Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	MKRN3 MKRN4P RNF4 RNF31 MKRN1 RNF139 ZZEF1 RNF115 TRIM5	7.91e-06	398	68	9	GO:0061659
GeneOntologyMolecularFunction	ubiquitin protein ligase activity	MKRN3 MKRN4P RNF4 RNF31 MKRN1 RNF139 RNF115 TRIM5	3.75e-05	372	68	8	GO:0061630
GeneOntologyMolecularFunction	acyltransferase activity	MKRN3 MKRN4P RNF4 RNF31 MKRN1 KAT6B RNF139 ZZEF1 CREBBP RNF115 TRIM5	5.70e-05	775	68	11	GO:0016746
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	MKRN3 MKRN4P RNF4 RNF31 MKRN1 RNF139 ZZEF1 RNF115 TRIM5	5.74e-05	512	68	9	GO:0019787
GeneOntologyMolecularFunction	aminoacyltransferase activity	MKRN3 MKRN4P RNF4 RNF31 MKRN1 RNF139 ZZEF1 RNF115 TRIM5	7.70e-05	532	68	9	GO:0016755
GeneOntologyMolecularFunction	transition metal ion binding	TRAF4 RNF4 RNF31 EGLN1 POLR2K GATA4 ALB CHURC1 RNF139 ZZEF1 CREBBP TRIM5 GALNT4	1.62e-04	1189	68	13	GO:0046914
GeneOntologyMolecularFunction	zinc ion binding	TRAF4 RNF4 RNF31 POLR2K GATA4 ALB CHURC1 RNF139 ZZEF1 CREBBP TRIM5	1.96e-04	891	68	11	GO:0008270
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	MKRN3 MKRN4P RNF4 RNF31 MKRN1 RNF139 RNF115 TRIM5	1.99e-04	473	68	8	GO:0004842
GeneOntologyMolecularFunction	SMAD binding	FLNA GATA4 CREBBP COL1A2	2.12e-04	86	68	4	GO:0046332
GeneOntologyMolecularFunction	chromatin binding	MKRN4P MSH6 RNF4 MTF2 MKRN1 GATA4 KAT6B RPA1 CREBBP	8.67e-04	739	68	9	GO:0003682
GeneOntologyMolecularFunction	histone H3 acetyltransferase activity	KAT6B CREBBP	1.17e-03	15	68	2	GO:0010484
GeneOntologyBiologicalProcess	protein polyubiquitination	MKRN3 MKRN4P RNF4 RNF31 KBTBD6 MKRN1 RNF115 KBTBD7 TRIM5	3.38e-07	289	66	9	GO:0000209
GeneOntologyBiologicalProcess	embryonic heart tube anterior/posterior pattern specification	BMP2 GATA4	3.02e-05	3	66	2	GO:0035054
GeneOntologyBiologicalProcess	protein ubiquitination	MKRN3 MKRN4P RNF4 RNF31 KBTBD6 MKRN1 RNF139 ZZEF1 RNF115 KBTBD7 TRIM5	4.83e-05	811	66	11	GO:0016567
Domain	ZF_RING_1	MKRN3 MKRN4P TRAF4 RNF4 RNF31 CGRRF1 MKRN1 RNF139 RNF115 TRIM5	9.47e-08	291	68	10	PS00518
Domain	ZF_RING_2	MKRN3 MKRN4P TRAF4 RNF4 RNF31 CGRRF1 MKRN1 RNF139 RNF115 TRIM5	1.18e-07	298	68	10	PS50089
Domain	RING	MKRN3 MKRN4P TRAF4 RNF4 RNF31 CGRRF1 MKRN1 RNF139 RNF115 TRIM5	1.47e-07	305	68	10	SM00184
Domain	Znf_RING	MKRN3 MKRN4P TRAF4 RNF4 RNF31 CGRRF1 MKRN1 RNF139 RNF115 TRIM5	2.71e-07	326	68	10	IPR001841
Domain	zf-C3HC4	MKRN3 MKRN4P TRAF4 RNF4 MKRN1 RNF139 RNF115 TRIM5	1.45e-06	223	68	8	PF00097
Domain	Znf_C3HC4_RING-type	MKRN3 TRAF4 RNF4 MKRN1 RNF139 RNF115 TRIM5	3.00e-06	172	68	7	IPR018957
Domain	-	MKRN3 TRAF4 RNF4 MTF2 CGRRF1 MKRN1 KAT6B RNF139 RNF115 TRIM5	4.88e-06	449	68	10	3.30.40.10
Domain	Znf_RING/FYVE/PHD	MKRN3 TRAF4 RNF4 MTF2 CGRRF1 MKRN1 KAT6B RNF139 RNF115 TRIM5	5.92e-06	459	68	10	IPR013083
Domain	MKRN1_C	MKRN3 MKRN1	1.31e-05	2	68	2	PF15815
Domain	MKRN1_C	MKRN3 MKRN1	1.31e-05	2	68	2	IPR031644
Domain	Znf_RING_CS	MKRN3 TRAF4 RNF4 RNF31 MKRN1 TRIM5	2.82e-05	163	68	6	IPR017907
Domain	Fumarylacetoacetase_C-rel	FAHD2B FAHD2A	7.80e-05	4	68	2	IPR011234
Domain	FAA_hydrolase	FAHD2B FAHD2A	7.80e-05	4	68	2	PF01557
Domain	-	FAHD2B FAHD2A	7.80e-05	4	68	2	3.90.850.10
Domain	DUF3398	DOCK11 DOCK6	1.94e-04	6	68	2	PF11878
Domain	DOCK_C/D_N	DOCK11 DOCK6	1.94e-04	6	68	2	IPR021816
Domain	Peptidase_M12B_N	ADAMTS12 ADAM7 ADAMTS14	3.84e-04	39	68	3	IPR002870
Domain	Pep_M12B_propep	ADAMTS12 ADAM7 ADAMTS14	3.84e-04	39	68	3	PF01562
Domain	DISINTEGRIN_1	ADAMTS12 ADAM7 ADAMTS14	4.14e-04	40	68	3	PS00427
Domain	Reprolysin	ADAMTS12 ADAM7 ADAMTS14	4.14e-04	40	68	3	PF01421
Domain	ADAM_MEPRO	ADAMTS12 ADAM7 ADAMTS14	4.14e-04	40	68	3	PS50215
Domain	DISINTEGRIN_2	ADAMTS12 ADAM7 ADAMTS14	4.14e-04	40	68	3	PS50214
Domain	Peptidase_M12B	ADAMTS12 ADAM7 ADAMTS14	4.14e-04	40	68	3	IPR001590
Domain	Disintegrin_dom	ADAMTS12 ADAM7 ADAMTS14	4.46e-04	41	68	3	IPR001762
Domain	DOCK_C	DOCK11 DOCK6	7.03e-04	11	68	2	IPR010703
Domain	DHR-1_domain	DOCK11 DOCK6	7.03e-04	11	68	2	IPR027007
Domain	DHR_2	DOCK11 DOCK6	7.03e-04	11	68	2	PS51651
Domain	DHR_1	DOCK11 DOCK6	7.03e-04	11	68	2	PS51650
Domain	DOCK-C2	DOCK11 DOCK6	7.03e-04	11	68	2	PF14429
Domain	DHR-2	DOCK11 DOCK6	7.03e-04	11	68	2	IPR027357
Domain	DHR-2	DOCK11 DOCK6	7.03e-04	11	68	2	PF06920
Domain	DOCK	DOCK11 DOCK6	7.03e-04	11	68	2	IPR026791
Domain	ZnF_C3H1	MKRN3 MKRN4P MKRN1	7.10e-04	48	68	3	SM00356
Domain	zf-CCCH	MKRN3 MKRN4P MKRN1	7.54e-04	49	68	3	PF00642
Domain	zf-RING_2	RNF4 RNF139 RNF115	8.98e-04	52	68	3	PF13639
Domain	Znf_CCCH	MKRN3 MKRN4P MKRN1	1.23e-03	58	68	3	IPR000571
Domain	ZZ	ZZEF1 CREBBP	1.92e-03	18	68	2	PF00569
Domain	ZF_ZZ_2	ZZEF1 CREBBP	1.92e-03	18	68	2	PS50135
Domain	ZF_ZZ_1	ZZEF1 CREBBP	1.92e-03	18	68	2	PS01357
Domain	PLAC	ADAMTS12 ADAMTS14	2.15e-03	19	68	2	PS50900
Domain	Znf_ZZ	ZZEF1 CREBBP	2.15e-03	19	68	2	IPR000433
Domain	PLAC	ADAMTS12 ADAMTS14	2.15e-03	19	68	2	IPR010909
Domain	ZnF_ZZ	ZZEF1 CREBBP	2.15e-03	19	68	2	SM00291
Domain	ADAM_spacer1	ADAMTS12 ADAMTS14	3.15e-03	23	68	2	IPR010294
Domain	ADAM_spacer1	ADAMTS12 ADAMTS14	3.15e-03	23	68	2	PF05986
Domain	MetalloPept_cat_dom	ADAMTS12 ADAM7 ADAMTS14	3.22e-03	81	68	3	IPR024079
