Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	HOXA4 HIVEP3 ZNF16 ZFHX3 HIVEP1 ZNF296 ZNF99 ZNF501 ZIC1	1.04e-04	1244	32	9	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	HOXA4 HIVEP3 ZNF16 ZFHX3 HIVEP1 ZNF296 ZNF99 ZNF501 ZIC1	1.23e-04	1271	32	9	GO:0000987
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	HOXA4 HIVEP3 ZNF16 ZFHX3 HIVEP1 ZNF296 ZNF99 ZNF501 ZIC1	3.48e-04	1459	32	9	GO:0000977
GeneOntologyCellularComponent	sperm fibrous sheath	TSGA10 AKAP4	1.75e-04	13	32	2	GO:0035686
GeneOntologyCellularComponent	sperm head-tail coupling apparatus	AKAP4 CNTLN	3.42e-04	18	32	2	GO:0120212
Domain	-	HIVEP3 ZNF16 ZFHX3 HIVEP1 ZNF296 ZNF99 ZNF501 ZXDB ZIC1	1.85e-06	679	33	9	3.30.160.60
Domain	zf-C2H2	HIVEP3 ZNF16 ZFHX3 HIVEP1 ZNF296 ZNF99 ZNF501 ZXDB ZIC1	2.19e-06	693	33	9	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	HIVEP3 ZNF16 ZFHX3 HIVEP1 ZNF296 ZNF99 ZNF501 ZXDB ZIC1	2.22e-06	694	33	9	IPR013087
Domain	ZF_CCHC_HIVEP	HIVEP3 HIVEP1	3.03e-06	2	33	2	PS51811
Domain	ZINC_FINGER_C2H2_2	HIVEP3 ZNF16 ZFHX3 HIVEP1 ZNF296 ZNF99 ZNF501 ZXDB ZIC1	5.47e-06	775	33	9	PS50157
Domain	ZINC_FINGER_C2H2_1	HIVEP3 ZNF16 ZFHX3 HIVEP1 ZNF296 ZNF99 ZNF501 ZXDB ZIC1	5.59e-06	777	33	9	PS00028
Domain	Znf_C2H2-like	HIVEP3 ZNF16 ZFHX3 HIVEP1 ZNF296 ZNF99 ZNF501 ZXDB ZIC1	6.80e-06	796	33	9	IPR015880
Domain	Znf_C2H2	HIVEP3 ZNF16 ZFHX3 HIVEP1 ZNF296 ZNF99 ZNF501 ZXDB ZIC1	7.45e-06	805	33	9	IPR007087
Domain	ZnF_C2H2	HIVEP3 ZNF16 ZFHX3 HIVEP1 ZNF296 ZNF99 ZNF501 ZXDB ZIC1	7.67e-06	808	33	9	SM00355
Domain	GPS	ADGRL2 ADGRG4	1.64e-03	34	33	2	SM00303
Domain	GPCR_2_secretin-like_CS	ADGRL2 ADGRG4	1.64e-03	34	33	2	IPR017983
Domain	GPS	ADGRL2 ADGRG4	1.74e-03	35	33	2	PF01825
Domain	GPS	ADGRL2 ADGRG4	1.84e-03	36	33	2	PS50221
Domain	GPS	ADGRL2 ADGRG4	1.94e-03	37	33	2	IPR000203
Domain	G_PROTEIN_RECEP_F2_1	ADGRL2 ADGRG4	2.26e-03	40	33	2	PS00649
Domain	G_PROTEIN_RECEP_F2_3	ADGRL2 ADGRG4	2.26e-03	40	33	2	PS50227
Domain	GPCR_2_extracellular_dom	ADGRL2 ADGRG4	2.26e-03	40	33	2	IPR001879
Domain	G_PROTEIN_RECEP_F2_2	ADGRL2 ADGRG4	3.52e-03	50	33	2	PS00650
Domain	7tm_2	ADGRL2 ADGRG4	3.52e-03	50	33	2	PF00002
Domain	GPCR_2-like	ADGRL2 ADGRG4	5.03e-03	60	33	2	IPR017981
Domain	GPCR_2_secretin-like	ADGRL2 ADGRG4	5.03e-03	60	33	2	IPR000832
Domain	G_PROTEIN_RECEP_F2_4	ADGRL2 ADGRG4	5.19e-03	61	33	2	PS50261
