Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionH3K27me3 modified histone binding

TAF1 TAF1L

2.03e-055292GO:0061628
GeneOntologyMolecularFunctionRNA polymerase I general transcription initiation factor activity

TAF1 TAF1L

7.29e-059292GO:0001181
GeneOntologyMolecularFunctionRNA polymerase II core promoter sequence-specific DNA binding

TAF1 TAF1L

5.98e-0425292GO:0000979
GeneOntologyMolecularFunctionRNA polymerase II general transcription initiation factor binding

TAF1 TAF1L

6.99e-0427292GO:0001091
GeneOntologyMolecularFunctionlysine-acetylated histone binding

TAF1 TAF1L

8.64e-0430292GO:0070577
GeneOntologyMolecularFunctionacetylation-dependent protein binding

TAF1 TAF1L

9.23e-0431292GO:0140033
GeneOntologyMolecularFunctionTBP-class protein binding

TAF1 TAF1L

1.05e-0333292GO:0017025
GeneOntologyMolecularFunctiontranscription regulator inhibitor activity

TAF1 TAF1L

1.24e-0336292GO:0140416
GeneOntologyMolecularFunctionubiquitin conjugating enzyme activity

TAF1 TAF1L

1.31e-0337292GO:0061631
GeneOntologyMolecularFunctionprotein kinase activity

TAF1 HK1 PEAK1 TAF1L LRRK2

1.57e-03600295GO:0004672
GeneOntologyMolecularFunctionubiquitin-like protein conjugating enzyme activity

TAF1 TAF1L

1.77e-0343292GO:0061650
GeneOntologyMolecularFunctionhistone acetyltransferase activity

TAF1 TAF1L

2.48e-0351292GO:0004402
GeneOntologyMolecularFunctionRNA polymerase II general transcription initiation factor activity

TAF1 TAF1L

2.58e-0352292GO:0016251
GeneOntologyMolecularFunctioncore promoter sequence-specific DNA binding

TAF1 TAF1L

2.88e-0355292GO:0001046
GeneOntologyMolecularFunctionpeptide-lysine-N-acetyltransferase activity

TAF1 TAF1L

2.88e-0355292GO:0061733
GeneOntologyMolecularFunctionphosphotransferase activity, alcohol group as acceptor

TAF1 HK1 PEAK1 TAF1L LRRK2

3.25e-03709295GO:0016773
GeneOntologyMolecularFunctionpeptide N-acetyltransferase activity

TAF1 TAF1L

3.42e-0360292GO:0034212
GeneOntologyMolecularFunctiongeneral transcription initiation factor binding

TAF1 TAF1L

3.88e-0364292GO:0140296
GeneOntologyMolecularFunctionbasal RNA polymerase II transcription machinery binding

TAF1 TAF1L

4.12e-0366292GO:0001099
GeneOntologyMolecularFunctionbasal transcription machinery binding

TAF1 TAF1L

4.12e-0366292GO:0001098
GeneOntologyMolecularFunctiongeneral transcription initiation factor activity

TAF1 TAF1L

4.37e-0368292GO:0140223
GeneOntologyMolecularFunctionkinase activity

TAF1 HK1 PEAK1 TAF1L LRRK2

4.48e-03764295GO:0016301
GeneOntologyMolecularFunctionp53 binding

TAF1 TAF1L

5.57e-0377292GO:0002039
GeneOntologyMolecularFunctionN-acetyltransferase activity

TAF1 TAF1L

5.71e-0378292GO:0008080
GeneOntologyMolecularFunctionpromoter-specific chromatin binding

TAF1 TAF1L

6.44e-0383292GO:1990841
GeneOntologyMolecularFunctionmethylated histone binding

TAF1 TAF1L

6.90e-0386292GO:0035064
GeneOntologyMolecularFunctionmethylation-dependent protein binding

TAF1 TAF1L

7.22e-0388292GO:0140034
GeneOntologyMolecularFunctionN-acyltransferase activity

TAF1 TAF1L

9.59e-03102292GO:0016410
GeneOntologyMolecularFunctionacetyltransferase activity

TAF1 TAF1L

9.95e-03104292GO:0016407
GeneOntologyMolecularFunctionmolecular function inhibitor activity

