Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionphosphatidic acid binding

RAPGEF6 RAPGEF2

2.34e-0424192GO:0070300
MousePhenoabnormal cell adhesion

RAPGEF6 DLC1 RAPGEF2

2.45e-0569123MP:0003566
DomainRasGEFN

RAPGEF6 RAPGEF2

1.47e-0420172SM00229
DomainRasGEF_N

RAPGEF6 RAPGEF2

1.62e-0421172PF00618
DomainRas-like_Gua-exchang_fac_N

RAPGEF6 RAPGEF2

1.78e-0422172IPR000651
DomainRASGEF_NTER

RAPGEF6 RAPGEF2

1.78e-0422172PS50212
DomainRASGEF_CAT

RAPGEF6 RAPGEF2

3.12e-0429172PS50009
DomainRasGEF

RAPGEF6 RAPGEF2

3.34e-0430172PF00617
Domain-

RAPGEF6 RAPGEF2

3.34e-04301721.10.840.10
DomainRas_GEF_dom

RAPGEF6 RAPGEF2

3.34e-0430172IPR023578
DomainRASGEF_cat_dom

RAPGEF6 RAPGEF2

3.34e-0430172IPR001895
DomainRasGEF

RAPGEF6 RAPGEF2

3.34e-0430172SM00147
DomainRA

RAPGEF6 RAPGEF2

3.57e-0431172SM00314
DomaincNMP

RAPGEF6 RAPGEF2

4.30e-0434172SM00100
DomaincNMP_binding

RAPGEF6 RAPGEF2

4.30e-0434172PF00027
DomaincNMP-bd_dom

RAPGEF6 RAPGEF2

4.56e-0435172IPR000595
DomainCNMP_BINDING_3

RAPGEF6 RAPGEF2

4.56e-0435172PS50042
DomainRA

RAPGEF6 RAPGEF2

4.82e-0436172PF00788
DomainRA

RAPGEF6 RAPGEF2

5.10e-0437172PS50200
DomaincNMP-bd-like

RAPGEF6 RAPGEF2

5.38e-0438172IPR018490
DomainRA_dom

RAPGEF6 RAPGEF2

5.96e-0440172IPR000159
Domain-

RAPGEF6 RAPGEF2

8.58e-04481722.60.120.10
DomainRmlC-like_jellyroll

RAPGEF6 RAPGEF2

9.68e-0451172IPR014710
DomainPDZ

RAPGEF6 RAPGEF2

7.15e-03141172PF00595
DomainPROTEIN_KINASE_ATP

JAK1 ULK3 LATS1

7.76e-03459173PS00107
DomainPDZ

RAPGEF6 RAPGEF2

7.85e-03148172SM00228
Domain-

RAPGEF6 RAPGEF2

8.05e-031501722.30.42.10
DomainPDZ

RAPGEF6 RAPGEF2

8.16e-03151172PS50106
DomainPDZ

RAPGEF6 RAPGEF2

8.26e-03152172IPR001478
DomainProt_kinase_dom

JAK1 ULK3 LATS1

9.23e-03489173IPR000719
DomainPROTEIN_KINASE_DOM

JAK1 ULK3 LATS1

9.44e-03493173PS50011
DomainKinase-like_dom

JAK1 ULK3 LATS1

1.22e-02542173IPR011009
Pubmed

Phosphatidic acid-dependent localization and basal de-phosphorylation of RA-GEFs regulate lymphocyte trafficking.

RAPGEF6 RAPGEF2

2.83e-07219232600317
Pubmed

The PDZ domain of the guanine nucleotide exchange factor PDZGEF directs binding to phosphatidic acid during brush border formation.

RAPGEF6 RAPGEF2

2.83e-07219224858808
Pubmed

Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain.

RAPGEF6 RAPGEF2

8.48e-07319229747665
Pubmed

Evolutionary and molecular facts link the WWC protein family to Hippo signaling.

LATS1 DLC1

7.90e-06819224682284
Pubmed

JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.

RAPGEF6 RAPGEF2

1.27e-051019223885123
Pubmed

Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response.

JAK1 UBE2G2

1.55e-051119224882218
Pubmed

OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ.

RAPGEF6 LATS1 RAPGEF2

1.63e-059119330472188
Pubmed

Crucial Role of Rapgef2 and Rapgef6, a Family of Guanine Nucleotide Exchange Factors for Rap1 Small GTPase, in Formation of Apical Surface Adherens Junctions and Neural Progenitor Development in the Mouse Cerebral Cortex.

