Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein phosphatase binding	JAK3 GRIN3A RACK1 PSG6 STAT1	5.28e-05	210	39	5	GO:0019903
GeneOntologyMolecularFunction	phosphatase binding	JAK3 GRIN3A RACK1 PSG6 STAT1	1.55e-04	264	39	5	GO:0019902
GeneOntologyBiologicalProcess	negative regulation of smoothened signaling pathway	RUNX2 RACK1 GAS1	6.82e-05	42	39	3	GO:0045879
GeneOntologyBiologicalProcess	interleukin-9-mediated signaling pathway	JAK3 STAT1	7.27e-05	7	39	2	GO:0038113
GeneOntologyBiologicalProcess	cellular response to interleukin-9	JAK3 STAT1	7.27e-05	7	39	2	GO:0071355
GeneOntologyBiologicalProcess	embryonic organ development	PKDCC STRC RUNX2 SH2B3 STRCP1 GAS1 ERVFRD-1	7.66e-05	561	39	7	GO:0048568
GeneOntologyBiologicalProcess	response to interleukin-9	JAK3 STAT1	9.68e-05	8	39	2	GO:0071104
GeneOntologyBiologicalProcess	regulation of Golgi to plasma membrane protein transport	PKDCC RACK1	1.90e-04	11	39	2	GO:0042996
GeneOntologyCellularComponent	phagocytic cup	RACK1 PEAR1 ADGRB1	3.03e-05	31	41	3	GO:0001891
GeneOntologyCellularComponent	vesicle coat	SEC31A BTBD8 SEC31B	3.07e-04	67	41	3	GO:0030120
GeneOntologyCellularComponent	kinocilium	STRC STRCP1	3.36e-04	14	41	2	GO:0060091
GeneOntologyCellularComponent	9+2 non-motile cilium	STRC STRCP1	3.36e-04	14	41	2	GO:0097732
GeneOntologyCellularComponent	COPII vesicle coat	SEC31A SEC31B	4.43e-04	16	41	2	GO:0030127
GeneOntologyCellularComponent	coated vesicle membrane	RNASEK SEC31A BTBD8 SEC31B	8.18e-04	215	41	4	GO:0030662
GeneOntologyCellularComponent	stereocilium tip	STRC STRCP1	8.46e-04	22	41	2	GO:0032426
GeneOntologyCellularComponent	membrane coat	SEC31A BTBD8 SEC31B	1.17e-03	106	41	3	GO:0030117
GeneOntologyCellularComponent	coated membrane	SEC31A BTBD8 SEC31B	1.17e-03	106	41	3	GO:0048475
GeneOntologyCellularComponent	endoplasmic reticulum exit site	SEC31A SEC31B	3.07e-03	42	41	2	GO:0070971
Domain	SH2	JAK3 SH2B3 STAT1	1.56e-03	110	39	3	SM00252
Domain	SH2	JAK3 SH2B3 STAT1	1.60e-03	111	39	3	PS50001
Domain	SH2	JAK3 SH2B3 STAT1	1.64e-03	112	39	3	IPR000980
Domain	-	JAK3 SH2B3 STAT1	1.64e-03	112	39	3	3.30.505.10
Domain	WD40	GEMIN5 SEC31A RACK1 SEC31B	2.03e-03	259	39	4	PF00400
Domain	WD40	GEMIN5 SEC31A RACK1 SEC31B	2.30e-03	268	39	4	SM00320
Domain	WD40_repeat	GEMIN5 SEC31A RACK1 SEC31B	2.42e-03	272	39	4	IPR001680
Domain	WD_REPEATS_1	GEMIN5 SEC31A RACK1 SEC31B	2.62e-03	278	39	4	PS00678
Domain	WD_REPEATS_2	GEMIN5 SEC31A RACK1 SEC31B	2.66e-03	279	39	4	PS50082
Domain	WD_REPEATS_REGION	GEMIN5 SEC31A RACK1 SEC31B	2.66e-03	279	39	4	PS50294
Domain	WD40_repeat_dom	GEMIN5 SEC31A RACK1 SEC31B	3.33e-03	297	39	4	IPR017986
Domain	WD40_repeat_CS	GEMIN5 RACK1 SEC31B	4.82e-03	164	39	3	IPR019775
Domain	-	GEMIN5 SEC31A RACK1 SEC31B	4.99e-03	333	39	4	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	GEMIN5 SEC31A RACK1 SEC31B	5.10e-03	335	39	4	IPR015943