Domain	-	ADAMTS12 ADAM7 ADAMTS14	3.22e-03	81	68	3	3.40.390.10
Domain	Peptidase_M12B_ADAM-TS	ADAMTS12 ADAMTS14	3.42e-03	24	68	2	IPR013273
Domain	ACR	ADAM7 ADAMTS14	4.32e-03	27	68	2	SM00608
Domain	ADAM_Cys-rich	ADAM7 ADAMTS14	4.32e-03	27	68	2	IPR006586
Pubmed	Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos.	BMP2 GATA4 COL1A2	9.28e-07	10	70	3	15162503
Pubmed	Deterministic and stochastic allele specific gene expression in single mouse blastomeres.	MKRN4P BMP2 MSH6 AGO3 MTF2 MKRN1 GATA4 KAT6B	2.23e-06	424	70	8	21731673
Pubmed	Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks.	MKRN3 TRAF4 RNF4 CGRRF1 TRIM5	2.36e-06	105	70	5	22493164
Pubmed	Differential expression of murine CGI-105 gene in 3T3-L1 cells by adrenocorticotropic hormones.	FAHD2B FAHD2A	3.99e-06	2	70	2	15774318
Pubmed	A novel mutation combining with rs66612022 in a Chinese pedigree suggests a new pathogenesis to osteogenesis imperfecta via whole genome sequencing.	HMMR COL1A2	3.99e-06	2	70	2	31853946
Pubmed	Interactions of the zinc-regulated factor (ZiRF1) with the mouse metallothionein Ia promoter.	MTF2 POLR2K	3.99e-06	2	70	2	9173905
Pubmed	Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation.	MKRN4P MKRN1	3.99e-06	2	70	2	30143610
Pubmed	An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene.	MKRN4P MKRN1	3.99e-06	2	70	2	12721631
Pubmed	GATA-4 binds to an upstream element of the human alpha2(I) collagen gene (COL1A2) and inhibits transcription in fibroblasts.	GATA4 COL1A2	3.99e-06	2	70	2	15982862
Pubmed	Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13).	KAT6B CREBBP	3.99e-06	2	70	2	11157802
Pubmed	Identification of Makorin 1 as a novel SEREX antigen of esophageal squamous cell carcinoma.	MKRN4P MKRN1	3.99e-06	2	70	2	19604354
Pubmed	The putatively functional Mkrn1-p1 pseudogene is neither expressed nor imprinted, nor does it regulate its source gene in trans.	MKRN4P MKRN1	3.99e-06	2	70	2	16882727
Pubmed	Origin and evolution of processed pseudogenes that stabilize functional Makorin1 mRNAs in mice, primates and other mammals.	MKRN4P MKRN1	3.99e-06	2	70	2	16415359
Pubmed	A genetic system for tissue-specific inhibition of cell proliferation.	ALB COL1A2	1.20e-05	3	70	2	31988189
Pubmed	Acceleration of gastric tumorigenesis through MKRN1-mediated posttranslational regulation of p14ARF.	MKRN4P MKRN1	1.20e-05	3	70	2	23104211
Pubmed	Effect of rhBMP-2 on the osteogenic potential of bone marrow stromal cells from an osteogenesis imperfecta mouse (oim).	BMP2 COL1A2	1.20e-05	3	70	2	9213002
Pubmed	TRAF4 Inhibits the Apoptosis and Promotes the Proliferation of Breast Cancer Cells by Inhibiting the Ubiquitination of Spindle Assembly-Associated Protein Eg5.	TRAF4 KIF11	1.20e-05	3	70	2	35692762
Pubmed	The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system.	MKRN4P MKRN1	1.20e-05	3	70	2	10843807
Pubmed	Suppression of PPARγ through MKRN1-mediated ubiquitination and degradation prevents adipocyte differentiation.	MKRN4P MKRN1	1.20e-05	3	70	2	24336050
Pubmed	A universal metabolite repair enzyme removes a strong inhibitor of the TCA cycle.	FAHD2B FAHD2A	1.20e-05	3	70	2	38287013
Pubmed	A cross-ethnicity investigation of genes previously implicated in primary angle closure glaucoma.	CALCRL MFRP	1.20e-05	3	70	2	22933837
Pubmed	The KBTBD6/7-DRD2 axis regulates pituitary adenoma sensitivity to dopamine agonist treatment.	KBTBD6 KBTBD7	1.20e-05	3	70	2	32572597
Pubmed	Development of heart valves requires Gata4 expression in endothelial-derived cells.	GATA4 ALB	2.39e-05	4	70	2	16914500
Pubmed	Bone morphogenetic protein-2 modulates Wnt and frizzled expression and enhances the canonical pathway of Wnt signaling in normal keratinocytes.	BMP2 MFRP	2.39e-05	4	70	2	16442268
Pubmed	RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair.	RNF4 RPA1	2.39e-05	4	70	2	22661229
Pubmed	Filamin associates with stress signalling kinases MKK7 and MKK4 and regulates JNK activation.	FLNA MAP2K4	2.39e-05	4	70	2	20156194
Pubmed	The role of MAP2 kinases and p38 kinase in acute murine liver injury models.	MAP2K4 ALB	2.39e-05	4	70	2	28661486
Pubmed	Phylogenetic conservation of the makorin-2 gene, encoding a multiple zinc-finger protein, antisense to the RAF1 proto-oncogene.	MKRN4P MKRN1	2.39e-05	4	70	2	11597136
Pubmed	A ubiquitin-based effector-to-inhibitor switch coordinates early brain, craniofacial, and skin development.	KBTBD6 MUC19 DNAH5 KBTBD7	2.95e-05	87	70	4	37495603
Pubmed	Acetylation of MLH1 by CBP increases cellular DNA mismatch repair activity.	MSH6 CREBBP	3.98e-05	5	70	2	37094360
Pubmed	Bone morphogenetic protein 2- and estradiol-17β-induced changes in ovarian transcriptome during primordial follicle formation†.	BMP2 GATA4	5.96e-05	6	70	2	35639639
Pubmed	Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells.	FLNA MAP2K4	5.96e-05	6	70	2	9006895
Pubmed	Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis.	MKRN4P MKRN1	5.96e-05	6	70	2	19536131
Pubmed	Regulation of Wnt/PCP signaling through p97/VCP-KBTBD7-mediated Vangl ubiquitination and endoplasmic reticulum-associated degradation.	KBTBD6 KBTBD7	8.33e-05	7	70	2	33990333