RAPGEF6 RAPGEF2

2.20e-051319227390776
Pubmed

Rap2A links intestinal cell polarity to brush border formation.

RAPGEF6 RAPGEF2

2.96e-051519222797597
Pubmed

Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway.

RAPGEF6 LATS1

9.12e-052619228720576
Pubmed

Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966.

ZNF462 ACAN

1.86e-043719219266077
Pubmed

Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.

RAPGEF6 LATS1 RAPGEF2

4.09e-0427019324366813
GeneFamilyPDZ domain containing

RAPGEF6 RAPGEF2

4.39e-031521221220
CoexpressionGSE17974_CTRL_VS_ACT_IL4_AND_ANTI_IL12_72H_CD4_TCELL_UP

SLC7A6 LATS1 RAPGEF2 UBE2G2

1.05e-05195194M4201
ToppCellInt-URO-Lymphocyte-T_NK-NK_CD56bright|Int-URO / Disease, Lineage and Cell Type

JAK1 ZMAT4 TCEAL5

5.26e-0517419393c7acd5941a5f235ec4c57461f78ee2871e7336
ToppCellpdx-Tumor_cells-T6|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

SLC7A6 ZNF462 TMEM117

6.02e-051821937b24a4f712e1ae1525e8f1c8ec4e1fc43489cbee
ToppCell5'-GW_trimst-2-LymphNode-Mesenchymal-fibroblastic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DCAF12L1 ZMAT4 DLC1

7.16e-05193193c5bd0ed6f57459e54d2463318e8d9b1879718e63
ToppCell5'-GW_trimst-2-LymphNode-Mesenchymal|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DCAF12L1 ZMAT4 DLC1

7.61e-051971935fbbc570a4e77c703f569a4f85ce2d8af67d6297
ToppCellLPS-IL1RA-Endothelial-Epi-like|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ULK3 ACAN

1.10e-03116192cf4e3c34570f57502ec524881d351ef8e47976d2
ToppCelldroplet-Lung-30m-Hematologic-myeloid-intermediate_monocyte-intermediate_monocyte_l33|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLC7A6 RAPGEF2

1.50e-03136192a43b3db1754c619d328a26a2ba6af4756629a723
ToppCellSevere-Myeloid-Mast-|Severe / Condition, Lineage, Cell class and cell subclass

ZNF462 DLC1

1.70e-03145192ce307d45425a5191882078f049f85477eec40b69
ToppCellSevere-Myeloid-Mast|Severe / Condition, Lineage, Cell class and cell subclass

ZNF462 DLC1

1.70e-03145192e0bfd2ffdbd6c197ef0a04e983396ebd87ef7127
ToppCellURO-Lymphocyte-T_NK-NK_CD56bright|URO / Disease, Lineage and Cell Type

JAK1 ZMAT4

1.75e-03147192a6ca90e8dc37a016572ff68f34ab227b020eef70
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

CEP164 TMEM117

1.77e-03148192065177aaa63c0441d312260b43ecdac78c84ad03
ToppCellmild_COVID-19_(asymptomatic)-NK_CD56bright|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

ACAN ZMAT4

1.84e-031511922470162f4b56bc505db166a6eb0fa54847759df8
ToppCellmild_COVID-19_(asymptomatic)-NK_CD56bright|World / disease group, cell group and cell class (v2)

ACAN ZMAT4

1.89e-03153192aff5c8ab1fb4ebc324cec02cf562b7484bb10db8
ToppCellTCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Keratinizing_Cervical_Squamous_Cell_Carcinoma-3|TCGA-Cervix / Sample_Type by Project: Shred V9

RRAGC TMEM117

1.97e-03156192ffb9249a115ce31f50b99a7a3d40bf48b9d7f2b0
ToppCell10x3'2.3-week_12-13-Hematopoietic-HSC/MPP_and_pro-HSC/MPP|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

DCAF12L1 TCEAL5

1.97e-03156192bb2876bdf2375866d7509eba3c48322326349fa8
ToppCellLeuk-UTI-Lymphocyte-T_NK-NK_CD56bright|Leuk-UTI / Disease, Lineage and Cell Type

JAK1 ZMAT4

1.99e-03157192db0057741d06e212a9543cb4b011659b79efeafc
ToppCelldroplet-Lung-nan-3m-Lymphocytic-Proliferating_NK|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ULK3 RAPGEF2

