Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	organelle assembly	FLII PFN4 MDN1 ZMYND10 AP5Z1 LRRK2 ATG2B ULK4 TUBGCP2 CPLANE1 DCTN1 CEP97	2.98e-05	1138	54	12	GO:0070925
GeneOntologyBiologicalProcess	regulation of DNA stability	DDI2 DDI1	4.02e-05	4	54	2	GO:0097752
GeneOntologyBiologicalProcess	cytosolic transport	TANC2 AP5Z1 LRRK2 DCTN1 DOP1A	4.52e-05	150	54	5	GO:0016482
Domain	-	RSPH14 AP5Z1 LRRK2 TOGARAM2 ULK4 TTI1 IPO4 TEX10 WDFY4	1.35e-08	222	54	9	1.25.10.10
Domain	ARM-like	RSPH14 AP5Z1 LRRK2 TOGARAM2 ULK4 TTI1 IPO4 TEX10 WDFY4	7.27e-08	270	54	9	IPR011989
Domain	Leu-rich_rpt	FLII FBXL14 TLR4 TONSL LRRK2 LRRC28 TLR9 CEP97	1.03e-06	271	54	8	IPR001611
Domain	LRR_1	FLII FBXL14 TLR4 LRRK2 LRRC28 TLR9 CEP97	3.07e-06	219	54	7	PF00560
Domain	-	FLII FBXL14 TLR4 TONSL LRRK2 LRRC28 TLR9 CEP97	3.65e-06	321	54	8	3.80.10.10
Domain	L_dom-like	FLII FBXL14 TLR4 TONSL LRRK2 LRRC28 TLR9 CEP97	4.28e-06	328	54	8	IPR032675
Domain	ARM-type_fold	RSPH14 LRRK2 TOGARAM2 ULK4 TTI1 IPO4 TEX10 WDFY4	5.45e-06	339	54	8	IPR016024
Domain	DDI1_N	DDI2 DDI1	8.21e-06	2	54	2	IPR033882
Domain	LRR_6	FBXL14 TLR4 TONSL TLR9	1.91e-05	55	54	4	PF13516
Domain	Asp_protease	DDI2 DDI1	8.16e-05	5	54	2	PF09668
Domain	Peptidase_aspartic_DDI1-type	DDI2 DDI1	8.16e-05	5	54	2	IPR019103
Domain	LRR_8	FLII TLR4 LRRK2 LRRC28 TLR9	1.34e-04	171	54	5	PF13855
Domain	Leu-rich_rpt_typical-subtyp	FLII TLR4 LRRK2 LRRC28 TLR9	1.57e-04	177	54	5	IPR003591
Domain	LRR_TYP	FLII TLR4 LRRK2 LRRC28 TLR9	1.57e-04	177	54	5	SM00369
Domain	LRR	FLII TLR4 LRRK2 TLR9 CEP97	2.83e-04	201	54	5	PS51450
Domain	Leu-rich_rpt_4	FLII LRRK2	3.64e-04	10	54	2	IPR025875
Domain	LRR_4	FLII LRRK2	3.64e-04	10	54	2	PF12799
Domain	-	DDI2 DDI1	5.32e-04	12	54	2	2.40.70.10
Domain	VitD_rcpt	NR1D2 VDR	7.30e-04	14	54	2	IPR000324
Domain	HEAT_type_2	IPO4 TEX10	1.09e-03	17	54	2	IPR021133
Domain	Peptidase_aspartic_dom	DDI2 DDI1	1.09e-03	17	54	2	IPR021109
Domain	HEAT_REPEAT	ULK4 IPO4 TEX10	1.09e-03	70	54	3	PS50077
Domain	TIR	TLR4 TLR9	1.66e-03	21	54	2	SM00255
Domain	TIR	TLR4 TLR9	1.83e-03	22	54	2	PF01582
Domain	-	TLR4 TLR9	2.00e-03	23	54	2	3.40.50.10140
Domain	TIR	TLR4 TLR9	2.17e-03	24	54	2	PS50104
Domain	TIR_dom	TLR4 TLR9	2.36e-03	25	54	2	IPR000157
Domain	GDS_CDC24_CS	TRIO ARHGEF1	5.68e-03	39	54	2	IPR001331
Domain	zf-C4	NR1D2 VDR	7.83e-03	46	54	2	PF00105
Domain	Znf_hrmn_rcpt	NR1D2 VDR	7.83e-03	46	54	2	IPR001628
Domain	Nuclear_hrmn_rcpt	NR1D2 VDR	7.83e-03	46	54	2	IPR001723
Domain	NUCLEAR_REC_DBD_2	NR1D2 VDR	7.83e-03	46	54	2	PS51030
Domain	NUCLEAR_REC_DBD_1	NR1D2 VDR	7.83e-03	46	54	2	PS00031
Domain	ZnF_C4	NR1D2 VDR	7.83e-03	46	54	2	SM00399
Domain	-	NR1D2 VDR	8.16e-03	47	54	2	1.10.565.10
Domain	ubiquitin	DDI2 DDI1	8.16e-03	47	54	2	PF00240
Domain	HOLI	NR1D2 VDR	8.50e-03	48	54	2	SM00430
Domain	Nucl_hrmn_rcpt_lig-bd	NR1D2 VDR	8.50e-03	48	54	2	IPR000536
Domain	Hormone_recep	NR1D2 VDR	8.50e-03	48	54	2	PF00104
Domain	HEAT	IPO4 TEX10	8.50e-03	48	54	2	PF02985
