Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	ALOXE3 ALOX15B	5.18e-04	25	27	2	GO:0016702
GeneOntologyMolecularFunction	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	ALOXE3 ALOX15B	5.61e-04	26	27	2	GO:0016701
GeneOntologyBiologicalProcess	hepoxilin metabolic process	ALOXE3 ALOX15B	4.26e-05	8	26	2	GO:0051121
GeneOntologyBiologicalProcess	hepoxilin biosynthetic process	ALOXE3 ALOX15B	4.26e-05	8	26	2	GO:0051122
GeneOntologyBiologicalProcess	lipoxygenase pathway	ALOXE3 ALOX15B	8.35e-05	11	26	2	GO:0019372
GeneOntologyBiologicalProcess	monocarboxylic acid biosynthetic process	ALOXE3 LIPC OSBPL3 ALOX15B	2.96e-04	260	26	4	GO:0072330
GeneOntologyBiologicalProcess	sensory perception of pain	MRGPRX2 ALOXE3 CHRNA5	3.06e-04	105	26	3	GO:0019233
GeneOntologyBiologicalProcess	linoleic acid metabolic process	ALOXE3 ALOX15B	3.80e-04	23	26	2	GO:0043651
Domain	LH2	ALOXE3 LIPC ALOX15B PKD1L1	1.22e-08	18	28	4	SM00308
Domain	PLAT	ALOXE3 LIPC ALOX15B PKD1L1	2.38e-08	21	28	4	PF01477
Domain	PLAT	ALOXE3 LIPC ALOX15B PKD1L1	2.38e-08	21	28	4	PS50095
Domain	PLAT/LH2_dom	ALOXE3 LIPC ALOX15B PKD1L1	2.38e-08	21	28	4	IPR001024
Domain	-	ALOXE3 LIPC ALOX15B PKD1L1	2.38e-08	21	28	4	2.60.60.20
Domain	LIPOXYGENASE_2	ALOXE3 ALOX15B	3.24e-05	6	28	2	PS00081
Domain	LipOase	ALOXE3 ALOX15B	3.24e-05	6	28	2	IPR000907
Domain	LipOase_Fe_BS	ALOXE3 ALOX15B	3.24e-05	6	28	2	IPR020833
Domain	LipOase_CS	ALOXE3 ALOX15B	3.24e-05	6	28	2	IPR020834
Domain	LipOase_mml	ALOXE3 ALOX15B	3.24e-05	6	28	2	IPR001885
Domain	LIPOXYGENASE_1	ALOXE3 ALOX15B	3.24e-05	6	28	2	PS00711
Domain	LipOase_C	ALOXE3 ALOX15B	3.24e-05	6	28	2	IPR013819
Domain	Lipoxygenase	ALOXE3 ALOX15B	3.24e-05	6	28	2	PF00305
Domain	LIPOXYGENASE_3	ALOXE3 ALOX15B	3.24e-05	6	28	2	PS51393
Domain	PH_dom-like	LYST OSBPL3 TECPR1 ARHGEF9	3.54e-03	426	28	4	IPR011993
Domain	PH	OSBPL3 TECPR1 ARHGEF9	8.12e-03	278	28	3	SM00233
Domain	PH_DOMAIN	OSBPL3 TECPR1 ARHGEF9	8.20e-03	279	28	3	PS50003
Domain	PH_domain	OSBPL3 TECPR1 ARHGEF9	8.28e-03	280	28	3	IPR001849
Pubmed	Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13.	ALOXE3 ALOX15B	1.87e-06	3	28	2	17139268
Pubmed	A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression.	ALOXE3 ALOX15B	3.75e-06	4	28	2	11350124
Pubmed	Expression of inactive glutathione peroxidase 4 leads to embryonic lethality, and inactivation of the Alox15 gene does not rescue such knock-in mice.	ALOXE3 ALOX15B	9.36e-06	6	28	2	25313597
Pubmed	Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation.	AK9 RBX1	6.33e-04	46	28	2	31560077
