Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	brain-derived neurotrophic factor binding	HAP1 FSTL4	8.54e-05	4	76	2	GO:0048403
GeneOntologyCellularComponent	actin cytoskeleton	FLII XIRP2 HAP1 FMN1 CARMIL1 MYO18A ADAM17 ACTN3 MYZAP CIT NCOA5	9.24e-06	576	78	11	GO:0015629
GeneOntologyCellularComponent	cell surface	CXCR5 LRFN1 LRFN4 LRFN2 PLPPR4 PPFIA2 TRPC4 MYO18A ADAM17 ADGRV1 ITGAL KIT TLR8 MAP3K5 TFRC	1.29e-05	1111	78	15	GO:0009986
GeneOntologyCellularComponent	plasma membrane bounded cell projection cytoplasm	HAP1 BBS7 CEP162 KIF4A TEKT5 CCDC40 KIF1C	1.81e-04	317	78	7	GO:0032838
GeneOntologyCellularComponent	cytoplasmic region	HAP1 BBS7 CEP162 KIF4A TEKT5 CCDC40 KIF1C	3.92e-04	360	78	7	GO:0099568
GeneOntologyCellularComponent	supramolecular fiber	CENPE XIRP2 FMN1 CEP162 CARMIL1 MYO18A KIF4A SYNC ACTN3 MYZAP CAMSAP1 TEKT5 KIF1C	3.93e-04	1179	78	13	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	CENPE XIRP2 FMN1 CEP162 CARMIL1 MYO18A KIF4A SYNC ACTN3 MYZAP CAMSAP1 TEKT5 KIF1C	4.19e-04	1187	78	13	GO:0099081
GeneOntologyCellularComponent	Golgi transport complex	COG7 COG5	6.07e-04	10	78	2	GO:0017119
GeneOntologyCellularComponent	anchoring junction	FLII XIRP2 FMN1 TRPC4 FRMPD2 LAMA3 ADAM17 ACTN3 MYZAP ITGAL KIT	9.62e-04	976	78	11	GO:0070161
HumanPheno	Recurrent skin infections	JAK3 LAMA3 ADAM17 LYST TLR8 STAT1 TFRC	1.33e-05	159	27	7	HP:0001581
HumanPheno	Chronic oral candidiasis	JAK3 TLR8 STAT1 TFRC	1.79e-05	31	27	4	HP:0009098
HumanPheno	Abnormal tendency to infections of the skin	JAK3 LAMA3 ADAM17 LYST TLR8 STAT1 TFRC	1.98e-05	169	27	7	HP:0002727
Domain	Cys-rich_flank_reg_C	LRIG2 LRFN1 LRFN4 LRFN2 TLR8	3.28e-05	90	76	5	IPR000483
Domain	LRRCT	LRIG2 LRFN1 LRFN4 LRFN2 TLR8	3.28e-05	90	76	5	SM00082
Domain	LRR_8	LRIG2 FLII LRFN1 LRFN4 LRFN2 TLR8	6.94e-05	171	76	6	PF13855
Domain	Leu-rich_rpt_typical-subtyp	LRIG2 FLII LRFN1 LRFN4 LRFN2 TLR8	8.40e-05	177	76	6	IPR003591
Domain	LRR_TYP	LRIG2 FLII LRFN1 LRFN4 LRFN2 TLR8	8.40e-05	177	76	6	SM00369
Domain	Leu-rich_rpt	LRIG2 FLII LRFN1 LRFN4 LRFN2 CARMIL1 TLR8	1.17e-04	271	76	7	IPR001611
Domain	-	LRIG2 FLII LRFN1 LRFN4 LRFN2 CARMIL1 TLR8	3.29e-04	321	76	7	3.80.10.10
Domain	L_dom-like	LRIG2 FLII LRFN1 LRFN4 LRFN2 CARMIL1 TLR8	3.74e-04	328	76	7	IPR032675
Domain	IGc2	LRIG2 LRFN1 LRFN4 LRFN2 FSTL4 KIT	3.90e-04	235	76	6	SM00408
Domain	Ig_sub2	LRIG2 LRFN1 LRFN4 LRFN2 FSTL4 KIT	3.90e-04	235	76	6	IPR003598
Domain	TMC	TMC7 TMC3	4.50e-04	8	76	2	PF07810
Domain	TMC	TMC7 TMC3	4.50e-04	8	76	2	IPR012496
Domain	Kinesin_motor_CS	CENPE KIF4A KIF1C	6.18e-04	41	76	3	IPR019821
Domain	Kinesin-like_fam	CENPE KIF4A KIF1C	7.11e-04	43	76	3	IPR027640
Domain	KINESIN_MOTOR_1	CENPE KIF4A KIF1C	7.61e-04	44	76	3	PS00411
Domain	-	CENPE KIF4A KIF1C	7.61e-04	44	76	3	3.40.850.10
Domain	Kinesin_motor_dom	CENPE KIF4A KIF1C	7.61e-04	44	76	3	IPR001752
Domain	Kinesin	CENPE KIF4A KIF1C	7.61e-04	44	76	3	PF00225
Domain	KINESIN_MOTOR_2	CENPE KIF4A KIF1C	7.61e-04	44	76	3	PS50067
Domain	KISc	CENPE KIF4A KIF1C	7.61e-04	44	76	3	SM00129
Domain	Ig_I-set	LRIG2 LRFN1 LRFN4 LRFN2 FSTL4	1.06e-03	190	76	5	IPR013098
Domain	I-set	LRIG2 LRFN1 LRFN4 LRFN2 FSTL4	1.06e-03	190	76	5	PF07679
Domain	LRR	LRIG2 FLII LRFN1 LRFN2 TLR8	1.37e-03	201	76	5	PS51450
Domain	LRR_1	LRIG2 FLII LRFN4 LRFN2 TLR8	1.99e-03	219	76	5	PF00560
Pathway	REACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES	LRFN1 LRFN4 LRFN2	8.76e-05	20	62	3	MM15485
Pathway	REACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES	LRFN1 LRFN4 LRFN2	1.02e-04	21	62	3	M27736
Pubmed	The SALM/Lrfn family of leucine-rich repeat-containing cell adhesion molecules.	LRFN1 LRFN4 LRFN2	4.68e-08	4	80	3	21736948
Pubmed	Comparative analysis of structure, expression and PSD95-binding capacity of Lrfn, a novel family of neuronal transmembrane proteins.	LRFN1 LRFN4 LRFN2	4.07e-07	7	80	3	16828986
Pubmed	A novel family of adhesion-like molecules that interacts with the NMDA receptor.	LRFN1 LRFN4 LRFN2	4.07e-07	7	80	3	16495444
Pubmed	Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo.	LRIG2 LRFN1 LRFN4 LRFN2	1.14e-06	34	80	4	18848646
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	LRIG2 FLII LRFN1 PLPPR4 CENPE TRPC4 KIF4A GIGYF2 CAMSAP1 CIT PCDH8 MAP3K5	2.03e-06	963	80	12	28671696
Pubmed	A common mutation in the COG7 gene with a consistent phenotype including microcephaly, adducted thumbs, growth retardation, VSD and episodes of hyperthermia.	COG7 COG5	5.23e-06	2	80	2	17356545
Pubmed	Role of Janus kinase 3 in mast cell-mediated innate immunity against gram-negative bacteria.	JAK3 KIT	5.23e-06	2	80	2	11520465
Pubmed	Tumor necrosis factor-alpha-converting enzyme controls surface expression of c-Kit and survival of embryonic stem cell-derived mast cells.	ADAM17 KIT	5.23e-06	2	80	2	14625290
Pubmed	Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in hematological parameters.	KIT TFRC	5.23e-06	2	80	2	21553221
Pubmed	Cog5-Cog7 crystal structure reveals interactions essential for the function of a multisubunit tethering complex.	COG7 COG5	5.23e-06	2	80	2	25331899
