Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentearly endosome

TLR9 USP8 SORL1

9.17e-0448193GO:0005769
GeneOntologyCellularComponentGolgi cisterna

GAL3ST3 SORL1

1.45e-0313592GO:0031985
GeneOntologyCellularComponentendosome membrane

TLR9 USP8 SORL1

1.75e-0360293GO:0010008
GeneOntologyCellularComponentGolgi stack

GAL3ST3 SORL1

2.31e-0317192GO:0005795
GeneOntologyCellularComponentearly endosome membrane

TLR9 SORL1

3.52e-0321292GO:0031901
Pubmed

Sexual Fate Change of XX Germ Cells Caused by the Deletion of SMAD4 and STRA8 Independent of Somatic Sex Reprogramming.

TLR9 SMAD9

8.08e-06179227606421
Pubmed

Bone morphogenetic protein signaling in the developing telencephalon controls formation of the hippocampal dentate gyrus and modifies fear-related behavior.

SORL1 SMAD9

1.50e-05239220445055
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

PDE9A USP8 SORL1 SMAD9

2.24e-0413219427173435
InteractionHEYL interactions

HIPK3 SMAD9

8.19e-053192int:HEYL
InteractionHIPK1 interactions

PDE9A HIPK3

1.30e-043992int:HIPK1
InteractionICAM4 interactions

NGLY1 SORL1

1.82e-044692int:ICAM4
InteractionPSG1 interactions

NGLY1 SORL1

2.23e-045192int:PSG1
CytobandEnsembl 112 genes in cytogenetic band chr15q21

ZNF280D USP8

5.23e-0417792chr15q21
CoexpressionAtlasFacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#3

PDE9A ZNF280D NGLY1 SMAD9

1.46e-0483484Facebase_RNAseq_e10.5_Mandibular Arch_2500_K3
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000_k-means-cluster#2

PDE9A ZNF280D GAL3ST3

1.65e-0431183Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000_K2
ToppCellMS-CD4-CD8_2|MS / Condition, Cell_class and T cell subcluster

ZNF280D SORL1

3.86e-041499208fb6be5599c5988890c851ce5ac6781c319948e
ToppCellHealthy_Control-Lymphoid-Plasma|Healthy_Control / Condition, Lineage, Cell class and cell subclass

TLR9 SMAD9

4.62e-04163922913ccdd4613472cd82077d4993e1d9f8b223398
ToppCellHealthy_Control-Lymphoid-Plasma-|Healthy_Control / Condition, Lineage, Cell class and cell subclass

TLR9 SMAD9

4.62e-0416392b589ff57d58dcb215ee3b5a10d81f43e5752a196
ToppCell10x5'v1-week_12-13-Myeloid_DC-DC-pDC|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

NGLY1 TLR9

4.79e-04166929fa90d9d484563d44738bb2c6eb0775dffc4d549
ToppCellP15-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SORL1 SMAD9

5.02e-0417092ba4ba66b624089ed50a9083176386c7941b4c7a3
ToppCellnormal_Pleural_Fluid-Myeloid_cells-CD163+CD14+_DCs|normal_Pleural_Fluid / Location, Cell class and cell subclass

PDE9A HIPK3

5.38e-04176927a74217b7fa1032b918f00a3972dff5fab74671a
ToppCellNS-moderate-d_07-13-Epithelial-Ionocyte|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PDE9A SMAD9

5.44e-041779299500aed584f793aaf308f8afbf5d1c6a9b4ee55
ToppCellNS-moderate-d_16-33-Epithelial-Ionocyte|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PDE9A SMAD9

5.63e-04180928af8b4af2dc72223ac71fc027e0d4280c5dd81f8
ToppCellmoderate-Epithelial-Ionocyte|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

PDE9A SMAD9

6.20e-04189926011b747e27d61d222380a7bffdd921a68e9b657
ToppCellLPS_IL1RA_TNF-Hematopoietic_Myeloid-Dendritic_cells-pDC|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

NGLY1 TLR9

6.73e-04197928fa38fb95e285f9cc756ec4f32009be4ede09d3c
ToppCellLPS_only-Hematopoietic_Myeloid-Dendritic_cells-pDC|LPS_only / Treatment groups by lineage, cell group, cell type

NGLY1 TLR9

6.80e-0419892d205dfcfe1f20e1e21bf84759e723d9e6e610a5c
ToppCellSepsis-Int-URO-Others-RBC|Int-URO / Disease, condition lineage and cell class

NGLY1 TLR9

6.80e-041989229203aaa5c1844f72289e03f585cd5e7fc498a9a
ToppCellLPS_IL1RA_TNF-Hematopoietic_Myeloid-Dendritic_cells|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