SPINT4 TAF1 TAF1L LRRK2

1.03e-02596294GO:0140678
GeneOntologyMolecularFunctiontransferase activity, transferring phosphorus-containing groups

TAF1 HK1 PEAK1 TAF1L LRRK2

1.05e-02938295GO:0016772
GeneOntologyMolecularFunctionsmall GTPase binding

BICDL2 ARHGAP44 LRRK2

1.10e-02321293GO:0031267
GeneOntologyBiologicalProcessregulation of protein autoubiquitination

TAF1 LRRK2

2.85e-056292GO:1902498
MousePhenodetached tectorial membrane

OTOA MYO6

3.28e-057182MP:0003150
DomainTAF_II_230-bd

TAF1 TAF1L

2.01e-062272IPR009067
DomainDUF3591

TAF1 TAF1L

2.01e-062272PF12157
DomainTFIID_sub1_DUF3591

TAF1 TAF1L

2.01e-062272IPR022591
Domain-

TAF1 TAF1L

2.01e-0622721.10.1100.10
DomainTBP-binding

TAF1 TAF1L

2.01e-062272PF09247
DomainTAF1_animal

TAF1 TAF1L

2.01e-062272IPR011177
DomainBromodomain_CS

TAF1 TAF1L BAZ2B

6.85e-0626273IPR018359
DomainBROMODOMAIN_1

TAF1 TAF1L BAZ2B

2.03e-0537273PS00633
DomainBromodomain

TAF1 TAF1L BAZ2B

2.20e-0538273PF00439
DomainBROMODOMAIN_2

TAF1 TAF1L BAZ2B

2.77e-0541273PS50014
DomainBROMO

TAF1 TAF1L BAZ2B

2.98e-0542273SM00297
DomainBromodomain

TAF1 TAF1L BAZ2B

2.98e-0542273IPR001487
Domain-

TAF1 TAF1L BAZ2B

2.98e-05422731.20.920.10
Domain-

ICA1 ARHGAP44

8.54e-04302721.20.1270.60
DomainAH/BAR-dom

ICA1 ARHGAP44

8.54e-0430272IPR027267
DomainPHD

BAZ2B PHF3

5.23e-0375272PF00628
DomainZnf_PHD-finger

BAZ2B PHF3

5.79e-0379272IPR019787
DomainPHD

BAZ2B PHF3

7.29e-0389272SM00249
DomainZnf_PHD

BAZ2B PHF3

7.61e-0391272IPR001965
DomainZF_PHD_2

BAZ2B PHF3

8.27e-0395272PS50016
DomainZF_PHD_1

BAZ2B PHF3

8.44e-0396272PS01359
Pubmed

Taf1 knockout is lethal in embryonic male mice and heterozygous females show weight and movement disorders.

TAF1 TAF1L

6.71e-07229238804708
Pubmed

TAFII250, Egr-1, and D-type cyclin expression in mice and neonatal rat cardiomyocytes treated with doxorubicin.

TAF1 TAF1L

6.71e-07229210070062
Pubmed

Sustained expression of a neuron-specific isoform of the Taf1 gene in development stages and aging in mice.

TAF1 TAF1L

6.71e-07229222842574
Pubmed

Overexpression of Protein Phosphatase 2 Regulatory Subunit B"Alpha Promotes Glycolysis by Regulating Hexokinase 1 in Hepatocellular Carcinoma.

PPP2R3A HK1

6.71e-07229235945177
Pubmed

Frameshift Mutations in the Mononucleotide Repeats of TAF1 and TAF1L Genes in Gastric and Colorectal Cancers with Regional Heterogeneity.

TAF1 TAF1L

6.71e-07229227571988
Pubmed

Striatal Cholinergic Dysregulation after Neonatal Decrease in X-Linked Dystonia Parkinsonism-Related TAF1 Isoforms.

TAF1 TAF1L

6.71e-07229234403156
Pubmed

TAFII55 binding to TAFII250 inhibits its acetyltransferase activity.