Pubmed	Increased transferrin receptor expression following 11q23 deletion as a mechanism of malignant progression in chronic lymphocytic leukemia.	ATM TFRC	5.23e-06	2	80	2	16326028
Pubmed	Apoptosis-induced ectodomain shedding of hypoxia-regulated carbonic anhydrase IX from tumor cells: a double-edged response to chemotherapy.	CA9 ADAM17	5.23e-06	2	80	2	26993100
Pubmed	Dysregulation of the DNA Damage Response and KMT2A Rearrangement in Fetal Liver Hematopoietic Cells.	KMT2A ATM	5.23e-06	2	80	2	26657054
Pubmed	A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival.	JAK3 MYO18A	5.23e-06	2	80	2	10733938
Pubmed	Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML.	KMT2A ATM	1.57e-05	3	80	2	27625305
Pubmed	Mechanostress resistance involving formin homology proteins: G- and F-actin homeostasis-driven filament nucleation and helical polymerization-mediated actin polymer stabilization.	FMN1 ACTN3	1.57e-05	3	80	2	30309655
Pubmed	Impact of FLT3 mutations and promyelocytic leukaemia-breakpoint on clinical characteristics and prognosis in acute promyelocytic leukaemia.	KMT2A KIT	1.57e-05	3	80	2	16029447
Pubmed	Synaptic adhesion-like molecules (SALMs) promote neurite outgrowth.	LRFN1 LRFN4	1.57e-05	3	80	2	18585462
Pubmed	CRISPR Gene Editing of Murine Blood Stem and Progenitor Cells Induces MLL-AF9 Chromosomal Translocation and MLL-AF9 Leukaemogenesis.	KMT2A KIT	1.57e-05	3	80	2	32549410
Pubmed	C/EBP{delta} and STAT-1 are required for TLR8 transcriptional activity.	TLR8 STAT1	1.57e-05	3	80	2	20829351
Pubmed	Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550).	JAK3 STAT1	1.57e-05	3	80	2	21383241
Pubmed	Estrogen-regulated STAT1 activation promotes TLR8 expression to facilitate signaling via microRNA-21 in systemic lupus erythematosus.	TLR8 STAT1	1.57e-05	3	80	2	28039018
Pubmed	ADAM10 mediates shedding of carbonic anhydrase IX ectodomain non‑redundantly to ADAM17.	CA9 ADAM17	1.57e-05	3	80	2	36524367
Pubmed	Genetic analysis of the subunit organization and function of the conserved oligomeric golgi (COG) complex: studies of COG5- and COG7-deficient mammalian cells.	COG7 COG5	1.57e-05	3	80	2	16051600
Pubmed	Long non-coding RNA TLR8-AS1 induces preeclampsia through increasing TLR8/STAT1 axis.	TLR8 STAT1	1.57e-05	3	80	2	37199563
Pubmed	Site of beige (bg) and leaden (ln) pigment gene expression determined by recombinant embryonic skin grafts and aggregation mouse chimaeras employing sash (Wsh) homozygotes.	KIT LYST	1.57e-05	3	80	2	3910518
Pubmed	FLII and MLL1 Cooperatively Regulate Aryl Hydrocarbon Receptor-Mediated Transcription in ARPE-19 Cells.	FLII KMT2A	1.57e-05	3	80	2	34698116
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	FLII NRIP1 CENPE XIRP2 CARMIL1 KMT2A GIGYF2 ATM	1.94e-05	497	80	8	36774506
Pubmed	SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion.	LRFN1 LRFN4 LRFN2	2.60e-05	25	80	3	27480238
Pubmed	Coexpression of CD71 and CD117 Identifies an Early Unipotent Neutrophil Progenitor Population in Human Bone Marrow.	KIT TFRC	3.13e-05	4	80	2	32814027
Pubmed	Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development.	KMT2A KIT	3.13e-05	4	80	2	27396339
Pubmed	TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells.	PLEKHM2 ITGAL	3.13e-05	4	80	2	29150602
Pubmed	Regulation of the Jak/STAT signalling pathway.	JAK3 STAT1	3.13e-05	4	80	2	8593242
Pubmed	Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation.	CENPE KIF4A	3.13e-05	4	80	2	15297875
Pubmed	Identification of a novel p53-dependent activation pathway of STAT1 by antitumour genotoxic agents.	ATM STAT1	3.13e-05	4	80	2	17992189
Pubmed	Target silencing of components of the conserved oligomeric Golgi complex impairs HIV-1 replication.	COG7 COG5	3.13e-05	4	80	2	25179963
Pubmed	STAT protein recruitment and activation in c-Kit deletion mutants.	KIT STAT1	3.13e-05	4	80	2	10358045
Pubmed	Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.	LRIG2 LRFN1 LRFN4 LRFN2 FSTL4	3.74e-05	162	80	5	25826454
Pubmed	CUEDC2, a novel interacting partner of the SOCS1 protein, plays important roles in the leukaemogenesis of acute myeloid leukaemia.	JAK3 ATM KIT MAP3K5	5.00e-05	87	80	4	29991678
Pubmed	Activating mutations in human acute megakaryoblastic leukemia.	JAK3 KIT	5.20e-05	5	80	2	18755984
Pubmed	Stat1 associates with c-kit and is activated in response to stem cell factor.	KIT STAT1	5.20e-05	5	80	2	9355737
Pubmed	Roles of TRP14, a thioredoxin-related protein in tumor necrosis factor-alpha signaling pathways.	KMT2A MAP3K5	5.20e-05	5	80	2	14607843
Pubmed	Direct interaction between Kit and the interleukin-7 receptor.	JAK3 KIT	5.20e-05	5	80	2	17554063
Pubmed	Enhanced expression of Janus kinase-signal transducer and activator of transcription pathway members in human diabetic nephropathy.	JAK3 STAT1	5.20e-05	5	80	2	19017763
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	FLII RALGAPB MYO18A KMT2A GIGYF2 SSR3 STAT1 KIF1C	7.38e-05	601	80	8	33658012
