Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	coumarin 7-hydroxylase activity	CYP2A6 CYP2A13	9.47e-06	3	36	2	GO:0008389
GeneOntologyMolecularFunction	arachidonate epoxygenase activity	CYP2A6 CYP2A13	8.51e-04	24	36	2	GO:0008392
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP2A6 CYP2A13	1.08e-03	27	36	2	GO:0008391
GeneOntologyMolecularFunction	steroid hydroxylase activity	CYP2A6 CYP2A13	1.71e-03	34	36	2	GO:0008395
GeneOntologyMolecularFunction	aromatase activity	CYP2A6 CYP2A13	1.81e-03	35	36	2	GO:0070330
GeneOntologyMolecularFunction	miRNA binding	PUM2 PUM1	3.38e-03	48	36	2	GO:0035198
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP2A6 CYP2A13	3.52e-03	49	36	2	GO:0016712
GeneOntologyMolecularFunction	ATP-dependent activity	ACSL4 AK9 ABCF1 DNAH6 SMCHD1	4.63e-03	614	36	5	GO:0140657
GeneOntologyMolecularFunction	regulatory RNA binding	PUM2 PUM1	5.58e-03	62	36	2	GO:0061980
GeneOntologyBiologicalProcess	transposition	MORC1 TEX15 PGBD5	9.05e-05	50	36	3	GO:0032196
GeneOntologyBiologicalProcess	phenylpropanoid metabolic process	CYP2A6 CYP2A13	1.32e-04	10	36	2	GO:0009698
GeneOntologyBiologicalProcess	coumarin metabolic process	CYP2A6 CYP2A13	1.32e-04	10	36	2	GO:0009804
GeneOntologyBiologicalProcess	multicellular organismal reproductive process	MORC1 ACSL4 KLHL10 TEX15 CNTLN PUM1 IFT88 SMCHD1 CNTRL	1.61e-04	1194	36	9	GO:0048609
GeneOntologyBiologicalProcess	positive regulation of RIG-I signaling pathway	PUM2 PUM1	1.61e-04	11	36	2	GO:1900246
GeneOntologyBiologicalProcess	positive regulation of miRNA-mediated gene silencing	PUM2 PUM1	1.93e-04	12	36	2	GO:2000637
GeneOntologyBiologicalProcess	positive regulation of post-transcriptional gene silencing by RNA	PUM2 PUM1	2.28e-04	13	36	2	GO:1900370
GeneOntologyBiologicalProcess	positive regulation of post-transcriptional gene silencing	PUM2 PUM1	2.28e-04	13	36	2	GO:0060148
GeneOntologyBiologicalProcess	gamete generation	MORC1 KLHL10 TEX15 CNTLN PUM1 IFT88 SMCHD1 CNTRL	2.36e-04	982	36	8	GO:0007276
GeneOntologyBiologicalProcess	regulatory ncRNA processing	PUM2 TEX15 PUM1	2.91e-04	74	36	3	GO:0070918
GeneOntologyBiologicalProcess	sexual reproduction	MORC1 KLHL10 TEX15 CNTLN FAM170A PUM1 IFT88 SMCHD1 CNTRL	3.26e-04	1312	36	9	GO:0019953
GeneOntologyBiologicalProcess	transposable element silencing by heterochromatin formation	MORC1 TEX15	4.45e-04	18	36	2	GO:0141005
GeneOntologyBiologicalProcess	3'-UTR-mediated mRNA destabilization	PUM2 PUM1	4.97e-04	19	36	2	GO:0061158
GeneOntologyCellularComponent	centrosome	ANKRD26 CNTLN IFT88 ZBED1 CCDC141 PTK2 CNTRL	3.51e-04	770	37	7	GO:0005813
GeneOntologyCellularComponent	sperm head-tail coupling apparatus	CNTLN IFT88	4.58e-04	18	37	2	GO:0120212
Domain	Pumilio_RNA-bd	PUM2 PUM1	3.82e-06	2	37	2	IPR033712
Domain	PUM-HD	PUM2 PUM1	1.14e-05	3	37	2	IPR033133
Domain	PUF	PUM2 PUM1	1.14e-05	3	37	2	PF00806
Domain	PUM_HD	PUM2 PUM1	1.14e-05	3	37	2	PS50303
Domain	Pumilio_RNA-bd_rpt	PUM2 PUM1	2.29e-05	4	37	2	IPR001313
Domain	Cyt_P450_E_grp-I_CYP2A-like	CYP2A6 CYP2A13	2.29e-05	4	37	2	IPR008067
Domain	PUM	PUM2 PUM1	2.29e-05	4	37	2	PS50302
Domain	Pumilio	PUM2 PUM1	2.29e-05	4	37	2	SM00025
Domain	Sel1-like	EEF2K IFT88	1.36e-04	9	37	2	IPR006597
Domain	-	MORC1 SMCHD1	7.09e-04	20	37	2	3.30.565.10
Domain	HATPase_C	MORC1 SMCHD1	7.83e-04	21	37	2	IPR003594
Domain	AAA+_ATPase	AK9 ABCF1 DNAH6	2.88e-03	144	37	3	IPR003593
Domain	AAA	AK9 ABCF1 DNAH6	2.88e-03	144	37	3	SM00382
Domain	Cyt_P450_E_grp-I	CYP2A6 CYP2A13	3.58e-03	45	37	2	IPR002401
Domain	Cyt_P450_CS	CYP2A6 CYP2A13	4.94e-03	53	37	2	IPR017972
Domain	CYTOCHROME_P450	CYP2A6 CYP2A13	5.69e-03	57	37	2	PS00086
Domain	-	CYP2A6 CYP2A13	5.89e-03	58	37	2	1.10.630.10
Domain	p450	CYP2A6 CYP2A13	5.89e-03	58	37	2	PF00067
Domain	Cyt_P450	CYP2A6 CYP2A13	6.29e-03	60	37	2	IPR001128
Domain	RhoGEF	ECT2L FGD6	8.01e-03	68	37	2	SM00325
Domain	DH_2	ECT2L FGD6	8.47e-03	70	37	2	PS50010
Domain	RhoGEF	ECT2L FGD6	8.47e-03	70	37	2	PF00621
Domain	DH-domain	ECT2L FGD6	8.71e-03	71	37	2	IPR000219
Domain	-	ECT2L FGD6	8.71e-03	71	37	2	1.20.900.10
Pathway	KEGG_MEDICUS_ENV_FACTOR_NNK_TO_DNA_ADDUCTS	CYP2A6 CYP2A13	3.52e-05	5	27	2	M47808
Pathway	REACTOME_CYP2E1_REACTIONS	CYP2A6 CYP2A13	1.92e-04	11	27	2	M27130
Pathway	REACTOME_CYP2E1_REACTIONS	CYP2A6 CYP2A13	2.30e-04	12	27	2	MM14847
Pathway	REACTOME_FATTY_ACIDS	CYP2A6 CYP2A13	5.30e-04	18	27	2	MM14841
Pathway	REACTOME_MET_ACTIVATES_PTK2_SIGNALING	LAMA4 PTK2	5.92e-04	19	27	2	MM15512
Pubmed	Interstrain differences in the expression and activity of Cyp2a5 in the mouse liver.	CYP2A6 CYP2A13	1.10e-06	2	37	2	28298240
Pubmed	Genetic polymorphisms for a phenobarbital-inducible cytochrome P-450 map to the Coh locus in mice.	CYP2A6 CYP2A13	1.10e-06	2	37	2	6309775