NGLY1 TLR9

6.80e-0419892436f3a9ef31b0991765bb97c21960f20fa71d578
ToppCellLPS_IL1RA-Hematopoietic_Myeloid-Dendritic_cells|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

NGLY1 TLR9

6.80e-0419892ba3b97bb3e1533df758e845bde7d82eb1525b057
ToppCellSepsis-Int-URO-Others|Int-URO / Disease, condition lineage and cell class

NGLY1 TLR9

6.80e-041989267f721ea8e60042317ba12efd584f56b07cfb29d
ToppCell(06)_OLFM4+|World / shred by cell type by condition

PDE9A SORL1

6.87e-0419992c773b9180dbfec9c19d4098dd43332e6f6050372
ToppCell3'-Adult-LargeIntestine-Epithelial-Tuft-related-BEST4+_epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDE9A SORL1

6.87e-041999201d101b0fd5326947a9e5dddae6c2f93ab6e0a4d
ToppCellSepsis-Leuk-UTI-Others|Leuk-UTI / Disease, condition lineage and cell class

NGLY1 TLR9

6.87e-0419992e45fe91f1d1c47a305b0f39d808730723852af00
ToppCellLPS_IL1RA-Hematopoietic_Myeloid-Dendritic_cells-pDC|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

NGLY1 TLR9

6.87e-0419992f197ab861767ee06aa47b86c537fb3d8c2b2bc3e
ToppCellSepsis-Leuk-UTI-Others-RBC|Leuk-UTI / Disease, condition lineage and cell class

NGLY1 TLR9

6.87e-0419992d9b517199a646c9461c615412ad5b58cf4bed7c8
ToppCellControl_saline-Hematopoietic_Myeloid-Dendritic_cells-pDC|Control_saline / Treatment groups by lineage, cell group, cell type

NGLY1 TLR9

6.87e-041999234b95e27581bb127e0b921e9c068dc094cb86b37
ToppCell3'-Adult-LargeIntestine-Epithelial-Tuft-related|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDE9A SORL1

6.87e-04199926d439c0c5e6b72fcb8d4dc72e7445eb6a01fe095
ToppCellControl_saline-Hematopoietic_Myeloid-Dendritic_cells|Control_saline / Treatment groups by lineage, cell group, cell type

NGLY1 TLR9

6.93e-04200921559844b3116d41a69081e4ee89e64744a760181
ToppCellLPS_anti-TNF-Hematopoietic_Myeloid-Dendritic_cells-pDC|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

NGLY1 TLR9

6.93e-04200926a34e07e6d77fe3fdd9ff44c4b1e46a023f6d6a2
ComputationalGenes in the cancer module 26.

GAL3ST3 TLR9

5.26e-0320762MODULE_26
ComputationalBreast cancer expression clusters.

GAL3ST3 TLR9

5.77e-0321762MODULE_389
ComputationalGenes in the cancer module 207.

GAL3ST3 TLR9

6.24e-0322662MODULE_207
DrugN-acetyllactosamine

GAL3ST3 NGLY1 SORL1

2.99e-0516493CID000000245
Diseasebirth measurement, spontaneous preterm birth

SORL1 SMAD9

1.74e-06792EFO_0006917, EFO_0006921
DiseaseColorectal Carcinoma

TLR9 SORL1 SMAD9

1.01e-0370293C0009402
Diseaseheart rate

PDE9A SORL1

2.01e-0322592EFO_0004326
DiseaseAlzheimer disease, educational attainment

USP8 SORL1

2.42e-0324792EFO_0011015, MONDO_0004975
Diseaseamyloid-beta measurement

SORL1 SMAD9

4.91e-0335592EFO_0005194
DiseaseFEV/FEC ratio

PDE9A USP8 SORL1

5.00e-03122893EFO_0004713
Diseasememory performance

PDE9A SORL1

6.47e-0340992EFO_0004874

Protein segments in the cluster

PeptideGeneStartEntry
FANHFPTYVHCSFCR

ZNF280D

636

Q6N043
HYCDACQFSNRFPRY

NGLY1

281

Q96IV0
CVHDNYRNNPFHNFR

PDE9A

301

O76083
YRNNPFHNFRHCFCV

PDE9A

306

O76083
YNFVRAYECFQHRNH

HIPK3

256

Q9H422
CEHQFCYPRNFSAHF

GAL3ST3

101

Q96A11
PNCSRYFQFRCENGH

SORL1

1366

Q92673
FVQSRNCNYQHGFHP

SMAD9

356

O15198
DNHHFYNRNFCQGPT

TLR9

1016

Q9NR96
CNAPHLADYFNRNCY

USP8

796

P40818