Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	actin-based cell projection	TMC2 UBE2Q1 MYO1D MTM1 MTTP ERMN	1.19e-04	278	58	6	GO:0098858
GeneOntologyCellularComponent	smooth endoplasmic reticulum	MYO1D APOB RYR2	2.83e-04	46	58	3	GO:0005790
Domain	Vitellinogen_b-sht_N	MTTP APOB	8.83e-06	2	56	2	IPR015816
Domain	Lipid_transp_b-sht_shell	MTTP APOB	8.83e-06	2	56	2	IPR015819
Domain	LPD_N	MTTP APOB	8.83e-06	2	56	2	SM00638
Domain	Lipid_transpt_N	MTTP APOB	8.83e-06	2	56	2	IPR001747
Domain	-	MTTP APOB	8.83e-06	2	56	2	2.30.230.10
Domain	-	MTTP APOB	8.83e-06	2	56	2	1.25.10.20
Domain	VITELLOGENIN	MTTP APOB	8.83e-06	2	56	2	PS51211
Domain	Vitellogenin_N	MTTP APOB	8.83e-06	2	56	2	PF01347
Domain	Vitellinogen_superhlx	MTTP APOB	2.64e-05	3	56	2	IPR011030
Domain	TPR_REGION	TTC39B RPAP3 TTC14 CLUH GTF3C3	1.34e-04	165	56	5	PS50293
Domain	TPR	TTC39B RPAP3 TTC14 CLUH GTF3C3	1.34e-04	165	56	5	PS50005
Domain	-	TTC39B RPAP3 TTC14 CLUH GTF3C3	3.85e-04	207	56	5	1.25.40.10
Domain	TPR_8	TTC39B RPAP3 GTF3C3	5.38e-04	53	56	3	PF13181
Domain	TPR	TTC39B RPAP3 TTC14 GTF3C3	6.04e-04	129	56	4	SM00028
Domain	TPR-like_helical_dom	TTC39B RPAP3 TTC14 CLUH GTF3C3	6.59e-04	233	56	5	IPR011990
Domain	TPR_repeat	TTC39B RPAP3 TTC14 GTF3C3	6.78e-04	133	56	4	IPR019734
Domain	Myotubularin-like_Pase_dom	MTM1 SBF2	7.85e-04	14	56	2	IPR010569
Domain	uDENN	DENND5B SBF2	7.85e-04	14	56	2	SM00800
Domain	PPASE_MYOTUBULARIN	MTM1 SBF2	7.85e-04	14	56	2	PS51339
Domain	Myotubularin_fam	MTM1 SBF2	7.85e-04	14	56	2	IPR030564
Domain	Myotub-related	MTM1 SBF2	7.85e-04	14	56	2	PF06602
Domain	uDENN	DENND5B SBF2	9.04e-04	15	56	2	PF03456
Domain	UDENN	DENND5B SBF2	1.03e-03	16	56	2	PS50946
Domain	DDENN	DENND5B SBF2	1.03e-03	16	56	2	PS50947
Domain	GRAM	MTM1 SBF2	1.03e-03	16	56	2	SM00568
Domain	DENN	DENND5B SBF2	1.03e-03	16	56	2	SM00799
Domain	dDENN	DENND5B SBF2	1.03e-03	16	56	2	SM00801
Domain	DENN	DENND5B SBF2	1.03e-03	16	56	2	PF02141
Domain	dDENN_dom	DENND5B SBF2	1.03e-03	16	56	2	IPR005112
Domain	uDENN_dom	DENND5B SBF2	1.03e-03	16	56	2	IPR005113
Domain	dDENN	DENND5B SBF2	1.03e-03	16	56	2	PF03455
Domain	DENN	DENND5B SBF2	1.03e-03	16	56	2	PS50211
Domain	DENN_dom	DENND5B SBF2	1.03e-03	16	56	2	IPR001194
Domain	GRAM	MTM1 SBF2	1.96e-03	22	56	2	PF02893
Domain	GRAM	MTM1 SBF2	1.96e-03	22	56	2	IPR004182
Domain	TPR_1	RPAP3 TTC14 GTF3C3	2.49e-03	90	56	3	PF00515
Domain	TPR_1	RPAP3 TTC14 GTF3C3	2.49e-03	90	56	3	IPR001440
Pathway	REACTOME_VLDL_ASSEMBLY	MTTP APOB	9.04e-05	5	43	2	M27760
Pathway	REACTOME_VLDL_ASSEMBLY	MTTP APOB	9.04e-05	5	43	2	MM15505
Pathway	REACTOME_LDL_REMODELING	MTTP APOB	1.35e-04	6	43	2	M42520
Pathway	REACTOME_CHYLOMICRON_ASSEMBLY	MTTP APOB	3.23e-04	9	43	2	MM15558
Pathway	REACTOME_CHYLOMICRON_ASSEMBLY	MTTP APOB	4.03e-04	10	43	2	M27838
Pathway	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE	INPP4A MTM1 SBF2	5.57e-04	53	43	3	M662
Pathway	WP_FEMALE_STEROID_HORMONES_IN_CARDIOMYOCYTE_ENERGY_METABOLISM	MTTP APOB	8.08e-04	14	43	2	M48059
Pathway	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE	INPP4A MTM1	9.31e-04	15	43	2	MM14643