Pubmed	A Quantitative and Predictive Model for RNA Binding by Human Pumilio Proteins.	PUM2 PUM1	1.10e-06	2	37	2	31078383
Pubmed	Mechanism-based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo.	CYP2A6 CYP2A13	1.10e-06	2	37	2	21418183
Pubmed	Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes.	CYP2A6 CYP2A13	1.10e-06	2	37	2	22696418
Pubmed	Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.	CYP2A6 CYP2A13	1.10e-06	2	37	2	22262919
Pubmed	Suppressed hepatocyte proliferation via a ROS-HNE-P21 pathway is associated with nicotine- and cotinine-enhanced alcoholic fatty liver in mice.	CYP2A6 CYP2A13	1.10e-06	2	37	2	30876690
Pubmed	CYP2A5 induction and hepatocellular stress: an adaptive response to perturbations of heme homeostasis.	CYP2A6 CYP2A13	1.10e-06	2	37	2	21395539
Pubmed	Modulation of cytochrome P450 2A5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship.	CYP2A6 CYP2A13	1.10e-06	2	37	2	25635819
Pubmed	Principles of mRNA control by human PUM proteins elucidated from multimodal experiments and integrative data analysis.	PUM2 PUM1	1.10e-06	2	37	2	32753408
Pubmed	Species differences in coumarin metabolism: a molecular modelling evaluation of CYP2A interactions.	CYP2A6 CYP2A13	1.10e-06	2	37	2	12162851
Pubmed	Molecular characterization of the murine Coh locus: an amino acid difference at position 117 confers high and low coumarin 7-hydroxylase activity in P450coh.	CYP2A6 CYP2A13	1.10e-06	2	37	2	1302041
Pubmed	Structural alteration of mouse P450coh by mutation of glycine-207 to proline: spin equilibrium, enzyme kinetics, and heat sensitivity.	CYP2A6 CYP2A13	1.10e-06	2	37	2	8395817
Pubmed	Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins.	PUM2 PUM1	1.10e-06	2	37	2	12459267
Pubmed	Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice.	CYP2A6 CYP2A13	1.10e-06	2	37	2	25804444
Pubmed	PUMILIO proteins promote colorectal cancer growth via suppressing p21.	PUM2 PUM1	1.10e-06	2	37	2	35338151
Pubmed	Genetic variation between mice in their metabolism of coumarin and its derivatives.	CYP2A6 CYP2A13	1.10e-06	2	37	2	566237
Pubmed	Identification of diverse target RNAs that are functionally regulated by human Pumilio proteins.	PUM2 PUM1	1.10e-06	2	37	2	29165587
Pubmed	Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression.	CYP2A6 CYP2A13	1.10e-06	2	37	2	1520280
Pubmed	Effects of PUMILIO1 and PUMILIO2 knockdown on cardiomyogenic differentiation of human embryonic stem cells culture.	PUM2 PUM1	1.10e-06	2	37	2	32437472
Pubmed	Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model.	CYP2A6 CYP2A13	1.10e-06	2	37	2	19923441
Pubmed	Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.	CYP2A6 CYP2A13	1.10e-06	2	37	2	23917075
Pubmed	Effects of lipopolysaccharide-stimulated inflammation and pyrazole-mediated hepatocellular injury on mouse hepatic Cyp2a5 expression.	CYP2A6 CYP2A13	1.10e-06	2	37	2	12499123
Pubmed	Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5.	CYP2A6 CYP2A13	1.10e-06	2	37	2	30222954
Pubmed	Identification and characterization of a 44 kDa protein that binds specifically to the 3'-untranslated region of CYP2a5 mRNA: inducibility, subcellular distribution and possible role in mRNA stabilization.	CYP2A6 CYP2A13	1.10e-06	2	37	2	8611142
Pubmed	Up-regulation of CYP2A5 expression by porphyrinogenic agents in mouse liver.	CYP2A6 CYP2A13	1.10e-06	2	37	2	7543189
Pubmed	PUMILIO-mediated translational control of somatic cell cycle program promotes folliculogenesis and contributes to ovarian cancer progression.	PUM2 PUM1	1.10e-06	2	37	2	35507203
Pubmed	Bespoke RNA recognition by Pumilios.	PUM2 PUM1	1.10e-06	2	37	2	26517885
Pubmed	Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype.	CYP2A6 CYP2A13	1.10e-06	2	37	2	27902773
Pubmed	Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liver.	CYP2A6 CYP2A13	1.10e-06	2	37	2	22497566
Pubmed	Mouse Pum1 and Pum2 genes, members of the Pumilio family of RNA-binding proteins, show differential expression in fetal and adult hematopoietic stem cells and progenitors.	PUM2 PUM1	1.10e-06	2	37	2	12667987
Pubmed	Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer.	PUM2 PUM1	1.10e-06	2	37	2	12771951
Pubmed	Alternate modes of cognate RNA recognition by human PUMILIO proteins.	PUM2 PUM1	1.10e-06	2	37	2	21397187
Pubmed	Characterization and regulation of sex-specific mouse steroid hydroxylase genes.	CYP2A6 CYP2A13	1.10e-06	2	37	2	2372744
Pubmed	Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system.	PUM2 PUM1	1.10e-06	2	37	2	18776931
Pubmed	Coumarin toxicity in different strains of mice.	CYP2A6 CYP2A13	1.10e-06	2	37	2	665441
Pubmed	Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach.	CYP2A6 CYP2A13	1.10e-06	2	37	2	21473878
