Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR51L1 OR52B4 OR51B5 OR6V1 GPR26 OR1J1 OR13C3 OR4E2 ADGRB1 OXGR1 ADGRB3 OR8S1 CCRL2 OR5K3 OR8H1 ADGRA1 GPRC6A OR2J2 ADGRV1 OR5M8 OR1J2 CNR2 GPR179 OR8G2P	2.64e-14	884	79	24	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR51L1 OR52B4 OR51B5 OR6V1 GPR26 OR1J1 OR13C3 GLRA2 OR4E2 ADGRB1 OXGR1 ADGRB3 OR8S1 CCRL2 OR5K3 OR8H1 ADGRA1 GPRC6A OR2J2 ADGRV1 OR5M8 OR1J2 CNR2 GPR179 OR8G2P	3.41e-11	1353	79	25	GO:0004888
GeneOntologyMolecularFunction	olfactory receptor activity	OR51L1 OR52B4 OR51B5 OR6V1 OR1J1 OR13C3 OR4E2 OR8S1 OR5K3 OR8H1 OR2J2 OR5M8 OR1J2 OR8G2P	1.34e-09	431	79	14	GO:0004984
GeneOntologyMolecularFunction	anandamide 8,9 epoxidase activity	CYP2D7 CYP2D6	9.23e-05	4	79	2	GO:0062187
GeneOntologyMolecularFunction	anandamide 11,12 epoxidase activity	CYP2D7 CYP2D6	9.23e-05	4	79	2	GO:0062188
GeneOntologyMolecularFunction	steroid 21-monooxygenase activity	CYP2D7 CYP2D6	9.23e-05	4	79	2	GO:0004509
GeneOntologyMolecularFunction	progesterone 21-hydroxylase activity	CYP2D7 CYP2D6	9.23e-05	4	79	2	GO:0106309
GeneOntologyMolecularFunction	odorant binding	OR4E2 OR5K3 OR8H1 OR5M8 OR8G2P	1.49e-04	127	79	5	GO:0005549
GeneOntologyMolecularFunction	anandamide 14,15 epoxidase activity	CYP2D7 CYP2D6	2.29e-04	6	79	2	GO:0062189
GeneOntologyMolecularFunction	anandamide epoxidase activity	CYP2D7 CYP2D6	2.29e-04	6	79	2	GO:0062186
GeneOntologyMolecularFunction	ubiquinone binding	COQ10A COQ10B	3.20e-04	7	79	2	GO:0048039
GeneOntologyMolecularFunction	steroid hydroxylase activity	CYP1A2 CYP2D7 CYP2D6	3.26e-04	34	79	3	GO:0008395
GeneOntologyMolecularFunction	aromatase activity	CYP1A2 CYP2D7 CYP2D6	3.56e-04	35	79	3	GO:0070330
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP1A2 CYP2D7 CYP2D6	9.63e-04	49	79	3	GO:0016712
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	ANO9 KCNH7 GLRA2 KCNJ11 ANO1	1.01e-03	193	79	5	GO:0015276
GeneOntologyMolecularFunction	ligand-gated monoatomic anion channel activity	ANO9 GLRA2 ANO1	1.02e-03	50	79	3	GO:0099095
GeneOntologyMolecularFunction	intramembrane lipid transporter activity	ANO9 ANO1 ATP9A	1.08e-03	51	79	3	GO:0140303
GeneOntologyMolecularFunction	ligand-gated channel activity	ANO9 KCNH7 GLRA2 KCNJ11 ANO1	1.11e-03	197	79	5	GO:0022834
GeneOntologyMolecularFunction	chloride transmembrane transporter activity	ANO9 SLC18A1 GLRA2 ANO1	1.53e-03	125	79	4	GO:0015108
GeneOntologyMolecularFunction	quinone binding	COQ10A COQ10B	2.02e-03	17	79	2	GO:0048038
GeneOntologyMolecularFunction	intracellularly calcium-gated channel activity	ANO9 ANO1	2.80e-03	20	79	2	GO:0141147
GeneOntologyMolecularFunction	intracellularly calcium-gated chloride channel activity	ANO9 ANO1	2.80e-03	20	79	2	GO:0005229
GeneOntologyMolecularFunction	monoatomic anion transmembrane transporter activity	ANO9 SLC18A1 GLRA2 ANO1	3.04e-03	151	79	4	GO:0008509
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR51L1 GHRH OR52B4 OR51B5 OR6V1 GPR26 OR1J1 OR13C3 GLRA2 OR4E2 ADGRB1 OXGR1 ADGRB3 ANO1 OR8S1 CCRL2 OR5K3 OR8H1 ADGRA1 GPRC6A OR2J2 ADGRV1 OR5M8 BAIAP3 OR1J2 CNR2 GPR179 OR8G2P	1.27e-13	1395	80	28	GO:0007186
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR51L1 OR52B4 OR51B5 OR6V1 OR1J1 OR13C3 PJVK OR4E2 ANO1 OR8S1 OR5K3 OR8H1 OR2J2 ADGRV1 OR5M8 OR1J2 OR8G2P	7.06e-11	582	80	17	GO:0050906
GeneOntologyBiologicalProcess	detection of stimulus	OR51L1 OR52B4 OR51B5 OR6V1 NOD1 OR1J1 OR13C3 PJVK OR4E2 ANO1 OR8S1 OR5K3 OR8H1 OR2J2 ADGRV1 OR5M8 OR1J2 OR8G2P	2.35e-10	722	80	18	GO:0051606
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR51L1 OR52B4 OR51B5 OR6V1 OR1J1 OR13C3 OR4E2 OR8S1 OR5K3 OR8H1 OR2J2 OR5M8 OR1J2 OR8G2P	1.09e-09	432	80	14	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR51L1 OR52B4 OR51B5 OR6V1 OR1J1 OR13C3 OR4E2 OR8S1 OR5K3 OR8H1 OR2J2 OR5M8 OR1J2 OR8G2P	2.80e-09	465	80	14	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR51L1 OR52B4 OR51B5 OR6V1 OR1J1 OR13C3 OR4E2 OR8S1 OR5K3 OR8H1 OR2J2 OR5M8 OR1J2 OR8G2P	4.79e-09	485	80	14	GO:0050907
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR51L1 OR52B4 OR51B5 OR6V1 OR1J1 OR13C3 OR4E2 OR8S1 OR5K3 OR8H1 OR2J2 OR5M8 OR1J2 OR8G2P	1.27e-08	524	80	14	GO:0009593
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR51L1 OR52B4 OR51B5 OR6V1 OR1J1 OR13C3 OR4E2 OR8S1 OR5K3 OR8H1 OR2J2 OR5M8 OR1J2 OR8G2P	2.18e-08	547	80	14	GO:0007606
GeneOntologyBiologicalProcess	sensory perception	OR51L1 OR52B4 OR51B5 OR6V1 OR1J1 OR13C3 PJVK OR4E2 ANO1 OR8S1 OR5K3 OR8H1 OR2J2 ADGRV1 OR5M8 OR1J2 GPR179 OR8G2P	1.10e-07	1072	80	18	GO:0007600
