 SPDYE2

3.67e-06339222763696
Pubmed

Spatiotemporal expression of retrogene-host pair Mcts2/H13 in mouse embryo, and Mcts2 has no influence on H13 transcription pattern in NIH/3T3 cells.

MCTS2 MCTS1

3.67e-06339224063864
Pubmed

A case-by-case evolutionary analysis of four imprinted retrogenes.

MCTS2 MCTS1

7.34e-06439221166792
Pubmed

Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis.

BCR USP9X

7.34e-06439221248063
Pubmed

The DNA sequence of human chromosome 7.

SPDYE21 SPDYE5 SPDYE2B ZNF282 SPDYE6 SPDYE16

9.20e-0644139612853948
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

ZFHX2 ARHGAP32 SPDYE18 TNXB USP9X SPDYE2

3.25e-0555239610737800
Pubmed

A HECT domain E3 enzyme assembles novel polyubiquitin chains.

UBR1 USP9X

3.42e-05839211278995
Pubmed

A screen for retrotransposed imprinted genes reveals an association between X chromosome homology and maternal germ-line methylation.

MCTS2 MCTS1

3.42e-05839217291163
Pubmed

Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1.

UBR1 GANC

9.48e-051339212434312
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

ARHGAP32 IGF2R USP9X EPB41L2 TM9SF3 SYNCRIP

1.28e-0470839639231216
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

BLMH JCAD ARHGAP32 MTMR11 IGF2R CNTROB USP9X

1.47e-04104939727880917
Pubmed

Recombination in the class III region of the mouse major histocompatibility complex.

TNXB HLA-F

2.79e-04223927916002
Pubmed

Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.

ARHGAP32 STK38L USP9X ZC3H13 SYNCRIP

3.62e-0455139534728620
Pubmed

Many sequence variants affecting diversity of adult human height.

MTMR11 BCR TNXB

5.58e-0414339318391951
Pubmed

Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.

IRF6 IGF2R SDHAF2 HLA-F

7.80e-0437139415747579
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

IGF2R USP9X ZC3H13 EPB41L2 SYNCRIP

7.80e-0465339522586326
Pubmed

Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation.

STK38L USP9X SYNCRIP

9.53e-0417239323184937
Pubmed

Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.

STK38L USP9X EPB41L2 BRWD1

1.02e-0339939437536630
CytobandEnsembl 112 genes in cytogenetic band chr7q11

SPDYE21 SPDYE5 SPDYE18 SPDYE16

8.30e-05271394chr7q11
Cytoband7q22.1

SPDYE2B SPDYE6 SPDYE2

1.24e-041133937q22.1
CytobandEnsembl 112 genes in cytogenetic band chr15q15

UBR1 JMJD7 GANC

2.70e-04147393chr15q15
CytobandEnsembl 112 genes in cytogenetic band chr7q22

SPDYE2B SPDYE6 SPDYE2

8.62e-04219393chr7q22
Cytoband7q11.23

SPDYE5 SPDYE18

3.11e-03973927q11.23
GeneFamilySpeedy/RINGO cell cycle regulator family

SPDYE5 SPDYE2B SPDYE6 SPDYE2

1.40e-0912254756
Diseaseleukemia (is_implicated_in)

ACSL6 BCR

9.97e-0513342DOID:1240 (is_implicated_in)
Diseaserheumatoid arthritis, COVID-19

TNXB HLA-F

2.48e-0364342EFO_0000685, MONDO_0100096
Diseasepulse pressure measurement, alcohol drinking

JCAD C1orf167

2.96e-0370342EFO_0004329, EFO_0005763
Diseasesusceptibility to shingles measurement

TNXB HLA-F

3.94e-0381342EFO_0008401
Diseasepsoriatic arthritis

TNXB HLA-F

4.53e-0387342EFO_0003778

Protein segments in the cluster

PeptideGeneStartEntry
EWTKDTPVPEPMELR

C1orf167

176

Q5SNV9
WKAQFPDSEPPRMEL

BCR

11

P11274
AAIPRMEPREPWVEQ

HLA-F

61

P30511
IEPWLNQIMPKKDPV

MCTS1

36

Q9ULC4
IEPWLNQIMPKKDPV

MCTS2

36

A0A3B3IRV3
PPIPLMETAEDWETE

MTMR11

191

A4FU01
EEEGPWDQMPLPDRD

CSRNP1

46

Q96S65
VVDEEAMEKVPWIPL

JMJD7

226

P0C870
PEMRVEPQPRMWVPE

JCAD

886

Q9P266
MESTPEPRPNEWEKR

EPB41L2

656

O43491
EWADPIEDPDPEVMA

SYNCRIP

321

O60506
SQPVMRPLWVEFPDE

GANC

691

Q8TET4
KEMERPWVRQPSAPE

ARHGAP32

1946

A7KAX9
EETEIVMPTPKPELW

IGSF1

581

Q8N6C5
PDEPKEPIWVMRQDI

APBA1

371

Q02410
TEIEKLSPWDMEPIP

BRWD1

1111

Q9NSI6
VLEQEPIILPAWDPM

BLMH

436

Q13867
EPEKEERRVWTMPPM

CNTROB

591

Q8N137
TDSQKDMIEIPLPPW

SDHAF2

41

Q9NX18
DMIEIPLPPWQERTD

SDHAF2

46

Q9NX18
VWPKTEPLEMEVPQA

IRF6

191

O14896
ETEWLMEEIQLPPPR

IGF2R

2366

P11717
DDMINRPRWVVPVLP

USP9X

76

Q93008
MNWKETLVFPPEVPI

STK38L

336

Q9Y2H1
KVLAPEPEEIWVAEM

SPDYE2B

161

A6NHP3
VVPDPEVMPSWAQKR

ACSL6

601

Q9UKU0
MVPEEEPQDREKGLW

CLEC4C

1

Q8WTT0
PKAELAEREWERPPM

ZFHX2

1401

Q9C0A1
KVLAPEPEEIWVVEM

SPDYE16

121

A6NNV3
KVLAPEPEEIWVAEM

SPDYE18

161

P0DV79
KVLAPEPEEIWVAEM

SPDYE21

161

A0A494C086
KVLAPEPEEIWVAEM

SPDYE2

161

Q495Y8
KVLAPEPEEIWVAEM

SPDYE5

161

A6NIY4
KVLAPEPEEIWVAEM

SPDYE6

161

P0CI01
EIRETSAKVNWMPPP

TNXB

3766

P22105
EPWNMKRHELVKEPP

ZNF728

61

P0DKX0
VVEMTIWEEEKELPP

UBR1

201

Q8IWV7
NAVPRPIPEKKWFME

TM9SF3

431

Q9HD45
KVLAPEPEEIWVAEM

nan

121

A6NJR5
WEQRHPEEREIPMDP

ZNF282

261

Q9UDV7
EEKMPDPLDVIDVDW

ZC3H13

1486

Q5T200