Pubmed	Association of SLC11A1 with tuberculosis and interactions with NOS2A and TLR2 in African-Americans and Caucasians.	TLR4 TLR9 VDR	8.61e-07	12	56	3	19723394
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TANC2 MPP3 FLII RADIL MDN1 TRIO FBXL14 ZDHHC7 ULK4 DOCK6 DCTN1	1.27e-06	1105	56	11	35748872
Pubmed	The toll-like receptor pathway: a novel mechanism of infection-induced carcinogenesis of prostate epithelial cells.	TLR4 TLR9	2.55e-06	2	56	2	18092352
Pubmed	Coordinate binding studies of the substrate (factor X) with the cofactor (factor VIII) in the assembly of the factor X activating complex on the activated platelet surface.	F8 F10	2.55e-06	2	56	2	12220193
Pubmed	TLR-Stimulated Eosinophils Mediate Recruitment and Activation of NK Cells In Vivo.	TLR4 TLR9	2.55e-06	2	56	2	28426135
Pubmed	The influence of Flightless I on Toll-like-receptor-mediated inflammation in a murine model of diabetic wound healing.	FLII TLR4	2.55e-06	2	56	2	23555084
Pubmed	Acquisition of adult-like TLR4 and TLR9 responses during the first year of life.	TLR4 TLR9	2.55e-06	2	56	2	20442853
Pubmed	Activated factor X cleaves factor VIII at arginine 562, limiting its cofactor efficiency.	F8 F10	2.55e-06	2	56	2	19874476
Pubmed	Assessment of TLR4 and TLR9 signaling and correlation with human papillomavirus status and histopathologic parameters in oral tongue squamous cell carcinoma.	TLR4 TLR9	2.55e-06	2	56	2	32173390
Pubmed	Increased expression of Toll-like receptors 4 and 9 in human lung cancer.	TLR4 TLR9	2.55e-06	2	56	2	18763053
Pubmed	Alveolar bone loss in relation to toll-like receptor 4 and 9 genotypes and Porphyromonas gingivalis carriage.	TLR4 TLR9	2.55e-06	2	56	2	27492306
Pubmed	Flightless I Negatively Regulates Macrophage Surface TLR4, Delays Early Inflammation, and Impedes Wound Healing.	FLII TLR4	2.55e-06	2	56	2	35883634
Pubmed	Helicobacter pylori regulates TLR4 and TLR9 during gastric carcinogenesis.	TLR4 TLR9	2.55e-06	2	56	2	25400780
Pubmed	Toll-like receptor gene polymorphisms are associated with susceptibility to Graves' ophthalmopathy in Taiwan males.	TLR4 TLR9	2.55e-06	2	56	2	21050493
Pubmed	TLR4 896A/G and TLR9 1174G/A polymorphisms are associated with the risk of infectious mononucleosis.	TLR4 TLR9	2.55e-06	2	56	2	32753695
Pubmed	Polymorphisms and haplotypes of TLR-4/9 associated with bacterial infection, gingival inflammation/recession and oral cancer.	TLR4 TLR9	2.55e-06	2	56	2	36563560
Pubmed	TLR4 and TLR9 polymorphism: Probable role in susceptibility among the population of Bihar for Indian visceral leishmaniasis.	TLR4 TLR9	2.55e-06	2	56	2	33910419
Pubmed	Polymorphisms and expression of TLR4 and 9 in malaria in two ethnic groups of Assam, northeast India.	TLR4 TLR9	2.55e-06	2	56	2	22948021
Pubmed	Influence of TLR4 and TLR9 polymorphisms and haplotypes on multiple hrHPV infections and HPV16 copy number in cervical cancer and cervicitis.	TLR4 TLR9	2.55e-06	2	56	2	34416273
