Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	complement component C3b binding	CFHR1 CFHR2 CFHR5	1.43e-05	12	82	3	GO:0001851
GeneOntologyMolecularFunction	opsonin binding	CFHR1 CFHR2 CFHR5	1.44e-04	25	82	3	GO:0001846
GeneOntologyMolecularFunction	complement binding	CFHR1 CFHR2 CFHR5	3.04e-04	32	82	3	GO:0001848
GeneOntologyMolecularFunction	neuropeptide binding	MRGPRX1 MRGPRX3 MRGPRX4	4.69e-04	37	82	3	GO:0042923
GeneOntologyBiologicalProcess	response to chloroquine	MRGPRX1 MRGPRX3 MRGPRX4	5.59e-07	5	80	3	GO:1902349
GeneOntologyBiologicalProcess	cytolysis by host of symbiont cells	CFHR1 CFHR2 CFHR5	6.61e-06	10	80	3	GO:0051838
GeneOntologyBiologicalProcess	regulation of cytokinesis	MRGPRX1 MRGPRX3 MRGPRX4 RXFP3 BIRC6	4.16e-05	99	80	5	GO:0032465
GeneOntologyBiologicalProcess	positive regulation of cytokinesis	MRGPRX1 MRGPRX3 MRGPRX4 RXFP3	6.16e-05	55	80	4	GO:0032467
GeneOntologyBiologicalProcess	regulation of cell cycle process	MBTPS1 CTC1 CCNE2 MRGPRX1 PKHD1 MRGPRX3 MRGPRX4 PRKDC RXFP3 INTS3 BIRC6 NPM2	9.60e-05	845	80	12	GO:0010564
GeneOntologyBiologicalProcess	cytokinesis	ORC4 MRGPRX1 MRGPRX3 MRGPRX4 RXFP3 BIRC6	1.42e-04	204	80	6	GO:0000910
GeneOntologyBiologicalProcess	negative regulation of phagocytosis, engulfment	SIGLEC12 SIGLEC7	1.47e-04	5	80	2	GO:0060101
GeneOntologyBiologicalProcess	biological process involved in interaction with symbiont	CFHR1 CFHR2 CFHR5 PLG MUC2	1.81e-04	135	80	5	GO:0051702
GeneOntologyBiologicalProcess	negative regulation of membrane invagination	SIGLEC12 SIGLEC7	2.21e-04	6	80	2	GO:1905154
GeneOntologyBiologicalProcess	chemosensory behavior	MRGPRX1 MRGPRX3 MRGPRX4	2.34e-04	31	80	3	GO:0007635
MousePheno	decreased pruritus	MRGPRX1 MRGPRX3 MRGPRX4	3.80e-06	7	68	3	MP:0010073
MousePheno	abnormal pruritus	MRGPRX1 MRGPRX3 MRGPRX4	2.35e-05	12	68	3	MP:0010071
Domain	MRGPCRFAMILY	MRGPRX1 MRGPRX3 MRGPRX4	1.31e-05	11	82	3	IPR026234
Domain	Sushi	CFHR1 CFHR2 CFHR5 CSMD3	7.96e-05	52	82	4	PF00084
Domain	CCP	CFHR1 CFHR2 CFHR5 CSMD3	9.24e-05	54	82	4	SM00032
Domain	SUSHI	CFHR1 CFHR2 CFHR5 CSMD3	1.07e-04	56	82	4	PS50923
Domain	Sushi_SCR_CCP_dom	CFHR1 CFHR2 CFHR5 CSMD3	1.14e-04	57	82	4	IPR000436
Domain	FATC	SMG1 PRKDC	1.89e-04	5	82	2	PF02260
Domain	FAT	SMG1 PRKDC	2.82e-04	6	82	2	PS51189
Domain	FATC	SMG1 PRKDC	2.82e-04	6	82	2	PS51190
Domain	FATC_dom	SMG1 PRKDC	2.82e-04	6	82	2	IPR003152
Domain	PIK_FAT	SMG1 PRKDC	2.82e-04	6	82	2	IPR014009
Domain	FATC	SMG1 PRKDC	2.82e-04	6	82	2	SM01343
Domain	-	CNTNAP2 HERC2 SUCO SSPOP	2.98e-04	73	82	4	2.60.120.260
Domain	-	SIGLEC12 LSR CD1D SIGLEC7 NXPE4 PKHD1 IGSF1 LRRC4 CD300E GPA33	6.35e-04	663	82	10	2.60.40.10
Domain	Galactose-bd-like	CNTNAP2 HERC2 SUCO SSPOP	7.80e-04	94	82	4	IPR008979
Domain	Ig-like_fold	SIGLEC12 LSR CD1D SIGLEC7 NXPE4 PKHD1 IGSF1 LRRC4 CD300E GPA33	1.03e-03	706	82	10	IPR013783
Domain	TIL	MUC2 SSPOP	1.22e-03	12	82	2	PF01826
Domain	C8	MUC2 SSPOP	1.22e-03	12	82	2	PF08742
Domain	IG_LIKE	SIGLEC12 LSR CD1D SIGLEC7 IGSF1 LRRC4 CD300E GPA33	1.40e-03	491	82	8	PS50835
Domain	Unchr_dom_Cys-rich	MUC2 SSPOP	1.44e-03	13	82	2	IPR014853
Domain	C8	MUC2 SSPOP	1.44e-03	13	82	2	SM00832
Domain	ig	SIGLEC12 SIGLEC7 IGSF1 LRRC4 GPA33	1.50e-03	190	82	5	PF00047
Domain	Immunoglobulin	SIGLEC12 SIGLEC7 IGSF1 LRRC4 GPA33	1.50e-03	190	82	5	IPR013151
Domain	Ig-like_dom	SIGLEC12 LSR CD1D SIGLEC7 IGSF1 LRRC4 CD300E GPA33	1.63e-03	503	82	8	IPR007110
Domain	TIL_dom	MUC2 SSPOP	1.67e-03	14	82	2	IPR002919
Domain	PI3/4_kinase_CS	SMG1 PRKDC	1.93e-03	15	82	2	IPR018936
Domain	VWD	MUC2 SSPOP	2.20e-03	16	82	2	SM00216
Domain	VWF_type-D	MUC2 SSPOP	2.20e-03	16	82	2	IPR001846