GeneOntologyBiologicalProcess	oxidative demethylation	CYP1A2 CYP2D7 CYP2D6	1.21e-05	12	80	3	GO:0070989
GeneOntologyBiologicalProcess	serotonin biosynthetic process from tryptophan	CYP2D7 CYP2D6	4.45e-05	3	80	2	GO:0006587
GeneOntologyBiologicalProcess	regulation of G1 to G0 transition	MYBBP1A RRP8	8.87e-05	4	80	2	GO:1903450
GeneOntologyBiologicalProcess	demethylation	CYP1A2 CYP2D7 CYP2D6	1.07e-04	24	80	3	GO:0070988
GeneOntologyBiologicalProcess	monoterpenoid metabolic process	CYP1A2 CYP2D6	2.21e-04	6	80	2	GO:0016098
GeneOntologyBiologicalProcess	xenobiotic catabolic process	CYP1A2 CYP2D7 CYP2D6	3.97e-04	37	80	3	GO:0042178
GeneOntologyBiologicalProcess	serotonin biosynthetic process	CYP2D7 CYP2D6	4.10e-04	8	80	2	GO:0042427
GeneOntologyCellularComponent	periciliary membrane compartment	KIFAP3 ADGRV1	2.15e-04	6	80	2	GO:1990075
GeneOntologyCellularComponent	B-WICH complex	MYBBP1A ERCC6	3.99e-04	8	80	2	GO:0110016
Domain	GPCR_Rhodpsn_7TM	OR51L1 OR52B4 OR51B5 OR6V1 GPR26 OR1J1 OR13C3 OR4E2 OXGR1 OR8S1 CCRL2 OR5K3 OR8H1 OR2J2 OR5M8 OR1J2 CNR2 OR8G2P	2.19e-10	670	78	18	IPR017452
Domain	7tm_1	OR51L1 OR52B4 OR51B5 OR6V1 GPR26 OR1J1 OR13C3 OR4E2 OXGR1 OR8S1 CCRL2 OR5K3 OR8H1 OR2J2 OR5M8 OR1J2 CNR2 OR8G2P	2.59e-10	677	78	18	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR51L1 OR52B4 OR51B5 OR6V1 GPR26 OR1J1 OR13C3 OR4E2 OXGR1 OR8S1 CCRL2 OR5K3 OR8H1 OR2J2 OR5M8 OR1J2 CNR2 OR8G2P	3.13e-10	685	78	18	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR51L1 OR52B4 OR51B5 OR6V1 GPR26 OR1J1 OR13C3 OR4E2 OXGR1 OR8S1 CCRL2 OR5K3 OR8H1 OR2J2 OR5M8 OR1J2 CNR2 OR8G2P	3.60e-10	691	78	18	PS50262
Domain	GPCR_Rhodpsn	OR51L1 OR52B4 OR51B5 OR6V1 GPR26 OR1J1 OR13C3 OR4E2 OXGR1 OR8S1 CCRL2 OR5K3 OR8H1 OR2J2 OR5M8 OR1J2 CNR2 OR8G2P	3.69e-10	692	78	18	IPR000276
Domain	Olfact_rcpt	OR51L1 OR52B4 OR51B5 OR6V1 OR1J1 OR13C3 OR4E2 OR8S1 OR5K3 OR8H1 OR2J2 OR5M8 OR1J2 OR8G2P	7.99e-10	393	78	14	IPR000725
Domain	COQ10_START	COQ10A COQ10B	1.72e-05	2	78	2	IPR005031
Domain	Polyketide_cyc	COQ10A COQ10B	1.72e-05	2	78	2	PF03364
Domain	GPCR_2_brain_angio_inhib	ADGRB1 ADGRB3	5.15e-05	3	78	2	IPR008077
Domain	G_PROTEIN_RECEP_F2_2	ADGRB1 ADGRB3 ADGRA1 ADGRV1	5.60e-05	50	78	4	PS00650
Domain	7tm_2	ADGRB1 ADGRB3 ADGRA1 ADGRV1	5.60e-05	50	78	4	PF00002
Domain	GPCR_2_secretin-like	ADGRB1 ADGRB3 ADGRA1 ADGRV1	1.15e-04	60	78	4	IPR000832
Domain	GPCR_2-like	ADGRB1 ADGRB3 ADGRA1 ADGRV1	1.15e-04	60	78	4	IPR017981
Domain	G_PROTEIN_RECEP_F2_4	ADGRB1 ADGRB3 ADGRA1 ADGRV1	1.23e-04	61	78	4	PS50261
Domain	Mob1_phocein	MOB1B MOB1A	3.57e-04	7	78	2	PF03637
Domain	MOB_kinase_act_fam	MOB1B MOB1A	3.57e-04	7	78	2	IPR005301
Domain	-	MOB1B MOB1A	3.57e-04	7	78	2	1.20.140.30
Domain	Mob1_phocein	MOB1B MOB1A	3.57e-04	7	78	2	SM01388
Domain	GPS	ADGRB1 ADGRB3 ADGRV1	3.82e-04	34	78	3	SM00303
Domain	GPS	ADGRB1 ADGRB3 ADGRV1	4.17e-04	35	78	3	PF01825
Domain	GPS	ADGRB1 ADGRB3 ADGRV1	4.53e-04	36	78	3	PS50221
Domain	GPS	ADGRB1 ADGRB3 ADGRV1	4.92e-04	37	78	3	IPR000203
Domain	G_PROTEIN_RECEP_F2_1	ADGRB1 ADGRB3 ADGRV1	6.19e-04	40	78	3	PS00649
Domain	GPCR_2_extracellular_dom	ADGRB1 ADGRB3 ADGRV1	6.19e-04	40	78	3	IPR001879
Domain	G_PROTEIN_RECEP_F2_3	ADGRB1 ADGRB3 ADGRV1	6.19e-04	40	78	3	PS50227
Domain	Anoctamin	ANO9 ANO1	7.58e-04	10	78	2	PF04547
Domain	Anoctamin	ANO9 ANO1	7.58e-04	10	78	2	IPR007632
Domain	GAIN_dom_N	ADGRB1 ADGRB3	9.24e-04	11	78	2	IPR032471
Domain	GAIN	ADGRB1 ADGRB3	9.24e-04	11	78	2	PF16489
Domain	GPCR_3	GPRC6A GPR179	3.43e-03	21	78	2	IPR000337
Domain	7tm_3	GPRC6A GPR179	3.77e-03	22	78	2	PF00003
Domain	G_PROTEIN_RECEP_F3_2	GPRC6A GPR179	3.77e-03	22	78	2	PS00980
Domain	G_PROTEIN_RECEP_F3_3	GPRC6A GPR179	3.77e-03	22	78	2	PS00981
Domain	G_PROTEIN_RECEP_F3_1	GPRC6A GPR179	3.77e-03	22	78	2	PS00979
Domain	G_PROTEIN_RECEP_F3_4	GPRC6A GPR179	3.77e-03	22	78	2	PS50259
Domain	GPCR_3_C	GPRC6A GPR179	3.77e-03	22	78	2	IPR017978
Domain	NACHT	NOD1 NLRP13	4.12e-03	23	78	2	PS50837
Domain	NACHT_NTPase	NOD1 NLRP13	4.12e-03	23	78	2	IPR007111
Domain	-	COQ10A COQ10B	4.12e-03	23	78	2	3.30.530.20
Domain	START-like_dom	COQ10A COQ10B	4.12e-03	23	78	2	IPR023393
Domain	HormR	ADGRB1 ADGRB3	4.85e-03	25	78	2	SM00008
Domain	HRM	ADGRB1 ADGRB3	6.07e-03	28	78	2	PF02793
Domain	SNF2_N	ERCC6 RAD54B	7.87e-03	32	78	2	IPR000330
Domain	SNF2_N	ERCC6 RAD54B	7.87e-03	32	78	2	PF00176
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR51L1 OR52B4 OR51B5 OR6V1 OR1J1 OR13C3 OR4E2 OR8S1 OR8H1 OR2J2 OR5M8 OR1J2 OR8G2P	7.14e-08	389	72	13	M14091