Pubmed	Toll-like receptor 4-induced ryanodine receptor 2 oxidation and sarcoplasmic reticulum Ca2+ leakage promote cardiac contractile dysfunction in sepsis.	TLR4 RYR2	2.55e-06	2	56	2	29150444
Pubmed	Sequences flanking Arg336 in factor VIIIa modulate factor Xa-catalyzed cleavage rates at this site and cofactor function.	F8 F10	2.55e-06	2	56	2	22411993
Pubmed	Altered interactions between the A1 and A2 subunits of factor VIIIa following cleavage of A1 subunit by factor Xa.	F8 F10	2.55e-06	2	56	2	12426309
Pubmed	Common polymorphisms of toll-like receptors 4 and 9 are associated with the clinical manifestation of malaria during pregnancy.	TLR4 TLR9	2.55e-06	2	56	2	16779724
Pubmed	TLR9 2848 GA heterozygotic status possibly predisposes fetuses and newborns to congenital infection with human cytomegalovirus.	TLR4 TLR9	2.55e-06	2	56	2	25844529
Pubmed	Signaling crosstalk during sequential TLR4 and TLR9 activation amplifies the inflammatory response of mouse macrophages.	TLR4 TLR9	2.55e-06	2	56	2	19923461
Pubmed	Differential involvement of IFN-beta in Toll-like receptor-stimulated dendritic cell activation.	TLR4 TLR9	2.55e-06	2	56	2	12356687
Pubmed	Immunohistochemical expression of TLR4 and TLR9 in various grades of oral epithelial dysplasia and squamous cell carcinoma, and their roles in tumor progression: a pilot study.	TLR4 TLR9	2.55e-06	2	56	2	23651260
Pubmed	Role of factor VIII C2 domain in factor VIII binding to factor Xa.	F8 F10	2.55e-06	2	56	2	10521497
Pubmed	Gene Polymorphisms of TLR4 and TLR9 and Haemophilus influenzae Meningitis in Angolan Children.	TLR4 TLR9	2.55e-06	2	56	2	32967147
Pubmed	Diverse Profiles of Toll-Like Receptors 2, 4, 7, and 9 mRNA in Peripheral Blood and Biopsy Specimens of Patients with Celiac Disease.	TLR4 TLR9	2.55e-06	2	56	2	30057921
Pubmed	The Impact of Circulating Mitochondrial DNA on Cardiomyocyte Apoptosis and Myocardial Injury After TLR4 Activation in Experimental Autoimmune Myocarditis.	TLR4 TLR9	2.55e-06	2	56	2	28618428
Pubmed	A membrane-interactive surface on the factor VIII C1 domain cooperates with the C2 domain for cofactor function.	F8 F10	2.55e-06	2	56	2	21156843
Pubmed	TLR4- and TLR9-dependent effects on cytokines, cell viability, and invasion in human bladder cancer cells.	TLR4 TLR9	2.55e-06	2	56	2	25499923
Pubmed	Interactions between residues 2228-2240 within factor VIIIa C2 domain and factor IXa Gla domain contribute to propagation of clot formation.	F8 F10	2.55e-06	2	56	2	21947241
Pubmed	Interactions of surface-expressed TLR-4 and endosomal TLR-9 accelerate lupus progression in anti-dsDNA antibody transgenic mice.	TLR4 TLR9	2.55e-06	2	56	2	24719374
Pubmed	Differential cell reaction upon Toll-like receptor 4 and 9 activation in human alveolar and lung interstitial macrophages.	TLR4 TLR9	2.55e-06	2	56	2	20843333
Pubmed	Associations of toll-like receptor 4 and 2 gene polymorphisms with susceptibility to ankylosing spondylitis: A meta-analysis.	TLR4 TLR9	2.55e-06	2	56	2	33369094
