Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	sphingosine N-acyltransferase activity	CERS2 CERS6 CERS3	1.79e-08	7	17	3	GO:0050291
GeneOntologyMolecularFunction	sphingomyelin synthase activity	SGMS2 SGMS1	2.05e-06	3	17	2	GO:0033188
GeneOntologyMolecularFunction	ceramide phosphoethanolamine synthase activity	SGMS2 SGMS1	2.05e-06	3	17	2	GO:0002950
GeneOntologyMolecularFunction	ceramide cholinephosphotransferase activity	SGMS2 SGMS1	2.05e-06	3	17	2	GO:0047493
GeneOntologyMolecularFunction	acyltransferase activity, transferring groups other than amino-acyl groups	CERS2 CERS6 SOAT1 CERS3	4.15e-05	238	17	4	GO:0016747
GeneOntologyMolecularFunction	N-acyltransferase activity	CERS2 CERS6 CERS3	8.35e-05	102	17	3	GO:0016410
GeneOntologyMolecularFunction	phosphotransferase activity, for other substituted phosphate groups	SGMS2 SGMS1	1.56e-04	22	17	2	GO:0016780
GeneOntologyMolecularFunction	acyltransferase activity	CERS2 CERS6 SOAT1 CERS3	3.58e-03	775	17	4	GO:0016746
GeneOntologyMolecularFunction	hexosyltransferase activity	ALG3 UGT2A1	1.36e-02	211	17	2	GO:0016758
GeneOntologyBiologicalProcess	ceramide biosynthetic process	CERS2 SGMS2 CERS6 CERS3 SGMS1	2.89e-09	73	17	5	GO:0046513
GeneOntologyBiologicalProcess	ceramide metabolic process	CERS2 SGMS2 CERS6 CERS3 SGMS1	2.65e-08	113	17	5	GO:0006672
GeneOntologyBiologicalProcess	sphingolipid biosynthetic process	CERS2 SGMS2 CERS6 CERS3 SGMS1	3.16e-08	117	17	5	GO:0030148
GeneOntologyBiologicalProcess	membrane lipid biosynthetic process	CERS2 SGMS2 CERS6 CERS3 SGMS1	1.38e-07	157	17	5	GO:0046467
GeneOntologyBiologicalProcess	amide biosynthetic process	CERS2 SGMS2 CERS6 CERS3 SGMS1	2.17e-07	172	17	5	GO:0043604
GeneOntologyBiologicalProcess	sphingolipid metabolic process	CERS2 SGMS2 CERS6 CERS3 SGMS1	2.43e-07	176	17	5	GO:0006665
GeneOntologyBiologicalProcess	membrane lipid metabolic process	CERS2 SGMS2 CERS6 CERS3 SGMS1	8.96e-07	229	17	5	GO:0006643
GeneOntologyBiologicalProcess	sphingomyelin biosynthetic process	SGMS2 SGMS1	3.50e-05	11	17	2	GO:0006686
GeneOntologyBiologicalProcess	amide metabolic process	CERS2 SGMS2 CERS6 CERS3 SGMS1	4.43e-05	511	17	5	GO:0043603
GeneOntologyBiologicalProcess	sphingomyelin metabolic process	SGMS2 SGMS1	1.33e-04	21	17	2	GO:0006684
GeneOntologyBiologicalProcess	lipid biosynthetic process	CERS2 SGMS2 CERS6 CERS3 SGMS1	3.91e-04	813	17	5	GO:0008610
GeneOntologyBiologicalProcess	negative regulation of blood pressure	SCPEP1 AGTR2	1.49e-03	70	17	2	GO:0045776
GeneOntologyBiologicalProcess	organic hydroxy compound metabolic process	ALG3 SOAT1 AGTR2 UGT2A1	1.59e-03	641	17	4	GO:1901615
GeneOntologyBiologicalProcess	membrane biogenesis	PEX16 REEP4	1.62e-03	73	17	2	GO:0044091
GeneOntologyCellularComponent	endoplasmic reticulum membrane	PEX16 CERS2 ATP13A1 SGMS2 ALG3 CERS6 SOAT1 CERS3 REEP4 SGMS1 UGT2A1	4.26e-10	1293	17	11	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	PEX16 CERS2 ATP13A1 SGMS2 ALG3 CERS6 SOAT1 CERS3 REEP4 SGMS1 UGT2A1	4.48e-10	1299	17	11	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	PEX16 CERS2 ATP13A1 SGMS2 ALG3 CERS6 SOAT1 CERS3 REEP4 SGMS1 UGT2A1	5.62e-10	1327	17	11	GO:0042175