Pathway	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE	INPP4A MTM1	1.06e-03	16	43	2	M639
Pathway	WP_METABOLIC_PATHWAY_OF_LDL_HDL_AND_TG_INCLUDING_DISEASES	MTTP APOB	1.20e-03	17	43	2	M39747
Pathway	REACTOME_PLASMA_LIPOPROTEIN_ASSEMBLY	MTTP APOB	1.20e-03	17	43	2	MM15561
Pubmed	Structure-function analyses of microsomal triglyceride transfer protein missense mutations in abetalipoproteinemia and hypobetalipoproteinemia subjects.	MTTP APOB	2.83e-06	2	59	2	27487388
Pubmed	A deficiency of microsomal triglyceride transfer protein reduces apolipoprotein B secretion.	MTTP APOB	2.83e-06	2	59	2	10713055
Pubmed	Identification of patients with abetalipoproteinemia and homozygous familial hypobetalipoproteinemia in Tunisia.	MTTP APOB	2.83e-06	2	59	2	19056372
Pubmed	Novel mutations in abetalipoproteinaemia and homozygous familial hypobetalipoproteinaemia.	MTTP APOB	2.83e-06	2	59	2	18027103
Pubmed	Human placenta secretes apolipoprotein B-100-containing lipoproteins.	MTTP APOB	2.83e-06	2	59	2	15504742
Pubmed	Homozygous MTTP and APOB mutations may lead to hepatic steatosis and fibrosis despite metabolic differences in congenital hypocholesterolemia.	MTTP APOB	2.83e-06	2	59	2	24842304
Pubmed	Relationship between Amphipathic β Structures in the β1 Domain of Apolipoprotein B and the Properties of the Secreted Lipoprotein Particles in McA-RH7777 Cells.	MTTP APOB	2.83e-06	2	59	2	28702990
Pubmed	Hypobetalipoproteinemia with an apparently recessive inheritance due to a "de novo" mutation of apolipoprotein B.	MTTP APOB	2.83e-06	2	59	2	14732481
Pubmed	Microsomal triglyceride transfer protein binding and lipid transfer activities are independent of each other, but both are required for secretion of apolipoprotein B lipoproteins from liver cells.	MTTP APOB	2.83e-06	2	59	2	11358959
Pubmed	A common binding site on the microsomal triglyceride transfer protein for apolipoprotein B and protein disulfide isomerase.	MTTP APOB	2.83e-06	2	59	2	9915855
Pubmed	Microsomal triglyceride transfer protein gene expression and ApoB secretion are inhibited by bitter melon in HepG2 cells.	MTTP APOB	2.83e-06	2	59	2	15795421
Pubmed	Microsomal triglyceride transfer protein activity is not required for the initiation of apolipoprotein B-containing lipoprotein assembly in McA-RH7777 cells.	MTTP APOB	2.83e-06	2	59	2	17690102
Pubmed	Microsomal triglyceride transfer protein enhances cellular cholesteryl esterification by relieving product inhibition.	MTTP APOB	8.48e-06	3	59	2	18502767
Pubmed	Conditional hepatocyte ablation of PDIA1 uncovers indispensable roles in both APOB and MTTP folding to support VLDL secretion.	MTTP APOB	8.48e-06	3	59	2	38211723
Pubmed	Complex genetic architecture in severe hypobetalipoproteinemia.	MTTP APOB	8.48e-06	3	59	2	29540175
Pubmed	Novel Abetalipoproteinemia Missense Mutation Highlights the Importance of the N-Terminal β-Barrel in Microsomal Triglyceride Transfer Protein Function.	MTTP APOB	8.48e-06	3	59	2	26224785
