Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionstructural constituent of postsynaptic actin cytoskeleton

POTEE ACTBL2 ACTB ACTG1 POTEKP POTEI

4.78e-1211966GO:0098973
GeneOntologyMolecularFunctionstructural constituent of postsynapse

POTEE ACTBL2 ACTB ACTG1 POTEKP POTEI

8.64e-0932966GO:0099186
GeneOntologyMolecularFunctionstructural constituent of synapse

POTEE ACTBL2 ACTB ACTG1 POTEKP POTEI

4.81e-0842966GO:0098918
GeneOntologyMolecularFunctionstructural constituent of cytoskeleton

ACTL7B POTEE ACTBL2 ACTB ACTG1 POTEKP POTEI

3.10e-06130967GO:0005200
GeneOntologyMolecularFunctionkinase binding

DAB2IP POTEE CDK5RAP3 NBEAL1 ACTBL2 ACTB ACTG1 POTEKP BCL11A TEX14 POTEI MAPK8IP2 RYR2 NIN

2.14e-049699614GO:0019900
GeneOntologyMolecularFunctionprotein kinase binding

DAB2IP POTEE CDK5RAP3 NBEAL1 ACTBL2 ACTB ACTG1 POTEKP BCL11A TEX14 POTEI MAPK8IP2 RYR2

2.74e-048739613GO:0019901
GeneOntologyMolecularFunctionhistone H3K4 monomethyltransferase activity

KMT2D SETD1B

6.29e-048962GO:0140945
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

DAB2IP LLGL2 DOCK7 DGKI ARHGAP9 ARHGAP11A ARHGAP11B DENND3 ARHGEF10L

7.49e-04507969GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

DAB2IP LLGL2 DOCK7 DGKI ARHGAP9 ARHGAP11A ARHGAP11B DENND3 ARHGEF10L

7.49e-04507969GO:0030695
GeneOntologyMolecularFunctionhistone H3K4 trimethyltransferase activity

KMT2D SETD1B

1.00e-0310962GO:0140999
GeneOntologyBiologicalProcesspostsynaptic actin cytoskeleton organization

POTEE ACTBL2 ACTB ACTG1 POTEKP POTEI

5.12e-0931946GO:0098974
GeneOntologyBiologicalProcesspostsynaptic cytoskeleton organization

POTEE ACTBL2 ACTB ACTG1 POTEKP POTEI

1.11e-0835946GO:0099188
GeneOntologyBiologicalProcesspostsynapse organization

GPHN POTEE ASIC2 ACTBL2 ACTB DOCK7 ACTG1 POTEKP POTEI ADGRL3

1.65e-063139410GO:0099173
GeneOntologyBiologicalProcessneuron projection morphogenesis

DAB2IP POTEE NOG SYNE1 ACTBL2 ACTB DOCK7 ACTG1 POTEKP BCL11A POTEI PARD3 MAPK8IP2 NIN

1.57e-058029414GO:0048812
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

DAB2IP POTEE NOG SYNE1 ACTBL2 ACTB DOCK7 ACTG1 POTEKP BCL11A POTEI PARD3 MAPK8IP2 NIN

1.98e-058199414GO:0120039
GeneOntologyBiologicalProcesscell projection morphogenesis

DAB2IP POTEE NOG SYNE1 ACTBL2 ACTB DOCK7 ACTG1 POTEKP BCL11A POTEI PARD3 MAPK8IP2 NIN

2.17e-058269414GO:0048858
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

POTEE NOG SYNE1 ACTBL2 ACTB DOCK7 ACTG1 POTEKP BCL11A POTEI PARD3 MAPK8IP2 NIN

3.40e-057489413GO:0048667
GeneOntologyBiologicalProcessaxonogenesis

POTEE NOG ACTBL2 ACTB DOCK7 ACTG1 POTEKP BCL11A POTEI PARD3 NIN

5.31e-055669411GO:0007409
GeneOntologyBiologicalProcessactin filament-based process

AKAP6 POTEE LLGL2 CLN3 ACTBL2 PHACTR4 ACTB ACTG1 POTEKP POTEI MYO15A PARD3 RYR2 ARHGEF10L

6.39e-059129414GO:0030029
GeneOntologyBiologicalProcesssynapse organization

DAB2IP GPHN POTEE ASIC2 CLN3 ACTBL2 ACTB DOCK7 ACTG1 POTEKP POTEI ADGRL3

6.47e-056859412GO:0050808
GeneOntologyBiologicalProcessplatelet activation

PIK3CG ACTB ACTG1 DGKI C1QTNF1 TREML1

8.58e-05158946GO:0030168
GeneOntologyBiologicalProcessregulation of transepithelial transport

ACTB ACTG1

1.23e-044942GO:0150111
GeneOntologyBiologicalProcessregulation of small GTPase mediated signal transduction

DAB2IP PIK3CG DGKI ARHGAP9 ARHGAP11A ARHGAP11B DENND3 ARHGEF10L

1.42e-04333948GO:0051056
GeneOntologyBiologicalProcessaxon development

POTEE NOG ACTBL2 ACTB DOCK7 ACTG1 POTEKP BCL11A POTEI PARD3 NIN

1.62e-046429411GO:0061564
GeneOntologyBiologicalProcesssmall GTPase-mediated signal transduction

DAB2IP PIK3CG PHACTR4 DOCK7 DGKI ARHGAP9 ARHGAP11A ARHGAP11B DENND3 ARHGEF10L

1.70e-045389410GO:0007264
GeneOntologyBiologicalProcessblood coagulation

PIK3CG ACTB ACTG1 DGKI C1QTNF1 TREML1 ITPK1

1.88e-04260947GO:0007596
GeneOntologyBiologicalProcesscoagulation

PIK3CG ACTB ACTG1 DGKI C1QTNF1 TREML1 ITPK1

2.16e-04266947GO:0050817
GeneOntologyBiologicalProcesshemostasis

PIK3CG ACTB ACTG1 DGKI C1QTNF1 TREML1 ITPK1

2.26e-04268947GO:0007599
GeneOntologyCellularComponentNuA4 histone acetyltransferase complex

POTEE ACTBL2 EPC1 ACTB ACTG1 POTEKP POTEI

1.06e-1032967GO:0035267
GeneOntologyCellularComponentH4/H2A histone acetyltransferase complex

POTEE ACTBL2 EPC1 ACTB ACTG1 POTEKP POTEI

1.06e-1032967GO:0043189
GeneOntologyCellularComponentH4 histone acetyltransferase complex

POTEE ACTBL2 EPC1 ACTB ACTG1 POTEKP POTEI

1.36e-0945967GO:1902562
GeneOntologyCellularComponenthistone acetyltransferase complex

POTEE ACTBL2 EPC1 ACTB ACTG1 POTEKP POTEI

2.55e-0794967GO:0000123
GeneOntologyCellularComponentprotein acetyltransferase complex

POTEE ACTBL2 EPC1 ACTB ACTG1 POTEKP POTEI

5.10e-07104967GO:0031248
GeneOntologyCellularComponentacetyltransferase complex

POTEE ACTBL2 EPC1 ACTB ACTG1 POTEKP POTEI

7.02e-07109967GO:1902493
GeneOntologyCellularComponentactin filament

POTEE ACTBL2 ACTB ACTG1 POTEKP POTEI

5.79e-05146966GO:0005884
GeneOntologyCellularComponentactin cytoskeleton

ACTL7B POTEE LLGL2 ACTBL2 ACTB ACTG1 ACTG2 POTEKP POTEI MYO15A DHX9

6.70e-055769611GO:0015629
GeneOntologyCellularComponentintracellular protein-containing complex

POTEE CCT8L2 RPAP1 ACTBL2 EPC1 ACTB ACTG1 DGKI POTEKP POTEI CCT8L1P CEP164 DHX9 NIN

1.37e-049729614GO:0140535
GeneOntologyCellularComponentaxon

DAB2IP POTEE NOG ACTBL2 ACTB DOCK7 ACTG1 DGKI POTEKP POTEI PARD3 ADGRL3 NIN

2.15e-048919613GO:0030424
GeneOntologyCellularComponentdense body

ACTB ACTG1

4.32e-047962GO:0097433
GeneOntologyCellularComponentblood microparticle

POTEE IGHA2 ACTB ACTG1 ACTG2

5.35e-04144965GO:0072562
GeneOntologyCellularComponentSchaffer collateral - CA1 synapse

ACTB APBA2 ACTG1 DGKI ADGRL3

7.46e-04155965GO:0098685
GeneOntologyCellularComponentciliary transition fiber

CEP164 NIN

9.17e-0410962GO:0097539
GeneOntologyCellularComponentjunctional sarcoplasmic reticulum membrane

AKAP6 RYR2

9.17e-0410962GO:0014701
GeneOntologyCellularComponentchaperonin-containing T-complex