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR51L1 OR51B5 OR6V1 OR1J1 OR13C3 OR4E2 OR8S1 OR5K3 OR8H1 OR2J2 OR5M8 OR1J2	1.18e-06	417	72	12	M4072
Pathway	REACTOME_SENSORY_PERCEPTION	OR51L1 OR51B5 OR6V1 OR1J1 OR13C3 PJVK OR4E2 OR8S1 OR5K3 OR8H1 OR2J2 OR5M8 OR1J2	1.72e-05	636	72	13	M41834
Pathway	REACTOME_BIOSYNTHESIS_OF_MARESINS	CYP1A2 CYP2D7 CYP2D6	2.72e-05	12	72	3	MM15616
Pathway	REACTOME_BIOSYNTHESIS_OF_SPECIALIZED_PRORESOLVING_MEDIATORS_SPMS	CYP1A2 CYP2D7 CYP2D6	1.83e-04	22	72	3	MM15614
Pathway	REACTOME_XENOBIOTICS	CYP1A2 CYP2D7 CYP2D6	2.71e-04	25	72	3	MM14846
Pathway	REACTOME_BIOSYNTHESIS_OF_MARESIN_LIKE_SPMS	CYP1A2 CYP2D6	3.81e-04	6	72	2	M27909
Pathway	REACTOME_BIOSYNTHESIS_OF_MARESINS	CYP1A2 CYP2D6	7.06e-04	8	72	2	M27891
Pubmed	The human olfactory receptor gene family.	OR51L1 OR52B4 OR51B5 OR6V1 OR1J1 OR13C3 OR4E2 OR8H1 OR2J2 OR5M8 OR1J2 OR8G2P	4.10e-09	541	80	12	14983052
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR52B4 OR1J1 OR13C3 OR4E2 OR8S1 OR5K3 OR8H1 OR2J2 OR5M8 OR8G2P	6.28e-09	340	80	10	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR52B4 OR1J1 OR13C3 OR4E2 OR8S1 OR5K3 OR8H1 OR2J2 OR5M8 OR8G2P	6.28e-09	340	80	10	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR52B4 OR1J1 OR13C3 OR4E2 OR8S1 OR5K3 OR8H1 OR2J2 OR5M8 OR8G2P	6.82e-09	343	80	10	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR52B4 OR1J1 OR13C3 OR4E2 OR8S1 OR5K3 OR8H1 OR2J2 OR5M8 OR8G2P	7.41e-09	346	80	10	14611657
Pubmed	Effects of infection of MRSA on the expression and activity of renal cytochrome P450s in mice.	CYP1A2 CYP2D7 CYP2D6	4.07e-07	7	80	3	30944282
Pubmed	The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.	ADGRB1 ADGRB3 ADGRA1 ADGRV1	5.90e-07	29	80	4	15203201
Pubmed	International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.	ADGRB1 ADGRB3 ADGRA1 ADGRV1	1.01e-06	33	80	4	25713288
Pubmed	Depletion of MOB1A/B causes intestinal epithelial degeneration by suppressing Wnt activity and activating BMP/TGF-β signaling.	MOB1B MOB1A	5.23e-06	2	80	2	30349003
Pubmed	Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice.	MOB1B MOB1A	5.23e-06	2	80	2	23143302
Pubmed	Characterization of Cyp2d22, a novel cytochrome P450 expressed in mouse mammary cells.	CYP2D7 CYP2D6	5.23e-06	2	80	2	11032406
Pubmed	Clinical Presentation, Genetic Etiology, and Coenzyme Q10 Levels in 55 Children with Combined Enzyme Deficiencies of the Mitochondrial Respiratory Chain.	COQ10A COQ10B	5.23e-06	2	80	2	32827528
Pubmed	Association study between functional polymorphisms in the cytochrome P450 1A2 and 2D6 genes and polydipsia in schizophrenia.	CYP1A2 CYP2D6	5.23e-06	2	80	2	16775389
Pubmed	Molecular evolution of the CYP2D subfamily in primates: purifying selection on substrate recognition sites without the frequent or long-tract gene conversion.	CYP2D7 CYP2D6	5.23e-06	2	80	2	25808902
Pubmed	Effects of exogenous p53 transfection on the gene expression in the human brain glioma cell line U251.	MYBBP1A METTL9	5.23e-06	2	80	2	16413759
Pubmed	Polymorphisms in CYP2D6 duplication-negative individuals with the ultrarapid metabolizer phenotype: a role for the CYP2D6*35 allele in ultrarapid metabolism?	CYP2D7 CYP2D6	5.23e-06	2	80	2	11207030
Pubmed	Cigarette smoking and heavy coffee consumption affecting response to olanzapine: The role of genetic polymorphism.	CYP1A2 CYP2D6	5.23e-06	2	80	2	30513034
Pubmed	Assessment of Serum CoQ10 Levels and other Antioxidant Markers in Breast Cancer.	COQ10A COQ10B	5.23e-06	2	80	2	32102525
Pubmed	The major fluvoxamine metabolite in urine is formed by CYP2D6.	CYP1A2 CYP2D6	5.23e-06	2	80	2	11791895
Pubmed	Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1.	ADGRB1 BAIAP3	5.23e-06	2	80	2	9790924
Pubmed	CTRP-3 Regulates NOD1-mediated Inflammation and NOD1 Expression in Adipocytes and Adipose Tissue.	NOD1 C1QTNF3	5.23e-06	2	80	2	34165676
Pubmed	Characterization of the common genetic defect in humans deficient in debrisoquine metabolism.	CYP2D7 CYP2D6	5.23e-06	2	80	2	3123997
Pubmed	The expression of CYP2D22, an ortholog of human CYP2D6, in mouse striatum and its modulation in 1-methyl 4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease phenotype and nicotine-mediated neuroprotection.	CYP2D7 CYP2D6	5.23e-06	2	80	2	19594327
Pubmed	Impact of CYP1A2 and CYP2D6 polymorphisms on drug metabolism and on insulin and lipid elevations and insulin resistance in clozapine-treated patients.	CYP1A2 CYP2D6	5.23e-06	2	80	2	17503978
Pubmed	Coding-noncoding gene expression in intrahepatic cholangiocarcinoma.	CYP2D7 CYP2D6	5.23e-06	2	80	2	26297049