Pubmed	Regulation of skeletal progenitor differentiation by the BMP and retinoid signaling pathways.	BMP2 COL1A2	8.33e-05	7	70	2	10684250
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	MKRN4P RNF31 EGLN1 MKRN1 KAT6B RNF139 CREBBP RNF115	8.89e-05	709	70	8	22988430
Pubmed	TRIM6 promotes colorectal cancer cells proliferation and response to thiostrepton by TIS21/FoxM1.	FLNA ALB KIF11	9.10e-05	43	70	3	31992359
Pubmed	A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.	RNF4 CGRRF1 RNF139 RNF115	9.71e-05	118	70	4	19690564
Pubmed	Filamin B mutations cause chondrocyte defects in skeletal development.	FLNA COL1A2	1.11e-04	8	70	2	17510210
Pubmed	Identification of potential nuclear reprogramming and differentiation factors by a novel selection method for cloning chromatin-binding proteins.	MKRN4P MKRN1	1.11e-04	8	70	2	15522233
Pubmed	Protein profile of exosomes from trabecular meshwork cells.	FLNA ALB COL1A2	1.35e-04	49	70	3	21362503
Pubmed	Neutral Sphingomyelinase 2 (SMPD3) Deficiency in Mice Causes Chondrodysplasia with Unimpaired Skeletal Mineralization.	BMP2 COL1A2	1.42e-04	9	70	2	31199918
Pubmed	Epicardially derived fibroblasts preferentially contribute to the parietal leaflets of the atrioventricular valves in the murine heart.	FLNA COL1A2	1.78e-04	10	70	2	22546693
Pubmed	SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kappaB-induced anti-apoptosis.	MAP2K4 ALB	1.78e-04	10	70	2	12376107
Pubmed	VEGF stimulates intramembranous bone formation during craniofacial skeletal development.	BMP2 COL1A2	1.78e-04	10	70	2	26899202
Pubmed	The TRAF2-p62 axis promotes proliferation and survival of liver cancer by activating mTORC1 pathway.	TRAF4 RNF31	1.78e-04	10	70	2	37081115
Pubmed	Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation.	BMP2 COL1A2	1.78e-04	10	70	2	16109715
Pubmed	Functional proteomics mapping of a human signaling pathway.	FLNA TRAF4 PSAP RNF4 MTF2 ZZEF1 CREBBP	1.88e-04	591	70	7	15231748
Pubmed	The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle development.	BMP2 GATA4	2.17e-04	11	70	2	16412416
Pubmed	Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy.	CHODL GRM7	2.17e-04	11	70	2	20019802
Pubmed	OTUD4-mediated GSDME deubiquitination enhances radiosensitivity in nasopharyngeal carcinoma by inducing pyroptosis.	FLNA KIF11	2.17e-04	11	70	2	36411454
Pubmed	Targeting peroxisome proliferator-activated receptor γ proteasomal degradation by magnolol is a potential avenue for adipogenesis-mediated metabolic homeostasis.	TRAF4 MKRN1	2.17e-04	11	70	2	37203337
Pubmed	GATA4 loss in the septum transversum mesenchyme promotes liver fibrosis in mice.	GATA4 ALB	2.17e-04	11	70	2	24415412
Pubmed	Developmental basis for filamin-A-associated myxomatous mitral valve disease.	FLNA COL1A2	2.17e-04	11	70	2	22843703
Pubmed	CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.	KBTBD6 KBTBD7	2.17e-04	11	70	2	25684205
Pubmed	Formation of multiple hearts in mice following deletion of beta-catenin in the embryonic endoderm.	BMP2 GATA4	2.17e-04	11	70	2	12194849
Pubmed	Bimodal regulation of the PRC2 complex by USP7 underlies tumorigenesis.	FLNA MTF2	2.17e-04	11	70	2	33849069
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	MKRN4P MSH6 ZNF836 MTF2 ZNF569 MKRN1 GATA4 KAT6B	2.17e-04	808	70	8	20412781
Pubmed	Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.	MKRN3 RNF4 RNF139 TRIM5	2.38e-04	149	70	4	19549727
Pubmed	BMP2 expression in the endocardial lineage is required for AV endocardial cushion maturation and remodeling.	BMP2 COL1A2	2.60e-04	12	70	2	28790014
Pubmed	The genes of the lysosomal cysteine proteinases cathepsin B, H, L, and S map to different mouse chromosomes.	FLNA GATA4	2.60e-04	12	70	2	9096102
Pubmed	Correct dosage of Fog2 and Gata4 transcription factors is critical for fetal testis development in mice.	BMP2 GATA4	2.60e-04	12	70	2	17848526
Pubmed	RERE deficiency leads to decreased expression of GATA4 and the development of ventricular septal defects.	BMP2 GATA4	2.60e-04	12	70	2	30061196
Pubmed	A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer.	FLNA ALB RPA1 NDUFS1 KIF11	2.84e-04	286	70	5	32041737
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	ZNF836 ZNF571 ALB ZNF319 RPA1 COL1A2	2.99e-04	451	70	6	36168627
Pubmed	Noncovalent interactions with SUMO and ubiquitin orchestrate distinct functions of the SLX4 complex in genome maintenance.	RNF4 RPA1	3.07e-04	13	70	2	25533185
Pubmed	The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis.	GATA4 ALB	3.07e-04	13	70	2	15531365
Pubmed	A mouse knockout library for secreted and transmembrane proteins.	ADAMTS12 KLK11 CHODL SHISA2 ALB IL36G	3.32e-04	460	70	6	20562862
Pubmed	Identifying genes differentially expressed between PGCs and ES cells reveals a role for CREB-binding protein in germ cell survival.	BMP2 CREBBP	3.58e-04	14	70	2	17936260
Pubmed	Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis.	BMP2 COL1A2	3.58e-04	14	70	2	17194222
Pubmed	Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas.	GATA4 ALB	3.58e-04	14	70	2	14736744
