Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	microtubule motor activity	KIF24 DNAH5 DYNC1I1 DYNC2H1 DNAH1 DNAI2	6.09e-05	70	194	6	GO:0003777
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYO7B KIF24 DNAH5 DYNC1I1 DYNC2H1 DNAH1 DNAI2	1.56e-04	118	194	7	GO:0003774
GeneOntologyMolecularFunction	dynein light chain binding	DYNC1I1 DYNC2I1 DNAI2	1.86e-04	12	194	3	GO:0045503
GeneOntologyMolecularFunction	nitric-oxide synthase activity	NOS1 NOS2	2.80e-04	3	194	2	GO:0004517
GeneOntologyMolecularFunction	ATP-dependent activity	MCM8 MYO7B KIF24 DDX10 CLPB DNAH5 DYNC1I1 DYNC2H1 TWNK YTHDC2 CHD1L DNAH1 ABCG1 DNAI2 UBA6 SNRNP200	3.42e-04	614	194	16	GO:0140657
GeneOntologyMolecularFunction	dynein heavy chain binding	DYNC1I1 DYNC2I1 DNAI2	5.55e-04	17	194	3	GO:0045504
GeneOntologyMolecularFunction	tetrahydrobiopterin binding	NOS1 NOS2	5.56e-04	4	194	2	GO:0034617
GeneOntologyCellularComponent	dynein complex	DNAH5 DYNC1I1 DYNC2H1 DYNC2I1 DNAH1 DNAI2	1.12e-05	54	196	6	GO:0030286
Domain	NO_synthase	NOS1 NOS2	3.17e-04	3	193	2	PF02898
Domain	NOS_euk	NOS1 NOS2	3.17e-04	3	193	2	IPR012144
Domain	-	NOS1 NOS2	3.17e-04	3	193	2	3.90.340.10
Domain	-	RASA4B RASA4	3.17e-04	3	193	2	4.10.1130.10
Domain	NOS_N	NOS1 NOS2	3.17e-04	3	193	2	IPR004030
Domain	NOS	NOS1 NOS2	3.17e-04	3	193	2	PS60001
Domain	Dynein_heavy_chain_D4_dom	DNAH5 DYNC2H1 DNAH1	3.64e-04	14	193	3	IPR024317
Domain	Dynein_HC_stalk	DNAH5 DYNC2H1 DNAH1	3.64e-04	14	193	3	IPR024743
Domain	Dynein_heavy_dom-2	DNAH5 DYNC2H1 DNAH1	3.64e-04	14	193	3	IPR013602
Domain	DHC_N2	DNAH5 DYNC2H1 DNAH1	3.64e-04	14	193	3	PF08393
Domain	ATPase_dyneun-rel_AAA	DNAH5 DYNC2H1 DNAH1	3.64e-04	14	193	3	IPR011704
Domain	MT	DNAH5 DYNC2H1 DNAH1	3.64e-04	14	193	3	PF12777
Domain	AAA_8	DNAH5 DYNC2H1 DNAH1	3.64e-04	14	193	3	PF12780
Domain	AAA_5	DNAH5 DYNC2H1 DNAH1	3.64e-04	14	193	3	PF07728
Domain	DHC_fam	DNAH5 DYNC2H1 DNAH1	4.51e-04	15	193	3	IPR026983
Domain	Dynein_heavy	DNAH5 DYNC2H1 DNAH1	4.51e-04	15	193	3	PF03028
Domain	Dynein_heavy_dom	DNAH5 DYNC2H1 DNAH1	4.51e-04	15	193	3	IPR004273
Domain	-	PLXNB2 RASA4B RASA4	5.51e-04	16	193	3	1.10.506.10
Domain	-	PLXNB2 SORT1 SEMA3A WDR93 SEMA3B DYNC1I1 WDR62 ATG16L1 WDR70 DYNC2I1 DNAI2	7.15e-04	333	193	11	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	PLXNB2 SORT1 SEMA3A WDR93 SEMA3B DYNC1I1 WDR62 ATG16L1 WDR70 DYNC2I1 DNAI2	7.51e-04	335	193	11	IPR015943
Domain	RasGAP_dom	PLXNB2 RASA4B RASA4	7.91e-04	18	193	3	IPR001936
Domain	Fd_Rdtase_FAD-bd	NOS1 NOS2 DUOX2	9.32e-04	19	193	3	IPR017927
Domain	FAD_FR	NOS1 NOS2 DUOX2	9.32e-04	19	193	3	PS51384
Domain	Riboflavin_synthase-like_b-brl	NOS1 NOS2 DUOX2	9.32e-04	19	193	3	IPR017938
Domain	YTH	YTHDC1 YTHDC2	1.04e-03	5	193	2	PF04146
Domain	Autophagy-rel_C	VPS13C ATG2B	1.04e-03	5	193	2	IPR015412
Domain	ATG_C	VPS13C ATG2B	1.04e-03	5	193	2	PF09333
Domain	YTH_domain	YTHDC1 YTHDC2	1.04e-03	5	193	2	IPR007275
Domain	YTH	YTHDC1 YTHDC2	1.04e-03	5	193	2	PS50882
Domain	PX	SNX13 SNX30 SNX10 PLD2	1.09e-03	44	193	4	SM00312
Domain	FERM_M	MYO7B KRIT1 FRMD5 EPB41L1	1.28e-03	46	193	4	PF00373
Domain	FAD_binding_1	NOS1 NOS2	1.55e-03	6	193	2	PF00667
Domain	-	NOS1 NOS2	1.55e-03	6	193	2	1.20.990.10
Domain	FAD-binding_1	NOS1 NOS2	1.55e-03	6	193	2	IPR003097
Domain	EF-hand_dom_typ1	UTRN DYTN	1.55e-03	6	193	2	IPR015153
Domain	EF-hand_dom_typ2	UTRN DYTN	1.55e-03	6	193	2	IPR015154
Domain	EF-hand_2	UTRN DYTN	1.55e-03	6	193	2	PF09068
Domain	EF-hand_3	UTRN DYTN	1.55e-03	6	193	2	PF09069
Domain	NADPH_Cyt_P450_Rdtase_dom3	NOS1 NOS2	1.55e-03	6	193	2	IPR023173
Domain	-	MYO7B KRIT1 FRMD5 EPB41L1	1.63e-03	49	193	4	1.20.80.10
Domain	PX	SNX13 SNX30 SNX10 PLD2	1.63e-03	49	193	4	PF00787
Domain	FERM_central	MYO7B KRIT1 FRMD5 EPB41L1	1.63e-03	49	193	4	IPR019748
Domain	FERM_domain	MYO7B KRIT1 FRMD5 EPB41L1	1.63e-03	49	193	4	IPR000299
Domain	PX	SNX13 SNX30 SNX10 PLD2	1.76e-03	50	193	4	PS50195
Domain	FERM/acyl-CoA-bd_prot_3-hlx	MYO7B KRIT1 FRMD5 EPB41L1	1.76e-03	50	193	4	IPR014352
Domain	FERM_1	MYO7B KRIT1 FRMD5 EPB41L1	1.76e-03	50	193	4	PS00660
Domain	FERM_2	MYO7B KRIT1 FRMD5 EPB41L1	1.76e-03	50	193	4	PS00661
Domain	FERM_3	MYO7B KRIT1 FRMD5 EPB41L1	1.76e-03	50	193	4	PS50057
Domain	Band_41_domain	MYO7B KRIT1 FRMD5 EPB41L1	1.76e-03	50	193	4	IPR019749
Domain	B41	MYO7B KRIT1 FRMD5 EPB41L1	1.76e-03	50	193	4	SM00295
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	EPHB6 LRP1B DSCAML1 RXRG STAB1 NAA25 WIZ CLPB SACS MTMR3 ASTN2 TAF6 QARS1 UTRN DYNC1I1 USP13 SETMAR FOXRED1 SORBS2 CLIP2 DYNC2I1 KRIT1 POLR3B EIF4G2 MAST1 YY1AP1 SNRNP200 AFF4 RPL15	3.12e-10	1285	199	29	35914814
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ZNF585A RPS6KA2 ADGRB2 COMTD1 PLXNB2 MYORG SNX30 BMP8B WIZ PSME4 TMEM259 MTMR3 AP1G2 GPAT4 ANKRD13D HSPG2 WDR70 SHC1 TWNK MYOF DUSP16 DIP2C SNAPC4 SMAD7 KLHL17	5.57e-09	1105	199	25	35748872
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	NUMBL BCKDHA PLXNB2 NSRP1 DDX10 GRAMD1B DNAJC10 CLPB SACS CASKIN2 SUPT6H P3H1 DNAJC12 COL14A1 GPAT4 WDR62 PML DYNC2H1 TWNK ESF1 P4HA1 TRAM1 EIF4G2 UBA6 SNRNP200 EPB41L1 RPL15 FTSJ3	3.27e-08	1487	199	28	33957083
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	GALNT3 DAG1 PLXNB2 LRP1B MYORG SORT1 SEMA3A GRAMD1B DNAJC10 TMEM259 P3H1 SEMA3B POFUT2 GPAT4 WDR62 HSPG2 NPTX1 COL12A1 MYOF P4HA1 TRAM1 EDEM1 FRMD5 GALNT4	1.17e-07	1201	199	24	35696571
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	GABRE SGSM1 MCM8 NUMBL VPS13C RPS6KA2 NSRP1 SNX30 SUPT6H EHF SEMA3B ASTN2 CYB5D1 POLK UTRN CCDC32 WDR70 DYNC2I1 CHD1L DNAH1 ABCG1 UBA6 DIP2C MAST1 SCAF11 EPB41L1 AFF4	1.26e-07	1489	199	27	28611215
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	GALNT3 NUMBL COMTD1 YTHDC1 MFF DDX10 WIZ CLPB SUPT6H TAF6 UTRN SET PCDHB7 ARHGEF12 TWNK YTHDC2 ESF1 ORC5 MYOF P4HA1 INTS13 TRAM1 EIF4G2 SCAF11 EPB41L1 AFF4	5.00e-07	1497	199	26	31527615
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	EPHB6 RPS6KA2 SRMS PLXNB2 LRP1B SEMA3B MTMR3 USP4 MMP3 DNAH5 SEC23B GLT6D1 POLR3B CSK UBA6 GALNT4 KLHL17	1.20e-06	730	199	17	34857952
Pubmed	Dp71 gene disruption alters the composition of the dystrophin-associated protein complex and neuronal nitric oxide synthase expression in the hypothalamic supraoptic and paraventricular nuclei.	DAG1 NOS1 UTRN	1.83e-06	5	199	3	22493004
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	MYORG BMP3 DNAJC10 P3H1 TRHDE HSPG2 P4HA1 EDEM1	5.08e-06	164	199	8	32409323
Pubmed	Tyrosine phosphorylation of beta-dystroglycan at its WW domain binding motif, PPxY, recruits SH2 domain containing proteins.	DAG1 SHC1 CSK	6.35e-06	7	199	3	11724572
Pubmed	Absence of acetylcholinesterase at the neuromuscular junctions of perlecan-null mice.	DAG1 UTRN HSPG2	6.35e-06	7	199	3	11802174
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	NUMBL FAM114A2 NSRP1 DDX10 WIZ TAF6 UTRN WDR62 PML WDR70 ATG2B YTHDC2 ESF1 EIF4G2 SNRNP200 AFF4 RPL15 FTSJ3	8.03e-06	934	199	18	33916271