TAF1 TAF1L

2.01e-06329211592977
Pubmed

Regulated expression of TAF1 in 1-cell mouse embryos.

TAF1 TAF1L

2.01e-06329216822332
Pubmed

Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis.

TAF1 TAF1L

2.01e-06329212217962
Pubmed

TAF7: a possible transcription initiation check-point regulator.

TAF1 TAF1L

2.01e-06329216407123
Pubmed

Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells.

TAF1 TAF1L

1.00e-05629219959467
Pubmed

Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome.

TAF1 TAF1L

1.87e-0582922034279
Pubmed

Genetic mapping in the region of the mouse X-inactivation center.

TAF1 TAF1L

1.87e-0582921974879
Pubmed

Deletion of Prl7d1 causes placental defects at mid-pregnancy in mice.

TAF1 TAF1L

1.87e-05829231012985
Pubmed

Physical mapping of 2000 kb of the mouse X chromosome in the vicinity of the Xist locus.

TAF1 TAF1L

1.87e-0582928468051
Pubmed

High-density molecular map of the central span of the mouse X chromosome.

TAF1 TAF1L

1.87e-0582921675191
Pubmed

Cloning and characterization of a new human Xq13 gene, encoding a putative helicase.

TAF1 TAF1L

2.41e-0592927874112
Pubmed

The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation.

TAF1 TAF1L

2.41e-05929212665565
Pubmed

HIV-1 tat binds TAFII250 and represses TAFII250-dependent transcription of major histocompatibility class I genes.

TAF1 TAF1L

2.41e-0592929751712
Pubmed

Genetic and molecular evidence of an X-chromosome deletion spanning the tabby (Ta) and testicular feminization (Tfm) loci in the mouse.

TAF1 TAF1L

3.01e-05102922055107
Pubmed

Characterization of a murine gene expressed from the inactive X chromosome.

TAF1 TAF1L

3.68e-05112922034278
Pubmed

The murine interleukin-2 receptor gamma chain gene: organization, chromosomal localization and expression in the adult thymus.

TAF1 TAF1L

5.21e-05132927805729
Pubmed

Mapping of loci and translocation breakpoints in Xq13: isolation of a conserved locus that maps close to CCG1 in human and mouse.

TAF1 TAF1L

5.21e-05132928012115
Pubmed

Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development.

TAF1 TAF1L

5.21e-051329211557891
Pubmed

Rps4 maps near the inactivation center on the mouse X chromosome.

TAF1 TAF1L

5.21e-05132921740345
Pubmed

XIST and the mapping of the X chromosome inactivation centre.

TAF1 TAF1L

5.21e-05132921772416
Pubmed

The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis.

TAF1 TAF1L

7.00e-051529214580349
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

SSB TAF1 TAF1L PHF3

8.68e-0528329430585729
Pubmed

Parkinson Disease Overview

TAF1 LRRK2

2.33e-042729220301402
Pubmed

Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.

TAF1 TAF1L

3.08e-043129225838543
Pubmed

HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences.

PPP2R3A TAF1

3.28e-043229211748221
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

PPP2R3A HK1 PEAK1 MYO6 LRRK2

4.18e-0477729535844135
Pubmed

Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).

ANKRD31 CCSER1

4.63e-043829222952603
Pubmed

Dominant and redundant functions of TFIID involved in the regulation of hepatic genes.

TAF1 TAF1L

5.93e-044329218722179
Pubmed

Oct4 links multiple epigenetic pathways to the pluripotency network.

TAF1 TAF1L PHF3

6.40e-0420329322083510
Pubmed

TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation.

TAF1 TAF1L

6.79e-044629225209997
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PEAK1 MYO6 BAZ2B CCSER1

7.15e-0449329415368895
Pubmed

Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation.