Pubmed	Human Mob1 proteins are required for cytokinesis by controlling microtubule stability.	MOB1B MOB1A	5.23e-06	2	80	2	22454515
Pubmed	A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine.	CYP2D7 CYP2D6	5.23e-06	2	80	2	15051713
Pubmed	Subgrouping of patients with oral lichen planus according to cytochrome P450 enzyme phenotype and genotype.	CYP1A2 CYP2D6	5.23e-06	2	80	2	25240994
Pubmed	Levels of Coenzyme Q10 and Several COQ Proteins in Human Astrocytoma Tissues Are Inversely Correlated with Malignancy.	COQ10A COQ10B	5.23e-06	2	80	2	35204836
Pubmed	Effects of cigarette smoking and cytochrome P450 2D6 genotype on fluvoxamine concentration in plasma of Japanese patients.	CYP1A2 CYP2D6	5.23e-06	2	80	2	20118554
Pubmed	EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1.	MOB1B MOB1A	1.57e-05	3	80	2	34725466
Pubmed	The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.	CYP2D7 CYP2D6	1.57e-05	3	80	2	2574001
Pubmed	The relationship between the response of clinical symptoms and plasma olanzapine concentration, based on pharmacogenetics: Juntendo University Schizophrenia Projects (JUSP).	CYP1A2 CYP2D6	1.57e-05	3	80	2	18223460
Pubmed	The human tumour suppressor LATS1 is activated by human MOB1 at the membrane.	MOB1B MOB1A	1.57e-05	3	80	2	16674920
Pubmed	Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1).	ADGRB1 ADGRB3	1.57e-05	3	80	2	9533023
Pubmed	Characterization of human cytochrome P450 enzymes catalyzing domperidone N-dealkylation and hydroxylation in vitro.	CYP1A2 CYP2D6	1.57e-05	3	80	2	15327587
Pubmed	Expression of brain-specific angiogenesis inhibitor 3 (BAI3) in normal brain and implications for BAI3 in ischemia-induced brain angiogenesis and malignant glioma.	ADGRB1 ADGRB3	1.57e-05	3	80	2	15225653
Pubmed	Neither cytochrome P450 family genes nor neuroendocrine factors could independently predict the SSRIs treatment in the Chinese Han population.	CYP1A2 CYP2D6	1.57e-05	3	80	2	24488700
Pubmed	Identification of the primary gene defect at the cytochrome P450 CYP2D locus.	CYP2D7 CYP2D6	1.57e-05	3	80	2	1978251
Pubmed	Evaluation of in vitro cytochrome P450 induction and inhibition activity of deoxyelephantopin, a sesquiterpene lactone from Elephantopus scaber L.	CYP1A2 CYP2D6	1.57e-05	3	80	2	23876819
Pubmed	Pharmacogenomics as an aspect of molecular autopsy for forensic pathology/toxicology: does genotyping CYP 2D6 serve as an adjunct for certifying methadone toxicity?	CYP1A2 CYP2D6	1.57e-05	3	80	2	14640293
Pubmed	PTEN-GSK3β-MOB1 axis controls neurite outgrowth in vitro and in vivo.	MOB1B MOB1A	3.13e-05	4	80	2	30069702
Pubmed	Polymorphic cytochrome P450 enzymes (CYPs) and their role in personalized therapy.	CYP1A2 CYP2D6	3.13e-05	4	80	2	24340040
Pubmed	Genetic polymorphisms of cytochrome P450 in patients with hepatitis C virus-associated hepatocellular carcinoma.	CYP1A2 CYP2D6	3.13e-05	4	80	2	16048566
Pubmed	Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein.	MOB1B MOB1A	3.13e-05	4	80	2	15197186
Pubmed	Novel nucleolar pathway connecting intracellular energy status with p53 activation.	MYBBP1A RRP8	3.13e-05	4	80	2	21471221
Pubmed	Cytochrome P450 CYP1A2, CYP2C9, CYP2C19 and CYP2D6 genes are not associated with response and remission in a sample of depressive patients.	CYP1A2 CYP2D6	3.13e-05	4	80	2	19593158
Pubmed	Six-month, prospective, longitudinal, open-label caffeine and dextromethorphan phenotyping study in children with growth hormone deficiency receiving recombinant human growth hormone replacement.	CYP1A2 CYP2D6	3.13e-05	4	80	2	18840375
Pubmed	CFTR and TMEM16A are separate but functionally related Cl- channels.	ANO9 ANO1	3.13e-05	4	80	2	22178883
Pubmed	Capillary electrophoresis to assess drug metabolism induced in vitro using single CYP450 enzymes (Supersomes): application to the chiral metabolism of mephenytoin and methadone.	CYP1A2 CYP2D6	5.20e-05	5	80	2	12900870
Pubmed	Flexibility of human cytochrome P450 enzymes: molecular dynamics and spectroscopy reveal important function-related variations.	CYP1A2 CYP2D6	5.20e-05	5	80	2	20656072
Pubmed	CYP enzyme polymorphisms and susceptibility to HCV-related chronic liver disease and liver cancer.	CYP1A2 CYP2D6	5.20e-05	5	80	2	12569554
Pubmed	Development and full validation of six inhibition assays for five major cytochrome P450 enzymes in human liver microsomes using an automated 96-well microplate incubation format and LC-MS/MS analysis.	CYP1A2 CYP2D6	5.20e-05	5	80	2	17418993