MousePheno	abnormal ceramide level	SGMS2 CERS6 SGMS1	3.90e-06	32	14	3	MP:0012232
MousePheno	abnormal sphingolipid level	SGMS2 CERS6 SGMS1	7.73e-06	40	14	3	MP:0012230
MousePheno	abnormal sphingomyelin level	SGMS2 SGMS1	8.42e-05	14	14	2	MP:0009823
Domain	Lag1/Lac1	CERS2 CERS6 CERS3	1.03e-08	6	16	3	IPR016439
Domain	TLC	CERS2 CERS6 CERS3	2.87e-07	16	16	3	PS50922
Domain	TLC-dom	CERS2 CERS6 CERS3	2.87e-07	16	16	3	IPR006634
Domain	TRAM_LAG1_CLN8	CERS2 CERS6 CERS3	2.87e-07	16	16	3	PF03798
Domain	TLC	CERS2 CERS6 CERS3	2.87e-07	16	16	3	SM00724
Domain	Sphingomyelin_synth-like_dom	SGMS2 SGMS1	2.06e-06	3	16	2	IPR025749
Domain	PAP2_C	SGMS2 SGMS1	2.06e-06	3	16	2	PF14360
Domain	P_Acid_Pase_2/haloperoxidase	SGMS2 SGMS1	1.30e-04	20	16	2	IPR000326
Domain	PAP2	SGMS2 SGMS1	1.30e-04	20	16	2	PF01569
Domain	Homeobox	CERS2 CERS6 CERS3	9.64e-04	234	16	3	PF00046
Domain	HOMEOBOX_1	CERS2 CERS6 CERS3	9.88e-04	236	16	3	PS00027
Domain	HOX	CERS2 CERS6 CERS3	1.00e-03	237	16	3	SM00389
Domain	Homeobox_dom	CERS2 CERS6 CERS3	1.02e-03	239	16	3	IPR001356
Domain	HOMEOBOX_2	CERS2 CERS6 CERS3	1.02e-03	239	16	3	PS50071
Domain	-	CERS2 CERS6 CERS3	1.67e-03	283	16	3	1.10.10.60
Domain	Homeodomain-like	CERS2 CERS6 CERS3	2.62e-03	332	16	3	IPR009057
Pathway	WP_SYNTHESIS_OF_CERAMIDES_AND_1DEOXYCERAMIDES	CERS2 SGMS2 CERS6 CERS3 SGMS1	1.13e-11	22	14	5	M45544
Pathway	WP_SPHINGOLIPID_METABOLISM_OVERVIEW	CERS2 SGMS2 CERS6 CERS3 SGMS1	2.27e-11	25	14	5	MM15931
Pathway	WP_SPHINGOLIPID_METABOLISM_INTEGRATED_PATHWAY	CERS2 SGMS2 CERS6 CERS3 SGMS1	2.81e-11	26	14	5	MM15892
Pathway	WP_SPHINGOLIPID_METABOLISM_INTEGRATED_PATHWAY	CERS2 SGMS2 CERS6 CERS3 SGMS1	2.81e-11	26	14	5	M39784
Pathway	WP_SPHINGOLIPID_METABOLISM_OVERVIEW	CERS2 SGMS2 CERS6 CERS3 SGMS1	3.45e-11	27	14	5	M39863
Pathway	REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS	CERS2 SGMS2 CERS6 CERS3 SGMS1	3.45e-11	27	14	5	MM14646
Pathway	WP_SPHINGOLIPID_PATHWAY	CERS2 SGMS2 CERS6 CERS3 SGMS1	6.07e-11	30	14	5	M39501
Pathway	REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS	CERS2 SGMS2 CERS6 CERS3 SGMS1	1.85e-10	37	14	5	M554
Pathway	REACTOME_SPHINGOLIPID_METABOLISM	CERS2 SGMS2 CERS6 CERS3 SGMS1	2.03e-08	92	14	5	MM15086
Pathway	REACTOME_SPHINGOLIPID_METABOLISM	CERS2 SGMS2 CERS6 CERS3 SGMS1	4.35e-08	107	14	5	M14857
Pathway	WP_METABOLISM_OF_SPHINGOLIPIDS_IN_ER_AND_GOLGI_APPARATUS	SGMS2 CERS3 SGMS1	1.03e-06	21	14	3	M39459
Pathway	REACTOME_METABOLISM_OF_LIPIDS	CERS2 SGMS2 CERS6 CERS3 SGMS1	2.33e-04	620	14	5	MM15193
Pathway	WP_SPHINGOLIPID_METABOLISM_IN_SENESCENCE	CERS2 SGMS2	3.41e-04	28	14	2	M42536
Pathway	REACTOME_METABOLISM_OF_LIPIDS	CERS2 SGMS2 CERS6 CERS3 SGMS1	5.88e-04	757	14	5	M27451
Pathway	KEGG_SPHINGOLIPID_METABOLISM	SGMS2 SGMS1	6.65e-04	39	14	2	M15955
Pathway	KEGG_STARCH_AND_SUCROSE_METABOLISM	TREH UGT2A1	1.18e-03	52	14	2	M14171