Pubmed	CXCL13/CXCR5 signaling enhances BCR-triggered B-cell activation by shaping cell dynamics.	CXCR5 ITGAL	7.79e-05	6	80	2	21659539
Pubmed	RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1.	ITGAL TFRC	7.79e-05	6	80	2	14722085
Pubmed	Comprehensive analysis of cooperative gene mutations between class I and class II in de novo acute myeloid leukemia.	KMT2A KIT	7.79e-05	6	80	2	19309322
Pubmed	The JAK/STAT pathway is not sufficient to sustain the antiproliferative response in an interferon-resistant human melanoma cell line.	JAK3 STAT1	7.79e-05	6	80	2	12777975
Pubmed	KIF14 and citron kinase act together to promote efficient cytokinesis.	KIF4A CIT	7.79e-05	6	80	2	16431929
Pubmed	Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype.	KMT2A KIT	7.79e-05	6	80	2	16076867
Pubmed	Paramyxovirus Sendai virus V protein counteracts innate virus clearance through IRF-3 activation, but not via interferon, in mice.	LYST STAT1	7.79e-05	6	80	2	17027894
Pubmed	All kinesin superfamily protein, KIF, genes in mouse and human.	CENPE KIF4A KIF1C	8.61e-05	37	80	3	11416179
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ZFYVE28 ZNF529 CCDC40 NCOA5	8.94e-05	101	80	4	10997877
Pubmed	The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs).	JAK3 STAT1	1.09e-04	7	80	2	9342212
Pubmed	JAK/STAT signaling by cytokine receptors.	JAK3 STAT1	1.09e-04	7	80	2	9638363
Pubmed	Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis.	TMC7 TMC3	1.45e-04	8	80	2	12906855
Pubmed	JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway.	JAK3 STAT1	1.45e-04	8	80	2	19414010
Pubmed	The binary interacting network of the conserved oligomeric Golgi tethering complex.	COG7 COG5	1.45e-04	8	80	2	15047703
Pubmed	Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.	LRIG2 ADAM17	1.45e-04	8	80	2	26651291
Pubmed	TMC and EVER genes belong to a larger novel family, the TMC gene family encoding transmembrane proteins.	TMC7 TMC3	1.45e-04	8	80	2	12812529
Pubmed	Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function.	COG7 COG5	1.45e-04	8	80	2	11980916
Pubmed	COG Complex Complexities: Detailed Characterization of a Complete Set of HEK293T Cells Lacking Individual COG Subunits.	COG7 COG5	1.45e-04	8	80	2	27066481
Pubmed	Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp.	COG7 COG5	1.45e-04	8	80	2	11929878
Pubmed	Genetically determined murine models of immunodeficiency.	KIT LYST	1.45e-04	8	80	2	3297105
Pubmed	A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins.	FLII MYO18A ACTN3	1.55e-04	45	80	3	22114352
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DENND1B CEP162 CARMIL1 RALGAPB KMT2A GIGYF2 CAMSAP1 LYST KIF1C	1.62e-04	861	80	9	36931259
Pubmed	The Jak-STAT pathway.	JAK3 STAT1	1.86e-04	9	80	2	10781830
Pubmed	Mutational profiling of kinases in human tumours of pancreatic origin identifies candidate cancer genes in ductal and ampulla of vater carcinomas.	ATM KIT	1.86e-04	9	80	2	20838624
Pubmed	The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses.	JAK3 STAT1	1.86e-04	9	80	2	23435120
Pubmed	Cutting edge: nitrogen bisphosphonate-induced inflammation is dependent upon mast cells and IL-1.	KIT LYST	1.86e-04	9	80	2	22387558
Pubmed	Citron Kinase Deficiency Leads to Chromosomal Instability and TP53-Sensitive Microcephaly.	ATM CIT	1.86e-04	9	80	2	28199840
Pubmed	The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway.	JAK3 STAT1	1.86e-04	9	80	2	10506573
Pubmed	The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK/STAT and ERK1/2 pathways.	JAK3 STAT1	1.86e-04	9	80	2	17938255
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	JAK3 FLII LRFN1 PLEKHM2 POMGNT1 CAMSAP1 CIT LYST ADCY9 MAP3K5	2.21e-04	1105	80	10	35748872
Pubmed	Cytokines, Jaks, Stats, health and disease.	JAK3 STAT1	2.32e-04	10	80	2	10200816
Pubmed	TANGO6 regulates cell proliferation via COPI vesicle-mediated RPB2 nuclear entry.	KIT TFRC	2.32e-04	10	80	2	38490996
Pubmed	Nef, the shuttling molecular adaptor of HIV, influences the cytokine network.	ADAM17 STAT1	2.84e-04	11	80	2	25529283
Pubmed	Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells.	JAK3 KIT	2.84e-04	11	80	2	23603794
Pubmed	Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference.	CENPE KIF4A	2.84e-04	11	80	2	15843429
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	CENPE COG7 SERPINB12 CARMIL1 KIF4A ATM COG5 KIF1C TFRC ZNF331	3.14e-04	1155	80	10	20360068
Pubmed	Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins.	JAK3 KIT	3.40e-04	12	80	2	10872802
Pubmed	Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.	PLPPR4 CARMIL1 RALGAPB KIT PCDH8 ADCY9	3.49e-04	405	80	6	38187761
Pubmed	Sdmg1 is a conserved transmembrane protein associated with germ cell sex determination and germline-soma interactions in mice.	KIT TFRC	4.01e-04	13	80	2	18321981
Pubmed	RNF38 suppress growth and metastasis via ubiquitination of ACTN4 in nasopharyngeal carcinoma.	FLII SERPINB12 MYO18A	4.02e-04	62	80	3	35568845
Pubmed	Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions.	CA9 JAK3 ATM CIT MAP3K5	4.49e-04	276	80	5	28319085