Pubmed	Biosynthesis of all-trans-retinoic acid from all-trans-retinol: catalysis of all-trans-retinol oxidation by human P-450 cytochromes.	CYP1A2 CYP2D6	5.20e-05	5	80	2	10681376
Pubmed	Analysis of 50 SNPs in CYP2D6, CYP2C19, CYP2C9, CYP3A4 and CYP1A2 by MALDI-TOF mass spectrometry in Chinese Han population.	CYP1A2 CYP2D6	5.20e-05	5	80	2	21071160
Pubmed	Combination analysis in genetic polymorphisms of drug-metabolizing enzymes CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A5 in the Japanese population.	CYP1A2 CYP2D6	5.20e-05	5	80	2	25552922
Pubmed	CYP1A2, CYP2D6, GSTM1, GSTP1, and GSTT1 gene polymorphisms in patients with bladder cancer in a Turkish population.	CYP1A2 CYP2D6	5.20e-05	5	80	2	18690546
Pubmed	YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma.	MOB1B MOB1A	5.20e-05	5	80	2	32206709
Pubmed	Molecular genetics and epigenetics of the cytochrome P450 gene family and its relevance for cancer risk and treatment.	CYP1A2 CYP2D6	5.20e-05	5	80	2	19823875
Pubmed	Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes.	CYP1A2 CYP2D6	7.79e-05	6	80	2	16401082
Pubmed	Hippo-TAZ signaling is the master regulator of the onset of triple-negative basal-like breast cancers.	MOB1B MOB1A	7.79e-05	6	80	2	35858357
Pubmed	Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice.	MOB1B MOB1A	7.79e-05	6	80	2	32716083
Pubmed	Polymorphism of metabolic genes and susceptibility to occupational chronic manganism.	CYP2D7 CYP2D6	7.79e-05	6	80	2	12171760
Pubmed	Pharmacokinetics/genotype associations for major cytochrome P450 enzymes in native and first- and third-generation Japanese populations: comparison with Korean, Chinese, and Caucasian populations.	CYP1A2 CYP2D6	7.79e-05	6	80	2	18231117
Pubmed	YAP determines the cell fate of injured mouse hepatocytes in vivo.	MOB1B MOB1A	7.79e-05	6	80	2	28681838
Pubmed	An approach based on a genome-wide association study reveals candidate loci for narcolepsy.	OR52B4 SLC18A1 ADGRB3 OR8S1 CCRL2	8.57e-05	193	80	5	20677014
Pubmed	Functional proteomic analysis of human nucleolus.	MYBBP1A NOL6 PDCD11 RRP8	1.08e-04	106	80	4	12429849
Pubmed	IFT20 links kinesin II with a mammalian intraflagellar transport complex that is conserved in motile flagella and sensory cilia.	KIFAP3 IFT52	1.09e-04	7	80	2	12821668
Pubmed	Correlates of response to Olanzapine in a North Indian Schizophrenia sample.	CYP1A2 CYP2D6	1.09e-04	7	80	2	19000940
Pubmed	MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation.	MOB1B MOB1A	1.09e-04	7	80	2	18328708
Pubmed	Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes.	CYP1A2 CYP2D6	1.09e-04	7	80	2	19219744
Pubmed	Phosphoproteome analysis of the human mitotic spindle.	MYBBP1A ERCC6 NOL6 WDR46 RRP8	1.27e-04	210	80	5	16565220
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MYBBP1A NOL6 WDR46 PDCD11 MACF1 RRP8 FRYL SPEN	1.31e-04	653	80	8	22586326
Pubmed	Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b(5) enzymes.	CYP1A2 CYP2D6	1.45e-04	8	80	2	15680923
Pubmed	Molecular characterization of human homologs of yeast MOB1.	MOB1B MOB1A	1.45e-04	8	80	2	19739119
Pubmed	The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels.	ANO9 ANO1	1.45e-04	8	80	2	21984732
Pubmed	A phenotype-genotype approach to predicting CYP450 and P-glycoprotein drug interactions with the mixed inhibitor/inducer tipranavir/ritonavir.	CYP1A2 CYP2D6	1.45e-04	8	80	2	20147896
Pubmed	Distinct strategies to make nucleosomal DNA accessible.	MYBBP1A ERCC6	1.45e-04	8	80	2	12769854
Pubmed	Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice.	MOB1B MOB1A	1.45e-04	8	80	2	26699479
Pubmed	Expression and function of epithelial anoctamins.	ANO9 ANO1	1.45e-04	8	80	2	20056604
Pubmed	Nuclear myosin 1 contributes to a chromatin landscape compatible with RNA polymerase II transcription activation.	MYBBP1A ERCC6	1.45e-04	8	80	2	26044184
Pubmed	Expression of TMEM16 paralogs during murine embryogenesis.	ANO9 ANO1	1.45e-04	8	80	2	18729231
Pubmed	ABCB1 and cytochrome P450 polymorphisms: clinical pharmacogenetics of clozapine.	CYP1A2 CYP2D6	1.45e-04	8	80	2	19593168
Pubmed	Anoctamins are a family of Ca2+-activated Cl- channels.	ANO9 ANO1	1.45e-04	8	80	2	22946059
Pubmed	Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone.	CYP1A2 CYP2D6	1.45e-04	8	80	2	18356043
Pubmed	Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues.	CYP1A2 CYP2D7 CYP2D6	1.45e-04	44	80	3	12745259
Pubmed	Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.	GHRH CYP1A2 CYP2D6 HMGCR	1.58e-04	117	80	4	18996102