Pubmed	Characterization of RNP Networks of PUM1 and PUM2 Post-Transcriptional Regulators in TCam-2 Cells, a Human Male Germ Cell Model.	PUM2 PUM1	1.10e-06	2	37	2	32316190
Pubmed	Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene.	CYP2A6 CYP2A13	1.10e-06	2	37	2	24104196
Pubmed	The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis.	CYP2A6 CYP2A13	1.10e-06	2	37	2	7581481
Pubmed	The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference.	CYP2A6 CYP2A13	1.10e-06	2	37	2	26363552
Pubmed	Circadian Regulation of Hepatic Cytochrome P450 2a5 by Peroxisome Proliferator-Activated Receptor γ.	CYP2A6 CYP2A13	1.10e-06	2	37	2	30154104
Pubmed	Mouse liver P450Coh: genetic regulation of the pyrazole-inducible enzyme and comparison with other P450 isoenzymes.	CYP2A6 CYP2A13	1.10e-06	2	37	2	2712571
Pubmed	Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes.	CYP2A6 CYP2A13	3.30e-06	3	37	2	18602936
Pubmed	Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice.	CYP2A6 CYP2A13	3.30e-06	3	37	2	1417950
Pubmed	Expression of cytochrome P450 2A5 in a glucose-6-phosphate dehydrogenase-deficient mouse model of oxidative stress.	CYP2A6 CYP2A13	3.30e-06	3	37	2	18068688
Pubmed	Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.	CYP2A6 CYP2A13	3.30e-06	3	37	2	31645370
Pubmed	Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse.	CYP2A6 CYP2A13	3.30e-06	3	37	2	24045421
Pubmed	Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAs.	CYP2A6 CYP2A13	3.30e-06	3	37	2	32987105
Pubmed	Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA.	CYP2A6 CYP2A13	3.30e-06	3	37	2	3219345
Pubmed	Close linkage of the cytochrome P450IIA gene subfamily (Cyp2a) to Cyp2b and Coh on mouse chromosome 7.	CYP2A6 CYP2A13	3.30e-06	3	37	2	1973143
Pubmed	Antagonistic and cooperative AGO2-PUM interactions in regulating mRNAs.	PUM2 PUM1	3.30e-06	3	37	2	30333515
Pubmed	Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene.	CYP2A6 CYP2A13	3.30e-06	3	37	2	3346244
Pubmed	Zfp30, a KRAB domain containing zinc finger protein gene, maps to mouse chromosome 7.	CYP2A6 CYP2A13	3.30e-06	3	37	2	7849402
Pubmed	Alteration of the substrate specificity of mouse 2A P450s by the identity of residue-209: steroid-binding site and orientation.	CYP2A6 CYP2A13	3.30e-06	3	37	2	22217847
Pubmed	Mouse steroid 15 alpha-hydroxylase gene family: identification of type II P-450(15)alpha as coumarin 7-hydroxylase.	CYP2A6 CYP2A13	3.30e-06	3	37	2	2765478
Pubmed	Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome.	PUM2 PUM1	3.30e-06	3	37	2	33397688
Pubmed	NORAD: Defender of the Genome.	PUM2 PUM1	3.30e-06	3	37	2	27157388
Pubmed	A novel defensive mechanism against acetaminophen toxicity in the mouse lateral nasal gland: role of CYP2A5-mediated regulation of testosterone homeostasis and salivary androgen-binding protein expression.	CYP2A6 CYP2A13	3.30e-06	3	37	2	21252290
Pubmed	Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress.	CYP2A6 CYP2A13	3.30e-06	3	37	2	25478736
Pubmed	Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation.	CYP2A6 CYP2A13	3.30e-06	3	37	2	2415518
Pubmed	Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation.	CYP2A6 CYP2A13	3.30e-06	3	37	2	20840855
Pubmed	Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue.	CYP2A6 CYP2A13	3.30e-06	3	37	2	2733794
Pubmed	COP9 signalosome component CSN-5 stabilizes PUF proteins FBF-1 and FBF-2 in Caenorhabditis elegans germline stem and progenitor cells.	PUM2 PUM1	3.30e-06	3	37	2	38427913
Pubmed	Aryl hydrocarbon receptor nuclear translocator and upstream stimulatory factor regulate Cytochrome P450 2a5 transcription through a common E-box site.	CYP2A6 CYP2A13	3.30e-06	3	37	2	17466327
Pubmed	Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway.	CYP2A6 CYP2A13	3.30e-06	3	37	2	22552773
Pubmed	A trans-acting locus regulates transcriptional repression of the female-specific steroid 15 alpha-hydroxylase gene in male mice.	CYP2A6 CYP2A13	3.30e-06	3	37	2	8297477
Pubmed	Differential distribution of CYP2A6 and CYP2A13 in the human respiratory tract.	CYP2A6 CYP2A13	3.30e-06	3	37	2	22890016
Pubmed	Lack of the steroid 15 alpha-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily.	CYP2A6 CYP2A13	3.30e-06	3	37	2	8188299
Pubmed	Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.	CYP2A6 CYP2A13	3.30e-06	3	37	2	8484736
Pubmed	High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARα: a new model for steatohepatitis-associated fibrosis.	CYP2A6 CYP2A13	3.30e-06	3	37	2	32877213
Pubmed	Limited heme synthesis in porphobilinogen deaminase-deficient mice impairs transcriptional activation of specific cytochrome P450 genes by phenobarbital.	CYP2A6 CYP2A13	3.30e-06	3	37	2	11106424
Pubmed	Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes.	CYP2A6 CYP2A13	3.30e-06	3	37	2	8250953