Pubmed	Desert hedgehog-primary cilia cross talk shapes mitral valve tissue by organizing smooth muscle actin.	FLNA COL1A2	3.58e-04	14	70	2	32151560
Pubmed	Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development.	BMP2 GATA4	3.58e-04	14	70	2	19084512
Pubmed	Expression of the BMP receptor Alk3 in the second heart field is essential for development of the dorsal mesenchymal protrusion and atrioventricular septation.	BMP2 FLNA	3.58e-04	14	70	2	23584254
Pubmed	GATA4 as a novel regulator involved in the development of the neural crest and craniofacial skeleton via Barx1.	GATA4 COL1A2	3.58e-04	14	70	2	29523871
Pubmed	Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.	DOCK11 DOCK6	3.58e-04	14	70	2	12432077
Pubmed	NOX2 Is Critical to Endocardial to Mesenchymal Transition and Heart Development.	BMP2 GATA4	3.58e-04	14	70	2	32655758
Pubmed	The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A.	FLNA EGLN1	3.58e-04	14	70	2	26972007
Pubmed	Histone modifications defining active genes persist after transcriptional and mitotic inactivation.	ALB CREBBP	3.58e-04	14	70	2	15616580
Pubmed	Transcriptional ontogeny of the developing liver.	MKRN4P MKRN1	4.12e-04	15	70	2	22260730
Pubmed	Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve With Raphe Formation.	BMP2 COL1A2	4.12e-04	15	70	2	38018454
Pubmed	Human immunodeficiency virus type 1 (HIV-1) Vpr enhances expression from unintegrated HIV-1 DNA.	POLR2K CREBBP	4.71e-04	16	70	2	12634356
Pubmed	Alk3 mediated Bmp signaling controls the contribution of epicardially derived cells to the tissues of the atrioventricular junction.	BMP2 COL1A2	4.71e-04	16	70	2	25300579
Pubmed	HIV-1 Vpr binding to HIV-1 LTR C/EBP cis-acting elements and adjacent regions is sequence-specific.	POLR2K CREBBP	4.71e-04	16	70	2	12642036
Pubmed	Identification and characterization of proteins interacting with Traf4, an enigmatic p53 target.	TRAF4 KIF11	4.71e-04	16	70	2	16969126
Pubmed	Extracellular matrix proteins expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line.	EFEMP1 COL1A2	4.71e-04	16	70	2	24804215
Pubmed	Dynamic signaling network for the specification of embryonic pancreas and liver progenitors.	BMP2 ALB	4.71e-04	16	70	2	19556507
Pubmed	Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F.	FLNA ALB KIF11	4.75e-04	75	70	3	31527668
Pubmed	Next-generation sequencing to generate interactome datasets.	MKRN3 TRAF4 EFEMP1 CGRRF1 STAC3 PDCL TCEANC RNF115 KBTBD7	4.78e-04	1147	70	9	21516116
Pubmed	MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1.	FLNA ALB RPA1 NDUFS1	5.08e-04	182	70	4	30711629
Pubmed	The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability.	FLNA ALB RPA1 KIF11 COL1A2	5.30e-04	328	70	5	23398456
Pubmed	Identification of RanBP 9/10 as interacting partners for protein kinase C (PKC) gamma/delta and the D1 dopamine receptor: regulation of PKC-mediated receptor phosphorylation.	ARHGEF25 TRIM5	5.33e-04	17	70	2	20395553
Pubmed	A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease.	BMP2 GATA4	5.33e-04	17	70	2	11572777
Pubmed	Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator.	POLR2K CREBBP	5.33e-04	17	70	2	11547919
Pubmed	Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue.	FAHD2B FAHD2A ALB DNAH5 NDUFS1	5.53e-04	331	70	5	29199018
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	FLNA PDCL DNAH5 CREBBP COL1A2	5.60e-04	332	70	5	37433992
Pubmed	An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation.	BMP2 GATA4	5.98e-04	18	70	2	17350578
Pubmed	USP15 Enhances Re-epithelialization Through Deubiquitinating EIF4A1 During Cutaneous Wound Repair.	FLNA ALB	5.98e-04	18	70	2	32671073
Pubmed	TGFβ and BMP Dependent Cell Fate Changes Due to Loss of Filamin B Produces Disc Degeneration and Progressive Vertebral Fusions.	BMP2 COL1A2	5.98e-04	18	70	2	27019229
Pubmed	Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk.	MSH6 POLR2K RPA1	6.62e-04	84	70	3	19237606
Interaction	UBE2W interactions	MKRN3 RNF4 RNF31 MKRN1 RNF115 TRIM5	9.39e-07	96	69	6	int:UBE2W
Interaction	UBE2D4 interactions	MKRN3 RNF4 RNF31 MKRN1 RNF115 TRIM5	3.30e-06	119	69	6	int:UBE2D4
Interaction	UBE2D1 interactions	MKRN3 TRAF4 RNF4 RNF31 MKRN1 CREBBP RNF115 TRIM5	7.21e-06	294	69	8	int:UBE2D1
Interaction	GREM2 interactions	BMP2 KBTBD6 ZZEF1 KBTBD7	7.63e-06	37	69	4	int:GREM2
Cytoband	2p16	MSH6 EFEMP1	1.50e-04	12	70	2	2p16
GeneFamily	Ring finger proteins	MKRN3 MKRN4P TRAF4 RNF4 RNF31 CGRRF1 MKRN1 RNF139 RNF115 TRIM5	1.54e-08	275	58	10	58
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	KAT6B CREBBP	1.33e-03	17	58	2	486
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	ZZEF1 CREBBP	1.50e-03	18	58	2	91
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS12 ADAMTS14	1.67e-03	19	58	2	50
ToppCell	356C-Lymphocytic-ILC-ILC-3\|356C / Donor, Lineage, Cell class and subclass (all cells)	KLK11 NUGGC ZNF836 POLR2K KAT6B	4.45e-06	154	70	5	923f5eb8e9258105dbdbe57a5e7976ef60dae29b
ToppCell	15-Trachea-Epithelial-Secretory_progenitor\|Trachea / Age, Tissue, Lineage and Cell class	KLK11 BMP2 FLNA EFEMP1 PLD3	1.14e-05	187	70	5	be9fce9e74b2f170a2067f1b31d802912a578329