Cytoband	6q21	AK9 SEC63	1.58e-03	96	28	2	6q21
Cytoband	17p13.1	ALOXE3 ALOX15B	2.37e-03	118	28	2	17p13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr6q21	AK9 SEC63	2.49e-03	121	28	2	chr6q21
Cytoband	Ensembl 112 genes in cytogenetic band chr7q21	STEAP1 TECPR1	5.29e-03	178	28	2	chr7q21
Cytoband	Ensembl 112 genes in cytogenetic band chr22q12	SFI1 MYO18B	9.03e-03	235	28	2	chr22q12
Cytoband	Ensembl 112 genes in cytogenetic band chr17p13	ALOXE3 ALOX15B	1.88e-02	346	28	2	chr17p13
GeneFamily	Arachidonate lipoxygenases	ALOXE3 ALOX15B	1.57e-05	6	19	2	407
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	OSBPL3 ARHGEF9	1.94e-02	206	19	2	682
Drug	AC1L9K72	ALOXE3 LIPC LYST ALOX15B ARHGEF9	2.50e-05	290	28	5	CID000446872
Drug	12-IODE	ALOXE3 ALOX15B	3.05e-05	7	28	2	CID006450050
Drug	colneleic acid	ALOXE3 ALOX15B	4.07e-05	8	28	2	CID006441681
Drug	htyA	ALOXE3 ALOX15B	4.07e-05	8	28	2	CID000152267
Drug	14,15-leukotriene A4	ALOXE3 ALOX15B	5.22e-05	9	28	2	CID006439604
Drug	octadeca-9,12-dien-1-ol	ALOXE3 ALOX15B	5.22e-05	9	28	2	CID000068168
Drug	8,15-diHPETE	ALOXE3 ALOX15B	5.22e-05	9	28	2	CID005283181
Drug	13-hydroxylinoleic acid	ALOXE3 ALOX15B	5.22e-05	9	28	2	CID006438633
Drug	AC1NSXHC	ALOXE3 ALOX15B	5.22e-05	9	28	2	CID005371969
Drug	U-66,855	ALOXE3 ALOX15B	5.22e-05	9	28	2	CID000127235
Drug	ODYA	ALOXE3 ALOX15B	5.22e-05	9	28	2	CID000001931
Drug	9-HPODE	ALOXE3 ALOX15B	6.52e-05	10	28	2	CID000001928
Drug	1,4-pentadiene	ALOXE3 ALOX15B	6.52e-05	10	28	2	CID000011587
Drug	Desipramine hydrochloride [58-28-6]; Up 200; 13.2uM; MCF7; HT_HG-U133A	SFI1 THSD1 IDI1 LYST	6.96e-05	182	28	4	5292_UP
Drug	acetone phenylhydrazone	ALOXE3 ALOX15B	7.97e-05	11	28	2	CID000066026
Drug	Ity A	ALOXE3 ALOX15B	7.97e-05	11	28	2	CID000188274
Drug	Ethoxyquin [91-53-2]; Up 200; 18.4uM; MCF7; HT_HG-U133A	PHTF2 ALOXE3 SFI1 LYST	8.91e-05	194	28	4	3846_UP
Drug	Hesperidin [520-26-3]; Up 200; 6.6uM; MCF7; HT_HG-U133A	OAS2 SFI1 THSD1 LYST	9.09e-05	195	28	4	5313_UP
Drug	Piroxicam [36322-90-4]; Up 200; 12uM; MCF7; HT_HG-U133A	PHTF2 SFI1 THSD1 ARHGEF9	9.46e-05	197	28	4	2252_UP
Drug	Acebutolol hydrochloride [34381-68-5]; Up 200; 10.8uM; MCF7; HT_HG-U133A	PHTF2 ALOXE3 SFI1 ARHGEF9	9.46e-05	197	28	4	4976_UP
Drug	Dubinidine [22964-77-8]; Up 200; 14.6uM; MCF7; HT_HG-U133A	OAS2 ALOXE3 SFI1 POLG	9.46e-05	197	28	4	6250_UP
Drug	Arcaine sulfate [14923-17-2]; Down 200; 14.8uM; MCF7; HT_HG-U133A	OAS2 SFI1 LYST POLG	9.46e-05	197	28	4	4974_DN