Pubmed	ApoB100-LDL acts as a metabolic signal from liver to peripheral fat causing inhibition of lipolysis in adipocytes.	MTTP APOB	8.48e-06	3	59	2	19020660
Pubmed	Lowering plasma cholesterol levels halts progression of aortic valve disease in mice.	MTTP APOB	8.48e-06	3	59	2	19433756
Pubmed	Phosphatase and tensin homolog (PTEN) regulates hepatic lipogenesis, microsomal triglyceride transfer protein, and the secretion of apolipoprotein B-containing lipoproteins.	MTTP APOB	8.48e-06	3	59	2	19026012
Pubmed	Apolipoprotein B-related gene expression and ultrastructural characteristics of lipoprotein secretion in mouse yolk sac during embryonic development.	MTTP APOB	8.48e-06	3	59	2	10553000
Pubmed	Diabetes adversely affects macrophages during atherosclerotic plaque regression in mice.	MTTP APOB	8.48e-06	3	59	2	21562077
Pubmed	Vascular function during prolonged progression and regression of atherosclerosis in mice.	MTTP APOB	8.48e-06	3	59	2	23307875
Pubmed	Microsomal triglyceride transfer protein expression during mouse development.	MTTP APOB	8.48e-06	3	59	2	10744773
Pubmed	Eliminating atherogenesis in mice by switching off hepatic lipoprotein secretion.	MTTP APOB	8.48e-06	3	59	2	12628954
Pubmed	Secretion of atherogenic risk factor apolipoprotein B-100 is increased by a potential mechanism of JNK/PKC-mediated insulin resistance in liver cells.	MTTP APOB	8.48e-06	3	59	2	17647275
Pubmed	Plasma cholesterol-induced lesion networks activated before regression of early, mature, and advanced atherosclerosis.	MTTP APOB	8.48e-06	3	59	2	24586211
Pubmed	Regulatory effects of arachidonate 5-lipoxygenase on hepatic microsomal TG transfer protein activity and VLDL-triglyceride and apoB secretion in obese mice.	MTTP APOB	1.69e-05	4	59	2	18645210
Pubmed	Novel missense MTTP gene mutations causing abetalipoproteinemia.	MTTP APOB	1.69e-05	4	59	2	25108285
Pubmed	Epigenome-guided analysis of the transcriptome of plaque macrophages during atherosclerosis regression reveals activation of the Wnt signaling pathway.	MTTP APOB	1.69e-05	4	59	2	25474352
Pubmed	Reversal of hyperlipidemia with a genetic switch favorably affects the content and inflammatory state of macrophages in atherosclerotic plaques.	MTTP APOB	1.69e-05	4	59	2	21339485
Pubmed	Poliovirus Receptor-Related 2: A Cholesterol-Responsive Gene Affecting Atherosclerosis Development by Modulating Leukocyte Migration.	MTTP APOB	1.69e-05	4	59	2	28062492
Pubmed	Molecular analysis of APOB, SAR1B, ANGPTL3, and MTTP in patients with primary hypocholesterolemia in a clinical laboratory setting: Evidence supporting polygenicity in mutation-negative patients.	MTTP APOB	1.69e-05	4	59	2	30782561
Pubmed	ApoB100 is required for increased VLDL-triglyceride secretion by microsomal triglyceride transfer protein in ob/ob mice.	MTTP APOB	1.69e-05	4	59	2	18519977
Pubmed	Endosomal phosphoinositides and human diseases.	MTM1 SBF2	1.69e-05	4	59	2	18429927
Pubmed	Association between shear stress and platelet-derived transforming growth factor-β1 release and activation in animal models of aortic valve stenosis.	MTTP APOB	1.69e-05	4	59	2	24903096