Pubmed	Experimental nonalcoholic fatty liver disease in mice leads to cytochrome p450 2a5 upregulation through nuclear factor erythroid 2-like 2 translocation.	CYP2A6 CYP2A13	3.30e-06	3	37	2	24191237
Pubmed	Regulation of CYP2A5 gene by the transcription factor nuclear factor (erythroid-derived 2)-like 2.	CYP2A6 CYP2A13	3.30e-06	3	37	2	17303623
Pubmed	A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection.	PUM2 PUM1	3.30e-06	3	37	2	25340845
Pubmed	Generation and characterization of a novel Cyp2a(4/5)bgs-null mouse model.	CYP2A6 CYP2A13	3.30e-06	3	37	2	23073733
Pubmed	PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells.	PUM2 PUM1	3.30e-06	3	37	2	28232582
Pubmed	The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene.	CYP2A6 CYP2A13	3.30e-06	3	37	2	2703500
Pubmed	Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins.	PUM2 PUM1	3.30e-06	3	37	2	26724866
Pubmed	Pumilio facilitates miRNA regulation of the E2F3 oncogene.	PUM2 PUM1	3.30e-06	3	37	2	22345517
Pubmed	Analysis of RNA-protein interactions of mouse liver cytochrome P4502A5 mRNA.	CYP2A6 CYP2A13	6.60e-06	4	37	2	10215609
Pubmed	Mammalian Pum1 and Pum2 Control Body Size via Translational Regulation of the Cell Cycle Inhibitor Cdkn1b.	PUM2 PUM1	6.60e-06	4	37	2	30811992
Pubmed	Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver.	CYP2A6 CYP2A13	6.60e-06	4	37	2	9408084
Pubmed	A DNA methylation site in the male-specific P450 (Cyp 2d-9) promoter and binding of the heteromeric transcription factor GABP.	CYP2A6 CYP2A13	6.60e-06	4	37	2	7565685
Pubmed	Possible involvement of nuclear factor erythroid 2-related factor 2 in the gene expression of Cyp2b10 and Cyp2a5.	CYP2A6 CYP2A13	6.60e-06	4	37	2	24494203
Pubmed	Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP.	CYP2A6 CYP2A13	6.60e-06	4	37	2	10490589
Pubmed	Two steroid 15 alpha-hydroxylase genes and a homologous gene family in mice.	CYP2A6 CYP2A13	6.60e-06	4	37	2	1970547
Pubmed	Evidence for induced microsomal bilirubin degradation by cytochrome P450 2A5.	CYP2A6 CYP2A13	6.60e-06	4	37	2	16183037
Pubmed	Target RNA motif and target mRNAs of the Quaking STAR protein.	PUM2 PUM1	6.60e-06	4	37	2	16041388
Pubmed	The genes for mouse salivary androgen-binding protein (ABP) subunits alpha and gamma are located on chromosome 7.	CYP2A6 CYP2A13	6.60e-06	4	37	2	3569880
Pubmed	DNA sequence polymorphism in an androgen-regulated gene is associated with alteration in the encoded RNAs.	CYP2A6 CYP2A13	6.60e-06	4	37	2	6188152
Pubmed	Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models.	CYP2A6 CYP2A13	6.60e-06	4	37	2	22228748
Pubmed	PUM1 and PUM2 exhibit different modes of regulation for SIAH1 that involve cooperativity with NANOS paralogues.	PUM2 PUM1	1.10e-05	5	37	2	30269240
Pubmed	An Important Role of Pumilio 1 in Regulating the Development of the Mammalian Female Germline.	PUM2 PUM1	1.10e-05	5	37	2	27170441
Pubmed	Association of NAT2, GSTM1, GSTT1, CYP2A6, and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder cancer in Central China.	CYP2A6 CYP2A13	1.10e-05	5	37	2	19303722
Pubmed	CRY1/2 regulate rhythmic CYP2A5 in mouse liver through repression of E4BP4.	CYP2A6 CYP2A13	1.10e-05	5	37	2	37797722
Pubmed	Lyb-8.2: A new B cell antigen defined and characterized with a monoclonal antibody.	CYP2A6 CYP2A13	1.10e-05	5	37	2	6984010
Pubmed	Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARα-FGF21 axis.	CYP2A6 CYP2A13	1.65e-05	6	37	2	28131861
Pubmed	The RNA-binding protein Musashi-1 is produced in the developing and adult mouse eye.	PUM2 PUM1	1.65e-05	6	37	2	17768378
Interaction	CYP2A7 interactions	CYP2A6 CYP2A13	9.83e-06	3	37	2	int:CYP2A7
Cytoband	2p22-p21	PUM2 CAD	1.76e-05	8	37	2	2p22-p21
Cytoband	6q21	LAMA4 AK9 SOBP	6.54e-05	96	37	3	6q21
Cytoband	Ensembl 112 genes in cytogenetic band chr6q21	LAMA4 AK9 SOBP	1.30e-04	121	37	3	chr6q21
GeneFamily	Cytochrome P450 family 2	CYP2A6 CYP2A13	9.78e-04	35	24	2	1001
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ECT2L FGD6	3.44e-03	66	24	2	722
ToppCell	critical-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ECT2L AK9 IFT88 RFX3 DNAH6 CNTRL	1.40e-08	198	37	6	ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	ECT2L AK9 IFT88 RFX3 DNAH6	5.38e-07	193	37	5	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ECT2L AK9 IFT88 RFX3 DNAH6	5.52e-07	194	37	5	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANKRD26 ECT2L AK9 RFX3 DNAH6	5.95e-07	197	37	5	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_2\|367C / Donor, Lineage, Cell class and subclass (all cells)	KLHL10 CCDC141 SMCHD1 ICA1	8.62e-06	157	37	4	f1c6c313836352271033d23efd31b0f0a8a09e02
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ECT2L AK9 RFX3 DNAH6	1.44e-05	179	37	4	5e5f1cdf4aa66868d45b74ba91e20e848a3cbaff