2.01e-03158192ee8ce3cd202807df692b28bb1a81827d49d73862
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-3|TCGA-Skin / Sample_Type by Project: Shred V9

TMEM117 DLC1

2.04e-03159192fb222c42f66901852b01cec073ec0732245ee973
ToppCellCOVID-19_Moderate-MAIT|COVID-19_Moderate / disease group, cell group and cell class

ZNF462 TMEM117

2.04e-031591926d08d670c34eb6bb8ad5dad3293b3107c006236d
ToppCellCOVID-19_Moderate-MAIT|World / disease group, cell group and cell class

ZNF462 TMEM117

2.07e-03160192bf73c5fe87c1f243edec17d7a2c30fae5e2cfd6b
ToppCellPND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TMEM117 TCEAL5

2.07e-031601928624f101828efd32cdd38a65df8d94d690720a63
ToppCellPND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

TMEM117 TCEAL5

2.07e-031601929de3dd6b9d4b51314d60b3b01f4132bcfa2dfc18
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ULK3 RAPGEF2

2.09e-03161192334f540dff3508d451e5e85e8e4e8f3b8d6b74e7
ToppCellIIF-Lymphocyte-T_NK-NK_CD56bright|IIF / Disease, Lineage and Cell Type

JAK1 ZMAT4

2.09e-03161192b1bd1074ecba4cf171d748e2f686e9a99c0f0e89
ToppCellfacs-Marrow-B-cells-3m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ULK3 RAPGEF2

2.09e-0316119281d44438e4be4e68a59247e62f02026301a8a0c5
ToppCell3'-Adult-SmallIntestine-Epithelial-mature_enterocytic-Paneth|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNF462 ERMARD

2.12e-03162192768a566e76923323c1f197f60bab472a8784490b
ToppCelldroplet-Lung-LUNG-1m-Lymphocytic-NK_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAK1 UBE2G2

2.14e-03163192a0315855c354e830e109d41bd6e3396488aa8de9
ToppCellMultiple_Sclerosis-Lymphocyte-T_NK-NK_CD56bright|Multiple_Sclerosis / Disease, Lineage and Cell Type

JAK1 ZMAT4

2.14e-0316319282c4b25f05bd404fdee9aa90f23efd6dffc04e7b
ToppCellControl-MAIT|World / Disease group and Cell class

RAPGEF6 TMEM117

2.14e-031631920ca4b835936b4f82217cbe57210c1dd90986c1d0
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZMAT4 TMEM117

2.17e-03164192b6beb8548ac0dd07e8a580a938e5ee4bf25a3c1f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Degenerative_Cortical_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DCAF12L1 TMEM117

2.17e-0316419283141be8dfed85511ea6afda7c76ff4b6b5ef021
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Serous_adenocarcinoma|TCGA-Endometrium / Sample_Type by Project: Shred V9

DCAF12L1 TCEAL5

2.17e-0316419208c725548e751f815b4df778607270498204b353
ToppCelldroplet-Lung-LUNG-1m-Lymphocytic-Natural_Killer|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAK1 UBE2G2

2.17e-03164192a59078c8f88e416e940c9b15151ce7de1bbe987e
ToppCellnormal-na-Lymphocytic_NK-NK_bright-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

JAK1 ZMAT4

2.17e-03164192b5a91f2cbfad9a2bc38aea576085a37865df955d
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZMAT4 TMEM117

2.17e-03164192fe11fcce4ba7f44ba2989ea3705916b67e75f8e7
ToppCellHealthy-NK_CD56bright|Healthy / disease group, cell group and cell class

JAK1 ZMAT4

2.17e-03164192ed193211965accba60a256d3e6c159f0fc911d8b
ToppCellLV-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

ACAN DLC1

2.19e-03165192f37fd95adc95d7753cf6e55ae819976513c7ec77
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte-Chondrocyte_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZNF462 ACAN

2.22e-0316619237794a84601a2a949d579663d4a4bb8bc8fb5923
ToppCell10x5'-bone_marrow-Hematopoietic_progenitors-Progenitor_Erythro-Mega|bone_marrow / Manually curated celltypes from each tissue

TCEAL5 DLC1

2.22e-03166192a853005a5587d42daecdf2e23a93109919021a4f
ToppCellPND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ZNF462 ACAN

2.22e-0316619281c546c6d847e49e662b81e71992ca0f7a99e890
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAK1 RAPGEF6

2.25e-03167192d72b08b3cbc34b30a11dcf512e472b64d1606ec1
ToppCell10x5'v1-week_14-16-Hematopoietic-HSC/MPP_and_pro-HSC/MPP|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