Pubmed	Molecular dissection of plasmacytoid dendritic cell activation in vivo during a viral infection.	ITGAL STAT1	4.67e-04	14	80	2	30131424
Pubmed	Mutations in mice that influence natural killer (NK) cell activity.	KIT LYST	4.67e-04	14	80	2	6971254
Pubmed	Platelet storage pool deficiency in mouse pigment mutations associated with seven distinct genetic loci.	KIT LYST	5.38e-04	15	80	2	6696991
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	LRIG2 LAMA3 ADAM17 TFRC	5.70e-04	164	80	4	32409323
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	FLII BBS7 SERPINB12 GIGYF2 NOC4L CIT STAT1 TFRC NCOA5	5.73e-04	1024	80	9	24711643
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	NRIP1 LRFN2 DENND1B PPFIA2 CARMIL1 FRMPD2 RALGAPB LAMA3 ADGRV1 MCTP2 ZNF331	5.93e-04	1489	80	11	28611215
Pubmed	Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.	ADGRV1 ADCY9	6.14e-04	16	80	2	17567809
Pubmed	Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting.	CXCR5 JAK3	6.14e-04	16	80	2	10687308
Pubmed	Breakdown of the reciprocal stabilization of QBRICK/Frem1, Fras1, and Frem2 at the basement membrane provokes Fraser syndrome-like defects.	TRPC4 LAMA3	6.14e-04	16	80	2	16880404
Pubmed	Engagement of the G3BP2-TRIM25 Interaction by Nucleocapsid Protein Suppresses the Type I Interferon Response in SARS-CoV-2-Infected Cells.	NRIP1 SERPINB12 ATM	7.30e-04	76	80	3	36560452
Pubmed	A Positive Regulatory Feedback Loop between EKLF/KLF1 and TAL1/SCL Sustaining the Erythropoiesis.	JAK3 STAT1	8.71e-04	19	80	2	34360789
Pubmed	A human MAP kinase interactome.	MYO18A LAMA3 GIGYF2 COG5 STAT1 MAP3K5	9.06e-04	486	80	6	20936779
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	LRIG2 PLEKHM2 POMGNT1 ADAM17 LYST FAM135A	1.09e-03	504	80	6	34432599
Pubmed	Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study.	NRIP1 ATM STAT1	1.15e-03	89	80	3	18950845
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	LRIG2 LRFN1 LRFN4 LRFN2 FSTL4	1.65e-04	161	58	5	593
GeneFamily	Components of oligomeric golgi complex	COG7 COG5	2.80e-04	8	58	2	493
GeneFamily	Transmembrane channel likes	TMC7 TMC3	2.80e-04	8	58	2	1135
GeneFamily	Kinesins\|Pleckstrin homology domain containing	CENPE KIF4A KIF1C	4.31e-04	46	58	3	622
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	CXCR5 ADAM17 ITGAL KIT TLR8 TFRC	1.60e-03	394	58	6	471
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CA9 HAP1 SPOCK3 LAMA3 KIT MCTP2 PCDH8 PREX2	2.92e-09	200	80	8	7e51715525fdb001b7042b2bfcb9de81ecb5e4ee
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HAP1 SPOCK3 LAMA3 KIT MCTP2 PCDH8 PREX2	5.64e-08	192	80	7	6a252e298f8a454623fa9c1c893a7a45a886d694
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CHRM2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CA9 HAP1 SPOCK3 LAMA3 KIT PCDH8 PREX2	7.45e-08	200	80	7	501a3b93624df463458a35d3e6648d4ccc941724
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CHRM2-L1-3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CA9 HAP1 SPOCK3 LAMA3 KIT PCDH8 PREX2	7.45e-08	200	80	7	d1f36a8232411933b1494168ec912fd0e5246428
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HAP1 SPOCK3 LAMA3 KIT MCTP2 PCDH8 PREX2	7.45e-08	200	80	7	75649534a98bc738fca62d071de0978dc61eb24f
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HAP1 LAMA3 KIT MCTP2 PCDH8 PREX2	9.16e-07	181	80	6	35bcdcd2651149692e5b150e887c0f450c81d2d4
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L3_VIP_CBLN1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CA9 HAP1 SPOCK3 LAMA3 MCTP2 PCDH8	9.16e-07	181	80	6	7846c7b33d1b89364c5a704edaa86520db731c89
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HAP1 LAMA3 KIT MCTP2 PCDH8 PREX2	1.01e-06	184	80	6	32473dbdb2de66391157c5814ef34e790806e4f2
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CA9 HAP1 SPOCK3 LAMA3 KIT PCDH8	1.04e-06	185	80	6	0b5a0df58ae2ad8261f40f152775747af4f3937a
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c13-MKI67-CCL5_l\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GOLGA6L6 LRFN4 CENPE KIF4A MYZAP CIT	1.14e-06	188	80	6	15146fd2c5592ea84d20b1fdd172b39cd60b5bed
ToppCell	PCW_10-12-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CENPE LAMA3 KIF4A ADGRV1 CIT SLC44A3	1.25e-06	191	80	6	39220f4a345e328f7fa4fd462a0abeea821b3e02
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HAP1 SPOCK3 LAMA3 MCTP2 PCDH8 PREX2	1.25e-06	191	80	6	06760c3bb40e4f66879a5f5e09c9abfce4ebbba3
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CENPE LAMA3 KIF4A ADGRV1 CIT SLC44A3	1.29e-06	192	80	6	25378b5e4b0cea8415ff125783511fc25a56fc00
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HAP1 SPOCK3 LAMA3 KIT PCDH8 PREX2	1.29e-06	192	80	6	3abee376c37c3646da33ac381aa63d50a01607a6
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_2-TYR-L2-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HAP1 LAMA3 KIT MCTP2 PCDH8 PREX2	1.64e-06	200	80	6	04954fbe1e2264077228bb582c9a5897a70e6da2