Pubmed	miR33 inhibition overcomes deleterious effects of diabetes mellitus on atherosclerosis plaque regression in mice.	MTTP APOB	1.69e-05	4	59	2	25201910
Pubmed	The influence of molecular biology on our understanding of lipoprotein metabolism and the pathobiology of atherosclerosis.	MTTP APOB	1.69e-05	4	59	2	7741021
Pubmed	Transcriptional profiling uncovers a network of cholesterol-responsive atherosclerosis target genes.	MTTP APOB	1.69e-05	4	59	2	18369455
Pubmed	Chemokine receptors CXCR2 and CX3CR1 differentially regulate functional responses of bone-marrow endothelial progenitors during atherosclerotic plaque regression.	MTTP APOB	2.82e-05	5	59	2	25765938
Pubmed	Characterization of lipoproteins in human placenta and fetal circulation as well as gestational changes in lipoprotein assembly and secretion in human and mouse placentas.	MTTP APOB	2.82e-05	5	59	2	37315736
Pubmed	Microsomal triacylglycerol transfer protein is required for lumenal accretion of triacylglycerol not associated with ApoB, as well as for ApoB lipidation.	MTTP APOB	2.82e-05	5	59	2	12072432
Pubmed	PtdIns5P regulation through evolution: roles in membrane trafficking?	MTM1 SBF2	4.23e-05	6	59	2	18774718
Pubmed	Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function.	TLR3 SMCR8	4.23e-05	6	59	2	30442666
Pubmed	Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation state.	MTTP APOB	4.23e-05	6	59	2	9694898
Pubmed	FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice.	MTTP APOB	4.23e-05	6	59	2	18497885
Pubmed	Genetic polymorphisms and lipoprotein responses to diets.	MTTP APOB	5.91e-05	7	59	2	12691171
Pubmed	Atherosclerosis quantitative trait loci are sex- and lineage-dependent in an intercross of C57BL/6 and FVB/N low-density lipoprotein receptor-/- mice.	MTTP APOB	5.91e-05	7	59	2	16380418
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	ZBTB33 RPAP3 INPP4A HUWE1 TASOR GTF3C3	7.65e-05	418	59	6	34709266
Pubmed	Reliance of host cholesterol metabolic pathways for the life cycle of hepatitis C virus.	MTTP APOB	7.87e-05	8	59	2	17784784
Pubmed	Rank-based genome-wide analysis reveals the association of ryanodine receptor-2 gene variants with childhood asthma among human populations.	MKLN1 RYR2	1.01e-04	9	59	2	23829686
Pubmed	Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human.	MTM1 SBF2	1.26e-04	10	59	2	9736772
Pubmed	AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis.	MTM1 RYR2	1.26e-04	10	59	2	18434328
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RPL34 MYO1D CEBPZ SPTA1 MTTP APOB ALCAM NEB TASOR RYR2	1.43e-04	1442	59	10	35575683
Pubmed	Nutrigenetics: links between genetic background and response to Mediterranean-type diets.	MTTP APOB	1.54e-04	11	59	2	19689828
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	EXOC5 SRGAP1 SPTA1 RYR2	1.94e-04	168	59	4	30631154
Pubmed	The environmental and genetic evidence for the association of hyperlipidemia and hypertension.	MTTP APOB	2.18e-04	13	59	2	19155782