Pubmed	The WSTF-SNF2h chromatin remodeling complex interacts with several nuclear proteins in transcription.	MYBBP1A ERCC6	1.86e-04	9	80	2	16603771
Pubmed	ABCB1 and cytochrome P450 genotypes and phenotypes: influence on methadone plasma levels and response to treatment.	CYP1A2 CYP2D6	1.86e-04	9	80	2	17178267
Pubmed	Nuclear myosin 1c facilitates the chromatin modifications required to activate rRNA gene transcription and cell cycle progression.	MYBBP1A ERCC6	1.86e-04	9	80	2	23555303
Pubmed	Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease.	CYP1A2 CYP2D6	2.32e-04	10	80	2	19651758
Pubmed	Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms.	CYP1A2 CYP2D6	2.32e-04	10	80	2	12865317
Pubmed	Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels.	ANO9 ANO1	2.32e-04	10	80	2	19015192
Pubmed	Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members.	ANO9 ANO1	2.32e-04	10	80	2	23532839
Pubmed	A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function.	PJVK ADGRV1	2.32e-04	10	80	2	17329413
Pubmed	Structure and function of TMEM16 proteins (anoctamins).	ANO9 ANO1	2.32e-04	10	80	2	24692353
Pubmed	Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes.	CYP1A2 CYP2D6	2.84e-04	11	80	2	15039299
Pubmed	Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population.	CYP1A2 CYP2D6	2.84e-04	11	80	2	15469410
Pubmed	Polymorphisms in xenobiotic metabolizing enzymes and diet influence colorectal adenoma risk.	CYP1A2 CYP2D6	3.40e-04	12	80	2	20375710
Pubmed	Association study of detoxification genes in age related macular degeneration.	CYP1A2 CYP2D6	3.40e-04	12	80	2	15774926
Cytoband	2q32.3	HECW2 DNAH7	1.96e-04	12	80	2	2q32.3
Cytoband	11p15.4	OR51L1 OR52B4 OR51B5 RRP8	4.27e-04	200	80	4	11p15.4
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	OR51L1 OR52B4 ANO9 OR51B5 KCNJ11 RRP8	4.66e-04	564	80	6	chr11p15
GeneFamily	Adhesion G protein-coupled receptors, subfamily B	ADGRB1 ADGRB3	3.69e-05	3	64	2	912
GeneFamily	MOB kinase activators\|STRIPAK complex	MOB1B MOB1A	2.56e-04	7	64	2	647
GeneFamily	Anoctamins	ANO9 ANO1	5.45e-04	10	64	2	865
GeneFamily	Olfactory receptors, family 8	OR8S1 OR8H1 OR8G2P	6.94e-04	49	64	3	155
GeneFamily	NLR family	NOD1 NLRP13	3.51e-03	25	64	2	666
GeneFamily	Cytochrome P450 family 2	CYP2D7 CYP2D6	6.81e-03	35	64	2	1001
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	HECW2 BAIAP3	7.19e-03	36	64	2	823
GeneFamily	Olfactory receptors, family 1	OR1J1 OR1J2	8.82e-03	40	64	2	147
GeneFamily	Olfactory receptors, family 51	OR51L1 OR51B5	1.06e-02	44	64	2	164
Coexpression	GSE46606_IRF4MID_VS_WT_CD40L_IL2_IL5_DAY1_STIMULATED_BCELL_UP	KBTBD3 ERCC6 PIAS3 METTL9 TSC22D3 WDR90 CNR2	2.19e-06	199	78	7	M9850
Drug	fenproporex	CYP1A2 CYP2D7 CYP2D6	4.00e-07	5	79	3	CID000061810
Drug	8-Methylxanthine	CYP1A2 CYP2D7 CYP2D6	7.98e-07	6	79	3	CID000087061
Drug	quinidine-N-oxide	CYP1A2 CYP2D7 CYP2D6	1.39e-06	7	79	3	CID000050979
Drug	MPBP	CYP1A2 CYP2D7 CYP2D6	2.22e-06	8	79	3	CID000129775
Drug	HCBz	CYP1A2 CYP2D7 CYP2D6	2.22e-06	8	79	3	CID000196604
Drug	p-hydroxymexiletine	CYP1A2 CYP2D7 CYP2D6	3.33e-06	9	79	3	CID000093286
Drug	8-hydroxycarteolol	CYP1A2 CYP2D7 CYP2D6	6.50e-06	11	79	3	CID000124688
Drug	AC1L3O4Q	CYP1A2 CYP2D7 CYP2D6 SPEN	8.13e-06	37	79	4	CID000119057
Drug	2-Tbmbfd	CYP1A2 CYP2D7 CYP2D6	8.65e-06	12	79	3	CID000126928
Drug	AC1L18GM	CYP1A2 CYP2D7 CYP2D6	1.12e-05	13	79	3	CID000000092
Drug	cupreidine	CYP2D7 CYP2D6	1.19e-05	2	79	2	CID000051196
Drug	3-methoxyphenethylamine	CYP2D7 CYP2D6	1.19e-05	2	79	2	CID000074866
Drug	3-hydroxylidocaine	CYP1A2 CYP2D7 CYP2D6	1.42e-05	14	79	3	CID000161824
Drug	aflatoxin Q1	CYP1A2 CYP2D7 CYP2D6	1.78e-05	15	79	3	CID000104757
Drug	4-hydroxymephenytoin	CYP1A2 CYP2D7 CYP2D6	1.78e-05	15	79	3	CID000119507
Drug	astemizole	CYP1A2 KCNH7 CYP2D7 CYP2D6	1.80e-05	45	79	4	CID000002247
Drug	alpha-hydroxymetoprolol	CYP1A2 CYP2D7 CYP2D6	2.18e-05	16	79	3	CID000114962
Drug	2cgu	CYP1A2 CYP2D7 CYP2D6 HMGCR	2.33e-05	48	79	4	CID003506204
Drug	N-desisopropylpropranolol	CYP1A2 CYP2D7 CYP2D6	2.64e-05	17	79	3	CID000159899
Drug	noralfentanil	CYP1A2 CYP2D7 CYP2D6	2.64e-05	17	79	3	CID000162172
Drug	sertindole	CYP1A2 KCNH7 CYP2D7 CYP2D6	2.74e-05	50	79	4	CID000060149
Drug	iodosylbenzene	CYP1A2 CYP2D7 CYP2D6	3.16e-05	18	79	3	CID000092125
Drug	Camphor	CYP1A2 CYP2D7 CYP2D6 SPEN	3.20e-05	52	79	4	CID000002537
Drug	Aminoquinolines	CYP1A2 CYP2D6	3.56e-05	3	79	2	ctd:D000634
Drug	N-methyl-N-benzylnitrosamine	CYP1A2 CYP2D6	3.56e-05	3	79	2	ctd:C468271
Drug	chlorpromazine N-oxide	CYP2D7 CYP2D6	3.56e-05	3	79	2	CID000443037