CCT8L2 CCT8L1P

1.12e-0311962GO:0005832
GeneOntologyCellularComponenttransferase complex

POTEE KMT2D SETD1B RPAP1 PIK3CG ACTBL2 EPC1 ACTB ACTG1 POTEKP POTEI PARD3

1.51e-039639612GO:1990234
GeneOntologyCellularComponentpostsynapse

GPHN PRR12 CACNA1E ASIC2 SYNE1 ACTB APBA2 ACTG1 DGKI BCL11A ADGRL3 MAPK8IP2

2.40e-0310189612GO:0098794
GeneOntologyCellularComponentsupramolecular fiber

POTEE CDK5RAP3 SYNE1 ACTBL2 ACTB ACTG1 ACTG2 POTEKP MTCL1 POTEI RYR2 AHNAK2 NIN

2.82e-0311799613GO:0099512
GeneOntologyCellularComponentsupramolecular polymer

POTEE CDK5RAP3 SYNE1 ACTBL2 ACTB ACTG1 ACTG2 POTEKP MTCL1 POTEI RYR2 AHNAK2 NIN

2.99e-0311879613GO:0099081
DomainActin_CS

POTEE ACTBL2 ACTB ACTG1 ACTG2 POTEI

1.06e-1016946IPR004001
DomainActin

ACTL7B POTEE ACTBL2 ACTB ACTG1 ACTG2 POTEI

1.55e-1031947IPR004000
DomainActin

ACTL7B POTEE ACTBL2 ACTB ACTG1 ACTG2 POTEI

1.55e-1031947PF00022
DomainACTIN

ACTL7B POTEE ACTBL2 ACTB ACTG1 ACTG2 POTEI

1.55e-1031947SM00268
DomainACTINS_2

POTEE ACTBL2 ACTB ACTG1 ACTG2 POTEI

1.64e-1017946PS00432
DomainActin/actin-like_CS

POTEE ACTBL2 ACTB ACTG1 ACTG2 POTEI

2.44e-1018946IPR020902
DomainACTINS_ACT_LIKE

POTEE ACTBL2 ACTB ACTG1 ACTG2 POTEI

3.56e-1019946PS01132
DomainACTINS_1

ACTBL2 ACTB ACTG1 ACTG2

4.15e-088944PS00406
PathwayWP_COMMON_PATHWAYS_UNDERLYING_DRUG_ADDICTION

ACTB ACTG1 ACTG2 PPP1R1A

3.24e-0541634M39655
PathwayWP_MECHANOREGULATION_AND_PATHOLOGY_OF_YAPTAZ_VIA_HIPPO_AND_NONHIPPO_MECHANISMS

MAP4K3 ACTB ACTG1 ACTG2

5.59e-0547634M39829
PathwayREACTOME_RHO_GTPASE_CYCLE

POTEE SLC4A7 ACTB DOCK7 ACTG1 ARHGAP9 ARHGAP11A ARHGAP11B ARHGEF10L

1.63e-04450639M27078
PathwayKEGG_MEDICUS_REFERENCE_ANXA2_S100A10_REGULATED_ACTIN_CYTOSKELETON

ACTB ACTG1

1.95e-045632M49034
PathwayKEGG_ADHERENS_JUNCTION

ACTB ACTG1 PARD3 SMAD2

3.13e-0473634M638
PathwayKEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPB_TO_ARNO_ARF_ACTB_G_SIGNALING_PATHWAY

PIK3CG ACTB ACTG1

3.17e-0430633M47738
PathwayREACTOME_SENSORY_PROCESSING_OF_SOUND

OTOF ACTB ACTG1 MYO15A

3.84e-0477634M41822
Pubmed

Identification of a novel actin isoform in hepatocellular carcinoma.

POTEE ACTBL2 ACTB ACTG1 ACTG2 POTEKP POTEI

6.17e-151596716824795
Pubmed

Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy.

POTEE IGHA2 ACTB ACTG1 ACTG2 POTEI

2.86e-079696623580065
Pubmed

Virus assembly and plasma membrane domains: which came first?

ACTB ACTG1 ACTG2

4.05e-07696322989508
Pubmed

HIV-1 protease cleaves actin during acute infection of human T-lymphocytes.

ACTB ACTG1 ACTG2

4.05e-0769631540415
Pubmed

HIV type 1 Gag and nucleocapsid proteins: cytoskeletal localization and effects on cell motility.

ACTB ACTG1 ACTG2

4.05e-07696311709093
Pubmed

Actin associates with the nucleocapsid domain of the human immunodeficiency virus Gag polyprotein.

ACTB ACTG1 ACTG2

4.05e-0769639971772
Pubmed

Tagging the human immunodeficiency virus gag protein with green fluorescent protein. Minimal evidence for colocalisation with actin.

ACTB ACTG1 ACTG2

4.05e-07696310049817
Pubmed

Human immunodeficiency virus nucleocapsid protein polymorphisms modulate the infectivity of RNA packaging mutants.

ACTB ACTG1 ACTG2

4.05e-07696312009869
Pubmed

HIV-1 Tat protein variants: critical role for the cysteine region in synaptodendritic injury.

ACTB ACTG1 ACTG2

4.05e-07696323811015
Pubmed

Retroviral assembly and budding occur through an actin-driven mechanism.

ACTB ACTG1 ACTG2

4.05e-07696319883584
Pubmed

Dynamic imaging of cell-free and cell-associated viral capture in mature dendritic cells.

ACTB ACTG1 ACTG2

4.05e-07696321917091
Pubmed

HIV-1 Gag protein associates with F-actin present in microfilaments.

ACTB ACTG1 ACTG2

4.05e-0769638661406
Pubmed

A protein ballet around the viral genome orchestrated by HIV-1 reverse transcriptase leads to an architectural switch: from nucleocapsid-condensed RNA to Vpr-bridged DNA.

ACTB ACTG1 ACTG2

4.05e-07696323017337
Pubmed

Interaction of the human immunodeficiency virus type 1 nucleocapsid with actin.

ACTB ACTG1 ACTG2

4.05e-07696310074138
Pubmed

Synaptodendritic recovery following HIV Tat exposure: neurorestoration by phytoestrogens.

ACTB ACTG1 ACTG2

4.05e-07696323875777
Pubmed

Establishment of a functional human immunodeficiency virus type 1 (HIV-1) reverse transcription complex involves the cytoskeleton.

ACTB ACTG1 ACTG2

4.05e-0769639841925
Pubmed

HIV-1 replication from after cell entry to the nuclear periphery.

ACTB ACTG1 ACTG2

7.08e-07796317504171
Pubmed

The PDZ-adaptor protein syntenin-1 regulates HIV-1 entry.

ACTB ACTG1 ACTG2

7.08e-07796322535526
Pubmed

siRNA and pharmacological inhibition of endocytic pathways to characterize the differential role of macropinocytosis and the actin cytoskeleton on cellular uptake of dextran and cationic cell penetrating peptides octaarginine (R8) and HIV-Tat.

ACTB ACTG1 ACTG2

7.08e-07796322465675
Pubmed

Selective targeting of ITK blocks multiple steps of HIV replication.

ACTB ACTG1 ACTG2

7.08e-07796318443296
Pubmed

The trinity of the cortical actin in the initiation of HIV-1 infection.

ACTB ACTG1 ACTG2

7.08e-07796322640593
Pubmed

PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.

KMT2D ACTBL2 EPC1 ACTB ACTG1

1.04e-066596522496869
Pubmed

Human immunodeficiency virus type 1 Tat regulates endothelial cell actin cytoskeletal dynamics through PAK1 activation and oxidant production.

ACTB ACTG1 ACTG2

1.13e-06896314694110
Pubmed

Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling.

ACTB ACTG1 ACTG2

1.13e-06896320147394
Pubmed

Interleukin 2-inducible T cell kinase (ITK) facilitates efficient egress of HIV-1 by coordinating Gag distribution and actin organization.

ACTB ACTG1 ACTG2

1.13e-06896323260110
Pubmed

Duplication and extensive remodeling shaped POTE family genes encoding proteins containing ankyrin repeat and coiled coil domains.

POTEE POTEKP POTEI

1.69e-06996316364570
Pubmed

Cytoskeletal proteins inside human immunodeficiency virus type 1 virions.

ACTB ACTG1 ACTG2

1.69e-0699638892894
Pubmed

Functional interaction between the cytoplasmic leucine-zipper domain of HIV-1 gp41 and p115-RhoGEF.

ACTB ACTG1 ACTG2

1.69e-06996310556093
Pubmed

HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells.

ACTB ACTG1 ACTG2

1.69e-06996318775311
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

DAB2IP SETD1B RPAP1 SYNE1 DOCK7 ANKRD12 MTCL1 BCL11A ADGRL3

1.99e-0640796912693553
Pubmed

Non-viral cellular substrates for human immunodeficiency virus type 1 protease.

ACTB ACTG1 ACTG2

2.41e-06109631991513
Pubmed

Gelsolin activity controls efficient early HIV-1 infection.

ACTB ACTG1 ACTG2

2.41e-061096323575248
Pubmed

Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus.

ACTB ACTG1 ACTG2

2.41e-06109631907279
Pubmed

A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs.

EPC1 ACTB ACTG1 ACTG2

2.67e-063596420946988
Pubmed

CAP2 deficiency delays myofibril actin cytoskeleton differentiation and disturbs skeletal muscle architecture and function.

ACTB ACTG1 ACTG2

3.31e-061196330962377
Pubmed

N-terminal Slit2 inhibits HIV-1 replication by regulating the actin cytoskeleton.

ACTB ACTG1 ACTG2

3.31e-061196323294842
Pubmed

Quantitative proteomic analysis of lentiviral vectors using 2-DE.

ACTB ACTG1 ACTG2

3.31e-061196319639585
Pubmed

Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.

POTEE IGHA2 ACTBL2 ACTB POTEI CEP164

3.77e-0614996622664934
Pubmed

HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Gα(i2) for degradation through ubiquitination.

ACTB ACTG1 ACTG2

4.40e-061296323071112
Pubmed

TGF-beta signaling is essential for joint morphogenesis.

NOG WNT9A SMAD2

5.71e-061396317576802
Pubmed

Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool.

TACC2 CEP164 NIN

5.71e-061396317920017
Pubmed

A QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics.

ACTBL2 ACTB ACTG1 ACTG2

6.19e-064396420876399
Pubmed

LIM kinase 1 - dependent cofilin 1 pathway and actin dynamics mediate nuclear retinoid receptor function in T lymphocytes.

ACTB ACTG1 ACTG2

7.26e-061496321923909
Pubmed

Regulating the functions of the HIV-1 matrix protein.

ACTB ACTG1 ACTG2

7.26e-061496317411366
Pubmed

Beta and gamma-cytoplasmic actins display distinct distribution and functional diversity.

ACTB ACTG1

7.54e-06296219638415
Pubmed

A single splice site mutation in human-specific ARHGAP11B causes basal progenitor amplification.

ARHGAP11A ARHGAP11B

7.54e-06296227957544
Pubmed

Beta- and gamma-cytoplasmic actins are required for meiosis in mouse oocytes.

ACTB ACTG1

7.54e-06296221778137
Pubmed

De novo mutations in the actin genes ACTB and ACTG1 cause Baraitser-Winter syndrome.

ACTB ACTG1

7.54e-06296222366783
Pubmed

Botulinum C2 toxin ADP-ribosylates cytoplasmic beta/gamma-actin in arginine 177.