TAF1 TAF1L

8.02e-045029227026076
GeneFamilyPHD finger proteins

BAZ2B PHF3

2.47e-039015288
GeneFamilyActins|Deafness associated genes

OTOA MYO6

3.85e-031131521152
GeneFamilyRNA binding motif containing

NCBP2L SSB

1.31e-02213152725
ToppCellCOVID-19-Epithelial_cells-AT2|COVID-19 / group, cell type (main and fine annotations)

SDR16C5 MYO6 ARHGAP44 LRRK2 CCSER1

1.19e-07184295369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

EVC PPP2R3A MYO6 LRRK2 CCSER1

1.63e-071962956ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

BICDL2 MYO6 ARHGAP44 CCSER1

6.06e-06185294cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MYO6 ARHGAP44 LRRK2 CCSER1

6.20e-06186294acfa68a2afb7d2b51c9b469a1965fe5cc5d5e64e
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

EVC RIPOR3 PPP2R3A LRRK2

6.20e-06186294f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

EVC RIPOR3 PPP2R3A LRRK2

6.33e-06187294c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

BICDL2 SDR16C5 MYO6 LRRK2

6.33e-061872945df9e1f5ca32217af255e76e6fb5afa346337811
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

EVC RIPOR3 PPP2R3A LRRK2

6.46e-06188294af740fa78542438fdff627ea1f74f4eee43316be
ToppCellPCW_13-14-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ICA1 ARHGAP44 LRRK2 CCSER1

6.46e-061882940d86044bc340e3efb90d0022dd299873639d831c
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D175|Adult / Lineage, Cell type, age group and donor

SDR16C5 ARHGAP44 LRRK2 CCSER1

6.46e-06188294ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCellCOVID-19-lung-AT2|lung / Disease (COVID-19 only), tissue and cell type

SDR16C5 ARHGAP44 LRRK2 CCSER1

6.88e-06191294276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MYO6 ARHGAP44 LRRK2 CCSER1

7.02e-06192294fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

BICDL2 MYO6 ARHGAP44 LRRK2

7.02e-0619229429f49f00770c991b5f27e4cb701dd2d2d6cb7178
ToppCellFetal_29-31_weeks-Epithelial|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MYO6 ICA1 ARHGAP44 LRRK2

7.17e-06193294a0ca3231992f14abcf1a6129573bace320e89d2a
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BICDL2 MYO6 ARHGAP44 CCSER1

7.32e-061942944579b4a44f7c731553a284843c296866027d7c0e
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

BICDL2 MYO6 ARHGAP44 CCSER1

7.47e-061952943d6d3de8ada6dce3dc789c15b50cc066e7100496
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PPP2R3A MYO6 LRRK2 CCSER1

7.77e-061972947e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_alveolar-Dividing_AT2|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

ANKRD31 SDR16C5 ARHGAP44 CCSER1

8.25e-06200294befc25cbcbac2c02e5fd33d6e78e59979050090c
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

EVC PPP2R3A LRRK2

9.73e-05138293a88c3ae56b0af60f6e87cabade4f21e2bbb336f2
ToppCell5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-Myeloid-cDC1|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

BICDL2 LRRK2 CCSER1

1.25e-041502933dc23a37dbeb7f9df93683702a7838f7cc3ec9cc
ToppCell390C-Epithelial_cells-Epithelial-A_(AT2)|390C / Donor, Lineage, Cell class and subclass (all cells)

SDR16C5 MYO6 LRRK2

1.51e-04160293731def6d82814ebac1a400bc7aea5f6da43ec960
ToppCell390C-Epithelial_cells-Epithelial-A_(AT2)-|390C / Donor, Lineage, Cell class and subclass (all cells)

SDR16C5 MYO6 LRRK2

1.51e-04160293cf27b4ac4d0caa6f9b068dc8ea93472470a01a4d
ToppCell367C-Epithelial_cells-Epithelial-A_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

EVC SDR16C5 LRRK2

1.62e-04164293b0ed8cb6000ce8bf94444307e4b7b3574fa3fab2
ToppCell368C-Epithelial_cells-Epithelial-A_(AT2)-|368C / Donor, Lineage, Cell class and subclass (all cells)

BICDL2 SDR16C5 LRRK2

1.62e-0416429385f53d184fa70e3eb1af655807f32b17ddbfb304
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EVC PPP2R3A LRRK2