Pubmed	TLR9 and MyD88 are crucial for the development of protective immunity to malaria.	TLR4 TLR9	2.55e-06	2	56	2	22516959
Pubmed	Contribution of Factor VIII A2 Domain Residues 400-409 to a Factor X-Interactive Site in the Factor Xase Complex.	F8 F10	2.55e-06	2	56	2	29614522
Pubmed	Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation.	TLR4 TLR9	2.55e-06	2	56	2	12515817
Pubmed	Association of TLR4 and TLR9 gene polymorphisms and haplotypes with cervicitis susceptibility.	TLR4 TLR9	2.55e-06	2	56	2	31365550
Pubmed	Cigarette smoke increases TLR4 and TLR9 expression and induces cytokine production from CD8(+) T cells in chronic obstructive pulmonary disease.	TLR4 TLR9	2.55e-06	2	56	2	22070100
Pubmed	Study of disease-relevant polymorphisms in the TLR4 and TLR9 genes: a novel method applied to the analysis of the Portuguese population.	TLR4 TLR9	2.55e-06	2	56	2	17482427
Pubmed	Genetic variants of TLR4 and TLR9 are risk factors for chronic Helicobacter pylori infection in South Indian Tamils.	TLR4 TLR9	2.55e-06	2	56	2	27993530
Pubmed	Interaction of the A1 subunit of factor VIIIa and the serine protease domain of factor X identified by zero-length cross-linking.	F8 F10	2.55e-06	2	56	2	9759621
Pubmed	Association of polymorphisms in Toll-like receptors 4 and 9 with risk of pulmonary tuberculosis: a meta-analysis.	TLR4 TLR9	2.55e-06	2	56	2	25889916
Pubmed	Toll-like receptor 9 deficiency impacts sensory and motor behaviors.	TLR4 TLR9	2.55e-06	2	56	2	23624295
Pubmed	[Association of Toll-like receptor gene with Crohn's disease in Koreans].	TLR4 TLR9	2.55e-06	2	56	2	20026892
Pubmed	Association of TLR4 and TLR9 polymorphisms and haplotypes with cervical cancer susceptibility.	TLR4 TLR9	2.55e-06	2	56	2	31278284
Pubmed	Critical role of TLR9 in acute graft-versus-host disease.	TLR4 TLR9	2.55e-06	2	56	2	18941203
Pubmed	Toll-like receptor gene variants associated with bacterial vaginosis among HIV-1 infected adolescents.	TLR4 TLR9	2.55e-06	2	56	2	23021866
Pubmed	The agonists of TLR4 and 9 are sufficient to activate memory B cells to differentiate into plasma cells in vitro but not in vivo.	TLR4 TLR9	2.55e-06	2	56	2	18641311
Pubmed	Association of TLR4 and TLR9 gene polymorphisms with cervical HR-HPV infection status in Chinese Han population.	TLR4 TLR9	2.55e-06	2	56	2	36915050
Pubmed	Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy.	TLR4 LRRK2	2.55e-06	2	56	2	24682598
Pubmed	Polymorphisms in Toll-like receptors genes changes the host's immune response and is associated with cervical cancer.	TLR4 TLR9	2.55e-06	2	56	2	35158151
Pubmed	Importin 4 is responsible for ligand-independent nuclear translocation of vitamin D receptor.	IPO4 VDR	2.55e-06	2	56	2	16207705
Pubmed	TLR9 and TLR4 are required for the development of autoimmunity and lupus nephritis in pristane nephropathy.	TLR4 TLR9	2.55e-06	2	56	2	20810248