Pubmed	Down-regulation of TSGA10, AURKC, OIP5 and AKAP4 genes by Lactobacillus rhamnosus GG and Lactobacillus crispatus SJ-3C-US supernatants in HeLa cell line.	TSGA10 AKAP4	5.23e-06	4	33	2	30545223
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PIKFYVE HIVEP3 ARHGAP32 SACS DOP1A	9.59e-05	493	33	5	15368895
Pubmed	Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ARHGAP32 ADGRL2 SACS	1.22e-04	101	33	3	9872452
Pubmed	Ablation of Ezh2 in neural crest cells leads to aberrant enteric nervous system development in mice.	HOXA4 ZIC1	1.64e-04	20	33	2	30169530
Pubmed	A census of human transcription factors: function, expression and evolution.	HOXA4 HIVEP3 ZNF16 ZFHX3 HIVEP1 ZIC1	1.89e-04	908	33	6	19274049
Pubmed	Genome-wide association analyses identify variants in developmental genes associated with hypospadias.	HOXA4 ZFHX3	2.58e-04	25	33	2	25108383
Pubmed	The cellular and molecular landscape of hypothalamic patterning and differentiation from embryonic to late postnatal development.	ZFHX3 ZIC1	3.25e-04	28	33	2	32868762
Pubmed	The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.	ADGRL2 ADGRG4	3.49e-04	29	33	2	15203201
Pubmed	International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.	ADGRL2 ADGRG4	4.53e-04	33	33	2	25713288
Pubmed	Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.	ZFHX3 ZIC1	6.33e-04	39	33	2	19010793
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	HIVEP3 ZFHX3 HIVEP1 ZNF296 ZNF99	9.25e-04	808	33	5	20412781
Interaction	LHX2 interactions	ARHGAP32 ZFHX3 HIVEP1 DDX24 BCORL1	1.13e-05	183	33	5	int:LHX2
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	HIVEP3 ZNF16 ZFHX3 HIVEP1 ZNF296 ZNF99 ZNF501 ZXDB ZIC1	1.16e-07	718	23	9	28
Coexpression	DAZARD_RESPONSE_TO_UV_NHEK_DN	PIKFYVE PPIP5K2 ADGRL2 SACS DOP1A	3.47e-05	300	33	5	M8702
Coexpression	WEBER_METHYLATED_LCP_IN_SPERM_DN	TSGA10 TEX15	4.28e-05	8	33	2	M4762
ToppCell	BAL-Control-Lymphocyte-B-B_cell\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PIKFYVE HIVEP3 SACS ZNF501	1.15e-05	190	33	4	da7341a8a423e5fe4d8e733d8e50c10a3318ac1c
ToppCell	BAL-Control-Lymphocyte-B-B_cell-B_cell-B_activate-7\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PIKFYVE HIVEP3 SACS ZNF501	1.15e-05	190	33	4	682418a7a2096743112eae3790d40e7e600612c0
ToppCell	BAL-Control-Lymphocyte-B-B_cell-B_cell\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PIKFYVE HIVEP3 SACS ZNF501	1.15e-05	190	33	4	42312f7d79fe889397d32910b625793e2535cc26