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-PCDH20-L1-2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HAP1 LAMA3 KIT MCTP2 PCDH8 PREX2	1.64e-06	200	80	6	1d67c5d2c617749b521e70879950dea2c9d076d6
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-GGH-L1-3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HAP1 SPOCK3 LAMA3 MCTP2 PCDH8 PREX2	1.64e-06	200	80	6	48303e499251d6754cfa991dc2d96c5563b2123c
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_2-TYR\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HAP1 LAMA3 KIT MCTP2 PCDH8 PREX2	1.64e-06	200	80	6	bfdafb024a7b20d46837b2e6480dd4929253cd62
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-GGH\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HAP1 SPOCK3 LAMA3 MCTP2 PCDH8 PREX2	1.64e-06	200	80	6	4802dd6cae84b41746227a5d1aa1c9b858495e36
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-PCDH20\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HAP1 LAMA3 KIT MCTP2 PCDH8 PREX2	1.64e-06	200	80	6	26c7f2b0afe9e50f2a5c43918ad8e91d7553b72c
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PLPPR4 HAP1 PPFIA2 LAMA3 LYST	1.10e-05	162	80	5	373513f9d0e5007b2e10a8b78d4909dcce9e3b62
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Chat_Htr1f\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	FSTL4 LAMA3 KIT CIT PCDH8	1.43e-05	171	80	5	f9ae7964a3740f559431125c17c660549798cccc
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1_VIP_PCDH20\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HAP1 LAMA3 KIT MCTP2 PCDH8	1.47e-05	172	80	5	35e961c88bfe79046533396912cedf00ca81db7b
ToppCell	facs-Brain_Myeloid-Hippocampus-3m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBXN11 ITGAL TLR8 CCDC136 PREX2	1.51e-05	173	80	5	c63a615998d13b1725b5767f4ad2ec7e2b61db68
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PLPPR4 SPOCK3 SERPINB12 PPFIA2 CCDC136	1.60e-05	175	80	5	8362a46f5804333baa84cd56d450bc147f372a7e
ToppCell	PND03-Epithelial-Epithelial_Airway-Neurosecretory-PNEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PLPPR4 SPOCK3 SERPINB12 PPFIA2 CCDC136	1.60e-05	175	80	5	8b4c62e608f0ec84e563bbf0ebffe3ed44085298
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CA9 HAP1 LAMA3 KIT PCDH8	1.73e-05	178	80	5	2a36475c260088f69f3b8c282d910e5eaa5c5c2d
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HAP1 SPOCK3 KIT PCDH8 PREX2	1.73e-05	178	80	5	3c973aac16988e88f5677d3d695dd772ccfd6570
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HAP1 TRPC4 LAMA3 MCTP2 PCDH8	1.78e-05	179	80	5	cd7f0e8f4abb2a2bac366c8910c8c5fda841dbce
ToppCell	COVID-19-Heart-VSMC\|Heart / Disease (COVID-19 only), tissue and cell type	PPFIA2 CARMIL1 TRPC4 LAMA3 MAP3K5	1.78e-05	179	80	5	a69ad6912b5c10bb9f9d800f724c792341e9bab1
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-6_VIP_RGS16\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HAP1 TRPC4 LAMA3 MCTP2 PCDH8	1.78e-05	179	80	5	5bf191bdc0c32bce83ab5c38f0616e209e420e55
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-2_VIP_PPAPDC1A\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HAP1 LAMA3 KIT PCDH8 PREX2	1.88e-05	181	80	5	42f5a645beeb5a1a746d79ea7fe7fd3786fd35ad
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PLPPR4 PPFIA2 LAMA3 LYST FAM135A	1.93e-05	182	80	5	a8cc56f32efe180e8fb5d69dbe606a794b3db700
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HAP1 SPOCK3 LAMA3 KIT PREX2	1.93e-05	182	80	5	420a8fd30543e37a66ba0786215d056d308660d0
ToppCell	Adult-Immune-natural_killer_cell-D231\|Adult / Lineage, Cell type, age group and donor	ZFYVE28 JAK3 ATM ITGAL MCTP2	1.93e-05	182	80	5	dbf47bf4754d8ec3bc3ab1d5be7a6c47a7afbf43
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-NP-L5_NP_ALM_Trhr_Nefl\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MRO MYZAP TEKT5 TMC3	2.02e-05	89	80	4	eda156a61e7d14087cfdae5e733d6862834fb0e5
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HAP1 SPOCK3 LAMA3 KIT PCDH8	2.09e-05	185	80	5	cefd81adb480c027545a5c78dcd05669783717f4
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HAP1 SPOCK3 KIT PCDH8 PREX2	2.09e-05	185	80	5	bdfa8c284bbc5e85c806327fbb7778cf16242a38
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-4_VIP_CHRNA2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HAP1 LAMA3 KIT MCTP2 PCDH8	2.09e-05	185	80	5	3189e91fe26df59bd605d2b6223ceb1779daf0b8
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HAP1 SPOCK3 LAMA3 KIT PCDH8	2.20e-05	187	80	5	ae2ee6f8e5c37cb88a67f3e742cf86e57657bfaf
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HAP1 LAMA3 KIT MCTP2 PCDH8	2.25e-05	188	80	5	6ee3f8f94ea7bdf652c9575fc65bff08070093a4
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HAP1 SPOCK3 LAMA3 KIT PCDH8	2.43e-05	191	80	5	764c3a8829ae1253a0790744138266e81fc075ec
ToppCell	Adult-Immune-natural_killer_cell\|Adult / Lineage, Cell type, age group and donor	ZFYVE28 JAK3 LRFN2 ITGAL MCTP2	2.43e-05	191	80	5	758ec27e47d7662a5175305e98a1506c6859dbf7