ACTB ACTG1

7.54e-0629623335520
Pubmed

Association of human immunodeficiency virus Nef protein with actin is myristoylation dependent and influences its subcellular localization.

ACTB ACTG1

7.54e-0629629288906
Pubmed

High level expression of transfected beta- and gamma-actin genes differentially impacts on myoblast cytoarchitecture.

ACTB ACTG1

7.54e-0629621577857
Pubmed

Protooncogenic Role of ARHGAP11A and ARHGAP11B in Invasive Ductal Carcinoma: Two Promising Breast Cancer Biomarkers.

ARHGAP11A ARHGAP11B

7.54e-06296238046902
Pubmed

Prenatal presentation and diagnosis of Baraitser-Winter syndrome using exome sequencing.

ACTB ACTG1

7.54e-06296232588558
Pubmed

ARHGAP9 suppresses the migration and invasion of hepatocellular carcinoma cells through up-regulating FOXJ2/E-cadherin.

FOXJ2 ARHGAP9

7.54e-06296230206221
Pubmed

Baraitser-Winter cerebrofrontofacial syndrome.

ACTB ACTG1

7.54e-06296227625340
Pubmed

Baraitser-Winter Cerebrofrontofacial Syndrome

ACTB ACTG1

7.54e-06296226583190
Pubmed

Knockout of ACTB and ACTG1 with CRISPR/Cas9(D10A) Technique Shows that Non-Muscle β and γ Actin Are Not Equal in Relation to Human Melanoma Cells' Motility and Focal Adhesion Formation.

ACTB ACTG1

7.54e-06296232326615
Pubmed

Severe forms of Baraitser-Winter syndrome are caused by ACTB mutations rather than ACTG1 mutations.

ACTB ACTG1

7.54e-06296223756437
Pubmed

Cytochalasin D-induced actin gene expression in murine erythroleukemia cells.

ACTB ACTG1

7.54e-0629628482333
Pubmed

Isolation of cDNA clones for mouse cytoskeletal gamma-actin and differential expression of cytoskeletal actin mRNAs in mouse cells.

ACTB ACTG1

7.54e-0629623221869
Pubmed

Variants in genes encoding small GTPases and association with epithelial ovarian cancer susceptibility.

AKAP6 ARHGEF10L

7.54e-06296229979793
Pubmed

Impaired muscle relaxation and mitochondrial fission associated with genetic ablation of cytoplasmic actin isoforms.

ACTB ACTG1

7.54e-06296229265728
Pubmed

Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia.

ACTB ACTG1

7.54e-06296222246323
Pubmed

Structure, chromosome location, and expression of the human gamma-actin gene: differential evolution, location, and expression of the cytoskeletal beta- and gamma-actin genes.

ACTB ACTG1

7.54e-0629622837653
Pubmed

Prevalence of Cytoplasmic Actin Mutations in Diffuse Large B-Cell Lymphoma and Multiple Myeloma: A Functional Assessment Based on Actin Three-Dimensional Structures.

ACTB ACTG1

7.54e-06296232349449
Pubmed

Baraitser-Winter cerebrofrontofacial syndrome: Report of two adult siblings.

ACTB ACTG1

7.54e-06296232506774
Pubmed

Identification and developmental expression of a smooth-muscle gamma-actin in postmeiotic male germ cells of mice.

ACTG1 ACTG2

7.54e-0629622747639
Pubmed

Differential arginylation of actin isoforms is regulated by coding sequence-dependent degradation.

ACTB ACTG1

7.54e-06296220847274
Pubmed

Measurements of spatiotemporal changes in G-actin concentration reveal its effect on stimulus-induced actin assembly and lamellipodium extension.

ACTB ACTG1

7.54e-06296221502360
Pubmed

The evolution and complexity of the genes encoding the cytoskeletal proteins of human epidermal cells.

ACTB ACTG1

7.54e-0629626686106
Pubmed

Actin amino-acid sequences. Comparison of actins from calf thymus, bovine brain, and SV40-transformed mouse 3T3 cells with rabbit skeletal muscle actin.

ACTB ACTG1

7.54e-062962213279
Pubmed

The First Korean Case of Baraitser-Winter Cerebro-Fronto-Facial Syndrome with a Novel Mutation in ACTB Diagnosed Via Targeted Gene Panel Sequencing and Literature Review.

ACTB ACTG1

7.54e-06296233334799
Pubmed

ArhGAP11A mediates amyloid-β generation and neuropathology in an Alzheimer's disease-like mouse model.

ARHGAP11A ARHGAP11B

7.54e-06296237302068
Pubmed

Loss-of-function mutations in MYO15A and OTOF cause non-syndromic hearing loss in two Yemeni families.

OTOF MYO15A

7.54e-06296237189200
Pubmed

Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine/isoleucine zippers.

AKAP6 RYR2

7.54e-06296211352932
Pubmed

β-Actin specifically controls cell growth, migration, and the G-actin pool.

ACTB ACTG1

7.54e-06296221900491
Pubmed

The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma.

POTEE DSC3 ACTB ACTG1 POTEKP

8.83e-0610096521800051
Pubmed

LINC00941 promotes pancreatic cancer malignancy by interacting with ANXA2 and suppressing NEDD4L-mediated degradation of ANXA2.

ACTBL2 ACTG1 AHNAK2

9.05e-061596335977942
Pubmed

14-3-3ζ negatively regulates mitochondrial biogenesis in GBM residual cells.

DSC3 IGHA2 ACTG1 POTEKP

1.05e-054996434825085
Pubmed

Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.

POTEE ACTBL2 ACTB ACTG1 ACTG2 POTEKP POTEI

1.07e-0527196732433965
Pubmed

Requirement for an intact T-cell actin and tubulin cytoskeleton for efficient assembly and spread of human immunodeficiency virus type 1.

ACTB ACTG1 ACTG2

1.35e-051796317360745
Pubmed

The cleavage of host cell proteins by HIV-1 protease.

ACTB ACTG1 ACTG2

1.35e-05179638997639
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

DAB2IP GPHN CACNA1E LSG1 SYNE1 ACTB DOCK7 DGKI MTCL1 BCL11A PARD3 MAPK8IP2

1.40e-05963961228671696
Pubmed

Molecular characterization of abLIM, a novel actin-binding and double zinc finger protein.

ACTB ACTG1

2.26e-0539629245787
Pubmed

Not just scaffolding: plectin regulates actin dynamics in cultured cells.

ACTG1 ACTG2

2.26e-0539629808630
Pubmed

Impact of altered actin gene expression on vinculin, talin, cell spreading, and motility.

ACTB ACTG1

2.26e-0539627646816
Pubmed

Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL.

ACTB ACTG1

2.26e-05396219008859
Pubmed

Angiostatin and plasminogen share binding to endothelial cell surface actin.

ACTB ACTG1

2.26e-05396215746964
Pubmed

Interaction of Receptor-Binding Domain of the SARS-CoV-2 Omicron Variant with hACE2 and Actin.

ACTB ACTG1

2.26e-05396239195208
Pubmed

Identification of novel variants in MYO15A, OTOF, and RDX with hearing loss by next-generation sequencing.

OTOF MYO15A

2.26e-05396231250571
Pubmed

Actin Is Crucial for All Kinetically Distinguishable Forms of Endocytosis at Synapses.

ACTB ACTG1

2.26e-05396227840001
Pubmed

Restricted morphological and behavioral abnormalities following ablation of β-actin in the brain.

ACTB ACTG1

2.26e-05396222403730
Pubmed

Functional molecular complexes of human N-formyl chemoattractant receptors and actin.

ACTB ACTG1

2.26e-0539628228254
Pubmed

CTGF/Hcs24 interacts with the cytoskeletal protein actin in chondrocytes.

ACTB ACTG1

2.26e-05396212470643
Pubmed

RNA polymerase II accumulation in the promoter-proximal region of the dihydrofolate reductase and gamma-actin genes.

ACTG1 ACTG2

2.26e-05396212612070
Pubmed

RNA helicase A acts as a bridging factor linking nuclear beta-actin with RNA polymerase II.

ACTB DHX9

2.26e-05396219309309
Pubmed

Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed.

ACTB ACTG1

2.26e-0539626865942
Pubmed

Mutation analysis of the short cytoplasmic domain of the cell-cell adhesion molecule CEACAM1 identifies residues that orchestrate actin binding and lumen formation.

ACTB ACTG1

2.26e-05396217192268
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

DAB2IP LLGL2 SLC4A7 DSC3 MAP4K3 PHACTR4 PARD3 SMAD2

2.26e-0542196836976175
Pubmed

Modifications in the human T cell proteome induced by intracellular HIV-1 Tat protein expression.