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	KLK11 EFEMP1 DOCK11 GATA4 GRM7	1.17e-05	188	70	5	9655a4c47b644a870017d349b99063e17dbae572
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BMP2 CGRRF1 ARHGEF25 RPA1 COL1A2	1.40e-05	195	70	5	b0d408f8bc1701a87596ed55efcd90749fee33e6
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BMP2 CGRRF1 ARHGEF25 RPA1 COL1A2	1.40e-05	195	70	5	a486a7acea0e91048cc48afa0dbd3926d30bc217
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CGRRF1 ADAMTS14 ARHGEF25 RPA1 COL1A2	1.40e-05	195	70	5	2414b158dc7bdec43a9671544bfb7ffc5f5168fd
ToppCell	droplet-Bladder-BLADDER-1m\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFEMP1 CHODL CALCRL ARHGEF25 COL1A2	1.47e-05	197	70	5	1e24150c5146c93914aaaa981bd17589e8ed7cf9
ToppCell	COVID_non-vent-Lymphocytic-Plasma_cell-IgG_Plasmablast\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	NUGGC CD27 HMMR KIF11 COL1A2	1.47e-05	197	70	5	b754fad4f3caae6de95df901fd96ea8697fe41b1
ToppCell	droplet-Bladder-BLADDER\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFEMP1 CHODL CALCRL ARHGEF25 COL1A2	1.47e-05	197	70	5	5ae84f796005fa7b75d10b6464770da6cd5c8f53
ToppCell	droplet-Bladder-BLADDER-1m-Epithelial-bladder_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFEMP1 CHODL CALCRL ARHGEF25 COL1A2	1.51e-05	198	70	5	8f202ed4692ea2c139ff05d4805c704ee4be095c
ToppCell	(05)_Ciliated-(2)_48hpi\|(05)_Ciliated / shred by cell type and Timepoint	SEMA6B HMMR ARHGEF25 GRM7	4.38e-05	124	70	4	fc8cce8c1809edafbc4e69e501dd4f016f5dfc0b
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-matrix_-_immature_3\|E16.5-samps / Age Group, Lineage, Cell class and subclass	SHISA2 HMMR KIF11 COL1A2	8.94e-05	149	70	4	651494e84be03dc7b061ebdfa91756a1c507b9b4
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 SHISA2 VCPKMT COL1A2	9.17e-05	150	70	4	7a9d6a7ff8000e9a061e1b586e4c258cc91a2a09
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 SHISA2 VCPKMT COL1A2	9.17e-05	150	70	4	e5b843cb2bc847f6cab4cbec0a2a6a72fac50fee
ToppCell	severe_influenza-CD8+_T_naive\|World / disease group, cell group and cell class (v2)	ZNF836 FAHD2B CD27 ZNF571	1.18e-04	160	70	4	a1181ef36b453eba53b04d836aa9f65a71354cdb
ToppCell	severe_influenza-CD8+_T_naive\|severe_influenza / disease group, cell group and cell class (v2)	ZNF836 FAHD2B CD27 ZNF571	1.21e-04	161	70	4	82196139cdbbd70a36957a87bc9ac6d02575da3f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 CD27 ARHGEF25 COL1A2	1.23e-04	162	70	4	bfaeff19bb56598fdc8c82be71d51787cf13928f
ToppCell	normal_Pleural_Fluid-Myeloid_cells-mo-Mac\|Myeloid_cells / Location, Cell class and cell subclass	HMMR ARHGEF25 IL36G KIF11	1.36e-04	166	70	4	d16af6570806ed2880bd0efb5298932fd2a89cf5
ToppCell	droplet-Heart-nan-18m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSH6 ALB ARHGEF25 COL1A2	1.36e-04	166	70	4	9adceb746e67e955fd8b3e0984f4eed44b64a270
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-4\|TCGA-Lung / Sample_Type by Project: Shred V9	ADAMTS12 SEMA6B ADAMTS14 COL1A2	1.42e-04	168	70	4	aefea14b8b1c1b6a05f827effd22ba15274fddc9
ToppCell	PND10-Immune-Immune_Myeloid-DC-cDC2-cDC2_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PSAP MKRN1 HMMR KIF11	1.42e-04	168	70	4	4c402a1613fcf0a6e4d9b9d5551812940e91ff32
ToppCell	droplet-Pancreas-Exocrine-18m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA EFEMP1 ALB DNAH5	1.52e-04	171	70	4	5447b78148f7bccb727e2fc108589b2af02a5d31
ToppCell	droplet-Lung-immune-endo-depleted-3m-Lymphocytic-Proliferating_NK\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MSH6 HMMR RPA1 KIF11	1.52e-04	171	70	4	1eebd7138c3b20ddc1104f21615f9df0e776bbe6
ToppCell	droplet-Kidney-nan-24m-Lymphocytic-lymphocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MKRN1 HMMR IL36G KIF11	1.52e-04	171	70	4	ff117bf1a0755aa7d7c3db29749a7b9b90cc0b2f
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MKRN3 FLNA SPHKAP COL1A2	1.52e-04	171	70	4	82de2885c8ce4fb7776da6a0207b3355c0910121
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MKRN3 FLNA SPHKAP COL1A2	1.52e-04	171	70	4	09e653973962fb884878089d281f0947f7a285f6
ToppCell	droplet-Pancreas-Exocrine-18m-Epithelial-pancreatic_ductal_cel\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA EFEMP1 ALB DNAH5	1.55e-04	172	70	4	a7eee0a30d2fe20c865a07b9004c6a821a72c0c4
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FLNA CD27 PDCL DOCK6	1.55e-04	172	70	4	eee45759284baa3ed77da6a5fbcc4f8f6c553106
ToppCell	droplet-Pancreas-Exocrine-18m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA EFEMP1 ALB DNAH5	1.55e-04	172	70	4	0a9fe2cd28203970295a1288078c66eadac1c9ed
ToppCell	11.5-Distal-Mesenchymal-Mesenchyme_SERPINF1-high\|Distal / Age, Tissue, Lineage and Cell class	KLK11 CHODL DOCK11 GATA4	1.59e-04	173	70	4	6989c9cebcd81eccceac7e5a86152676ee959386
ToppCell	droplet-Lung-LUNG-1m-Lymphocytic-Proliferating_NK\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRAF4 HMMR ADAMTS14 KIF11	1.59e-04	173	70	4	31784679190fbd95fc23d7c66008eb21b8c7cc5d