ToppCell	pdx\|World / Sample and Cell Type and Tumor Cluster (all cells)	PUM1 SOBP CERS4 PTK2	1.68e-05	186	37	4	de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCell	pdx-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	PUM1 SOBP CERS4 PTK2	1.68e-05	186	37	4	0b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCell	droplet-Marrow-nan-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CNTLN NPEPPS ICA1 CNTRL	1.71e-05	187	37	4	14c239af77116d28d511dea754b6150d20488080
ToppCell	COPD-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	ECT2L AK9 RFX3 DNAH6	1.79e-05	189	37	4	3e77883db34722b9ce0a03ea74caefc92dc7feff
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A6 CYP2A13 RFX3 DNAH6	1.82e-05	190	37	4	2fdc024d3d673a0134b74b4c5a63afe924995730
ToppCell	Bronchial_Biopsy-Epithelial-Ciliated_1\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	ECT2L AK9 RFX3 DNAH6	1.90e-05	192	37	4	be592e661367affced9ebe80849b466e6adb3a34
ToppCell	Bronchial_Biopsy-Epithelial-Ciliated_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	ECT2L AK9 RFX3 DNAH6	1.94e-05	193	37	4	0b62a6ddd7c42efd9f39781971d1438501e1fa8d
ToppCell	Control-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	ECT2L AK9 RFX3 DNAH6	1.94e-05	193	37	4	0e37d454f3735edd936ee9a5f5f516ac3aad400e
ToppCell	Bronchial_Brush-Epithelial-Ciliated_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	AK9 IFT88 RFX3 DNAH6	1.98e-05	194	37	4	7a7ddccfe72a4a0dc4d1a5c809988f0069f9f1a3
ToppCell	Bronchial_Brush-Epithelial-Ciliated_1\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	AK9 IFT88 RFX3 DNAH6	1.98e-05	194	37	4	b4ce60c06568123008b1081d644733cb91c28f51
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ECT2L AK9 RFX3 DNAH6	2.02e-05	195	37	4	93b1559382a12cfb158aa5fac7386e38b4f87989
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ECT2L AK9 RFX3 DNAH6	2.02e-05	195	37	4	0e763f36786515698b593e5c93f6a56619c1242d
ToppCell	moderate-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ECT2L IFT88 RFX3 DNAH6	2.02e-05	195	37	4	3486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ECT2L AK9 RFX3 DNAH6	2.02e-05	195	37	4	9651ee03738226ee10e901f8b9ec6a417eb9c301
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ECT2L AK9 RFX3 DNAH6	2.02e-05	195	37	4	581b04220587e1d5198b1abd6965965ace7803e7
ToppCell	control-Epithelial-Ciliated\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ECT2L IFT88 RFX3 DNAH6	2.10e-05	197	37	4	d4e963c1f82996371bf3d63578ee9fce8e00c5a8
ToppCell	control-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ECT2L IFT88 RFX3 DNAH6	2.10e-05	197	37	4	e453d085182364ca347cbcc9dc995c62c3353016
ToppCell	(09)_Interm._secr.>cil.\|World / shred by cell type by condition	AK9 RFX3 DNAH6 CNTRL	2.23e-05	200	37	4	3305e14dba12e94da42f0414fdc7a2c8caf0a183
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL-Ependyma.Ccdc153_(Ccdc153)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ECT2L AK9 DNAH6	1.95e-04	136	37	3	67d736096d6b6ddb4722809557f5e987063b8d23
ToppCell	Substantia_nigra-Macroglia-CSF_related\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ECT2L AK9 DNAH6	1.95e-04	136	37	3	47663c5d81c766a333207a44fc5b58b07309ee76
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL-Ependyma.Ccdc153_(Ccdc153)--\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ECT2L AK9 DNAH6	1.95e-04	136	37	3	6d2e5b871f4cf8d64e6fe0be666fb3490797c635
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL-Ependyma.Ccdc153_(Ccdc153)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ECT2L AK9 DNAH6	1.95e-04	136	37	3	fd4269d194c7c11c6ab4383393a01efab05cbace
ToppCell	Substantia_nigra-Macroglia-CSF_related-EPENDYMAL\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	ECT2L AK9 DNAH6	1.95e-04	136	37	3	3f6cec8d52c84191f7f6e2dd4dc47524dfd5b21b
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CCDC141 SMCHD1 ICA1	2.75e-04	153	37	3	7480522a47e367f8facc4f5d599fbaf0b5ad4007
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	KLHL10 CCDC141 ICA1	2.81e-04	154	37	3	9200e2f1783e54cbc5dfc3b485b57c761af74a46
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	KLHL10 CCDC141 ICA1	2.81e-04	154	37	3	b16f3139ce50e70a6a2377b1da7d7877b4000ea1
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CCDC141 SMCHD1 ICA1	2.91e-04	156	37	3	53ded973358e3e48054130131e959f0d1f4ef60f
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CYP2A6 CYP2A13 PTK2	2.97e-04	157	37	3	c43f2e1ea53b375a7432f17f87cfef3b2261003d
ToppCell	NS-moderate-d_07-13-Epithelial-FOXN4+\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ANKRD26 AK9 DNAH6	2.97e-04	157	37	3	410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCell	367C-Lymphocytic-CD4_T-cell-Treg_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CCDC141 PGBD5 ICA1	3.08e-04	159	37	3	b05fda31b77536a1878f55d3199563b53f9420b2