Domain	-	SMG1 PRKDC	2.20e-03	16	82	2	1.10.1070.11
Domain	VWFD	MUC2 SSPOP	2.20e-03	16	82	2	PS51233
Domain	PI3Kc	SMG1 PRKDC	2.20e-03	16	82	2	SM00146
Domain	VWD	MUC2 SSPOP	2.20e-03	16	82	2	PF00094
Domain	IG	SIGLEC12 LSR SIGLEC7 IGSF1 LRRC4 CD300E GPA33	2.50e-03	421	82	7	SM00409
Domain	Ig_sub	SIGLEC12 LSR SIGLEC7 IGSF1 LRRC4 CD300E GPA33	2.50e-03	421	82	7	IPR003599
Domain	PI3/4_kinase_cat_dom	SMG1 PRKDC	2.78e-03	18	82	2	IPR000403
Domain	ZZ	HERC2 UTRN	2.78e-03	18	82	2	PF00569
Domain	PI3_PI4_kinase	SMG1 PRKDC	2.78e-03	18	82	2	PF00454
Domain	PI3_4_KINASE_3	SMG1 PRKDC	2.78e-03	18	82	2	PS50290
Domain	ZF_ZZ_2	HERC2 UTRN	2.78e-03	18	82	2	PS50135
Domain	CTCK_1	MUC2 SSPOP	2.78e-03	18	82	2	PS01185
Domain	PI3_4_KINASE_1	SMG1 PRKDC	2.78e-03	18	82	2	PS00915
Domain	PI3_4_KINASE_2	SMG1 PRKDC	2.78e-03	18	82	2	PS00916
Domain	ZF_ZZ_1	HERC2 UTRN	2.78e-03	18	82	2	PS01357
Domain	VWC_out	MUC2 SSPOP	3.10e-03	19	82	2	SM00215
Domain	Znf_ZZ	HERC2 UTRN	3.10e-03	19	82	2	IPR000433
Domain	ZnF_ZZ	HERC2 UTRN	3.10e-03	19	82	2	SM00291
Domain	IGc2	SIGLEC12 SIGLEC7 IGSF1 LRRC4 GPA33	3.76e-03	235	82	5	SM00408
Domain	Ig_sub2	SIGLEC12 SIGLEC7 IGSF1 LRRC4 GPA33	3.76e-03	235	82	5	IPR003598
Domain	FA58C	CNTNAP2 SSPOP	3.79e-03	21	82	2	SM00231
Domain	FA58C_3	CNTNAP2 SSPOP	3.79e-03	21	82	2	PS50022
Domain	FA58C_1	CNTNAP2 SSPOP	3.79e-03	21	82	2	PS01285
Domain	FA58C_2	CNTNAP2 SSPOP	3.79e-03	21	82	2	PS01286
Domain	F5_F8_type_C	CNTNAP2 SSPOP	4.94e-03	24	82	2	PF00754
Domain	FA58C	CNTNAP2 SSPOP	4.94e-03	24	82	2	IPR000421
Domain	Cys_knot_C	MUC2 SSPOP	5.35e-03	25	82	2	IPR006207
Domain	CTCK_2	MUC2 SSPOP	5.35e-03	25	82	2	PS01225
Pathway	KEGG_MEDICUS_REFERENCE_REGULATION_OF_COMPLEMENT_CASCADE_CFHR	CFHR1 CFHR2 CFHR5	1.53e-06	6	61	3	M47880
Pubmed	Activation of mas-related G-protein-coupled receptors by the house dust mite cysteine protease Der p1 provides a new mechanism linking allergy and inflammation.	MRGPRX1 MRGPRX3 MRGPRX4	1.41e-08	3	85	3	28768771
Pubmed	The inhibition of high-voltage-activated calcium current by activation of MrgC11 involves phospholipase C-dependent mechanisms.	MRGPRX1 MRGPRX3 MRGPRX4	1.41e-08	3	85	3	26022362
Pubmed	Investigating the role of MRGPRC11 and capsaicin-sensitive afferent nerves in the anti-influenza effects exerted by SLIGRL-amide in murine airways.	MRGPRX1 MRGPRX3 MRGPRX4	1.41e-08	3	85	3	27215903
Pubmed	Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs.	MRGPRX1 MRGPRX3 MRGPRX4	1.41e-08	3	85	3	11850634
Pubmed	bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells.	MRGPRX1 MRGPRX3 MRGPRX4	1.41e-08	3	85	3	10662793
Pubmed	Agonists of the MAS-related gene (Mrgs) orphan receptors as novel mediators of mast cell-sensory nerve interactions.	MRGPRX1 MRGPRX3 MRGPRX4	1.41e-08	3	85	3	18250432
Pubmed	Mas-related G protein-coupled receptor C11 (Mrgprc11) induces visceral hypersensitivity in the mouse colon: A novel target in gut nociception?	MRGPRX1 MRGPRX3 MRGPRX4	1.41e-08	3	85	3	31119828
Pubmed	C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation.	CFHR1 CFHR2 CFHR5	1.41e-08	3	85	3	23728178
Pubmed	MrgprA3 shows sensitization to chloroquine in an acetone-ether-water mice model.	MRGPRX1 MRGPRX3 MRGPRX4	5.63e-08	4	85	3	29064954
Pubmed	Activation of MrgprA3 and MrgprC11 on Bladder-Innervating Afferents Induces Peripheral and Central Hypersensitivity to Bladder Distension.	MRGPRX1 MRGPRX3 MRGPRX4	5.63e-08	4	85	3	33727332
Pubmed	A fraction of mouse sperm chromatin is organized in nucleosomal hypersensitive domains enriched in retroposon DNA.	MRGPRX1 MRGPRX3 MRGPRX4	5.63e-08	4	85	3	10504302