Pubmed	Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development.	CERS2 SGMS2 CERS6 CERS3 SGMS1	1.17e-12	27	17	5	23096701
Pubmed	Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil.	CERS2 SGMS2 CERS6 CERS3 SGMS1	1.17e-12	27	17	5	25269881
Pubmed	Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region.	CERS2 CERS6 CERS3	9.69e-10	5	17	3	26887952
Pubmed	Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine.	CERS2 CERS6 CERS3	1.94e-09	6	17	3	17977534
Pubmed	Oxidized phospholipids induce ceramide accumulation in RAW 264.7 macrophages: role of ceramide synthases.	CERS2 CERS6 CERS3	1.94e-09	6	17	3	23936132
Pubmed	Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development.	CERS2 SGMS2 CERS6 SGMS1	2.55e-09	37	17	4	29044125
Pubmed	Sphingomyelin generated by sphingomyelin synthase 1 is involved in attachment and infection with Japanese encephalitis virus.	SGMS2 SGMS1	2.25e-07	2	17	2	27892528
Pubmed	SMS overexpression and knockdown: impact on cellular sphingomyelin and diacylglycerol metabolism, and cell apoptosis.	SGMS2 SGMS1	2.25e-07	2	17	2	17982138
Pubmed	Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells.	SGMS2 SGMS1	2.25e-07	2	17	2	17449912
Pubmed	Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy.	SGMS2 SGMS1	2.25e-07	2	17	2	22106271
Pubmed	Increased ceramide synthase 2 and 6 mRNA levels in breast cancer tissues and correlation with sphingosine kinase expression.	CERS2 CERS6	2.25e-07	2	17	2	19912991
Pubmed	Deficiency of sphingomyelin synthase-1 but not sphingomyelin synthase-2 causes hearing impairments in mice.	SGMS2 SGMS1	2.25e-07	2	17	2	22641779
Pubmed	Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization.	SGMS2 SGMS1	2.25e-07	2	17	2	17616479
Pubmed	2-Hydroxy-oleic acid does not activate sphingomyelin synthase activity.	SGMS2 SGMS1	2.25e-07	2	17	2	30305392
Pubmed	Sphingomyelin synthases regulate protein trafficking and secretion.	SGMS2 SGMS1	2.25e-07	2	17	2	21980337
Pubmed	An inositolphosphorylceramide synthase is involved in regulation of plant programmed cell death associated with defense in Arabidopsis.	SGMS2 SGMS1	2.25e-07	2	17	2	19001565
Pubmed	Carboxyl-terminal Tail-mediated Homodimerizations of Sphingomyelin Synthases Are Responsible for Efficient Export from the Endoplasmic Reticulum.	SGMS2 SGMS1	2.25e-07	2	17	2	27927984
Pubmed	The domain responsible for sphingomyelin synthase (SMS) activity.	SGMS2 SGMS1	2.25e-07	2	17	2	18694848
Pubmed	Deficiency of sphingomyelin synthase 1 but not sphingomyelin synthase 2 reduces bone formation due to impaired osteoblast differentiation.	SGMS2 SGMS1	2.25e-07	2	17	2	31847800
Pubmed	Effect of liver total sphingomyelin synthase deficiency on plasma lipid metabolism.	SGMS2 SGMS1	2.25e-07	2	17	2	33545384
Pubmed	Chlamydia trachomatis-infected human cells convert ceramide to sphingomyelin without sphingomyelin synthases 1 and 2.	SGMS2 SGMS1	2.25e-07	2	17	2	31596951