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Neuronal-Neuron\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	FAHD2B DOCK11 STAC3 RPA1	1.66e-04	175	70	4	2812ac2ef41d245db544697fb6da1883361c96e8
ToppCell	metastatic_Brain-Fibroblasts-Undetermined\|metastatic_Brain / Location, Cell class and cell subclass	ADAMTS12 EFEMP1 ARHGEF25 COL1A2	1.73e-04	177	70	4	54f39be5d90363cfd44dea1a96ae06d3143aa795
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6\|TCGA-Ovary / Sample_Type by Project: Shred V9	ADAMTS12 SHISA2 ADAMTS14 COL1A2	1.77e-04	178	70	4	142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCell	3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLNA PSAP STAC3 PLD3	1.77e-04	178	70	4	0b398656f26c4061b11ccf98908d0e2e1367585a
ToppCell	PND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EFEMP1 GATA4 HMMR PDZD4	1.77e-04	178	70	4	c77a1d1a9aef0ab51b4408b9e84f201219788ca2
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMMR ZNF319 TCEANC KIF11	1.81e-04	179	70	4	4166c4e1a8748a79ac6a11fd0b97c5344be2321b
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Epithelial-neuroepithelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHODL ALB KIF11 COL1A2	1.89e-04	181	70	4	c26d3cbbc592299786d79d1b15fc6bead2aafb9a
ToppCell	Pericytes-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	ADAMTS12 ADAMTS14 ARHGEF25 COL1A2	1.89e-04	181	70	4	35c470988a93381eefa300831aabb813fa1b90bd
ToppCell	Children_(3_yrs)-Epithelial-club_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	KLK11 TRAF4 SHC4 DNAH5	1.93e-04	182	70	4	215c303df42f13597b2c7a95cb157c6bc7aca9a1
ToppCell	PND01-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SEMA6B DOCK11 PLD3 KIF11	1.93e-04	182	70	4	57f8b8d7b132f3ad6f2b1e79c3812fe938657d2c
ToppCell	tumor_Lung-Fibroblasts-Mesothelial_cells\|tumor_Lung / Location, Cell class and cell subclass	KLK11 EFEMP1 GATA4 COL1A2	2.01e-04	184	70	4	b0a251030d127858e68cf164be158f209a4d720f
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS12 EFEMP1 CALCRL COL1A2	2.05e-04	185	70	4	3cd0686a14e734a0f243070ab939adcb4c454478
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS12 EFEMP1 CALCRL COL1A2	2.05e-04	185	70	4	00258f458cbf6d36449db95528a6b5038d731d2d
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Mesenchymal\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADAMTS12 EFEMP1 CALCRL COL1A2	2.05e-04	185	70	4	a94694e226856bc5b168464f52d76004145717a5
ToppCell	droplet-Liver-LIVER_HEP-30m-Mesenchymal\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFEMP1 SHC4 ARHGEF25 COL1A2	2.05e-04	185	70	4	f814ec9d4ade717a0109398e9768d0d66f09317b
ToppCell	droplet-Liver-LIVER_HEP-30m-Mesenchymal-hepatic_stellate_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFEMP1 SHC4 ARHGEF25 COL1A2	2.05e-04	185	70	4	40e958511790e84321da5ccf735f9974c06a0263
ToppCell	droplet-Liver-LIVER_HEP-30m-Mesenchymal-hepatic_stellate_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFEMP1 SHC4 ARHGEF25 COL1A2	2.05e-04	185	70	4	5f2eeba80aff145e85cfd81e2890a155406badb9
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	KLK11 EFEMP1 GATA4 GRM7	2.05e-04	185	70	4	492529121cb9e88bd3c0db6b54af3cd2979572bc
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_adventitial_fibro_(9)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	DOCK11 GATA4 GRM7 COL1A2	2.10e-04	186	70	4	8915436d09775f2828a7678af203b1082b36e21c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 HMMR KIF11 COL1A2	2.14e-04	187	70	4	e41e39fd3791acf8ae5376cc5061e196d96868ae
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTS12 HMMR KIF11 COL1A2	2.14e-04	187	70	4	cefa211ef224e803ea9467882e2ca74d0b1492f1
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	KLK11 DOCK11 GATA4 GRM7	2.14e-04	187	70	4	8e8f1f2a78ac5f13a414fd448af7d7ff1ea86f0f
ToppCell	Pericytes-HP_01\|World / lung cells shred on cell class, cell subclass, sample id	ADAMTS12 ARHGEF25 PDZD4 COL1A2	2.14e-04	187	70	4	35f25780d113f60bf4c13749013c09612ee4ff41
ToppCell	Control-B_intermediate-6\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	FLNA PSAP CD27 STAC3	2.23e-04	189	70	4	11cb9a16f1de8f60af2073ed7ea6d4f41c02f299
ToppCell	3'-Adult-LargeIntestine-Mesenchymal-myocytic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMTS12 FLNA ARHGEF25 COL1A2	2.23e-04	189	70	4	f7e2ee5047792ab9ef6472fa88e2d193cdea6fa0
ToppCell	facs-Skin-Anagen\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PSAP SHISA2 ALB PDZD4	2.23e-04	189	70	4	adbfc723130079b4caf551f66d2aee86fab1903c
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	DOCK11 GATA4 GRM7 COL1A2	2.32e-04	191	70	4	156b467187331ac6ca390d6ca861d9670bb7b956
ToppCell	human_hepatoblastoma-Hepatic_Stellate_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	ADAMTS12 EFEMP1 SHISA2 COL1A2	2.32e-04	191	70	4	78c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-lymphocytic-B_lymphocytic-plasma_cell\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NUGGC CD27 HMMR KIF11	2.32e-04	191	70	4	b23fdcd3090df9f58310b4dc8f7dc0c6d6b33226
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CGRRF1 ADAMTS14 ARHGEF25 COL1A2	2.36e-04	192	70	4	93903576dddd8227328e4ced75aa7625eedb9baf