ACTB ACTG1 ACTG2

3.02e-052296316526095
InteractionACTG2 interactions

POTEE ACTBL2 ACTB ACTG1 ACTG2 POTEI

1.11e-0749956int:ACTG2
InteractionPOTEJ interactions

POTEE ACTBL2 ACTB ACTG1 ACTG2 POTEI

1.60e-0752956int:POTEJ
InteractionPOTEI interactions

POTEE ACTBL2 ACTB ACTG1 ACTG2 C1QTNF1 POTEI

6.46e-07105957int:POTEI
InteractionERRFI1 interactions

POTEE ACTBL2 ACTB ACTG1 ACTG2 POTEKP MFSD5

7.34e-07107957int:ERRFI1
InteractionTWF2 interactions

ACTBL2 ACTB CCDC87 ACTG1 UBXN1 DHX9

7.81e-06100956int:TWF2
InteractionPHACTR2 interactions

ACTBL2 ACTB ACTG1 POTEI

1.01e-0529954int:PHACTR2
InteractionHSD17B3 interactions

ACTBL2 ACTB POTEI SMAD2

1.01e-0529954int:HSD17B3
InteractionWASH8P interactions

ACTBL2 ACTB POTEKP

1.63e-0511953int:WASH8P
InteractionARHGAP12 interactions

PRR12 ACTBL2 PHACTR4 ACTB ACTG1

1.73e-0568955int:ARHGAP12
InteractionRNASE3 interactions

ACTBL2 ACTB POTEI

3.56e-0514953int:RNASE3
InteractionPOTEE interactions

POTEE ACTBL2 ACTB ACTG1 ACTG2 POTEI

4.13e-05134956int:POTEE
InteractionNAA80 interactions

ACTBL2 ACTB POTEKP

4.43e-0515953int:NAA80
InteractionGSN interactions

PIK3CG ACTBL2 ACTB ACTG1 TEX14 POTEI ARHGAP11A

6.52e-05212957int:GSN
InteractionMAGEA10 interactions

FOXJ2 ACTBL2 ACTB MTCL1

9.04e-0550954int:MAGEA10
InteractionLRRC20 interactions

ACTBL2 ACTB POTEI

9.31e-0519953int:LRRC20
InteractionRLIM interactions

TXNIP ACTBL2 ACTB APBA2 DOCK7 UBXN1 POTEI ARHGAP11A DHX9

9.78e-05392959int:RLIM
InteractionUCHL5 interactions

POTEE DSC3 ACTB ACTG1 E2F2 POTEKP RIPK4 SMAD2

1.33e-04319958int:UCHL5
InteractionRHOT2 interactions

LSG1 SYNE1 EXD2 TACC2 RIPK4 AHNAK2 DHX9 RAVER1

1.39e-04321958int:RHOT2
InteractionGATAD2B interactions

FOXJ2 GPHN TXNIP ACTB ACTG1 BCL11A SMAD2

1.60e-04245957int:GATAD2B
InteractionSCIN interactions

ACTBL2 ACTB ACTG1 POTEI

1.62e-0458954int:SCIN
InteractionTWF1 interactions

IGHA2 ACTB CCDC87 ACTG1 UBXN1 ARHGAP11A

1.64e-04172956int:TWF1
InteractionDEFA6 interactions

POTEE ACTBL2 ACTB

1.68e-0423953int:DEFA6
InteractionPHACTR4 interactions

LLGL2 PHACTR4 ACTB ACTG1 PARD3

1.73e-04110955int:PHACTR4
InteractionKAT14 interactions

CCT8L2 SETD1B ACTBL2 ACTB ACTG1

1.89e-04112955int:KAT14
InteractionGC interactions

ACTBL2 ACTB POTEKP POTEI

2.10e-0462954int:GC
Cytoband2q21.1

POTEE POTEKP POTEI

2.52e-04589632q21.1
Cytoband18p11.22

ANKRD12 MTCL1

5.77e-041796218p11.22
Cytoband15q13.2

ARHGAP11A ARHGAP11B

8.85e-042196215q13.2
CytobandEnsembl 112 genes in cytogenetic band chr15q13

APBA2 ARHGAP11A ARHGAP11B

1.24e-03100963chr15q13
Cytoband8q24.3

ZFP41 ZNF623 DENND3

1.76e-031139638q24.3
GeneFamilyActins

ACTB ACTG1 ACTG2

8.40e-076643929
GeneFamilyAnkyrin repeat domain containing|POTE ankyrin domain containing

POTEE POTEKP POTEI

1.18e-0513643685
GeneFamilyRho GTPase activating proteins|BCH domain containing

ARHGAP9 ARHGAP11A ARHGAP11B

7.36e-0450643721
GeneFamilyUBX domain containing

ASPSCR1 UBXN1

9.38e-0413642364
GeneFamilyAnkyrin repeat domain containing

POTEE DGKI ANKRD12 RIPK4 POTEI

1.65e-03242645403
GeneFamilyPDZ domain containing

MAST4 APBA2 PARD3 AHNAK2

2.06e-031526441220
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

KMT2D SETD1B

6.43e-0334642487
GeneFamilyActins|Deafness associated genes

OTOF ACTG1 MYO15A

7.51e-031136431152
GeneFamilyEF-hand domain containing

CACNA1E KCNIP2 RYR2 NIN

7.55e-03219644863
ToppCell15-Airway-Mesenchymal-Airway_Smooth_Muscle|Airway / Age, Tissue, Lineage and Cell class

AKAP6 POTEE ACTB ACTG2 TACC2 MTCL1 PPP1R1A

7.11e-08165967531804467601e1ee1f771cffa21501f6d464ae10
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AKAP6 ACTB ACTG2 MTCL1 ISM2 AHNAK2 PPP1R1A

1.67e-071879673912bbb610a4a84791e9bda92a2d57a52c31d29e
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

NOG ASIC2 ACTG2 TACC2 MTCL1 BCL11A PPP1R1A

1.73e-07188967f54b063025d80de631382bf5326bc40aab7f7d00
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

NOG ACTG2 C1QTNF1 TACC2 MTCL1 BCL11A PPP1R1A

1.86e-07190967938d1f66094b1c94606e0d40213a39e5112f3322
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AKAP6 NOG ACTB ACTG2 MTCL1 AHNAK2 PPP1R1A

2.07e-07193967173f1d83133f5ffa88e2a75d28835ad7acd2aa90
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

AKAP6 WNT9A ACTB ACTG2 MTCL1 BCL11A PPP1R1A

2.14e-0719496793bc72a933ccc6a760e5353f072afb606571c6fc
ToppCellnucseq-Epithelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GPHN LLGL2 MAST4 SYNE1 TACC2 PARD3 C8orf34

2.22e-071959679406866f99555198a9be311fbd65751b70f35446
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 SYNE1 ACTB ACTG2 C1QTNF1 ADGRL3 RYR2

2.46e-07198967c12e7511628db819a52959bb68580e27c00c2e41
ToppCellLPS_only-Mesenchymal_myocytic|LPS_only / Treatment groups by lineage, cell group, cell type

AKAP6 SLC4A7 SYNE1 ACTG2 C1QTNF1 TACC2 RYR2

2.63e-072009678bc9923f82bfb836e2f524204c92050edeae8ca5
ToppCell3'-Child09-12-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FAM178B CCDC87 ACTG2 C1QTNF1 C8orf34 PPP1R1A

2.35e-06177966d731400997afea379f47ae8aa0f82802962b0861
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-ACTC+_SMC|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

ACTB ACTG2 MTCL1 ISM2 AHNAK2 PPP1R1A

2.95e-0618496639168ca2bbf1369c9fe87c67f0aaff5e3cd03151
ToppCellILEUM-inflamed-(8)_Fibroblast-(8)_Smooth_muscle_cells|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

TXNIP FAM163A ACTG2 ADGRL3 MAPK8IP2 AHNAK2

3.13e-06186966cacc2f0b2ed46516173b61ba1c5c226a2db7cddc
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1E OTOF POU2F2 C8orf34 RYR2 PPP1R1A

3.13e-061869667278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCellLA-13._Vascular_Smooth_Muscle|LA / Chamber and Cluster_Paper

AKAP6 NBEAL1 ACTG2 C8orf34 ADGRL3 RYR2

3.33e-0618896634e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

AKAP6 WNT9A ACTG2 TACC2 MTCL1 RYR2

3.33e-06188966293f2fa99f5f96aa7fd2b2a5cc94ff60eeaabe11
ToppCellRV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

AKAP6 TXNIP MAST4 TACC2 BCL11A RYR2

3.44e-061899665e80c47f63980904c4c1ff02c201b67b456a0974
ToppCellLA-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

AKAP6 NBEAL1 ACTG2 C8orf34 ADGRL3 ARHGEF10L

3.44e-061899666b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-bronchial_smooth_muscle_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOG DSC3 ASIC2 ACTG2 TACC2 PHLPP2

3.44e-061899664dc32b463546bbe7250dddd281b92ad17ec22da1
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-Airway_Smooth_Muscle|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOG DSC3 ASIC2 ACTG2 TACC2 PHLPP2

3.44e-061899660d06bf0d7191d13a1c4f30a7881e7ea1093bfd6f
ToppCellControl-Stromal-SMC|Stromal / Disease state, Lineage and Cell class

AKAP6 ACTB ACTG2 C1QTNF1 DENND3 ADGRL3

3.65e-061919662da83c493e60ad0278848957645277d76737a188
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NOG ACTB ACTG2 MTCL1 AHNAK2 PPP1R1A

3.88e-061939664aa976b596830b585e8d9c808d5072ed23d13a7c
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GPHN MAST4 SYNE1 TACC2 PARD3 C8orf34

3.88e-06193966fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GPHN LLGL2 MAST4 TACC2 PARD3 ARHGEF10L

3.88e-061939663866667dd221612589ae50f5c52f73a183a49ce6
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NOG ACTB ACTG2 MTCL1 AHNAK2 PPP1R1A

3.88e-061939665578f7cb3ec68c9a38cc5304b618b81283024d5e
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TXNIP ACTB ACTG2 MTCL1 AHNAK2 PPP1R1A

3.88e-06193966b1893193766ae41bf2ab6ed4083285c9c814e608
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GPHN MAST4 SYNE1 TACC2 PARD3 C8orf34

3.88e-06193966f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-B_lymphocytic-memory_B_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TXNIP IGHA2 NBEAL1 POU2F2 BCL11A DENND3

3.99e-06194966f0c113edb706d53792892115b67277a285219942
ToppCellIPF-Multiplet-Multiplet|IPF / Disease state, Lineage and Cell class

MAST4 CFAP73 SYNE1 TACC2 PARD3 C8orf34

4.11e-06195966fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCellIPF-Multiplet|IPF / Disease state, Lineage and Cell class

MAST4 CFAP73 SYNE1 TACC2 PARD3 C8orf34

4.11e-06195966eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NOG ACTB ACTG2 MTCL1 AHNAK2 PPP1R1A

4.36e-06197966ba6393671a980a1d439307601d18db70a1b1e1f3
ToppCellTracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 SYNE1 ACTB ACTG2 ADGRL3 RYR2

4.36e-06197966ac4f53acb2f8a428b0f2fab3c30a34e095a1bed7
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

NOG ACTB ACTG2 C1QTNF1 TACC2 MTCL1

4.49e-06198966637f11e292b90d86cdc0d0d828eb26f38289c25b
ToppCellParenchymal-NucSeq-Stromal-Myofibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 ACTG2 C1QTNF1 ADGRL3 RYR2 ARHGEF10L