Domain	p53-like_TF_DNA-bd	RUNX2 STAT1	5.47e-03	53	39	2	IPR008967
Domain	G-protein_beta_WD-40_rep	GEMIN5 RACK1	1.36e-02	85	39	2	IPR020472
Pathway	REACTOME_INTERLEUKIN_9_SIGNALING	JAK3 STAT1	1.36e-04	9	28	2	M27861
Pathway	BIOCARTA_IL22BP_PATHWAY	JAK3 STAT1	1.36e-04	9	28	2	MM1419
Pathway	BIOCARTA_IL22BP_PATHWAY	JAK3 STAT1	1.36e-04	9	28	2	M8066
Pathway	REACTOME_INTERLEUKIN_21_SIGNALING	JAK3 STAT1	1.70e-04	10	28	2	M27898
Pathway	KEGG_MEDICUS_REFERENCE_COPII_VESICLE_FORMATION	SEC31A SEC31B	2.48e-04	12	28	2	M47770
Pathway	WP_IL9_SIGNALING	JAK3 STAT1	5.08e-04	17	28	2	M39644
Pathway	WP_IL2_SIGNALING_PATHWAY	JAK3 RACK1 STAT1	6.65e-04	87	28	3	MM15915
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	1.36e-06	2	41	2	11687802
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	1.36e-06	2	41	2	34910522
Pubmed	The interferon-inducible protein p205 acts as an activator in osteoblast differentiation of mouse BMSCs.	RUNX2 RACK1	1.36e-06	2	41	2	26965419
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	4.06e-06	3	41	2	30801007
Pubmed	Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation.	RUNX2 STAT1	4.06e-06	3	41	2	12923053
Pubmed	Mammalian homologues of yeast sec31p. An ubiquitously expressed form is localized to endoplasmic reticulum (ER) exit sites and is essential for ER-Golgi transport.	SEC31A SEC31B	4.06e-06	3	41	2	10788476
Pubmed	Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550).	JAK3 STAT1	4.06e-06	3	41	2	21383241
Pubmed	Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.	STRC STRCP1	8.12e-06	4	41	2	18849963
Pubmed	Regulation of the Jak/STAT signalling pathway.	JAK3 STAT1	8.12e-06	4	41	2	8593242
Pubmed	The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor.	RACK1 STAT1	8.12e-06	4	41	2	11301323
Pubmed	Enhanced expression of Janus kinase-signal transducer and activator of transcription pathway members in human diabetic nephropathy.	JAK3 STAT1	1.35e-05	5	41	2	19017763
Pubmed	An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.	STRC STRCP1	1.35e-05	5	41	2	24920589
Pubmed	The JAK/STAT pathway is not sufficient to sustain the antiproliferative response in an interferon-resistant human melanoma cell line.	JAK3 STAT1	2.03e-05	6	41	2	12777975
Pubmed	JAK/STAT signaling by cytokine receptors.	JAK3 STAT1	2.84e-05	7	41	2	9638363
Pubmed	The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs).	JAK3 STAT1	2.84e-05	7	41	2	9342212
Pubmed	JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway.	JAK3 STAT1	3.78e-05	8	41	2	19414010
Pubmed	Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.	STRC STRCP1	3.78e-05	8	41	2	21165971
Pubmed	The Jak-STAT pathway.	JAK3 STAT1	4.86e-05	9	41	2	10781830
Pubmed	The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway.	JAK3 STAT1	4.86e-05	9	41	2	10506573
Pubmed	The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses.	JAK3 STAT1	4.86e-05	9	41	2	23435120