DCAF12L1 TCEAL5

2.25e-03167192d041b345014e170e9a45f8c6ef8a37ff56f14750
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ACAN RAPGEF6

2.25e-031671924e58f9bf1e9d47720c871776ec34513ded4de9b7
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ACAN RAPGEF6

2.25e-031671924ae9f2c5df13463709ea880ab035965fd99e7626
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAK1 RAPGEF6

2.25e-0316719222f7384ff2044898d7b0b01cb9d9a3cbaa93a9a3
ToppCellHealthy-NK_CD56bright|World / disease group, cell group and cell class

JAK1 ZMAT4

2.25e-03167192ab7a570a75ee2018b9fe886cdec79cda27f1563f
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

SLC7A6 RAPGEF6

2.25e-03167192ced6ed9b412739c6ced622523347c10295edbf53
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-Macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF462 GAL3ST2

2.30e-03169192780fb0050852626062a729dd1b82b0cf61e7e9ca
ToppCelldroplet-Thymus-nan-18m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAK1 RAPGEF6

2.33e-0317019290f7640f04672c800cb28aea50004b1bb0565e8a
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l9|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

JAK1 RAPGEF6

2.33e-031701928e9b5f7bfb61f8d84d0b17fb0c191da4dabad63d
ToppCellCOVID-19_Moderate-NK_CD56bright|World / disease group, cell group and cell class

JAK1 ZMAT4

2.33e-03170192caa6a534c1e9639caced9a51680f5c905f061bcc
ToppCell3'-GW_trimst-1-SmallIntestine-Mesenchymal-Pericytes-angiogenic_pericyte|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ACAN DLC1

2.33e-03170192d9ed257d0938442d0bb280e4c4b0c9b657511b46
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ACAN DLC1

2.35e-03171192b0373ed8283ee1792b6a490bff93906546978593
ToppCelldroplet-Thymus-nan-18m-Lymphocytic-DN4|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAK1 RAPGEF6

2.35e-03171192f08402d0f42822c35673522043b652f8fb68d2f6
ToppCell3'_v3-lymph-node_spleen-Hematopoietic_progenitors-Progenitor_Erythro-Mega|lymph-node_spleen / Manually curated celltypes from each tissue

TCEAL5 DLC1

2.35e-031711923ecd0a074344179c57eb2d9a857ba594904d00fa
ToppCellControl-Myeloid-Mast|World / Disease state, Lineage and Cell class

ZNF462 RAPGEF2

2.35e-03171192ed8e61d524f4cddc6084b261175df54d2a64a60f
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ACAN DLC1

2.35e-03171192b92963f9f247d2e5e2e6c51c6dbf70e527cd2f55
ToppCellLV-13._Vascular_Smooth_Muscle|LV / Chamber and Cluster_Paper

ACAN DLC1

2.35e-03171192e99ecae66530d1ae09330cee408c8f3950b87e67
ToppCellHealthy/Control-NK_CD56bright|World / Disease group and Cell class

JAK1 ZMAT4

2.35e-0317119279d7efefdae267905af05f3001514b8b6934d86e
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ULK3 RAPGEF2

2.38e-03172192a9e13aa36087170dadca421ba9de588e5a1cf715
ToppCellControl-MAIT|Control / Disease group and Cell class

RAPGEF6 TMEM117

2.38e-03172192552bc62e8e8bb0ac1cd0452f4410a3af087787eb
ToppCellnormal_Lung-T/NK_cells-CD8+/CD4+_Mixed_Th|T/NK_cells / Location, Cell class and cell subclass

SLC7A6 RAPGEF2

2.38e-031721920657c736f3c52d25cf7f652eac005ddcde9232ef
ToppCellfacs-Trachea-nan-24m-Mesenchymal-chondrocyte|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DCAF12L1 ACAN

2.41e-031731922226505610af1becc253d0a5550627144ef0ed6b
ToppCellCOVID-19_Moderate-NK_CD56bright|COVID-19_Moderate / disease group, cell group and cell class

JAK1 ZMAT4

2.41e-03173192a07dcb1e555caaa2235aec219334fcbf2d07f10c
ToppCell10x5'-GI_small-bowel-Mast|GI_small-bowel / Manually curated celltypes from each tissue

ZNF462 DLC1

2.44e-03174192e94c980b25edfd0e8598c416828801fcc00e8ead
ToppCellHealthy/Control-NK_CD56bright|Healthy/Control / Disease group and Cell class