Drug	nonenal	ALOXE3 ALOX15B	9.55e-05	12	28	2	CID003015503
Drug	0173570-0000 [211245-44-2]; Up 200; 1uM; PC3; HT_HG-U133A	OAS2 POLG ALOX15B ARHGEF9	9.65e-05	198	28	4	7391_UP
Drug	LY 294002; Up 200; 0.1uM; HL60; HT_HG-U133A	PHTF2 THSD1 LYST POLG	9.65e-05	198	28	4	1157_UP
Drug	Cloxacillin sodium salt [642-78-4]; Down 200; 8.8uM; MCF7; HT_HG-U133A	PHTF2 OAS2 SFI1 ARHGEF9	9.84e-05	199	28	4	2289_DN
Drug	GBR 12909 dihydrochloride [67469-78-7]; Down 200; 7.6uM; MCF7; HT_HG-U133A	OAS2 SFI1 LYST ARHGEF9	1.00e-04	200	28	4	3240_DN
Drug	AC1NR1Q2	ALOXE3 ALOX15B	1.13e-04	13	28	2	CID005283190
Drug	AC1L1BGZ	ALOXE3 ALOX15B	1.13e-04	13	28	2	CID000001435
Drug	9-HETE	ALOXE3 ALOX15B	1.13e-04	13	28	2	CID000001926
Drug	ICI207968	ALOXE3 ALOX15B	1.13e-04	13	28	2	CID000129095
Drug	AC1O4E1A	ALOXE3 ALOX15B	1.13e-04	13	28	2	CID006365736
Drug	AC1NR1LB	ALOXE3 ALOX15B	1.32e-04	14	28	2	CID005283131
Drug	oxphaman	ALOXE3 ALOX15B	1.32e-04	14	28	2	CID005464022
Drug	CL 246,738	OAS2 LYST	1.32e-04	14	28	2	CID000133711
Drug	timegadine	ALOXE3 ALOX15B	1.32e-04	14	28	2	CID000068902
Drug	5-HEPE	ALOXE3 ALOX15B	1.32e-04	14	28	2	CID000001766
Drug	17-HdoHE	ALOXE3 ALOX15B	1.32e-04	14	28	2	CID006439179
Drug	8R-HpETE	ALOXE3 ALOX15B	1.52e-04	15	28	2	CID005283170
Drug	Hex-3-enyl acetate	ALOXE3 ALOX15B	1.52e-04	15	28	2	CID000015574
Drug	8(S),15(S)-diHETE	ALOXE3 ALOX15B	1.52e-04	15	28	2	CID000001897
Drug	13-HpOTrE	ALOXE3 ALOX15B	1.52e-04	15	28	2	CID005282866
Drug	AC1NR1M2	ALOXE3 ALOX15B	1.73e-04	16	28	2	CID005283140
Drug	12R-HETrE	ALOXE3 ALOX15B	1.73e-04	16	28	2	CID005283149
Drug	peroxylinolenic acid	ALOXE3 ALOX15B	1.73e-04	16	28	2	CID006439905
Drug	hex-3-enal	ALOXE3 ALOX15B	1.73e-04	16	28	2	CID000023234
Drug	5,15-diHETE	ALOXE3 ALOX15B	1.96e-04	17	28	2	CID005283158
Drug	cirsiliol	ALOXE3 ALOX15B	1.96e-04	17	28	2	CID000160237
Drug	FPL 57231	ALOXE3 ALOX15B	2.20e-04	18	28	2	CID000122212
Drug	3-nonenal	ALOXE3 ALOX15B	2.20e-04	18	28	2	CID005283336
Drug	BW540C	ALOXE3 ALOX15B	2.20e-04	18	28	2	CID000134372
Drug	AC1O5PL5	ALOXE3 ALOX15B	2.20e-04	18	28	2	CID006438380
Drug	L-651,392	ALOXE3 ALOX15B	2.73e-04	20	28	2	CID000122182
Drug	TMK777	ALOXE3 ALOX15B	2.73e-04	20	28	2	CID006438911
Drug	AC1L2P35	ALOXE3 ALOX15B	2.73e-04	20	28	2	CID000125736
Drug	AC1O5S1P	ALOXE3 ALOX15B	3.02e-04	21	28	2	CID006439617
Drug	AC1NRAUB	ALOXE3 ALOX15B	3.02e-04	21	28	2	CID005288098
Drug	20-carboxyleukotriene B4	ALOXE3 ALOX15B	3.02e-04	21	28	2	CID000001588
Drug	BM 13.177	ALOXE3 ALOX15B	3.32e-04	22	28	2	CID000051550