4.49e-06198966bd42c03e384e64f61b02618cf1a5440033bb04b2
ToppCellParenchymal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_pulmonary|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AKAP6 ACTG2 C1QTNF1 ADGRL3 RYR2 ARHGEF10L

4.62e-06199966b1753474152b82a0b811b9878c890a359e14919a
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Pericyte-Pericyte_3|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

AKAP6 SYNE1 ACTG2 C1QTNF1 TACC2 RYR2

4.76e-062009669169a9ec8e9ab95d90a64c5a19ac666a5cf82313
ToppCellLPS_only-Mesenchymal_myocytic-Pericyte|LPS_only / Treatment groups by lineage, cell group, cell type

AKAP6 NBEAL1 SYNE1 ACTG2 C1QTNF1 RYR2

4.76e-062009668c8ef2b19ab5b1bfc0fae6c38a330f464f28e86f
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

AKAP6 SLC4A7 SYNE1 ACTG2 TACC2 MTCL1

4.76e-06200966dcdaec3ca3a3024dc1b8788c417003f84c2bffdc
ToppCellLPS_only-Mesenchymal_myocytic-Pericyte-Pericyte_3|LPS_only / Treatment groups by lineage, cell group, cell type

AKAP6 SYNE1 ACTG2 C1QTNF1 TACC2 RYR2

4.76e-062009667c62678cf408aaaf98d6df0fb27814d2007c4521
ToppCellE18.5-samps-Epithelial-Alveolar_epithelial-Uncommitted_AE_Progenitor|E18.5-samps / Age Group, Lineage, Cell class and subclass

VSIG10L TACC2 RIPK4 TREML1 MSLN

7.05e-061239655f002f5180fe47fe57ab888b5f0319df99ab2c59
ToppCellsevere-unassigned|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

CACNA1E DGKI E2F2 DENND3 RAVER1

8.56e-06128965bef9cf0078fa8498d63f0723f1fa4a3c92405e10
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

OTOF ACTG2 DGKI RYR2 PPP1R1A

3.36e-05170965cb1ed6bd409ee1cf11be0d5e7cdcffe2ab220d38
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

OTOF ACTG2 DGKI RYR2 PPP1R1A

3.36e-05170965da4fb1e186e9bec6bba0b25f2a0e68f9e11c6017
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

AKAP6 ACTG2 ADGRL3 RYR2 ARHGEF10L

3.65e-05173965cb6389536195443633adb06e5f1b7483530773d1
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AKAP6 CACNA1E OTOF ACTG2 TEX14

3.76e-05174965c529f3674b784f872f4387ffdeb46aecb619976b
ToppCellControl-B_cells|Control / group, cell type (main and fine annotations)

TXNIP IGHA2 PIK3CG POU2F2 BCL11A

3.97e-051769659125caa27bf790f6b1b960a86c09b4bcb1b58641
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

OTOF WNT9A ACTG2 CCT8L1P PPP1R1A

4.07e-051779657ebdcedfe02da6d05bba3d625d8bd4c4ea96e4ad
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-Plasma_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

IGHA2 PIK3CG POU2F2 E2F2 TEX14

4.19e-05178965f815bc76f98aaea2d9058173b02b6f36e45283ce
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-Plasma_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

IGHA2 PIK3CG POU2F2 E2F2 TEX14

4.19e-05178965a0334764e865fea652c54b94bbc3b173f7cbc9fc
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ACTB ACTG2 MTCL1 ISM2 PPP1R1A

4.30e-05179965e860dca9b28ac5af61804bfd729cd39257cdb352
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

LLGL2 TACC2 RIPK4 MTCL1 DENND3

4.30e-0517996504ce3673e46606f63d9c87bcba3a64c96817d812
ToppCellControl-Epithelial_cells-AT2|Control / group, cell type (main and fine annotations)

GPHN MAST4 SYNE1 TACC2 C8orf34

4.41e-05180965198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCellControl-Fibroblasts-Airway_smooth_muscle|Control / group, cell type (main and fine annotations)

AKAP6 ACTG2 C1QTNF1 ADGRL3 RYR2

4.41e-05180965d0de12749ef0f51f0931c6e7b9b99966bdbc3ec1
ToppCellCOPD-Epithelial-Mesothelial|World / Disease state, Lineage and Cell class

MAST4 DSC3 WNT9A C1QTNF1 MSLN

5.03e-0518596523579988036fc1925992c31919750f9b3fe9f790
ToppCellLV-15._Ventricular_Cardiomyocyte_III|World / Chamber and Cluster_Paper

AKAP6 MAST4 TACC2 BCL11A RYR2

5.03e-051859656baccb26f999145e51b91d94315bf8d4655bef31
ToppCellCOVID-19-lung-Plasma_cells_PRDM1/BLIMP_hi|lung / Disease (COVID-19 only), tissue and cell type

IGHA2 PIK3CG POU2F2 E2F2 ARHGAP11A

5.16e-0518696566676d9395172de5707e204826a1c9f73b448cca
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

AKAP6 SYNE1 ACTG2 C1QTNF1 RYR2

5.16e-051869654780af76237d7af2abbe2d8d5530cdf53e3ed0b7
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

NOG ASIC2 ACTG2 ASPSCR1 MTCL1

5.29e-05187965387cb27c8a20031cd87381a9e1172f1f62e1488b
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

NOG ACTB ACTG2 MTCL1 AHNAK2

5.43e-0518896574f7d216209cabdc96b2d46685b0ae017fdcc8fc
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-T_lymphocytic_-_developing-thymocyte|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TXNIP EPC1 ACTB ACTG1 PARD3

5.43e-05188965bcfc426b60d8e5a23a2360bfb68b32868fec9fbf
ToppCellCOVID-19-Epithelial_cells|COVID-19 / group, cell type (main and fine annotations)

LLGL2 MAST4 TACC2 PARD3 C8orf34

5.43e-05188965c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCellCOPD-Stromal-SMC|Stromal / Disease state, Lineage and Cell class

AKAP6 ACTB ACTG2 C1QTNF1 ADGRL3

5.43e-051889659ffef4b01d0ddd6913c9ed6be79aeaaabd5e41ed
ToppCellCOPD-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

MAST4 SYNE1 APBA2 TACC2 PARD3

5.43e-05188965186fe1ea328c942910190a4240262c0d8642ea3b
ToppCellControl-Epithelial_cells|Control / group, cell type (main and fine annotations)

MAST4 NBEAL1 TACC2 PARD3 C8orf34

5.43e-05188965707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCellCOVID-19-lung-Plasma_cells_PRDM1/BLIMP_hi|COVID-19 / Disease (COVID-19 only), tissue and cell type

IGHA2 PIK3CG POU2F2 E2F2 ARHGAP11A

5.43e-05188965567b08514d9d84cbb40f9b7a679eec304f023428
ToppCellCOPD-Epithelial-Mesothelial|COPD / Disease state, Lineage and Cell class

MAST4 WNT9A C1QTNF1 PARD3 MSLN

5.56e-0518996579bb2593ad5d17f94b17972884241f03a0f43770
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_myocytic|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

NOG ACTB ACTG2 MTCL1 AHNAK2

5.56e-05189965b6d5dec55bf352f6ae19d8f488ae70aa10fb9a8f
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Neuron|GW09 / Sample Type, Dataset, Time_group, and Cell type.

AKAP6 ACTB ACTG1 ACTG2 POU2F2

5.56e-051899653717d1148e26ac78a26aea0ca1dbfbb9d3668877
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ASIC2 DGKI BCL11A RYR2 NIN

5.56e-05189965a75226616340045b581d08429d2e123e041dee55
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

NOG ACTG2 TACC2 MTCL1 AHNAK2

5.56e-05189965da9ecc0d7b81c1901f30f97bb44112dc85444a66
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

NOG ASIC2 ACTG2 ASPSCR1 MTCL1

5.56e-051899650abc7a4900cc9033bc1be69b770ccc54a6bf41b4
ToppCellIPF-Epithelial-Basal|IPF / Disease state, Lineage and Cell class

MAST4 DSC3 TACC2 RIPK4 PARD3

5.70e-05190965ea19e9ce954f2dfde97388db9695325cd92ab88f
ToppCellPCW_05-06-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

AKAP6 FAM163A MAPK8IP2 PPP1R1A TG

5.85e-051919653a5081dc542ac6262acfe5f8084a86616fee8082
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2|Children_(3_yrs) / Lineage, Cell type, age group and donor

GPHN MAST4 TACC2 PARD3 C8orf34

5.85e-05191965a0332a4ef629510fb313ec119195c44a3f704a80
ToppCellLA-03._Atrial_Cardiomyocyte|LA / Chamber and Cluster_Paper

AKAP6 CACNA1E MAST4 TACC2 RYR2

5.85e-051919655d1b674eb7703830b7ce8bbeac3363cabd0e6ae9
ToppCellEpithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|World / Lineage, Cell type, age group and donor

LLGL2 MAST4 NBEAL1 PARD3 C8orf34

5.85e-05191965d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCellEpithelial|World / Lineage, Cell type, age group and donor

LLGL2 MAST4 TACC2 PARD3 C8orf34

5.99e-05192965499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCellCOPD-Epithelial|COPD / Disease state, Lineage and Cell class

MAST4 CFAP73 TACC2 PARD3 C8orf34

5.99e-051929650644fad5df18f0021f6f49cca996d8cf47f972ff
ToppCellH1299-infected|H1299 / Cell line, Condition and Strain

CDK5RAP3 PHACTR4 DDX51 ANKRD12 AHNAK2

5.99e-051929659cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCellIPF-Stromal-SMC|Stromal / Disease state, Lineage and Cell class

AKAP6 ACTB ACTG2 C1QTNF1 ADGRL3

5.99e-051929659b06c7336624ef21f8e5393725b56038a8028e57
ToppCellAdult-Epithelial|Adult / Lineage, Cell type, age group and donor

LLGL2 MAST4 TACC2 PARD3 C8orf34

5.99e-05192965efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCell368C-Fibroblasts-Fibroblast-K_(Pericytes)|368C / Donor, Lineage, Cell class and subclass (all cells)