JAK1 ZMAT4

2.44e-03174192f53f675c8cb14294ac526dcc3dca4f08288f8473
ToppCell10x5'-GI_small-bowel-Mast-Mast_cells|GI_small-bowel / Manually curated celltypes from each tissue

ZNF462 DLC1

2.44e-0317419205525bf0a2bde2be4f7c147b17a24530ce8819e0
ToppCellsevere_COVID-19-HSPC|severe_COVID-19 / disease group, cell group and cell class (v2)

ZNF462 TCEAL5

2.44e-031741926d35bacf073537b272ff821e604c899fb9ce6a7c
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_CD56bright-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

JAK1 ZMAT4

2.46e-031751920ed053aa8353c72ff37fee830672704a3ddc7d85
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DCAF12L1 ACAN

2.46e-03175192f1394aacc8a94ca555dd19aaed5a18da99c6bf40
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SLC7A6 DLC1

2.46e-03175192910a075ccaf79de22338ecf321fa0a867f3d7d75
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

ULK3 RAPGEF2

2.46e-03175192f3a68aeb79c4935006e17a5ff3445a8ec0e33f5f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SLC7A6 DLC1

2.46e-03175192f0c2eb82e17e8aec2cfa5d83169178f409cc1abc
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DCAF12L1 ACAN

2.46e-031751927bf1194d93fbe2dbf9d953e0a32b2a6d88251ed1
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_CD56bright|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

JAK1 ZMAT4

2.46e-03175192e219b61d6bc078d44ea7d06191d3462654d857a1
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DCAF12L1 RAPGEF2

2.46e-031751923e56695a9db97cb1d3503425c48eb79bbf99213e
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_CD56bright|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

JAK1 ZMAT4

2.46e-031751920124a3c4696b39cee8b566e94603d1d3d128bfa5
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

JAK1 RAPGEF6

2.46e-03175192f949613ee45f5d950578c512d197716855118d18
ToppCellPBMC-Severe-Lymphocyte-T/NK-NK_cell-NK_CD56bright-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

JAK1 ZMAT4

2.46e-03175192bd16c80418bf71127e6f1e50edf83967c9218b42
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l34|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DCAF12L1 ACAN

2.49e-0317619277c3da2eaa072a6baefb5087fd07ec18c5e271cd
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-Pericytes-angiogenic_pericyte|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ACAN DLC1

2.49e-031761928b5c2fb7e5e551df658b1d5fc7f607a27bab00d5
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

JAK1 RAPGEF6

2.52e-0317719213f22e578728be477b097889af483b1e3f3e18bb
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

JAK1 RAPGEF6

2.52e-03177192c840efec4eba746543eac0f48dd688518f0fb5f0
ToppCellcontrol-NK_CD56bright|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

JAK1 ZMAT4

2.55e-03178192f3d0bc9a39ed94785676f10c285c5b031bc93aae
ToppCelldroplet-Fat-Scat-21m-Mesenchymal-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM117 GAL3ST2

2.55e-031781925fc9f41609735b972a2cd0830182d13742cd5bf5
ToppCelldroplet-Thymus-nan-24m-Lymphocytic-Double_negative_Thymocyte,_DN4_(Cd8-,_Cd4-),_some_undergoing_VDJ_recombination_|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF462 LATS1

2.55e-03178192408e41c853f608965cef9111fb87fdc311cdc7a8
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

JAK1 RAPGEF6

2.55e-03178192934a2a7b35a23b56e34d4d0ef68c271513ef1fe9
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAK1 RAPGEF6

2.55e-031781924112ac058e18dedb60e248ca43352fd43f54e77a
ToppCell356C-Lymphocytic-NK_cells-NK_cell_C|356C / Donor, Lineage, Cell class and subclass (all cells)

JAK1 ZMAT4

2.55e-031781927203149864cc8d5ae25329fdbf15c6b73c3d3595
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-CD8+_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAK1 RAPGEF6

2.55e-03178192b2bd45f2fee0b4f7cb9fb7c74109f948d0581785
ToppCellPBMC-Mild-Hematopoietic-HSPC|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TCEAL5 DLC1

2.57e-031791922f690f933bf6b99abeb31766e0b22bdbe36c1ba0
ToppCellCOVID-19_Mild-Hematopoietic_SC-HSPC|COVID-19_Mild / Disease group, lineage and cell class