Pubmed	Loss of short dystrophin isoform Dp71 in olfactory ensheathing cells causes vomeronasal nerve defasciculation in mouse olfactory system.	DAG1 UTRN HSPG2	1.01e-05	8	199	3	18586242
Pubmed	Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis.	BMP3 BMP8B BMP8A	1.51e-05	9	199	3	1460021
Pubmed	Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population.	DAG1 STAB1 SEMA3B USP4 SLC6A4	2.90e-05	62	199	5	19367581
Pubmed	Collagen types XII and XIV are present in basement membrane zones during human embryonic development.	COL14A1 COL12A1	3.26e-05	2	199	2	15609093
Pubmed	CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.	RASA4B RASA4	3.26e-05	2	199	2	11448776
Pubmed	Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.	NOS1 NOS2	3.26e-05	2	199	2	7682706
Pubmed	The role of nitric oxide synthases in the sleep responses to tumor necrosis factor-alpha.	NOS1 NOS2	3.26e-05	2	199	2	15157956
Pubmed	Effects of ethanol on neutrophil recruitment and lung host defense in nitric oxide synthase I and nitric oxide synthase II knockout mice.	NOS1 NOS2	3.26e-05	2	199	2	10512307
Pubmed	[Expression of cell adhesion molecule and nitric oxide synthase in nasal mucosa in allergic rhinitis].	NOS1 NOS2	3.26e-05	2	199	2	16780147
Pubmed	Identification of residues that confer sugar selectivity to UDP-glycosyltransferase 3A (UGT3A) enzymes.	UGT3A1 UGT3A2	3.26e-05	2	199	2	22621930
Pubmed	Inducible-NOS but not neuronal-NOS participate in the acute effect of TNF-alpha on hypothalamic insulin-dependent inhibition of food intake.	NOS1 NOS2	3.26e-05	2	199	2	16876161
Pubmed	Involvement of inducible nitric oxide synthase in cardiac dysfunction with tumor necrosis factor-alpha.	NOS2 CLIP2	3.26e-05	2	199	2	12003824
Pubmed	Role of nitric oxide synthase in the development of bone cancer pain and effect of L-NMMA.	NOS1 NOS2	3.26e-05	2	199	2	26648027
Pubmed	Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis.	BMP8B BMP8A	3.26e-05	2	199	2	9463357
Pubmed	The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse.	BMP8B BMP8A	3.26e-05	2	199	2	8682296
Pubmed	Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme.	NOS1 NOS2	3.26e-05	2	199	2	1379716
Pubmed	A conserved Val to Ile switch near the heme pocket of animal and bacterial nitric-oxide synthases helps determine their distinct catalytic profiles.	NOS1 NOS2	3.26e-05	2	199	2	14976216
Pubmed	Family-based association study between NOS-I and -IIA polymorphisms and autism spectrum disorders in Korean trios.	NOS1 NOS2	3.26e-05	2	199	2	18563708
Pubmed	The spinal cord expression of neuronal and inducible nitric oxide synthases and their contribution in the maintenance of neuropathic pain in mice.	NOS1 NOS2	3.26e-05	2	199	2	21179208
Pubmed	Spontaneous sleep in mice with targeted disruptions of neuronal or inducible nitric oxide synthase genes.	NOS1 NOS2	3.26e-05	2	199	2	12738065
Pubmed	Deficiency of iNOS does not attenuate severe congestive heart failure in mice.	NOS1 NOS2	3.26e-05	2	199	2	15319210
Pubmed	The COL12A1 and COL14A1 genes and Achilles tendon injuries.	COL14A1 COL12A1	3.26e-05	2	199	2	17960519
Pubmed	The protective role of bone morphogenetic protein-8 in the glucocorticoid-induced apoptosis on bone cells.	BMP8B BMP8A	3.26e-05	2	199	2	21277400
Pubmed	Association between inducible and neuronal nitric oxide synthase polymorphisms and recurrent depressive disorder.	NOS1 NOS2	3.26e-05	2	199	2	20888049
Pubmed	Mechanistic studies on the intramolecular one-electron transfer between the two flavins in the human neuronal nitric-oxide synthase and inducible nitric-oxide synthase flavin domains.	NOS1 NOS2	3.26e-05	2	199	2	12777376
Pubmed	Long non‑coding RNA AL355711 promotes smooth muscle cell migration through the ABCG1/MMP3 pathway.	MMP3 ABCG1	3.26e-05	2	199	2	34608503
Pubmed	Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease.	NOS1 NOS2	3.26e-05	2	199	2	10581083
Pubmed	Functional variants in NOS1 and NOS2A are not associated with progressive hearing loss in Ménière's disease in a European Caucasian population.	NOS1 NOS2	3.26e-05	2	199	2	21612410
Pubmed	Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases.	NOS1 NOS2	3.26e-05	2	199	2	28800639
Pubmed	Association between Parkinson's disease and polymorphisms in the nNOS and iNOS genes in a community-based case-control study.	NOS1 NOS2	3.26e-05	2	199	2	12490535
Pubmed	Intra- and inter-molecular effects of a conserved arginine residue of neuronal and inducible nitric oxide synthases on FMN and calmodulin binding.	NOS1 NOS2	3.26e-05	2	199	2	23507581
Pubmed	Nitric oxide mediates selective degeneration of hypothalamic orexin neurons through dysfunction of protein disulfide isomerase.	NOS1 NOS2	3.26e-05	2	199	2	23904594
Pubmed	Human BMP8A suppresses luteinization of rat granulosa cells via the SMAD1/5/8 pathway.	BMP8B BMP8A	3.26e-05	2	199	2	31940275
Pubmed	Abnormal corneal endothelial maturation in collagen XII and XIV null mice.	COL14A1 COL12A1	3.26e-05	2	199	2	23599329
Pubmed	Roles of iNOS and nNOS in sepsis-induced pulmonary apoptosis.	NOS1 NOS2	3.26e-05	2	199	2	14660484
Pubmed	Role of inducible or neuronal nitric oxide synthase in neurogenesis of the dentate gyrus in aged mice.	NOS1 NOS2	3.26e-05	2	199	2	21082337
Pubmed	Pyroptotic and apoptotic cell death in iNOS and nNOS overexpressing K562 cells: A mechanistic insight.	NOS1 NOS2	3.26e-05	2	199	2	31881190
Pubmed	Inducible nitric oxide synthase is involved in acid-induced gastric hyperemia in rats and mice.	NOS1 NOS2	3.26e-05	2	199	2	12646421
Pubmed	Brain dystrophin-glycoprotein complex: persistent expression of beta-dystroglycan, impaired oligomerization of Dp71 and up-regulation of utrophins in animal models of muscular dystrophy.	DAG1 UTRN	3.26e-05	2	199	2	11178104
Pubmed	A defect in a novel ADAMTS family member is the cause of the belted white-spotting mutation.	DCT ADAMTS20	3.26e-05	2	199	2	12925592
Pubmed	Chronic alcohol consumption induces an overproduction of NO by nNOS- and iNOS-expressing myenteric neurons in the murine small intestine.	NOS1 NOS2	3.26e-05	2	199	2	21470341
Pubmed	Nitric oxide synthases: roles, tolls, and controls.	NOS1 NOS2	3.26e-05	2	199	2	7522969
Pubmed	Contribution of inducible and neuronal nitric oxide synthases to mitochondrial damage and melatonin rescue in LPS-treated mice.	NOS1 NOS2	3.26e-05	2	199	2	28110436
Pubmed	Influenza virus-induced sleep responses in mice with targeted disruptions in neuronal or inducible nitric oxide synthases.	NOS1 NOS2	3.26e-05	2	199	2	15220315
Pubmed	Phosphotyrosine binding domains of Shc and insulin receptor substrate 1 recognize the NPXpY motif in a thermodynamically distinct manner.	SHC1 CSK	3.26e-05	2	199	2	10037694
Pubmed	Adhesion-dependent tyrosine phosphorylation of (beta)-dystroglycan regulates its interaction with utrophin.	DAG1 UTRN	3.26e-05	2	199	2	10769203