ToppCell	10x5'-GI_large-bowel-Lymphocytic_T_CD4-Tregs\|GI_large-bowel / Manually curated celltypes from each tissue	KLHL10 DNAH6 ICA1	3.25e-04	162	37	3	9a5e65c45f73a6a685b8362aa2e6aea77181caa3
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_6\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CCDC141 SMCHD1 ICA1	3.43e-04	165	37	3	9ccce713d4122054bf4bef4a7126d90cf9141b84
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg-Treg_6\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CCDC141 SMCHD1 ICA1	3.43e-04	165	37	3	dbe231d00843cae917efd1abea6079ace3b45cdf
ToppCell	lung-Ciliated_Epithelia\|lung / shred on tissue and cell subclass	ECT2L AK9 DNAH6	3.56e-04	167	37	3	26cf1cfa58ee74794449a87eb19cd896e1ec8892
ToppCell	COVID-19_Moderate-Treg\|World / disease group, cell group and cell class	CCDC141 SMCHD1 ICA1	3.68e-04	169	37	3	27ad11239559b025bef582f89b2a83501d9d3993
ToppCell	5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AK9 RFX3 DNAH6	3.68e-04	169	37	3	fba841664939c771881ba97f14ef1df6635c04ff
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AK9 RFX3 DNAH6	3.68e-04	169	37	3	14aadc2d1bf66eb47dac33b4d61ddb3c942caa4f
ToppCell	Mild-Treg\|World / Disease group and Cell class	ACSL4 CCDC141 ICA1	3.75e-04	170	37	3	f3f177534badca34e1ae8671b7f583ee6688e14b
ToppCell	3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ECT2L RFX3 DNAH6	3.94e-04	173	37	3	c3762655caa79ac4879876f470d32578a3c93b01
ToppCell	droplet-Kidney-KIDNEY-30m-Mesenchymal-podocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKRD26 IFT88 SOBP	4.08e-04	175	37	3	31f0fb2e47e357dbf9c15436b7df85b3c370ded7
ToppCell	PSB-critical-LOC-Myeloid-Basophil\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ACSL4 CCDC141 RGS10	4.29e-04	178	37	3	45bdbb96094c97756e1b6eebd80eadd8472143f2
ToppCell	(05)_Ciliated-(4)_1wkpi\|(05)_Ciliated / shred by cell type and Timepoint	MORC1 AK9 MDM4	4.43e-04	180	37	3	85fc9b164147b28545e2397d32302eea03ef6346
ToppCell	RV\|World / Chamber and Cluster_Paper	LAMA4 ECT2L CCDC141	4.50e-04	181	37	3	bbe1e6e59d8889bd37d6e8303116cbdcafca7236
ToppCell	RSV-Healthy-5\|Healthy / Virus stimulation, Condition and Cluster	CCDC141 DNAH6 NPEPPS	4.72e-04	184	37	3	1e282d619ef8035437fabe0fd2aefda1c142f7f6
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_0\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CCDC141 SMCHD1 ICA1	4.72e-04	184	37	3	300edc4aa3ce55f309005c02c315fa0102ea9da7
ToppCell	RSV-Healthy-5\|RSV / Virus stimulation, Condition and Cluster	CCDC141 DNAH6 NPEPPS	4.72e-04	184	37	3	ba958f731de6c9eff60103d483e020e2c0c7af7c
ToppCell	3'_v3-bone_marrow-Myeloid_Dendritic-DC1\|bone_marrow / Manually curated celltypes from each tissue	FGD6 RGS10 PTK2	4.72e-04	184	37	3	ee295f6fa898da53883e1358b17f2c2dd177e9a7
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_0\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CCDC141 SMCHD1 ICA1	4.72e-04	184	37	3	8b397f9c18ed7abecdbcbd586d0ddadf07cf6e75
ToppCell	10x5'-blood-Lymphocytic_T_CD4-Tregs\|blood / Manually curated celltypes from each tissue	CCDC141 SMCHD1 ICA1	4.72e-04	184	37	3	22c15ce30171c687ab564f4383ae74d38b759272
ToppCell	(00)_Basal-(4)_1wkpi\|(00)_Basal / shred by cell type and Timepoint	MORC1 EEF2K ANXA7	4.79e-04	185	37	3	bf82ba905e5eee1c39a2731702071d3de10a78b8
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma\|TCGA-Prostate / Sample_Type by Project: Shred V9	RGS10 CERS4 ICA1	4.79e-04	185	37	3	9d53e0a92e4f99370be2e4be1dd737630796b1ca
ToppCell	pdx-Tumor_cells-T0\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	PUM1 CERS4 PTK2	4.79e-04	185	37	3	1d874608aa2062024323512f68889219471b2f00
ToppCell	Ciliated_cells-B-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	ECT2L RFX3 DNAH6	4.79e-04	185	37	3	f012c243343e1d1956db19b34d062e9b13de2b2a
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA4 CAD ICA1	4.87e-04	186	37	3	60830822d3de3147816693404fd03392e04c2b8e
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA4 CAD ICA1	4.87e-04	186	37	3	37860daeecd6d412bd3797f30496a56da667fbd1
ToppCell	droplet-Liver-Hepatocytes-18m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA4 CAD ICA1	4.87e-04	186	37	3	baebeffdd426ce767190ddefc857cc78e6a58d36
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma\|TCGA-Prostate / Sample_Type by Project: Shred V9	RGS10 CERS4 ICA1	4.95e-04	187	37	3	fa0452f3382c22c0391b241d06504fda3c6a19f0
ToppCell	3'_v3-bone_marrow-Lymphocytic_T_CD4-Tregs\|bone_marrow / Manually curated celltypes from each tissue	CCDC141 RGS10 ICA1	4.95e-04	187	37	3	bda716a64262325e6e68b281caf131f1840fd298