Pubmed	Loss of ceramide synthase 3 causes lethal skin barrier disruption.	CERS2 CERS3	2.25e-07	2	17	2	22038835
Pubmed	Differential localization of sphingomyelin synthase isoforms in neurons regulates sphingomyelin cluster formation.	SGMS2 SGMS1	2.25e-07	2	17	2	22209789
Pubmed	Ablation of ceramide synthase 2 strongly affects biophysical properties of membranes.	CERS2 SGMS2	2.25e-07	2	17	2	22231783
Pubmed	Sphingomyelin synthases 1 and 2 exhibit phosphatidylcholine phospholipase C activity.	SGMS2 SGMS1	2.25e-07	2	17	2	34774525
Pubmed	Sphingomyelin synthases regulate production of diacylglycerol at the Golgi.	SGMS2 SGMS1	2.25e-07	2	17	2	18370930
Pubmed	Adenovirus-mediated overexpression of sphingomyelin synthases 1 and 2 increases the atherogenic potential in mice.	SGMS2 SGMS1	2.25e-07	2	17	2	16508036
Pubmed	Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2.	CERS2 CERS6 CERS3	3.52e-07	29	17	3	38485951
Pubmed	All members in the sphingomyelin synthase gene family have ceramide phosphoethanolamine synthase activity.	SGMS2 SGMS1	6.74e-07	3	17	2	25605874
Pubmed	Sphingomyelin synthase-related protein SMSr is a phosphatidylethanolamine phospholipase C that promotes nonalcoholic fatty liver disease.	SGMS2 SGMS1	6.74e-07	3	17	2	37586586
Pubmed	Identification of a family of animal sphingomyelin synthases.	SGMS2 SGMS1	6.74e-07	3	17	2	14685263
Pubmed	Sphingomyelin maintains the cutaneous barrier via regulation of the STAT3 pathway.	SGMS2 SGMS1	6.74e-07	3	17	2	35230716
Pubmed	Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells.	CERS2 CERS6	6.74e-07	3	17	2	20406683
Pubmed	Dependence of ABCB1 transporter expression and function on distinct sphingolipids generated by ceramide synthases-2 and -6 in chemoresistant renal cancer.	CERS2 CERS6	6.74e-07	3	17	2	34915026
Pubmed	Impact of sphingomyelin synthase 1 deficiency on sphingolipid metabolism and atherosclerosis in mice.	SGMS2 SGMS1	6.74e-07	3	17	2	22580896
Pubmed	Activation of SIRT1 Enhances Epidermal Permeability Barrier Formation through Ceramide Synthase 2- and 3-Dependent Mechanisms.	CERS2 CERS3	6.74e-07	3	17	2	31958434
Pubmed	SMS regulates the expression and function of P-gp and MRP2 in Caco-2 cells.	SGMS2 SGMS1	1.35e-06	4	17	2	27394416
Pubmed	SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY.	CERS2 CERS6	1.35e-06	4	17	2	26620563
Pubmed	Regulation of cell migration by sphingomyelin synthases: sphingomyelin in lipid rafts decreases responsiveness to signaling by the CXCL12/CXCR4 pathway.	SGMS2 SGMS1	1.35e-06	4	17	2	22688512
Pubmed	Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors.	CERS6 CERS3	1.35e-06	4	17	2	12912983
Pubmed	Do longevity assurance genes containing Hox domains regulate cell development via ceramide synthesis?	CERS6 CERS3	1.35e-06	4	17	2	12297269
Pubmed	The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS.	CERS2 CERS6	1.35e-06	4	17	2	23538298
Pubmed	Modulation of ceramide metabolism in mouse primary macrophages.	SGMS2 SGMS1	1.35e-06	4	17	2	20637730