TCEAL5 DLC1

2.57e-0317919219fcf48f5e02e4cb2b328efb4502f337e1282f72
ToppCellPBMC-Mild-Hematopoietic-HSPC-HSPC-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TCEAL5 DLC1

2.57e-031791924bb2debfc9e9f258cd38e797ef160bd440aad6af
ToppCelldroplet-Kidney-nan-21m-Endothelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DCAF12L1 DLC1

2.57e-03179192ba38177ffcf3a20f02afeeaaa91bc8eab8d1ac05
ToppCellPBMC-Mild-Hematopoietic-HSPC-HSPC|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TCEAL5 DLC1

2.57e-031791923e2c937369b8190fd5d5a31689d029e6e89fb5e2
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

JAK1 RAPGEF6

2.57e-031791921309d41dbf286e9230fde6a7949e60c24d86766a
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

JAK1 RAPGEF6

2.57e-031791928498f94202434b3cb5d84f1a37d3ad191baf664e
ToppCelldroplet-Kidney-nan-21m-Endothelial-kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DCAF12L1 DLC1

2.57e-03179192d121351b4c3b91108e6c5753d18a44d676f38d4c
ToppCellCOVID-19_Mild-Hematopoietic_SC|COVID-19_Mild / Disease group, lineage and cell class

TCEAL5 DLC1

2.57e-0317919250a073166e34bcfa52a62c4dafb3aef724e0fa8e
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_CPZ|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DCAF12L1 DLC1

2.60e-03180192a499548391e6833b78f6e920f8e32a755814a9da
ToppCellfacs-Lung-EPCAM-24m-Myeloid-Dendritic_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMEM117 GAL3ST2

2.60e-031801925b7d2336ed09d07f6b8dd91c1fa9c5ade633c104
Diseasechildhood aggressive behaviour measurement

TMEM207 DLC1

1.33e-0389182EFO_0007663
Diseasecolorectal cancer (is_implicated_in)

JAK1 DLC1

2.44e-03121182DOID:9256 (is_implicated_in)
DiseaseBMI-adjusted waist circumference, physical activity measurement

ZNF462 ACAN

2.52e-03123182EFO_0007789, EFO_0008002
Diseasesexual dimorphism measurement

ZNF462 ACAN CEP164 RAPGEF6

3.94e-031106184EFO_0021796
Diseasehepatocellular carcinoma (is_implicated_in)

JAK1 CEP164

5.37e-03181182DOID:684 (is_implicated_in)
Diseasebody surface area

ZNF462 ACAN DLC1

6.58e-03643183EFO_0022196
Diseasediastolic blood pressure, systolic blood pressure

ACAN CEP164 DLC1

7.37e-03670183EFO_0006335, EFO_0006336
DiseaseAbnormality of refraction

ZNF462 ZMAT4 DLC1

7.47e-03673183HP_0000539
Diseaseopioid dependence

TMEM207 DLC1

9.03e-03237182EFO_0005611

Protein segments in the cluster

PeptideGeneStartEntry
ENEMNWFHSNDGGNV

JAK1

296

P23458
DHPRQDSMDFSNEWG

LATS1

866

O95835
GDFRWSDGHPMQFEN

ACAN

2386

P16112
NNMWFDFGFDPNAQC

GAL3ST2

191

Q9H3Q3
LNHNDFWVNYFGGME

DCAF12L1

411

Q5VU92
PAMEFLWDFLNHQEG

ERMARD

351

Q5T6L9
NFQIWDFPGQMDFFD

RRAGC

111

Q9HB90
WVNNHFNDFEGDPAM

RAPGEF6

481

Q8TEU7
HWMGQPFNSDDRNTA

DLC1

16

Q96QB1
NFANGQSMWDHPCDE

CEP164

76

Q9UPV0
WVNNHFNDFEGDPAM

RAPGEF2

336

Q9Y4G8
GGFHWMQRDVQDPFA

TCEAL5

166

Q5H9L2
HFQDAFEGSSWDMGN

SLC7A6

221

Q92536
NHYQAFHPWAMNGDE

ZNF462

1386

Q96JM2
QDWEFPHFMGDVDVN

TMEM117

256

Q9H0C3
DEMCVNYNDQHPNGW

TMEM207

36

Q6UWW9
AAWFNNPLMAQQHYD

ZMAT4

151

Q9H898
ADFGFAQHMSPWDEK

ULK3

156

Q6PHR2
AGPMNEENFFEWEAL

UBE2G2

26

P60604