Pubmed	Role of different nitric oxide synthase isoforms in a murine model of acute lung injury and sepsis.	NOS1 NOS2	3.26e-05	2	199	2	20655878
Pubmed	New mutations in DYNC2H1 and WDR60 genes revealed by whole-exome sequencing in two unrelated Sardinian families with Jeune asphyxiating thoracic dystrophy.	DYNC2H1 DYNC2I1	3.26e-05	2	199	2	26874042
Pubmed	MCM8 promotes lung cancer progression through upregulating DNAJC10.	MCM8 DNAJC10	3.26e-05	2	199	2	39031896
Pubmed	Role of Nitric Oxide in Stress-Induced Anxiety: From Pathophysiology to Therapeutic Target.	NOS1 NOS2	3.26e-05	2	199	2	28061969
Pubmed	Structural basis of an ERAD pathway mediated by the ER-resident protein disulfide reductase ERdj5.	DNAJC10 EDEM1	3.26e-05	2	199	2	21329881
Pubmed	Binding of perlecan to transthyretin in vitro.	TTR HSPG2	3.26e-05	2	199	2	9307034
Pubmed	An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.	RASA4B RASA4	3.26e-05	2	199	2	16041389
Pubmed	Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.	NOS1 NOS2	3.26e-05	2	199	2	1372907
Pubmed	Polymorphisms of the neuronal and inducible nitric oxide synthase genes and the risk of cutaneous melanoma: a case-control study.	NOS1 NOS2	3.26e-05	2	199	2	17328085
Pubmed	Increased nitric oxide caused by the ketogenic diet reduces the onset time of kainic acid-induced seizures in ICR mice.	NOS1 NOS2	3.26e-05	2	199	2	16460714
Pubmed	Post-translational maturation of dystroglycan is necessary for pikachurin binding and ribbon synaptic localization.	DAG1 EGFLAM	3.26e-05	2	199	2	20682766
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	NUMBL BCKDHA SORT1 TRIM11 WIZ CASKIN2 P3H1 MTMR3 PDP2 UTRN ARMT1 SHC1 ESF1 CSK P4HA1 DUSP16 EPB41L1 FTSJ3	3.72e-05	1049	199	18	27880917
Pubmed	Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.	DDX10 WIZ SET WDR70 YTHDC2 ESF1 SCAF11 SNRNP200 AFF4	4.02e-05	283	199	9	30585729
Pubmed	Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant.	VPS13C ADGRB2 BCKDHA NPTX1 SORBS2 CLIP2 ADCK1 DYNC2I1 SLC6A4 MAST1 EPB41L1	4.17e-05	430	199	11	32581705
Pubmed	The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning.	DNAH5 DYNC2H1 NPHP3	5.06e-05	13	199	3	17884984
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	BMP3 POLK UTRN NOS2 HSPG2 COL12A1 MYOF DUSP16 EIF4G2 KLHL17	5.06e-05	363	199	10	14691545
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	VPS13C BCKDHA PLXNB2 MFF WIZ CLPB MTMR3 GPAT4 SEC23B WDR62 FOXRED1 PCLO ATG2B SHC1 DYNC2I1 TWNK YTHDC2 ZDBF2 ESF1 COA1 UQCC1 FTSJ3	5.16e-05	1496	199	22	32877691
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH5 DYNC2H1 DNAH1	6.41e-05	14	199	3	9373155
Pubmed	The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation.	PLXNB2 SEMA3A SEMA3B	6.41e-05	14	199	3	22955271
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	PHF20 DAG1 BCKDHA YTHDC1 KIF24 NSRP1 NAA25 PDP2 POFUT2 CHD1L SCAF11 EPB41L1	6.75e-05	536	199	12	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	PHF20 DAG1 BCKDHA YTHDC1 KIF24 NSRP1 NAA25 PDP2 POFUT2 CHD1L SCAF11 EPB41L1	7.00e-05	538	199	12	10512203
Pubmed	O-glycosylation modulates integrin and FGF signalling by influencing the secretion of basement membrane components.	GALNT3 SEC23B EDEM1 GALNT4	8.09e-05	40	199	4	22643896
Pubmed	Human immunodeficiency virus-1-infected macrophages induce inducible nitric oxide synthase and nitric oxide (NO) production in astrocytes: astrocytic NO as a possible mediator of neural damage in acquired immunodeficiency syndrome.	NOS1 NOS2	9.74e-05	3	199	2	10068656
Pubmed	N-terminal α Dystroglycan (αDG-N): A Potential Serum Biomarker for Duchenne Muscular Dystrophy.	DAG1 UTRN	9.74e-05	3	199	2	27854211
Pubmed	Crucial roles of nitric oxide synthases in β-adrenoceptor-mediated bladder relaxation in mice.	NOS1 NOS2	9.74e-05	3	199	2	27784691
Pubmed	Nitric oxide synthase gene knockout mice do not become hypertensive during pregnancy.	NOS1 NOS2	9.74e-05	3	199	2	11717657
Pubmed	Estrogen induces nitric oxide production via activation of constitutive nitric oxide synthases in human neuroblastoma cells.	NOS1 NOS2	9.74e-05	3	199	2	15242984
Pubmed	Secretagogue-stimulated pancreatic secretion is differentially regulated by constitutive NOS isoforms in mice.	NOS1 NOS2	9.74e-05	3	199	2	14551061
Pubmed	Nitric oxide synthases and heart failure - lessons from genetically manipulated mice.	NOS1 NOS2	9.74e-05	3	199	2	23774658
Pubmed	Human immunodeficiency virus infection, inducible nitric oxide synthase expression, and microglial activation: pathogenetic relationship to the acquired immunodeficiency syndrome dementia complex.	NOS1 NOS2	9.74e-05	3	199	2	10443886
Pubmed	Paradoxical roles of different nitric oxide synthase isoforms in colonic injury.	NOS1 NOS2	9.74e-05	3	199	2	14665440
Pubmed	Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease.	NOS1 NOS2	9.74e-05	3	199	2	24192154
Pubmed	A new look at cytoskeletal NOS-1 and β-dystroglycan changes in developing muscle and brain in control and mdx dystrophic mice.	DAG1 NOS1	9.74e-05	3	199	2	23940011
Pubmed	Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in the initiation and maintenance of spermatogenesis in the mouse.	BMP8B BMP8A	9.74e-05	3	199	2	9076678
Pubmed	Deletion of neuronal NOS prevents impaired vasodilation in septic mouse skeletal muscle.	NOS1 NOS2	9.74e-05	3	199	2	17258180
Pubmed	Brainstem prolactin mRNA is enhanced in mice with suppressed neuronal nitric oxide synthase activity.	NOS1 NOS2	9.74e-05	3	199	2	15469894
Pubmed	Neuronal nitric oxide synthase-rescue of dystrophin/utrophin double knockout mice does not require nNOS localization to the cell membrane.	NOS1 UTRN	9.74e-05	3	199	2	22003386
Pubmed	Matrilysin/MMP-7 Cleavage of Perlecan/HSPG2 Complexed with Semaphorin 3A Supports FAK-Mediated Stromal Invasion by Prostate Cancer Cells.	SEMA3A HSPG2	9.74e-05	3	199	2	29740048
Pubmed	Utrophin A is essential in mediating the functional adaptations of mdx mouse muscle following chronic AMPK activation.	DAG1 UTRN	9.74e-05	3	199	2	25324540
Pubmed	Adiponectin increases MMP-3 expression in human chondrocytes through AdipoR1 signaling pathway.	MMP3 ADIPOR1	9.74e-05	3	199	2	21321996
Pubmed	Resequencing three candidate genes for major depressive disorder in a Dutch cohort.	PCLO SLC6A4	9.74e-05	3	199	2	24278217
Pubmed	CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane.	RASA4B RASA4	9.74e-05	3	199	2	25637021
Interaction	P4HA2 interactions	MCM8 SRMS ERFE SACS COL14A1 CLNK WDR62 COL12A1 POLR3B P4HA1	8.79e-07	138	193	10	int:P4HA2
Cytoband	15q15.3	ZSCAN29 STRCP1 DUOX2 FRMD5	4.03e-06	25	199	4	15q15.3
Cytoband	2q33.3	MDH1B DYTN ZDBF2	2.99e-04	30	199	3	2q33.3
Cytoband	5p13.2	UGT3A1 UGT3A2 WDR70	3.30e-04	31	199	3	5p13.2
GeneFamily	Bone morphogenetic proteins\|Astacins	BMP3 BMP8B BMP8A	7.01e-05	11	139	3	455