1.62e-041642931cb5fbd7050650047ad6f2ca792118e98d58d22b
ToppCell343B-Epithelial_cells-Epithelial-A_(AT2)-|343B / Donor, Lineage, Cell class and subclass (all cells)

SDR16C5 MYO6 LRRK2

1.62e-04164293beaa13a75c3bb72446c85084d75e9fe3f15fd3d4
ToppCell367C-Epithelial_cells-Epithelial-A_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

EVC SDR16C5 LRRK2

1.62e-041642933aea6207a011ad55a1aeb2ed9fb54d31b23694b5
ToppCell368C-Epithelial_cells-Epithelial-A_(AT2)|368C / Donor, Lineage, Cell class and subclass (all cells)

BICDL2 SDR16C5 LRRK2

1.62e-04164293144ba070a1ede71684224cc6d4ead3b7e6a7b4c6
ToppCell343B-Epithelial_cells-Epithelial-A_(AT2)|343B / Donor, Lineage, Cell class and subclass (all cells)

SDR16C5 MYO6 LRRK2

1.62e-04164293d005cfd821b87548b075120bffe65a0be9860463
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EVC RIPOR3 LRRK2

1.80e-041702935d5f208682be21ed58320f5fc083a7898f8712da
ToppCellBac-SEP-Myeloid-cDC1|Bac-SEP / Disease, Lineage and Cell Type

EVC CFI CCSER1

1.90e-04173293f88269327441858ddb8c49b9dd619b76fd53b1da
ToppCellURO-Myeloid-cDC1|URO / Disease, Lineage and Cell Type

BICDL2 CFI CCSER1

1.90e-0417329357f4e9f39ef6e02dca76f3dd0b39a0871917ed5a
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CCDC68 SDR16C5 LRRK2

2.00e-0417629340993c41c1017b53039a337174fc56632b278609
ToppCellLPS-IL1RA+antiTNF|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BAZ2B PHF3 LRRK2

2.03e-04177293b7fee75de7e96924af488a5baa2334711889ae7c
ToppCell390C-Epithelial_cells-Epithelial-B_(AT2)|390C / Donor, Lineage, Cell class and subclass (all cells)

SDR16C5 ARHGAP44 LRRK2

2.10e-04179293466da2bc3bfc534ffe111c8c28ece7a3cfa08051
ToppCell390C-Epithelial_cells-Epithelial-B_(AT2)-|390C / Donor, Lineage, Cell class and subclass (all cells)

SDR16C5 ARHGAP44 LRRK2

2.10e-04179293f4bdebb77d39e63160fbf3a85a340ce4d52b7cfd
ToppCellCOVID-19-Epithelial_cells-AT1|COVID-19 / group, cell type (main and fine annotations)

MYO6 ARHGAP44 CCSER1

2.10e-04179293a0b33bd69ffdfd5d38d80207fb40058a490aa19e
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EVC RIPOR3 LRRK2

2.17e-041812939d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCellControl-Epithelial_cells-Airway_club|Control / group, cell type (main and fine annotations)

MYO6 LRRK2 CCSER1

2.17e-04181293c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EVC RIPOR3 LRRK2

2.20e-04182293eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCellCOPD-Epithelial-ATII|World / Disease state, Lineage and Cell class

SDR16C5 MYO6 LRRK2

2.24e-041832938e9aab4eeec2e282c2cab9bfca6dbf40d660c7b9
ToppCell3'_v3-GI_small-bowel-Myeloid_Dendritic-DC1|GI_small-bowel / Manually curated celltypes from each tissue

CFI LRRK2 CCSER1

2.27e-041842938e393eea7240584a3cef718bee094e2705ec1891
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)-Goblet_(bronchial)_L.0.4.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BICDL2 ICA1 CCSER1

2.27e-0418429301c19a830348ab0b9c02c1546a439de70ee10f97
ToppCellAT2_cells-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

CFI SDR16C5 LRRK2

2.31e-041852933b3268e3f99121124e33086cac88479808d31630
ToppCell10x5'v1-week_17-19-Hematopoietic-erythroid-mid_erythroid|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

CCDC68 RIPOR3 UROS

2.31e-04185293e9059cefcdf0972ec90793b1dd34c3292b17a061
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.4.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFI SDR16C5 LRRK2