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP2 AGO3 GATA4 CALCRL	2.36e-04	192	70	4	2bfac6b3956265205ca47d06888851ed68b65999
ToppCell	COVID-19_Severe-Plasmablast\|World / disease group, cell group and cell class	NUGGC CD27 HMMR KIF11	2.36e-04	192	70	4	a333053fe2bd206c32790916bfc5fce904ab7f57
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Subpleural_fibroblasts-Subpleural_fibroblasts_L.2.1.5.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EFEMP1 GATA4 ARHGEF25 COL1A2	2.36e-04	192	70	4	859a32c9e4ed6961897b2ccaecde73a599471df9
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Subpleural_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EFEMP1 GATA4 ARHGEF25 COL1A2	2.36e-04	192	70	4	89e1da82fa2069dac7adb9cba3e8b6c0179e0dc5
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EFEMP1 CHODL PLD3 COL1A2	2.36e-04	192	70	4	20ede290e01ad574afd122d72b59dbc52c595fad
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP2 AGO3 GATA4 CALCRL	2.36e-04	192	70	4	d525f7f088a53110912600a7c9f6d33b9270d534
ToppCell	COPD-Endothelial-Lymphatic\|World / Disease state, Lineage and Cell class	BMP2 EFEMP1 CALCRL DOCK6	2.41e-04	193	70	4	25bdc557055b5bce6a21f8696b48e991c696b979
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP2 GATA4 CALCRL DOCK6	2.41e-04	193	70	4	826b8dd801298b3e0cd76232feae5a14026b8806
ToppCell	COPD-Endothelial-Lymphatic\|COPD / Disease state, Lineage and Cell class	BMP2 EFEMP1 CALCRL DOCK6	2.41e-04	193	70	4	18bcf08068a236c4575c7a07181ac893dfdcbeeb
ToppCell	PBMC-Severe-Lymphocyte-B-Plasmablast\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	NUGGC CD27 HMMR KIF11	2.41e-04	193	70	4	227d82059a9f99937e0188ff57f2d0e485ebfe69
ToppCell	PBMC-Severe-Lymphocyte-B-Plasmablast-Plasmablast-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	NUGGC CD27 HMMR KIF11	2.41e-04	193	70	4	38bb14df7f05c29565a1c7f175fafe636e543bf8
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP2 GATA4 CALCRL DOCK6	2.41e-04	193	70	4	87d3a577d37fb0cb4b6313c596310de452bc3872
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CGRRF1 ADAMTS14 ARHGEF25 COL1A2	2.41e-04	193	70	4	cfab88935abe0a15632c5eec8ff00a857ec9b3ed
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP2 GATA4 CALCRL DOCK6	2.41e-04	193	70	4	d485634c564b268e344b6a2863c26f6adaec9e38
ToppCell	PBMC-Severe-Lymphocyte-B-Plasmablast-Plasmablast\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	NUGGC CD27 HMMR KIF11	2.41e-04	193	70	4	3ba6d44248690b80f4caf791d463e60f1ab816c4
ToppCell	BAL-Severe-Lymphocyte-B-Plasmablast-Plasmablast-Developping_Plasmablast\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NUGGC CD27 HMMR KIF11	2.41e-04	193	70	4	0373984547cefc0cbd77f8e795d508f6fcebc6c8
ToppCell	PBMC-Severe-Lymphocyte-B-Plasmablast\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NUGGC CD27 HMMR KIF11	2.41e-04	193	70	4	ce3873ece35fd2155ea235cb3c8bcd235cc0ebde
ToppCell	PBMC-Severe-Lymphocyte-B-Plasmablast-Plasmablast\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NUGGC CD27 HMMR KIF11	2.41e-04	193	70	4	8f57b0473a2c2c07f83e5fe70f16862b1bb3b514
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMP2 AGO3 GATA4 CALCRL	2.46e-04	194	70	4	c8b9551b93a5aed62154b487db90130604a6125c
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA ADAMTS14 ARHGEF25 COL1A2	2.46e-04	194	70	4	bf34737ae2dc218f890fbb9201c308b324415749
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA ADAMTS14 ARHGEF25 COL1A2	2.46e-04	194	70	4	b35e33439b6d3b5d69147e617224d2c8fd056223
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNA ADAMTS14 ARHGEF25 COL1A2	2.46e-04	194	70	4	4ebed7a6731b88c8359860072cbeba355a7e90ac
ToppCell	droplet-Bladder-BLADDER-1m-Epithelial-bladder_mesenchymal_cell_(Scara5+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFEMP1 CHODL ARHGEF25 COL1A2	2.51e-04	195	70	4	d663d54a4bcc94e2c9b50ed931e2b2db4ca41373
ToppCell	3'_v3-blood-Lymphocytic_NK-NK_CD56bright_CD16-\|blood / Manually curated celltypes from each tissue	BMP2 TRAF4 POLR2K RNF115	2.51e-04	195	70	4	1470f562ebcfe7da367964ecfd6c7f43bcdb4a73
ToppCell	COVID-19-lung-Proliferative_fibroblast\|lung / Disease (COVID-19 only), tissue and cell type	ADAMTS12 HMMR KIF11 COL1A2	2.56e-04	196	70	4	2ce8a787f2731faa913d20342d73041d59468f27
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia_independent-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FLNA EFEMP1 ADAMTS14 COL1A2	2.56e-04	196	70	4	b8b9801181d7604871b48aebacb295d0a57a5eaf
ToppCell	COVID-19-lung-Proliferative_fibroblast\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ADAMTS12 HMMR KIF11 COL1A2	2.56e-04	196	70	4	ca91d5e325875e7444809b80fcbd491d8899ea36
ToppCell	Lung_Parenchyma-Control-Lymphocyte-B-Plasmablast-Plasmablast-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	NUGGC CD27 HMMR KIF11	2.61e-04	197	70	4	0d38d126b1e653398426255e95449f1150eac1b0
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-E\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	EFEMP1 PSAP PLD3 COL1A2	2.61e-04	197	70	4	9b1c1d72c5a8c90d71ae31e4c198d2276872eaa0