Drug	5,8,11-eicosatrienoic acid	ALOXE3 ALOX15B	3.32e-04	22	28	2	CID000004028
Drug	CGS 8515	ALOXE3 ALOX15B	3.32e-04	22	28	2	CID000163944
Drug	diethylcarbamazine	ALOXE3 ALOX15B	3.32e-04	22	28	2	CID000003052
Drug	L-656,224	ALOXE3 ALOX15B	3.63e-04	23	28	2	CID000128132
Drug	AC1NSYHD	ALOXE3 ALOX15B	3.63e-04	23	28	2	CID005319705
Drug	octadecadienoic acid	ALOXE3 ALOX15B	3.63e-04	23	28	2	CID005312457
Drug	AC1L1X0Y	ALOXE3 LYST ALOX15B	3.94e-04	117	28	3	CID000062388
Drug	13-hydroperoxylinoleic acid	ALOXE3 ALOX15B	4.30e-04	25	28	2	CID006438144
Drug	pinolenic acid	ALOXE3 ALOX15B	4.30e-04	25	28	2	CID005312493
Drug	AC1L3X17	ALOXE3 ALOX15B	4.30e-04	25	28	2	CID000123644
Drug	AC1L3WDO	ALOXE3 ALOX15B	4.65e-04	26	28	2	CID000123344
Drug	11-HETE	ALOXE3 ALOX15B	4.65e-04	26	28	2	CID000001406
Drug	20-hydroxyleukotriene B4	ALOXE3 ALOX15B	4.65e-04	26	28	2	CID000001589
Drug	8-HETE	ALOXE3 ALOX15B	4.65e-04	26	28	2	CID000001898
Drug	Bhpp	ALOXE3 ALOX15B	5.02e-04	27	28	2	CID000164136
Drug	BW A4C	ALOXE3 ALOX15B	5.02e-04	27	28	2	CID006438354
Drug	SC-41930	ALOXE3 ALOX15B	5.02e-04	27	28	2	CID000114999
Drug	AC1L1G9E	ALOXE3 ALOX15B	5.40e-04	28	28	2	CID000003586
Drug	L-649,923	ALOXE3 ALOX15B	5.40e-04	28	28	2	CID000119331
Drug	13-epi-12-oxo-phytodienoic acid	ALOXE3 ALOX15B	5.80e-04	29	28	2	CID000188366
Drug	nafazatrom	ALOXE3 ALOX15B	5.80e-04	29	28	2	CID000042923
Disease	Parkinsonian Disorders	LYST POLG	3.20e-04	30	26	2	C0242422
Disease	dentate gyrus volume measurement	ALOX15B PKD1L1	5.42e-04	39	26	2	EFO_0010083

Protein segments in the cluster

Peptide	Gene	Start	Entry
WNGLWKSKWIFQVNP	CAPZA3	166	Q96KX2
KVLDASNKDWWWGQI	ARHGEF9	36	O43307
RFEVKKWNAVALWAW	RBX1	21	P62877
WDWLLAKTWVRNSEF	ALOXE3	386	Q9BYJ1
SQWKKWEVVAERAWK	POLG	1036	P54098
IKFKWENSAVWANVW	LIPC	416	P11150
ICWQWLKKEAQTWLT	OAS2	306	P29728
NVWLKQEWIDVKLRW	CHRNA5	96	P30532
WFKIIAATFLFKWWD	IDI1	196	Q13907
WKIWSKAEQGVWETL	LYST	1921	Q99698
FQWIRCLFWDKREWK	PKD1L1	1686	Q8TDX9
VFWQDVRWKNKFWGK	OSBPL3	646	Q9H4L5
WDWLLAKTWVRNAEF	ALOX15B	351	O15296
FHSKWWVWNEVIKNV	AK9	1586	Q5TCS8
LRKVFEEWKEEWWVF	SFI1	121	A8K8P3
FRWWLQVTSKVIFFW	PHTF2	126	Q8N3S3
LWTWWINFLFAAVVA	SLCO6A1	311	Q86UG4
VKWPNTNDICWAKVW	SI	1321	P14410
IQWFLILWIWKDSDV	MRGPRX2	241	Q96LB1
IFAWNKWIDIKQFVW	STEAP1	271	Q9UHE8
EKGLWWFQLKVWSMA	CLEC4C	11	Q8WTT0
SQYKDWWWKVQIGKC	TTC8	246	Q8TAM2
SVVWAVTKDWKVWFR	TECPR1	301	Q7Z6L1
WWEKSAFLKVEWPVF	THSD1	116	Q9NS62
EKQEWWWLYIADRKE	SEC63	646	Q9UGP8
ADWIWTFWGSNKQIK	REP15	91	Q6BDI9
KNVAVFLAVKDWPWW	MYO18B	1371	Q8IUG5
SWQDWKKAWDEWKQV	WDR87	1456	Q6ZQQ6