Pubmed	A mechanically activated ion channel is functionally expressed in the MrgprB4 positive sensory neurons, which detect stroking of hairy skin in mice.	MRGPRX1 MRGPRX3 MRGPRX4	5.63e-08	4	85	3	28545921
Pubmed	Substance P activates Mas-related G protein-coupled receptors to induce itch.	MRGPRX1 MRGPRX3 MRGPRX4	5.63e-08	4	85	3	28219706
Pubmed	Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection.	MRGPRX1 MRGPRX3 MRGPRX4	5.63e-08	4	85	3	35882236
Pubmed	Molecular Signature of Pruriceptive MrgprA3+ Neurons.	MRGPRX1 MRGPRX3 MRGPRX4	5.63e-08	4	85	3	32234460
Pubmed	Overlap of direct and indirect alloreactive T-cell repertoires when MHC polymorphism is limited to the peptide binding groove.	MRGPRX1 MRGPRX3 MRGPRX4	5.63e-08	4	85	3	11821156
Pubmed	Cloning and functional expression of a novel Gi protein-coupled receptor for adenine from mouse brain.	MRGPRX1 MRGPRX3 MRGPRX4	5.63e-08	4	85	3	17975009
Pubmed	Human sensory neuron-specific Mas-related G protein-coupled receptors-X1 sensitize and directly activate transient receptor potential cation channel V1 via distinct signaling pathways.	MRGPRX1 MRGPRX3 MRGPRX4	5.63e-08	4	85	3	23074220
Pubmed	Characterization of new G protein-coupled adenine receptors in mouse and hamster.	MRGPRX1 MRGPRX3 MRGPRX4	5.63e-08	4	85	3	23608776
Pubmed	The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia.	MRGPRX1 MRGPRX3 MRGPRX4	5.63e-08	4	85	3	21775281
Pubmed	Voltage-gated potassium channels involved in regulation of physiological function in MrgprA3-specific itch neurons.	MRGPRX1 MRGPRX3 MRGPRX4	5.63e-08	4	85	3	26874069
Pubmed	Tick peptides evoke itch by activating MrgprC11/MRGPRX1 to sensitize TRPV1 in pruriceptors.	MRGPRX1 MRGPRX3 MRGPRX4	5.63e-08	4	85	3	33358893
Pubmed	USP48 alleviates bone cancer pain and regulates MrgC stabilization in spinal cord neurons of male mice.	MRGPRX1 MRGPRX3 MRGPRX4	5.63e-08	4	85	3	36864656
Pubmed	Low maternal care enhances the skin barrier resistance of offspring in mice.	MRGPRX1 MRGPRX3 MRGPRX4	5.63e-08	4	85	3	31295326
Pubmed	Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus.	MRGPRX1 MRGPRX3 MRGPRX4	1.40e-07	5	85	3	20004959
Pubmed	Factor H-related proteins determine complement-activating surfaces.	CFHR1 CFHR2 CFHR5	1.40e-07	5	85	3	25979655
Pubmed	Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch.	MRGPRX1 MRGPRX3 MRGPRX4	1.40e-07	5	85	3	17618277
Pubmed	Hippocampal short- and long-term plasticity are not modulated by astrocyte Ca2+ signaling.	MRGPRX1 MRGPRX3 MRGPRX4	1.40e-07	5	85	3	20203048
Pubmed	Regional Differences in Itch Transmission.	MRGPRX1 MRGPRX3 MRGPRX4	1.40e-07	5	85	3	38735364
Pubmed	MrgprB4 in trigeminal neurons expressing TRPA1 modulates unpleasant sensations.	MRGPRX1 MRGPRX3 MRGPRX4	1.40e-07	5	85	3	34116733
Pubmed	Astrocytes modulate neural network activity by Ca²+-dependent uptake of extracellular K+.	MRGPRX1 MRGPRX3 MRGPRX4	1.40e-07	5	85	3	22472648
Pubmed	Cross-sensitization of histamine-independent itch in mouse primary sensory neurons.	MRGPRX1 MRGPRX3 MRGPRX4	1.40e-07	5	85	3	23000623
Pubmed	ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons.	MRGPRX1 TRPV2 MRGPRX3 MRGPRX4	1.93e-07	21	85	4	25369838
Pubmed	Dimerization of complement factor H-related proteins modulates complement activation in vivo.	CFHR1 CFHR2 CFHR5	2.80e-07	6	85	3	23487775
Pubmed	A subpopulation of nociceptors specifically linked to itch.	MRGPRX1 MRGPRX3 MRGPRX4	2.80e-07	6	85	3	23263443
Pubmed	Sequence and Expression of Complement Factor H Gene Cluster Variants and Their Roles in Age-Related Macular Degeneration Risk.	CFHR1 CFHR2 CFHR5	2.80e-07	6	85	3	27196323