Pubmed	Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.	CERS2 CERS6	2.25e-06	5	17	2	15823095
Pubmed	SMS2 deficiency impairs PKCδ-regulated B cell tolerance in the germinal center.	SGMS2 SGMS1	2.25e-06	5	17	2	34469734
Pubmed	Sex-specific perturbation of complex lipids in response to medium-chain fatty acids in very long-chain acyl-CoA dehydrogenase deficiency.	CERS2 SGMS2	4.72e-06	7	17	2	31971349
Pubmed	Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis.	CERS2 CERS6	6.29e-06	8	17	2	36543979
Pubmed	Impaired epidermal permeability barrier in mice lacking elovl1, the gene responsible for very-long-chain fatty acid production.	CERS2 CERS3	1.23e-05	11	17	2	23689133
Pubmed	PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega-O-acylceramide synthesis and skin permeability barrier.	CERS2 CERS3	3.83e-05	19	17	2	28369476
Pubmed	FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.	CERS2 ATP13A1 SOAT1 REEP4	6.70e-05	468	17	4	31056421
Pubmed	ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.	CERS2 ATP13A1 CERS6 SOAT1 REEP4	7.15e-05	952	17	5	38569033
Pubmed	The interactome of metabolic enzyme carbonic anhydrase IX reveals novel roles in tumor cell migration and invadopodia/MMP14-mediated invasion.	CERS2 ATP13A1 SOAT1	8.22e-05	176	17	3	28692057
Pubmed	Bcl2L13 is a ceramide synthase inhibitor in glioblastoma.	CERS2 CERS6	1.11e-04	32	17	2	24706805
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	CERS2 ATP13A1 SOAT1 REEP4	1.41e-04	568	17	4	37774976
Pubmed	Defining the membrane proteome of NK cells.	PEX16 CERS2 ATP13A1 CERS6 SGMS1	1.87e-04	1168	17	5	19946888
Pubmed	Assessment of community efforts to advance network-based prediction of protein-protein interactions.	PEX16 ATP13A1 NAA35 REEP4	2.10e-04	630	17	4	36949045
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	UTP20 SCPEP1 ALG3 CERS6 SOAT1	2.13e-04	1201	17	5	35696571
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	PEX16 CERS2 NAA35 SOAT1 REEP4	2.15e-04	1203	17	5	29180619
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	PEX16 CERS2 ATP13A1 CERS6	3.09e-04	697	17	4	28298427
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	ATP13A1 NAA35 ALG3 SOAT1 REEP4	3.38e-04	1327	17	5	32694731
Pubmed	Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs.	ATP13A1 ALG3 CERS6	3.80e-04	296	17	3	34186245
Interaction	TSPAN15 interactions	CERS2 ATP13A1 ALG3 CERS6 REEP4	2.51e-06	276	17	5	int:TSPAN15
Interaction	TTYH1 interactions	PEX16 CERS2 ALG3 CERS6 SOAT1	3.78e-06	300	17	5	int:TTYH1
Interaction	TCTN3 interactions	CERS2 ATP13A1 ALG3 SOAT1 REEP4	6.37e-06	334	17	5	int:TCTN3
Interaction	VIPR2 interactions	CERS2 ALG3 CERS6 REEP4	1.80e-05	194	17	4	int:VIPR2
Interaction	ATP2A1 interactions	PEX16 CERS2 ATP13A1 UTP20 SOAT1	2.00e-05	423	17	5	int:ATP2A1
Interaction	LPAR1 interactions	CERS2 ALG3 CERS6 REEP4	2.45e-05	210	17	4	int:LPAR1
Interaction	SEC62 interactions	CERS2 ATP13A1 CERS6 SOAT1 REEP4	4.71e-05	506	17	5	int:SEC62