GeneFamily	Fibronectin type III domain containing	EPHB6 DSCAML1 ASTN2 COL14A1 COL12A1 EGFLAM MYOM2	2.39e-04	160	139	7	555
GeneFamily	Dyneins, axonemal	DNAH5 DNAH1 DNAI2	2.79e-04	17	139	3	536
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	MYO7B KRIT1 FRMD5 EPB41L1	5.86e-04	50	139	4	1293
GeneFamily	SH2 domain containing	SRMS SUPT6H CLNK SHC1 CSK	1.10e-03	101	139	5	741
GeneFamily	Sorting nexins\|PX-BAR domain containing	SNX13 SNX30 SNX10	1.40e-03	29	139	3	754
GeneFamily	Autophagy related	SNX30 ATG16L1 ATG2B	2.05e-03	33	139	3	1022
GeneFamily	Pleckstrin homology domain containing\|SH2 domain containing\|C2 and RasGAP domain containing	RASA4B RASA4	2.54e-03	10	139	2	830
GeneFamily	AAA ATPases\|Mitochondrial respiratory chain complex assembly factors	FOXRED1 COA1 UQCC1	3.57e-03	40	139	3	645
GeneFamily	WD repeat domain containing	WDR93 DYNC1I1 WDR62 ATG16L1 WDR70 DYNC2I1 DNAI2	4.18e-03	262	139	7	362
GeneFamily	Dyneins, cytoplasmic	DYNC1I1 DYNC2H1	4.33e-03	13	139	2	538
Coexpression	GSE17721_LPS_VS_CPG_16H_BMDC_UP	IRF7 PPT2 DNAJC12 NOS2 PML FOXRED1 DNAH1 P4HA1 UQCC1 EDEM1	2.99e-06	200	197	10	M4007
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO7B LRP1B DSCAML1 ADAMTS20 DNAH5 TRHDE COL12A1 PCLO DNAH1 LOXHD1 ASXL3 MYOM2 ANO3	2.49e-12	184	199	13	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO7B LRP1B DSCAML1 ADAMTS20 DNAH5 TRHDE COL12A1 PCLO DNAH1 LOXHD1 ASXL3 MYOM2 ANO3	2.49e-12	184	199	13	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO7B LRP1B DSCAML1 ADAMTS20 DNAH5 TRHDE COL12A1 PCLO DNAH1 LOXHD1 ASXL3 MYOM2 ANO3	2.49e-12	184	199	13	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Myeloid-Megakaryocyte\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	FAM114A2 YTHDC1 SNX13 STAB1 PSME4 TMEM259 SNX10 NKIRAS2 DUSP16	3.07e-07	200	199	9	0d76b006d8e8b32174e65e400acd0674354b962c
ToppCell	Parenchymal-10x3prime_v2-Immune_Myeloid-Myeloid\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	FAM114A2 YTHDC1 SNX13 STAB1 PSME4 TMEM259 SNX10 NKIRAS2 DUSP16	3.07e-07	200	199	9	cc8368665bc6bb7c4f39632ccff07ceaa98a7b65
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SGSM1 LRP1B TFCP2L1 EHF ASTN2 COL14A1 NOS1 EPB41L1	1.83e-06	184	199	8	d33de57876817050b294f2ecb0a4eb0634cfa7f0
ToppCell	NS-moderate-d_16-33-Epithelial-Ciliated\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	MYCBPAP WDR93 MDH1B DNAH5 DYNC2H1 CFAP210 DNAI2 CFAP58	1.90e-06	185	199	8	5e689c2fb36ce3ac2adc8d15f67107f21cf68868
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH7 LRP1B TFCP2L1 SNX10 ASTN2 COL14A1 NOS1 MYOF	2.06e-06	187	199	8	77886f99c229610abd28c4c370d2c7d1536c9782
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH7 LRP1B SNX10 TRHDE CLIP2 DYNC2H1 MYOF EPB41L1	2.23e-06	189	199	8	e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCell	facs-Lung-nan-3m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SGSM1 THSD1 STAB1 SEMA3A UTRN ARHGEF12 DUOX2 EIF4G2	2.82e-06	195	199	8	7f9b7f15006610ad591063d90e90367bd6083c7f
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYCBPAP MDH1B DYNC2H1 DYNC2I1 CFAP210 DNAH1 DNAI2	1.12e-05	169	199	7	fba841664939c771881ba97f14ef1df6635c04ff
ToppCell	droplet-Lung-LUNG-30m-Epithelial-club_cell_of_bronchiole\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTR TFCP2L1 EHF DNAH5 SORBS2 DNAH1 STKLD1	1.51e-05	177	199	7	7ac99ff16df94b4e08d361e3d98a7b3af8d6ee3b
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EHF SEMA3B NOS2 ANKRD13D CFAP210 MYOF UBA6	1.51e-05	177	199	7	14fb8d182775dfd0e49aa7e4e12543a85b3b8bd6
ToppCell	droplet-Lung-LUNG-30m-Epithelial-Club_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTR TFCP2L1 EHF DNAH5 SORBS2 DNAH1 STKLD1	1.51e-05	177	199	7	092a345cb802f183322aa5542341ba2d96d4f06a
ToppCell	ASK454-Epithelial-Ciliated\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	MDH1B DNAH5 DYNC2I1 CFAP210 DNAI2 CFAP58 ANO3	1.63e-05	179	199	7	f21919ef9d3d984e2925ef3d24f89e20fe265dcd
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KCNH7 LRP1B SEMA3A NPTX1 RGS6 MYOM2 ANO3	1.75e-05	181	199	7	9de2f2cc5f02e0ca599c9e0d2cb1e1e4b5aac112
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DSCAML1 SEMA3B UTRN HSPG2 MYOF FADS3 SUSD2	1.75e-05	181	199	7	b45b11428d13950369347e051d4d517efb2bd4fd
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH7 SGSM1 GRAMD1B TFCP2L1 SNX10 MMP3 NOS1	1.75e-05	181	199	7	e0abf2707d9e0aa942c657eef7d2cbcd02f060dd
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-M/X_cells_(MLN/GHRL+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCNH7 TTR SORBS2 PCLO ADCK1 RASA4 SUSD2	1.75e-05	181	199	7	af031661af28f99d906d8e013b4949133b44a2e6
ToppCell	ASK454-Epithelial\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	SEMA3B MDH1B COL12A1 SLC6A4 FADS3 SUSD2 DNAI2	1.81e-05	182	199	7	ab15316cff989b61ff397a866d7ca8b49c13e981
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCBPAP ASTN2 TWNK NPHP3 CSK DNAI2 EGFLAM	1.81e-05	182	199	7	c84f44391932080df31c8765e363c3dff64b2bd1
ToppCell	COVID-19-kidney-Distal_Epi_Doublet_(PCT)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LRP1B DSCAML1 TFCP2L1 ASTN2 TRHDE PCLO EPB41L1	1.81e-05	182	199	7	9d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCell	droplet-Lung-21m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GALNT3 SORT1 SNX10 SLC6A4 MYOF ABCG1 EPB41L1	1.94e-05	184	199	7	15ea746c77785120f69f9ab370fb7eb9b70692f8
ToppCell	droplet-Lung-18m-Hematologic-myeloid-alveolar_macrophage\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GALNT3 SORT1 SNX10 SLC6A4 MYOF ABCG1 DIP2C	1.94e-05	184	199	7	8fa30789c9d583188667cf375d2218e392dd40bc
ToppCell	droplet-Lung-21m-Hematologic-myeloid-alveolar_macrophage\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GALNT3 SORT1 SNX10 SLC6A4 MYOF ABCG1 EPB41L1	1.94e-05	184	199	7	bd5e8fc453a6393b8778734a2c3c2f1281769bcd
ToppCell	droplet-Lung-18m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GALNT3 SORT1 SNX10 SLC6A4 MYOF ABCG1 DIP2C	2.01e-05	185	199	7	4bee178ede12f56ba5f5bec44a03dc2a62c50137
ToppCell	droplet-Lung-nan-18m-Epithelial-Ciliated_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCBPAP WDR93 MDH1B TTC22 DNAH5 DNAH1 CFAP58	2.08e-05	186	199	7	740fd06bcd3b24e6ff2ecf8080f378afc3e95084
ToppCell	facs-Heart-LA-24m-Myeloid-macrophage\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SGSM1 GNMT TTR EHF AP1G2 NPTX1 SLC6A4	2.08e-05	186	199	7	246503fd4e6ae24041c606b069eb5fb313e60f73
ToppCell	facs-Heart-LA-24m-Myeloid-macrophage\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SGSM1 GNMT TTR EHF AP1G2 NPTX1 SLC6A4	2.08e-05	186	199	7	ef93ac469eb4f63db036f14b442c1503b8c6de38