2.31e-041852937460387f48f33674330bd53b759681b264228f5a
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

BICDL2 ARHGAP44 LRRK2

2.35e-041862932ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCellPCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

ICA1 ARHGAP44 CCSER1

2.35e-04186293bb0bfe9a015151be08a6ffc5d82896d0556d76de
ToppCellCOPD-Epithelial-ATII|Epithelial / Disease state, Lineage and Cell class

RIPOR3 SDR16C5 LRRK2

2.38e-04187293030af361f8bdcd0aff4ec1922702833325cf74d8
ToppCellwk_08-11-Hematologic-Meg-ery-Cycling_definitive_erythroblast|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

RIPOR3 HK1 UROS

2.38e-04187293c0965293f08d3e49000871777a5b26d81a4af203
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EVC RIPOR3 LRRK2

2.38e-04187293c41a2c81dd2ceef303f39f699032aa7d6ea67cf0
ToppCellPCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

ICA1 ARHGAP44 CCSER1

2.38e-04187293db2974e2e87ac9f1c2407a371d5ed89af09fc9b7
ToppCellCOVID-19-kidney-Mito-rich_Distal|kidney / Disease (COVID-19 only), tissue and cell type

PPP2R3A LRRK2 CCSER1

2.38e-041872932ce8038d9d1302e850c1bb536e755598f77ba4b9
ToppCellControl-Epithelial_cells|Control / group, cell type (main and fine annotations)

MYO6 ARHGAP44 LRRK2

2.42e-04188293707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCellCOVID-19-Epithelial_cells|COVID-19 / group, cell type (main and fine annotations)

MYO6 ARHGAP44 CCSER1

2.42e-04188293c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EVC RIPOR3 LRRK2

2.50e-041902931cf023e3c6924d6a06f353d4b62444b6f2fee8a7
ToppCellBL-critical-LOC-Epithelial-Secretory|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CCDC68 CFI SDR16C5

2.50e-04190293f2abe4bc28e934287e2dcd7b9399d5af78c5c8cf
ToppCellCOVID-19-lung-AT2|COVID-19 / Disease (COVID-19 only), tissue and cell type

SDR16C5 ARHGAP44 LRRK2

2.50e-0419029327a1a86620fe9b5ee930d388b32352206485e6d0
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BICDL2 ICA1 CCSER1

2.50e-041902933c337374d89e69cc0a78e65a4a7e21db7b050fcd
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EVC LRRK2 CCSER1

2.50e-041902933fc9e18c7441c0ae8cda65753cc42d0520f4e116
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

BICDL2 ICA1 CCSER1

2.50e-0419029323f2ac4da431211084bb6ab0494c2e0b69547cb6
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EVC RIPOR3 LRRK2

2.50e-0419029359bbbd2c8d4b7ce46c54ca8022b1557e7e5eee2a
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MYO6 ARHGAP44 LRRK2

2.54e-04191293ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ARHGAP44 LRRK2 CCSER1

2.54e-0419129334cc997e4e5c727495f321e6807a84aa124da486
ToppCellEpithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|World / Lineage, Cell type, age group and donor

MYO6 ARHGAP44 LRRK2

2.54e-04191293d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

EVC PPP2R3A LRRK2

2.54e-04191293d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCell367C-Epithelial_cells|367C / Donor, Lineage, Cell class and subclass (all cells)

BICDL2 SDR16C5 LRRK2

2.54e-04191293d31975fc33779b0b3ff1a50d7c64fec8d08be4d4
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

SDR16C5 ARHGAP44 LRRK2

2.58e-04192293cc9911e182a289779a2612bc213daae5607689e7
ToppCellfacs-Trachea-nan-18m-Epithelial-keratinocyte|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC68 BICDL2 SDR16C5

2.58e-041922934530b3028928d089b3a71eb19a4df237f58a50ae
ToppCellAdult-Epithelial|Adult / Lineage, Cell type, age group and donor

MYO6 ARHGAP44 LRRK2

2.58e-04192293efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCellEpithelial|World / Lineage, Cell type, age group and donor