ToppCell	COVID-19_Mild-Neu_4\|COVID-19_Mild / 5 Neutrophil clusters in COVID-19 patients	EEF2K CPSF3 CNTRL	4.95e-04	187	37	3	714851e757c71c559ee6413a3f61d6c117c79ad2
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ACSL4 TEX15 CCDC141	4.95e-04	187	37	3	6ab51e17a7782c2ae6394cad813dc3a2cde70c89
ToppCell	human_hepatoblastoma-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	SOBP CERS4 PTK2	4.95e-04	187	37	3	f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCell	TCGA-Prostate-Primary_Tumor\|TCGA-Prostate / Sample_Type by Project: Shred V9	RGS10 CERS4 ICA1	4.95e-04	187	37	3	3e6a95c912dad5d61e10497ffaafd2b9027cd13a
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ACSL4 TEX15 CCDC141	4.95e-04	187	37	3	e176b5b051690f840f3b12c8f7c4cc10cbe2bbae
ToppCell	VE-Treg\|VE / Condition, Cell_class and T cell subcluster	CCDC141 SMCHD1 ICA1	5.02e-04	188	37	3	ef048517dfe2fc995d13eb1f08106a487354a4cc
ToppCell	VE-Treg-CD4_Treg\|VE / Condition, Cell_class and T cell subcluster	CCDC141 SMCHD1 ICA1	5.02e-04	188	37	3	fa88ceb336e30de3585e62608527a0d44df74190
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	CCDC141 SMCHD1 ICA1	5.02e-04	188	37	3	72be6fe654f3a5f654d3b9680145bce7ae9b721d
ToppCell	PBMC-Mild-Lymphocyte-T/NK-CD4+_T-Treg\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CCDC141 SMCHD1 ICA1	5.02e-04	188	37	3	9db3d3010cb8a1f3ee1cdccaf3cbaac3cf983fc5
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-OPC-like-OPC-like_Prolif-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AK9 ABCF1 TEX15	5.02e-04	188	37	3	0476d7ee3e0ce78c3c5b111e9ade01098f9ea7ec
ToppCell	Epithelial-Epithelial-D_(Ciliated)\|Epithelial / shred on cell class and cell subclass (v4)	AK9 IFT88 DNAH6	5.02e-04	188	37	3	8f30535a32968a81a304315a49c0d90a77d36948
ToppCell	PND07-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ECT2L AK9 DNAH6	5.10e-04	189	37	3	057d7a03fdbe779122b203619a6f947f49b84d28
ToppCell	(1)_T_CD4_reg\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	CCDC141 RGS10 ICA1	5.10e-04	189	37	3	28f28672fd260bb2a8d64152737a7242347c3174
ToppCell	PND07-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ECT2L AK9 DNAH6	5.10e-04	189	37	3	9f57a131902d23494bf389baf6e6e2d99f88b2c8
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-T_lymphocytic-regulatory_T_cell\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CCDC141 RGS10 ICA1	5.10e-04	189	37	3	9f6f6fe6e47f5c5fd48aab47a775f7bdd16de19c
ToppCell	MS-Treg-CD4_Treg\|MS / Condition, Cell_class and T cell subcluster	CCDC141 SMCHD1 ICA1	5.10e-04	189	37	3	b1310eed6113b3536868340a5b2b2587ad377fa9
ToppCell	MS-Treg\|MS / Condition, Cell_class and T cell subcluster	CCDC141 SMCHD1 ICA1	5.10e-04	189	37	3	3fa79242fb3dba4a3f52276da0124ba260423fb6
ToppCell	COVID-19_Mild-Treg\|COVID-19_Mild / Disease condition and Cell class	CCDC141 SMCHD1 ICA1	5.10e-04	189	37	3	f0fceb5f87ca260bfe038c0db3487a6d2e1b0a6e
ToppCell	PND07-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ECT2L AK9 DNAH6	5.10e-04	189	37	3	e443b02502edaefa94567a9e8af5756e8e11ff30
ToppCell	Epithelial_cells-Ciliated_cells-B\|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id	ECT2L RFX3 DNAH6	5.18e-04	190	37	3	426a4806f6e39d4d57c6746609d30bb3ca62df7d
ToppCell	PND03-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	AK9 IFT88 DNAH6	5.26e-04	191	37	3	bda8faf92495c8b362850c0aff4fc6fbdd9c563b
ToppCell	PND03-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	AK9 IFT88 DNAH6	5.26e-04	191	37	3	6880fb348bb0915db9a5da4f3566ca9ff93ed258
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ACSL4 CCDC141 SOBP	5.34e-04	192	37	3	cc9911e182a289779a2612bc213daae5607689e7
ToppCell	PND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ACSL4 TEX15 CCDC141	5.34e-04	192	37	3	7ccdb977320d09f21e70e7718ead73eeb56d0c48
ToppCell	PND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ACSL4 TEX15 CCDC141	5.34e-04	192	37	3	f206c015f091234e2c86dfa66926e97b2ea99690
ToppCell	multiciliated\|World / shred by cell class for turbinate	AK9 RFX3 DNAH6	5.34e-04	192	37	3	0f89ea0deb651ca11531c51ee94e0233608d22ea
ToppCell	PND28-Epithelial-Epithelial_Alveolar\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ACSL4 TEX15 CCDC141	5.34e-04	192	37	3	69963e8dc6d6368243e61da133484eb23225625a
ToppCell	PND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ACSL4 TEX15 CCDC141	5.34e-04	192	37	3	bfc68af68fdb99ddfe4add49671e4b4c26e6f962
ToppCell	PND03-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	AK9 IFT88 DNAH6	5.34e-04	192	37	3	b5cdc2dae3154b1e4ade88f841f38584402ffe33
ToppCell	ASK428-Epithelial-Ciliated\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	ECT2L AK9 RFX3	5.34e-04	192	37	3	356ebddd03aec341b79890977edb8ff0804999a1