ToppCell	droplet-Lung-nan-18m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCBPAP WDR93 MDH1B TTC22 DNAH5 DNAH1 CFAP58	2.08e-05	186	199	7	5ab43a298d23238b34e898d11decf0ad81d1b14e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LRP1B TFCP2L1 ASTN2 COL14A1 DNAH5 MYOF RGS6	2.16e-05	187	199	7	87b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCell	droplet-Lung-nan-18m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNT3 SORT1 SNX10 SLC6A4 MYOF ABCG1 DIP2C	2.16e-05	187	199	7	f0c6e53035b00772377c4d5f761b4d11026b911a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LRP1B TFCP2L1 ASTN2 COL14A1 DNAH5 MYOF RGS6	2.16e-05	187	199	7	42a1267bfc27b4460b8409ada580a87c4385841c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LRP1B TFCP2L1 ASTN2 COL14A1 DNAH5 MYOF RGS6	2.16e-05	187	199	7	64afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCell	P15-Epithelial-airway_epithelial_cell-club_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TMC3 MYCBPAP DNAH5 DNAH1 SUSD2 DNAI2 CFAP58	2.16e-05	187	199	7	a70aaae32426e9ddb1cbfbd0e0db24ccc96b9f40
ToppCell	droplet-Lung-nan-18m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GALNT3 SORT1 SNX10 SLC6A4 MYOF ABCG1 DIP2C	2.16e-05	187	199	7	f20e7a1751694390f535ffb27b97e887220f8695
ToppCell	facs-Heart-LA-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SACS MTMR3 FOXRED1 SORBS2 RGS6 UQCC1 EPB41L1	2.16e-05	187	199	7	f1e9877d859369b862d4a559ec9ab9be74a67a96
ToppCell	facs-Heart-LA-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SACS MTMR3 FOXRED1 SORBS2 RGS6 UQCC1 EPB41L1	2.16e-05	187	199	7	3ffbd50b49059dcd3e23c5ac01901e4352142446
ToppCell	COVID-19-kidney\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LRP1B DSCAML1 TFCP2L1 ASTN2 TRHDE PCLO EPB41L1	2.16e-05	187	199	7	d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	KCNH7 LRP1B SNX10 CLIP2 DYNC2H1 MYOF EPB41L1	2.16e-05	187	199	7	f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCell	COVID-19-kidney-DCT\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LRP1B DSCAML1 TFCP2L1 SNX10 TRHDE DYNC2H1 EPB41L1	2.23e-05	188	199	7	1d56cd409793f05cca20757ab26e91f1a1ee67b5
ToppCell	droplet-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYCBPAP WDR93 MDH1B DNAH5 DNAH1 DNAI2 CFAP58	2.23e-05	188	199	7	0eca3dc93724e23b71e687fc24fa9f1e89bdef6a
ToppCell	droplet-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYCBPAP WDR93 MDH1B DNAH5 DNAH1 DNAI2 CFAP58	2.23e-05	188	199	7	9ce3e1fffce87ad19812ecbf9b7f9935a975d676
ToppCell	P15-Epithelial-airway_epithelial_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TMC3 MYCBPAP DNAH5 DNAH1 SUSD2 DNAI2 CFAP58	2.23e-05	188	199	7	e3e71c0f2e374330620cb4d27638953ffa9f5298
ToppCell	facs-Trachea-nan-3m-Mesenchymal-smooth_muscle_cell_of_trachea\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	XIRP1 DAG1 SORT1 ERFE ADAMTS20 SORBS2 ZDBF2	2.23e-05	188	199	7	794fc1d9a726945c42f7eac221eed938309b47a9
ToppCell	LPS_only-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SGSM1 THSD1 SORT1 CASKIN2 RGS6 EGFLAM MYOM2	2.31e-05	189	199	7	e82211b9dc7540e7a183be2cbcfae39fdf503949
ToppCell	droplet-Lung-18m-Epithelial-airway_epithelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYCBPAP WDR93 MDH1B DNAH5 DNAH1 DNAI2 CFAP58	2.31e-05	189	199	7	fe958fdf9963c2dfe270f67f0da36b3264d0017c
ToppCell	facs-Brain_Myeloid-Striatum-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SNX13 STAB1 ABCG1 P4HA1 TRAM1 EIF4G2 EDEM1	2.31e-05	189	199	7	875df61ee48baa5142ba4d2427bdec1c53e5a828
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	XIRP1 PSME4 USP13 SORBS2 ARHGEF12 DIP2C MYOM2	2.31e-05	189	199	7	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LRP1B TFCP2L1 EHF ASTN2 COL14A1 MYOF RGS6	2.39e-05	190	199	7	bf4511395fa97efd1c1cd17cc9bebb0271ee7f0e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LRP1B TFCP2L1 EHF ASTN2 COL14A1 MYOF RGS6	2.39e-05	190	199	7	b6b8964b4910083499681b5fdf554e127b6a4c4e
ToppCell	ASK454-Epithelial-Ciliated\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	MDH1B DNAH5 DYNC2I1 CFAP210 DNAI2 CFAP58 ANO3	2.39e-05	190	199	7	5cea6480f08253d7adf484e511d3fdfa96641268
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TFCP2L1 EHF ASTN2 COL14A1 DNAH5 MYOF EPB41L1	2.47e-05	191	199	7	5a67ff17fb4b9eff641176dff07830c9cd73754e
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TFCP2L1 EHF ASTN2 COL14A1 DNAH5 MYOF EPB41L1	2.47e-05	191	199	7	55ab2854a02cdcfc395e49870ccb7290b5e5471d
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_adventitial_fibro_(10)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	KCNH7 ADGRB2 SORBS2 COL12A1 MYOF RGS6 EGFLAM	2.64e-05	193	199	7	cd45118ced91b10baed3b1068d4673ec99824b86
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LRP1B GRAMD1B TFCP2L1 ASTN2 TRHDE PCLO EPB41L1	2.64e-05	193	199	7	82e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DSCAML1 TFCP2L1 ASTN2 DNAH5 TRHDE MYOF EPB41L1	2.73e-05	194	199	7	e577d9e88390b36b5a09b97fe1026089892275a3
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	LRP1B DSCAML1 TFCP2L1 ASTN2 TRHDE PCLO EPB41L1	2.82e-05	195	199	7	6477e6e7be5bd8eb99119a12ae16334ccddecd43
ToppCell	COVID-19-kidney-TAL\|kidney / Disease (COVID-19 only), tissue and cell type	LRP1B TFCP2L1 EHF DNAH5 NOS1 MYOF EPB41L1	2.91e-05	196	199	7	04f5eb206ed3016a737609a3ebac0c1fcabb94ef
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYCBPAP WDR93 MDH1B DNAH5 DYNC2H1 DYNC2I1 CFAP210	3.01e-05	197	199	7	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	VPS13C IRF7 YTHDC1 JMJD6 HERC6 UTRN SMAD7	3.11e-05	198	199	7	44417089b62056269cac38d3134ff209c05b7007
ToppCell	droplet-Limb_Muscle-MUSCLE-1m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NUMBL P3H1 SEMA3B COL14A1 POFUT2 HSPG2 COL12A1	3.11e-05	198	199	7	1b90d632e59c3c47b936e829cceeb0334f05f34f
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	VPS13C IRF7 YTHDC1 JMJD6 HERC6 UTRN SMAD7	3.11e-05	198	199	7	28ef3fc4c17dcb765537b75917f7db78baa522db
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_dendritic-CD141-positive_myeloid_dendritic_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DSCAML1 SEMA3A EHF RGS6 TVP23A ANO3	3.11e-05	134	199	6	0b1bb6fee8a2d8c27bca6d9cac6b47e85073dbf7
ToppCell	(09)_Interm._secr.>cil.-(2)_GFP_FOXI1\|(09)_Interm._secr.>cil. / shred by cell type by condition	VPS13C NSRP1 TFCP2L1 DNAH5 DYNC2I1 TRAM1 SCAF11	3.21e-05	199	199	7	fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell	Bronchus_Control_(B.)-Stromal-TX-Smooth_muscle-2\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	RXRG COL14A1 DYNC1I1 PCDHB7 RGS6 SUSD2 EGFLAM	3.21e-05	199	199	7	2c5ad62919c64ea0242e0984bb9932d2d975f4e3
ToppCell	ASK452-Epithelial-Type_1\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	SEMA3B UTRN COL12A1 SLC6A4 FADS3 SUSD2 SMAD7	3.21e-05	199	199	7	48cafe44951908d03f3c6f3e185e9cbb86fb5b3b
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	GALNT3 SNX30 BMP3 EHF AP1G2 CLNK P4HA1	3.31e-05	200	199	7	e8db082aa4d0597500e4f16a5c0ea3e62c6c59ae