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	ZBTB33 ARHGEF10 RPAP3 CEBPZ HUWE1 TASOR CLUH	2.37e-04	733	59	7	34672954
Pubmed	Maternal diabetes causes coordinated down-regulation of genes involved with lipid metabolism in the murine fetal heart.	MTTP APOB	2.54e-04	14	59	2	18502258
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	ZBTB33 RPAP3 CEBPZ HUWE1 PHAX GTF3C3	3.34e-04	549	59	6	38280479
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	ZBTB33 APOB HUWE1 SMCR8 TASOR GTF3C3 RYR2	3.36e-04	777	59	7	35844135
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	UBE2Q1 SBF2 KBTBD8 TTC14 MKLN1 APOB HUWE1 TASOR	4.70e-04	1084	59	8	11544199
Pubmed	Teashirt 1 (Tshz1) is essential for the development, survival and function of hypoglossal and phrenic motor neurons in mouse.	HOXC5 ALCAM	4.75e-04	19	59	2	31427287
Pubmed	Feto-maternal cholesterol transport regulated by β-Klotho-FGF15 axis is essential for fetal growth.	MTTP APOB	4.75e-04	19	59	2	37541847
Pubmed	Sustained Hox5 gene activity is required for respiratory motor neuron development.	HOXC5 ALCAM	5.27e-04	20	59	2	23103965
Pubmed	Loss of the PlagL2 transcription factor affects lacteal uptake of chylomicrons.	MTTP APOB	6.39e-04	22	59	2	17983586
Pubmed	Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry.	EXOC5 RPL34 MYO1D CEBPZ MTM1	6.67e-04	411	59	5	36652389
Pubmed	Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity.	MTTP APOB	7.62e-04	24	59	2	25009997
Pubmed	Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease.	MYO1D MTTP APOB HUWE1	7.95e-04	244	59	4	28902428
Pubmed	Gamma protocadherins are required for survival of spinal interneurons.	PCDHA11 ALCAM	8.96e-04	26	59	2	12467588
Pubmed	Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.	NEB RYR2	9.66e-04	27	59	2	18468998
Pubmed	Phrenic-specific transcriptional programs shape respiratory motor output.	HOXC5 ALCAM	9.66e-04	27	59	2	31944180
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	DENND5B RPL34 UBE2Q1 SHCBP1 TTC14 CLUH	1.09e-03	689	59	6	36543142
Pubmed	Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population.	TTC39B APOB	1.12e-03	29	59	2	20972250
Pubmed	Multimodal Hox5 activity generates motor neuron diversity.	HOXC5 ALCAM	1.12e-03	29	59	2	39289460
Pubmed	Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.	SBF2 APOB	1.19e-03	30	59	2	19936222
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND5B SBF2 SMCR8	3.41e-05	25	46	3	504
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	TTC39B RPAP3 TTC14 GTF3C3	2.06e-04	115	46	4	769
GeneFamily	Myotubularins\|Phosphoinositide phosphatases	MTM1 SBF2	6.51e-04	15	46	2	903
Coexpression	GSE41867_DAY6_VS_DAY15_LCMV_CLONE13_EFFECTOR_CD8_TCELL_UP	PLB1 PPDPFL TMC2 SPTA1 KIF19	6.21e-05	189	58	5	M9512
Coexpression	GSE41867_DAY15_EFFECTOR_VS_DAY30_MEMORY_CD8_TCELL_LCMV_ARMSTRONG_DN	SETDB2 PLB1 PPDPFL MTM1 KBTBD8	6.37e-05	190	58	5	M9521
Coexpression	PGF_UP.V1_UP	CEBPZ MTM1 MKLN1 REV3L TASOR	6.37e-05	190	58	5	M2674
Coexpression	GSE369_IFNG_KO_VS_WT_LIVER_DN	RPAP3 CEBPZ MTM1 KBTBD8 CLUH	8.12e-05	200	58	5	M5972