Disease	juvenile polyposis syndrome (implicated_via_orthology)	HIVEP3 HIVEP1	8.27e-05	13	31	2	DOID:0050787 (implicated_via_orthology)
Disease	hypospadias	HOXA4 ZFHX3	7.73e-04	39	31	2	EFO_0004209
Disease	Alzheimer's disease (implicated_via_orthology)	HIVEP3 HIVEP1	1.64e-03	57	31	2	DOID:10652 (implicated_via_orthology)
Disease	mucocutaneous lymph node syndrome	CENPU ZFHX3	2.90e-03	76	31	2	EFO_0004246
Disease	eye color	HIVEP3 ARHGAP32	4.04e-03	90	31	2	EFO_0003949
Disease	Neurodevelopmental Disorders	HIVEP3 KMT5B	4.31e-03	93	31	2	C1535926
Disease	Hypermetropia	HIVEP3 DUSP10	5.25e-03	103	31	2	HP_0000540
Disease	aspartate aminotransferase measurement, serum alanine aminotransferase measurement, low density lipoprotein triglyceride measurement, body fat percentage, high density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement	HIVEP3 ZFHX3 HIVEP1	6.48e-03	364	31	3	EFO_0004612, EFO_0004696, EFO_0004735, EFO_0004736, EFO_0007800, EFO_0009946
Disease	lung disease severity measurement	ZFHX3 KMT5B	6.84e-03	118	31	2	EFO_0007744

Protein segments in the cluster

Peptide	Gene	Start	Entry
KKMKKNRDACKTSTH	CNTLN	1306	Q9NXG0
KMKSDPCKSLTSAEK	AKAP4	481	Q5JQC9
ITKSSKTMHPGCLKS	ADGRG4	1536	Q8IZF6
PSGKRKCKTKHMATV	BCORL1	1416	Q5H9F3
RTHSMKDKAGQKCKP	CENPU	26	Q71F23
ITLCKMVKHSNTLKP	ADGRL2	1011	O95490
NKDMKLENHKPCSSK	DOP1A	2431	Q5JWR5
PGKHSNKKVMRTKSS	CPXM2	101	Q8N436
KCHKSDTGMSKKKSR	KMT5B	601	Q4FZB7
AKKMTKCSKSHLPSQ	DUSP10	156	Q9Y6W6
SGEKKNKKSPLAMSH	KNOP1	111	Q1ED39
KTCGSTASMKVKHVK	ARHGAP32	91	A7KAX9
CTKNIAHKKMSSCIK	PIKFYVE	686	Q9Y2I7
AHKKMSSCIKNPKIL	PIKFYVE	691	Q9Y2I7
TGKDCPHMKEKSALK	ELMO2	611	Q96JJ3
MKLKDTKSRPKQSSC	DDX24	1	Q9GZR7
PRMTKSSLQKLCKQH	DNAAF1	86	Q8NEP3
PKSESMAKKQPACKT	KIAA1210	1546	Q9ULL0
AKLMKTCSSSNKKLP	SACS	1736	Q9NZJ4
KKDHKLPNTKMRSSN	HOXA4	271	Q00056
LSQKKTHMKCPKTSF	MAP3K19	716	Q56UN5
CFGMLPKSKTSKTHT	PTRH2	36	Q9Y3E5
SSMFTKCKIIHTGKK	ZNF99	241	A8MXY4
ISSCNKLFTSKHSMK	ZXDB	551	P98169
NLTKHMKSKAHSKKC	HIVEP3	1796	Q5T1R4
MKSKAHSKKCQETGV	HIVEP3	1801	Q5T1R4
EMMKSCKSPKSTTAH	TSGA10	81	Q9BZW7
ANPKKSCNKTFSTMH	ZIC1	236	Q15915
SSLKKHQKSHMSEKP	ZNF16	306	P17020
KSMHLIKNPVKTCDK	PPIP5K2	651	O43314
KKCLSRKSMASSVSK	TEX15	1101	Q9BXT5
LTKHMKSKAHSKKCV	HIVEP1	2131	P15822
KHGRVNMQKKPSKCS	ZNF501	11	Q96CX3
CKKTLSSFSNLKVHM	ZNF296	236	Q8WUU4
MMHSRNSCKTLKCPK	ZFHX3	661	Q15911