Pubmed	The hedgehog target Vlk genetically interacts with Gli3 to regulate chondrocyte differentiation during mouse long bone development.	PKDCC RUNX2	4.86e-05	9	41	2	23792766
Pubmed	The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways.	JAK3 STAT1	4.86e-05	9	41	2	17938255
Pubmed	The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex.	RACK1 STAT1	6.07e-05	10	41	2	12960323
Pubmed	Cytokines, Jaks, Stats, health and disease.	JAK3 STAT1	6.07e-05	10	41	2	10200816
Pubmed	Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.	STRC STRCP1	7.41e-05	11	41	2	31448880
Pubmed	Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.	STRC STRCP1	7.41e-05	11	41	2	31776257
Pubmed	The HIV matrix protein p17 subverts nuclear receptors expression and induces a STAT1-dependent proinflammatory phenotype in monocytes.	RACK1 STAT1	8.88e-05	12	41	2	22558273
Pubmed	Autophagy genes in myeloid cells counteract IFNγ-induced TNF-mediated cell death and fatal TNF-induced shock.	RB1CC1 STAT1	1.22e-04	14	41	2	31346084
Pubmed	The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome.	SEC31A SEC31B	1.61e-04	16	41	2	22792322
Pubmed	A quantitative protein interaction network for the ErbB receptors using protein microarrays.	JAK3 SH2B3 STAT1	1.66e-04	90	41	3	16273093
Pubmed	Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.	STRC STRCP1	1.82e-04	17	41	2	20856818
Pubmed	A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL Sustaining the Erythropoiesis.	JAK3 STAT1	2.29e-04	19	41	2	34360789
Pubmed	Decidualisation and placentation defects are a major cause of age-related reproductive decline.	GAS1 ERVFRD-1	4.00e-04	25	41	2	28874785
Pubmed	Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform.	KIR3DL2 GAS1	4.33e-04	26	41	2	36178190
Pubmed	BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation.	RUNX2 STAT1	5.03e-04	28	41	2	19224984
Pubmed	Temporospatial regulation of intraflagellar transport is required for the endochondral ossification in mice.	RUNX2 STAT1	5.39e-04	29	41	2	34929174
Pubmed	Molecular profiling of the vestibular lamina highlights a key role for Hedgehog signalling.	RUNX2 GAS1	6.17e-04	31	41	2	36971701
Pubmed	Axon guidance genes control hepatic artery development.	RGMA PSG6	8.33e-04	36	41	2	37497580
Pubmed	Genome-scale RNAi screen for host factors required for HIV replication.	SIK1 UBALD2 GTF2H1 RB1CC1	8.54e-04	361	41	4	18976975
Pubmed	FGF signalling regulates bone growth through autophagy.	SEC31A SEC31B	9.28e-04	38	41	2	26595272
Pubmed	A methylation-phosphorylation switch controls EZH2 stability and hematopoiesis.	STRC STRCP1	9.28e-04	38	41	2	38346162
Cytoband	15q15.3	STRC STRCP1	2.30e-04	25	41	2	15q15.3
GeneFamily	WD repeat domain containing	GEMIN5 SEC31A RACK1 SEC31B	3.07e-04	262	23	4	362
GeneFamily	SH2 domain containing	SH2B3 STAT1	7.24e-03	101	23	2	741