Interaction	CCR6 interactions	ATP13A1 ALG3 CERS6	5.41e-05	89	17	3	int:CCR6
Interaction	POMK interactions	CERS2 ALG3 CERS6 REEP4	6.63e-05	271	17	4	int:POMK
Interaction	C3AR1 interactions	PEX16 CERS2 CERS6	7.66e-05	100	17	3	int:C3AR1
Interaction	OPRL1 interactions	PEX16 CERS2 CERS6	8.13e-05	102	17	3	int:OPRL1
Interaction	SYNGR1 interactions	ATP13A1 ALG3 CERS6	9.90e-05	109	17	3	int:SYNGR1
Interaction	TCTN2 interactions	CERS2 ATP13A1 ALG3 SOAT1	1.03e-04	304	17	4	int:TCTN2
Interaction	DIO3 interactions	ATP13A1 SOAT1	1.53e-04	22	17	2	int:DIO3
Interaction	ELOVL4 interactions	PEX16 CERS2 ATP13A1	1.59e-04	128	17	3	int:ELOVL4
Interaction	BIK interactions	PEX16 ATP13A1 REEP4	1.75e-04	132	17	3	int:BIK
Interaction	TMT1A interactions	CERS2 ATP13A1 SOAT1 REEP4	1.96e-04	359	17	4	int:TMT1A
Interaction	ELOVL5 interactions	CERS2 ATP13A1 SOAT1 SGMS1	2.07e-04	364	17	4	int:ELOVL5
Interaction	HSD3B7 interactions	CERS2 ATP13A1 SOAT1 REEP4	2.59e-04	386	17	4	int:HSD3B7
Interaction	HSD17B11 interactions	CERS2 ATP13A1 SOAT1 REEP4	2.69e-04	390	17	4	int:HSD17B11
Interaction	C5AR1 interactions	CERS2 ALG3 REEP4	2.75e-04	154	17	3	int:C5AR1
Interaction	RHOA interactions	CERS2 ATP13A1 UTP20 SOAT1 REEP4 SGMS1	3.07e-04	1199	17	6	int:RHOA
Interaction	OTULINL interactions	CERS2 ATP13A1 SOAT1 REEP4	3.11e-04	405	17	4	int:OTULINL
Interaction	CRELD1 interactions	ALG3 CERS6 SOAT1	3.25e-04	163	17	3	int:CRELD1
Interaction	RPN1 interactions	CERS2 ATP13A1 CERS6 SOAT1 REEP4	4.38e-04	814	17	5	int:RPN1
Interaction	P2RY1 interactions	CERS2 CERS6	6.49e-04	45	17	2	int:P2RY1
Interaction	RANBP1 interactions	SCPEP1 NAA35 SOAT1	6.90e-04	211	17	3	int:RANBP1
Interaction	SCN3B interactions	PEX16 ATP13A1 UTP20	7.19e-04	214	17	3	int:SCN3B
Interaction	CA9 interactions	CERS2 ATP13A1 SOAT1	7.29e-04	215	17	3	int:CA9
Interaction	RETREG3 interactions	CERS2 CERS6 REEP4	8.00e-04	222	17	3	int:RETREG3
Interaction	CADM4 interactions	CERS2 SCPEP1	8.01e-04	50	17	2	int:CADM4
Interaction	VAMP1 interactions	SGMS2 REEP4	9.69e-04	55	17	2	int:VAMP1
Interaction	GYPB interactions	UTP20 REEP4	1.00e-03	56	17	2	int:GYPB
Interaction	VSTM1 interactions	ATP13A1 CERS6	1.00e-03	56	17	2	int:VSTM1
Interaction	PEX16 interactions	PEX16 REEP4	1.23e-03	62	17	2	int:PEX16
Interaction	TXNDC15 interactions	ATP13A1 CERS6	1.31e-03	64	17	2	int:TXNDC15
Interaction	ERGIC1 interactions	CERS2 ATP13A1 SOAT1	1.32e-03	264	17	3	int:ERGIC1
Interaction	SERP1 interactions	ALG3 REEP4	1.39e-03	66	17	2	int:SERP1
Interaction	EFNA5 interactions	CERS2 UTP20	1.48e-03	68	17	2	int:EFNA5
Interaction	PTPRE interactions	CERS2 CERS3	1.52e-03	69	17	2	int:PTPRE
Interaction	TNFSF18 interactions	CERS2 CERS6	1.52e-03	69	17	2	int:TNFSF18
Interaction	SLC30A8 interactions	ATP13A1 REEP4	1.61e-03	71	17	2	int:SLC30A8
Interaction	GPR17 interactions	CERS2 UTP20 CERS6	1.61e-03	283	17	3	int:GPR17
Interaction	DNAJC25 interactions	ATP13A1 SOAT1 REEP4	1.63e-03	284	17	3	int:DNAJC25
Interaction	SLC2A12 interactions	PEX16 CERS6	1.65e-03	72	17	2	int:SLC2A12