AKAP6 ACTG2 C8orf34 ADGRL3 PPP1R1A

6.14e-051939655182284dfa7c94027e94172e08f78c86b95d63f4
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1E OTOF C8orf34 RYR2 PPP1R1A

6.14e-05193965be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCell368C-Fibroblasts-Fibroblast-K_(Pericytes)|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

AKAP6 ACTG2 C8orf34 ADGRL3 PPP1R1A

6.14e-051939655260ac95a15cc43a19909badad0c7e3854da920d
ToppCell368C-Fibroblasts-Fibroblast-K_(Pericytes)-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

AKAP6 ACTG2 C8orf34 ADGRL3 PPP1R1A

6.14e-051939655ec917931b438dd0e7fb03eb6af459d3ef6b84ba
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1E OTOF C8orf34 RYR2 PPP1R1A

6.14e-051939650c652ebe22ce5d2927599dd97ef1920547858395
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1E OTOF C8orf34 RYR2 PPP1R1A

6.14e-051939658689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCell368C-Fibroblasts-Fibroblast-K_(Pericytes)-|368C / Donor, Lineage, Cell class and subclass (all cells)

AKAP6 ACTG2 C8orf34 ADGRL3 PPP1R1A

6.14e-051939654f7bab0115469c855160636d168bd6e5d4e2dd2f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

GPHN LLGL2 MAST4 PHACTR4 PARD3

6.30e-051949657002937e8903e037332a215d00fbc7c7843b33f2
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NOG ACTB ACTG2 MTCL1 AHNAK2

6.30e-0519496512a2c60303607b8b5812405ad216d0612c56c64b
ToppCellnucseq-Epithelial-Epithelial_Alveolar|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GPHN MAST4 SYNE1 TACC2 PARD3

6.30e-0519496553f3e49e91b1096f3226010e2de767efb490dfe4
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ACTB ACTG2 MTCL1 AHNAK2 PPP1R1A

6.30e-05194965bea369e9a7018d862e4d7f1c9ec2de50f3fd38ec
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-myocytic|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NOG ACTB ACTG2 MTCL1 AHNAK2

6.30e-0519496515060cc25baf49dd04d9c20499e28718610ef754
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

GPHN MAST4 SYNE1 TACC2 PARD3

6.30e-0519496597534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_neuro-secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FAM163A OTOF DGKI POTEI ADGRL3

6.30e-051949652dcc3b99dbedaf8a6916891c85091ddb79d7ee31
ToppCellCOVID-19-lung-Pericytes/_Smooth_Muscle|lung / Disease (COVID-19 only), tissue and cell type

AKAP6 ACTG2 C1QTNF1 ADGRL3 RYR2

6.30e-051949655e1e0513a54ec4cf0b247ec85c9fbc68dfac1da3
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-MYL4+_SMC|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

NOG ACTB ACTG2 MTCL1 AHNAK2

6.45e-05195965dba2a87efd7e067c094c4b367feb4138cab62735
ToppCellControl-Multiplet|Control / Disease state, Lineage and Cell class

MAST4 SYNE1 TACC2 PARD3 C8orf34

6.45e-05195965618900c80bea09d46dad3f741bd1bff8bf0a64ee
ToppCellIPF-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

MAST4 CFAP73 TACC2 PARD3 C8orf34

6.45e-0519596521dbdc803c6947024dc2416e9e21c2ef0af9bc31
ToppCellE12.5-Mesenchymal-myocytic_cell-aortic_smooth_muscle_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NOG ACTB ACTG2 MTCL1 PPP1R1A

6.45e-05195965bff7685784688425bebd78b0f284a6d4475a9415
ToppCellE12.5-Mesenchymal-myocytic_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