ToppCell	Children_(3_yrs)-Immune-natural_killer_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ZFYVE28 LRFN2 ATM ITGAL MCTP2	2.43e-05	191	80	5	9b8b64a36e27a2523b8730c7922fd7ad865a021e
ToppCell	PCW_13-14-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CENPE LAMA3 KIF4A ADGRV1 CIT	2.62e-05	194	80	5	c197e4acbff42a9f0410b6801c2bfcf6160aefc1
ToppCell	ILEUM-inflamed-(6)_ILC\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	NRIP1 ZNF571 KIT MCTP2 ZNF331	2.62e-05	194	80	5	4d51d49366c34ff1241770b4acc0167a43b3155a
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CARMIL1 LAMA3 ADGRV1 CIT ADCY9	2.62e-05	194	80	5	97534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CENPE KIF4A MYZAP KIT CIT	2.82e-05	197	80	5	a41420d4b6d502c2f594c054c7efbb5d4eac83ff
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CENPE KIF4A MYZAP KIT CIT	2.82e-05	197	80	5	1c89d6836eed30c50c765f7dde9cc8ee15c363d2
ToppCell	Caecum-T_cell-Activated_CD4_T\|T_cell / Region, Cell class and subclass	CXCR5 FAM153B FMN1 ATM ZNF331	2.96e-05	199	80	5	13173cc4dcc8e856680372b0a4ad4f36afa892c1
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-HS3ST3A1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HAP1 LAMA3 MCTP2 PCDH8 PREX2	3.03e-05	200	80	5	dd68ce6934eafb75d918042fcf7fd7a750294b7f
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CBLN1-L2-4\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CA9 HAP1 LAMA3 MCTP2 PCDH8	3.03e-05	200	80	5	2086024ce808b8796ed508a229b098eb02f8828a
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-OPRM1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HAP1 LAMA3 KIT PCDH8 PREX2	3.03e-05	200	80	5	559cf4001a3f985c8357f0102b34fab2e34d2a04
ToppCell	Neuronal-Inhibitory-iA\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HAP1 SPOCK3 LAMA3 KIT PREX2	3.03e-05	200	80	5	5ef4a3dc18a44292184a59ced916183c0699b01e
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-QPCT\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HAP1 TRPC4 LAMA3 MCTP2 PCDH8	3.03e-05	200	80	5	85e1b598c9f3976215b20eeda077d8aab621cce6
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HAP1 LAMA3 KIT PCDH8 PREX2	3.03e-05	200	80	5	913487e065dd580c9cbcbb3c3fc76a8d446f8856
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CBLN1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CA9 HAP1 LAMA3 MCTP2 PCDH8	3.03e-05	200	80	5	35951db6a4f442ac9e13f1b8cc5b4a33481f92c8
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CCDC184-L1-3\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CA9 HAP1 LAMA3 KIT PCDH8	3.03e-05	200	80	5	140aff451cd58e1d544ee668e49e37e577f6f068
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-QPCT-L2-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HAP1 TRPC4 LAMA3 MCTP2 PCDH8	3.03e-05	200	80	5	2f2c5331511a924fa0bb1689f4c81641d754c9b9
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-CCDC184\|Neuronal / cells hierarchy compared to all cells using T-Statistic	CA9 HAP1 LAMA3 KIT PCDH8	3.03e-05	200	80	5	85bfa7f4dd07a4d4a88330e88f5886fd1ecfdeeb
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-OPRM1-L1-4\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HAP1 LAMA3 KIT PCDH8 PREX2	3.03e-05	200	80	5	cc0d639d38eb99414ba8b54d3000701962394465
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_3-HS3ST3A1-L3-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HAP1 LAMA3 MCTP2 PCDH8 PREX2	3.03e-05	200	80	5	06ea96428728199a30a0f836647d6448287d3848
ToppCell	AT2_cells-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	CA9 PLPPR4 ZNF229 CCDC40	9.15e-05	131	80	4	ff4e618bd944f852bbd34438f740187aca82460f
ToppCell	COVID-19_Convalescent-PLT_3\|World / Disease Group and Platelet Clusters	DENND1B POMGNT1 ATM ZNF529	1.09e-04	137	80	4	bb54bb81b450462ad521b57e1a07a80ce1678e67
ToppCell	Fetal_29-31_weeks-Immune-mast_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NRIP1 CENPE KIT MCTP2	1.35e-04	145	80	4	dc89d817a9bef24a07e992efdab4136f12ceb399
ToppCell	10x3'2.3-week_17-19-Hematopoietic-HSC/MPP_and_pro-LMPP\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	ZFYVE28 SPOCK3 ADGRV1 PREX2	1.79e-04	156	80	4	331b63bf4744ab494c3959436a8a0d8a1e4c0de4
ToppCell	368C-Lymphocytic-NK_cells\|368C / Donor, Lineage, Cell class and subclass (all cells)	LRFN1 CENPE KIF4A KIT	1.84e-04	157	80	4	ef5c0ace4cd500b6cc50fb7076298f3d3543b40c
ToppCell	Control-Myeloid-Monocytes,_Macrophages-Mast-cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CA9 ITGAL MCTP2 TFRC	1.93e-04	159	80	4	81782e9e370558d61af5e0c760ac9759d69fb725
ToppCell	10x5'v1-week_17-19-Hematopoietic-HSC/MPP_and_pro-HSC/MPP\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	NRIP1 XIRP2 SPOCK3 PREX2	2.02e-04	161	80	4	aee74a2e7a8acd2950341963f1c04b59c7862183
ToppCell	droplet-Marrow-BM-30m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMN1 GIGYF2 TLR8 KIF1C	2.07e-04	162	80	4	75df7ff779a3b9159ba97d852da1f8df650b9ce5
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-Tuft-related-Tuft\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FMN1 CARMIL1 MYZAP KIT	2.07e-04	162	80	4	80619a93c57fe16daf91dc571874ef9ac888953d