Pubmed	Visualizing the Itch-Sensing Skin Arbors.	MRGPRX1 MRGPRX3 MRGPRX4	2.80e-07	6	85	3	33091423
Pubmed	Genetic identification of C fibres that detect massage-like stroking of hairy skin in vivo.	MRGPRX1 MRGPRX3 MRGPRX4	2.80e-07	6	85	3	23364746
Pubmed	Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications.	CFHR1 CFHR2 CFHR5	2.80e-07	6	85	3	17438673
Pubmed	Identification of a bilirubin receptor that may mediate a component of cholestatic itch.	MRGPRX1 MRGPRX3 MRGPRX4	2.80e-07	6	85	3	30657454
Pubmed	Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain.	MRGPRX1 MRGPRX3 MRGPRX4	2.80e-07	6	85	3	24549959
Pubmed	Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs.	MRGPRX1 MRGPRX3 MRGPRX4	2.80e-07	6	85	3	26216096
Pubmed	MrgprC11+ sensory neurons mediate glabrous skin itch.	MRGPRX1 MRGPRX3 MRGPRX4	2.80e-07	6	85	3	33876765
Pubmed	Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain.	MRGPRX1 TRPV2 MRGPRX3 MRGPRX4	2.84e-07	23	85	4	16446141
Pubmed	Touch neurons underlying dopaminergic pleasurable touch and sexual receptivity.	MRGPRX1 MRGPRX3 MRGPRX4	4.90e-07	7	85	3	36693373
Pubmed	Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes.	MRGPRX1 MRGPRX3 MRGPRX4	7.82e-07	8	85	3	24583173
Pubmed	Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family.	MRGPRX1 MRGPRX3 MRGPRX4	7.82e-07	8	85	3	12909716
Pubmed	Epidemiological approach to identifying genetic predispositions for atypical hemolytic uremic syndrome.	CFHR1 CFHR2 CFHR5	1.17e-06	9	85	3	20059470
Pubmed	Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway.	MRGPRX1 MRGPRX3 MRGPRX4	1.17e-06	9	85	3	12397184
Pubmed	Multiplexed peroxidase-based electron microscopy labeling enables simultaneous visualization of multiple cell types.	MRGPRX1 MRGPRX3 MRGPRX4	1.17e-06	9	85	3	30886406
Pubmed	Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens.	MRGPRX1 MRGPRX3 MRGPRX4	1.67e-06	10	85	3	33098765
Pubmed	A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons.	MRGPRX1 MRGPRX3 MRGPRX4	2.29e-06	11	85	3	11551509
Pubmed	An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates.	MRGPRX1 MRGPRX3 MRGPRX4	2.29e-06	11	85	3	21151121
Pubmed	Parallel ascending spinal pathways for affective touch and pain.	MRGPRX1 MRGPRX3 MRGPRX4	5.03e-06	14	85	3	33116307
Pubmed	Deficiency of Mouse FHR-1 Homolog, FHR-E, Accelerates Sepsis, and Acute Kidney Injury Through Enhancing the LPS-Induced Alternative Complement Pathway.	CFHR1 CFHR2	5.90e-06	2	85	2	32636836
Pubmed	Common haplotypes at the CFH locus and low-frequency variants in CFHR2 and CFHR5 associate with systemic FHR concentrations and age-related macular degeneration.	CFHR2 CFHR5	5.90e-06	2	85	2	34260947
Pubmed	Molecular cloning of a human serum protein structurally related to complement factor H.	CFHR1 CFHR2	5.90e-06	2	85	2	1711047
Pubmed	Molecular bases for the association of FHR-1 with atypical hemolytic uremic syndrome and other diseases.	CFHR1 CFHR2	5.90e-06	2	85	2	33651882
Pubmed	Complement factor H-related hybrid protein deregulates complement in dense deposit disease.	CFHR2 CFHR5	5.90e-06	2	85	2	24334459
Pubmed	Complement Factor H-Related Proteins FHR1 and FHR5 Interact With Extracellular Matrix Ligands, Reduce Factor H Regulatory Activity and Enhance Complement Activation.	CFHR1 CFHR5	5.90e-06	2	85	2	35392081
Pubmed	L-fucose reduces gut inflammation due to T-regulatory response in Muc2 null mice.	PRKDC MUC2	5.90e-06	2	85	2	36584066
Pubmed	Circulating complement factor H-related proteins 1 and 5 correlate with disease activity in IgA nephropathy.	CFHR1 CFHR5	5.90e-06	2	85	2	28673452