Drug	2,4,6-trimethylbenzaldoxime	CYP2D7 CYP2D6	3.56e-05	3	79	2	CID000283782
Drug	O-demethyl encainide	CYP2D7 CYP2D6	3.56e-05	3	79	2	CID000054736
Drug	hydroxyzine	CYP2D7 CYP2D6 TTK	3.74e-05	19	79	3	CID000003658
Drug	cumyl alcohol	CYP1A2 CYP2D7 CYP2D6	3.74e-05	19	79	3	CID000000325
Drug	1,3-benzodioxole	CYP1A2 CYP2D7 CYP2D6	3.74e-05	19	79	3	CID000009229
Drug	3C etc	CYP1A2 CYP2D7 CYP2D6	4.39e-05	20	79	3	CID000164045
Drug	3-methoxymorphinan	CYP1A2 CYP2D7 CYP2D6	4.39e-05	20	79	3	CID000001671
Drug	quetiapine	CYP1A2 KCNH7 CYP2D7 CYP2D6	4.61e-05	57	79	4	CID000005002
Drug	Racemic mixture	CYP1A2 CYP2D7 CYP2D6 ADGRV1	4.94e-05	58	79	4	CID000365464
Drug	Benzamidoxime hydrochloride	CYP1A2 CYP2D7 CYP2D6	5.11e-05	21	79	3	CID000069186
Drug	veliparib	CYP1A2 ERCC6 CYP2D6	5.90e-05	22	79	3	ctd:C521013
Drug	terfenadine	CYP1A2 KCNH7 CYP2D7 CYP2D6	6.03e-05	61	79	4	CID000005405
Drug	Pancuronium bromide [15500-66-0]; Down 200; 5.4uM; PC3; HT_HG-U133A	CYP1A2 MYBBP1A SLC9A2 RAD54B MUC1 DNAH7	6.22e-05	196	79	6	4570_DN
Drug	perazine	CYP1A2 CYP2D7 CYP2D6	6.77e-05	23	79	3	CID000004744
Drug	C07611	CYP1A2 CYP2D7 CYP2D6	6.77e-05	23	79	3	CID000441299
Drug	AC1L2K1Q	CYP1A2 CYP2D7 CYP2D6	6.77e-05	23	79	3	CID000022258
Drug	fenproporex	CYP1A2 CYP2D6	7.10e-05	4	79	2	ctd:C026013
Drug	4,4'-difluorobenzophenone	CYP2D7 CYP2D6	7.10e-05	4	79	2	CID000009582
Drug	N,N-diethyl-3-hydroxymethylbenzamide	CYP1A2 CYP2D6	7.10e-05	4	79	2	ctd:C454677
Drug	4-(methylsulfinyl)phenol	CYP1A2 CYP2D6	7.10e-05	4	79	2	ctd:C044390
Drug	7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine	CYP1A2 CYP2D6	7.10e-05	4	79	2	ctd:C556297
Drug	Z-10	CYP2D7 CYP2D6	7.10e-05	4	79	2	CID000477529
Drug	1-(1-phenylcyclohexyl)-4-piperidinol	CYP2D7 CYP2D6	7.10e-05	4	79	2	CID000098840
Drug	1-(2-methyl-4-methoxyphenyl)-4-((2-hydroxyethyl)amino)-6-trifluoromethoxy-2,3-dihydropyrrolo(3,2-c)quinoline	CYP1A2 CYP2D6	7.10e-05	4	79	2	ctd:C439392
Drug	desethylaprindine	CYP2D7 CYP2D6	7.10e-05	4	79	2	CID000162697
Drug	flutriafol	CYP1A2 KCNH7	7.10e-05	4	79	2	CID000091727
Drug	AC1L89QG	CYP1A2 CYP2D7 CYP2D6 CNR2	9.24e-05	68	79	4	CID000323970
Drug	dopamine quinone	CYP1A2 CYP2D7 CYP2D6 SLC18A1	9.78e-05	69	79	4	CID000162602
Drug	arene oxide	CYP1A2 CYP2D7 CYP2D6	9.87e-05	26	79	3	CID000104944
Drug	MEGX	CYP1A2 CYP2D7 CYP2D6	9.87e-05	26	79	3	CID000024415
Drug	4-bromophenol	CYP1A2 CYP2D7 CYP2D6 CNR2	1.03e-04	70	79	4	CID000007808
Drug	C14845	CYP1A2 CYP2D7 CYP2D6	1.11e-04	27	79	3	CID011954064
Drug	BP-9,10-oxide	CYP1A2 CYP2D7 CYP2D6	1.11e-04	27	79	3	CID000037456
Drug	Brn 4136738	CYP1A2 CYP2D7 CYP2D6	1.11e-04	27	79	3	CID000050331
Drug	pyrimidone	CYP1A2 CYP2D7 CYP2D6	1.11e-04	27	79	3	CID000068401
Drug	dimethocaine	CYP1A2 CYP2D6	1.18e-04	5	79	2	ctd:C066888
Drug	eptapirone	CYP2D7 CYP2D6	1.18e-04	5	79	2	CID000208928
Drug	Koe 1801	CYP2D7 CYP2D6	1.18e-04	5	79	2	CID000129632
Drug	N,N-diallyl-5-methoxytryptamine	CYP1A2 CYP2D6	1.18e-04	5	79	2	ctd:C578955
Drug	lephetamine	CYP1A2 CYP2D6	1.18e-04	5	79	2	ctd:C011896
Drug	bufuralol	CYP1A2 CYP2D6	1.18e-04	5	79	2	ctd:C010831
Drug	N-(2-amino-3-methyl-n-butyl)-3-((bis-4-fluorophenyl)methoxy)tropane	CYP1A2 CYP2D6	1.18e-04	5	79	2	ctd:C534983
Drug	4-ipomeanol	CYP1A2 CYP2D6	1.18e-04	5	79	2	ctd:C001470
Drug	2Cmp	CYP2D7 CYP2D6	1.18e-04	5	79	2	CID000023392
Drug	amitriptyline N-oxide	CYP1A2 CYP2D6	1.18e-04	5	79	2	ctd:C006566
Drug	L-754,394	CYP2D7 CYP2D6	1.18e-04	5	79	2	CID005481990
Drug	imipramine N-oxide	CYP1A2 CYP2D6	1.18e-04	5	79	2	ctd:C002921
Drug	oxosparteine	CYP2D7 CYP2D6	1.18e-04	5	79	2	CID000097492
Drug	threohydrobupropion	CYP2D7 CYP2D6	1.18e-04	5	79	2	CID000000445
Drug	4-hydroxyochratoxin A	CYP2D7 CYP2D6	1.18e-04	5	79	2	CID000114713
Drug	N-ethyl-1,2-diphenylethylamine	CYP1A2 CYP2D6	1.18e-04	5	79	2	ctd:C000598690
Drug	9-OH-BaP-4,5-oxide	CYP1A2 CYP2D7 CYP2D6	1.24e-04	28	79	3	CID000115064
Drug	encainide	CYP1A2 CYP2D7 CYP2D6	1.24e-04	28	79	3	CID000048040
Drug	dihydralazine	CYP1A2 CYP2D7 CYP2D6	1.38e-04	29	79	3	CID000010230
Drug	NSC117862	CYP1A2 CYP2D7 CYP2D6	1.53e-04	30	79	3	CID000003648
Drug	11-H-14,15-EETA	CYP1A2 CYP2D7 CYP2D6	1.53e-04	30	79	3	CID011954058
Drug	19-hydroxytestosterone	CYP1A2 CYP2D7 CYP2D6	1.53e-04	30	79	3	CID000150968
Drug	piptal	CYP1A2 CYP2D7 CYP2D6	1.53e-04	30	79	3	CID000031322
Drug	milnacipran	CYP1A2 CYP2D7 CYP2D6	1.53e-04	30	79	3	CID000055480
Drug	delta3-piperidine	CYP1A2 CYP2D7 CYP2D6	1.53e-04	30	79	3	CID000012750
Drug	thioridazine	CYP1A2 KCNH7 CYP2D7 CYP2D6	1.66e-04	79	79	4	CID000005452
Drug	1-methylxanthine (1-MX	CYP1A2 CYP2D7 CYP2D6	1.68e-04	31	79	3	CID000080220