Pubmed	Factor VIII light chain contains a binding site for factor X that contributes to the catalytic efficiency of factor Xase.	F8 F10	2.55e-06	2	56	2	22224589
Pubmed	TLR4 deficiency upregulates TLR9 expression and enhances irinotecan-related intestinal mucositis and late-onset diarrhoea.	TLR4 TLR9	2.55e-06	2	56	2	34216140
Pubmed	Association between TLR4 and TLR9 gene polymorphisms with development of pulmonary tuberculosis in Zahedan, southeastern Iran.	TLR4 TLR9	2.55e-06	2	56	2	23766695
Pubmed	TLR4 and TLR9 are induced in oral lichen planus.	TLR4 TLR9	2.55e-06	2	56	2	22672741
Pubmed	Association of TLR4 and TLR9 gene polymorphisms with the risk and progression of cervical lesions in HPV-infected women.	TLR4 TLR9	2.55e-06	2	56	2	37097031
Pubmed	TLR4 and TLR9 polymorphisms are not associated with either rheumatoid arthritis or systemic lupus erythematosus in Mexican patients.	TLR4 TLR9	2.55e-06	2	56	2	33939072
Pubmed	TLR2, TLR4 and TLR9 polymorphisms and Crohn's disease in a New Zealand Caucasian cohort.	TLR4 TLR9	7.63e-06	3	56	2	17914947
Pubmed	Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils.	TLR4 TLR9	7.63e-06	3	56	2	27505671
Pubmed	Quantitative proteomics reveals neuronal ubiquitination of Rngo/Ddi1 and several proteasomal subunits by Ube3a, accounting for the complexity of Angelman syndrome.	DDI2 DDI1	7.63e-06	3	56	2	29788202
Pubmed	Expression of toll-like receptors on antigen-presenting cells in patients with falciparum malaria.	TLR4 TLR9	7.63e-06	3	56	2	17854755
Pubmed	Enhanced efficacy of therapeutic cancer vaccines produced by co-treatment with Mycobacterium tuberculosis heparin-binding hemagglutinin, a novel TLR4 agonist.	TLR4 TLR9	7.63e-06	3	56	2	21368092
Pubmed	[Toll-like receptor gene polymorphisms and susceptibility to inflammatory bowel disease in Chinese Han and Caucasian populations].	TLR4 TLR9	7.63e-06	3	56	2	20646633
Pubmed	Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria.	TLR4 TLR9	7.63e-06	3	56	2	16371473
Pubmed	Toll-like receptor signaling in anti-cancer immunity.	TLR4 TLR9	7.63e-06	3	56	2	12630564
Pubmed	Single-nucleotide polymorphisms in the Toll-like receptor pathway increase susceptibility to infections in severely injured trauma patients.	TLR4 TLR9	7.63e-06	3	56	2	23425749
Pubmed	Systemically administered ligands of Toll-like receptor 2, -4, and -9 induce distinct inflammatory responses in the murine lung.	TLR4 TLR9	7.63e-06	3	56	2	21547259
Pubmed	A pilot study on expression of toll like receptors (TLRs) in response to herpes simplex virus (HSV) infection in acute retinal pigment epithelial cells (ARPE) cells.	TLR4 TLR9	7.63e-06	3	56	2	25121361
Pubmed	Toll-like receptor stimulation enhances phagocytosis and intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia.	TLR4 TLR9	7.63e-06	3	56	2	19933834
Pubmed	Activation of enteroendocrine cells via TLRs induces hormone, chemokine, and defensin secretion.	TLR4 TLR9	7.63e-06	3	56	2	17371986