Coexpression	GSE19888_ADENOSINE_A3R_INH_VS_TCELL_MEMBRANES_ACT_MAST_CELL_DN	TTC39B TMC2 MTM1 DCST2 ERMN	8.12e-05	200	58	5	M7350
Coexpression	GSE2770_UNTREATED_VS_TGFB_AND_IL12_TREATED_ACT_CD4_TCELL_48H_DN	EXOC5 ZBTB33 MKLN1 B4GALNT2 HUWE1	8.12e-05	200	58	5	M6056
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	EXOC5 ZBTB33 SBF2 HUWE1 SMCR8 GTF3C3	1.94e-07	193	58	6	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	Sepsis-URO-Lymphocyte-T/NK-CD4+_CTL\|URO / Disease, condition lineage and cell class	RPL34 HOXC5 KIF19 DCST2 RYR2	5.95e-06	198	58	5	c53405a8d082fbd10131a6ec88b69fdd835f2925
ToppCell	Sepsis-Int-URO-Lymphocyte-B-B_intermediate\|Int-URO / Disease, condition lineage and cell class	DENND5B RPL34 ARHGEF10 SLC9A7 NEB	6.25e-06	200	58	5	221dd8d8851c47f2202ba848de3a041b17b1db3f
Computational	Blood cells and cancer expression clusters.	RPAP3 CEBPZ REV3L PHAX CLUH ERMN	7.78e-04	407	30	6	MODULE_532
Computational	Pol II transcription.	SETDB2 ZBTB33 TTC14	9.87e-04	71	30	3	MODULE_308
Computational	Genes in the cancer module 459.	RPAP3 CEBPZ REV3L PHAX CLUH ERMN	1.05e-03	431	30	6	MODULE_459
Computational	Genes in the cancer module 378.	RPAP3 CEBPZ REV3L PHAX CLUH ERMN	1.10e-03	435	30	6	MODULE_378
Computational	Genes in the cancer module 317.	RPAP3 CEBPZ REV3L PHAX CLUH ERMN	1.17e-03	440	30	6	MODULE_317
Computational	Genes in the cancer module 255.	RPAP3 CEBPZ REV3L PHAX CLUH ERMN	1.31e-03	450	30	6	MODULE_255
Computational	Blood cells and cancer expression cancer.	RPAP3 CEBPZ REV3L PHAX CLUH ERMN	1.61e-03	468	30	6	MODULE_179
Computational	Genes in the cancer module 136.	CEBPZ MTTP REV3L PHAX CLUH ERMN	2.05e-03	491	30	6	MODULE_136
Disease	response to methotrexate, aspartate aminotransferase measurement	THSD4 PLB1 TMC2	2.32e-06	14	56	3	EFO_0004736, GO_0031427
Disease	fecal incontinence	PLB1 CDH7	3.52e-05	5	56	2	EFO_0009523
Disease	familial hypercholesterolemia (is_implicated_in)	MTTP APOB	1.58e-04	10	56	2	DOID:13810 (is_implicated_in)
Disease	cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	TTC39B SBF2 MTTP APOB PMFBP1	1.79e-04	276	56	5	EFO_0004612, EFO_0020943
Disease	level of Diacylglycerol (18:1_18:1) in blood serum	B4GALNT2 APOB	1.92e-04	11	56	2	OBA_2045170
Disease	pancreatic carcinoma	MYO1D SRGAP1 SBF2 APOB	3.38e-04	174	56	4	EFO_0002618
Disease	visual cortical surface area measurement	DCDC1 ALCAM	6.58e-04	20	56	2	EFO_0004771
Disease	nevus count, cutaneous melanoma	LRRC34 MKLN1 DCST2	6.99e-04	91	56	3	EFO_0000389, EFO_0004632
Disease	renal system measurement, blood urea nitrogen measurement	DCDC1 KBTBD8	7.98e-04	22	56	2	EFO_0004741, EFO_0004742
Disease	lipoprotein measurement	TTC39B APOB TASOR	1.06e-03	105	56	3	EFO_0004732
Disease	free cholesterol measurement, chylomicron measurement, very low density lipoprotein cholesterol measurement	MTTP APOB PMFBP1	1.21e-03	110	56	3	EFO_0008317, EFO_0008591, EFO_0008596
Disease	triglyceride measurement, intermediate density lipoprotein measurement	MTTP APOB PMFBP1	1.24e-03	111	56	3	EFO_0004530, EFO_0008595