Drug	paliperidone	CYP1A2 CYP2D7 CYP2D6	1.68e-04	31	79	3	CID000115237
Drug	clomipramine	CYP1A2 CYP2D7 CYP2D6 SLC18A1	1.74e-04	80	79	4	CID000002801
Drug	AC1L45F6	CYP2D7 CYP2D6	1.77e-04	6	79	2	CID000150982
Drug	3,5-xylenol	CYP1A2 CYP2D6	1.77e-04	6	79	2	ctd:C016834
Drug	KRM1674	CYP2D7 CYP2D6	1.77e-04	6	79	2	CID000126235
Drug	N,N-diisopropyltryptamine	CYP1A2 CYP2D6	1.77e-04	6	79	2	ctd:C033695
Drug	5-dehydrosparteine	CYP2D7 CYP2D6	1.77e-04	6	79	2	CID000160614
Drug	Methoxydimethyltryptamines	CYP1A2 CYP2D6	1.77e-04	6	79	2	ctd:D008732
Drug	nitroguanidine	CYP2D7 CYP2D6	1.77e-04	6	79	2	CID000011174
Drug	tegaserod	CYP1A2 CYP2D6	1.77e-04	6	79	2	ctd:C105050
Drug	5-methoxyindole	CYP1A2 CYP2D6	1.77e-04	6	79	2	ctd:C487413
Drug	10-hydroxyochratoxin A	CYP2D7 CYP2D6	1.77e-04	6	79	2	CID000135115
Disease	Ondansetron response	CYP1A2 CYP2D6	2.07e-05	3	78	2	cv:CN417142
Disease	Clozapine response	CYP1A2 CYP2D6	4.12e-05	4	78	2	cv:CN077971
Disease	solanidine measurement	CYP2D7 CYP2D6	4.12e-05	4	78	2	EFO_0800966
Disease	upper face morphology measurement	GPR137B MACF1 MLLT3 ADGRV1	1.30e-04	97	78	4	EFO_0010949
Disease	sickle cell anemia	OR51L1 OR51B5	1.91e-04	8	78	2	MONDO_0011382
Disease	Schizophrenia and related disorders	CYP1A2 CYP2D6	2.45e-04	9	78	2	C0809983
Disease	unipolar depression, response to selective serotonin reuptake inhibitor	CYP2D7 CYP2D6	1.83e-03	24	78	2	EFO_0003761, EFO_0005658
Disease	methionine measurement	GPR137B ADGRV1	2.15e-03	26	78	2	EFO_0009771
Disease	hearing impairment	ERCC6 PJVK ADGRV1	2.26e-03	98	78	3	C1384666
Disease	cholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement	SLC18A1 MACF1 MUC1	2.60e-03	103	78	3	EFO_0008595, EFO_0020944

Protein segments in the cluster

Peptide	Gene	Start	Entry
IAFFLSTFKEHFSLS	CCRL2	256	O00421
RFHFTLEALVSFFHA	BAIAP3	946	O94812
CTLVAAFLHFFFLSS	ADGRB1	1011	O14514
CTTTTAFLHFFFLAS	ADGRB3	941	O60242
DFSISFEFRSLLHSQ	COQ10B	181	Q9H8M1
FHITNTTFDFDLCSL	MLLT3	536	P42568
HFAEVTENFAFSLLT	ADGRV1	5711	Q8WXG9
LLNFCFHAALTFTVF	ADGRA1	56	Q86SQ6
ILSTSFNFSQLFHSD	ABCA13	866	Q86UQ4
TIRFFTLQFFTHFSS	ANO9	421	A1A5B4
FLASVVFACSFVNFH	CNR2	81	P34972
FNSQHSSFFIFLLSS	RAD54B	706	Q9Y620
FILETFRHSSFLPFT	CYP1A2	371	P05177
FSTCSSHILAVAVFF	OR8G2P	251	Q6IF36
FVQHHFSLLFKSSDF	KBTBD3	176	Q8NAB2
HFVFNNFFTSIALLD	ERCC6	816	P0DP91
AFFVDHNSRTTTFID	HECW2	1001	Q9P2P5
FFLSHLALTDISFSS	OR1J2	61	Q8NGS2
FTFFGTSFLFITSHF	INPP5E	411	Q9NRR6
FFFHTHSTVTTTLAL	GPR179	611	Q6PRD1
FSDHFLTNLELTFNL	KCNH7	851	Q9NS40
FSSFVFSTVVIHFLD	HMGCR	101	P04035
LSTGVSFFFLSFHIS	MUC1	1036	P15941
SFFFLSFHISNLQFN	MUC1	1041	P15941
VTSIHSFSSAFLFSI	KCNJ11	111	Q14654
VFTGAFHALSFLLSF	GPR26	171	Q8NDV2
FSQAYFIHSLSFLES	OR51B5	96	Q9H339
AQLFFIHTFTFLESS	OR51L1	101	Q8NGJ5
TQLFFIHSTFISESG	OR52B4	101	Q8NGK2
SSAVFTFHVFSRLFQ	FRYL	2701	O94915
ADFHQAFSVVFLDSS	NOL6	406	Q9H6R4
FHLTLQAFFTAFFLV	NOD1	516	Q9Y239
TFSFAFNHELTDVTS	MACF1	651	O94854
FIQLYHSFVSSVFSL	METTL9	96	Q9H1A3
EAHLNTSFKHFIFFV	MOB1B	176	Q7L9L4
SHLFDNPATVFFSVF	ANO1	401	Q5XXA6
FESEFVHIVAISFTS	ATP9A	946	O75110
SHFLSVSIFCDSLLF	OR5K3	241	A6NET4
FFLSHLALTDISFSS	OR1J1	61	Q8NGS3
VIGFTISALHSSFTF	OR2J2	151	O76002
IEDFHKQSFFFTHLL	CYFIP2	616	Q96F07
LTEQVARFCLFHSFF	MYBBP1A	471	Q9BQG0
ILLCHFLNFASTSFF	GPRC6A	636	Q5T6X5
FSFHFNLYSSILFLT	OXGR1	111	Q96P68
FHFSLGSTSFLILTD	OR6V1	101	Q8N148
LTHRSFVSEFHNFLS	PLA2G4E	646	Q3MJ16
FLLTHVDVLFSDTFT	ARHGAP33	501	O14559
HQRFSTFAGFLLFET	C1QTNF3	231	Q9BXJ4
FDLSIFQLDTTSFHS	IFT52	291	Q9Y366
DSPTLTRFFTFHFIL	MT-CYB	171	P00156
FFTSLLQHFSFSVPT	CYP2D6	456	P10635
FSISFEFRSLLHSQL	COQ10A	191	Q96MF6
SFHTSTIDLSKSFFV	DNAH7	2536	Q8WXX0
ALFAFFLETNHFRTA	GLRA2	11	P23416
TFAIESFRTFQSHFT	FAM186A	2006	A6NE01
FFCFSSFSQFHGLIT	KIFAP3	201	Q92845
FLAVNTFHVRSSFDF	OR13C3	11	Q8NGS6
FFLTHLSFIDLSYST	OR8H1	61	Q8NGG4
FILSFSQNKSVHSFD	GPR137B	256	O60478
HFDAVLVSFINFFTS	SLC6A15	331	Q9H2J7
QLHNFSISFFSSLLG	TSC22D3	16	Q99576
EAHLNTSFKHFIFFV	MOB1A	176	Q9H8S9
FLSHLSFVDLCFSSN	OR5M8	61	Q8NGP6
TLLHFDASFFSIVQN	SURF4	171	O15260
FFLSHLSFVDLCFSS	OR8S1	61	Q8NH09
FFFVILTLSNSSHCS	GHRH	6	P01286
VFDTAFSRHFSLLES	CIAO3	151	Q9H6Q4
LFLFFTSLLQHFSFS	CYP2D7	471	A0A087X1C5
SSQRFEEAHFTFALT	PIAS3	151	Q9Y6X2
AAFSLTSHLNDTFRF	PDCD11	951	Q14690
AHTDFDVQAFRVTFF	WDR90	501	Q96KV7
FASRFLHSSIFEQDS	SPEN	1526	Q96T58
FFLSNLSFIDICHSS	OR4E2	61	Q8NGC2
FPAHTTIAFSVFELF	PJVK	201	Q0ZLH3
FLGFIAAFTTRFTHN	SLC9A2	291	Q9UBY0
QSHSFSFTFLEDLQA	SERPINB13	216	Q9UIV8
SKDLTNSHFFLFDFQ	RRP8	416	O43159
FHFLLATASETGFLT	WDR46	286	O15213
KFAFVHISFAQFELS	TTK	141	P33981
HALASPAFSTIFSFF	SLC18A1	71	P54219
VFSSFSFLVQHQSIH	ZNF302	456	Q9NR11
CTTFTHLSFQEFFAA	NLRP13	531	Q86W25