Pubmed	Intragenic motifs regulate the transcriptional complexity of Pkhd1/PKHD1.	PKHD1 PRKDC	5.90e-06	2	85	2	24984783
Pubmed	Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2.	MBTPS1 SREBF2	5.90e-06	2	85	2	9139737
Pubmed	The immune receptor CD300e negatively regulates T cell activation by impairing the STAT1-dependent antigen presentation.	CD300E STAT1	5.90e-06	2	85	2	33020563
Pubmed	A novel CFHR1-CFHR5 hybrid leads to a familial dominant C3 glomerulopathy.	CFHR1 CFHR5	5.90e-06	2	85	2	28729035
Pubmed	A brain-to-spinal sensorimotor loop for repetitive self-grooming.	MRGPRX1 MRGPRX3 MRGPRX4	6.28e-06	15	85	3	34932943
Pubmed	DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon.	MRGPRX1 MRGPRX3 MRGPRX4	6.28e-06	15	85	3	37541195
Pubmed	Incoherent feed-forward regulatory loops control segregation of C-mechanoreceptors, nociceptors, and pruriceptors.	MRGPRX1 MRGPRX3 MRGPRX4	9.35e-06	17	85	3	25834056
Pubmed	p75 Is Required for the Establishment of Postnatal Sensory Neuron Diversity by Potentiating Ret Signaling.	MRGPRX1 MRGPRX3 MRGPRX4	1.12e-05	18	85	3	29045838
Pubmed	C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway.	MRGPRX1 MRGPRX3 MRGPRX4	1.33e-05	19	85	3	38915692
Pubmed	Tlx3 and Runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors, and pruriceptors.	MRGPRX1 MRGPRX3 MRGPRX4	1.33e-05	19	85	3	22787056
Pubmed	Uncoupling of molecular maturation from peripheral target innervation in nociceptors expressing a chimeric TrkA/TrkC receptor.	MRGPRX1 MRGPRX3 MRGPRX4	1.33e-05	19	85	3	24516396
Pubmed	Meis1 Regulates Nociceptor Development and Behavioral Response to Tactile Stimuli.	MRGPRX1 MRGPRX3 MRGPRX4	1.56e-05	20	85	3	35875660
Pubmed	Dihydrolipoamide dehydrogenase of Pseudomonas aeruginosa is a surface-exposed immune evasion protein that binds three members of the factor H family and plasminogen.	CFHR1 PLG	1.77e-05	3	85	2	23071278
Pubmed	An IFNγ/STAT1/JMJD3 Axis Induces ZEB1 Expression and Promotes Aggressiveness in Lung Adenocarcinoma.	KDM6B STAT1	1.77e-05	3	85	2	33771881
Pubmed	Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi.	MBTPS1 SREBF2	1.77e-05	3	85	2	10619424
Pubmed	Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies.	CFHR1 CFHR2	1.77e-05	3	85	2	31273197
Pubmed	Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity.	CFHR1 PLG	1.77e-05	3	85	2	19308255
Pubmed	A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease.	PRKDC STAT1	1.77e-05	3	85	2	23142821
Pubmed	STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infection.	CD1D STAT1	1.77e-05	3	85	2	19587017
Pubmed	Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization.	MBTPS1 SREBF2	1.77e-05	3	85	2	9990022
Pubmed	The opportunistic human pathogenic fungus Aspergillus fumigatus evades the host complement system.	CFHR1 PLG	1.77e-05	3	85	2	18039838
Pubmed	Hierarchical Specification of Pruriceptors by Runt-Domain Transcription Factor Runx1.	MRGPRX1 MRGPRX3 MRGPRX4	1.82e-05	21	85	3	28476948
Pubmed	Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation.	MRGPRX1 MRGPRX3 MRGPRX4	2.41e-05	23	85	3	20096094
Pubmed	A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons.	MRGPRX1 MRGPRX3 MRGPRX4	2.75e-05	24	85	3	17553423
Pubmed	Atypical haemolytic-uraemic syndrome due to heterozygous mutations of CFH/CFHR1-3 and complement factor H 479.	CFHR1 CFHR2	3.53e-05	4	85	2	24333077
Pubmed	Studies on the Detection, Expression, Glycosylation, Dimerization, and Ligand Binding Properties of Mouse Siglec-E.	SIGLEC12 SIGLEC7	3.53e-05	4	85	2	27920204