Pubmed	Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia.	TLR4 TLR9	7.63e-06	3	56	2	20804821
Pubmed	Kinetics of coagulation factor X activation by platelet-bound factor IXa.	F8 F10	7.63e-06	3	56	2	2110473
Pubmed	Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis.	TLR4 TLR9	7.63e-06	3	56	2	18275280
Pubmed	TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells.	TLR4 TLR9	7.63e-06	3	56	2	20526283
Pubmed	Polymorphisms in Toll-like receptor genes and susceptibility to infections in allogeneic stem cell transplantation.	TLR4 TLR9	7.63e-06	3	56	2	19539691
Pubmed	Toll-like receptor 2 regulates CXC chemokine production and neutrophil recruitment to the cornea in Onchocerca volvulus/Wolbachia-induced keratitis.	TLR4 TLR9	7.63e-06	3	56	2	17875630
Pubmed	Polymorphisms in Toll-like receptors 2, 4, and 9 are highly associated with hearing loss in survivors of bacterial meningitis.	TLR4 TLR9	7.63e-06	3	56	2	22662111
Pubmed	Impaired Surface Expression of HLA-DR, TLR2, TLR4, and TLR9 in Ex Vivo-In Vitro Stimulated Monocytes from Severely Injured Trauma Patients.	TLR4 TLR9	7.63e-06	3	56	2	28255201
Pubmed	Cathelicidin modulates synthesis of Toll-like Receptors (TLRs) 4 and 9 in colonic epithelium.	TLR4 TLR9	7.63e-06	3	56	2	28988039
Pubmed	Association between genetic variants of TLR2, TLR4, TLR9 and schizophrenia.	TLR4 TLR9	7.63e-06	3	56	2	37718198
Pubmed	Evaluation of the detection of Toll-like receptors (TLRs) in cancer development and progression in patients with colorectal cancer.	TLR4 TLR9	7.63e-06	3	56	2	29883450
Pubmed	Stimulation of allergen-loaded macrophages by TLR9-ligand potentiates IL-10-mediated suppression of allergic airway inflammation in mice.	TLR4 TLR9	7.63e-06	3	56	2	15538945
Pubmed	TLR9 cooperates with TLR4 to increase IL-12 release by murine dendritic cells.	TLR4 TLR9	7.63e-06	3	56	2	17599410
Pubmed	Genetic variation of TLR-4, TLR-9 and TIRAP genes in Iranian malaria patients.	TLR4 TLR9	7.63e-06	3	56	2	21457584
Pubmed	TLR9-IL-2 axis exacerbates allergic asthma by preventing IL-17A hyperproduction.	TLR4 TLR9	7.63e-06	3	56	2	33093516
Pubmed	Association of toll-like receptor gene polymorphisms and its interaction with HPV infection in determining the susceptibility of cervical cancer in Chinese Han population.	TLR4 TLR9	7.63e-06	3	56	2	28497211
Pubmed	Live Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis activate the inflammatory response through Toll-like receptors 2, 4, and 9 in species-specific patterns.	TLR4 TLR9	7.63e-06	3	56	2	16731773
Pubmed	Expressions of Toll-like receptors 3, 4, 7, and 9 in cervical lesions and their correlation with HPV16 infection in Uighur women.	TLR4 TLR9	7.63e-06	3	56	2	21527067
Pubmed	Quantitative defects in invariant NKT cells and TLR responses in patients with hyper-IgE syndrome.	TLR4 TLR9	7.63e-06	3	56	2	25796310
Pubmed	Macrophage Toll-like Receptor 9 Contributes to Chemotherapy-Induced Neuropathic Pain in Male Mice.	TLR4 TLR9	7.63e-06	3	56	2	31270160