NOG ACTB ACTG2 MTCL1 PPP1R1A

6.45e-05195965aed243418cdb5df4563a7b935c1ecbd744590901
DrugNsc687160

ACTL7B ACTBL2 ACTB ACTG1 ACTG2

8.85e-0918945CID005459290
Drugtolytoxin

ACTL7B ACTBL2 ACTB ACTG1 ACTG2

1.20e-0819945CID006440827
DrugNSC312786

ACTL7B ACTBL2 ACTB ACTG1 ACTG2

2.08e-0821945CID000329495
DrugAC1L8NVR

ACTL7B ACTBL2 ACTB ACTG1 ACTG2

2.08e-0821945CID000384633
DrugAC1Q6LQU

ACTL7B ACTBL2 ACTB ACTG1 ACTG2 RIPK4

4.50e-0848946CID000072380
Drugplakin

ACTL7B DSC3 SYNE1 ACTBL2 ACTB ACTG1 ACTG2

4.82e-0882947CID000018752
Drugmanidipine

ACTL7B CACNA1E ACTBL2 ACTB ACTG1 ACTG2 RYR2

1.34e-0795947CID000004008
Drugazaspiracid

ACTL7B ACTBL2 ACTB ACTG1 ACTG2

1.41e-0730945CID006451158
DrugAC1L1HS4

ACTL7B ACTBL2 ACTB ACTG1 ACTG2

1.99e-0732945CID000004267
DrugN,N'-p-phenylenedimaleimide

ACTL7B ACTBL2 ACTB ACTG1 ACTG2

2.73e-0734945CID000076765
Drug1,N6-ethenoadenosine 5'-diphosphate

ACTL7B ACTBL2 ACTB ACTG1 ACTG2

2.73e-0734945CID000001312
DrugNSC107658

ACTL7B SLC4A7 SLC2A6 ACTBL2 ACTB ACTG1 ACTG2 MYO15A MSLN TG

5.54e-073069410CID000002919
DrugB0683

ACTL7B CLN3 ACTBL2 ACTB ACTG1 ACTG2 MYO15A

5.59e-07117947CID006398969
Drugepsilon-ATP

ACTL7B ACTBL2 ACTB ACTG1 ACTG2

7.18e-0741945CID000162262
Drugm2-19

ACTL7B ACTB ACTG1 ACTG2

1.01e-0619944CID000079129
DrugAC1L8FNU

ACTL7B ACTBL2 ACTB ACTG1 ACTG2

1.03e-0644945CID000425429
DrugNpCaM

ACTL7B ACTBL2 ACTB ACTG1 ACTG2

1.60e-0648945CID000122259
DrugmDia

ACTL7B GPHN ACTBL2 ACTB ACTG1 ACTG2

2.41e-0693946CID000128346
Drug3-methylhistidine

ACTL7B ACTBL2 ACTB ACTG1 ACTG2

3.18e-0655945CID000064969
Drugdihydrocytochalasin B

ACTL7B ACTBL2 ACTB ACTG1 ACTG2

4.15e-0658945CID000003064
Drugberyllium fluoride

ACTL7B CLN3 ACTBL2 ACTB ACTG1 ACTG2

4.37e-06103946CID000024589
DrugCID5288653

ACTL7B ACTB ACTG1 ACTG2

5.17e-0628944CID005288653
Drugoryzalin

ACTL7B ACTBL2 ACTB ACTG1 ACTG2

6.27e-0663945CID000029393
Drugirinotecan HCl; Down 200; 100uM; PC3; HT_HG-U133A

GPHN MAST4 MAP4K3 TACC2 ANKRD12 MTCL1 PARD3

7.05e-061719477535_DN
DrugAC1L1BDQ

ACTL7B ASIC2 ACTBL2 ACTB ACTG1 ACTG2 DGKI

7.60e-06173947CID000001394
Drug5-IAF

ACTL7B ACTBL2 ACTB ACTG1 ACTG2

7.89e-0666945CID000123822
Drugblebbistatin

ACTL7B ACTBL2 ACTB ACTG1 ACTG2 MYO15A

8.68e-06116946CID003476986
DrugAC1L1ERT

ACTL7B ACTBL2 ACTB ACTG1 ACTG2

9.83e-0669945CID000002920
Drugcaged ATP

ACTL7B ACTBL2 ACTB ACTG1 ACTG2

1.05e-0570945CID000123806
Drugbistheonellide A

ACTBL2 ACTB ACTG1

1.10e-0511943CID006441172
DrugViroisin

ACTBL2 ACTB ACTG1

1.10e-0511943CID000119538
DrugAC1NSKFN

ACTL7B ACTB ACTG1 ACTG2

1.45e-0536944CID005311324
Drug2C5P

ACTL7B ACTB ACTG1 ACTG2 MSLN TG

1.46e-05127946CID000447961
DrugBFDGE

ACTBL2 ACTB ACTG1

1.46e-0512943CID000091511
Drugmicrocystin-LR

ACTL7B ACTBL2 ACTB ACTG1 ACTG2 PPP1R1A

1.59e-05129946CID000445433
DrugAC1LADJ6

ACTL7B ACTBL2 EPC1 ACTB ACTG1 ACTG2

1.67e-05130946CID000486032
Drugsulfenosine

SYNE1 ARHGAP9

1.69e-052942CID000129862
Drugsulfonosine

SYNE1 ARHGAP9

1.69e-052942CID000129864
DrugAC1L9EF8

ACTL7B ACTBL2 ACTB ACTG1 ACTG2

1.91e-0579945CID000443315
DrugAC1OAGGW

ACTL7B ACTBL2 ACTB ACTG1 ACTG2 DGKI TG

2.15e-05203947CID006857364
Drugkabiramide C

ACTBL2 ACTB ACTG1

2.40e-0514943CID005288658
Drugformamide

ACTL7B ACTBL2 ACTB ACTG1 ACTG2

2.72e-0585945CID000000713
DrugD-myo-inositol 1,4-bisphosphate

ACTL7B ACTBL2 ACTB ACTG1 ACTG2

2.88e-0586945CID000000805
Drugpolyproline

ACTL7B ACTBL2 ACTB ACTG1 ACTG2 RIPK4 TREML1 MAPK8IP2

3.07e-05295948CID000439587
DrugCompound 1-4

GPHN NOG SYNE1 ARHGAP9

3.26e-0544944CID005311149
DrugFm 4-64

GPHN ACTBL2 ACTB ACTG1 TG

3.59e-0590945CID002733635
DrugAC1NRCMD

ACTL7B NOG ACTB ACTG1 ACTG2

3.59e-0590945CID005289074
DrugAC1L22RD

ACTL7B ACTBL2 ACTB ACTG1 ACTG2

3.79e-0591945CID000065183
DrugAC1L1IZ2

ACTL7B ACTBL2 ACTB ACTG1 ACTG2 MYO15A RYR2 ITPK1

3.79e-05304948CID000004795
Drugfasudil

ACTL7B ACTBL2 ACTB ACTG1 ACTG2 SMAD2

3.88e-05151946CID000003547
Drugcarbodiimide

ACTL7B ACTBL2 ACTB ACTG1 ACTG2 TG

3.88e-05151946CID000009864
DrugC18:1n-7

ACTL7B ACTBL2 ACTB ACTG1 ACTG2

3.99e-0592945CID000122325
Drugcnicin

ACTL7B PIK3CG ACTB ACTG1 ACTG2

3.99e-0592945CID000091176
Drugauxin

ACTL7B ACTBL2 EPC1 ACTB ACTG1 ACTG2 ANKRD12

4.02e-05224947CID000000801
DrugAC1L1GXW

ACTL7B ACTBL2 ACTB ACTG1 ACTG2

4.43e-0594945CID000003891
DrugZnBr2

SYNE1 ARHGAP9

5.05e-053942CID000024375
DrugNSC3096

ACTL7B ACTBL2 ACTB ACTG1 ACTG2

5.40e-0598945CID000002832
Drugtetramethylrhodamine

GPHN ACTBL2 ACTB ACTG1

5.43e-0550944CID000065219
DrugNSC106399

ACTL7B ACTB ACTG1 ACTG2

5.87e-0551944CID000002887
Drugsulphoxide

ACTL7B SYNE1 ACTB ACTG1 ACTG2

6.24e-05101945CID000008442
Drug5'IATR

ACTBL2 ACTB ACTG1

6.29e-0519943CID000074997
DrugNSC339663

ACTL7B SYNE1 ACTBL2 ACTB ACTG1 ACTG2 MYO15A

8.04e-05250947CID000003892
Drugmethyl vinyl ketone

PTCHD3 SYNE1 ARHGAP9

8.59e-0521943CID000006570
DrugMgamp-pnp

ACTBL2 ACTB ACTG1

8.59e-0521943CID005311323
DrugBADGE

ACTBL2 ACTB ACTG1 SMAD2

9.75e-0558944CID000002286
Drugmethyl propynoate

SYNE1 ARHGAP9

1.01e-044942CID000013536
DrugAC1L9STC

SYNE1 ARHGAP9

1.01e-044942CID000455431
Drugsulfinosine

SYNE1 ARHGAP9

1.01e-044942CID000130209
Drugtrichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A

TXNIP SLC2A6 RIPK4 TEX14 DENND3 AHNAK2

1.09e-041829467043_UP
DrugHU-211

ACTL7B ACTBL2 ACTB ACTG1 ACTG2

1.11e-04114945CID000107778
DrugAspidium

ACTL7B PRR12 ACTBL2 ACTB ACTG1 ACTG2

1.16e-04184946CID000000815
DrugK-Cl

ACTL7B CACNA1E CLN3 ACTBL2 ACTB ACTG1 ACTG2 UBXN1 MYO15A RYR2

1.17e-045679410CID000004873
DrugAC1NSKHI

ACTBL2 ACTB ACTG1 DGKI

1.19e-0461944CID005311358
Drugglycerophosphoinositol

ACTBL2 ACTB ACTG1 PPP1R1A

1.27e-0462944CID000167572
DrugNbd-Ph

ACTBL2 ACTB ACTG1

1.30e-0424943CID004682184
DrugPb m

ACTL7B ACTBL2 ACTB ACTG1 ACTG2

1.30e-04118945CID006327255
DrugTCNB

ACTL7B ACTB ACTG1 ACTG2 RYR2

1.36e-04119945CID000008330
DrugMAPS

ACTL7B ACTBL2 ACTB ACTG1 ACTG2 MSLN

1.42e-04191946CID000066161
DrugForskolin, from Coleus forskohlii; Down 200; 0.5uM; PC3; HT_HG-U133A

SETD1B MAST4 SYNE1 ASPSCR1 DENND3 DHX9

1.51e-041939467059_DN
DrugFluoxetine hydrochloride [59333-67-4]; Up 200; 11.6uM; PC3; HT_HG-U133A

CCDC87 ACTG2 POU2F2 E2F2 ITPK1 PPP1R1A

1.51e-041939466757_UP
DrugAC1OAGKW

ACTL7B PIK3CG ACTB ACTG1 ACTG2 DGKI

1.51e-04193946CID006857413
Drugnocodazole

ACTL7B GPHN ACTBL2 ACTB ACTG1 ACTG2 MSLN TG NIN

1.59e-04477949CID000004122
DrugNSC3260

ACTL7B DAB2IP ACTB ACTG1 ACTG2 RYR2

1.59e-04195946CID000220461
DrugRolipram [61413-54-5]; Up 200; 14.6uM; MCF7; HT_HG-U133A

ZKSCAN3 ACTG2 POU2F2 PARD3 ITPK1 AHNAK2

1.59e-041959465330_UP
DrugAzathymine, 6 [932-53-6]; Up 200; 31.4uM; MCF7; HT_HG-U133A

POU2F2 TEX14 UBXN1 AHNAK2 PHLPP2 TG

1.64e-041969464106_UP
DrugTorsemide [56211-40-6]; Up 200; 11.4uM; MCF7; HT_HG-U133A

AKAP6 IPO8 APBA2 POU2F2 BCL11A TEX14

1.64e-041969463517_UP
DrugTrimethoprim [738-70-5]; Down 200; 13.8uM; PC3; HT_HG-U133A

IPO8 LSG1 SYNE1 C1QTNF1 UBXN1 DENND3

1.64e-041969467377_DN
DrugYohimbinic acid monohydrate [27801-27-2]; Up 200; 11.2uM; MCF7; HT_HG-U133A

RPAP1 APBA2 DDX51 TEX14 PHLPP2 TG

1.68e-041979462803_UP
Drug0198306-0000 [212631-61-3]; Down 200; 10uM; PC3; HT_HG-U133A

SYNE1 CLN3 BCL11A DENND3 ARHGEF10L DHX9

1.68e-041979467069_DN
DrugCarbinoxamine maleate salt [3505-38-2]; Down 200; 9.8uM; PC3; HT_HG-U133A

FOXJ2 SLC4A7 SETD1B SLC2A6 TACC2 PHLPP2

1.68e-041979467138_DN
DrugZalcitabine [7481-89-2]; Down 200; 19uM; MCF7; HT_HG-U133A

SLC4A7 IPO8 RPAP1 ZKSCAN3 ZNF623 RYR2

1.68e-041979467352_DN
DrugProcaine hydrochloride [51-05-8]; Up 200; 14.6uM; HL60; HT_HG-U133A

RPAP1 PARD3 CEP164 ADGRL3 RYR2 ITPK1

1.73e-041989461838_UP
DrugSpectinomycin dihydrochloride [21736-83-4]; Down 200; 9.8uM; MCF7; HT_HG-U133A

GPHN TXNIP PHACTR4 ZKSCAN3 ACTB ANKRD12

1.73e-041989464773_DN
DrugAjmalicine hydrochloride [4373-34-6]; Up 200; 10.2uM; HL60; HG-U133A

AKAP6 PIK3CG ZKSCAN3 PARD3 ZNF623 ITPK1

1.73e-041989461748_UP
DrugPHA-00745360 [351320-33-7]; Up 200; 1uM; PC3; HT_HG-U133A

CLN3 APBA2 POU2F2 DDX51 ASPSCR1 PHLPP2

1.73e-041989464562_UP
DrugFlunarizine dihydrochloride [30484-77-6]; Down 200; 8.4uM; MCF7; HT_HG-U133A

TXNIP SLC4A7 SETD1B MTCL1 ARHGAP11A ARHGEF10L

1.73e-041989467013_DN
DrugReserpinic acid hydrochloride; Up 200; 9.2uM; PC3; HT_HG-U133A

MAST4 CCDC87 POU2F2 C1QTNF1 ITPK1 PPP1R1A

1.73e-041989466603_UP
DrugProparacaine hydrochloride [5875-06-9]; Up 200; 12uM; MCF7; HT_HG-U133A

SLC4A7 SETD1B C1QTNF1 ASPSCR1 AHNAK2 PHLPP2

1.78e-041999465433_UP
DrugHyoscyamine (L) [101-31-5]; Up 200; 13.8uM; HL60; HG-U133A

TXNIP APBA2 ANKRD12 MTCL1 PHLPP2 DHX9

1.78e-041999461424_UP
DrugAC1MNW2N

ACTL7B ACTB ACTG1 ACTG2

2.03e-0470944CID003359490
Diseaseautosomal dominant nonsyndromic deafness 20 (implicated_via_orthology)

ACTBL2 ACTB ACTG1 ACTG2 POTEKP

1.55e-118935DOID:0110550 (implicated_via_orthology)
DiseaseBaraitser-Winter syndrome 1 (implicated_via_orthology)

ACTBL2 ACTB ACTG1 ACTG2 POTEKP

1.55e-118935DOID:0081112 (implicated_via_orthology)
DiseaseMoyamoya disease (implicated_via_orthology)

ACTBL2 ACTB ACTG1 ACTG2 POTEKP

1.55e-118935DOID:13099 (implicated_via_orthology)
Diseasethoracic aortic aneurysm (implicated_via_orthology)

ACTBL2 ACTB ACTG1 ACTG2 POTEKP

1.55e-118935DOID:14004 (implicated_via_orthology)
Diseaseintestinal atresia (implicated_via_orthology)

ACTBL2 ACTB ACTG1 ACTG2 POTEKP

6.94e-1110935DOID:10486 (implicated_via_orthology)
Diseasepatent ductus arteriosus (implicated_via_orthology)

ACTBL2 ACTB ACTG1 ACTG2 POTEKP

6.94e-1110935DOID:13832 (implicated_via_orthology)
DiseaseIris Coloboma with Ptosis, Hypertelorism, and Mental Retardation