ToppCell	control\|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	PLXNB2 EHF SORBS2 PCLO ARHGEF12 MYOF EPB41L1	3.31e-05	200	199	7	97f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCell	Control_saline-Endothelial-Endothelial-Activated_Alv_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	IRF7 THSD1 MYCBPAP CASKIN2 HERC6 ARHGEF12 EGFLAM	3.31e-05	200	199	7	be55cef682ba87250dad97689332c8820b3a7420
ToppCell	COVID-19-COVID-19_Mild\|COVID-19 / Disease, condition lineage and cell class	VPS13C IRF7 PLXNB2 TMEM259 UTRN ANKRD13D SMAD7	3.31e-05	200	199	7	62c25042086f1afd1102e0720e933c2e476468fd
ToppCell	NS-control\|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PLXNB2 EHF SORBS2 PCLO ARHGEF12 MYOF EPB41L1	3.31e-05	200	199	7	ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	EPHB6 ERFE NPTX1 COL12A1 DNAH1 ANO3	6.53e-05	153	199	6	b37a1ecad389d2848b8ca4d287823e8048207420
ToppCell	mild_COVID-19_(asymptomatic)-MAIT\|World / disease group, cell group and cell class (v2)	HERC6 DYNC2H1 ZDBF2 CDH24 DUSP16 MAST1	6.53e-05	153	199	6	2b4c69f6db17927d6506a645ac058133e60b0103
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MDH1B DNAH5 DUOX2 CFAP210 DNAH1 CFAP58	7.02e-05	155	199	6	5f1e2195a6b831e1b636f5cc3a282ca423721822
ToppCell	LPS-IL1RA+antiTNF-Epithelial_airway-Ciliated_cells-Ciliated\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MDH1B DNAH5 DUOX2 CFAP210 DNAH1 CFAP58	7.02e-05	155	199	6	0944429459f642a1bcc56edc1ec28aaecde3e2dc
ToppCell	LA-12._Cytoplasmic_Cardiomyocyte_II\|World / Chamber and Cluster_Paper	BMP8B EHF PCDHB7 CRYBB1 RPL15	8.22e-05	99	199	5	aed68765f60e54b7e2406c5f09fa744fcd844354
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO7B LRP1B DSCAML1 SEMA3A TRHDE COL12A1	8.36e-05	160	199	6	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	RV-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	UTRN ARHGEF25 CDH24 RGS6 SUSD2 EGFLAM	8.36e-05	160	199	6	29c9b4770d0e73d59cffc7937b179484c76b6dcc
ToppCell	PND07-28-samps-Myeloid-Macrophage-macrophage-B\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	GALNT3 SORT1 PPT2 SNX10 SLC6A4 ABCG1	8.36e-05	160	199	6	694bf1f1952bd8ab444819f533da24fa2b73f701
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO7B LRP1B DSCAML1 SEMA3A TRHDE COL12A1	8.36e-05	160	199	6	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	Adult-Mesenchymal-myofibroblast_cell-D175\|Adult / Lineage, Cell type, age group and donor	NUMBL RXRG COL14A1 POFUT2 EGFLAM ANO3	8.66e-05	161	199	6	048b7dc00746987a24bf870d4d278c4183eb04a2
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ZNF585A MYO7B CLIP2 ARHGEF12 ZC2HC1A DUSP16	8.66e-05	161	199	6	22fea192cd5f6d3544533d8b10e1d74dfedf0f05
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-proliferative_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SETSIP COL14A1 BMP8A ARHGEF25 STKLD1 ANO3	8.96e-05	162	199	6	bfaeff19bb56598fdc8c82be71d51787cf13928f
ToppCell	Frontal_cortex\|World / BrainAtlas - Mouse McCarroll V32	EPHB6 KCNH7 ERFE BMP3 NPTX1 COL12A1	9.58e-05	164	199	6	e09291711abf8680e78170328313719092b0142f
ToppCell	facs-Trachea-nan-18m-Epithelial-mucus_secreting_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF585A GALNT3 GIGYF1 TFCP2L1 NPTX1 CDH24	9.91e-05	165	199	6	7e7643834ed483aec04f513cca38d6367fda9ff8
ToppCell	LV-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	SORT1 COL14A1 UTRN SORBS2 RGS6 EGFLAM	9.91e-05	165	199	6	f37fd95adc95d7753cf6e55ae819976513c7ec77
ToppCell	LA-12._Cytoplasmic_Cardiomyocyte_II\|LA / Chamber and Cluster_Paper	BMP8B EHF PCDHB7 CRYBB1 RPL15	9.92e-05	103	199	5	e457f25e65a62c94685b15cd73fd3278fb94bf9c
ToppCell	droplet-Marrow-nan-21m-Lymphocytic-plasma_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL14A1 MYOF ABCG1 RASA4 MAST1 EPB41L1	1.02e-04	166	199	6	91eeb48680dd07ae4115afacdc0a8f6fa18885e5
ToppCell	Tuft-tuft-1\|World / Class top	KCNH7 ADGRB2 SORT1 SEC23B PML USP13	1.09e-04	168	199	6	8ddc2ec483ed2c6c0fb2ae521c6861ceb6d32e34
ToppCell	PND07-28-samps-Epithelial-Epithelial-non_alveolar-Ciliated_cell_of_lung_parenchyma\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	MYCBPAP WDR93 DNAH5 DNAH1 DNAI2 CFAP58	1.32e-04	174	199	6	f41d05a3703d7092bd3c4a97c15ae13069aaa4ad
ToppCell	metastatic_Lymph_Node-Endothelial_cells-Lymphatic_ECs\|metastatic_Lymph_Node / Location, Cell class and cell subclass	THSD1 SEMA3A NOS2 DYNC1I1 HSPG2 PCDHB7	1.32e-04	174	199	6	d551bc29afef071adf4c9bb80345352ec33441d8
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ERFE COL14A1 COL12A1 FADS3 RGS6 MYOM2	1.32e-04	174	199	6	015d3742d3d79a57413a333f00ef2d380a9848dd
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)\|Adult / Lineage, Cell type, age group and donor	KCNH7 CLNK DYNC1I1 NPTX1 CDH24 ASXL3	1.37e-04	175	199	6	4db1a3c284488b3f6de7568363f176d74e2a4587
ToppCell	Adult-Epithelial-lung_neuroendocrine_cell_(PNEC)-D231\|Adult / Lineage, Cell type, age group and donor	KCNH7 CLNK DYNC1I1 NPTX1 CDH24 ASXL3	1.37e-04	175	199	6	8d9f44a2633b71fb4d2b4a7d9530f954e07c4a18
ToppCell	facs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	THSD1 STAB1 SEMA3A CASKIN2 UTRN DUOX2	1.41e-04	176	199	6	460cb302c5b3d609c65b924e1d4e8ea057a68485
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RPS6KA2 THSD1 STAB1 SEMA3A UTRN SHC1	1.45e-04	177	199	6	227d4f423b00be2e0c5797e2c5275d342e69a0f4
ToppCell	metastatic_Lymph_Node-Endothelial_cells\|metastatic_Lymph_Node / Location, Cell class and cell subclass	THSD1 SEMA3A NOS2 HSPG2 PCDHB7 ASXL3	1.45e-04	177	199	6	71bf5d4bc67bda37a0499e5ec01af7dd5254041d
ToppCell	facs-Trachea-3m-Epithelial-airway_epithelial-tracheobronchial_ciliated_cell-ciliated_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MYCBPAP WDR93 DNAH5 SERPINA12 DNAI2 CFAP58	1.45e-04	177	199	6	3cfde67b93f3986312f5e74e42504214d966e7dc
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-lymphatic_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RPS6KA2 THSD1 STAB1 SEMA3A UTRN SHC1	1.45e-04	177	199	6	66ffa279147961080c104242a08b176e301d80e3
Drug	Naproxen [22204-53-1]; Up 200; 17.4uM; PC3; HT_HG-U133A	DAG1 THSD1 STAB1 SEMA3B HERC6 PML ARHGEF12 MYOF ABCG1 FADS3 SMAD7	1.18e-06	198	195	11	6358_UP
Drug	Fenoprofen calcium salt dihydrate [53746-45-5]; Down 200; 7.2uM; MCF7; HT_HG-U133A	PHF20 DAG1 SNX13 SORT1 PSME4 TMEM259 UTRN PCLO CHD1L COA1	7.09e-06	194	195	10	4736_DN
Drug	Levopropoxyphene napsylate [5714-90-9]; Up 200; 7.4uM; MCF7; HT_HG-U133A	RPS6KA2 TMEM259 SUPT6H ASTN2 MMP3 PLD2 PML HSPG2 FADS3 COA1	8.48e-06	198	195	10	5503_UP
Drug	Sulfamethoxypyridazine [80-35-3]; Down 200; 14.2uM; MCF7; HT_HG-U133A	PHF20 THSD1 SNX13 SORT1 PER3 UTRN WDR62 YTHDC2 ORC5 MYOF	8.48e-06	198	195	10	4733_DN
Disease	sudden infant death syndrome (implicated_via_orthology)	SLC6A4 VHLL	1.21e-04	3	188	2	DOID:9007 (implicated_via_orthology)