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1_VIP_PCDH20\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LAMA3 KIT MCTP2 PCDH8	2.12e-04	163	80	4	a53294b229fc24d4a574f0c156755b4fa7c757fc
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CENPE KIF4A MYZAP PREX2	2.12e-04	163	80	4	7864e966c228282b4b63c43164dba3faba21026d
ToppCell	droplet-Liver-LIVER-NPC-1m-Lymphocytic-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UBXN11 FMN1 CEP162 COG5	2.22e-04	165	80	4	8c7a6f9e2ca0ce077426d3d0726e3f5a4c03b296
ToppCell	droplet-Spleen-nan-21m-Lymphocytic-NK_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MRO ITGAL KIT CCDC136	2.32e-04	167	80	4	92ddabbe55315856d8ea6f8db1560b6d97636bac
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-mesothelial_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CA9 FAM153B MMEL1 TM9SF1	2.43e-04	169	80	4	0cece9b2bb1f58e465c20ec8735a4fc3c1021f03
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CA9 FAM153B MMEL1 TM9SF1	2.43e-04	169	80	4	6937c46b119d4ce382fc8c2fa5925ede5ae89c81
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-4_VIP_CHRNA2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CXCR5 LAMA3 KIT PCDH8	2.49e-04	170	80	4	45584bd9953257dd28c06ffbbfe4395ce7b1b88d
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HAP1 LAMA3 MCTP2 PCDH8	2.54e-04	171	80	4	a5634b76476b8b2488a706bbab5141f7bd94631f
ToppCell	PND01-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	UBXN11 CENPE ITGAL CIT	2.54e-04	171	80	4	6e7ade1d14a3ec4c566476aac3eb509bd2661e39
ToppCell	10x3'2.3-week_12-13-Myeloid_DC-DC-DC1\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	LRFN1 SPOCK3 MYZAP FAM135A	2.54e-04	171	80	4	04346d4eb726875e3537e215ea081a0318ca4ddd
ToppCell	droplet-Liver-Hepatocytes-21m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRIP1 PLEKHM2 HAP1 ITGAL	2.60e-04	172	80	4	574ebdf36e45222bcd907cd2c2ee7ff50ed4573a
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-6_VIP_RGS16\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HAP1 TRPC4 LAMA3 PCDH8	2.60e-04	172	80	4	8b396d1e9173da104d467e42286379fe07cee257
ToppCell	droplet-Liver-Hepatocytes-21m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRIP1 PLEKHM2 HAP1 ITGAL	2.60e-04	172	80	4	1627fa7035b0e0bbc82a1c0f000d8231254c680a
ToppCell	Children_(3_yrs)-Immune-natural_killer_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ZFYVE28 ACTN3 ITGAL MCTP2	2.72e-04	174	80	4	33d6b81f31bfcb9c4b30206d88e20b9a94fba4a2
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Chat_Htr1f\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LAMA3 KIT CIT PCDH8	2.72e-04	174	80	4	a5f2a4e3b25e6084bd7003a53da86a44f6fcf294
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L3-6_VIP_KCTD13\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HAP1 SPOCK3 LAMA3 PCDH8	2.72e-04	174	80	4	62f5dc7086e1491fc90f005ccadfa1b772b52fad
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HAP1 LAMA3 MCTP2 PCDH8	2.78e-04	175	80	4	e78bf0c33a741bb97e987e41ac33da9e623a08ec
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HAP1 LAMA3 KIT PCDH8	2.78e-04	175	80	4	9d09636a103daa8f622c3dbfd1f1536aaec3b6bb
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRFN4 PLEKHM2 ITGAL STAT1	2.78e-04	175	80	4	f7cd2ef79d91d64976fcdb5f1e7343b24ba27456
ToppCell	droplet-Liver-Hepatocytes-21m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRIG2 PLEKHM2 HAP1 ITGAL	2.84e-04	176	80	4	8e89471f838ea81235256cc2470f1c12c9b75f8a
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND1B ADAM17 ITGAL STAT1	2.84e-04	176	80	4	5e46a09a36b9645b1b1fcb0b64bd0898561af3a9
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HAP1 LAMA3 KIT PCDH8	2.90e-04	177	80	4	85e270b4a0b0da77ffe5987a099e827c02a4adf3
ToppCell	facs-Skin-Anagen-24m-Epithelial-actively_dividing_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CENPE BBS7 KIF4A CIT	2.90e-04	177	80	4	8a0f0fbb06cdacb99a3fdba0da3e0494b891db4f
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_SSTR1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SPOCK3 KIT PCDH8 PREX2	2.90e-04	177	80	4	fdab7b7ddfb06f913b8224c0c80574dc3cf4cbd4
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CA9 HAP1 KIT PCDH8	2.90e-04	177	80	4	84116796ca4c7007508c0f1a68a1135c7b922278
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_ADARB2_ADAM33\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SPOCK3 KIT PCDH8 PREX2	2.90e-04	177	80	4	1cb78133ac09ea3a3f5b5de07151033998406512
ToppCell	facs-Skin-Anagen-24m-Epithelial-keratinocyte_stem_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CENPE BBS7 KIF4A CIT	2.90e-04	177	80	4	e9d7682517fb30fd2ad535d59779d718a7024c13
ToppCell	droplet-Liver-LIVER_HEP-30m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND1B ADAM17 ITGAL STAT1	2.90e-04	177	80	4	14fb8d182775dfd0e49aa7e4e12543a85b3b8bd6
ToppCell	E16.5-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ZFYVE28 SPOCK3 SERPINB12 PPFIA2	2.96e-04	178	80	4	d3a75a8082e70543b84c35d53fe77625300d19fa