Pubmed	Early murine T-lymphocyte activation is accompanied by a switch from N-Glycolyl- to N-acetyl-neuraminic acid and generation of ligands for siglec-E.	SIGLEC12 SIGLEC7	3.53e-05	4	85	2	21835922
Pubmed	Human-specific elimination of epithelial Siglec-XII suppresses the risk of inflammation-driven colorectal cancers.	SIGLEC12 SIGLEC7	3.53e-05	4	85	2	38990656
Pubmed	Siglecs-7/9 function as inhibitory immune checkpoints in vivo and can be targeted to enhance therapeutic antitumor immunity.	SIGLEC12 SIGLEC7	3.53e-05	4	85	2	34155121
Pubmed	Polysialic acid and Siglec-E orchestrate negative feedback regulation of microglia activation.	SIGLEC12 SIGLEC7	3.53e-05	4	85	2	32725371
Pubmed	Leishmania donovani Utilize Sialic Acids for Binding and Phagocytosis in the Macrophages through Selective Utilization of Siglecs and Impair the Innate Immune Arm.	SIGLEC12 SIGLEC7	3.53e-05	4	85	2	27494323
Pubmed	Siglec-9 acts as an immune-checkpoint molecule on macrophages in glioblastoma, restricting T-cell priming and immunotherapy response.	SIGLEC12 SIGLEC7	3.53e-05	4	85	2	37460871
Pubmed	Group B Streptococcus engages an inhibitory Siglec through sialic acid mimicry to blunt innate immune and inflammatory responses in vivo.	SIGLEC12 SIGLEC7	3.53e-05	4	85	2	24391502
Pubmed	The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis.	SIGLEC12 SIGLEC7	3.53e-05	4	85	2	38454157
Pubmed	The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia.	KDM6B STAT1	3.53e-05	4	85	2	24097101
Pubmed	Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells.	SIGLEC12 SIGLEC7	3.53e-05	4	85	2	30130255
Pubmed	Dual actions of group B Streptococcus capsular sialic acid provide resistance to platelet-mediated antimicrobial killing.	SIGLEC12 SIGLEC7	3.53e-05	4	85	2	30910970
Pubmed	O-Acetylation of Capsular Polysialic Acid Enables Escherichia coli K1 Escaping from Siglec-Mediated Innate Immunity and Lysosomal Degradation of E. coli-Containing Vacuoles in Macrophage-Like Cells.	SIGLEC12 SIGLEC7	3.53e-05	4	85	2	34878295
Cytoband	11p15.1	MRGPRX1 MRGPRX3 MRGPRX4	1.94e-04	60	85	3	11p15.1
Cytoband	7q31.3	FSCN3 LRRC4	3.50e-04	15	85	2	7q31.3
Cytoband	Ensembl 112 genes in cytogenetic band chr1q31	CFHR1 CFHR2 CFHR5	3.76e-04	75	85	3	chr1q31
Cytoband	1q31.3	CFHR2 CFHR5	4.00e-04	16	85	2	1q31.3
Cytoband	11q23.2	NXPE4 CLDN25	5.08e-04	18	85	2	11q23.2
Cytoband	2p22.3	TTC27 BIRC6	5.68e-04	19	85	2	2p22.3
Cytoband	14q32.12	TC2N PRIMA1	1.33e-03	29	85	2	14q32.12
Cytoband	17p13.1	CTC1 KDM6B SPDYE4	1.40e-03	118	85	3	17p13.1
Cytoband	8p21.3	FHIP2B NPM2	2.28e-03	38	85	2	8p21.3
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CFHR1 CFHR2 CFHR5 CSMD3	3.32e-05	57	58	4	1179
GeneFamily	Complement system\|Sushi domain containing	CFHR1 CFHR2 CFHR5	2.07e-04	36	58	3	492
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	HERC2 UTRN	1.50e-03	18	58	2	91
GeneFamily	Adenosine receptors\|V-set domain containing	SIGLEC12 SIGLEC7 CD300E GPA33	1.85e-03	163	58	4	590
GeneFamily	G protein-coupled receptors, Class A orphans	MRGPRX1 MRGPRX3 MRGPRX4	2.01e-03	78	58	3	262
GeneFamily	CD molecules\|C2-set domain containing\|Sialic acid binding Ig like lectins	SIGLEC12 SIGLEC7	3.62e-03	28	58	2	745
GeneFamily	Solute carriers	SLC7A8 SLC17A9 SLC9B2 SLC4A10 SLC5A9	8.61e-03	395	58	5	752
ToppCell	10x5'-GI_small-bowel-Lymphocytic_Invariant-Inducer-like-MAIT\|GI_small-bowel / Manually curated celltypes from each tissue	CFHR1 CFHR2 PDSS2 TRPV2 SLC4A10	8.44e-06	146	84	5	1cb2e157222631e8915d89b255a843d16d7d99cc