Disease	cholesteryl esters to total lipids in large LDL percentage	TTC39B APOB	1.59e-03	31	56	2	EFO_0022249
Disease	sleep duration, high density lipoprotein cholesterol measurement	TTC39B APOB ALCAM	1.59e-03	121	56	3	EFO_0004612, EFO_0005271
Disease	carotid artery intima media thickness	THSD4 TLR3 APOB METTL4 ERMN	1.63e-03	450	56	5	EFO_0007117
Disease	triglyceride measurement, high density lipoprotein cholesterol measurement	TTC39B MTTP APOB PMFBP1	1.83e-03	274	56	4	EFO_0004530, EFO_0004612
Disease	choline measurement	TTC39B PLB1 APOB	1.95e-03	130	56	3	EFO_0010116
Disease	triacylglycerol 52:4 measurement	APOB TASOR	2.14e-03	36	56	2	EFO_0010416
Disease	very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	TTC39B APOB TASOR PMFBP1	2.27e-03	291	56	4	EFO_0008317, EFO_0020946

Protein segments in the cluster

Peptide	Gene	Start	Entry
NERYLNKLLSSGSRY	ARHGEF10	626	O15013
LAALEKTYNTYRSNT	B4GALNT2	531	Q8NHY0
ISNRSEYLKYSSSLA	ADAD1	221	Q96M93
LKTQVSYYAERLSRA	INPP4A	421	Q96PE3
LARNQYYRKSSVSSV	PPDPFL	11	Q8WWR9
ALLTYRLSKNEYFSL	PCDHA11	166	Q9Y5I1
LSSLRELYLQNNYLT	PODN	261	Q7Z5L7
AEKTLSYYQARLLSL	DCDC1	1376	M0R2J8
KRSRTSYTRYQTLEL	HOXC5	156	Q00444
YLNSSLRYLDVSCNK	LRRC34	291	Q8IZ02
RFTISRDNSKNSLYL	IGHV3-43D	86	P0DP04
SLQIRQYAYLSDRSS	ZBTB33	591	Q86T24
ERRAATLYSQYTSKN	SBF2	1726	Q86WG5
LYRLEKLSSSRYQDQ	GP6	56	Q9HCN6
LSLNNDRLYKLTYST	MTTP	26	P55157
KKSDISRNAYSRYNT	ERMN	246	Q8TAM6
NLLYVFSKRSNYITR	HUWE1	136	Q7Z6Z7
RFTISRDNSKNSLYL	IGHV3-43	86	A0A0B4J1X8
RTSRKNSLYQYDDIA	KBTBD8	551	Q8NFY9
GSNKYINYRDSKLTR	KIF19	291	Q2TAC6
NLYDLYTRTTNLSSK	EXOC5	306	O00471
RKFSRNYQLYKSVSL	APOB	631	P04114
DTTSLLKLQRYNSYD	DENND5B	166	Q6ZUT9
LKLQRYNSYDISRDT	DENND5B	171	Q6ZUT9
SYLYNVLLSRRTNLL	DCST2	541	Q5T1A1
AYYTLRAQALDRLTN	CDH7	116	Q9ULB5
LSQLVARRQKSSYNY	GPR139	51	Q6DWJ6
ARRQKSSYNYLLALA	GPR139	56	Q6DWJ6
YSIYNTKSSRERAAL	RYR2	3181	Q92736
YKDRLNLSENYTLSI	ALCAM	86	Q13740
QNKSVKRSNRYSYLS	METTL4	291	Q8N3J2
RLLFRSNISSKAQYY	CEBPZ	426	Q03701
SRQSETYNYLLAKKL	PHAX	146	Q9H814
TYRRRLSYNTASNKT	RPL34	6	P49207
RSLNLYRDKYQSSLS	PMFBP1	176	Q8TBY8
YRDKYQSSLSNIELL	PMFBP1	181	Q8TBY8
SLNRALRTYLSAEYN	SRGAP1	276	Q7Z6B7
YLLEYSRRKRSKSQN	SLC18B1	426	Q6NT16
YTLGRYLDSSVRNSK	MKLN1	341	Q9UL63
ESYRKFLNLRSSLSN	SHCBP1	256	Q8NEM2
LFSYRNSNYLTRLQK	PLB1	341	Q6P1J6
SRYSRYTSILDLDNK	SMCR8	801	Q8TEV9
KNANRITSLLAYRAY	TASOR	281	Q9UK61
RRDIAYNLSLIYQSS	GTF3C3	856	Q9Y5Q9
NSRLESILSKAYVYR	CNGB1	776	Q14028
SQLSTALSLLYRARY	CLUH	1076	O75153
YSGRLLSRANTEKSY	SETDB2	396	Q96T68
IYLSYNKYLQLTRNS	TLR3	461	O15455
TARNNYKDYSLESRL	TTC39B	651	Q5VTQ0
TNYRLYLRSLETDSS	MTM1	66	Q13496
RNYLSSIGKLSEYRN	REV3L	1391	O60673
NLAVALNRSYTKAYS	RPAP3	191	Q9H6T3
LYYRRSVELNSNSLE	TTC14	231	Q96N46
RALATSRYEKLQATY	SPTA1	356	P02549
KSNSDLLNYNRSYAR	ZNF630	186	Q2M218
AIYYLNSVSKSLSRA	TMC2	771	Q8TDI7
YKSNNYLALRSRSGR	THSD4	446	Q6ZMP0
YTYNNLSVESRSRTK	SLC9A7	396	Q96T83
SQYSLTRAQQSYKSL	UBE2Q1	391	Q7Z7E8
LKSYLGLTNQSRRYN	ZNF649	111	Q9BS31
LRSLHLQKSLSSYNY	MYO1D	216	O94832
TVDYDRTRNLKNLYS	NEB	4686	P20929
RTRNLKNLYSSNLYK	NEB	4691	P20929
AYKLQSSNLYKTSLR	NEB	4941	P20929