Disease	X-24544 measurement	UGT3A1 UGT3A2	2.40e-04	4	188	2	EFO_0800892
Disease	alkaline phosphatase measurement	GALNT3 NUMBL DCT SNX13 DNAJC12 BMP8A UTRN HSPG2 ATG16L1 NPHP3 FADS3 RGS6 STKLD1 EDEM1 FRMD5 SMAD7 KLHL17	2.87e-04	1015	188	17	EFO_0004533
Disease	Duchenne muscular dystrophy (is_marker_for)	DAG1 NOS1	3.99e-04	5	188	2	DOID:11723 (is_marker_for)
Disease	3-methyl-2-oxovalerate measurement	ASTN2 SORBS2	3.99e-04	5	188	2	EFO_0021021
Disease	Short rib-polydactyly syndrome, Verma-Naumoff type	DYNC2H1 DYNC2I1	3.99e-04	5	188	2	C0432197
Disease	adverse effect, response to xenobiotic stimulus	LRP1B ASTN2 COL14A1 DPP10	5.52e-04	59	188	4	EFO_0009658, GO_0009410
Disease	parenchymal hematoma, response to recombinant tissue-plasminogen activator	DSCAML1 SEMA3A	5.96e-04	6	188	2	EFO_0020101, EFO_0600080
Disease	lissencephaly (implicated_via_orthology)	DAG1 NOS1 NOS2	6.65e-04	27	188	3	DOID:0050453 (implicated_via_orthology)
Disease	primary biliary cholangitis (biomarker_via_orthology)	DAG1 MMP3 NOS2	7.42e-04	28	188	3	DOID:12236 (biomarker_via_orthology)
Disease	heel bone mineral density, urate measurement	ASTN2 UTRN CHD1L INTS13 YY1AP1 MYOM2	1.14e-03	182	188	6	EFO_0004531, EFO_0009270
Disease	Parkinsonism (biomarker_via_orthology)	MMP3 NOS1 SLC6A4	1.32e-03	34	188	3	DOID:0080855 (biomarker_via_orthology)
Disease	parental longevity	ADGRB2 PLXNB2 LRP1B NAA25 DPP10 PCLO SLC6A4 ABCG1 MYOM2 SMAD7	1.33e-03	494	188	10	EFO_0007796
Disease	Hypermetropia, Myopia	RPS6KA2 DSCAML1 GRAMD1B BMP3 DYNC2I1 POLR3B	1.38e-03	189	188	6	HP_0000540, HP_0000545
Disease	Oxidative Phosphorylation Deficiencies	NOS2 FOXRED1	1.41e-03	9	188	2	C0949856
Disease	Mitochondrial Respiratory Chain Deficiencies	NOS2 FOXRED1	1.41e-03	9	188	2	C0949857
Disease	Electron Transport Chain Deficiencies, Mitochondrial	NOS2 FOXRED1	1.41e-03	9	188	2	C0949855
Disease	renin measurement, hypertension	SGSM1 FAM114A2	1.41e-03	9	188	2	EFO_0000537, EFO_0010616
Disease	Subarachnoid Hemorrhage	THSD1 NOS2	1.41e-03	9	188	2	C0038525
Disease	Primary ciliary dyskinesia	DNAH5 DNAH1 DNAI2	1.56e-03	36	188	3	cv:C0008780
Disease	Uterine leiomyoma, estrogen-receptor negative breast cancer	MCM8 DDX10	1.76e-03	10	188	2	EFO_1000650, HP_0000131
Disease	Allodynia	MMP3 NOS1 NOS2 CSK	2.07e-03	84	188	4	C0458247
Disease	Mechanical Allodynia	MMP3 NOS1 NOS2 CSK	2.07e-03	84	188	4	C2936719
Disease	Hyperalgesia, Secondary	MMP3 NOS1 NOS2 CSK	2.07e-03	84	188	4	C0751212
Disease	Hyperalgesia, Primary	MMP3 NOS1 NOS2 CSK	2.07e-03	84	188	4	C0751211
Disease	Hyperalgesia, Thermal	MMP3 NOS1 NOS2 CSK	2.07e-03	84	188	4	C0751214
Disease	Tactile Allodynia	MMP3 NOS1 NOS2 CSK	2.07e-03	84	188	4	C0751213
Disease	Hyperalgesia	MMP3 NOS1 NOS2 CSK	2.07e-03	84	188	4	C0020429
Disease	Jeune thoracic dystrophy	DYNC2H1 DYNC2I1	2.14e-03	11	188	2	C0265275
Disease	retinopathy of prematurity (biomarker_via_orthology)	NOS1 NOS2	2.56e-03	12	188	2	DOID:13025 (biomarker_via_orthology)
Disease	age at assessment, pelvic organ prolapse	DUSP12 SACS SORBS2	2.60e-03	43	188	3	EFO_0004710, EFO_0008007
Disease	left ventricular systolic function measurement	LRP1B TTR SNX13	2.78e-03	44	188	3	EFO_0008206
Disease	matrix metalloproteinase measurement	MMP3 DYNC2H1	3.01e-03	13	188	2	EFO_0004744
Disease	Short Rib-Polydactyly Syndrome	DYNC2H1 DYNC2I1	3.01e-03	13	188	2	C0036996
Disease	cortisol measurement, response to corticosteroid, response to synacthen	LRP1B NOS1	3.01e-03	13	188	2	EFO_0005843, EFO_0009175, GO_0031960
Disease	multisite chronic pain	ADGRB2 ASTN2 UTRN DYNC1I1	3.24e-03	95	188	4	EFO_0010100
Disease	Primary Ciliary Dyskinesia	DNAH5 DNAH1 DNAI2	3.36e-03	47	188	3	C4551720
Disease	abdominal aortic aneurysm (biomarker_via_orthology)	MMP3 NOS2	3.49e-03	14	188	2	DOID:7693 (biomarker_via_orthology)
Disease	Kartagener syndrome (implicated_via_orthology)	DNAH5 DNAI2	3.49e-03	14	188	2	DOID:0050144 (implicated_via_orthology)
Disease	Saldino-Noonan Syndrome	DYNC2H1 DYNC2I1	3.49e-03	14	188	2	C0036069
Disease	Majewski Syndrome	DYNC2H1 DYNC2I1	3.49e-03	14	188	2	C0024507
Disease	Alzheimer disease, dementia, family history of Alzheimer’s disease	POLR3B DNAI2 EGFLAM	3.57e-03	48	188	3	EFO_0009268, MONDO_0001627, MONDO_0004975
Disease	developmental disorder of mental health (implicated_via_orthology)	GIGYF1 PLXNB2 GABRR3	3.78e-03	49	188	3	DOID:0060037 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	XIRP1 DDX10 SEMA3A NAA25 PER3 JMJD6 MTMR3 ASTN2 MMP3 PLD2 NOS2 DYNC2H1 AQP8 DIP2C UQCC1	3.81e-03	1074	188	15	C0006142
Disease	Down syndrome (implicated_via_orthology)	DSCAML1 POFUT2	4.01e-03	15	188	2	DOID:14250 (implicated_via_orthology)
Disease	hepatic encephalopathy (biomarker_via_orthology)	NOS1 NOS2	4.01e-03	15	188	2	DOID:13413 (biomarker_via_orthology)
Disease	level of Phosphatidylcholine (16:0_16:0) in blood serum	SNX13 PPT2	4.01e-03	15	188	2	OBA_2045067
Disease	Abnormality of refraction	DSCAML1 SEMA3A GRAMD1B BMP3 MTMR3 ADAMTS20 UTRN SEC23B DYNC1I1 PCLO TRAM1	4.09e-03	673	188	11	HP_0000539
Disease	idiopathic osteonecrosis of the femoral head	ASTN2 CLNK ABCG1	4.47e-03	52	188	3	EFO_1001930
Disease	cutaneous psoriasis measurement, psoriasis	NOS2 RGS6	4.57e-03	16	188	2	EFO_0000676, EFO_0007773
Disease	transferrin saturation measurement	ERFE DUOX2	4.57e-03	16	188	2	EFO_0006333
Disease	Seasonal Affective Disorder	PER3 SLC6A4	4.57e-03	16	188	2	C0085159
Disease	hepatocellular carcinoma (biomarker_via_orthology)	TTR NOS2 SHC1 CSK	5.11e-03	108	188	4	DOID:684 (biomarker_via_orthology)
Disease	copine-1 measurement	UQCC1 EPB41L1	5.16e-03	17	188	2	EFO_0008102
Disease	spinal stenosis	ASTN2 DYNC1I1	5.16e-03	17	188	2	EFO_0007490
Disease	estradiol measurement	MCM8 UGT3A1 EHF UGT3A2	5.45e-03	110	188	4	EFO_0004697
Disease	Glioblastoma Multiforme	EPHB6 POLK PML STKLD1	5.63e-03	111	188	4	C1621958
Disease	matrix metalloproteinase 12 measurement	MMP3 DYNC2H1	5.78e-03	18	188	2	EFO_0010590
Disease	Uterine leiomyoma, estrogen-receptor positive breast cancer	MCM8 ASTN2	5.78e-03	18	188	2	EFO_1000649, HP_0000131
Disease	frontal pole volume measurement	NOS1 DIP2C	5.78e-03	18	188	2	EFO_0010304
Disease	obsolete_red blood cell distribution width	DUSP12 FAM114A2 BCKDHA SNX13 ERFE TMEM259 USP4 BMP8A POLK SEC23B DUOX2 CDH24 LOXHD1 MAST1 STKLD1 FRMD5 SMAD7	5.80e-03	1347	188	17	EFO_0005192
Disease	Withdrawal Symptoms	PER3 NOS2 SLC6A4	6.07e-03	58	188	3	C0087169
Disease	Drug Withdrawal Symptoms	PER3 NOS2 SLC6A4	6.07e-03	58	188	3	C0086189
Disease	Substance Withdrawal Syndrome	PER3 NOS2 SLC6A4	6.07e-03	58	188	3	C0038587

Protein segments in the cluster

Peptide	Gene	Start	Entry
SEEKDFLPWHAASRA	TRHDE	746	Q9UKU6
WVRHSEDRLFLPKEV	ADGRB2	751	O60241
DRKWEFSVPFHQALN	ARMT1	376	Q9H993
LRENSWVKDPFAFRH	FAM200B	531	P0CF97
IWDAELPRAKRNHSY	DIAPH2-AS1	36	Q14236
DFLKVPRIHWDLSTE	ADCK1	251	Q86TW2
PKWDSHIRAALSIER	BMP3	271	P12645