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	SMG1 TRABD2A TC2N ZNF831 UTRN	1.40e-05	162	84	5	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	TCGA-Liver\|World / Sample_Type by Project: Shred V9	CFHR1 CFHR2 CFHR5 PLG ABCG5	1.97e-05	174	84	5	452932f08cf53e5949672a025d78cecb874aa4b0
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CFHR1 CFHR2 FECH CFHR5 PLG	2.78e-05	187	84	5	edb0ab0154542b1c0b3a2c216c4a60f0f06290b3
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic-erythrocytic\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CFHR1 CFHR2 FECH CFHR5 PLG	2.93e-05	189	84	5	7899af78b273d9c7f029d52f7e0cf6df4da41f5e
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic-erythrocytic-erythrocyte\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CFHR1 CFHR2 FECH CFHR5 PLG	3.00e-05	190	84	5	a34293601aefe5fb5c400c14091294b9ddaa195b
ToppCell	COVID-19_Moderate-CD4+_T_activated\|World / disease group, cell group and cell class	BCL2L14 TRABD2A LSR TC2N STAT1	3.23e-05	193	84	5	c2a2a2c14a7085690262db5c2a70e38db67dee18
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TRABD2A LSR NXPE4 MUC2 GPA33	3.48e-05	196	84	5	79bc7ab96b52b2a542348a13ddd0a4f095698c5e
ToppCell	COVID-19_Mild\|World / Disease group, lineage and cell class	SMG1 KDM6B UTRN CD300E STAT1	3.57e-05	197	84	5	5c33454b10023decd2f5ccda9229b6512659711e
ToppCell	COVID-19_Mild\|World / Disease condition and Cell class	SMG1 KDM6B UTRN CD300E STAT1	3.65e-05	198	84	5	61ceb2245b6cb58e308b999a61d218c89dbc615e
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	SMG1 KDM6B UTRN CD300E STAT1	3.65e-05	198	84	5	44417089b62056269cac38d3134ff209c05b7007
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SMG1 KDM6B UTRN CD300E STAT1	3.65e-05	198	84	5	28ef3fc4c17dcb765537b75917f7db78baa522db
ToppCell	COVID-19-COVID-19_Mild\|COVID-19 / Disease, condition lineage and cell class	SMG1 KDM6B UTRN CD300E STAT1	3.83e-05	200	84	5	62c25042086f1afd1102e0720e933c2e476468fd
Disease	C3 glomerulopathy	CFHR1 CFHR2 CFHR5	1.72e-06	9	82	3	C4087273
Disease	CFHR5 DEFICIENCY	CFHR1 CFHR5	7.63e-06	2	82	2	C3553720
Disease	Complement deficiency disease	CFHR1 CFHR2 CFHR5	1.06e-04	33	82	3	C0272242
Disease	complement factor H-related protein 5 measurement	CFHR1 CFHR2 CFHR5	2.20e-04	42	82	3	EFO_0008098
Disease	sialic acid-binding Ig-like lectin 9 measurement	SIGLEC12 SIGLEC7	2.71e-04	9	82	2	EFO_0008286
Disease	complement factor H-related protein 4 measurement	CFHR1 CFHR2 CFHR5	3.48e-04	49	82	3	EFO_0600091
Disease	hemopexin measurement	CFHR1 CFHR5	4.13e-04	11	82	2	EFO_0008149
Disease	complement factor H-related protein 1 measurement	CFHR1 CFHR2 CFHR5	5.16e-04	56	82	3	EFO_0600054
Disease	Hepatic Encephalopathy	GABRG2 PRKDC	5.83e-04	13	82	2	C0019151
Disease	Hepatic Coma	GABRG2 PRKDC	5.83e-04	13	82	2	C0019147
Disease	Fulminant Hepatic Failure with Cerebral Edema	GABRG2 PRKDC	5.83e-04	13	82	2	C0751197
Disease	Hepatic Stupor	GABRG2 PRKDC	5.83e-04	13	82	2	C0751198
Disease	myeloid cell surface antigen CD33 measurement	SIGLEC12 SIGLEC7	7.82e-04	15	82	2	EFO_0008238
Disease	idiopathic scoliosis (implicated_via_orthology)	MBTPS1 SSPOP	8.93e-04	16	82	2	DOID:0060250 (implicated_via_orthology)
Disease	skin pigmentation	CFHR2 CFHR5 HERC2	9.50e-04	69	82	3	EFO_0003784
Disease	Hypercholesterolemia, Familial	SREBF2 ABCG5	1.13e-03	18	82	2	C0020445
Disease	sensorineural hearing loss (implicated_via_orthology)	SLC7A8 DNAH17	1.27e-03	19	82	2	DOID:10003 (implicated_via_orthology)
Disease	skin sensitivity to sun	RXFP3 HERC2	1.27e-03	19	82	2	EFO_0004795
Disease	free cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	TTC27 NHLRC2 PLG BIRC6 ABCG5	1.58e-03	303	82	5	EFO_0004612, EFO_0020945