ACTB ACTG1

9.83e-062932C1855722
DiseaseBaraitser-Winter syndrome

ACTB ACTG1

9.83e-062932cv:C1853623
DiseaseFryns-Aftimos Syndrome

ACTB ACTG1

9.83e-062932C1853623
Diseasecortical thickness

AKAP6 MAST4 IGHA2 ASIC2 NBEAL1 FAM178B DOCK7 DGKI C1QTNF1 TACC2 MTCL1 PARD3 DENND3 TG

1.00e-0511139314EFO_0004840
DiseaseFEV/FEC ratio

AKAP6 PRR12 LLGL2 NOG RPAP1 EPC1 ASPSCR1 MTCL1 BCL11A MYO15A PARD3 DENND3 ITPK1 TG

2.99e-0512289314EFO_0004713
DiseaseUveoretinal Coloboma

ACTB ACTG1

2.04e-047932C4554007
DiseaseCongenital ocular coloboma (disorder)

ACTB ACTG1

3.49e-049932C0009363
Diseasefolic acid measurement

ASIC2 WNT9A MYO15A

4.17e-0446933EFO_0005111
DiseaseCongenital neurologic anomalies

ACTB ACTG1

4.35e-0410932C0497552
DiseaseCranioschisis

ACTB ACTG1

4.35e-0410932C0265541
Diseasevital capacity

CDK5RAP3 LLGL2 NOG IPO8 SYNE1 WNT9A ACTG1 ASPSCR1 MTCL1 PARD3 C8orf34 RYR2

5.04e-0412369312EFO_0004312
DiseaseDiffuse Large B-Cell Lymphoma

TXNIP KMT2D PIK3CG

7.06e-0455933C0079744
DiseaseNonsyndromic genetic hearing loss

OTOF ACTG1 MYO15A

1.80e-0376933cv:C5680182
Diseasealcohol consumption measurement

AKAP6 CACNA1E MAST4 CLN3 ACTG1 POU2F2 C1QTNF1 ASPSCR1 MYO15A PARD3 PHLPP2

1.82e-0312429311EFO_0007878
DiseaseDisease Exacerbation

TXNIP CLN3 E2F2 UBXN1

1.87e-03165934C0235874
DiseaseMalignant neoplasm of breast

AKAP6 KMT2D LLGL2 DSC3 OTOF SYNE1 TACC2 BCL11A ARHGAP11A TREML1

2.06e-0310749310C0006142
DiseaseICAM-1 measurement

FDX2 RAVER1

2.59e-0324932EFO_0004520
Diseasetemperament and character inventory

APBA2 TG

2.59e-0324932EFO_0004825

Protein segments in the cluster

PeptideGeneStartEntry
PLPVFRCEDLPDLHE

EPC1

16

Q9H2F5
APERDTDPPLIHLDS

ARHGEF10L

56

Q9HCE6
EPVDREPVVCHPDLE

ASPSCR1

316

Q9BZE9
LPEEHAVLVSDPPLS

ACTL7B

141

Q9Y614
EADTPLVLPHPELEV

CACNA1E

1001

Q15878
RVAPDEHPILLTEAP

ACTBL2

96

Q562R1
VAPEEHPILLTEAPL

POTEKP

96

Q9BYX7
VAPEEHPVLLTEAPL

ACTB

96

P60709
VAPEEHPVLLTEAPL

ACTG1

96

P63261
LELIHEESDAPLLPP

ADGRL3

1296

Q9HAR2
ESLPILHSPDEKIPD

C8orf34

426

Q49A92
RVAPEEHPTLLTEAP

ACTG2

96

P63267
PIPEDEPSVLEAHDQ

APBA2

166

Q99767
PALHERELDSLADLP

ANKRD12

1256

Q6UB98
SLEIQHPPPLLEDEE

CCDC87

631

Q9NVE4
LPEQAEDHVPPVLRL

CFAP73

21

A6NFT4
DPESPILDLDLHLPL

DENND3

181

A2RUS2
LQIPDPHLADPSVLE

ASIC2

121

Q16515
LLKEPHPPRLSAEEA

NBEAL1

2276

Q6ZS30
LPPLDPEEIRKRLEH

RAVER1

36

Q8IY67
RELPEPILPADLHEA

ARHGAP11B

126

Q3KRB8
ALSLDDEPEEPPAHR

MTCL1

1346

Q9Y4B5
VKEVHDELEDLPSPP

GPHN

176

Q9NQX3
PDPPHRDRLRSKDEL

DAB2IP

1021

Q5VWQ8
DDDDPEPLVAVPHRI

MAP4K3

301

Q8IVH8
PLRKETEPHHELPDS

MAP4K3

341

Q8IVH8
DAHPETIVLDPLPAI

ITPK1

86

Q13572
SVPLPEPLEVAHDLS

LLGL2

786

Q6P1M3
EDEDPHRPPTSEELL

LSG1

496

Q9H089
RAPLEHRESPREPED

MYO15A

901

Q9UKN7
PSELPQLLPDLESHV

JMJD7

136

P0C870
IPRHPDELELDVDDP

MAPK8IP2

616

Q13387
PLEAILTDDEPDHGP

BCL11A

21

Q9H165
LSTPLPEPHIDLELV

C9orf131

691

Q5VYM1
RELPPPEDDQLHSSA

EXD2

51

Q9NVH0
VSEDHLDLLPPPEER

FDX2

121

Q6P4F2
PLKEEEEAPLLPRTH

ISM2

56

Q6H9L7
EEAPLLPRTHLQAEP

ISM2

61

Q6H9L7
PHRPRLLDPDSVDDE

KCNIP2

66

Q9NS61
PSHPEEPSDLEELEQ

POU2F2

191

P09086
HRLSEPPEDLDALPL

MSLN

106

Q13421
PDISRKRRHPPDDDL

FOXJ2

146

Q9P0K8
PVIPALERSLDPDLH

SLC2A6

61

Q9UGQ3
EIEFPPSLDLHQEIP

PHACTR4

371

Q8IZ21
VAPEEHPILLTEAPL

POTEE

796

Q6S8J3
EELPSPPDHAERAEE

C1QTNF1

41

Q9BXJ1
VPLEATDSLLELPHP

E2F2

366

Q14209
FALHPSPDEEEPIER

DOCK7

236

Q96N67
EPIERLSVPDIPKEH

DOCK7

246

Q96N67
PLPLPIRVEDENDNH

DSC3

226

Q14574
LVPIEDIPDVHPDLQ

DDX51

196

Q8N8A6
NLHVERNPDLPPEEL

DGKI

501

O75912
EPSVVERPHLEELPE

CDK5RAP3

246

Q96JB5
EEQDEELDHILSPPP

MAST4

116

O15021
EEEREHDLPTHPRGP

FAM163A

46

Q96GL9
EVHLLPPPSEELALN

IGHA2

216

P01877
PPSDAADEEHRPLLL

SLC45A1

766

Q9Y2W3
PPEEDEGTKRVDPLH

RYR2

3651

Q92736
RHDAELRVPSPTEEP

MFSD5

431

Q6N075
FDLELVDPDTPLPHV

CYP8B1

461

Q9UNU6
IEPPPLDAVIEAEHT

DHX9

821

Q08211
LPEEETPEPTAICRH

PTCHD3

96

Q3KNS1
LVPEHVETRPLLNPD

OTOF

1681

Q9HC10
IEDDRLPVLPPHLSD

PARD3

761

Q8TEW0
APSDNLPLVDLIEHP

NOG

36

Q13253
LPLVDLIEHPDPIFD

NOG

41

Q13253
VPPETLHIDEDDRPE

IPO8

241

O15397
RELPEPILPADLHEA

ARHGAP11A

126

Q6P4F7
DDIPTVVIHPPEEDL

SLC4A7

341

Q9Y6M7
HIDELPPPSQELLDD

TEX14

1326

Q8IWB6
IRLPLPDDEHDLSDR

SYNE1

8211

Q8NF91
IEPLDEEARPSHIPA

NIN

126

Q8N4C6
LDLDEEEVPLTPEHR

FAM178B

231

Q8IXR5
ESPRSPEEEEPHLLS

CCT8L1P

21

A6NM43
ESPRSPEEEEPHLLS

CCT8L2

21

Q96SF2
PLSPERAPEHDLEVE

SETD1B

1296

Q9UPS6
VAPEEHPILLTEAPL

POTEI

796

P0CG38
EDPELPDTRPLHLAK

PRR12

1536

Q9ULL5
AHDLDVKSPPEPRSE

RIPK4

346

P57078
TELQPDVPPHERILA

AKAP6

1516

Q13023
PEADLPLPKHDLSTE

AHNAK2

5116

Q8IVF2
GLEERLSPPLPHEER

CEP164

466

Q9UPV0
GEETVPEPRLPLLDH

CLN3

16

Q13286
EEIHVVLDTPPDPAL

PIK3CG

301

P48736
EDALLLPDLSLHVPP

ZNF513

266

Q8N8E2
PRTEPCLSPEDEEHV

ZFP41

46

Q8N8Y5
SRLEPEPHEEDRTEP

PHLPP2

1301

Q6ZVD8
PRHTEILTELPPLDD

SMAD2

181

Q15796
RPLPQLLDDPHEVEK

ARHGAP9

311

Q9BRR9
LAPEELHTDRESPRP

TACC2

1811

O95359
PGHCLPEDEDPEERL

RPAP1

81

Q9BWH6
EEESRPPPDLARHDV

RPAP1

521

Q9BWH6
PDVDEPLETPLGHIL

UBXN1

46

Q04323
DPLPRTPELVHLDDS

WNT9A

281

O14904
RDLPPAEELPEKEHG

ZKSCAN3

261

Q9BRR0
PEAPREVLLHPLVAE

VSIG10L

576

Q86VR7
PESEEVHEPRLGELL

ZNF623

46

O75123
PAAELPLDVPHIRLD

TREML1

221

Q86YW5
DVIPEDHRLESPTTP

TXNIP

336

Q9H3M7
RLEDIPVASLPDLHD

TG

1371

P01266
SSPEIDEDRIPNPHL

PPP1R1A

46

Q13522
PEELHLSPQTEEPHL

KMT2D

801

O14686