MYO6 ARHGAP44 LRRK2

2.58e-04192293499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCellfacs-Trachea-nan-18m-Epithelial-new-cluster|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCDC68 BICDL2 SDR16C5

2.58e-04192293e4fb3f18da7dc6a835023db69a8d99737c39ef86
ToppCell10x3'2.3-week_12-13-Hematopoietic-erythroid|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

RIPOR3 HK1 UROS

2.58e-041922936ace9a34ed264583042156ed61c2cb3504a331d2
ToppCellVE-mDC1|VE / Condition, Cell_class and T cell subcluster

CFI LRRK2 CCSER1

2.62e-0419329312b2708db9db8b88365b8ebeb4908f28c50081bb
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PPP2R3A MYO6 CCSER1

2.62e-041932933866667dd221612589ae50f5c52f73a183a49ce6
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SDR16C5 MYO6 LRRK2

2.62e-04193293fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCellVE-mDC1-|VE / Condition, Cell_class and T cell subcluster

CFI LRRK2 CCSER1

2.62e-041932935df6033bc0e4f96a20d526486a8e89c990e21831
ToppCellwk_08-11-Hematologic-Meg-ery-Definitive_erythroblast|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

RIPOR3 SDE2 PCNT

2.62e-04193293be75abfdf5301cf33df8ee9ed92504d44fdf19a6
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

SDR16C5 MYO6 LRRK2

2.62e-04193293f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCell10x3'2.3-week_12-13-Hematopoietic-erythroid-mid_erythroid|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

CCDC68 RIPOR3 UROS

2.62e-041932931e19f80c52833fb21a8d597a3ba2c4ff464c4559
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PPP2R3A MYO6 CCSER1

2.62e-0419329382e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

EVC LRRK2 CCSER1

2.66e-04194293e577d9e88390b36b5a09b97fe1026089892275a3
ToppCellnucseq-Epithelial-Epithelial_Alveolar|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MYO6 ARHGAP44 LRRK2

2.66e-0419429353f3e49e91b1096f3226010e2de767efb490dfe4
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

EVC PPP2R3A CCSER1

2.66e-0419429393c68c31e39fa44c1d05d7d4997f4f086da4e738
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PPP2R3A MYO6 CCSER1

2.66e-041942935eaaa81f4b2535f983c424aaef00077089526a5c
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PPP2R3A MYO6 CCSER1

2.70e-041952936477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCellNS-critical-LOC-Epithelial-Secretory|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

BICDL2 CFI SDR16C5

2.70e-04195293b0d782eeee30c797b4da9b3be29b864983fd9e71
ToppCell10x3'2.3-week_14-16-Hematopoietic-erythroid-mid_erythroid|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

RIPOR3 HK1 UROS

2.70e-041952934759018a7c016cb2e3df5696f1e5f912c7c9ee17
ToppCellnucseq-Epithelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

MYO6 ARHGAP44 LRRK2

2.70e-041952939406866f99555198a9be311fbd65751b70f35446
ToppCellPCW_10-12-Epithelial-Epithelial_proliferating|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

CFI ICA1 CCSER1

2.70e-04195293ce1ba5911e8a6ddb07434acc37147c38e94245ff
ToppCellnormal_Lung-Epithelial_cells|normal_Lung / Location, Cell class and cell subclass

BICDL2 SDR16C5 LRRK2

2.70e-041952937c90d887afde5c4d63352b5171be9987e2dfca58
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ICA1 ARHGAP44 CCSER1

2.74e-04196293676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PPP2R3A MYO6 CCSER1

2.74e-04196293c7136b1c83bcf907eec3b02b151fa061298b6672
ToppCell10x3'2.3-week_17-19-Hematopoietic-erythroid-mid_erythroid|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

RIPOR3 HK1 UROS

2.74e-0419629351c48944149a89b98011a50fe81ca6664d5f0d44
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EVC PPP2R3A CCSER1

2.74e-04196293eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell10x3'2.3-week_17-19-Hematopoietic|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

RIPOR3 HK1 UROS

2.74e-041962932aeb792e7685e33e3543a6974be790980a41ed8c
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CFI SDR16C5 LRRK2