IRPDFDKKWTSIHER	EGFLAM	181	Q63HQ2
DPDWLAQLFIKHERR	ARHGEF25	231	Q86VW2
VQRFKATLWLSEEHP	ANKRD13D	356	Q6ZTN6
FLWHRPSEEVKQTKR	ABCG1	366	P45844
RAADFPRWKRHISEQ	ATG16L1	6	Q676U5
LLAAERFAPTKRWHI	AP1G2	406	O75843
RLRDKQWHLEGSFPV	CRYBB1	231	P53674
HLRFRWSKDAPSELL	DNAJC12	176	Q9UKB3
PERDLSREVHKAEWR	CLIP2	926	Q9UDT6
PWFHGKITREQAERL	CSK	81	P41240
ALAKAVSPEERFWNA	AQP8	126	O94778
GARPEHAVAWDKDRQ	FAM187A	291	A6NFU0
RDPQEIKRAATHLSW	DNAI2	156	Q9GZS0
HWFDPKTRDIRKHID	CYB5D1	71	Q6P9G0
RKDFVLHDPEARWIN	DPP10	76	Q8N608
IRPDVRQDESQKWRH	ATG2B	2061	Q96BY7
VWRSEDELGPRKAHL	ASTN2	1251	O75129
RRFSDIIFHPWKKEE	GRAMD1B	406	Q3KR37
TWAEAARLALEKHPN	ASXL3	11	Q9C0F0
LFITRSWEVDFHPRQ	ADAMTS20	16	P59510
SWEVDFHPRQEALVR	ADAMTS20	21	P59510
EHQRSKSPRDPDANW	AFF4	206	Q9UHB7
EKSVQEDWQHFPRYR	ARHGEF12	1271	Q9NZN5
NKLFDRWRLEECHPS	ANO3	671	Q9BYT9
SRPHQWQADEDAVRK	NUMBL	61	Q9Y6R0
WFRLQPDQSKSRRHD	RASA4	231	O43374
WKRHEQEDKPRARDQ	NSRP1	356	Q9H0G5
SRRFLVHDSFWALPE	HSPG2	586	P98160
WFRLQPDQSKSRRHD	RASA4B	231	C9J798
ILDSQERAFWDVHRP	RGS6	191	P49758
AIALWFTLDPRHSER	P3H1	671	Q32P28
ERAKDQLEKHTRYWP	INTS13	446	Q9NVM9
LAHFNIWDRKLTPGE	NPTX1	376	Q15818
VFPQRSDGKHDFRVW	NOS2	246	P35228
PNSKLIHRDRDWERE	EPB41L1	521	Q9H4G0
IVAQWDRFATPKHRQ	ADIPOR1	251	Q96A54
ARPELKDSLDWTRHN	JMJD6	16	Q6NYC1
WPNGLTVDHFEKRIV	LRP1B	1426	Q9NZR2
NQNRDPREWKAHFLE	MAGED4	596	Q96JG8
PREWKAHFLEAVDDA	MAGED4	601	Q96JG8
PRKEHARSDSENWRS	GIGYF1	186	O75420
NFSGKWREREHRPDL	MCM8	26	Q9UJA3
DSLWHRSDSAPRNKI	MFF	171	Q9GZY8
DHSSPKRQWDRLYPD	KCNH7	236	Q9NS40
EEELENPLNVHRWRK	CFAP58	701	Q5T655
NPLNVHRWRKLEASD	CFAP58	706	Q5T655
HRWRKLEASDPNAYE	CFAP58	711	Q5T655
DRHFWRKSLRKLEPE	MMP3	311	P08254
REDRFIPKRELAWHV	LOXHD1	1881	Q8IVV2
AVPHNDEWTRFARTL	DYNC1I1	611	O14576
RPELKNHIDRVDAWV	DAG1	496	Q14118
DIQHLKRRWAAPEVD	DYNC2I1	1031	Q8WVS4
AQRLARQHPDWEDEE	DUOX2	266	Q9NRD8
IHTAAPLDREARAWH	CDH24	431	Q86UP0
HAWRELDKDAPRADE	ESF1	331	Q9H501
EAWKEPAEDCLFLRH	FAM90A27P	131	A6NNH2
HLRREETDWFDKPRE	PCLO	4436	Q9Y6V0
RWSPEFHLQRKLADS	PER3	26	P56645
TRKAECPRAEEASHW	PLXNB2	496	O15031
GIRWEVEPRHEQKLF	EEF2KMT	301	Q96G04
ERAHSVDPRDAWMLF	ERFE	71	Q4G0M1
RFSIHWDQNDVDLIP	HERC6	826	Q8IVU3
EQRRVDPDVAQHWAK	NKIRAS2	126	Q9NYR9
ADQLWAQERKHPTRL	KIF24	1216	Q5T7B8
AQERKHPTRLGWQEF	KIF24	1221	Q5T7B8
DKERQWVDDFPLHRS	KRIT1	281	O00522
WIPDTFFRNSKRTHE	GABRE	151	P78334
RVPWKHFARKDLSEA	IRF7	41	Q92985
PAWHKSIVSFRQLRE	TWNK	361	Q96RR1
LKERWNRRHEPAFDK	GNMT	96	Q14749
NRRHEPAFDKWVIEE	GNMT	101	Q14749
TVELREHHWVPRKAF	EIF4G2	301	P78344
VRALKDFWNLHDPTA	CASKIN2	286	Q8WXE0
DWTGLLRQKAEFIPH	MAST1	651	Q9Y2H9
IFPQRTDGKHDFRVW	NOS1	466	P29475
EWDKPRIIRFHDIIS	P4HA1	331	P13674
ERDHPNATVWRKNFL	PPT2	201	Q9UMR5
LWVRDINDHAPVFLD	PCDHB7	121	Q9Y5E2
AWNQAELSRLKREHP	PDP2	311	Q9P2J9
LAEADWHKTDLAQRP	PDP2	431	Q9P2J9
RFVDPDKQRHWLEFT	FRMD5	61	Q7Z6J6
PDKVHRDFRLWLTSL	DNAH1	3751	Q9P2D7
LEFTKEVFHWARESP	DYNC2H1	2206	Q8NCM8
AFESWNAHQPKLLER	CEFIP	276	Q711Q0
FDHRLTRKIWVPDIF	GABRR3	131	A8MPY1
SWVKHDVDARRQHVP	KLHL17	261	Q6TDP4
DPRTEWQLNAHRDKK	COL12A1	1246	Q99715
HQVEELRLSDWFHPR	GLT6D1	26	Q7Z4J2
PHVWFERSEVKDRHL	GPAT4	286	Q86UL3
WEKDTVSIIPEHRFF	DSCAML1	161	Q8TD84
QQVLLRPSFWEARKH	DYTN	41	A2CJ06
PEERQRIFLTWKKHD	CPHXL2	81	A0A1W2PPK0
PRIEWHLNAFSTKDE	COL14A1	206	Q05707
SFGWESLPDHEKQRR	GALNT3	336	Q14435
RLTFQWHSVPKQERD	GALNT4	281	Q8N4A0
KHNPRGTHLWEFIRD	EHF	201	Q9NZC4
QKPSDRADSRRSWHE	DUSP16	601	Q9BY84
RSWHEESPFEKQFKR	DUSP16	611	Q9BY84
FPWSVLVVDEAHRLK	CHD1L	166	Q86WJ1
ELGRPLWRQAEAEHK	COMTD1	141	Q86VU5
DFFQDKVWPHLALRV	FOXRED1	381	Q96CU9
QEPHWKEFRFDLTQI	BMP8A	121	Q7Z5Y6
RDWFPHIKDANNDTA	DIP2C	481	Q9Y2E4
VDEHLRELPWKEFFS	EDEM1	586	Q92611
PEKLARARNTAHEWI	FAM114A2	326	Q9NRY5
DFRIHKITQRPEVWE	MDH1B	31	Q5I0G3
NCLEHVRDKWPREGI	TMEM259	96	Q4ZIN3
SDESTLEHFKRWLQP	CCDC32	131	Q9BV29
IRRKENGWYDEEHPL	CLPB	361	Q9H078
HNRKKARWDTLEPLD	DDX10	841	Q13206
CHDLAPTWRDFAKEV	DNAJC10	161	Q8IXB1
QEPHWKEFRFDLTQI	BMP8B	121	P34820
HDQPGDKWLVIERRV	FADS3	31	Q9Y5Q0
RWITPAFQIHKNRVD	DUSP12	311	Q9UNI6
QKRHELELSWFPDTL	SCAF11	226	Q99590
PEDWHGIQEIARSRK	SACS	166	Q9NZJ4
DPRQHPVDRIFDDKW	SACS	2566	Q9NZJ4
PFQRWHLDEVFLELK	COA1	111	Q9GZY4
RWPKDALVAVSEHFL	DNAH5	3116	Q8TE73
RCSDPSLNEKWQEHR	MTMR3	631	Q13615
VNYWDKQDHPISRLR	BCKDHA	351	P12694
ARDRLKNWYPAHIED	PHF20	21	Q9BVI0
DQFILRVSPDLEWHA	ISL2	36	Q96A47
RRADAGEKPKAFIHW	QARS1	666	P47897
PDVDNHWALRDFAAR	TAF6	321	P49848
VADSVKRFRDAFWPN	SNX13	841	Q9Y5W8
NAVLHRHKPDLFSWD	UTRN	186	P46939
RWTHLRKPENSECDA	SORT1	436	Q99523
HLSDDFREDPVAWAR	SUSD2	276	Q9UGT4
LNVWPERHFKIDASG	TMC3	901	Q7Z5M5
KDFIWGHRQDVPSLE	POFUT2	296	Q9Y2G5
EEFPRWLEKLSARHQ	NPHP3	601	Q7Z494
SERDTRKLWRNIEPH	ORC5	246	O43913
QWFLKHEARPLAELR	PML	156	P29590
DTWQKDRARRPHFDQ	EPHB6	896	O15197
LPEWFVQEEKQHRIR	FTSJ3	701	Q8IY81
SRKRQHEEPESFFTW	SETSIP	201	P0DME0
RRSAQWLDQEEAPKH	SETMAR	506	Q53H47
SRKRQHEEPESFFTW	SET	191	Q01105
SHPWLFRDARTHDKL	VHLL	96	Q6RSH7
LEKHAQGRPRFDWLQ	WIZ	126	O95785
IRTEQHDSRWLNDPK	SEMA3A	211	Q14563
KAPRQDVWERPHSEF	SRMS	216	Q9H3Y6
DVWERPHSEFALGRK	SRMS	221	Q9H3Y6
LWDPAKRASAFIQVH	TFCP2L1	156	Q9NZI6
HDWDPPDRKVDTRKF	SORBS2	191	O94875
PIRSWHDIEKDNARF	SEC23B	311	Q15437
RARWKHEFDPNVTKE	SERPINA12	211	Q8IW75
PHDEWKRIQDSLDRL	CFAP210	51	Q0VFZ6
PKRSDRKDVQHNEWY	CLNK	296	Q7Z7G1
LPHFTKRRTAWREEE	SUPT6H	811	Q7KZ85
PAAIEHTIQWARDKF	UBA6	631	A0AVT1
VIRWFSPEDHQKRIK	UGT3A1	76	Q6NUS8
KVFRWPDLRHSSEVK	SMAD7	161	O15105
LAAADHPLSRDNKWV	TTLL8	376	A6PVC2
RPDAVVAKEAWENHR	USP4	426	Q13107
WAHRVRPLQDAAEDL	TRIM11	121	Q96F44
FDWLRSKLEESQPTH	SNX30	136	Q5VWJ9
AKWNIRAEEDPFRKS	STKLD1	186	Q8NE28
RTEPHDSRWLNEPKF	SEMA3B	211	Q13214
DPFHKAIRRNPDTQW	RPL15	136	P61313
ILRHAKAAEDSPYWV	WDR70	606	Q9NW82
EWPVFHVDLNRSAKA	THSD1	126	Q9NS62
KHLEERQNWPEDKRR	POLK	206	Q9UBT6
PEFERRNWVKIHFNR	ZDBF2	2071	Q9HCK1
DWRRQHQPDTFQDLK	MYCBPAP	461	Q8TBZ2
VEWAKRIPHFSDLTL	RXRG	281	P48443
PDRQAWLYHEDHRDK	STAB1	1776	Q9NY15
KNWNGHFRIRDTLPE	VPS13C	2721	Q709C8
DAATRKPIWRHEILD	POLR3B	796	Q9NW08
FWTDPSADELVQRHR	SGSM1	191	Q2NKQ1
WRTFFNRKCEDPRHL	UQCC1	231	Q9NVA1
DDRELWPRKFFHRTC	DCT	81	P40126
SCESRDPRKLHWLFE	PSME4	1431	Q14997
DWICRRELPFTKSAH	YTHDC1	446	Q96MU7
RDPRIQKEDFWHSYI	SNX10	16	Q9Y5X0
FSREEWRHLDPSQRN	ZNF585A	36	Q6P3V2
IEREEHRLPFWLKAS	YY1AP1	366	Q9H869
NGHRPAVRIWDVEEK	WDR62	131	O43379
KPSNWRRKHEEFIAT	ZC2HC1A	76	Q96GY0
KDLHPRDIDAFWLQR	SNRNP200	256	O75643
VEWIRKESLPFQFAH	YTHDC2	1371	Q9H6S0
RRWREHSAFQAPAVK	TRAM1	321	Q15629
NPEKEEEHWARLQRY	WDR93	661	Q6P2C0
SAEEIRKFWQNSEHP	SNAPC4	276	Q5SXM2
RRAVAWAQHEGKESP	STRCP1	1726	A6NGW2
HVFRKAADDTWEPFA	TTR	51	P02766
HWIFEARKVSPNSIA	TVP23A	101	A6NH52
VISWLAPEDHQREFK	UGT3A2	76	Q3SY77
LPSKKDRRSWVEQDH	ZSCAN29	221	Q8IWY8
LDEFPHVWAKRRERF	SLC6A4	451	P31645
QVLKSEDPRHRALAW	TTC22	236	Q5TAA0
EHWSFPQEVAERFLR	ZYG11A	66	Q6WRX3
YLKRPAHSDDWRLDI	PLD2	371	O14939
WRLDAIGEHERPAAK	XIRP1	101	Q702N8
EPWFHGKLSRREAEA	SHC1	486	P29353
NLERALDWIFSHPEF	USP13	756	Q92995
EIKRHPFFVTIDWNT	RPS6KA2	311	Q15349
RKEFFTPWHDSREDP	MYO7B	1286	Q6PIF6
KEHFWSIDQTEFRIP	MYOF	1866	Q9NZM1
RDLNVFFSWDPKDRD	NAA25	656	Q14CX7
RVRFWLQAEHLSPDA	MYOM2	1031	P54296
AVLDFTHPKARDWFQ	MYORG	431	Q6NSJ0