ToppCell	IPF-Epithelial-Ciliated\|IPF / Disease state, Lineage and Cell class	ECT2L AK9 DNAH6	5.34e-04	192	37	3	354adc1354bf596fbc60dd45c0169688e6f45165
ToppCell	human_hepatoblastoma-Tumor_cells\|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)	SOBP CERS4 PTK2	5.42e-04	193	37	3	503a979328c68b096680b71359a26f02fafdff35
ToppCell	ASK452-Epithelial-Ciliated\|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq	ECT2L AK9 IFT88	5.42e-04	193	37	3	c0d10075862ac878aa05fc49c8b73e470783bf16
ToppCell	T_cells-CD56_bright_CD16-_NK_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	MORC1 CCDC141 FGD6	5.42e-04	193	37	3	826457e2aafdb61ead8a0a44d8cf9088d310684b
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ECT2L RFX3 DNAH6	5.42e-04	193	37	3	e1b76102f812c433195d1e8811fdd3293a7bc22e
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	PUM1 RFX3 PTK2	5.42e-04	193	37	3	e6a688bc834f845ff64dae1be64f073eec5091a1
Drug	nicotine imine	CYP2A6 CYP2A13	2.57e-06	2	37	2	ctd:C034629
Drug	propargyl ether	CYP2A6 CYP2A13	2.57e-06	2	37	2	ctd:C531209
Drug	alpha-nicotyrine	CYP2A6 CYP2A13	2.57e-06	2	37	2	ctd:C008615
Drug	Hempa	CYP2A6 CYP2A13	2.57e-06	2	37	2	ctd:D006492
Drug	N-nitrosoguvacoline	CYP2A6 CYP2A13	2.57e-06	2	37	2	ctd:C036676
Drug	2'-methoxyacetophenone	CYP2A6 CYP2A13	7.70e-06	3	37	2	CID000068481
Drug	Cyclobenzaprine hydrochloride [6202-23-9]; Up 200; 12.8uM; MCF7; HT_HG-U133A	ACSL4 TEX15 MDM4 RGS10 ICA1	1.53e-05	195	37	5	3268_UP
Drug	NMPA	CYP2A6 CYP2A13	1.54e-05	4	37	2	CID000132101
Drug	N'-nitrosoanatabine	CYP2A6 CYP2A13	1.54e-05	4	37	2	ctd:C032978
Drug	Dipyridamole [58-32-2]; Up 200; 8uM; MCF7; HT_HG-U133A	LAMA4 TEX15 CNTLN RFX3 RGS10	1.64e-05	198	37	5	5617_UP
Drug	N-methyl-N-2-(methylsulfinyl)ethylpropionic acid amide	CYP2A6 CYP2A13	2.56e-05	5	37	2	ctd:C062567
Drug	benzyl selenocyanate	CYP2A6 CYP2A13	2.56e-05	5	37	2	ctd:C054108
Drug	acenaphthene-1-ol	CYP2A6 CYP2A13	3.84e-05	6	37	2	ctd:C023723
Drug	AC1L196J	CYP2A6 CYP2A13	3.84e-05	6	37	2	CID000000415
Drug	menthofuran	CYP2A6 CYP2A13	3.84e-05	6	37	2	ctd:C054487
Drug	N'-nitrosoanabasine	CYP2A6 CYP2A13	3.84e-05	6	37	2	ctd:C010257
Drug	acenaphthene	CYP2A6 CYP2A13	5.37e-05	7	37	2	ctd:C042552
Drug	N-nitrosoguvacoline	CYP2A6 CYP2A13	9.18e-05	9	37	2	CID000062103
Drug	3-(methylnitrosamino)propionaldehyde	CYP2A6 CYP2A13	9.18e-05	9	37	2	CID000098533
Drug	acenaphthylene	CYP2A6 CYP2A13	9.18e-05	9	37	2	ctd:C042553
Drug	2,4-diaminopyrimidine	LAMA4 CYP2A6 PTK2	9.26e-05	54	37	3	CID000067431
Drug	D-702	CYP2A6 CYP2A13	1.40e-04	11	37	2	CID000054077
Disease	Neoplastic Cell Transformation	CYP2A13 PTK2 PGBD5	6.52e-04	139	36	3	C0007621
Disease	right ventricular systolic volume measurement	CCDC141 RGS10	8.40e-04	35	36	2	EFO_0021815
Disease	very long-chain saturated fatty acid measurement	NPEPPS CERS4	1.33e-03	44	36	2	EFO_0006796
Disease	X-12063 measurement	ANKRD26 PGBD5 ICA1	1.51e-03	186	36	3	EFO_0021283
Disease	hepatocellular carcinoma (implicated_via_orthology)	CAD PTK2	1.64e-03	49	36	2	DOID:684 (implicated_via_orthology)
Disease	obesity (implicated_via_orthology)	ANKRD26 PUM2 PUM1	2.28e-03	215	36	3	DOID:9970 (implicated_via_orthology)
Disease	Unipolar Depression	MORC1 ACSL4 MDM4	3.85e-03	259	36	3	C0041696
Disease	Glioblastoma	MDM4 PTK2	4.20e-03	79	36	2	C0017636
Disease	Giant Cell Glioblastoma	MDM4 PTK2	4.74e-03	84	36	2	C0334588

Protein segments in the cluster

Peptide	Gene	Start	Entry
IYKNVMSKVQEMNYI	ACSL4	381	O60488
GNYMTFKKMYQQKQK	ABCF1	531	Q8NE71
LEACKMVNYMQYQQV	CERS4	246	Q9HA82
LNQMQYEYTELKKQM	CNTRL	2126	Q7Z7A1
VAVKEKSQYEQMYQK	CNTLN	1201	Q9NXG0
YLQLNTEQMYNSLMK	CYP2A6	46	P11509
KKCMAVYQTYVNAMN	CPSF3	276	Q9UKF6
KYKGYIDQMKQNITM	ECT2L	746	Q008S8
LVQIKQMFAQMYQKT	ANXA7	451	P20073
MEQKYQNEQVKVNKY	ANKRD26	1111	Q9UPS8
MFQKLQDQIFNLMKY	RGS10	126	O43665
MKDQYANYVVQKMID	PUM2	996	Q8TB72
KLKMCFNQIQNTYMV	MORC1	861	Q86VD1
FNQIQNTYMVQYEKK	MORC1	866	Q86VD1
MVKQLYDQQEQHMVY	MDM4	61	O15151
MNMYLTKFQQKNAAA	NPEPPSL1	461	A6NEC2
MKDQYANYVVQKMID	PUM1	1116	Q14671
KNMVVQTNMYAKKFQ	PGBD5	136	Q8N414
GNIVTQMYKLMEQYQ	DNAH6	751	Q9C0G6
KMNMGNIYLKQRNYS	IFT88	236	Q13099
AEYFMNNVKMNDYVK	KLHL10	236	Q6JEL2
KYQIQQVDMYAEKMQ	CCDC141	941	Q6ZP82
YLQLNTEQMYNSLMK	CYP2A13	46	Q16696
MEAMKGRLANQYYQK	EEF2K	701	O00418
MNMYLTKFQQKNAAT	NPEPPS	461	P55786
MRDKIQEINNKMLYY	LAMA4	391	Q16363
YAQDKSVVNKMQQKY	ICA1	16	Q05084
VIKNVQMVNKYMQTY	AK9	1596	Q5TCS8
QMVNKYMQTYLERIK	AK9	1601	Q5TCS8
FMFYNDVKKQQQMAA	SMCHD1	1611	A6NHR9
YMAMRQQPMQQKQRY	RFX3	271	P48380
QYVMTSLQQEYKKQM	PTK2	1006	Q05397
NQYKMDIFYKETQAN	SOBP	256	A7XYQ1
MKIYYMQVQMNKGVA	FAM170A	126	A1A519
MKQGDNFQKLMQIQY	FGD6	1061	Q6ZV73
QLRKMGYKTIMVNYN	CAD	961	P27708
NFMQQKAFKYMSVIQ	XKR3	156	Q5GH77
EILKKYFQMLQDNNM	TEX15	2016	Q9BXT5
AVAMYMLYEKQKQQN	ZBED1	326	O96006
KQMYKQEMKTNYETL	ZNF425	31	Q6IV72