2.74e-0419629365e161fd672e37a5d10f28011bb422c4d7042d6a
ToppCell356C-Epithelial_cells-Epithelial-B_(AT2)-|356C / Donor, Lineage, Cell class and subclass (all cells)

SDR16C5 MYO6 LRRK2

2.78e-0419729306ed8f293d4ee89f14dc2f43d6cae93bbc02508a
ToppCell10x3'2.3-week_17-19-Hematopoietic-erythroid|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

RIPOR3 HK1 UROS

2.78e-04197293b71da7f2fd8d526fb6e5d57e60fc08acdd8dbefb
ToppCellASK452-Epithelial-Transformed_epithelium|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

CFI MYO6 LRRK2

2.78e-04197293b22a79a5922c865a360e2afc5506a08a512fa76a
DrugMfpa

TAF1 TAF1L

4.37e-063282CID003035615
Diseasetheophylline measurement

LRRK2 CCSER1

3.89e-0510282EFO_0021180
DiseaseNonsyndromic Hearing Loss and Deafness, Autosomal Recessive

OTOA MYO6

1.08e-0351282cv:CN043650
DiseaseMetastatic melanoma

TAF1 PEAK1

1.21e-0354282C0278883
DiseaseNonsyndromic genetic hearing loss

OTOA MYO6

2.37e-0376282cv:C5680182
DiseaseDisproportionate short stature

EVC PCNT

2.43e-0377282C0878659
Diseaseotosclerosis

PEAK1 CCSER1

2.69e-0381282EFO_0004213
DiseaseNonsyndromic Deafness

OTOA MYO6

2.69e-0381282C3711374
Diseaseage-related hearing impairment

CCDC68 PRR14L MYO6

3.51e-03324283EFO_0005782

Protein segments in the cluster

PeptideGeneStartEntry
ALIEMKKDGNKKDCE

CFI

431

P05156
AKELKKPNEDMCLAD

BAZ2B

1056

Q9UIF8
ECSMLKLQLKEKDEL

CCSER1

676

Q9C0I3
CSLDLLMKKIKGKDL

CCDC68

86

Q9H2F9
GKKFLDCPDELMEKS

SDR16C5

131

Q8N3Y7
MKVLLLKDAKEDDCG

UROS

1

P10746
ALDEAKDLCMKRLLE

ANKRD31

591

Q8N7Z5
AMKCLLEDKKDGLDL

OTOA

121

Q7RTW8
AEMKSLEEKIGCLLK

SSB

221

P05455
MSKDLKILCKDPALE

NCBP2L

1

A6PVI3
DALKKLAVKCEDLFM

PEAK1

1296

Q9H792
LLDDLMKKAEEGDLL

LRRK2

1826

Q5S007
AECLGDFMEKRKIKD

HK1

131

P19367
MCLDILLKCSEDLKK

PPP2R3A

231

Q06190
LDLKEQLEKMKGDLE

PCNT

1656

O95613
QKEKDLLLAAELGKM

BICDL2

56

A1A5D9
DCEGSALLKKALDAM

MCF2

651

P10911
ECELECLLKKMEIKG

CEP57L1

361

Q8IYX8
KMCLLDLLPKKKSDD

EVC

241

P57679
LELLGLEKLKCELMA

SDE2

396

Q6IQ49
LEKLKCELMALGLKC

SDE2

401

Q6IQ49
TDLKNLCKPKDGEML

PRR14L

1256

Q5THK1
DKLKMDVCQKVDLLG

ICA1

206

Q05084
SMLDLCDEKLKEKED

TAF1L

1491

Q8IZX4
QSMLDLCDEKLKEKE

TAF1

1471

P21675
LGKMLKLCGETEDKL

ARHGAP44

91

Q17R89
KGRLAFEKMDKLCSE

RIPOR3

916

Q96MK2
EKICGDLKDPCKLDM

SPINT4

31

Q6UDR6
LEMKDEDGLDSKHKC

PHF3

226

Q92576
CTAMKKIGLDDEEKL

MYO6

321

Q9UM54