Drug	17-DMAG; Down 200; 0.1uM; MCF7; HT_HG-U133A	NRIP1 LRFN4 LAMA3 DCUN1D4 LYST ADCY9 TFRC	4.96e-06	191	80	7	5210_DN
Drug	6-fluorocholesterol	ATM LYST	1.22e-05	2	80	2	CID000135206
Drug	25-fluorocholesterol	ATM LYST	1.22e-05	2	80	2	CID006454807
Disease	Chronic myeloproliferative disorder	JAK3 CENPE KIT	1.48e-05	19	75	3	C1292778
Disease	obsessive-compulsive disorder, anorexia nervosa	CARMIL1 KIT	3.81e-05	4	75	2	EFO_0004242, MONDO_0005351
Disease	Acute myelomonocytic leukemia	KMT2A KIT	6.34e-05	5	75	2	C0023479
Disease	Bare Lymphocyte Syndrome	JAK3 TFRC	9.50e-05	6	75	2	C0242583
Disease	monocyte count	ZFYVE28 NRIP1 UBXN11 CARMIL1 ATM ADGRV1 KIT LYST TLR8 PREX2 ADCY9 MAP3K5	1.17e-04	1320	75	12	EFO_0005091
Disease	disease of cellular proliferation (implicated_via_orthology)	JAK3 ATM	1.33e-04	7	75	2	DOID:14566 (implicated_via_orthology)
Disease	Secondary Biliary Cholangitis	CXCR5 MMEL1 DENND1B	1.69e-04	42	75	3	C0238065
Disease	Biliary cirrhosis	CXCR5 MMEL1 DENND1B	1.69e-04	42	75	3	C0023892
Disease	Biliary Cirrhosis, Primary, 1	CXCR5 MMEL1 DENND1B	1.69e-04	42	75	3	C4551595
Disease	Primary biliary cirrhosis	CXCR5 MMEL1 DENND1B	2.36e-04	47	75	3	C0008312
Disease	Omenn Syndrome	JAK3 TFRC	1.06e-03	19	75	2	C2700553
Disease	Severe Combined Immunodeficiency	JAK3 TFRC	1.18e-03	20	75	2	C0085110
Disease	ovarian carcinoma	HAP1 SPOCK3 FRMPD2 LAMA3 ADGRV1	1.37e-03	321	75	5	EFO_0001075
Disease	Huntington's disease (is_implicated_in)	HAP1 MAP3K5	1.56e-03	23	75	2	DOID:12858 (is_implicated_in)
Disease	nevus count, cutaneous melanoma	FMN1 ATM ADGRV1	1.63e-03	91	75	3	EFO_0000389, EFO_0004632
Disease	breast carcinoma (is_implicated_in)	STAT1 TFRC	1.84e-03	25	75	2	DOID:3459 (is_implicated_in)
Disease	Liver carcinoma	MRO CENPE KMT2A KIF4A ATM STAT1	1.85e-03	507	75	6	C2239176
Disease	upper face morphology measurement	TRPC4 FSTL4 ADGRV1	1.96e-03	97	75	3	EFO_0010949
Disease	lung small cell carcinoma (is_implicated_in)	LAMA3 ATM	2.31e-03	28	75	2	DOID:5409 (is_implicated_in)
Disease	longitudinal BMI measurement, response to amisulpride	FSTL4 ADCY9	2.48e-03	29	75	2	EFO_0005937, EFO_0010718

Protein segments in the cluster

Peptide	Gene	Start	Entry
LRNTLDYLRSFLNDS	DCUN1D4	176	Q92564
LEFSRTINLDLSNYD	DCUN1D4	256	Q92564
LLEILDSYDQNALIS	BBS7	696	Q8IWZ6
QSDLSLDRQLTGLYD	COG7	241	P83436
LDRLDNYNDTSLVEN	CXCR5	21	P32302
QDYLIIASQRDDSEL	ADGRV1	3371	Q8WXG9
DSLYNIRLLREFSNE	CAMSAP1	281	Q5T5Y3
DLLSLLNRYEDQLDE	CIT	181	O14578
NSAYEQLLSRLEEIA	CA9	286	Q16790
DLETLAALYENRAQE	FMN1	1086	Q68DA7
DLNSLISSDYELLSD	JAK3	776	P52333
ALRDQALRDLNTYTE	ZFYVE28	141	Q9HCC9
TDLLYLDLSENRLES	FLII	151	Q13045
YSIDNNELLDFLSRV	MCTP2	836	Q6DN12
DSLNEYEAKLSDLRA	LAMA3	2026	Q16787
ELALDLEDLLSFSYQ	KIT	761	P10721
EILSARLTQALDNYE	HERC3	1031	Q15034
LSTVEDLDLSYNNLE	LRFN1	161	Q9P244
DNDSYTLDQLLRQER	ASB12	36	Q8WXK4
DYSADDLNALQLISS	FAM135A	121	Q9P2D6
QELDRESQAAYSLEL	PCDH8	201	O95206
RLEDLASLVYLNESS	MYO18A	406	Q92614
INLLADNRYLTAEET	NCOA5	346	Q9HCD5
ADLLLEQQRLYADSD	KIF1C	661	O43896
RLLRQNQDSYLADDS	NRIP1	821	P48552
DALSLELYRNTITDE	GOLGA6L6	191	A8MZA4
QTRTLLDDENDSLRY	MRO	136	Q9BYG7
LDDENDSLRYSAFVL	MRO	141	Q9BYG7
RLDEEYSNLNFSEDL	MMEL1	521	Q495T6
RLLQYENVDEDSSDS	INO80E	56	Q8NBZ0
SLNELDYLSQGIDLS	COG5	206	Q9UP83
ESLYNALQSLRDREF	ATM	2126	Q13315
YLQDSALDDERLASK	GIGYF2	501	Q6Y7W6
AEQLLEDLRNDSSDY	FRMPD2	41	Q68DX3
LLRFDDYNSDSSLTL	FSTL4	221	Q6MZW2
VNLRDELLQLYSDSD	HAP1	246	P54257
YRLTLQDTEDALSQD	CCDC40	586	Q4G0X9
SLNFLDQELERSYRT	ADCY9	751	O60503
IDYSRLNKELDSNDS	CEP162	146	Q5TB80
ETLDLNDLLIYRNLS	LYST	3176	Q99698
ADSNLEETLNTLRYA	KIF4A	316	O95239
LDTYNTELLKSDSDN	KMT2A	2821	Q03164
YTNDLSIELDTEREN	SLC44A3	266	Q8N4M1
YLTQDTRELNLQDFS	CARMIL1	186	Q5VZK9
ELENDLNETLRSLYN	DENND1B	121	Q6P3S1
EEDQSLLLSQFREYL	NOC4L	161	Q9BVI4
IESELNSLRADYDNL	CENPE	496	Q02224
ELLIRDVLQELSSYN	FAM153B	221	P0C7A2
LDENFDYSSLALLLQ	PPFIA2	1141	O75334
LNENSLESYLRLFQE	PLEKHM2	101	Q8IWE5
NLLLSYRDIQDYDSI	MAP3K5	316	Q99683
ATQLSEELAQLRDAY	SYNC	281	Q9H7C4
YLYQESLLLSNLDDS	TMC3	21	Q7Z5M5
LSQLDDQYSRFSLEN	STAT1	61	P42224
LSQSIHLLEEDDSLY	POMGNT1	406	Q8WZA1
SYELDRLLTENQNLE	TEKT5	156	Q96M29
LSVELSLSNLEEDAY	ITGAL	801	P20701
ELNLDYERYNSQLLS	TFRC	606	P02786
RFTLEDSYDLNSILQ	SERPINB12	301	Q96P63
SEEDLLLQDFSRNLS	SSR3	11	Q9UNL2
LSQRDYDSALLQEVR	ACTN3	431	Q08043
DSLLSDYDILSLSNI	ADAM17	36	P78536
LNEEYRALQESNSSL	CCDC136	236	Q96JN2
DSSQKDLNSEREYLE	XIRP2	376	A4UGR9
SLRQTYELNDLNRDS	PLPPR4	656	Q7Z2D5
TELSDLEVLDLSYNS	TLR8	551	Q9NR97
LENYSNLVSLDLESA	ZNF331	36	Q9NQX6
RLLLALLEYSDSETQ	PREX2	1246	Q70Z35
YSSELNVNALELDDS	TRBV5-4	91	A0A0C4DH59
AQALLRDYALNTDSA	RALGAPB	741	Q86X10
DTNYDLLLDQSELRS	SPOCK3	261	Q9BQ16
EELELLDSTQRQLYQ	ZNF229	46	Q9UJW7
NYSNLLSLDLESRNE	ZNF529	71	Q6P280
LENYSNLISLDLESS	ZNF571	36	Q7Z3V5
SSRELEIILNYRDDN	TRPC4	261	Q9UBN4
LRNDLARYNLDEETT	TM9SF1	261	O15321
DSYSSQLEDRIAENL	TMC7	71	Q7Z402
DFDRLLASLQDLSEL	UBXN11	196	Q5T124
DFLLTLEDLDLSYNN	LRFN2	146	Q9ULH4
SLEDLDLSYNNLRQV	LRFN4	146	Q6PJG9
LDLSYNQLTRLDESA	LRIG2	316	O94898
ENNELQSRLDYLTET	MYZAP	401	P0CAP1