ToppCell	Parenchyma_Control_(B.)-Immune-TX-Plasma_cells\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	NUGGC CD27 HMMR KIF11	2.61e-04	197	70	4	7ffb373d5b72c67e4816f14ea9a7a2024dc7a93a
ToppCell	Mild/Remission-B_intermediate-6\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	FLNA PSAP MKRN1 STAC3	2.61e-04	197	70	4	5370dda4a25e3a53d6fe2c887b7dabd7a58462b4
ToppCell	Lung_Parenchyma-Control-Lymphocyte-B-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	NUGGC CD27 HMMR KIF11	2.61e-04	197	70	4	2e76e9ebd8702bfeefd396cbf5114eee0f24c19b
ToppCell	facs-Heart\|facs / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PSAP GATA4 ARHGEF25 COL1A2	2.61e-04	197	70	4	6a9571c0a3238b39214afdece93d7541bc8a0a70
ToppCell	Severe-Plasmablast\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	NUGGC PSAP CD27 PLD3	2.61e-04	197	70	4	1089aa7991812378668d0f3d57f8000e6245a713
ToppCell	Lung_Parenchyma-Control-Lymphocyte-B-Plasmablast-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	NUGGC CD27 HMMR KIF11	2.61e-04	197	70	4	207fce47e547fafbaf64a22efe3488e74bf19bed
ToppCell	droplet-Bladder-BLADDER-1m-Epithelial-bladder_mesenchymal_cell_(Car3+)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFEMP1 CALCRL RPA1 COL1A2	2.61e-04	197	70	4	86145bc1e585b4ae136e755cafd6579da2abfa65
ToppCell	droplet-Bladder-BLADDER-1m-Epithelial\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EFEMP1 CHODL ARHGEF25 COL1A2	2.61e-04	197	70	4	036c4c9b3ae80e2dc21c24a84504d3da0541f945
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_monocytic-classical_monocyte\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SEMA6B FLNA PSAP PLD3	2.66e-04	198	70	4	74591eba5dbb2d77d416309326a26be969e4ad42
ToppCell	TCGA-Skin-Metastatic-Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	MSH6 DOCK11 CALCRL KAT6B	2.66e-04	198	70	4	af4fb9eb2295c7b90624b38ba25619aa15254efa
Disease	Malignant neoplasm of breast	BMP2 FLNA MSH6 MAP2K4 EFEMP1 ZNF569 HMMR KAT6B RNF115 THOC5 PDZD4	2.80e-05	1074	67	11	C0006142
Disease	Attention deficit hyperactivity disorder	GRM7 MED13	1.36e-03	24	67	2	C1263846
Disease	Breast Carcinoma	BMP2 FLNA MAP2K4 EFEMP1 HMMR RNF115	1.39e-03	538	67	6	C0678222
Disease	upper face morphology measurement	EFEMP1 GATA4 ALB	1.42e-03	97	67	3	EFO_0010949
Disease	plasma clusterin measurement	MTF2 GRM7	1.47e-03	25	67	2	EFO_0007656
Disease	osteoarthritis (is_implicated_in)	BMP2 ADAMTS14	1.85e-03	28	67	2	DOID:8398 (is_implicated_in)
Disease	body weight	EFEMP1 SPHKAP GATA4 PDCL ADAMTS14 KAT6B ZZEF1 RPA1 GRM7	2.12e-03	1261	67	9	EFO_0004338
Disease	osteoporosis (is_implicated_in)	BMP2 COL1A2	2.26e-03	31	67	2	DOID:11476 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
ETYGEMADCCAKQEP	ALB	106	P02768
QAVEVMCFVPKRCND	ARHGEF25	321	Q86VW2
QMCEPGTFLVKDCDQ	CD27	41	P26842
CNNGECLNMEKVYIS	ADAM7	616	Q9H2U9
EQEIDPVMQSLGYCC	CREBBP	1186	Q92793
CFCKYAQGADSVEPM	AGO3	491	Q9H9G7
VLKNYQDMVVEGCGC	BMP2	381	P12643
NVCINGICKMVGCDY	ADAMTS12	666	P58397
CLGPMFEYQVCNSEE	ADAMTS14	591	Q8WXS8
EVACYVCKILDQMPA	MAP2K4	376	P45985
CGICMEVVYEKANPN	MKRN4P	316	Q13434
PNEMVICDKCGQGYH	MTF2	116	Q9Y483
EVDGNMSKIYCQNLC	KAT6B	791	Q8WYB5
CEPVQVEMCLGLSYN	MFRP	466	Q9BY79
CCYEQRTMGKNPEIE	VCPKMT	171	Q9H867
QVKELGVVMYNCSCL	PLD3	226	Q8IV08
VCPILDEVIMGYNCT	KIF11	86	P52732
KSQCDCYINDEVMQP	MUC19	1131	Q7Z5P9
MGCNMCVVQKPEEQY	PDZD4	1	Q76G19
CENAYPGNITDTMVC	KLK11	206	Q9UBX7
VGMNYVDHCKEQNVP	FAHD2A	111	Q96GK7
FNDEIYCICDIPVMK	KBTBD7	521	Q8WVZ9
AVMAQMGCYVPAEVC	MSH6	1151	P52701
KEGNTNCYRAPMECQ	HMMR	706	O75330
LRKENCMYQACPTQD	RPA1	471	P27694
AEGEPVCNACGLYMK	GATA4	286	P43694
DPNQGCTMDAIKVYC	COL1A2	1181	P08123
NPEMCLYCEKVGEQP	IL36G	81	Q9NZH8
IYLDACIDVVQCPKM	DOCK11	221	Q5JSL3
LQQGDISECCEPYMV	DOCK6	346	Q96HP0
VGMNYVDHCKEQNVP	FAHD2B	111	Q6P2I3
KVKMDCQECPEGYRV	FLNA	2471	P21333
ELCAEVPEQKNYVGM	GALNT4	501	Q8N4A0
EYIVPCMNKHGICVV	EGLN1	196	Q9GZT9
NKDLCADYRGVCPEM	GRM7	426	Q14831
DGCVKYFQQCPMCRQ	CGRRF1	296	Q99675
KIMQDPIQQAEGVYC	CALCRL	51	Q16602
CLGKYVVVFNCSDQM	DNAH5	1996	Q8TE73
FNEEIYCICDIPVMK	KBTBD6	521	Q86V97
EAMNGCMICLAAEYP	PDCL	196	Q13371
CGICMEVVYEKANPS	MKRN1	281	Q9UHC7
CPLNYEVIMNTGVCV	OR14A2	126	Q96R54
TCPMCHQKVYIEDDI	RNF139	581	Q8WU17
QYQCVNEPGKFSCMC	EFEMP1	306	Q12805
MPCQIGFVEDKSENC	SPHKAP	66	Q2M3C7
IAQCFACMEQPLQEG	NUGGC	506	Q68CJ6
QVDMGLECPVCKEDY	RNF115	221	Q9Y4L5
VTCKAVLICDYGPME	SNHG12	31	Q9BXW3
QACEKVGMQIPRFCY	NDUFS1	51	P28331
CCLPEGTMNNVYVNM	SHISA2	206	Q6UWI4
CVCNMNIKGADVGVY	MED13	1096	Q9UHV7
MCGDCVEKEYPNRGN	CHURC1	1	Q8WUH1
EPSCGSEKCVVMYHQ	CHODL	136	Q9H9P2
AMYLQENGIDCPKCK	RNF31	861	Q96EP0
QATEQMAYCPIQCEK	SHC4	396	Q6S5L8
CAGFQPDAMCNIEKN	TRIM5	376	Q9C035
VPVARCQQYSGCMKN	SEMA6B	521	Q9H3T3
PDEQMMTYVICNECG	TCEANC	326	Q8N8B7
CGICMEVVYEKANPN	MKRN3	311	Q13064
SCPICMDGYSEIVQN	RNF4	131	P78317
KQQPMIYICGECHTE	POLR2K	11	P53803
HEGMCPQESVYCENK	TRAF4	156	Q9BUZ4
PQESVYCENKCGARM	TRAF4	161	Q9BUZ4
PKDNGDVCQDCIQMV	PSAP	191	P07602
QAEQKPFVCGVCKMG	ZNF319	126	Q9P2F9
KPYECNECGKAFIQM	ZNF569	436	Q5MCW4
CVGTRCVYMDNANEP	ZZEF1	2256	O43149
MEGEVNVCYKELCGP	THOC5	601	Q13769
CQSYVEMQRCFGKIP	STAC3	131	Q96MF2
QRIQTGEKPYECMEC	ZNF571	186	Q7Z3V5
GEMPYKCIECGQVFN	ZNF836	746	Q6ZNA1