Interaction	VSIG1 interactions	UTP20 CERS6	1.65e-03	72	17	2	int:VSIG1
Interaction	LEPROTL1 interactions	PEX16 REEP4	1.89e-03	77	17	2	int:LEPROTL1
Interaction	SLC39A12 interactions	PEX16 CERS6	2.04e-03	80	17	2	int:SLC39A12
Interaction	MFSD14B interactions	PEX16 ATP13A1	2.04e-03	80	17	2	int:MFSD14B
Interaction	GPR21 interactions	ALG3 CERS6	2.09e-03	81	17	2	int:GPR21
Interaction	PTPN5 interactions	CERS2 REEP4	2.40e-03	87	17	2	int:PTPN5
Interaction	PTAR1 interactions	SGMS2 SGMS1	2.40e-03	87	17	2	int:PTAR1
Interaction	GPAA1 interactions	TREH SOAT1	2.46e-03	88	17	2	int:GPAA1
Interaction	PTH1R interactions	CERS6 SOAT1	2.46e-03	88	17	2	int:PTH1R
Interaction	CXCL16 interactions	ATP13A1 UTP20	2.51e-03	89	17	2	int:CXCL16
Interaction	ACKR2 interactions	CERS2 REEP4	2.57e-03	90	17	2	int:ACKR2
Interaction	TMEM128 interactions	SOAT1 REEP4	2.57e-03	90	17	2	int:TMEM128
Interaction	ASGR2 interactions	CERS2 SOAT1	2.62e-03	91	17	2	int:ASGR2
Interaction	CYB5R3 interactions	PEX16 ATP13A1 REEP4	2.67e-03	338	17	3	int:CYB5R3
Interaction	ERGIC3 interactions	PEX16 ATP13A1 ALG3	2.72e-03	340	17	3	int:ERGIC3
Interaction	GPR12 interactions	PEX16 CERS6	2.74e-03	93	17	2	int:GPR12
Interaction	ADGRG5 interactions	CERS6 SOAT1	2.74e-03	93	17	2	int:ADGRG5
Interaction	KIR2DL4 interactions	ATP13A1 CERS6	2.80e-03	94	17	2	int:KIR2DL4
GeneFamily	CERS class homeoboxes	CERS2 CERS6 CERS3	4.46e-09	6	12	3	530
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_DN	CERS2 ATP13A1 SGMS2 ALG3 SOAT1 SGMS1	2.92e-06	681	17	6	M5314
Coexpression	MILI_PSEUDOPODIA_HAPTOTAXIS_DN	CERS2 ATP13A1 SGMS2 ALG3 SOAT1 SGMS1	3.50e-06	703	17	6	MM1055
Coexpression	CHEN_METABOLIC_SYNDROM_NETWORK	TMEM202 TREH SCPEP1 CERS6 SOAT1 REEP4	8.81e-05	1242	17	6	M1920
Coexpression	CHEN_METABOLIC_SYNDROM_NETWORK	TMEM202 TREH SCPEP1 CERS6 SOAT1 REEP4	1.21e-04	1316	17	6	MM1052
ToppCell	kidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CERS2 SCPEP1 SGMS2 CERS6	2.38e-07	145	17	4	47a3bb973a508d3097213a2d86ad1ce697af9bae
Disease	RS-10-hydroxywarfarin to RS-warfarin ratio measurement	SCPEP1 CERS6	1.81e-03	110	17	2	EFO_0803335
Disease	response to xenobiotic stimulus	SCPEP1 SGMS1	4.84e-03	182	17	2	GO_0009410
Disease	S-6-hydroxywarfarin measurement	UTP20 CERS3	1.86e-02	368	17	2	EFO_0803326
Disease	free androgen index	SOAT1 UGT2A1	1.92e-02	374	17	2	EFO_0007005

Protein segments in the cluster

Peptide	Gene	Start	Entry
YVWYFHTLPYLLWAM	ALG3	361	Q92685
LWCLDEYWYYSVFTL	ATP13A1	256	Q9HD20
TLPLWATYYSYRYDW	AGTR2	96	P50052
WYYMIELSFYWSLLF	CERS2	181	Q96G23
PSQYWYYILEMSFYW	CERS3	176	Q8IU89
YYILELSFYWSLMFS	CERS6	181	Q6ZMG9
WFPFYYEIKMAFVLW	REEP4	61	Q9H6H4
MDYLPTWQKIYFYSW	PEX16	321	Q9Y5Y5
EWAFTSLSYLYKYLW	UTP20	146	O75691
DWLYYYAYKDFLWFF	SOAT1	426	P35610
RKDAYMFWWLYYATN	SCPEP1	46	Q9HB40
YYITTRLFWWYHSMA	SGMS2	281	Q8NHU3
IYWYLSEFLYAWLMS	NAA35	521	Q5VZE5
EFYYWDSYWVMEGLL	TREH	171	O43280
AYYITTRLFWWYHTM	SGMS1	336	Q86VZ5
WTYYLNWCSDIFYMF	TMEM202	191	A6NGA9
YMFETLWKSWDSYYS	UGT2A1	221	P0DTE4