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	JAK3 GRIN3A SH2B3 PEAR1	1.55e-05	164	41	4	b6df1e67a5ce5f2d86f4e1420f4ee931f760bf4d
ToppCell	facs-Heart-LV-18m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RGMA RUNX2 BTN1A1 GAS1	1.75e-05	169	41	4	849a8f8509c58d65462a09c84d58b6ecdc8934f5
ToppCell	facs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RGMA RUNX2 BTN1A1 GAS1	2.05e-05	176	41	4	f25251abd4ef9fb077a978f9f9f658af58e4e0d2
ToppCell	facs-Heart-LV-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RGMA RUNX2 BTN1A1 GAS1	2.05e-05	176	41	4	fee4e0f32aaf77294040c7af6c1f503571750d43
Disease	central nervous system disease (implicated_via_orthology)	GEMIN5 SEC31A SEC31B	1.00e-06	16	37	3	DOID:331 (implicated_via_orthology)
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	1.53e-06	2	37	2	DOID:0110471 (implicated_via_orthology)
Disease	Juvenile Myelomonocytic Leukemia	JAK3 SH2B3	2.58e-04	19	37	2	C0349639
Disease	corpus callosum central volume measurement	GMNC PIGO	5.67e-04	28	37	2	EFO_0010296
Disease	overall survival, pancreatic carcinoma	GTF2H1 RUNX2	1.73e-03	49	37	2	EFO_0000638, EFO_0002618
Disease	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	JAK3 STAT1	2.03e-03	53	37	2	C1961099
Disease	Precursor Cell Lymphoblastic Leukemia Lymphoma	JAK3 SH2B3	2.67e-03	61	37	2	C1961102

Protein segments in the cluster

Peptide	Gene	Start	Entry
TFSGPLRPFFCLWSS	BTN1A1	451	Q13410
SAAAVFPANASRCSW	ADGRB1	56	O14514
FPANASRCSWTLRNP	ADGRB1	61	O14514
PPTDPSSRCNFFLWS	APEX2	501	Q9UBZ4
FSPNRYWLCAATGPS	RACK1	241	P63244
FALATEDLSCWFPPS	JAK3	71	P52333
LCWAPSPQDRPSFSA	JAK3	1076	P52333
SFRALPCVWSNSSDP	KIR3DL2	296	P43630
LFRGLDSWPPSFCTQ	RB1CC1	551	Q8TDY2
WDPTPFSVHSCFFNF	CELF2-AS1	161	Q8N7Q2
CSQDFFTLAPGTPLW	FAM124A	146	Q86V42
LNPSDPNTCSFWESF	PEAR1	21	Q5VY43
PTAFSVQDPWFCEAR	KNOP1	161	Q1ED39
AFPASAASFSSRWRC	GAS1	91	P54826
LRRSSSPAAWSCFQP	PCDHGB5	711	Q9Y5G0
SPWSSDPFSFLQSVC	GRIN3A	171	Q8TCU5
TTWIFSFPFCGPNRV	OR10A4	161	Q9H209
FARFWSERSFANIPP	BTBD8	346	Q5XKL5
APSFNFLSNSCWSKP	FBXO30	386	Q8TB52
FPFRPSDLIVCAWTA	PHYH	181	O14832
TPCQQNFFWDPSTSR	RUNX2	11	Q13950
AWAPVEPSFSARFSC	PUS3	176	Q9BZE2
FFLTPPCARWAQLSE	STAT1	486	P42224
FPARNFTLPCSAQGW	PKDCC	316	Q504Y2
SFSDSNFPLPDLCSW	GMNC	61	A6NCL1
LSCFADSNPPAEYSW	PSG6	351	Q00889
PQTFRPWSLNSNCRS	SPATA32	121	Q96LK8
SSLQWPLFFPVDASC	SIK1B	411	A0A0B4J2F2
SSLQWPLFFPVDASC	SIK1	411	P57059
WCPRDPSVFSAASFN	SEC31B	311	Q9NQW1
WPTLAFLLCSFPAAT	RGMA	31	Q96B86
SSLPDNCSFWDAFRP	STRC	651	Q7RTU9
AFFNWATSRALCSPP	CHST5	141	Q9GZS9
LLRHFWSCFPVNTPF	GTF2H1	471	P32780
RPSSCSTRNFWFRPA	ERVFRD-1	196	P60508
PCSFREEPQWSFAFE	TBC1D8B	1066	Q0IIM8
CLSLEWASAPNFRPT	SLC12A9	436	Q9BXP2
YEFWWSLSRPCPNSS	GEMIN5	1286	Q8TEQ6
SCNTVLFPFSLPHWD	SH2B3	471	Q9UQQ2
AACSPPANFSPFWAS	UBALD2	101	Q8IYN6
LLASQWAISPGFPFC	PIGO	466	Q8TEQ8
SSLPDNCSFWDAFRP	STRCP1	651	A6NGW2
LCPPARASWAFSHRF	RNASEK	11	Q6P5S7
WCPRNPAVLSAASFD	SEC31A	311	O94979