Pubmed	Genetic alterations within TLR genes in development of Toxoplasma gondii infection among Polish pregnant women.	TLR4 TLR9	7.63e-06	3	56	2	28500897
Pubmed	Increased Expression of Toll-Like Receptors 4, 5, and 9 in Small Bowel Mucosa from Patients with Irritable Bowel Syndrome.	TLR4 TLR9	7.63e-06	3	56	2	28246611
Pubmed	Extracts of Larix Leptolepis effectively augments the generation of tumor antigen-specific cytotoxic T lymphocytes via activation of dendritic cells in TLR-2 and TLR-4-dependent manner.	TLR4 TLR9	7.63e-06	3	56	2	22677561
Pubmed	Influence of genetic variability in toll-like receptors (TLR 2, TLR 4, and TLR 9) on human immunodeficiency virus-1 disease progression.	TLR4 TLR9	7.63e-06	3	56	2	36926756
GeneFamily	CD molecules\|Toll like receptors	TLR4 TLR9	1.53e-04	10	34	2	948
GeneFamily	Nuclear hormone receptors	NR1D2 VDR	3.82e-03	49	34	2	71
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	TRIO ARHGEF1	6.83e-03	66	34	2	722
Disease	hyperhomocysteinemia (implicated_via_orthology)	GRIN2A F8 F10	8.94e-07	11	53	3	DOID:9279 (implicated_via_orthology)
Disease	pulmonary tuberculosis (is_implicated_in)	TLR4 TLR9 TAP2 VDR	9.87e-07	42	53	4	DOID:2957 (is_implicated_in)
Disease	mastitis (biomarker_via_orthology)	TLR4 TLR9	3.17e-06	2	53	2	DOID:10690 (biomarker_via_orthology)
Disease	allergic contact dermatitis (is_implicated_in)	TLR4 TAP2	4.73e-05	6	53	2	DOID:3042 (is_implicated_in)
Disease	Crohn Disease	TLR4 LRRK2 TLR9	1.01e-04	50	53	3	C0010346
Disease	cutaneous leishmaniasis (is_marker_for)	TLR4 TLR9	1.41e-04	10	53	2	DOID:9111 (is_marker_for)
Disease	allergic conjunctivitis (is_marker_for)	TLR4 TLR9	1.41e-04	10	53	2	DOID:11204 (is_marker_for)
Disease	wellbeing measurement	ASXL3 TLR4 LRRK2 GRIN2A LRRC28 RMC1 TAP2	2.29e-04	692	53	7	EFO_0007869
Disease	allergic rhinitis (is_marker_for)	TLR4 TLR9	4.23e-04	17	53	2	DOID:4481 (is_marker_for)
Disease	dermatomyositis (is_marker_for)	TLR4 TLR9	4.23e-04	17	53	2	DOID:10223 (is_marker_for)
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR4 TLR9	4.23e-04	17	53	2	DOID:8677 (biomarker_via_orthology)
Disease	sinusitis (is_marker_for)	TLR4 TLR9	4.75e-04	18	53	2	DOID:0050127 (is_marker_for)
Disease	Neurodevelopmental Disorders	TANC2 TRIO ASXL3	6.33e-04	93	53	3	C1535926
Disease	vitiligo (is_implicated_in)	TLR4 VDR	6.50e-04	21	53	2	DOID:12306 (is_implicated_in)
Disease	acute necrotizing pancreatitis (biomarker_via_orthology)	TLR4 TLR9	1.00e-03	26	53	2	DOID:0080998 (biomarker_via_orthology)
Disease	atopic dermatitis (is_implicated_in)	TLR4 VDR	1.00e-03	26	53	2	DOID:3310 (is_implicated_in)
Disease	anogenital venereal wart (is_marker_for)	TLR4 TLR9	1.00e-03	26	53	2	DOID:11168 (is_marker_for)
Disease	Epilepsy	TANC2 ASXL3 GRIN2A	1.00e-03	109	53	3	C0014544
Disease	non-alcoholic fatty liver disease (is_marker_for)	TLR9 VDR	1.08e-03	27	53	2	DOID:0080208 (is_marker_for)