Disease	age-related macular degeneration	CFHR1 CFHR5 HERC2	1.98e-03	89	82	3	EFO_0001365
Disease	Agents acting on the renin-angiotensin system use measurement	SLC9B2 PKHD1 NHLRC2 KDM6B ZNF831	2.45e-03	335	82	5	EFO_0009931
Disease	cerebrospinal fluid biomarker measurement	SIGLEC7 CFHR5 NPM2	2.45e-03	96	82	3	EFO_0006794

Protein segments in the cluster

Peptide	Gene	Start	Entry
RWNSTSWSTGCKLPA	CASTOR3	11	Q8NAP1
VLWVWCYPSTTATLR	DENND10P1	26	Q6NSW5
TVLAWYPNTLLRTWC	BIRC6	2706	Q9NR09
SIECLPNGTWSWRNE	CSMD3	2736	Q7Z407
LPSCQLNRRLAWSWL	CTC1	581	Q2NKJ3
LNRRLAWSWLCLLPS	CTC1	586	Q2NKJ3
SCWDPTQCTRTWLLS	C19orf48	31	Q6RUI8
LWSSCVVLPLLALTW	ADGRB1	1136	O14514
IQTVWVLDSWSRDPS	CD300E	106	Q496F6
WELCPVTIISWLNLF	CCNE2	236	O96020
WVCSCVTTILPQWKT	CLDN25	21	C9JDP6
SWTEVSWPCRNSQSS	BCL2L14	66	Q9BZR8
RRLWWSPSLDTISSV	PDSS2	21	Q86YH6
SPLSTEQWLWCLFVG	ATP2B3	1031	Q16720
PRWAIIGWLLTTCTS	INTS3	371	Q68E01
NLTPTNCSWWPISAL	GDAP1L1	6	Q96MZ0
NCSWWPISALESDAA	GDAP1L1	11	Q96MZ0
DFTSIPAACWWVIIS	KCNG3	356	Q8TAE7
LLTWVNCSSVRWATR	SLC7A8	171	Q9UHI5
DFLVWRWIQPSASCD	LEMD3	741	Q9Y2U8
CPTDVRQWATSSLSW	ORC4	421	O43929
AWNTVREILTSPSCW	NSUN3	36	Q9H649
QNFWATWTSVTRPIC	KIAA0100	1286	Q14667
WTVPFLSWLAIVALC	MCTP1	911	Q6DN14
PCNETRWSQKWQSSR	MBTPS1	146	Q14703
WPVLWTLCAVRVTVD	GPA33	6	Q99795
WSSCSEWSIGLRVPF	HERC2	776	O95714
NWDLTGTRQIWPCES	KDM6B	1256	O15054
QIPEAWSCAWSLNTR	DCAF4L1	181	Q3SXM0
QECSSRVASWGWPLT	FHIP2B	571	Q86V87
STTPKLCCLWSDWIN	MUC2	1296	Q02817
FWTRITCAEEGWSPT	CFHR2	66	P36980
LAWWLREYIPTNSTC	LRRC4	311	Q9HBW1
PWLFSLAWCSRINSV	GDPD4	431	Q6W3E5
TDNLWDTLPCSWQEA	METTL25B	41	Q96FB5
ISTERCLSILWPIWY	MRGPRX3	116	Q96LB0
ASLWQELEVSCWPTL	NHLRC2	151	Q8NBF2
LCWSWIPITSLTKNS	LRRIQ1	936	Q96JM4
WENITLWCRSPSRIS	IGSF1	51	Q8N6C5
PTCVLVRVRWWGETS	C2CD3	56	Q4AC94
ALTCTQIWWTTEVGL	DNAH17	1696	Q9UFH2
WTRETVQWLLNGTCP	CD1D	171	P15813
CPEWNSWSQLIISTD	CLCN5	186	P51795
WFILQHCPTWVSLRS	FSCN3	256	Q9NQT6
IPCTLIVVLSWVSFW	GABRG2	281	P18507
SVSHRVRPWWDITSC	ABCG5	46	Q9H222
FWTRITCTEEGWSPT	CFHR5	66	Q9BXR6
WIVSSCLCRAWTAPS	CNTNAP2	16	Q9UHC6
DPLASSSWRVCQPWR	FECH	21	P22830
FWTRITCTEEGWSPT	CFHR1	66	Q03591
VLWVWCYPSTTATLR	DENND10	26	Q8TCE6
RLTWSWCSDHRTPTC	SCNN1D	26	P51172
TVLWGCELSQERRTW	NPM2	16	Q86SE8
WLLLSTWCTAPARAI	LSR	76	Q86X29
FLCWLPNQALTTWSI	RXFP3	336	Q9NSD7
LCVLNAGWSRVRTWT	UTRN	1626	P46939
PCARWAQLSEVLSWQ	STAT1	491	P42224
WSSLRNTWSKCEILE	TDRD6	2036	O60522
DCVLAPWSVWSSCSR	SSPOP	2501	A2VEC9
TIDNWLREVNLWCPT	SMARCAD1	556	Q9H4L7
WITVLQCRDLSWPSS	TC2N	241	Q8N9U0
WRNTWNPVSCSLATV	NXPE4	321	Q6UWF7
ERGTCLWRPWLSSTN	RIPPLY1	51	Q0D2K3
TSCPTEESWWSGLVI	PRIMA1	81	Q86XR5
VIWRQLISSCPWLSE	SMG1	1706	Q96Q15
LLWAVVWSITGSECL	SLC9B2	96	Q86UD5
CAVDSNPPARLSWTW	SIGLEC7	276	Q9Y286
ESAWNIRKLSPTLCW	SHQ1	296	Q6PI26
IRKLSPTLCWFETWT	SHQ1	301	Q6PI26
PEEQLTRLTWWTRNC	SLC5A9	556	Q2M3M2
TRLTWWTRNCPLSEL	SLC5A9	561	Q2M3M2
TQWSRPECQAWTGTL	SLC17A9	16	Q9BYT1
WSLTRTSPESWQFDC	PKHD1	646	P08F94
VSTERCLSVLWPIWY	MRGPRX1	116	Q96LB2
ISTERCLSVLWPIWY	MRGPRX4	116	Q96LA9
SWCETSDFIPVAWLI	MRGPRX4	171	Q96LA9
RAPWCHTTNSQVRWE	PLG	331	P00747
CAVDSNPPARLSWTW	SIGLEC12	401	Q96PQ1
ISSQRSWPLWTTIFI	TMPRSS11B	6	Q86T26
AGDICTTSWQLSPVW	PYROXD1	356	Q8WU10
LLCSMRWRTWVSPEE	SPDYE4	201	A6NLX3
RVWQISDQTCAISWP	WDHD1	161	O75717
WWTVIAAIIPALLCT	SLC4A10	811	Q6U841
SALGPDIICRWWTSA	SREBF2	866	Q12772
WASWEQTLPTLCEDP	TRPV2	711	Q9Y5S1
SACLSLWTPVFWVLV	TRABD2A	481	Q86V40
VSCLFLCSLVWLPSW	SUCO	11	Q9UBS9
PAVWVKISSSWVCLL	SERINC3	441	Q13530
VLQRPQTWADCVTWA	UBA1	696	P22314
EISSVPCWQFISWIS	PRKDC	3486	P78527
QETCLWAQTVLRWPS	ZNF831	796	Q5JPB2
TAIQSLPWWTLRCVN	TTC27	176	Q6P3X3
WPCSVSWQQQAASRL	VPS13D	2771	Q5THJ4