Disease	Autosomal Dominant Parkinsonism	LRRK2 DCTN1	1.16e-03	28	53	2	C0752098
Disease	Autosomal Dominant Juvenile Parkinson Disease	LRRK2 DCTN1	1.16e-03	28	53	2	C0752097
Disease	Parkinsonism, Experimental	LRRK2 DCTN1	1.16e-03	28	53	2	C0752101
Disease	Autosomal Recessive Parkinsonism	LRRK2 DCTN1	1.16e-03	28	53	2	C0752100
Disease	Familial Juvenile Parkinsonism	LRRK2 DCTN1	1.16e-03	28	53	2	C0752104
Disease	Ramsay Hunt Paralysis Syndrome	LRRK2 DCTN1	1.16e-03	28	53	2	C0242423
Disease	PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE	LRRK2 DCTN1	1.16e-03	28	53	2	C1868675
Disease	Parkinsonism, Juvenile	LRRK2 DCTN1	1.33e-03	30	53	2	C0752105
Disease	Parkinsonian Disorders	LRRK2 DCTN1	1.33e-03	30	53	2	C0242422
Disease	venous thromboembolism	TLR4 TOGARAM2 GRIN2A F8 F10	1.40e-03	460	53	5	EFO_0004286
Disease	psoriasis (is_implicated_in)	TAP2 VDR	1.71e-03	34	53	2	DOID:8893 (is_implicated_in)
Disease	melanoma (is_implicated_in)	TLR4 VDR	1.71e-03	34	53	2	DOID:1909 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
RLLHSLVTSALQPMA	UMODL1	196	Q5DID0
LSQLSMLPHLADLVS	VDR	221	P11473
LMLRNTATADLAHPL	ESX1	201	Q8N693
RLDLSHLRQSSDPML	ARHGEF1	621	Q92888
SLPICMLELLLHISS	ADM5	121	C9JUS6
PLLLQQISAMRLHIS	DCTN1	1091	Q14203
LPQLLLRMISALTSH	DOP1A	506	Q5JWR5
LLLSKMRTLAHSPAT	AP5Z1	721	O43299
QFLHSLRLAMSDLTP	HSD11B2	306	P80365
LLSPRQVHLLLDMLA	ATG2B	321	Q96BY7
SLSSAPHQLRLANML	ASXL3	1976	Q9C0F0
PHLEDTLLQRIMTLI	RADIL	411	Q96JH8
IRSMLLSNPHDLSLL	DDI1	146	Q8WTU0
MLHLHPLDLQSALSI	MDN1	4156	Q9NU22
LLHAQLRQLPAMTAL	FLII	186	Q13045
LRQLPAMTALQTLHL	FLII	191	Q13045
MALTPLLLLLLSHCT	IGLV11-55	1	A0A075B6I3
AILNLPHLRSLDMSS	LRRK2	1191	Q5S007
DLMPHDLITQLLRVL	TUBGCP2	576	Q9BSJ2
LTLSDLPLHMLNNIL	FBXO25	226	Q8TCJ0
SSDLLMLLRQSPTPH	F8	806	P00451
LLHLSHMGSLRSLNL	FBXL14	246	Q8N1E6
MSHLQSLLLDTLLGT	PFN4	1	Q8NHR9
SMALHLLLGQRLDTP	DOCK6	941	Q96HP0
LDSLSPSVHMRSLLL	CPLANE1	426	Q9H799
LLLHGNIITSLRMAP	CEP97	151	Q8IW35
ALLRDMLLANPHELS	DDI2	136	Q5TDH0
MGRPLHLVLLSASLA	F10	1	P00742
MTTQLRVVHLLPLLL	GPX5	1	O75715
LLTNLSEHMPNDTRL	RYR2	4101	Q92736
LAPHLEQITTLMLLS	IPO4	601	Q8TEX9
SLMLALSRHSLLSPL	SDHAF2	11	Q9NX18
LLQLLSTPHLRAVLM	MPP3	91	Q13368
LKLPDLRSLNNMHSE	NR1D2	556	Q14995
LLRESLHPMLLSIII	TOGARAM2	836	Q6ZUX3
LLTLPERLHMCLSLQ	LRRC28	146	Q86X40
LMSALAARLLQPAHS	MTHFD2	6	P13995
QLLREPHLQSMLSLR	TANC2	491	Q9HCD6
LSISPRLTLLSLLHM	TAP2	286	Q03519
RLTLLSLLHMPFTIA	TAP2	291	Q03519
PLSLIDDLHSQMLSS	MRTFA	836	Q969V6
AMILLSSLTVHPILR	CMTM2	101	Q8TAZ6
ALMRLSKPLTLSAHI	TMPRSS13	416	Q9BYE2
DMTHLTELALRLPLQ	VPS35L	946	Q7Z3J2
PAHQLSLDMLKRLST	RMC1	546	Q96DM3
SALHPLSLLVQAIML	TLR9	6	Q9NR96
LLLELLHSPMTIARL	RSPH14	276	Q9UHP6
TMPSLALLDLSSNHL	TONSL	1096	Q96HA7
LEMLLSVISSPQLHL	WDFY4	1596	Q6ZS81
LLLQHAPLRTHMLTN	TEX10	866	Q9NXF1
VLALSSHLRTMLTDP	ZDHHC7	91	Q9NXF8
LSRMLSTHNLPCLLV	ZMYND10	206	O75800
RVLHQMPLLNLSLDL	TLR4	196	O00206
LRSLLLNPHLRQLMV	ZNHIT3	101	Q15649
NLLPKVSTMLDRLHS	TRIO	306	O75962
PLLFSLLDILHSMLT	ULK4	1106	Q96C45
ESLHSLATSLPRLMN	TTI1	376	O43156
ALLMNRTDPKSLITH	GRIN2A	71	Q12879